CN108169477A - A kind of magnetic enzyme exempts from the pipetting device of quantitative fluorescence analysis instrument - Google Patents
A kind of magnetic enzyme exempts from the pipetting device of quantitative fluorescence analysis instrument Download PDFInfo
- Publication number
- CN108169477A CN108169477A CN201711258067.5A CN201711258067A CN108169477A CN 108169477 A CN108169477 A CN 108169477A CN 201711258067 A CN201711258067 A CN 201711258067A CN 108169477 A CN108169477 A CN 108169477A
- Authority
- CN
- China
- Prior art keywords
- component
- connecting rod
- analysis instrument
- fluorescence analysis
- exempts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004190 Enzymes Human genes 0.000 title claims abstract description 17
- 108090000790 Enzymes Proteins 0.000 title claims abstract description 17
- 238000012921 fluorescence analysis Methods 0.000 title claims abstract description 17
- 238000005213 imbibition Methods 0.000 claims abstract description 31
- 239000007788 liquid Substances 0.000 claims abstract description 21
- 230000005540 biological transmission Effects 0.000 claims abstract description 10
- 239000012085 test solution Substances 0.000 claims description 18
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000011324 bead Substances 0.000 abstract description 10
- 238000013461 design Methods 0.000 abstract description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- BGPVFRJUHWVFKM-UHFFFAOYSA-N N1=C2C=CC=CC2=[N+]([O-])C1(CC1)CCC21N=C1C=CC=CC1=[N+]2[O-] Chemical compound N1=C2C=CC=CC2=[N+]([O-])C1(CC1)CCC21N=C1C=CC=CC1=[N+]2[O-] BGPVFRJUHWVFKM-UHFFFAOYSA-N 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses the pipetting devices that a kind of magnetic enzyme exempts from quantitative fluorescence analysis instrument, including bearing support, it is provided on the bearing support and moves forward and backward component, described move forward and backward is provided with board rack on component, up and down motion component is provided on the bearing support, liquid relief component is provided on the up and down motion component, electric rotating machine is provided on the bearing support, the main shaft of the electric rotating machine is hinged with connecting rod by transmission mechanism, the end of the connecting rod is provided with magnet, the electric rotating machine drives connecting rod to be rotated around hinge joint, so that magnet is separate or close to board rack；Board rack is using component is moved forward and backward in imbibition station and the back-and-forth motion of liquid relief station, imbibition, and connecting rod band moving magnet is close to board rack so that the magnetic bead in board is assembled forward, facilitates carry out imbibition；When liquid relief, connecting rod band moving magnet is far from board rack so that magnetic bead resets, smart structural design, substantially increases the efficiency of imbibition and liquid relief.
Description
Technical field
The present invention relates to the liquid relief machines that chemical apparatuses apparatus field more particularly to a kind of magnetic enzyme exempt from quantitative fluorescence analysis instrument
Structure.
Background technology
It is using luminescent system and immunoassay method, to serum, blood plasma or other bodies that magnetic enzyme, which exempts from quantitative fluorescence analysis instrument,
Various analytes in liquid carry out the instrument of quantitative detection.Reagent lath equipped with various test solutions is mating to be entered in reaction instrument,
Test solution in liquid to be checked and reagent lath is mixed, then reagent lath is observed using detecting system, obtains inspection
Survey result.Common fluorescence reaction instrument is exactly that the test solution in board is drawn using fluid suction head, but to magnetic bead test solution into
During row imbibition, board does not have evenly mixing device, and magnetic bead test solution easily precipitates in board so that is not easy to pick up when drawing magnetic bead, try
Liquid is unevenly distributed the result for also influencing detection.
Invention content
In order to overcome the above-mentioned deficiencies of the prior art, the present invention provides magnetic bead can be picked up during a kind of imbibition, ensure imbibition
It is smoothed out, the magnetic enzyme for improving processing efficiency exempts from the pipetting device of quantitative fluorescence analysis instrument.
To achieve these goals, the technical solution adopted by the present invention is：
A kind of magnetic enzyme exempts from the pipetting device of quantitative fluorescence analysis instrument, including bearing support, is provided on the bearing support front and rear
Moving parts, described move forward and backward are provided with board rack, up and down motion component, institute are provided on the bearing support on component
It states and liquid relief component is provided on up and down motion component, electric rotating machine, the main shaft of the electric rotating machine are provided on the bearing support
Connecting rod is hinged with by transmission mechanism, the end of the connecting rod is provided with magnet, and the electric rotating machine drives connecting rod around hinge joint
Rotation so that magnet is separate or close to board rack.
As being further improved for said program, the transmission mechanism is gear set, and gear set includes being set in electric rotating
First gear on machine, hinged second gear and the transmission gear of the connection first gear and second gear with connecting rod.
As being further improved for said program, the liquid relief component includes the installation being arranged on up and down motion component
Block is fixed with imbibition work on the mounting blocks, and the lower end of the imbibition piston is provided with suction nozzle seat, is provided in the suction nozzle seat
The suction nozzle being connect with imbibition piston.
As being further improved for said program, the upper end of the suction nozzle stretches out the suction nozzle seat and is arranged with spring, institute
Spring is stated to be pressed between imbibition piston and suction nozzle seat.
As being further improved for said program, the up and down motion component includes vertical slide rail, in the vertical slide rail
Vertical slipper is provided with, the mounting blocks are fixed on vertical slipper, and the mounting blocks are connected with the first driving motor.
As being further improved for said program, the component that moves forward and backward includes horizontal slide rail, on the horizontal slide rail
Equipped with horizontal slider, the board rack is fixed on the horizontal slider, and the board rack is connected with the second driving
Motor.
As being further improved for said program, board heating plate is equipped in the board rack.
As being further improved for said program, test solution heating plate is provided in the suction nozzle seat.
Beneficial effects of the present invention：
A kind of magnetic enzyme of the present invention exempts from the pipetting device of quantitative fluorescence analysis instrument, and board is placed on board rack, is utilized
Component is moved forward and backward in imbibition station and the back-and-forth motion of liquid relief station, imbibition, connecting rod band moving magnet makes close to board rack
The magnetic bead obtained in board is assembled forward, facilitates carry out imbibition, can play the effect of stirring test solution so that test solution distribution is more equal
It is even；When liquid relief, connecting rod band moving magnet is far from board rack so that magnetic bead resets, and smart structural design substantially increases suction
The efficiency of liquid and liquid relief.
Description of the drawings
To describe the technical solutions in the embodiments of the present invention more clearly, make required in being described below to embodiment
Attached drawing is briefly described.Obviously, described attached drawing is the part of the embodiment of the present invention rather than all implements
Example, without creative efforts, other that can also be obtained according to these attached drawings are set those skilled in the art
Meter scheme and attached drawing：
Fig. 1 is present pre-ferred embodiments structure diagram；
Fig. 2 is present pre-ferred embodiments structure diagram；
Fig. 3 is present pre-ferred embodiments structure diagram.
Specific embodiment
The technique effect of the design of the present invention, concrete structure and generation is carried out below with reference to embodiment and attached drawing clear
Chu is fully described by, to be completely understood by the purpose of the present invention, feature and effect.Obviously, described embodiment is this hair
Bright part of the embodiment rather than whole embodiments, based on the embodiment of the present invention, those skilled in the art is not paying
The other embodiment obtained under the premise of creative work, belongs to the scope of protection of the invention.
Referring to figs. 1 to Fig. 3, a kind of magnetic enzyme exempts from the pipetting device of quantitative fluorescence analysis instrument, including bearing support 1, the bearing
It is provided on frame 1 and moves forward and backward component, described move forward and backward is provided with board rack 2 on component, set on the bearing support 1
There is up and down motion component, liquid relief component be provided on the up and down motion component, electric rotating machine 3 is provided on the bearing support 1,
The main shaft of the electric rotating machine 3 is hinged with connecting rod 4 by transmission mechanism, and the end of the connecting rod 4 is provided with magnet 5, the rotation
Rotating motor 3 drives connecting rod 4 to be rotated around hinge joint so that magnet 5 is separate or close to board rack 2.
The transmission mechanism is gear set, and gear set includes the first gear 6 being set on electric rotating machine 3, cut with scissors with connecting rod 4
The second gear 7 and the transmission gear 8 of the connection first gear 6 and second gear 7 connect, electric rotating machine 3 are rotated, are driven
Transmission gear 8 rotates, so that second gear 7 rotates, connecting rod 4 is driven to rotate.
Board is placed on board rack 2, is moved forward and backward using component is moved forward and backward in imbibition station and liquid relief station,
The component that moves forward and backward includes horizontal slide rail 17, and the horizontal slide rail 17 is equipped with horizontal slider 18, the board rack 2
It is fixed on the horizontal slider 18, the board rack 2 is connected with the second driving motor 19.During imbibition, connecting rod 4 drives magnetic
Iron 5 is close to board rack 2 so that and the magnetic bead in board is assembled forward, facilitates carry out imbibition, plays the effect of stirring test solution,
So that test solution distribution is more uniform.When the test solution of absorption is expelled in the detect tank of board, connecting rod 4 is with moving magnet 5 far from plate
Card rack 2 so that magnetic bead resets, smart structural design, substantially increases the efficiency of imbibition and liquid relief.
The liquid relief component includes the mounting blocks 9 being arranged on up and down motion component, and imbibition is fixed on the mounting blocks 9
Piston 10, the lower end of the imbibition piston 10 are provided with suction nozzle seat 11, are provided in the suction nozzle seat 11 and connect with imbibition piston 10
The suction nozzle 12 connect, the upper end of the suction nozzle 12 stretch out the suction nozzle seat 11 and are arranged with spring 13, and the spring 13 is pressed on suction
Between liquid piston 10 and suction nozzle seat 11.
The up and down motion component includes vertical slide rail 14, and vertical slipper, the peace are provided in the vertical slide rail 14
Dress block 9 is fixed on vertical slipper 15, and the mounting blocks 9 are connected with the first driving motor 16.
Mounting blocks 9 move up and down along vertical slide rail 14, and the mounting blocks 9 move downward during imbibition so that in suction nozzle seat 11
Suction nozzle 12 extend downwardly into the test solution slot of board, then the piston block of imbibition piston 10 moves upwards, and suction nozzle 12 is drawn up
Test solution completes imbibition.After the completion of imbibition, mounting blocks 9 move upwards, and board are facilitated to move backward so that the empty slot in board is in
12 lower section of suction nozzle, then the piston block of imbibition piston 10 moves downward so that the test solution in suction nozzle 12 is expelled in empty slot, entirely
Imbibition discharge opeing process is automatically finished, and processing efficiency greatly improves.
Board heating plate is equipped in the board rack 2, test solution heating plate 20 is provided in the suction nozzle seat 11 so that
Test solution is constantly in a stationary temperature in process, will not cool down, and ensures that the temperature of reaction is in ideal range
It is interior so that the reaction result of test solution is relatively reliable.
It is that presently preferred embodiments of the present invention is illustrated above, but the invention is not limited to the implementation
Example, those skilled in the art can also make various equivalent modifications under the premise of without prejudice to spirit of the invention or replace
It changes, these equivalent modifications or replacement are all contained in the application claim limited range.
Claims (8)
1. a kind of magnetic enzyme exempts from the pipetting device of quantitative fluorescence analysis instrument, including bearing support, it is characterised in that：It is set on the bearing support
It is equipped with and moves forward and backward component, described move forward and backward is provided with board rack on component, be provided on the bearing support and transport up and down
Component is moved, liquid relief component is provided on the up and down motion component, electric rotating machine, the electric rotating is provided on the bearing support
The main shaft of machine is hinged with connecting rod by transmission mechanism, and the end of the connecting rod is provided with magnet, and the electric rotating machine drives connecting rod
It is rotated around hinge joint so that magnet is separate or close to board rack.
2. magnetic enzyme according to claim 1 exempts from the pipetting device of quantitative fluorescence analysis instrument, it is characterised in that：The driver
Structure is gear set, and gear set includes the first gear being set on electric rotating machine, hinged second gear and connection with connecting rod
The transmission gear of the first gear and second gear.
3. magnetic enzyme according to claim 1 exempts from the pipetting device of quantitative fluorescence analysis instrument, it is characterised in that：The liquid relief group
Part includes the mounting blocks being arranged on up and down motion component, and imbibition piston is fixed on the mounting blocks, the imbibition piston
Lower end is provided with suction nozzle seat, and the suction nozzle being connect with imbibition piston is provided in the suction nozzle seat.
4. magnetic enzyme according to claim 3 exempts from the pipetting device of quantitative fluorescence analysis instrument, it is characterised in that：The suction nozzle
Upper end stretches out the suction nozzle seat and is arranged with spring, and the spring is pressed between imbibition piston and suction nozzle seat.
5. magnetic enzyme according to claim 3 exempts from the pipetting device of quantitative fluorescence analysis instrument, it is characterised in that：It is described to transport up and down
Dynamic component includes vertical slide rail, is provided with vertical slipper in the vertical slide rail, the mounting blocks are fixed on vertical slipper, institute
It states mounting blocks and is connected with the first driving motor.
6. magnetic enzyme according to claim 1 exempts from the pipetting device of quantitative fluorescence analysis instrument, it is characterised in that：The front and rear fortune
Dynamic component includes horizontal slide rail, and the horizontal slide rail is equipped with horizontal slider, and the board rack is fixed on described horizontal sliding
On block, the board rack is connected with the second driving motor.
7. magnetic enzyme according to claim 1 exempts from the pipetting device of quantitative fluorescence analysis instrument, it is characterised in that：The board is put
It puts and board heating plate is equipped in frame.
8. magnetic enzyme according to claim 3 exempts from the pipetting device of quantitative fluorescence analysis instrument, it is characterised in that：The suction nozzle seat
Inside it is provided with test solution heating plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711258067.5A CN108169477A (en) | 2017-12-04 | 2017-12-04 | A kind of magnetic enzyme exempts from the pipetting device of quantitative fluorescence analysis instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711258067.5A CN108169477A (en) | 2017-12-04 | 2017-12-04 | A kind of magnetic enzyme exempts from the pipetting device of quantitative fluorescence analysis instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108169477A true CN108169477A (en) | 2018-06-15 |
Family
ID=62524282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711258067.5A Pending CN108169477A (en) | 2017-12-04 | 2017-12-04 | A kind of magnetic enzyme exempts from the pipetting device of quantitative fluorescence analysis instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108169477A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113390677A (en) * | 2021-04-27 | 2021-09-14 | 顾心梅 | Lactobacillus casei zymotic fluid automatic extraction element for feed processing |
| CN116500265A (en) * | 2023-06-25 | 2023-07-28 | 山东益生种畜禽股份有限公司 | Pullorum source phage detection device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06313767A (en) * | 1993-04-28 | 1994-11-08 | Medeika Tec Kk | Inspection apparatus for blood and the like using magnetic bead |
| US20120258026A1 (en) * | 2011-04-08 | 2012-10-11 | Uwe Naumann | Pipetting device |
| CN103586095A (en) * | 2013-11-26 | 2014-02-19 | 东南大学 | Multichannel pipettor |
| CN105624032A (en) * | 2016-02-25 | 2016-06-01 | 东南大学 | Field rapid pathogen detection system |
| CN207601092U (en) * | 2017-12-04 | 2018-07-10 | 珠海迪尔生物工程有限公司 | A kind of magnetic enzyme exempts from the pipetting device of quantitative fluorescence analysis instrument |
-
2017
- 2017-12-04 CN CN201711258067.5A patent/CN108169477A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06313767A (en) * | 1993-04-28 | 1994-11-08 | Medeika Tec Kk | Inspection apparatus for blood and the like using magnetic bead |
| US20120258026A1 (en) * | 2011-04-08 | 2012-10-11 | Uwe Naumann | Pipetting device |
| CN103586095A (en) * | 2013-11-26 | 2014-02-19 | 东南大学 | Multichannel pipettor |
| CN105624032A (en) * | 2016-02-25 | 2016-06-01 | 东南大学 | Field rapid pathogen detection system |
| CN207601092U (en) * | 2017-12-04 | 2018-07-10 | 珠海迪尔生物工程有限公司 | A kind of magnetic enzyme exempts from the pipetting device of quantitative fluorescence analysis instrument |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113390677A (en) * | 2021-04-27 | 2021-09-14 | 顾心梅 | Lactobacillus casei zymotic fluid automatic extraction element for feed processing |
| CN116500265A (en) * | 2023-06-25 | 2023-07-28 | 山东益生种畜禽股份有限公司 | Pullorum source phage detection device |
| CN116500265B (en) * | 2023-06-25 | 2023-08-29 | 山东益生种畜禽股份有限公司 | Pullorum source phage detection device |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 519041 No. 19 Golden Coast Road, San Zao Town, Jin Wan District, Zhuhai, Guangdong Applicant after: Zhuhai deer Bioengineering Co.,Ltd. Address before: 519041 No. 19 Golden Coast Road, San Zao Town, Jin Wan District, Zhuhai, Guangdong Applicant before: ZHUHAI DL MEDICAL BIOTECH Co.,Ltd. |