CN108434381A - A kind of Chinese medicine and preparation method thereof for treating Low Back Pain kidney deficiency - Google Patents
A kind of Chinese medicine and preparation method thereof for treating Low Back Pain kidney deficiency Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/14—Antitussive agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P39/06—Free radical scavengers or antioxidants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Abstract
The invention discloses the Chinese medicine and preparation method thereof for the treatment of Low Back Pain kidney deficiency, the Chinese medicine of the treatment Low Back Pain kidney deficiency includes according to the raw material of parts by weight：Cortex Eucommiae, Stauntonia latifolia, aleppo dock rhizome, pig kidney, crinite uraria root, CORTEX PHELLODENDRI CHINENSE, fructus alpiniae oxyphyllae, Chinese chestnut kernel.Drug effect of the present invention is rapid, curative effect is high, with promotion hematopoiesis, improve immune function, the multiple pharmacological effects such as anti anoxia, anti-infective, there is good curative effect each component to meet pharmaceutical control and administration law regulation the illnesss such as cough due to deficiency of the lung, kidney deficiency, seminal emission, leukorrhea, arthralgia pain due to rheumatism, soreness of waist and knee joint, fatigue, hindered again using the comprehensive function treatment of each taste Chinese medicine, no chemical analysis is non-toxic to humans.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, the Chinese medicine and preparation method thereof of specifically a kind for the treatment of Low Back Pain kidney deficiency.
Background technology
Kidney deficiency refers to that kidney vital essence negative and positive are insufficient, divides kidney-yin deficiency and kidney-yang deficiency.The symptom of kidney deficiency shows in terms of sexual function
It is reduced for sexual function：Man's property interest reduces, and sexual desire reduces, and impotence or penis are lifted without heavily fortified point, seminal emission, involuntary emission, premature ejaculation, microscope
Check that visible oligozoospermia or motility of sperm lower, infertility；Woman's hypoplasia of uterus, as hypoplasia of uterus, premature ovarian failure close
Through, irregular menstruation, sexual hypoesthesia is infertile etc..
With the development of society, infertile incidence is higher and higher, the infertile incidence in the whole world at present according to statistics
It is 15% or so.The infertility caused by male factor is known as male sterility.Research confirms male sterility mainly and sperm motility
Ability is related.The male sterility caused by " low sperm activity disease " occurred when sperm function exception is roughly equivalent to Chinese medicine
The cards such as " essence is weak ", " cold sperm ", " essence is cold ".《Synopsis Golden Chamber》Cloud：" pulse of a man being floating,weak and hesitant is that s.m.p vital essence is cold ",《After all pathogenies
By》Cloud " husband s.m.p person, seminal plasma such as water, cold such as ice iron, is all the time of s.m.p ",《The secret record in stone room》Cloud：" the not raw son of man,
Have six because an essence is cold, a laboured breathing ... ", ZHU Dan-xi《Danxi's experiential therapy》There is meaning " having smart empty essence is weak cannot be at tire person ".Essence
Then essence mistake is warm for cold, cold sperm, and no sun is then motionless, causes sperm debility or mobility to lower, so as to cause difficulty of becoming pregnant.
Qi and blood metaplasia only has qi and blood not lose in taste, essence and blood metaplasia in liver kidney, human body, and essence and blood is lossless, and spirit could be abundant.
The kidney being the origin of congenital constitution, and viscus attributed to water and fire, vigour is gathered.The insufficiency of the kidney yang, the Yang-function insufficiency of kidneyzang cannot be warm, very the then fire not raw-soil, influences spleen
The receiving and transporting of stomach, therefore laboured breathing god is tired, soreness and weakness of waist and knees or diet are reduced；Kidney storing essence, deficiency of yang fire decline, failure to store, and essence is closed not
Gu or kidney deficiency cannot be taken the photograph admittedly, therefore impotence and seminal emission, not breed long.《New eight gusts of the side of Jing Yue's complete work》Say that " kind yang-tonifying person, must be in the moon
In seek sun, then it is positive it is cloudy help, and it is biochemical infinite." the kidney generating marrow and dominating bone, marrow green blood, kidney qi contains then marrow and fills that bone is strong, and blood obtains source of students.Therefore
Control suitable warming kidney and enhancing yang, reinforce the kidney beneficial essence, nourishing qi and blood, tonifying both YIN and YANG.
According to China's Traditional Chinese medical theory and modern molecular study of pharmacy, for the pathogenesis of kidney deficiency, by that will mend
Kidney controlling nocturnal emission with astringent drugs, nourishing the liver invigorating the spleen Chinese medicine carry out rational compatibility extraction, to achieve the purpose that improvement and treatment deficiency of the kidney.
Invention content
The purpose of the present invention is to provide a kind of curative effect height, the Chinese medicine for the treatment Low Back Pain kidney deficiency having no toxic side effect and its preparations
Method, to solve the problems mentioned in the above background technology.
To achieve the above object, the present invention provides the following technical solutions：
A kind of Chinese medicine for treating Low Back Pain kidney deficiency includes according to the raw material of parts by weight：5 ~ 20 parts of Cortex Eucommiae, 5 ~ 40 parts of Stauntonia latifolia, blood are worked as
Return 5 ~ 20 parts, 60 ~ 80 parts of pig kidney.
Further, in parts by weight, which further includes：8 ~ 10 parts of crinite uraria root, 8 ~ 10 parts of CORTEX PHELLODENDRI CHINENSE, fructus alpiniae oxyphyllae
8 ~ 10 parts, 8 ~ 10 parts of Chinese chestnut kernel.
The preparation method of the Chinese medicine for the treatment of Low Back Pain kidney deficiency of the present invention, which is characterized in that be as follows：
（1）Each raw material is weighed according to parts by weight；
（2）Cortex Eucommiae, Stauntonia latifolia, aleppo dock rhizome, crinite uraria root, CORTEX PHELLODENDRI CHINENSE, fructus alpiniae oxyphyllae, Chinese chestnut kernel are mixed, crushed as 60 ~ 80 mesh
Powder, 3 ~ 5 times of ultra-pure water of powder and its quality is mixed, 2 ~ 3h is impregnated at 45 ~ 55 DEG C, adds soaking solution quality
5 ~ 8% complex enzyme digests 3 ~ 5h, stirs 10 ~ 20min per hour, is concentrated under reduced pressure through ultrafiltration membrane, make its water content be down to 40 ~
50%, it is spare to obtain concentrate；
（3）Pig kidney is splitted along side line from centre, but cannot it is completely separable into two, reject muscle, clean, the pig that will be handled well
Kidney is placed into 0 ~ 4 DEG C of refrigerator, after refrigerating 15-25min, temperature is reduced to -25 ~ -35 DEG C, keeps the temperature 40-60min,
Temperature is risen into room temperature again；
（4）Concentrate obtained by previous step is placed into pig kidney, makes pig kidney cut closure with filament binding, in Pigs Kidney
Sublist bread wraps up in one layer of preservative film, is put into steamer and steams 60-80min, and preservative film, filament are removed after temperature is down to room temperature, is gone
Except the dregs of a decoction, pig kidney is eaten.
Further, the step（2）Middle complex enzyme is 1 by mass ratio:1 cellulase and pectase mixes.
Further, the step（2）Middle stir speed (S.S.) is 60-90r/min.
Further, the step（2）Described in the pressure that is concentrated under reduced pressure be 0.3-0.5 standard atmospheric pressure.
Further, the step（3）Described in temperature reducing rate be 0.5-0.8 DEG C/min.
Further, the step（4）The pressure of middle steamer is 1.1-1.5 standard atmospheric pressure.
Compared with prior art, the beneficial effects of the invention are as follows：
Drug ratio science of the present invention, drug effect absorptivity is high after being made through the present invention, works rapid, drug of the invention has
Promote hematopoiesis, improves immune function, anti anoxia, anti-infective, the multiple pharmacological effects such as promotion ammonia tomb acid metabolic, for deficiency syndrome of the lung cough
Cough, kidney deficiency, seminal emission, leukorrhea, arthralgia pain due to rheumatism, soreness of waist and knee joint, the illnesss such as fatigue have good curative effect, it is original to select animal and plant medicine
Material, each component meet pharmaceutical control and administration law regulation, are hindered again using the comprehensive function treatment of each taste Chinese medicine, no chemical analysis is nontoxic to human body
It is harmless.
Specific implementation mode
The technical solution of this patent is described in more detail With reference to embodiment.
Embodiment 1
A kind of Chinese medicine for treating Low Back Pain kidney deficiency includes according to the raw material of parts by weight：5 parts of Cortex Eucommiae, 5 parts of Stauntonia latifolia, 5 parts of aleppo dock rhizome,
60 parts of pig kidney, 8 parts of crinite uraria root, 8 parts of CORTEX PHELLODENDRI CHINENSE, 8 parts of fructus alpiniae oxyphyllae, 8 parts of Chinese chestnut kernel.
The preparation method of the Chinese medicine for the treatment of Low Back Pain kidney deficiency of the present invention, which is characterized in that be as follows：
（1）Each raw material is weighed according to parts by weight；
（2）Cortex Eucommiae, Stauntonia latifolia, aleppo dock rhizome, crinite uraria root, CORTEX PHELLODENDRI CHINENSE, fructus alpiniae oxyphyllae, Chinese chestnut kernel are mixed, crushed as 60 purposes
3 times of ultra-pure water of powder and its quality is mixed, impregnates 2h at 45 DEG C, add the compound of soaking solution quality 5% by powder
Enzyme, complex enzyme are 1 by mass ratio:1 cellulase and pectase mixes, and digests 3h, stirs 10min per hour, stirs
Rate is 60r/min, is concentrated under reduced pressure through ultrafiltration membrane in 0.3 normal atmosphere pressure, so that its water content is down to 40%, obtain concentrate
It is spare；
（3）Pig kidney is splitted along side line from centre, but cannot it is completely separable into two, reject muscle, clean, the pig that will be handled well
Kidney is placed into 0 DEG C of refrigerator, and after refrigerating 15min, refrigerated storage temperature is reduced to -25 with the cooling rate of 0.5 DEG C/min
DEG C, 40min is kept the temperature, then temperature is risen into room temperature；
（4）Concentrate obtained by previous step is placed into pig kidney, makes pig kidney cut closure with filament binding, in Pigs Kidney
Sublist bread wraps up in one layer of preservative film, is put into steamer and steams 60min, and steamer air pressure is that 1.1 standard atmospheric pressures wait for that temperature is down to often
Preservative film, filament are removed after temperature, removes the dregs of a decoction, eat pig kidney.
Embodiment 2
A kind of Chinese medicine for treating Low Back Pain kidney deficiency includes according to the raw material of parts by weight：20 parts of Cortex Eucommiae, 40 parts of Stauntonia latifolia, aleppo dock rhizome 20
Part, 80 parts of pig kidney, 10 parts of crinite uraria root, 10 parts of CORTEX PHELLODENDRI CHINENSE, 10 parts of fructus alpiniae oxyphyllae, 10 parts of Chinese chestnut kernel.
The preparation method of the Chinese medicine for the treatment of Low Back Pain kidney deficiency of the present invention, which is characterized in that be as follows：
（1）Each raw material is weighed according to parts by weight；
（2）Cortex Eucommiae, Stauntonia latifolia, aleppo dock rhizome, crinite uraria root, CORTEX PHELLODENDRI CHINENSE, fructus alpiniae oxyphyllae, Chinese chestnut kernel are mixed, crushed as 80 purposes
5 times of ultra-pure water of powder and its quality is mixed, impregnates 3h at 55 DEG C, add the compound of soaking solution quality 8% by powder
Enzyme, complex enzyme are 1 by mass ratio:1 cellulase and pectase mixes, and digests 5h, stirs 20min per hour, stirs
Rate is 90r/min, is concentrated under reduced pressure through ultrafiltration membrane in 0.5 normal atmosphere pressure, so that its water content is down to 50%, obtain concentrate
It is spare；
（3）Pig kidney is splitted along side line from centre, but cannot it is completely separable into two, reject muscle, clean, the pig that will be handled well
Kidney is placed into 4 DEG C of refrigerator, and after refrigerating 25min, refrigerated storage temperature is reduced to -35 with the cooling rate of 0.8 DEG C/min
DEG C, 60min is kept the temperature, then temperature is risen into room temperature；
（4）Concentrate obtained by previous step is placed into pig kidney, makes pig kidney cut closure with filament binding, in Pigs Kidney
Sublist bread wraps up in one layer of preservative film, is put into steamer and steams 80min, and steamer air pressure is that 1.5 standard atmospheric pressures wait for that temperature is down to often
Preservative film, filament are removed after temperature, removes the dregs of a decoction, eat pig kidney.
Embodiment 3
A kind of Chinese medicine for treating Low Back Pain kidney deficiency includes according to the raw material of parts by weight：11 parts of Cortex Eucommiae, 22 parts of Stauntonia latifolia, aleppo dock rhizome 11
Part, 77 parts of pig kidney, 9 parts of crinite uraria root, 9 parts of CORTEX PHELLODENDRI CHINENSE, 9 parts of fructus alpiniae oxyphyllae, 9 parts of Chinese chestnut kernel.
The preparation method of the Chinese medicine for the treatment of Low Back Pain kidney deficiency of the present invention, which is characterized in that be as follows：
（1）Each raw material is weighed according to parts by weight；
（2）Cortex Eucommiae, Stauntonia latifolia, aleppo dock rhizome, crinite uraria root, CORTEX PHELLODENDRI CHINENSE, fructus alpiniae oxyphyllae, Chinese chestnut kernel are mixed, crushed as 70 purposes
4 times of ultra-pure water of powder and its quality is mixed, impregnates 2.5h at 50 DEG C, add answering for soaking solution quality 7% by powder
Synthase, complex enzyme are 1 by mass ratio:1 cellulase and pectase mixes, and digests 4h, stirs 15min per hour, stir
It is 88r/min to mix rate, is concentrated under reduced pressure through ultrafiltration membrane in 0.4 normal atmosphere pressure, so that its water content is down to 45%, must concentrate
Object is spare；
（3）Pig kidney is splitted along side line from centre, but cannot it is completely separable into two, reject muscle, clean, the pig that will be handled well
Kidney is placed into 3 DEG C of refrigerator, and after refrigerating 22min, refrigerated storage temperature is reduced to -29 with the cooling rate of 0.6 DEG C/min
DEG C, 50min is kept the temperature, then temperature is risen into room temperature；
（4）Concentrate obtained by previous step is placed into pig kidney, makes pig kidney cut closure with filament binding, in Pigs Kidney
Sublist bread wraps up in one layer of preservative film, is put into steamer and steams 70min, and steamer air pressure is that 1.4 standard atmospheric pressures wait for that temperature is down to often
Preservative film, filament are removed after temperature, removes the dregs of a decoction, eat pig kidney.
Embodiment 4
A kind of Chinese medicine for treating Low Back Pain kidney deficiency includes according to the raw material of parts by weight：8 parts of Cortex Eucommiae, 6 parts of Stauntonia latifolia, 7 parts of aleppo dock rhizome,
80 parts of pig kidney, 10 parts of crinite uraria root, 8 parts of CORTEX PHELLODENDRI CHINENSE, 8 parts of fructus alpiniae oxyphyllae, 8 parts of Chinese chestnut kernel.
The preparation method of the Chinese medicine for the treatment of Low Back Pain kidney deficiency of the present invention, which is characterized in that be as follows：
（1）Each raw material is weighed according to parts by weight；
（2）Cortex Eucommiae, Stauntonia latifolia, aleppo dock rhizome, crinite uraria root, CORTEX PHELLODENDRI CHINENSE, fructus alpiniae oxyphyllae, Chinese chestnut kernel are mixed, crushed as 60 purposes
3 times of ultra-pure water of powder and its quality is mixed, impregnates 3h at 55 DEG C, add the compound of soaking solution quality 8% by powder
Enzyme, complex enzyme are 1 by mass ratio:1 cellulase and pectase mixes, and digests 5h, stirs 10min per hour, stirs
Rate is 60r/min, is concentrated under reduced pressure through ultrafiltration membrane in 0.3 normal atmosphere pressure, so that its water content is down to 40%, obtain concentrate
It is spare；
（3）Pig kidney is splitted along side line from centre, but cannot it is completely separable into two, reject muscle, clean, the pig that will be handled well
Kidney is placed into 0 DEG C of refrigerator, and after refrigerating 15min, refrigerated storage temperature is reduced to -25 with the cooling rate of 0.5 DEG C/min
DEG C, 40min is kept the temperature, then temperature is risen into room temperature；
（4）Concentrate obtained by previous step is placed into pig kidney, makes pig kidney cut closure with filament binding, in Pigs Kidney
Sublist bread wraps up in one layer of preservative film, is put into steamer and steams 60min, and steamer air pressure is that 1.1 standard atmospheric pressures wait for that temperature is down to often
Preservative film, filament are removed after temperature, removes the dregs of a decoction, eat pig kidney..
Embodiment 5
A kind of Chinese medicine for treating Low Back Pain kidney deficiency includes according to the raw material of parts by weight：14 parts of Cortex Eucommiae, 15 parts of Stauntonia latifolia, aleppo dock rhizome 10
Part, 70 parts of pig kidney, 8 parts of crinite uraria root, 10 parts of CORTEX PHELLODENDRI CHINENSE, 10 parts of fructus alpiniae oxyphyllae, 10 parts of Chinese chestnut kernel.
The preparation method of the Chinese medicine for the treatment of Low Back Pain kidney deficiency of the present invention, which is characterized in that be as follows：
（1）Each raw material is weighed according to parts by weight；
（2）Cortex Eucommiae, Stauntonia latifolia, aleppo dock rhizome, crinite uraria root, CORTEX PHELLODENDRI CHINENSE, fructus alpiniae oxyphyllae, Chinese chestnut kernel are mixed, crushed as 80 purposes
5 times of ultra-pure water of powder and its quality is mixed, impregnates 2h at 55 DEG C, add the compound of soaking solution quality 5% by powder
Enzyme, complex enzyme are 1 by mass ratio:1 cellulase and pectase mixes, and digests 3h, stirs 10min per hour, stirs
Rate is 60r/min, is concentrated under reduced pressure through ultrafiltration membrane in 0.3 normal atmosphere pressure, so that its water content is down to 40%, obtain concentrate
It is spare；
（3）Pig kidney is splitted along side line from centre, but cannot it is completely separable into two, reject muscle, clean, the pig that will be handled well
Kidney is placed into 0 DEG C of refrigerator, and after refrigerating 15min, refrigerated storage temperature is reduced to -25 with the cooling rate of 0.5 DEG C/min
DEG C, 40min is kept the temperature, then temperature is risen into room temperature；
（4）Concentrate obtained by previous step is placed into pig kidney, makes pig kidney cut closure with filament binding, in Pigs Kidney
Sublist bread wraps up in one layer of preservative film, is put into steamer and steams 80min, and steamer air pressure is that 1.5 standard atmospheric pressures wait for that temperature is down to often
Preservative film, filament are removed after temperature, removes the dregs of a decoction, eat pig kidney.
Test example
1, mouse dose of the invention experiment and kidney deficiency model testing
KM kinds mouse 60 is selected, growth health, weight is 42.3 ± 0.56g, is selecting 20 mouse subcutaneous injections at random
Hydrocortisone 15mg/kg weight, only, intracerebroventricular injection detects mouse to 20 days rear side intracerebroventricular AB zs-6Hg/ after 20 days,
There is deficiency of the kidney.
It is 5g/kg that the present invention, which recommends dosage,；20 mouse doses of drug are not injected in dosage setting according to the invention,
Its dosage multiple is 1 times, 10 times, 50 times, and drug of the present invention is added to feeding in feed, and mouse growth shape is observed after one month
Condition, and 8 mouse dissections are selected at random, check its lesion tissue situation, test result：Take the mouse health of drug of the present invention
In order, do not occur exception.
The feeding drug of the present invention in 20 mouse chows of the injection drug in kidney deficiency model, twice daily, each dosage
Recommend dosage identical with the present invention, feeding observes its sign situation after 3 weeks, in addition 20 kidney deficiency model mices synchronize raising, make
For reference, mouse is dissected, compares the variation of its index, test result：The universal activity of mouse for taking drug of the present invention is fast, does not take
It is dispirited with the model mice state of drug, internal organ variation such as table：
| Drug administration mouse | Non- drug administration mouse | |
| Spleen weight（mg） | 71.48 | 109.45 |
| Chest gland weight（mg） | 21.36 | 39.87 |
It can be seen that drug of the present invention is apparent for mice spleen weight, chest gland weight reducing effect, improve the significant effect that immune indexes decline,
For inhibiting mouse condition worse to bring positive effect, effective percentage 100%.
2, clinical test of the invention：
It being diagnosed as from hospital in the patient of kidney deficiency and picks totally 164 progress clinical observations, wherein the range of age is 25 ~ 75 years old,
Wherein, 25 ~ 45 years old 68 people, 46 ~ 65 years old 42 people, 66 ~ 75 years old 54 people, male 84, women 80, the course of disease are 3 months~15 years.
Two times a day, 3 weeks it is as a treatment course, treat 3 courses for the treatment of altogether, the specific symptom of patient be soreness and weakness of waist and knees or talagia, alopecia or
Tooth mobility, tinnitus or deafness, urine retention or the urinary incontinence.Avoid cold and uncooked food during treatment pungent irritable food.
Criterion of therapeutical effect：Recovery from illness, symptom completely disappear, without repeatedly after being discontinued 3 months；Effective, symptom is obviously eased；Have
Effect, symptom are mitigated, but occasional aggravates；In vain:Symptom is without alleviating or have exacerbation trend；Recurrence tracks 5 after confirming recovery from illness
A month, symptom did not occurred.
| It cures | It is effective | Effectively | In vain | Recurrence | Cure rate | Total effective rate |
| 132 | 18 | 12 | 2 | 0 | 80.5% | 98.7% |
The cure rate of the present invention reaches 80.5% it can be seen from table, total effective rate 98.7%, therapeutic effect is notable.
The better embodiment of this patent is explained in detail above, but this patent is not limited to above-mentioned embodiment party
Formula, one skilled in the relevant art within the scope of knowledge, can also be under the premise of not departing from this patent objective
Various changes can be made.
Claims (8)
1. a kind of Chinese medicine for treating Low Back Pain kidney deficiency, which is characterized in that include according to the raw material of parts by weight：5 ~ 20 parts of Cortex Eucommiae, August
5 ~ 40 parts of melon, 5 ~ 20 parts of aleppo dock rhizome, 60 ~ 80 parts of pig kidney.
2. the Chinese medicine for the treatment of Low Back Pain kidney deficiency according to claim 1, which is characterized in that in parts by weight, the raw material is also
Including：8 ~ 10 parts of crinite uraria root, 8 ~ 10 parts of CORTEX PHELLODENDRI CHINENSE, 8 ~ 10 parts of fructus alpiniae oxyphyllae, 8 ~ 10 parts of Chinese chestnut kernel.
3. a kind of preparation method of the Chinese medicine for the treatment of Low Back Pain kidney deficiency as described in claim 1 ~ 2 is any, which is characterized in that specific
Steps are as follows：
（1）Each raw material is weighed according to parts by weight；
（2）Cortex Eucommiae, Stauntonia latifolia, aleppo dock rhizome, crinite uraria root, CORTEX PHELLODENDRI CHINENSE, fructus alpiniae oxyphyllae, Chinese chestnut kernel are mixed, crushed as 60 ~ 80 mesh
Powder, 3 ~ 5 times of ultra-pure water of powder and its quality is mixed, 2 ~ 3h is impregnated at 45 ~ 55 DEG C, adds soaking solution quality
5 ~ 8% complex enzyme digests 3 ~ 5h, stirs 10 ~ 20min per hour, is concentrated under reduced pressure through ultrafiltration membrane, make its water content be down to 40 ~
50%, it is spare to obtain concentrate；
（3）Pig kidney is splitted along side line from centre, but cannot it is completely separable into two, reject muscle, clean, the pig that will be handled well
Kidney is placed into 0 ~ 4 DEG C of refrigerator, after refrigerating 15-25min, temperature is reduced to -25 ~ -35 DEG C, keeps the temperature 40-60min,
Temperature is risen into room temperature again；
（4）Concentrate obtained by previous step is placed into pig kidney, makes pig kidney cut closure with filament binding, in Pigs Kidney
Sublist bread wraps up in one layer of preservative film, is put into steamer and steams 60-80min, and preservative film, filament are removed i.e. after temperature is down to room temperature
Can, the dregs of a decoction are removed, pig kidney is eaten.
4. the preparation method of the Chinese medicine for the treatment of Low Back Pain kidney deficiency as claimed in claim 3, which is characterized in that the step（2）In
Complex enzyme is 1 by mass ratio:1 cellulase and pectase mixes.
5. the preparation method of the Chinese medicine for the treatment of Low Back Pain kidney deficiency as claimed in claim 3, which is characterized in that the step（2）In
Stir speed (S.S.) is 60-90r/min.
6. the preparation method of the Chinese medicine for the treatment of Low Back Pain kidney deficiency as claimed in claim 3, which is characterized in that the step（2）In
The pressure of the reduced pressure is 0.3-0.5 standard atmospheric pressure.
7. the preparation method of the Chinese medicine for the treatment of Low Back Pain kidney deficiency as claimed in claim 3, which is characterized in that the step（3）In
The temperature reducing rate is 0.5-0.8 DEG C/min.
8. the preparation method of the Chinese medicine for the treatment of Low Back Pain kidney deficiency as claimed in claim 3, which is characterized in that the step（4）In
The pressure of steamer is 1.1-1.5 standard atmospheric pressure.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462701A (en) * | 2010-11-08 | 2012-05-23 | 中国中医科学院西苑医院 | Enzyme method for refining Chinese medicine extract |
| CN103505712A (en) * | 2013-09-30 | 2014-01-15 | 周复礼 | Medicine for treating lumbago due to kidney-asthenia and preparation method thereof |
| CN107261049A (en) * | 2017-06-22 | 2017-10-20 | 合肥诚君信息科技有限公司 | A kind of Chinese medicine for treating kidney deficiency |
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2018
- 2018-05-14 CN CN201810454112.2A patent/CN108434381A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462701A (en) * | 2010-11-08 | 2012-05-23 | 中国中医科学院西苑医院 | Enzyme method for refining Chinese medicine extract |
| CN103505712A (en) * | 2013-09-30 | 2014-01-15 | 周复礼 | Medicine for treating lumbago due to kidney-asthenia and preparation method thereof |
| CN107261049A (en) * | 2017-06-22 | 2017-10-20 | 合肥诚君信息科技有限公司 | A kind of Chinese medicine for treating kidney deficiency |
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