CN108459008A - A kind of drug mixture homogeneity on-line measuring device - Google Patents
A kind of drug mixture homogeneity on-line measuring device Download PDFInfo
- Publication number
- CN108459008A CN108459008A CN201810317314.2A CN201810317314A CN108459008A CN 108459008 A CN108459008 A CN 108459008A CN 201810317314 A CN201810317314 A CN 201810317314A CN 108459008 A CN108459008 A CN 108459008A
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- station
- drug
- turntable
- control device
- line measuring
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
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- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The invention discloses a kind of drug mixture homogeneity on-line measuring devices,Including Raman spectrometer,Supporting rack,Fixed frame,Pedestal,Turntable,Display screen and control device,The turntable rotational installation is on the base,Support frame as described above is fixed on the rear end of the pedestal,The fixed frame is horizontally fixed on the upper end of support frame as described above,The fixed frame is rounded,Uniform intervals are equipped with first on the fixed frame,Two,Three,Four stations,First station and second station are mounted on infusion of medicine pipeline,The 3rd station is equipped with electric mixer,The detector of the Raman spectrometer is mounted on the 4th station,The turntable is equipped with the locating slot placed for drug container,The turntable is located at the underface of the fixed frame,The display screen is independently arranged,The Raman spectrometer is communicated to connect with the display screen,The device can detect in real time,Improve detection efficiency,Ensure detection accuracy.
Description
Technical field
The present invention relates to a kind of drug test device more particularly to a kind of drug mixture homogeneity on-line measuring devices.
Background technology
Drug batch mixing uniformity quality directly influences the drug effect of finished medicines, at this stage, the detection one of drug batch mixing mixing
As way be to be shut down at the time of thinking that batch mixing is uniform, then in mixing tank material different parts sampling carry out laboratory
Assay thinks that batch mixing reaches uniform if the content value of wherein certain ingredient is consistent, but due to the way
Poor in timeliness, it is time-consuming, laborious, production efficiency is reduced, the uniformity of last batch mixing can not be completely secured.
Invention content
In order to solve the above technical problems, the object of the present invention is to provide one kind to detect in real time, detection efficiency is improved, is protected
Demonstrate,prove the drug mixture homogeneity on-line measuring device of detection accuracy.
A kind of drug mixture homogeneity on-line measuring device proposed by the present invention, including Raman spectrometer, supporting rack, fixation
Frame, pedestal, turntable, display screen and control device, on the base, support frame as described above is fixed on for the turntable rotational installation
The rear end of the pedestal, the fixed frame are horizontally fixed on the upper end of support frame as described above, and the fixed frame is rounded, described
Uniform intervals are equipped with the first, second, third and fourth station on fixed frame, and first station and second station are mounted on drug note
Entering pipeline, the 3rd station is equipped with electric mixer, and the detector of the Raman spectrometer is mounted on the 4th station,
The turntable is equipped with the locating slot placed for drug container, and the turntable is located at the underface of the fixed frame, described aobvious
Display screen is independently arranged, and the Raman spectrometer is communicated to connect with the display screen, and the control device installation is on the base
And the rotation of the turntable is controlled, the electric mixer is communicated to connect with the control device.
Further, motor is installed, the turntable fixation is set in the shaft of the motor, described in the pedestal
Motor is communicated to connect with the control device.
Further, the infusion of medicine pipeline is to be equipped with solenoid valve, and the solenoid valve is communicated with the control device
Connection.
Further, the infusion of medicine pipeline is connected to by mateiral pump with external drug case, the mateiral pump with it is described
Control device communicates to connect.
Further, the 4th station is also equipped with electric lifting rod, and the electric mixer is mounted on described electronic
On elevating lever, the electric lifting rod is communicated to connect with the control device.
Further, inductor is mounted on first, second, third and fourth station, the inductor can incude drug appearance
Device, the inductor are communicated to connect with the control device.
Further, the control device includes integrated circuit board and several manipulation buttons.
According to the above aspect of the present invention, the present invention has at least the following advantages：Drug container is turned into finger by the rotation of turntable
Below fixed station, mixed medicine material will be needed to be injected into drug by the infusion of medicine pipeline on the first and second station and held
In device, the drug in drug container is stirred by the electric mixer in 3rd station, passes through the 4th after the completion of stirring
The detector of Raman spectrometer is detected the drug mixture homogeneity of drug container on station, to realize on-line checking,
The detection of the drug batch mixing uniformity may be implemented in the characteristic spectrum data that drug ingedient to be detected is acquired by raman laser technology,
It need not model, quickly, efficiently.It is combined by Raman spectrum data and spectrogram, testing result is more intuitive, in mixing process
Batch mixing uniformity situation is very clear, grasps in real time, improves the efficiency and accuracy rate of batch mixing, and accuracy rate is up to 95% or more,
Accuracy of detection can be realized within 0.01.
The device by control device set turntable each stage rotation distance and in each station residence time, and
The injection of logical control device control medicine material and the mixing time of electric mixer, if when testing result reality mixing is equal
Evenness is undesirable, can be turned back to 3rd station again and is again stirring for, so as to the mixing time that determination is best, operation letter
Singly, conveniently, detection speed is fast, and detection efficiency is high, ensures detection accuracy.
Above description is only the general introduction of technical solution of the present invention, in order to better understand the technical means of the present invention,
And can be implemented in accordance with the contents of the specification, below with presently preferred embodiments of the present invention and after coordinating attached drawing to be described in detail such as.
Description of the drawings
Fig. 1 is the structural schematic diagram of drug mixture homogeneity on-line measuring device of the present invention；
Fig. 2 is the structural schematic diagram of fixed frame in the present invention.
Specific implementation mode
With reference to the accompanying drawings and examples, the specific implementation mode of the present invention is described in further detail.Implement below
Example is not limited to the scope of the present invention for illustrating the present invention.
Embodiment：A kind of drug mixture homogeneity on-line measuring device, including Raman spectrometer 1, supporting rack 2, fixed frame
Frame 3, pedestal 4, turntable 5, display screen 6 and control device 7, on the base, support frame as described above is solid for the turntable rotational installation
It is scheduled on the rear end of the pedestal, the fixed frame is horizontally fixed on the upper end of support frame as described above, and the fixed frame is rounded,
Uniform intervals are equipped with the first, second, third and fourth station 8,9,10,11 on the fixed frame, and first station and second station are equal
Infusion of medicine pipeline 12 is installed, the 3rd station is equipped with electric mixer 13, the detector 14 of the Raman spectrometer
Mounted on the 4th station, the turntable is equipped with the locating slot 15 placed for drug container, and the turntable is located at described solid
Determine the underface of frame, the display screen is independently arranged, and the Raman spectrometer is communicated to connect with the display screen, the manipulation
The rotation of the turntable, the electric mixer and the control device communication link are installed on the base and controlled to device
It connects.
Motor 16 is installed in the pedestal, the turntable fixation is set in the shaft of the motor, the motor with
The control device communication connection.
The infusion of medicine pipeline is to be equipped with solenoid valve 17, and the solenoid valve is communicated to connect with the control device.
The infusion of medicine pipeline is connected to by mateiral pump 18 with external drug case 19, and the mateiral pump is filled with the manipulation
Set communication connection.
4th station is also equipped with electric lifting rod 20, and the electric mixer is mounted on the electric lifting rod
On, the electric lifting rod is communicated to connect with the control device.
Inductor 21 is mounted on first, second, third and fourth station, the inductor can incude drug container, described
Inductor is communicated to connect with the control device.
The control device includes integrated circuit board and several manipulation buttons.
The device is turned to drug container below specified station by the rotation of turntable, by the first and second station
Infusion of medicine pipeline mixed medicine material will be needed to be injected into drug container, pass through the electric mixer in 3rd station
Drug in drug container is stirred, drug is held by the detector of Raman spectrometer on the 4th station after the completion of stirring
The drug mixture homogeneity of device is detected, to realize on-line checking, by raman laser technology acquire drug to be detected at
The detection of the drug batch mixing uniformity may be implemented in the characteristic spectrum data divided, without modeling, quickly, efficiently.Pass through Raman spectrum number
It being combined according to spectrogram, testing result is more intuitive, very clear to the batch mixing uniformity situation in mixing process, grasps in real time,
The efficiency and accuracy rate of batch mixing are improved, accuracy rate is up to 95% or more, and accuracy of detection can be realized within 0.01.
The device by control device set turntable each stage rotation distance and in each station residence time, and
The injection of logical control device control medicine material and the mixing time of electric mixer, if when testing result reality mixing is equal
Evenness is undesirable, can be turned back to 3rd station again and is again stirring for, so as to the mixing time that determination is best, operation letter
Singly, conveniently, detection speed is fast, and detection efficiency is high, ensures detection accuracy.
The above is only a preferred embodiment of the present invention, it is not intended to restrict the invention, it is noted that for this skill
For the those of ordinary skill in art field, without departing from the technical principles of the invention, can also make it is several improvement and
Modification, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (7)
1. a kind of drug mixture homogeneity on-line measuring device, it is characterised in that：Including Raman spectrometer, supporting rack, fixed frame
Frame, pedestal, turntable, display screen and control device, on the base, support frame as described above is fixed on institute for the turntable rotational installation
The rear end of pedestal is stated, the fixed frame is horizontally fixed on the upper end of support frame as described above, and the fixed frame is rounded, described solid
Determine uniform intervals on frame and be equipped with the first, second, third and fourth station, first station and second station are mounted on infusion of medicine
Pipeline, the 3rd station are equipped with electric mixer, and the detector of the Raman spectrometer is mounted on the 4th station, institute
It states turntable and is equipped with the locating slot placed for drug container, the turntable is located at the underface of the fixed frame, the display
Screen is independently arranged, and the Raman spectrometer is communicated to connect with the display screen, and the control device is installed on the base simultaneously
The rotation of the turntable is controlled, the electric mixer is communicated to connect with the control device.
2. a kind of drug mixture homogeneity on-line measuring device according to claim 1, it is characterised in that：In the pedestal
Motor is installed, the turntable fixation is set in the shaft of the motor, and the motor is communicated to connect with the control device.
3. a kind of drug mixture homogeneity on-line measuring device according to claim 2, it is characterised in that：The drug note
It is to be equipped with solenoid valve to enter pipeline, and the solenoid valve is communicated to connect with the control device.
4. a kind of drug mixture homogeneity on-line measuring device according to claim 3, it is characterised in that：The drug note
Enter pipeline to be connected to external drug case by mateiral pump, the mateiral pump is communicated to connect with the control device.
5. a kind of drug mixture homogeneity on-line measuring device according to claim 4, it is characterised in that：4th work
Position is also equipped with electric lifting rod, and the electric mixer is mounted on the electric lifting rod, the electric lifting rod and institute
State control device communication connection.
6. a kind of drug mixture homogeneity on-line measuring device according to claim 5, it is characterised in that：Described first,
Two, inductor is mounted on three, four stations, the inductor can incude drug container, and the inductor is filled with the manipulation
Set communication connection.
7. a kind of drug mixture homogeneity on-line measuring device according to claim 6, it is characterised in that：The manipulation dress
It sets including integrated circuit board and several manipulation buttons.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810317314.2A CN108459008A (en) | 2018-04-10 | 2018-04-10 | A kind of drug mixture homogeneity on-line measuring device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810317314.2A CN108459008A (en) | 2018-04-10 | 2018-04-10 | A kind of drug mixture homogeneity on-line measuring device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108459008A true CN108459008A (en) | 2018-08-28 |
Family
ID=63234510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810317314.2A Withdrawn CN108459008A (en) | 2018-04-10 | 2018-04-10 | A kind of drug mixture homogeneity on-line measuring device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108459008A (en) |
-
2018
- 2018-04-10 CN CN201810317314.2A patent/CN108459008A/en not_active Withdrawn
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| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180828 |