CN108463227A - 在造血干细胞中基因编辑的方法和组合物 - Google Patents

在造血干细胞中基因编辑的方法和组合物 Download PDF

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Publication number
CN108463227A
CN108463227A CN201680076538.8A CN201680076538A CN108463227A CN 108463227 A CN108463227 A CN 108463227A CN 201680076538 A CN201680076538 A CN 201680076538A CN 108463227 A CN108463227 A CN 108463227A
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cell
cells
method described
endogenous gene
modification
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S·吉尔
M·吉姆
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University of Pennsylvania Penn
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CN201680076538.8A 2015-11-04 2016-11-03 在造血干细胞中基因编辑的方法和组合物 Pending CN108463227A (zh)

Applications Claiming Priority (3)

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US201562250561P 2015-11-04 2015-11-04
US62/250,561 2015-11-04
PCT/US2016/060273 WO2017079400A1 (en) 2015-11-04 2016-11-03 Methods and compositions for gene editing in hematopoietic stem cells

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US (3) US10548922B2 (enExample)
EP (1) EP3370741B1 (enExample)
JP (3) JP6866385B2 (enExample)
KR (1) KR20180073679A (enExample)
CN (1) CN108463227A (enExample)
AU (2) AU2016349280B2 (enExample)
BR (1) BR112018009098A8 (enExample)
CA (1) CA3004053A1 (enExample)
CL (1) CL2018001198A1 (enExample)
EA (1) EA201891092A1 (enExample)
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CN109852627A (zh) * 2018-12-26 2019-06-07 中国人民解放军军事科学院军事医学研究院 用于CRISPRi系统的质粒、其构建方法及其在使鼠疫菌目的基因定向沉默中的应用
CN110662554A (zh) * 2017-02-28 2020-01-07 Vor生物制药股份有限公司 用于抑制谱系特异性蛋白质的组合物和方法
CN113194715A (zh) * 2018-10-31 2021-07-30 赫曼尼根公司 用于治疗癌症的材料和方法
WO2022228471A1 (zh) * 2021-04-27 2022-11-03 上海驯鹿生物技术有限公司 一种基因编辑的造血干细胞及其与car-t细胞的联合应用

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