CN108478661A - 一种淡化黄褐斑胶囊及其制备方法 - Google Patents
一种淡化黄褐斑胶囊及其制备方法 Download PDFInfo
- Publication number
- CN108478661A CN108478661A CN201810128130.1A CN201810128130A CN108478661A CN 108478661 A CN108478661 A CN 108478661A CN 201810128130 A CN201810128130 A CN 201810128130A CN 108478661 A CN108478661 A CN 108478661A
- Authority
- CN
- China
- Prior art keywords
- capsule
- parts
- weight
- supplementary material
- chloasma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 64
- 208000003351 Melanosis Diseases 0.000 title claims abstract description 53
- 206010008570 Chloasma Diseases 0.000 title claims abstract description 52
- 238000010612 desalination reaction Methods 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 30
- 108010010803 Gelatin Proteins 0.000 claims abstract description 15
- 241000830535 Ligustrum lucidum Species 0.000 claims abstract description 15
- 244000241872 Lycium chinense Species 0.000 claims abstract description 15
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 15
- 239000008273 gelatin Substances 0.000 claims abstract description 15
- 229920000159 gelatin Polymers 0.000 claims abstract description 15
- 235000019322 gelatine Nutrition 0.000 claims abstract description 15
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 15
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 15
- 210000000582 semen Anatomy 0.000 claims abstract description 15
- 244000286838 Eclipta prostrata Species 0.000 claims abstract description 11
- 239000000843 powder Substances 0.000 claims description 84
- 239000012141 concentrate Substances 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 14
- 238000005469 granulation Methods 0.000 claims description 14
- 230000003179 granulation Effects 0.000 claims description 14
- 238000012856 packing Methods 0.000 claims description 14
- 239000006228 supernatant Substances 0.000 claims description 14
- 235000020985 whole grains Nutrition 0.000 claims description 14
- 230000003139 buffering effect Effects 0.000 claims description 7
- 238000005119 centrifugation Methods 0.000 claims description 7
- 235000019441 ethanol Nutrition 0.000 claims description 7
- 239000000945 filler Substances 0.000 claims description 7
- 239000007902 hard capsule Substances 0.000 claims description 7
- 238000007689 inspection Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 239000011812 mixed powder Substances 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 239000000047 product Substances 0.000 claims description 7
- 238000012216 screening Methods 0.000 claims description 7
- 238000007873 sieving Methods 0.000 claims description 7
- 239000011122 softwood Substances 0.000 claims description 7
- 239000007921 spray Substances 0.000 claims description 7
- 238000003860 storage Methods 0.000 claims description 7
- 240000001341 Reynoutria japonica Species 0.000 abstract description 14
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 9
- 239000003814 drug Substances 0.000 abstract description 7
- 230000036541 health Effects 0.000 abstract description 5
- 238000004140 cleaning Methods 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 4
- 230000000368 destabilizing effect Effects 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 230000035764 nutrition Effects 0.000 abstract description 3
- 238000012545 processing Methods 0.000 abstract description 3
- 230000004224 protection Effects 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract 1
- 229940116269 uric acid Drugs 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 description 6
- 244000025254 Cannabis sativa Species 0.000 description 5
- 206010013786 Dry skin Diseases 0.000 description 5
- 240000002853 Nelumbo nucifera Species 0.000 description 5
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 5
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 5
- 230000008859 change Effects 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 238000012449 Kunming mouse Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 208000005374 Poisoning Diseases 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 240000006365 Vitis vinifera Species 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 241001116389 Aloe Species 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 240000001008 Dimocarpus longan Species 0.000 description 1
- 235000002722 Dioscorea batatas Nutrition 0.000 description 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 description 1
- 240000001811 Dioscorea oppositifolia Species 0.000 description 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 description 1
- 235000000235 Euphoria longan Nutrition 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 241000863032 Trieres Species 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000003359 percent control normalization Methods 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种淡化黄褐斑胶囊的配方,涉及医药保健食品技术领域,含以下组份:一种淡化黄褐斑胶囊的配方,按重量份计包括以下组份:当归8‑15重量份、白芍8‑15重量份、旱莲草8‑15重量份、熟地10‑30重量份、菟丝子10‑30重量份、女贞子10‑1重量5份、何首乌10‑15重量份、枸杞子6‑10重量份以及阿胶6‑10重量份。另外,本发明还公开了该淡化黄褐斑胶囊的制备方法。本发明的原辅料具有协同增进作用,有显著降低尿酸的作用,长期服用本发明的淡化黄褐斑胶囊,并且全程同线处理,避免了不稳定因素造成的营养流失;整个制备工艺在一定的洁净区内完成,保证了工作环境的洁净,最大程度的降低环境对胶囊的影响。
Description
技术领域
本发明涉及医药保健食品技术领域,具体涉及一种淡化黄褐斑胶囊及其制备方法。
背景技术
黄褐斑也称肝斑,为面部的黄褐色色素沉着。多对称蝶形分布于颊部。多见于女性,血中雌激素水平高是主要原因,其发病与妊娠、长期口服避孕药、月经紊乱有关。女性脸上黄褐斑会影响其美丽,及早淡化治疗是非常不要的。
中国专利申请号201611182681.3公开了一种淡化黄褐斑美容养颜女性保健酒,包括以下重量份原料:山药多糖5-40份、白芷挥发油10-50份、龙眼肉多肽10-30份、桃仁苦杏仁甙10-35份,余量为葡萄酒,总共1000份。该发明的保健酒,以低度数的葡萄酒为基酒,适合女性饮用,其配方根据我国食疗学、中医学等医药保健理论为指导,通过活血祛瘀、补肝益气、健脾益肾等作用相互协调,达到淡化黄褐斑的目的。但是女性很多不喜饮酒,恐达不到与其效果。
中国专利申请号201510533203.1公开了一种治疗黄褐斑的植物复方凝胶剂及其制备方法,包括天然植物组分,所述天然植物组分及重量份数为:丹参15-25份、墨旱莲15-25份、茯苓15-25份、芦荟15-25份、黄苓10-25份。该发明提供的一种治疗黄褐斑的植物复方凝胶剂,具有天然植物活性成分,按提供的配方和制备方法制成的凝胶剂,和任何普通的治疗治疗黄褐斑的药物都可配合使用,适用于任何皮肤,而且无过敏反应,无毒副作用,使药物能迅速渗入皮肤,达到治疗黄褐斑的目的,疗效确切、不易复发,集天然植物活性精华,能迅速淡化黄褐斑,改善皮色,恢复肌肤功效。但是制作工艺较复杂,恐不能工业化规模生产。
发明内容
本发明的目的在于提供一种淡化黄褐斑胶囊的制备方法,以解决现有技术中导致的上述缺陷。
本发明通过以下技术方案来实现,一种淡化黄褐斑胶囊的配方,按重量份计,包括:
优选的,一种淡化黄褐斑胶囊的配方,按重份计,包括:
一种淡化黄褐斑胶囊的制备方法,包括步骤如下:
(1)取经检验合格的当归、白芍、旱莲草、熟地、菟丝子、女贞子、何首乌、枸杞子以及阿胶将原辅料除去外包装,内包装通过缓冲间进入洁净区;
(2)浸膏粉的制备:按配方将原辅料制成浸膏粉;
(3)干燥、过筛:将浸膏粉干燥过筛备用;
(4)制粒、整粒:将浸膏粉加入75%乙醇制软材,20目筛制粒,58-62℃干燥,16目筛整粒;
(5)灌装胶囊:将总混合粉用全自动硬胶囊充填机灌装胶囊,得胶囊,1.2g-1.8g/粒;
(6)抛光、挑选:除去胶囊表面的粉末;除去不合格的产品;
(7)包装、质检、入库。
优选的,所述步骤(1)中所述洁净区温湿度分别为45℃-48℃,45%。
优选的,所述步骤(2)中的浸膏粉制备步骤如下:
(1)清洗干燥:按配方将原辅料按配方称取洗净干燥;
(2)粉碎过筛:将步骤(1)中原辅料粉碎过300-500目筛得原辅料粉末;
(3)煎煮:将原辅料粉末分三次加水煎煮,第一次煎煮所加水与原辅料粉末质量比为12:1,时间为3-6小时,第二次煎煮加水与原辅料粉末质量比为10:1,时间为2-3小时,第三次煎煮加水与原辅料粉末质量比为8:1,时间为1-2小时;
(4)过滤:将煎煮液用离心机离心45分钟,离心速率为2500r/min,取上清液备用;
(5)浓缩:将上清液在55-65℃下减压浓缩,得一定浓度的浓缩液;
(6)喷雾干燥:将浓缩液喷雾干燥成浸膏粉。
优选的,所述浓缩液的浓度为0.10-0.15倍的浓缩液。
采用以上技术方案,与现有技术相比,本发明具有以下优点:
当归、白芍、旱莲草、熟地、菟丝子、女贞子、何首乌、枸杞子以及阿胶具有协同增进作用,有显著淡化黄褐斑的作用,长期服用本发明的淡化黄褐斑胶囊,并且全程同线处理,避免了不稳定因素造成的营养流失;整个制备工艺在一定的洁净区内完成,保证了工作环境的洁净,最大程度的降低环境对胶囊的影响。
具体实施方式
为使本发明的技术手段、创作特征、达成目的与功效易于明白了解,下面结合具体实施方式,进一步阐述本发明。
实施例1
一种淡化黄褐斑胶囊的配方,按重量份计包括以下组份:当归10份、白芍10份、旱莲草10份、熟地15份、菟丝子15份、女贞子12份、何首乌12份、枸杞子9份以及阿胶9份。
一种淡化黄褐斑胶囊的制备方法,包括步骤如下:
(1)取经检验合格的当归、白芍、旱莲草、熟地、菟丝子、女贞子、何首乌、枸杞子以及阿胶将原辅料除去外包装,内包装通过缓冲间进入洁净区;
(2)浸膏粉的制备:按配方将原辅料制成浸膏粉;
(3)干燥、过筛:将浸膏粉干燥过筛备用;
(4)制粒、整粒:将浸膏粉加入75%乙醇制软材,20目筛制粒,58℃干燥,16目筛整粒;
(5)灌装胶囊:将总混合粉用全自动硬胶囊充填机灌装胶囊,得胶囊,1.2g/粒;
(6)抛光、挑选:除去胶囊表面的粉末;除去不合格的产品;
(7)包装、质检、入库。
所述步骤(1)中所述洁净区温湿度分别为45℃,45%。所述步骤(2)中的浸膏粉制备步骤如下:
(1)清洗干燥:按配方将原辅料按配方称取洗净干燥;
(2)粉碎过筛:将步骤(1)中原辅料粉碎过300目筛得原辅料粉末;
(3)煎煮:将原辅料粉末分三次加水煎煮,第一次煎煮所加水与原辅料粉末质量比为12:1,时间为3小时,第二次煎煮加水与原辅料粉末质量比为10:1,时间为2小时,第三次煎煮加水与原辅料粉末质量比为8:1,时间为1小时;
(4)过滤:将煎煮液用离心机离心45分钟,离心速率为2500r/min,取上清液备用;
(5)浓缩:将上清液在55℃下减压浓缩,得一定浓度的浓缩液;
(6)喷雾干燥:将浓缩液喷雾干燥成浸膏粉。
所述浓缩液的浓度为0.10倍的浓缩液。
实施例2
一种淡化黄褐斑胶囊的配方,按重量份计包括以下组份:当归8份、白芍8份、旱莲草8份、熟地20份、菟丝子20份、女贞子10份、何首乌10份、枸杞子8份以及阿胶8份。
一种淡化黄褐斑胶囊的制备方法,包括步骤如下:
(1)取经检验合格的当归、白芍、旱莲草、熟地、菟丝子、女贞子、何首乌、枸杞子以及阿胶将原辅料除去外包装,内包装通过缓冲间进入洁净区;
(2)浸膏粉的制备:按配方将原辅料制成浸膏粉;
(3)干燥、过筛:将浸膏粉干燥过筛备用;
(4)制粒、整粒:将浸膏粉加入75%乙醇制软材,20目筛制粒,59℃干燥,16目筛整粒;
(5)灌装胶囊:将总混合粉用全自动硬胶囊充填机灌装胶囊,得胶囊,1.4g/粒;
(6)抛光、挑选:除去胶囊表面的粉末;除去不合格的产品;
(7)包装、质检、入库。
所述步骤(1)中所述洁净区温湿度分别为46℃,45%。所述步骤(2)中的浸膏粉制备步骤如下:
(1)清洗干燥:按配方将原辅料按配方称取洗净干燥;
(2)粉碎过筛:将步骤(1)中原辅料粉碎过400目筛得原辅料粉末;
(3)煎煮:将原辅料粉末分三次加水煎煮,第一次煎煮所加水与原辅料粉末质量比为12:1,时间为4小时,第二次煎煮加水与原辅料粉末质量比为10:1,时间为3小时,第三次煎煮加水与原辅料粉末质量比为8:1,时间为2小时;
(4)过滤:将煎煮液用离心机离心45分钟,离心速率为2500r/min,取上清液备用;
(5)浓缩:将上清液在62℃下减压浓缩,得一定浓度的浓缩液;
(6)喷雾干燥:将浓缩液喷雾干燥成浸膏粉。
所述浓缩液的浓度为0.14倍的浓缩液。
实施例3
一种淡化黄褐斑胶囊的配方,按重量份计包括以下组份:当归9份、白芍9份、旱莲草9份、熟地22份、菟丝子22份、女贞子12份、何首乌12份、枸杞子7份以及阿胶7份。
一种淡化黄褐斑胶囊的制备方法,包括步骤如下:
(1)取经检验合格的当归、白芍、旱莲草、熟地、菟丝子、女贞子、何首乌、枸杞子以及阿胶将原辅料除去外包装,内包装通过缓冲间进入洁净区;
(2)浸膏粉的制备:按配方将原辅料制成浸膏粉;
(3)干燥、过筛:将浸膏粉干燥过筛备用;
(4)制粒、整粒:将浸膏粉加入75%乙醇制软材,20目筛制粒,61℃干燥,16目筛整粒;
(5)灌装胶囊:将总混合粉用全自动硬胶囊充填机灌装胶囊,得胶囊,1.6g/粒;
(6)抛光、挑选:除去胶囊表面的粉末;除去不合格的产品;
(7)包装、质检、入库。
所述步骤(1)中所述洁净区温湿度分别为46℃,45%。所述步骤(2)中的浸膏粉制备步骤如下:
(1)清洗干燥:按配方将原辅料按配方称取洗净干燥;
(2)粉碎过筛:将步骤(1)中原辅料粉碎过300目筛得原辅料粉末;
(3)煎煮:将原辅料粉末分三次加水煎煮,第一次煎煮所加水与原辅料粉末质量比为12:1,时间为4小时,第二次煎煮加水与原辅料粉末质量比为10:1,时间为2小时,第三次煎煮加水与原辅料粉末质量比为8:1,时间为1小时;
(4)过滤:将煎煮液用离心机离心45分钟,离心速率为2500r/min,取上清液备用;
(5)浓缩:将上清液在58℃下减压浓缩,得一定浓度的浓缩液;
(6)喷雾干燥:将浓缩液喷雾干燥成浸膏粉。
所述浓缩液的浓度为0.13倍的浓缩液。
实施例4
一种淡化黄褐斑胶囊的配方,按重量份计包括以下组份:当归11份、白芍11份、旱莲草11份、熟地22份、菟丝子22份、女贞子14份、何首乌14份、枸杞子7份以及阿胶7份。
一种淡化黄褐斑胶囊的制备方法,包括步骤如下:
(1)取经检验合格的当归、白芍、旱莲草、熟地、菟丝子、女贞子、何首乌、枸杞子以及阿胶将原辅料除去外包装,内包装通过缓冲间进入洁净区;
(2)浸膏粉的制备:按配方将原辅料制成浸膏粉;
(3)干燥、过筛:将浸膏粉干燥过筛备用;
(4)制粒、整粒:将浸膏粉加入75%乙醇制软材,20目筛制粒,60℃干燥,16目筛整粒;
(5)灌装胶囊:将总混合粉用全自动硬胶囊充填机灌装胶囊,得胶囊,1.5g/粒;
(6)抛光、挑选:除去胶囊表面的粉末;除去不合格的产品;
(7)包装、质检、入库。
所述步骤(1)中所述洁净区温湿度分别为46℃,45%。所述步骤(2)中的浸膏粉制备步骤如下:
(1)清洗干燥:按配方将原辅料按配方称取洗净干燥;
(2)粉碎过筛:将步骤(1)中原辅料粉碎过300-500目筛得原辅料粉末;
(3)煎煮:将原辅料粉末分三次加水煎煮,第一次煎煮所加水与原辅料粉末质量比为12:1,时间为4小时,第二次煎煮加水与原辅料粉末质量比为10:1,时间为3小时,第三次煎煮加水与原辅料粉末质量比为8:1,时间为1小时;
(4)过滤:将煎煮液用离心机离心45分钟,离心速率为2500r/min,取上清液备用;
(5)浓缩:将上清液在65℃下减压浓缩,得一定浓度的浓缩液;
(6)喷雾干燥:将浓缩液喷雾干燥成浸膏粉。
所述浓缩液的浓度为0.12倍的浓缩液。
实施例5
一种淡化黄褐斑胶囊的配方,按重量份计包括以下组份:当归13份、白芍13份、旱莲草13份、熟地25份、菟丝子25份、女贞子14份、何首乌14份、枸杞子8份以及阿胶8份。
一种淡化黄褐斑胶囊的制备方法,包括步骤如下:
(1)取经检验合格的当归、白芍、旱莲草、熟地、菟丝子、女贞子、何首乌、枸杞子以及阿胶将原辅料除去外包装,内包装通过缓冲间进入洁净区;
(2)浸膏粉的制备:按配方将原辅料制成浸膏粉;
(3)干燥、过筛:将浸膏粉干燥过筛备用;
(4)制粒、整粒:将浸膏粉加入75%乙醇制软材,20目筛制粒,61℃干燥,16目筛整粒;
(5)灌装胶囊:将总混合粉用全自动硬胶囊充填机灌装胶囊,得胶囊,1.2g-1.8g/粒;
(6)抛光、挑选:除去胶囊表面的粉末;除去不合格的产品;
(7)包装、质检、入库。
所述步骤(1)中所述洁净区温湿度分别为46℃,45%。所述步骤(2)中的浸膏粉制备步骤如下:
(1)清洗干燥:按配方将原辅料按配方称取洗净干燥;
(2)粉碎过筛:将步骤(1)中原辅料粉碎过400目筛得原辅料粉末;
(3)煎煮:将原辅料粉末分三次加水煎煮,第一次煎煮所加水与原辅料粉末质量比为12:1,时间为5小时,第二次煎煮加水与原辅料粉末质量比为10:1,时间为2小时,第三次煎煮加水与原辅料粉末质量比为8:1,时间为1小时;
(4)过滤:将煎煮液用离心机离心45分钟,离心速率为2500r/min,取上清液备用;
(5)浓缩:将上清液在63℃下减压浓缩,得一定浓度的浓缩液;
(6)喷雾干燥:将浓缩液喷雾干燥成浸膏粉。
所述浓缩液的浓度为0.14倍的浓缩液。
小鼠急性毒性试验:
采用最大耐受剂量法,选用体重为18-22g的昆明种小鼠20只,雌雄各半。取本发明淡化黄褐斑胶囊内容物50g加1%的羧甲基纤维素钠至100mL。给小鼠一日内间隔4小时经口灌胃2次,每次灌胃体积为0.2mL/10g.bw,累积剂量为20.00g/kg.bw。首次灌胃前禁食16小时,灌胃后连续观察两周,记录中毒表现及死亡情况。实验结果如下:
性别 | 动物数(只) | 途径 | 剂量(g/kg.bw) | 死亡数(只) | MTD(g/kg.bw) |
雌 | 10 | 经口 | 20 | 0 | >20.00 |
雄 | 10 | 经口 | 20 | 0 | >20.00 |
以20.00g/kg.bw剂量的本发明样品的淡化黄褐斑胶囊内容物给两种性别的昆明种小鼠灌胃后未见明显中毒症状,观察14天无死亡。观察期末将受试动物处死进行解剖检查,肝、脾、肾、胃、肠、心、肺等主要脏器,未见明显异常改变。说明本发明淡化黄褐斑胶囊对昆明种小鼠雌雄小鼠最大耐受量大于20.00g/kg.bw,属于无毒级。
效果实验:
随机选取60名26-45岁长有黄褐斑的女性志愿者,分为六组,每组十人。受试者身体状况良好,不吸烟,无长期服药病史,受试者使用相同的温和清洁剂清洗脸部后,在两组试用者脸部左右选定相同部位作为试验区,分别食用实施例1-5的胶囊,每天每人2粒,另外一组空白对照组。
祛斑效果判断:
(1)痊愈:黄褐斑颜色全部明显变浅,且不产生新黄褐斑;
(2)显效:黄褐斑颜色明显变浅,面积减少>1/3,不产生新黄褐斑;
(3)有效:黄褐斑颜色变浅,面积减少≤1/3,不产生新黄褐斑;
(4)无效:黄褐斑颜色及面积无明显变化。
组别 | 痊愈/例 | 显效/例 | 有效/例 | 无效/例 | 治愈率 | 有效率 |
实施例1 | 9 | 1 | 0 | 0 | 90% | 100% |
实施例2 | 9 | 1 | 0 | 0 | 90% | 100% |
实施例3 | 10 | 0 | 0 | 0 | 100% | 100% |
实施例4 | 8 | 2 | 0 | 0 | 80% | 100% |
实施例5 | 9 | 1 | 0 | 0 | 90% | 100% |
对照组 | 0 | 0 | 0 | 10 | 0 | 0 |
综上所述,当归、白芍、旱莲草、熟地、菟丝子、女贞子、何首乌、枸杞子以及阿胶具有协同增进作用,有显著淡化黄褐斑的作用,长期服用本发明的淡化黄褐斑胶囊,并且全程同线处理,避免了不稳定因素造成的营养流失;整个制备工艺在一定的洁净区内完成,保证了工作环境的洁净,最大程度的降低环境对胶囊的影响。
由技术常识可知,本发明可以通过其它的不脱离其精神实质或必要特征的实施方案来实现。因此,上述公开的实施方案,就各方面而言,都只是举例说明,并不是仅有的。所有在本发明范围内或在等同于本发明的范围内的改变均被本发明包含。
Claims (6)
1.一种淡化黄褐斑胶囊的配方,其特征在于,按重量份计,包括:
。
2.根据权利要求1所述的一种淡化黄褐斑胶囊的配方,其特征在于,按重份计,包括:
。
3.根据权利要求1-2中任一一项所述的淡化黄褐斑胶囊的制备方法,其特征在于,包括步骤如下:
(1)取经检验合格的取经检验合格的当归、白芍、旱莲草、熟地、菟丝子、女贞子、何首乌、枸杞子以及阿胶将原辅料除去外包装,内包装通过缓冲间进入洁净区;
(2)浸膏粉的制备:按配方将原辅料制成浸膏粉;
(3)干燥、过筛:将浸膏粉干燥过筛备用;
(4)制粒、整粒:将浸膏粉加入75%乙醇制软材,20目筛制粒,58-62℃干燥,16目筛整粒;
(5)灌装胶囊:将总混合粉用全自动硬胶囊充填机灌装胶囊,得胶囊,1.2g-1.8g/粒;
(6)抛光、挑选:除去胶囊表面的粉末;除去不合格的产品;
(7)包装、质检、入库。
4.根据权利要求3所述的一种淡化黄褐斑胶囊的制备方法,其特征在于:所述步骤(1)中所述洁净区温湿度分别为45℃-48℃,45%。
5.根据权利要求3所述的一种淡化黄褐斑胶囊的制备方法,其特征在于:所述步骤(2)中的浸膏粉制备步骤如下:
(1)清洗干燥:按配方将原辅料按配方称取洗净干燥;
(2)粉碎过筛:将步骤(1)中原辅料粉碎过300-500目筛得原辅料粉末;
(3)煎煮:将原辅料粉末分三次加水煎煮,第一次煎煮所加水与原辅料粉末质量比为12:1,时间为3-6小时,第二次煎煮加水与原辅料粉末质量比为10:1,时间为2-3小时,第三次煎煮加水与原辅料粉末质量比为8:1,时间为1-2小时;
(4)过滤:将煎煮液用离心机离心45分钟,离心速率为2500r/min,取上清液备用;
(5)浓缩:将上清液在55-65℃下减压浓缩,得一定浓度的浓缩液;
(6)喷雾干燥:将浓缩液喷雾干燥成浸膏粉。
6.根据权利要求5所述的一种淡化黄褐斑胶囊的制备方法,其特征在于:所述浓缩液的浓度为0.10-0.15倍的浓缩液。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810128130.1A CN108478661A (zh) | 2018-02-08 | 2018-02-08 | 一种淡化黄褐斑胶囊及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810128130.1A CN108478661A (zh) | 2018-02-08 | 2018-02-08 | 一种淡化黄褐斑胶囊及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108478661A true CN108478661A (zh) | 2018-09-04 |
Family
ID=63339914
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810128130.1A Withdrawn CN108478661A (zh) | 2018-02-08 | 2018-02-08 | 一种淡化黄褐斑胶囊及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108478661A (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110711229A (zh) * | 2019-11-29 | 2020-01-21 | 川北医学院附属医院 | 一种消斑药方 |
CN113876920A (zh) * | 2021-10-28 | 2022-01-04 | 吕炜亮 | 一种美容祛斑组合物及其制备方法 |
-
2018
- 2018-02-08 CN CN201810128130.1A patent/CN108478661A/zh not_active Withdrawn
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110711229A (zh) * | 2019-11-29 | 2020-01-21 | 川北医学院附属医院 | 一种消斑药方 |
CN113876920A (zh) * | 2021-10-28 | 2022-01-04 | 吕炜亮 | 一种美容祛斑组合物及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103627611B (zh) | Sod美白去斑养生保健酒及其制备方法 | |
CN100998767A (zh) | 一种治疗骨折的中药及其制备方法 | |
CN108478661A (zh) | 一种淡化黄褐斑胶囊及其制备方法 | |
CN100528214C (zh) | 治疗癫痫病的胶囊及制备方法 | |
CN108066384A (zh) | 一种具有增强免疫力功能的中药制剂及其制备方法 | |
CN101036721A (zh) | 鹿胎软胶囊及其制造方法 | |
CN102793848A (zh) | 一种治疗夜盲的中药散剂 | |
CN112494569B (zh) | 一种提高免疫力的中药组合物及其制备方法和用途 | |
CN112316051B (zh) | 养血化痰中药组合物及其中药制剂、制备方法和应用 | |
CN104888137B (zh) | 一种治疗多囊卵巢综合症的药物制剂 | |
CN104306934B (zh) | 一种具有增强免疫力的药物组合物及其制备方法 | |
CN107184739A (zh) | 预防、治疗鸡感冒的药物及其制备方法 | |
CN107460090B (zh) | 一种鹿龟保健酒及其制备方法 | |
CN105664053A (zh) | 一种治疗维持性血液透析患者动静脉内瘘穿刺处皮肤硬结的中药组合物 | |
CN105267711A (zh) | 一种用于治疗眩晕症的药物制剂 | |
CN108096418A (zh) | 一种西洋参银杏胶囊的制备方法 | |
CN116270892B (zh) | 一种补益肾脏阴阳功能的配方及其原料制备方法 | |
CN102488212A (zh) | 一种用于改善睡眠的保健食品及其制备方法 | |
CN108339058A (zh) | 一种治疗酒糟鼻胶囊及其制备方法 | |
CN106344463A (zh) | 一种具有头皮护理功能的植物组合物及其制备方法与应用 | |
CN108066599B (zh) | 一种增强免疫力、辅助抗辐射的组合物及其制备方法和应用 | |
CN106466421A (zh) | 一种缓解近视眼症状的配方 | |
CN105727234A (zh) | 一种治疗脱发的中药组合物及其制备方法与应用 | |
WO2017173610A1 (zh) | 一种抗强直性脊柱炎联合免疫用药物及其制备方法、用途 | |
CN113713038A (zh) | 一种通下药物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180904 |