CN108420855A - A kind of pharmaceutical composition of prevention dysmenorrhoea - Google Patents
A kind of pharmaceutical composition of prevention dysmenorrhoea Download PDFInfo
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- CN108420855A CN108420855A CN201810573954.XA CN201810573954A CN108420855A CN 108420855 A CN108420855 A CN 108420855A CN 201810573954 A CN201810573954 A CN 201810573954A CN 108420855 A CN108420855 A CN 108420855A
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- rhizoma
- angelicae sinensis
- extract
- radix angelicae
- corydalis tuber
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
The invention discloses a kind of pharmaceutical compositions of prevention dysmenorrhoea, the composition is using the extract of Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis and corydalis tuber as active ingredient, it is collectively constituted with receptible auxiliary adding ingredient in drug, the parts by weight of the ratio of the extract of Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis and corydalis tuber in the active ingredient, the raw material crude drug Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis and the corydalis tuber that are used when according to extraction carry out being calculated as 0.2~5：0.2~5:0.05~2.The present invention utilizes Rhizoma Et Radix Notopterygii, the extract active ingredient by a certain percentage of three kinds of Chinese medicine of Radix Angelicae Sinensis and corydalis tuber, the dosage form for facilitating patient to use can be prepared into, can be that patient prevents primary dysmenorrhea and acquired dysmenorrhea, the present invention is matched using the Chinese medical extract of less type, and apparent curative effect is obtained in terms of prevention primary dysmenorrhea and acquired dysmenorrhea.
Description
Technical field
The present invention relates to Chinese medicine composition, more particularly it relates to a kind of prevention dysmenorrhoea, particularly suitable for prevention
The pharmaceutical composition of primary dysmenorrhea and acquired dysmenorrhea.
Background technology
Dysmenorrhoea refer to women's positive value menstrual period or through row before and after, there is periodical underbelly pain, or pain draws waist sacrum or even severe pain
Syncope person, primary dysmenorrhea are also known as functional dysmenorrhea, refer to reproductive organs without organic disease person.Its clinical symptoms includes headache
Weak, nausea and vomiting, dizziness, lumbocrural pain and diarrhea are gynecological diseases common in young woman, especially in hebetic female
Relatively conventional in property, incidence is about 30%~50%, seriously affects the physical and mental health of puberty women.Dysmenorrhoea belongs to Chinese medicine
" dysmenorrhea " scope, record of motherland's medicine in relation to dysmenorrhoea see Han dynasty Zhang Zhongjing earliest《Synopsis Golden Chamber the miscellaneous internal diseases in woman arteries and veins
Disease is simultaneously controlled》：" under band, menstrual disorders, lower abdominal pain and fullness ... ", it is believed that the occurrence and development of primary dysmenorrhea are yin and yang imbalance, qi and blood
Imbalance, viscera function is not normal cause punching that a stasis blocking, the circulation of born of the same parents official's menses is appointed to be obstructed caused by " not general rule pain ", " not flourish and pain ".Or because
Menstrual period brave the rain, paddle, swimming or menstrual period voracious raw food, and internal injury is in cold, or moves in wetland, and air-cooled cold-dampness visitor appoints in punching, in born of the same parents,
So that unsmooth through blood stagnation；Or element reports the deficiency of yang, yin-cold excess, the cold and deficiency of chong and ren channels causes through water running sluggishness, and stasis is not all right, stays poly-
And pain.Or element is mostly depressed, multiple condition of the injury will, irritability more stroke strongly fragrant, the Yu Ze stagnation of the circulation of vital energys before and after menstrual period or menstrual period, and then also the stasis of blood is stagnant for blood for the stagnation of the circulation of vital energy,
Sea of blood disorder of qi, menses operation is unsmooth, sends out as dysmenorrhoea.Or retention of damp-heat in the interior is hosted, streamer punching is appointed, and qi and blood or menstrual period sense are blocked
Damp and hot heresy, streamer are binded up one's hair in punching times, uterus, damp and hot mutually fight with menses as dysmenorrhoea.Or taste element reduction source is insufficient, qi and blood two
Void, punching appoint vessels of the uterus to lose in supporting, furthermore blood stagnancy due to deficiency of QI, the unsmooth and sore warp of QI-blood circulation.Or with the passing of time disease is prolonged, or lose and control misdiagnosis,
Healthy tendency is damaged, cold-heat jumble, qi and blood is unsmooth, caused by blood-stasis internal-depression.Modern medicine thinks dysmenorrhoea and Topical Prostaglandin, pressurization
It is related that element, oxytocins, estrogen production increase, progestational hormone generates reduction.It is also out of proportion with Endothelin and nitric oxide generation,
Intracellular calcium concentration increases related.Hypoplasia of uterus, lagedes uterus, neural factors, inherent cause, endocrine because
Elements etc. are also the possible cause for causing dysmenorrhoea.
Doctor trained in Western medicine mainly uses oral contraceptive, non-steroidal anti-inflammatory drugs, calcium ion channel blocker etc. to be treated, and obtains one
Fixed effect, but late result is not recorded mostly, and it is easy recurrent exerbation.Chinese medicine dysmenorrhoea, it is curative for effect, and side effect
Small, treating both manifestation and root cause of disease can play radical cure and preventive and therapeutic effect, but how pungent decoction flavour of a drug are, suffering drink, and decocting method time and effort consuming needs
Proved recipe, efficacious prescriptions make the dosage form of more convenient patient.
Invention content
The present invention overcomes the deficiencies in the prior art, a kind of experiment is provided, clinical is confirmed in primary dysmenorrhea, secondary pain
Through etc. have actively and sure effect Traditional Chinese medicine composition, with it is expected can be patient prevention primary dysmenorrhea and after
Hair property dysmenorrhoea.
In order to solve the above technical problems, one embodiment of the present invention uses following technical scheme：
It is a kind of prevention dysmenorrhoea pharmaceutical composition, the composition with the extract of Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis and corydalis tuber be effectively at
Point, it is collectively constituted with receptible auxiliary adding ingredient in drug, the extraction of Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis and corydalis tuber in the active ingredient
The parts by weight of the ratio of object, the raw material crude drug Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis and the corydalis tuber that are used when according to extraction carry out being calculated as 0.2~5：
0.2~5:0.05~2.
The extract of Rhizoma Et Radix Notopterygii is 0~100% ethyl alcohol of Rhizoma Et Radix Notopterygii in the active ingredient of the pharmaceutical composition of above-mentioned prevention dysmenorrhoea
Extract.It is the percentage by volume of ethyl alcohol to the percentage composition of ethyl alcohol involved in the application.
The extract of Radix Angelicae Sinensis is 0~100% ethyl alcohol of Radix Angelicae Sinensis in the active ingredient of the pharmaceutical composition of above-mentioned prevention dysmenorrhoea
Extract or Chinese angelica volatile oil, when the extract of Radix Angelicae Sinensis in active ingredient is Chinese angelica volatile oil, the quality of Ligustilide contains
Amount is not less than 30%.
The extract of corydalis tuber is the 0~100% of corydalis tuber in the active ingredient of the pharmaceutical composition of above-mentioned prevention dysmenorrhoea
Ethanol extract or corydalis alkaloid, when the extract of corydalis tuber in active ingredient is corydalis alkaloid, corydalis tuber
Alkaloid mass content is 5%~50%.
The pharmaceutical composition of above-mentioned prevention dysmenorrhoea can be oral type pharmaceutical preparation or external preparation, and external preparation includes breast
Agent, finish, liniment, patch and gelling agent.
The technical solution of the application is further detailed below.
The above-mentioned pharmaceutical composition of the present invention can be by current usual manner, by described drug effect according to needs are used
Drug ingedient is corresponding to acceptable in drug to assist adding ingredient, such as disintegrant, excipient, lubricant, adhesive, filling
Agent etc. is prepared into the available oral type drug including the common formulations such as tablet, dripping pill, capsule, pellet jointly
Preparation.Or suitable emulsifier is added, it is prepared into emulsion or creme.Suitable sodium alginate can also be added or is prepared by carbomer
At suitable gelling agent, suitable cataplasm can also be prepared.
The optimal proportion of active ingredient is 1 in above-mentioned composition：1：0.2.
Compared with prior art, the present invention at least has the advantages that：The present invention utilizes Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis and corydalis tuber
The extract of three kinds of Chinese medicine active ingredient by a certain percentage, can be prepared into the dosage form for facilitating patient to use, and it is former to be that patient prevents
Hair property dysmenorrhoea and acquired dysmenorrhea, the present invention are matched using the Chinese medical extract of less type, in prevention primary dysmenorrhea
Apparent curative effect is obtained in terms of acquired dysmenorrhea.
Specific implementation mode
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Embodiment 1
Rhizoma Et Radix Notopterygii 100g, Radix Angelicae Sinensis 500g, corydalis tuber 75g are ground into coarse powder, and steam distillation extraction volatile oil is spare, filtering,
Obtain jellyfish liquid and the dregs of a decoction.Jellyfish liquid is spare, and the dregs of a decoction add water decoction and extract secondary, filtering, decoction liquor and the conjunction of above-mentioned jellyfish liquid
And concentrate, add dextrin appropriate, particle 300g is made according to a conventional method, spray into volatile oil to obtain the final product.
Embodiment 2
Rhizoma Et Radix Notopterygii 500g, Radix Angelicae Sinensis 100g, corydalis tuber 200g add 70% alcohol reflux to extract 2 times, and filtering, filtrate merges, dense
Contracting, is added suitable edible oil to 1000ml.
Embodiment 3
Rhizoma Et Radix Notopterygii 200g, Radix Angelicae Sinensis 400g, corydalis tuber 100g are ground into coarse powder, and steam distillation extraction volatile oil is spare, mistake
Filter, obtains jellyfish liquid and the dregs of a decoction.Jellyfish liquid is spare, and the dregs of a decoction add water decoction and extract secondary, filtering, filtrate addition proper proportion
Tween, glyceryl laurate ester are slowly stirred the lower above-mentioned jellyfish liquid of addition, are prepared into the emulsion of 1000ml.
Embodiment 4
Rhizoma Et Radix Notopterygii 400g, Radix Angelicae Sinensis 200g, corydalis tuber 150g add 50% alcohol reflux to extract 3 times, and filtering, filtrate merges, dense
Contracting, dry, pulverize, add right amount of auxiliary materials, be prepared into 1000 patches.
Embodiment 5
Rhizoma Et Radix Notopterygii 400g, corydalis tuber 75g, are ground into coarse powder, are extracted with 90% ethanol percolation, collect 8 times of percolates, and low temperature subtracts
Pressure recycling design is concentrated into medicinal extract, be added Chinese angelica volatile oil prepared by conventional method (based on crude drug in whole, 200g, Ligustilide
Mass content is 30%), appropriate sodium alginate to be added, and water is added to be prepared into the exterior-applied gel of 1000ml.
Embodiment 6
Rhizoma Et Radix Notopterygii 400g is extracted 3 times with 70% alcohol reflux, collects 8 times of percolates, and low-temperature reduced-pressure recycling design is concentrated into
Chinese angelica volatile oil (based on crude drug in whole, 200g) prepared by conventional method is added in medicinal extract, and the corydalis alkaloid routinely prepared is added
(based on crude drug in whole, 100g, corydalis alkaloid mass content is 10%), appropriate sodium alginate to be added, water is added to be prepared into
The exterior-applied gel of 1000ml.
Following experiments are carried out using the pharmaceutical composition obtained by above-described embodiment as trial drug.
Embodiment 7
Rhizoma Et Radix Notopterygii 400g, Radix Angelicae Sinensis 400g, corydalis tuber 80g add 70% alcohol reflux to extract 3 times, and filtering, filtrate merges, concentration,
Suitable edible oil is added to 1000ml.
Embodiment 8
Rhizoma Et Radix Notopterygii 400g, Radix Angelicae Sinensis 400g, corydalis tuber 80g add 50% alcohol reflux to extract 3 times, and filtering, filtrate merges, concentration,
It dry, pulverize, add right amount of auxiliary materials, be prepared into 1000 patches.
1 material
1.1 experimental drug
Examples 1 to 8 is prepared by pharmacy institute of our unit according to above-mentioned implementing method.Dosage presses crude drug in whole g/kg
It calculates.
Oestradiol benzoate (Shanghai General Pharmaceutical Co., ltd., lot number 090502)；Oxytocin injection (Shanghai
The production of Zhu Yi Jin pharmaceutcal corporation, Ltd of commission upper Hisense of one Biochemical Drugs industry Co., Ltd, lot number 091062).
1.2 experimental animal
Mouse：Kunming mouse, female, SPF grades of animals are provided by Sichuan Provincial Academy of Traditional Chinese Medicine Experimental Animal Center.
2 methods and result
Influence of the 2.1 different primary medicinal powder formula rates to dysmenorrhoea animal model
It is the female mice of 22~24g to take weight, by the grouping administration at random of table 1, in addition to control group, the equal abdominal cavity of remaining animal
Inject 10 mg/kg of estradiol benzoate injection, 1 time a day, continuous 5 d.Estradiol benzoate injection was injected at the 5th day
Afterwards simultaneously by dosage gastric infusion (crude drug in whole beats powder) 1 time, 1 h after gastric infusion shown in table 1,30 U/ of intraperitoneal injection oxytocins
Kg records the writhing number of mouse in 30 min after injecting, the results are shown in Table 1 using writhing response as the index of uterus strong contraction.
Influence (x ± S) of the different primary medicinal powder of table 1 to oxytocin induced mice writhing response
| Sample | Dosage (crude drug in whole g/kg) | Mouse quantity (only) | Writhing number (secondary) |
| Control | 0 | 10 | 0.7±0.2*** |
| Model | 0 | 10 | 30.5±4.9 |
| Rhizoma Et Radix Notopterygii | 5 | 10 | 29.8±4.1 |
| Radix Angelicae Sinensis | 5 | 10 | 28.4±3.6 |
| Corydalis tuber | 1 | 10 | 27.9±5.3 |
| Rhizoma Et Radix Notopterygii+Radix Angelicae Sinensis | 5+5 | 10 | 24.6±5.2* |
| Rhizoma Et Radix Notopterygii+corydalis tuber | 5+1 | 10 | 23.7±6.1* |
| Radix Angelicae Sinensis+corydalis tuber | 5+1 | 10 | 25.4±5.7* |
| Rhizoma Et Radix Notopterygii+Radix Angelicae Sinensis+corydalis tuber | 5+5+1 | 10 | 14.2±3.1*** |
| Codeine phosphate | 30mg/kg | 10 | 21.5±5.6** |
Note：Compared with model group：*P<0.05,**P<0.01,***P<0.001。
As seen from Table 1, writhing response number showed increased in 30 min of model group mouse, compared with the control group difference have
Statistical significance.When Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis and corydalis tuber are used alone, each drug to dysmenorrhea model mouse without apparent analgesic activity,
It is more not statistically significant with model group.When Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis, corydalis tuber compatible use two-by-two, certain addition is shown
Effect has statistical significance with model group comparing difference.When three medicines are used in combination, synergistic effect significantly increases, with mould
Type group comparing difference has statistical significance.Prompt, Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis, corydalis tuber triple combination are used to have when dysmenorrhoea significant
Synergistic function.
Influence of the 2.2 different extract formula rates to dysmenorrhoea animal model
It is the female mice of 22~24g to take weight, by the grouping administration at random of table 2, in addition to control group, the equal abdominal cavity of remaining animal
Inject estradiol benzoate injection 10mg/kg, 1 time a day, continuous 5d.After estradiol benzoate injection being injected at the 5th day
Simultaneously by dosage gastric infusion (alcohol extract) 1 time, 1h after gastric infusion shown in table 2, oxytocins 30U/kg is injected intraperitoneally, with writhing
Reaction is the index of uterus strong contraction, records the writhing number of mouse in 30min after injecting, the results are shown in Table 2.
Influence (x ± S) of the different extraction composition formulas of table 2 to oxytocin induced mice writhing response
| Sample | Dosage (crude drug in whole g/kg) | Mouse quantity (only) | Writhing number (secondary) |
| Control | 0 | 10 | 0.6±0.3*** |
| Model | 0 | 10 | 29.7±5.4 |
| Rhizoma Et Radix Notopterygii | 5 | 10 | 28.9±5.3 |
| Radix Angelicae Sinensis | 2 | 10 | 27.6±5.2 |
| Corydalis tuber | 1 | 10 | 28.4±3.5 |
| Rhizoma Et Radix Notopterygii+Radix Angelicae Sinensis | 5+2 | 10 | 24.7±6.1* |
| Rhizoma Et Radix Notopterygii+corydalis tuber | 5+1 | 10 | 24.6±3.7* |
| Radix Angelicae Sinensis+corydalis tuber | 2+1 | 10 | 26.3±6.5* |
| Rhizoma Et Radix Notopterygii+Radix Angelicae Sinensis+corydalis tuber | 5+2+1 | 10 | 16.1±2.5*** |
| Rhizoma Et Radix Notopterygii+Radix Angelicae Sinensis+corydalis tuber | 5+5+1 | 10 | 14.6±2.9*** |
| Codeine phosphate | 30mg/kg | 10 | 22.4±5.1** |
Compared with model group：*P<0.05,**P<0.01,***P<0.001。
As seen from Table 2, writhing response number showed increased in model group mouse 30min, compared with the control group difference have
Statistical significance.When the alcohol extract of Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis and corydalis tuber is used alone, each drug is to dysmenorrhea model mouse without apparent town
Pain acts on, more not statistically significant with model group.When Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis, corydalis tuber compatible use two-by-two, show certain
Summation action, with model group comparing difference have statistical significance.When three medicines are used in combination, act synergistically and significantly increase
By force, there is statistical significance with model group comparing difference.Prompt, Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis, corydalis tuber triple combination are used to have when dysmenorrhoea
Significant synergistic function, while also indicating that the effect of the alcohol extract of three may be more preferable.
Influence of the 2.3 different embodiment resulting compositions to dysmenorrhoea animal model
Kunming kind female mice 110 is taken, is randomly divided into Normal group after claiming quality status stamp, dysmenorrhea model group is implemented
Example 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5, embodiment 6, embodiment 7, embodiment 8 and positive drug group, every group 10
Only.Primary dysmenorrhea model is manufactured with oestradiol benzoate and oxytocin.By 10mg/kg intraperitoneal injection oestradiol benzoate injections
Liquid, continuous 5d, to increase sensibility of the uterine smooth muscle to drug.Dosage shown in table 1 is pressed simultaneously by the combination of Examples 1 to 8
Object gastric infusion or in its abdomen hair removal section (3*3cm2) the corresponding external preparation of even spread, positive drug group gastric infusion phosphoric acid can
Wait for because.In 1h after the last administration, oxytocins 30U/kg is injected intraperitoneally, using writhing response as the index of uterus strong contraction, record
After injection in 30min mouse writhing incidence and number, the results are shown in Table 3.
Influence (x ± S) of the different embodiments of table 3 to oxytocin induced mice pain writhing response
| Sample | Dosage (crude drug in whole g/kg) | N | Writhing number (secondary) |
| Control | 0 | 10 | 0.6±0.3*** |
| Model | 0 | 10 | 25.4±5.6 |
| Embodiment 1 | 7 | 10 | 19.3±3.7* |
| Embodiment 2 | 3.5 | 10 | 17.4±6.5* |
| Embodiment 3 | 3.5 | 10 | 18.5±5.3* |
| Embodiment 4 | 3.5 | 10 | 19.6±4.8* |
| Embodiment 5 | 3.5 | 10 | 18.9±5.7* |
| Embodiment 6 | 3.5 | 10 | 19.2±5.1* |
| Embodiment 7 | 3.5 | 10 | 15.8±6.1* |
| Embodiment 8 | 3.5 | 10 | 16.1±5.2* |
| Codeine phosphate | 30mg/kg | 10 | 19.3±5.6* |
Compared with model group：*P<0.05,***P<0.001。
As seen from Table 3, writhing response number showed increased in model group mouse 30min.Compared with model group, institute of the present invention
There is embodiment mouse writhing reaction times can be made to be substantially reduced, difference has statistical significance.Meanwhile it can be with from table 3
Find out, compared with oral preparation, embodiment 2~8 as external preparation its curative effect and oral system in the case where dosage halves
Agent full dose is suitable, prompts the effect that the medicine prevents dysmenorrhoea as external preparation more preferable than for oral administration.
Although reference be made herein to invention has been described for explanatory embodiment of the invention, however, it is to be understood that ability
Field technique personnel can be designed that a lot of other modification and implementations, these modifications and implementations will be fallen in the application public affairs
Within the scope and spirit opened.It more specifically, can be to the group of theme combination layout in range disclosed in the present application
A variety of variations and modifications are carried out at component and/or layout.In addition to variations and improvements to the component parts and or layout,
To those skilled in the art, other purposes also will be apparent.
Claims (5)
1. a kind of pharmaceutical composition of prevention dysmenorrhoea, it is characterised in that the composition is with the extract of Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis and corydalis tuber
It is collectively constituted for receptible auxiliary adding ingredient in active ingredient, with drug, Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis and Yan Hu in the active ingredient
The parts by weight of the ratio of the extract of rope, the raw material crude drug Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis and the corydalis tuber that are used when according to extraction are calculated as
0.2~5：0.2~5:0.05~2.
2. the pharmaceutical composition of prevention dysmenorrhoea according to claim 1, it is characterised in that the extraction of Rhizoma Et Radix Notopterygii in active ingredient
Object is 0~100% ethanol extract of Rhizoma Et Radix Notopterygii.
3. the pharmaceutical composition of prevention dysmenorrhoea according to claim 1, it is characterised in that the extraction of Radix Angelicae Sinensis in active ingredient
Object is 0~100% ethanol extract or Chinese angelica volatile oil of Radix Angelicae Sinensis, when the extract of Radix Angelicae Sinensis in active ingredient is Chinese angelica volatile oil
When, the mass content of Ligustilide is not less than 30%.
4. the pharmaceutical composition of prevention dysmenorrhoea according to claim 1, it is characterised in that corydalis tuber carries in active ingredient
It is 0~100% ethanol extract or corydalis alkaloid of corydalis tuber to take object, when the extract of corydalis tuber in active ingredient is to prolong
When Hu rope alkaloid, corydalis alkaloid mass content is 5%~50%.
5. the pharmaceutical composition of the prevention dysmenorrhoea according to Claims 1 to 4 any one, it is characterised in that the pharmaceutical composition
Object is oral type pharmaceutical preparation or external preparation, and external preparation includes emulsion, finish, liniment, patch and gelling agent.
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