CN108444854B - Virus inactivation monitor - Google Patents
Virus inactivation monitor Download PDFInfo
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- CN108444854B CN108444854B CN201711404547.8A CN201711404547A CN108444854B CN 108444854 B CN108444854 B CN 108444854B CN 201711404547 A CN201711404547 A CN 201711404547A CN 108444854 B CN108444854 B CN 108444854B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N5/00—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0017—Filtration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0076—Radiation using a photocatalyst or photosensitiser
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/22—Blood or products thereof
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Abstract
The invention discloses a virus inactivation monitor, which comprises a machine body, and an upper computer, a filtering bracket device, a weighing device and a heat sealing device which are arranged on the machine body, wherein the filtering bracket device is used for suspending and supporting a blood bag in the plasma virus inactivation and filtration treatment; the upper computer is electrically connected with the weighing device and the heat sealing device, and the weighing device is used for weighing the plasma finished product bag according to a weighing instruction sent by the upper computer and locking the weighed weight after the weight of the plasma finished product bag is stable; the upper computer controls the heat sealing device to heat seal the inlet and outlet pipes of the plasma finished product bag after the weighing device locks the weight of the plasma finished product bag; and after the heat sealing device completes the heat sealing of the inlet and outlet pipes of the plasma finished product bag, the upper computer controls the weighing device to release the weight locking so as to weigh the next plasma finished product bag. The virus inactivation monitor ensures the stability of weighing and heat sealing operation in the process of manufacturing the finished plasma bags, reduces the space occupation of equipment and improves the overall efficiency.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to a virus inactivation monitor.
Background
In order to ensure the safety of blood, virus inactivation treatment is required in the process of preparing blood plasma. The method adopted by the existing plasma virus inactivation is a methylene blue photochemical inactivation method, and the specific operation method is as follows: firstly, hanging an original plasma bag on a hook disc of an inactivation support device, connecting the original plasma bag with a plasma transfer bag below the original plasma bag through a conduit, and arranging a methylene blue powder box between the original plasma bag and the plasma transfer bag; then, the plasma transfer bag added with methylene blue is illuminated, so that the virus completely loses the penetrating, copying and infecting abilities; after the illumination is finished, the plasma transfer bag is hung on a hook disc of the inactivation support device and is connected with a plasma finished product bag below through a conduit, and a filter for filtering methylene blue from plasma is arranged between the plasma transfer bag and the plasma finished product bag. There is some loss due to the two passes of plasma from one blood bag to another during the virus inactivation process. The content of the standard plasma finished product bags is 200ml +/-10%, 150ml +/-10% and 100ml +/-10%, so that the plasma is required to be weighed to be made into the plasma finished product bags with the standard content. If the content of the plasma is lower than the former standard, for example, if the content of only 170ml is not more than 200ml +/-10%, part of the plasma is squeezed back into the plasma transfer bag to form a 150ml +/-10% standard plasma finished product bag, and finally the conduit of the plasma finished product bag with the content reaching the standard is sealed.
In the prior art, the production process of the plasma finished product bag is as follows: separating plasma from whole blood, then taking the plasma to an inactivation bracket device for virus inactivation treatment, uniformly transporting the plasma finished product bags subjected to virus inactivation treatment to one place by a cart for weighing, and then transporting the plasma finished product bags with the content reaching the standard to another place for heat sealing. This weighing and heat sealing of plasma blood bags has the following drawbacks: 1. the weighing and heat sealing method has human errors, for example, the weighing data is unstable, the finished plasma bag is taken out for heat sealing, or the heat sealing is not completed, the finished plasma bag is taken out, and the next finished plasma bag is weighed. 2. Filter support device, weighing device and heat seal device three separately set up in the position of 3 differences, not only account for the space, cause easily and put in a jumble, the operator need make a round trip to move between the three always in addition, has influenced whole efficiency.
Disclosure of Invention
The invention mainly aims to provide a virus inactivation monitor, which ensures the stability of weighing and heat sealing operation in the process of manufacturing a finished plasma bag, reduces the space occupation of equipment and improves the overall efficiency.
In order to achieve the purpose, the virus inactivation monitor provided by the invention comprises a machine body, and an upper computer, a filtering bracket device, a weighing device and a heat sealing device which are arranged on the machine body, wherein the filtering bracket device is used for suspending and supporting a blood bag in the plasma virus inactivation and filtration treatment; the upper computer is electrically connected with the weighing device and the heat sealing device, and the weighing device is used for weighing the finished plasma bags according to a weighing instruction sent by the upper computer and locking the weighed weight after the weight of the finished plasma bags is stable; the upper computer sends a heat sealing instruction to the heat sealing device after the weighing device locks the weight of the plasma finished product bag, so that the heat sealing device carries out heat sealing on an inlet pipe and an outlet pipe of the plasma finished product bag; and the upper computer controls the weighing device to release weight locking after the heat sealing device finishes the heat sealing of the inlet and outlet pipes of the plasma finished product bag so as to weigh the next plasma finished product bag.
Preferably, the weighing device weighs the finished plasma bag according to a weighing instruction sent by the upper computer, and the step of locking the weighed weight after the weight of the finished plasma bag is stable comprises:
s1, acquiring the current weight of the finished plasma bag as an initial weight value, and starting weight confirmation countdown with preset time duration;
s2, acquiring the weight of the finished plasma product bag as a middle weight value every other first time interval in the weight confirmation countdown;
s3, if the difference value between the intermediate weight value and the initial weight value exceeds a first threshold value, re-executing the step S1;
s4, if the difference value between each intermediate weight value and the initial weight value is less than or equal to the first threshold value in the weight confirmation countdown, locking the weight of the finished plasma bag as the initial weight value, and feeding back the initial weight value to the upper computer.
Preferably, after receiving the initial weight value and finishing sending the heat sealing instruction to the heating device, if receiving a re-weighing request, the upper computer sends a heat sealing cancellation instruction to the heating device and sends a weighing instruction to the weighing device, so that the weighing device reweighs the finished plasma bags.
Preferably, the weighing device comprises a first processor, a first communication unit and a first pressure sensor electrically connected with the first processor, wherein the first communication unit is connected between the first processor and the upper computer and used for information transmission between the first processor and the upper computer; the first pressure sensor is used for detecting the gravity of the finished plasma bag and feeding the detected gravity back to the first processor; the first processor controls the first pressure sensor to start to detect the gravity of the finished plasma product bag according to the weighing instruction sent by the upper computer, and determines the weight of the finished plasma product bag according to the gravity fed back by the first pressure sensor.
Preferably, the weighing device further comprises a nixie tube and an indicator light, wherein the nixie tube and the indicator light are respectively electrically connected with the first processor, the nixie tube is used for displaying the weight of the finished plasma product bag obtained by the first processor according to the gravity detected by the first pressure sensor, and the indicator light is used for displaying the weight locking state of the weighing device.
Preferably, the heat sealing device comprises a second processor, and a second communication unit, a light sensation detection unit, a heat sealing caliper and a high-frequency plate which are respectively electrically connected with the second processor; the second communication unit is used for information transmission between the second processor and the upper computer; the light sensation detection unit is used for detecting whether an inlet pipe and an outlet pipe of the finished plasma bag are placed in the heat seal caliper or not; the high-frequency plate is used for outputting power to the heat sealing calipers so as to drive the heat sealing calipers to heat seal the inlet and outlet pipes of the plasma finished product bag;
the step of heat-sealing the inlet and outlet pipes of the plasma finished product bag by the heat-sealing device comprises the following steps:
after receiving a heat sealing instruction sent by an upper computer, the second processor controls the light sensation detection unit to start so as to detect whether an inlet pipe and an outlet pipe of a finished plasma bag are placed in the heat sealing calipers or not;
and after the inlet and outlet pipe of the plasma finished product bag is determined to be placed into the heat sealing calipers, the second processor controls the high-frequency plate to be started so as to drive the heat sealing calipers to carry out heat sealing on the inlet and outlet pipe of the plasma finished product bag.
Preferably, the heat sealing device further comprises a current detection unit, wherein the current detection unit is electrically connected with the second processor and the high-frequency plate respectively; the current detection unit detects the input current of the high-frequency plate when the high-frequency plate works, and feeds the detected input current back to the second processor; after receiving the input current fed back by the current detection unit, the second processor calculates the input power of the high-frequency board according to the input current and analyzes whether the input power is within a preset normal power range; and when the input power of the high-frequency board is not within the preset normal power range obtained through analysis, the second processor performs exception alarm processing.
Preferably, the machine body is further provided with a scanning device electrically connected with the upper computer, the scanning device is used for scanning marking information of the finished plasma bags and marks of operators and feeding the scanning information back to the upper computer, and the upper computer stores the received scanning information.
Preferably, the support filtering device comprises a top weighing plate, a second pressure sensor and a plurality of hooks for hanging the original plasma bag are arranged on the top weighing plate, and the hooks are connected with the second pressure sensor; the second pressure sensor is electrically connected with an upper computer and is used for detecting the total gravity of the blood bag hung on the top weighing plate and feeding the detected gravity back to the upper computer;
in the plasma virus inactivation and filtration treatment, the upper computer controls the second pressure sensor to detect the total gravity of the blood bag suspended on the top weighing plate at regular time, and analyzes whether the difference value of the total gravity of two adjacent times detected by the second pressure sensor is within a preset first difference value range; and if the difference value of the total gravity exceeds the first difference value range, the upper computer determines that the filtration of the plasma is abnormal, and the abnormal filtration alarm is carried out.
Preferably, after the weighing device locks the weight, the upper computer determines the weight reduction amount of the blood bag suspended on the top weighing plate in the plasma filtering process according to the gravity fed back by the second pressure sensor, and analyzes whether the difference value between the weight reduction amount and the weight of the finished plasma bag locked by the weighing device is within a preset second difference value range; and if the difference exceeds the second difference range, the upper computer determines that the filtration of the plasma is abnormal and carries out filtration abnormity alarm.
According to the technical scheme, the filtering support device, the weighing device and the heat sealing device are arranged on the machine body in an integrated design, so that the virus inactivation monitor is integrated, compared with a mode that the filtering support device, the weighing device and the heat sealing device are arranged separately in the prior art, the virus inactivation monitor effectively reduces the occupied space, avoids the problem of messy arrangement caused by the fact that the filtering support device, the weighing device and the heat sealing device are arranged separately, an operator does not need to walk back and forth, and the overall manufacturing efficiency is higher. In addition, the weight of the plasma finished product bag is locked by the weighing device after the weighed plasma finished product bag is stable, the upper computer sends a heat sealing instruction to control the heat sealing device to be started after the weighing device feeds back the weight locking so as to heat seal the inlet and outlet pipes of the plasma finished product bag, and the upper computer sends an unlocking instruction to control the weighing device to be unlocked after the heat sealing device finishes the heat sealing of the plasma finished product bag, so that the weighing device can weigh a new plasma finished product bag; therefore, the situation that the blood plasma finished product bag is taken away to be subjected to weighing work on the next blood plasma finished product bag when the weighing data of the blood plasma finished product bag is not stable and the heat seal is not completed is avoided.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
FIG. 1 is a schematic diagram of module connections of an embodiment of the virus inactivation monitor of the present invention;
FIG. 2 is a flow chart of a weighing apparatus according to an embodiment of the monitor for viral inactivation of the present invention;
FIG. 3 is a block diagram of a weighing apparatus of an embodiment of the monitor for viral inactivation of the present invention;
FIG. 4 is a block diagram of a heat sealing apparatus according to an embodiment of the present invention;
FIG. 5 is a heat sealing flow diagram of a heat sealing apparatus according to an embodiment of the present invention;
FIG. 6 is a schematic diagram of module connections of a second embodiment of the virus inactivation monitor of the present invention;
FIG. 7 is a schematic diagram of module connections of three embodiments of the virus inactivation monitor of the present invention.
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that all the directional indicators (such as up, down, left, right, front, and rear … …) in the embodiment of the present invention are only used to explain the relative position relationship between the components, the movement situation, etc. in a specific posture (as shown in the drawing), and if the specific posture is changed, the directional indicator is changed accordingly.
The invention provides a virus inactivation monitor, which is used for manufacturing a plasma finished product bag.
Referring to fig. 1, the virus inactivation monitor of the present embodiment includes a body (not shown), and an upper computer 10, a filtering support device (not shown), a weighing device 20, and a heat sealing device 30, which are disposed on the body, wherein the filtering support device is used to hang and support a blood bag (including a raw plasma bag, a plasma transfer bag, and a plasma finished product bag, specifically including hanging the raw plasma bag and the plasma transfer bag, and supporting the plasma transfer bag and the plasma finished product bag) during a plasma virus inactivation filtering process; the upper computer 10 is electrically connected with the weighing device 20 and the heat sealing device 30, and the weighing device 20 is used for weighing the plasma finished product bag according to a weighing instruction sent by the upper computer 10 and locking the weighed weight after the weight of the plasma finished product bag is stable; the upper computer 10 sends a heat sealing instruction to the heat sealing device 30 after the weighing device 20 locks the weight of the plasma finished product bag, so that the heat sealing device 30 carries out heat sealing on the inlet and outlet pipes of the plasma finished product bag; the upper computer 10 controls the weighing device 20 to release the weight lock after the heat sealing device 30 completes the heat sealing of the inlet and outlet pipes of the plasma finished product bag, so as to weigh the next plasma finished product bag.
The process of manufacturing the plasma finished product bag by using the virus inactivation monitor of the embodiment is as follows:
1. first, viral inactivation and filtration treatment of plasma: on the filtering bracket device, plasma in the suspended original plasma bag passes through the methylene blue powder box and then enters the supported plasma transfer bag, and the plasma transfer bag is subjected to illumination treatment; after the illumination of the plasma transfer bag is finished, the plasma transfer bag is hung, and plasma in the plasma transfer bag enters the supported plasma finished product bag through the filter.
2. After the operator puts the finished plasma bag on the weighing device 20, presses the start key, and the host computer 10 sends the instruction of weighing to the weighing device 20, and the weighing device 20 starts to weigh this finished plasma bag, and after the weight of finished plasma bag is stable, the weighing device 20 locks the weight of finished plasma bag at this stable weight value to the weight value that will lock is fed back to the host computer 10.
3. The upper computer 10 stores the weight value after receiving the weight value fed back by the weighing device 20, sends a heat sealing instruction to the heat sealing device 30, and controls the heat sealing device 30 to heat seal the inlet and outlet pipes of the plasma finished product bag;
4. after the heat sealing device 30 completes heat sealing of the inlet and outlet tubes of the plasma finished product bag (i.e., the current plasma finished product bag is manufactured), the upper computer 10 sends an unlocking instruction to the weighing device 20, so that the weighing device 20 releases the weight locking state, and restores the weighing state, and an operator can take the plasma finished product bag for storage and weigh the next blood bag finished product bag.
In this embodiment, the main body is further provided with a display device (not shown), the display device is electrically connected to the upper computer 10, and the upper computer 10 displays data related to the blood bag (for example, weight data, blood bag label, etc.) on the display device; the display device of this embodiment is preferably a touch screen, and the start key of the upper computer 10 may be a physical key or a virtual key disposed on the touch screen.
This embodiment virus inactivation monitor, through adopting the integrative design of all establishing on the fuselage with filter support device, weighing device 20 and heat seal device 30 three for virus inactivation monitor wholeization, the mode that will above the three separately set up that compares prior art uses, this scheme is effectual has reduced occupation space, avoided the three separately set up the mixed and disorderly problem of putting that leads to the fact, the operator need not to make a round trip to walk about moreover, the whole efficiency of preparation is higher. In addition, in the monitor for virus inactivation of the present embodiment, the weighing device 20 locks the weight of the plasma finished product bag after the weighed plasma finished product bag has stabilized weight, the upper computer 10 sends a heat-sealing instruction to control the start of the heat-sealing device 30 after the weight is locked by the weighing device 20, so as to heat-seal the inlet and outlet pipes of the plasma finished product bag, and the upper computer 10 sends an unlocking instruction to control the unlocking of the weighing device 20 after the heat-sealing device 30 completes the heat-sealing of the plasma finished product bag, so that the weighing device 20 can weigh a new plasma finished product bag; therefore, the situation that the blood plasma finished product bag is taken away to be subjected to weighing work on the next blood plasma finished product bag when the weighing data of the blood plasma finished product bag is not stable and the heat seal is not completed is avoided.
Further, referring to fig. 2, in this embodiment, the step of weighing the finished plasma bag by the weighing device 20 according to the weighing instruction sent by the upper computer 10, and locking the weighed weight after the weight of the finished plasma bag is stabilized includes:
step S1, acquiring the current weight of the finished plasma bag as an initial weight value, and starting weight confirmation countdown with preset time duration;
the weighing device 20 receives the instruction of weighing that host computer 10 sent, then starts in order to weigh to the finished product bag of blood plasma, and the first weight value that the weighing device 20 weighed after starting is as initial weight value. Since the finished plasma bag is still connected to the plasma transfer bag, the amount of plasma in the finished plasma bag just weighed by the weighing device 20 may fluctuate, and therefore, whether the amount of plasma in the finished plasma bag reaches a steady state is determined by setting a time period within a range, and a weight determination countdown of a preset time period (for example, 2 seconds) is started.
Step S2, acquiring the weight of the finished plasma bag as a middle weight value every other first time interval during the weight confirmation countdown;
the weighing device 20 periodically, i.e., every first time period (e.g., 10 ms), acquires the weight weighed by the weighing device 20 during this weight confirmation countdown time, takes the weight as an intermediate weight value, and compares the intermediate weight value with the initial weight value each time to determine the amount of change in the weight of the finished plasma bag.
Step S3, if the difference between the intermediate weight value and the initial weight value exceeds the first threshold, re-executing step S1;
if the difference value between the intermediate weight value and the initial weight value (i.e. the weight change) exceeds a first threshold value (e.g. 1 g), i.e. the finished plasma bag increases or decreases beyond the first threshold value, determining that the weight of the current finished plasma bag is unstable, and restarting the weight confirmation countdown to confirm whether the plasma amount in the finished plasma bag is stable;
step S4, if the difference between each intermediate weight value and the initial weight value is less than or equal to the first threshold value during the weight confirmation countdown, locking the weight of the finished plasma bag to the initial weight value, and feeding back the initial weight value to the upper computer 10.
If the difference value between the intermediate weight value obtained each time and the initial weight value does not exceed the first threshold value in the weight confirmation countdown, the plasma volume in the finished plasma bag is confirmed to be stable, the weight of the finished plasma bag is maintained at the initial weight value, at this time, the weight of the finished plasma bag is locked as the initial weight value, and the initial weight value is sent to the upper computer 10.
Further, after receiving the initial weight value and completing sending the heat-sealing instruction to the heat-sealing device 30, if receiving the re-weighing request, the upper computer 10 sends a heat-sealing cancellation instruction to the heat-sealing device 30 and sends a weighing instruction to the weighing device 20, so that the weighing device 20 re-weighs the finished plasma bags.
After the upper computer 10 receives the initial weight value (i.e. the locked weight) fed back by the weighing device 20, it will send a heat sealing instruction to the heat sealing device 30, so that the heat sealing device 30 is ready to heat seal the inlet and outlet pipes of the finished plasma bags, and at the same time, the upper computer 10 will also display the received locked weight on the display device connected with the upper computer. Since it is necessary to make a standard content plasma product bag (e.g., the standard content plasma product bag is 200ml + -10%, 150ml + -10%, 100ml + -10%), when the operator finds that the weight displayed by the display device does not meet the requirement of the standard content plasma product bag, the operator needs to adjust the plasma amount in the current plasma finished product bag according to the content of the standard plasma finished product bag, the plasma finished product bag needs to be reweighed, the operator can send a reweighing request to the upper computer 10 through a physical key or a virtual key (for example, a reweighing key arranged on a touch screen), after the upper computer 10 receives the reweighing request, a heat seal cancellation instruction is sent to the heat seal device 30 to cause the heat seal device 30 to exit the heat seal operation state first, and resends the weighing instruction to the weighing device 20 to cause the weighing device 20 to re-weigh the current finished plasma bag.
In this embodiment, the regulation rule for the operator to adjust the plasma volume of the finished plasma bag is as follows: if the content of the current plasma finished product bag does not reach the previous standard, the plasma finished product bag is manufactured according to the next standard, and if the content of the current plasma finished product bag is only 170ml and does not reach 200ml +/-10%, an operator needs to extrude part of plasma in the plasma finished product bag back into the plasma transfer bag to manufacture the plasma finished product bag meeting the 150ml +/-10% standard so that the current plasma finished product bag meets the content requirement of the standard plasma finished product bag.
In addition, in other schemes, the upper computer 10 may also judge the locked weight fed back by the weighing device 20 by itself, that is: after receiving the initial weight value, the upper computer 10 determines the initial weight value to determine whether the initial weight value is within a weight value range corresponding to a preset standard content, that is, whether the weight value meets the requirement; if the initial weight value is within the weight value range corresponding to the preset standard content, the upper computer 10 does not interrupt the heat sealing process of the heat sealing device 30; if the initial weight value is not within the weight value range corresponding to the preset standard content, the upper computer 10 sends a heat sealing cancellation instruction to the heat sealing device 30, the heat sealing treatment of the heat sealing device 30 is interrupted, a weighing instruction is sent to the weighing device 20, and a prompt that the current locked weight of the plasma finished product bag is not satisfactory is sent, an operator adjusts the plasma volume of the plasma finished product bag according to the prompt, and the weighing device 20 reweighs the plasma finished product bag to determine the latest locked weight value. Wherein the standard row amount corresponds to a weight value range, for example, a standard content of 200ml + -10% corresponds to a weight range of 185g to 225g, a standard content of 150ml + -10% corresponds to a weight range of 139g to 169g, etc.
Referring to fig. 3, in the present embodiment, the weighing apparatus 20 includes a first processor 21(MCU), a first communication unit 22 and a first pressure sensor 23 electrically connected to the first processor 21, the first communication unit 22 is connected between the first processor 21 and the upper computer 10, and is used for information transmission between the first processor 21 and the upper computer 10, that is, for receiving/transmitting instructions and data between the first processor 21 and the upper computer 10; the first pressure sensor 23 is used for detecting the gravity of the finished plasma bag and feeding the detected gravity back to the first processor 21; the first processor 21 controls the first pressure sensor 23 to start up according to the weighing instruction sent by the upper computer 10 so as to detect the gravity of the finished plasma bag, and determines the weight of the finished plasma bag according to the gravity fed back by the first pressure sensor 23. The first communication unit 22 of the present embodiment is preferably an RS485 communication unit. Preferably, the weighing device 20 further comprises a nixie tube 24 (e.g. an LED nixie tube) and an indicator light 25, which are respectively electrically connected to the first processor 21, wherein the nixie tube 24 is used for displaying the weight of the finished plasma bag obtained by the first processor 21 according to the gravity detected by the first pressure sensor 23, and the indicator light 25 is used for displaying the weight locking state of the weighing device 20; for example, the indicator lamp 25 is on in the weight lock state, and the indicator lamp 25 is off in the non-weight lock state; or the indicator lamp 25 lights different colors in the weight-locked state and the non-weight-locked state, respectively.
Further, referring to fig. 4, in the present embodiment, the heat sealing apparatus 30 includes a second processor 31(MCU), and a second communication unit 32 (e.g., RS485 communication unit), a light-sensing detection unit 33 (e.g., light-sensing sensor), a heat sealing caliper 34, and a high-frequency board 35; the second communication unit 32 is used for information transmission between the second processor 31 and the upper computer 10; the light sensation detection unit 33 is used for detecting whether the inlet and outlet pipe of the plasma finished product bag is placed in the heat seal caliper 34; the high-frequency plate 35 is used for outputting power to the heat sealing caliper 34 to drive the heat sealing caliper 34 to carry out heat sealing on the inlet and outlet pipes of the plasma finished product bag, and the heat sealing principle is as follows: the inlet and outlet pipes are made of plastic materials, and under the action of a high-frequency electromagnetic field, molecules in the inlet and outlet pipes are polarized and mutually rubbed to generate heat, and the heat is fused and jointed. Referring to fig. 5, in this embodiment, the step of heat-sealing the inlet and outlet pipes of the plasma product bag by the heat-sealing device 30 includes:
1. after receiving a heat sealing instruction sent by the upper computer 10, the second processor 31 controls the light sensing detection unit 33 to start so as to detect whether an inlet pipe and an outlet pipe of a finished plasma bag are placed in the heat sealing calipers 34;
after the heat sealing device 30 receives the heat sealing instruction sent by the upper computer 10, the heat sealing device 30 is started, and the second processor 31 controls the light sensing detection unit 33 to work so as to detect whether the inlet and outlet pipe of the plasma finished product bag is placed in the heat sealing caliper 34.
2. After determining that the inlet and outlet tube of the plasma finished product bag is placed in the sealing caliper 34, the second processor 31 controls the high-frequency board 35 to start so as to drive the sealing caliper 34 to seal the inlet and outlet tube of the plasma finished product bag.
When the operator puts the inlet and outlet tube of the plasma finished product bag into the heat sealing caliper 34, the light sensing detection unit 33 generates a sensing signal and sends the sensing signal to the second processor 31, and the second processor 31 controls the high-frequency plate 35 to start and output a certain power to drive the heat sealing caliper 34 to heat seal the inlet and outlet tube of the plasma finished product bag.
Further, referring to fig. 4, the heat sealing apparatus 30 of the present embodiment further includes a current detecting unit 36, the current detecting unit 36 being electrically connected to the second processor 31 and the high frequency plate 35, respectively; the current detection unit 36 detects an input current of the high-frequency board 35 when the high-frequency board 35 operates, and feeds back the detected input current to the second processor 31; after receiving the input current fed back by the current detection unit 36, the second processor 31 calculates the input power of the high frequency board 35 according to the input current and analyzes whether the input power is within a preset normal power range; and when the input power of the high-frequency board 35 is not within the preset normal power range, the second processor 31 performs an abnormal alarm process. Because the heat sealing caliper 34 has too high or too low heat when the power output by the high-frequency plate 35 to the heat sealing caliper 34 is too large or too small, and the heat sealing effect on the inlet and outlet pipes of the plasma finished product bag is not good, the current detection unit 36 detects the input current of the high-frequency plate 35 in the embodiment, so that the second processor 31 can determine the input power of the high-frequency plate 35 according to the input current, the input power reflects the output power of the high-frequency plate 35, and further monitor whether the high-frequency plate 35 works normally; when the abnormal operation of the high-frequency plate 35 is monitored, an abnormal alarm (for example, a buzzer alarm or an alarm lamp alarm) is given, and an operator is prompted to perform maintenance treatment to ensure the heat sealing effect of the heat sealing device 30.
Further, referring to fig. 6, the virus inactivation monitor of the present embodiment further includes a scanning device 40 electrically connected to the upper computer 10, where the scanning device 40 is configured to scan the marking information of the plasma finished product bag and the marking of the operator, and feed the scanning information back to the upper computer 10, and the upper computer 10 stores the received scanning information. Wherein, the marking information of the plasma finished product bag comprises the blood batch and quantity, the name of the blood component and the like. In addition, the upper computer 10 also stores the weighing information and the heat seal information; wherein the weighing information comprises weighing time (time when each plasma finished product bag is weighed), information of a weighing person, weight of the plasma finished product bag, and using times of the weighing device 20 (according to the number of the plasma finished product bags); the heat sealing information comprises heat sealing time (time when each bag of plasma is subjected to heat sealing to form a bag), heat sealing duration and heat sealing times (one bag of plasma finished product bag is subjected to heat sealing for several times, normally, one bag of plasma finished product bag is subjected to heat sealing once, machine faults or human factors are avoided, secondary heat sealing is performed when the first heat sealing is unsuccessful, and the heat sealing times are recorded so that the operation becomes traceability.
Further, referring to fig. 7, in the present embodiment, the bracket filtering apparatus includes a top weighing plate (not shown), on which a second pressure sensor 50 and a plurality of hooks (not shown) for hanging the original plasma bag are disposed, and the hooks are connected to the second pressure sensor 50; the second pressure sensor 50 is electrically connected with the upper computer 10 and is used for detecting the total gravity of the blood bag hung on the top weighing plate and feeding the detected gravity back to the upper computer 10;
in the plasma virus inactivation and filtration treatment, the upper computer 10 controls the second pressure sensor 50 to detect the total gravity of the blood bag suspended on the top weighing plate at regular time (for example, every 10 seconds), and analyzes whether the difference of the total gravity of two adjacent times detected by the second pressure sensor 50 is within a preset first difference range (for example, 7g to 9 g); if the difference of the total gravity exceeds the first difference range, the upper computer 10 determines that the filtration of the blood plasma is abnormal, and performs filtration abnormity alarm. Since the filter is normally stable in the passage speed of plasma without a large difference, the amount of plasma passing through the filter is normally stable within a range for a fixed time, and when the filter is abnormal, the amount of plasma passing through the filter may become large or small beyond the stable range in the normal case for a fixed time. Therefore, in the present embodiment, the second pressure sensor 50 is controlled to detect the total weight of the blood bag suspended on the top bearing plate at regular time, so as to obtain the difference between the total weight of two adjacent blood bags detected by the second pressure sensor 50, and by analyzing whether the difference of the total weight exceeds the preset first difference range, it can be determined whether the filter is abnormal; if not, the filter is normal; if the blood plasma exceeds the preset value, the filter is abnormal, and the upper computer 10 controls to send out a filtering abnormity alarm (such as a buzzer alarm) to remind an operator of processing the filter, such as detection, maintenance and the like, so as to ensure that the blood plasma is filtered normally and reliably.
Further, the present embodiment also adopts a scheme of further checking whether filtering is abnormal: the upper computer 10 further determines the weight reduction amount of the blood bag suspended on the top weighing plate in the plasma filtration process according to the gravity fed back by the second pressure sensor 50 after the weighing device 20 locks the weight, wherein the weight reduction amount is obtained by subtracting the weight determined by the gravity fed back by the second pressure sensor 50 at the moment when the upper computer 10 locks the weight from the weight determined by the gravity fed back by the second pressure sensor 50 at the moment when the current plasma finished product bag is manufactured; the upper computer 10 analyzes whether the difference between the weight reduction amount and the weight of the finished plasma bag locked by the weighing device 20 is within a preset second difference range (for example, less than 5 g); if the filtering is normal, the difference value is within the second difference value range; if the difference exceeds the second difference range, the upper computer 10 determines that the filtering of the plasma is abnormal, and performs abnormal filtering alarm to remind an operator of processing the filter such as detection and maintenance, so as to ensure that the filtering of the plasma is normal and reliable.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the contents of the present specification and the accompanying drawings, or directly/indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (7)
1. The virus inactivation monitor is characterized by comprising a machine body, and an upper computer, a filtering bracket device, a weighing device and a heat sealing device which are arranged on the machine body, wherein the filtering bracket device is used for suspending and supporting a blood bag in the plasma virus inactivation and filtration treatment; the upper computer is electrically connected with the weighing device and the heat sealing device, and the weighing device is used for weighing the finished plasma bags according to a weighing instruction sent by the upper computer and locking the weighed weight after the weight of the finished plasma bags is stable; the upper computer sends a heat sealing instruction to the heat sealing device after the weighing device locks the weight of the plasma finished product bag, so that the heat sealing device carries out heat sealing on an inlet pipe and an outlet pipe of the plasma finished product bag; the upper computer controls the weighing device to release weight locking after the heat sealing device finishes the heat sealing of the inlet and outlet pipes of the plasma finished product bag so as to weigh the next plasma finished product bag;
the weighing device weighs the finished plasma bag according to the weighing instruction that the host computer sent to the step that the weight that the locking was weighed and was obtained after the weight of finished plasma bag is stable includes:
s1, acquiring the current weight of the finished plasma bag as an initial weight value, and starting weight confirmation countdown with preset time duration;
s2, acquiring the weight of the finished plasma product bag as a middle weight value every other first time interval in the weight confirmation countdown;
s3, if the difference value between the intermediate weight value and the initial weight value exceeds a first threshold value, re-executing the step S1;
s4, if the difference value between each intermediate weight value and the initial weight value is less than or equal to the first threshold value in the weight confirmation countdown, locking the weight of the finished plasma bag as the initial weight value, and feeding back the initial weight value to the upper computer;
the filtering support device comprises a top weighing plate, a second pressure sensor and a plurality of hooks for hanging the original plasma bag are arranged on the top weighing plate, and the hooks are connected with the second pressure sensor; the second pressure sensor is electrically connected with an upper computer and is used for detecting the total gravity of the blood bag hung on the top weighing plate and feeding the detected gravity back to the upper computer;
in the plasma virus inactivation and filtration treatment, the upper computer controls the second pressure sensor to detect the total gravity of the blood bag suspended on the top weighing plate at regular time, and analyzes whether the difference value of the total gravity of two adjacent times detected by the second pressure sensor is within a preset first difference value range; if the difference value of the total gravity exceeds the first difference value range, the upper computer determines that the filtration of the plasma is abnormal, and carries out filtration abnormity alarm;
the upper computer also determines the weight reduction amount of the blood bag suspended on the top weighing plate in the plasma filtering process according to the gravity fed back by the second pressure sensor after the weighing device locks the weight, and analyzes whether the difference value between the weight reduction amount and the weight of the finished plasma bag locked by the weighing device is within a preset second difference value range; and if the difference exceeds the second difference range, the upper computer determines that the filtration of the plasma is abnormal and carries out filtration abnormity alarm.
2. The virus inactivation monitor of claim 1, wherein the host computer sends a heat seal cancellation command to the heat sealing device and sends a weighing command to the weighing device after receiving the initial weight value and completing sending a heat seal command to the heat sealing device, and the weighing device reweighs the finished plasma bags if receiving a reweighing request.
3. The virus inactivation monitor of claim 1, wherein the weighing device comprises a first processor, a first communication unit, and a first pressure sensor electrically connected to the first processor, the first communication unit being connected between the first processor and the upper computer for transmitting information between the first processor and the upper computer; the first pressure sensor is used for detecting the gravity of the finished plasma bag and feeding the detected gravity back to the first processor; the first processor controls the first pressure sensor to start to detect the gravity of the finished plasma product bag according to the weighing instruction sent by the upper computer, and determines the weight of the finished plasma product bag according to the gravity fed back by the first pressure sensor.
4. The virus inactivation monitor of claim 3, wherein the weighing device further comprises a nixie tube and an indicator light electrically connected to the first processor, respectively, the nixie tube being configured to display a weight of the finished plasma bag derived by the first processor based on gravity detected by the first pressure sensor, the indicator light being configured to display a weight lock status of the weighing device.
5. The virus inactivation monitor of claim 1, wherein the heat sealing means comprises a second processor and a second communication unit, a light sensing detection unit, a heat sealing caliper and a high frequency plate electrically connected to the second processor, respectively; the second communication unit is used for information transmission between the second processor and the upper computer; the light sensation detection unit is used for detecting whether an inlet pipe and an outlet pipe of the finished plasma bag are placed in the heat seal caliper or not; the high-frequency plate is used for outputting power to the heat sealing calipers so as to drive the heat sealing calipers to heat seal the inlet and outlet pipes of the plasma finished product bag;
the step of heat-sealing the inlet and outlet pipes of the plasma finished product bag by the heat-sealing device comprises the following steps:
after receiving a heat sealing instruction sent by an upper computer, the second processor controls the light sensation detection unit to start so as to detect whether an inlet pipe and an outlet pipe of a finished plasma bag are placed in the heat sealing calipers or not;
and after the inlet and outlet pipe of the plasma finished product bag is determined to be placed into the heat sealing calipers, the second processor controls the high-frequency plate to be started so as to drive the heat sealing calipers to carry out heat sealing on the inlet and outlet pipe of the plasma finished product bag.
6. The virus inactivation monitor of claim 5, wherein the heat sealing apparatus further comprises a current detection unit electrically connected to the second processor and the high frequency board, respectively; the current detection unit detects the input current of the high-frequency plate when the high-frequency plate works, and feeds the detected input current back to the second processor; after receiving the input current fed back by the current detection unit, the second processor calculates the input power of the high-frequency board according to the input current and analyzes whether the input power is within a preset normal power range; and when the input power of the high-frequency board is not within the preset normal power range obtained through analysis, the second processor performs exception alarm processing.
7. The virus inactivation monitor of claim 1, wherein the body is further provided with a scanning device electrically connected to the upper computer, the scanning device is configured to scan the marking information of the finished plasma bags and the markings of the operator, and feed the scanning information back to the upper computer, and the upper computer stores the received scanning information.
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