CN108413082B - Quick connector of micro-fluidic system - Google Patents
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- 238000007789 sealing Methods 0.000 claims abstract description 29
- 230000006835 compression Effects 0.000 claims abstract description 23
- 238000007906 compression Methods 0.000 claims abstract description 23
- 238000003825 pressing Methods 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims description 13
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- 229910052755 nonmetal Inorganic materials 0.000 claims description 2
- 239000007788 liquid Substances 0.000 abstract description 13
- 238000012864 cross contamination Methods 0.000 abstract description 9
- 238000002788 crimping Methods 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000000034 method Methods 0.000 description 11
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- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K15/00—Check valves
- F16K15/02—Check valves with guided rigid valve members
- F16K15/04—Check valves with guided rigid valve members shaped as balls
- F16K15/044—Check valves with guided rigid valve members shaped as balls spring-loaded
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- Quick-Acting Or Multi-Walled Pipe Joints (AREA)
Abstract
一种微流控系统的快速接头，涉及一种微流控系统的连接装置。本发明是要解决现有微流控装置与外部管路接口难以实现自动连接、连接精度低、所需时间长、容易泄漏、容易产生液体间交叉污染的技术问题。本发明由单向阀、压紧夹、密封圈和开关杆组成；开关杆的一端通过单向阀的出口固定在球形阀芯上，密封圈套在单向阀的出口外壁；压紧夹夹在单向阀的出口外壁，压紧夹和密封圈紧密接触，且压紧夹相比密封圈更靠近球形阀芯。本发明微流控系统的快速接头结构简单便于制作和使用，采用压接的方式与微流道进口连接并自动打开或关闭，无需旋转或插入连接。
A quick connector for a microfluidic system relates to a connection device for a microfluidic system. The invention aims to solve the technical problems that the existing microfluidic device and the external pipeline interface are difficult to realize automatic connection, the connection precision is low, the required time is long, the leakage is easy, and the cross-contamination between liquids is easy to occur. The invention consists of a one-way valve, a pressing clamp, a sealing ring and a switch rod; one end of the switch rod is fixed on the spherical valve core through the outlet of the one-way valve, and the sealing ring is sleeved on the outer wall of the one-way valve outlet; On the outer wall of the outlet of the check valve, the compression clamp and the sealing ring are in close contact, and the compression clamp is closer to the spherical valve core than the sealing ring. The quick connector of the microfluidic control system of the present invention has a simple structure and is convenient to manufacture and use, and is connected to the inlet of the microfluidic channel by means of crimping and automatically opens or closes without rotating or inserting the connection.
Description
技术领域technical field
本发明涉及一种微流控系统的快速接头，属于微流控技术领域。The invention relates to a quick connector of a microfluidic system, belonging to the technical field of microfluidics.
背景技术Background technique
微流控系统广泛应用于微量药物注射、微流控芯片、微量给水给药、微量流体分析以及生物医学分析中微量进样等场合。在应用过程中常常需要将所液体样品或反应液、清洗液等通过外部管路快速高效地注入微流控装置。目前的连接接口主要采用钢管或接头与PDMS或PMMA等材料制作的微流控装置基底流道入口进行手动插入连接或旋转连接，所需时间长且连接精度低，难以实现自动连接。目前的压接式接头由于不属于快速换接接头，在接头脱开时，试剂容易泄漏，导致液体间交叉污染。随着微流控系统自动化程度的提高，微流控装置与外部管路的自动连接和分离成为越来越急待于解决的关键问题。Microfluidic systems are widely used in micro-drug injection, micro-fluidic chips, micro-water administration, micro-fluid analysis, and micro-injection in biomedical analysis. In the application process, it is often necessary to inject the liquid sample or reaction solution, cleaning solution, etc. into the microfluidic device quickly and efficiently through an external pipeline. The current connection interfaces mainly use steel pipes or joints to manually insert or rotate the inlet of the microfluidic device base flow channel made of PDMS or PMMA materials. Since the current crimp joint is not a quick-change joint, when the joint is disengaged, the reagent is easy to leak, resulting in cross-contamination between liquids. With the improvement of the automation degree of the microfluidic system, the automatic connection and separation of the microfluidic device and the external pipeline has become an increasingly urgent key problem to be solved.
发明内容SUMMARY OF THE INVENTION
本发明是要解决现有的微流控装置与外部管路接口难以实现自动连接、连接精度低、所需时间长、容易泄漏、容易产生液体间交叉污染的技术问题，而提供一种微流控系统的快速接头。The present invention is to solve the technical problems that the existing microfluidic device and the external pipeline interface are difficult to realize automatic connection, the connection precision is low, the required time is long, the leakage is easy, and the cross-contamination between liquids is easy to generate, and provides a microfluidic device. Quick connector for the control system.
本发明的一种微流控系统的快速接头是由单向阀、压紧夹4、密封圈5和开关杆6组成；A quick connector of a microfluidic system of the present invention is composed of a one-way valve, a
所述的单向阀是由阀体1、弹簧2和球形阀芯3组成；The one-way valve is composed of a
所述的阀体1的两端分别为单向阀的进口1-1和出口1-2，单向阀的进口1-1和出口1-2的直径均小于中间部分的直径；The two ends of the
球形阀芯3设置在阀体1中间部分的内部且靠近单向阀的出口1-2，弹簧2设置在阀体1中间部分的内部且靠近单向阀的进口1-1，弹簧2处于压缩状态，弹簧2的两端分别紧压着球形阀芯3和单向阀的进口1-1；The
开关杆6的一端通过单向阀的出口1-2固定在球形阀芯3上，密封圈5套在单向阀的出口1-2的外壁，且密封圈5的一端与单向阀的出口1-2的外端面平齐；压紧夹4夹在单向阀的出口1-2外壁，压紧夹4和密封圈5紧密接触，且压紧夹4相比密封圈5更靠近球形阀芯3。One end of the
本发明微流控系统快速接头的使用方法和原理为：The use method and principle of the microfluidic system quick connector of the present invention are:
一、连接：将本发明微流控系统快速接头的单向阀出口1-2竖直向下对准微流控装置基底的流道入口，并使开关杆6的自由端接触到微流控装置基底的底面，对压紧夹4施加向下的外力，使得密封圈5的下端面紧压在微流控装置基底的上表面且与微流控装置的上表面密封，此时开关杆6的自由端由于受到微流控装置基底面的推力进一步顶开单向阀内的球形阀芯3使单向阀处于连通状态，实现微流控系统与外部连接管路液体流道的连通，完成管路连接动作；1. Connection: Align the one-way valve outlet 1-2 of the microfluidic system quick connector of the present invention with the flow channel inlet of the microfluidic device substrate vertically downward, and make the free end of the
二、脱开：撤掉对压紧夹4向下压紧的外力，微流控系统的快速接头离开微流控装置基底即可，快速接头内部单向阀的球形阀芯3在弹簧2作用下重新关闭阀口，保证了管路的脱开和闭合，并防止了微流控装置内部液体倒流而产生交叉污染；2. Disengagement: remove the external force pressing down on the
三、重复使用时只需循环过程一、过程二即可。3. Only cycle process one and process two can be used repeatedly.
本发明的优点：Advantages of the present invention:
本发明所述的微流控系统快速接头能够解决现有的微流控装置与外部管路接口难以实现自动连接，连接精度低，所需时间长，容易泄漏，容易产生液体间交叉污染等问题，且结构简单便于制作和使用，连接和脱开快速高效，工作效率提高50％。采用压接的方式与微流道进口连接并自动打开或关闭，无需插入式连接或旋转连接。The microfluidic system quick connector of the present invention can solve the problems that the existing microfluidic device and the external pipeline interface are difficult to realize automatic connection, the connection accuracy is low, the required time is long, it is easy to leak, and it is easy to cause cross-contamination between liquids and the like. , and the structure is simple and easy to manufacture and use, the connection and disconnection are fast and efficient, and the work efficiency is increased by 50%. It is connected to the inlet of the microchannel by crimping and automatically opens or closes, without the need for plug-in connection or rotary connection.
附图说明Description of drawings
图1为具体实施方式一的微流控系统的快速接头示意图；1 is a schematic diagram of a quick connector of a microfluidic system according to
图2为具体实施方式一的微流控系统的快速接头工作时示意图；2 is a schematic diagram of the quick connector of the microfluidic system of the
图3为具体实施方式一的单向阀示意图。FIG. 3 is a schematic diagram of a one-way valve according to
具体实施方式Detailed ways
具体实施方式一：本实施方式为一种微流控系统的快速接头，如图1-图3，具体是由单向阀、压紧夹4、密封圈5和开关杆6组成；Embodiment 1: This embodiment is a quick connector of a microfluidic system, as shown in FIGS. 1-3 , which is specifically composed of a one-way valve, a
所述的单向阀是由阀体1、弹簧2和球形阀芯3组成；The one-way valve is composed of a
所述的阀体1的两端分别为单向阀的进口1-1和出口1-2，单向阀的进口1-1和出口1-2的直径均小于中间部分的直径；The two ends of the
球形阀芯3设置在阀体1中间部分的内部且靠近单向阀的出口1-2，弹簧2设置在阀体1中间部分的内部且靠近单向阀的进口1-1，弹簧2处于压缩状态，弹簧2的两端分别紧压着球形阀芯3和单向阀的进口1-1；The
开关杆6的一端通过单向阀的出口1-2固定在球形阀芯3上，密封圈5套在单向阀的出口1-2的外壁，且密封圈5的一端与单向阀的出口1-2的外端面平齐；压紧夹4夹在单向阀的出口1-2外壁，压紧夹4和密封圈5紧密接触，且压紧夹4相比密封圈5更靠近球形阀芯3。One end of the
本实施方式微流控系统快速接头的使用方法和原理为：The usage method and principle of the microfluidic system quick connector of this embodiment are as follows:
一、连接：将本发明微流控系统快速接头的单向阀出口1-2竖直向下对准微流控装置基底的流道入口，并使开关杆6的自由端接触到微流控装置基底的底面，对压紧夹4施加向下的外力，使得密封圈5的下端面紧压在微流控装置基底的上表面且与微流控装置的上表面密封，此时开关杆6的自由端由于受到微流控装置基底面的推力进一步顶开单向阀内的球形阀芯3使单向阀处于连通状态，实现微流控系统与外部连接管路液体流道的连通，完成管路连接动作；1. Connection: Align the one-way valve outlet 1-2 of the microfluidic system quick connector of the present invention with the flow channel inlet of the microfluidic device substrate vertically downward, and make the free end of the
二、脱开：撤掉对压紧夹4向下压紧的外力，微流控系统的快速接头离开微流控装置基底即可，快速接头内部单向阀的球形阀芯3在弹簧2作用下重新关闭阀口，保证了管路的脱开和闭合，并防止了微流控装置内部液体倒流而产生交叉污染；2. Disengagement: remove the external force pressing down on the
三、重复使用时只需循环过程一、过程二即可。3. Only cycle process one and process two can be used repeatedly.
本实施方式的优点：The advantages of this embodiment:
本实施方式所述的微流控系统快速接头能够解决现有的微流控装置与外部管路接口难以实现自动连接，连接精度低，所需时间长，容易泄漏，容易产生液体间交叉污染等问题，且结构简单便于制作和使用，连接和脱开快速高效，工作效率提高50％。采用压接的方式与微流道进口连接并自动打开或关闭，无需插入式连接或旋转连接。The quick connector of the microfluidic system described in this embodiment can solve the problem that the existing microfluidic device and the external pipeline interface are difficult to realize automatic connection, the connection accuracy is low, the time required is long, it is easy to leak, and it is easy to generate cross-contamination between liquids, etc. The utility model has the advantages of simple structure, convenient production and use, fast and efficient connection and disconnection, and 50% increase in work efficiency. It is connected to the inlet of the microchannel by crimping and automatically opens or closes, without the need for plug-in connection or rotary connection.
具体实施方式二：本实施方式与具体实施方式一不同的是：所述的压紧夹4的材质为不锈钢或塑料。其他与具体实施方式一相同。Embodiment 2: The difference between this embodiment and
具体实施方式三：本实施方式与具体实施方式一或二不同的是：所述的密封圈5的材质为橡胶。其他与具体实施方式一或二相同。Embodiment 3: The difference between this embodiment and
具体实施方式四：本实施方式与具体实施方式一至三之一不同的是：所述的开关杆6的材质为不锈钢或塑料。其他与具体实施方式一至三之一相同。Embodiment 4: The difference between this embodiment and one of
具体实施方式五：本实施方式与具体实施方式一至四之一不同的是：所述的阀体1的材质为金属或非金属。其他与具体实施方式一至四之一相同。Embodiment 5: The difference between this embodiment and one of
用以下试验对本发明进行验证：The present invention was verified with the following experiments:
试验一：本试验为一种微流控系统的快速接头，如图1-图3，具体是由单向阀、压紧夹4、密封圈5和开关杆6组成；Test 1: This test is a quick connector for a microfluidic system, as shown in Figure 1-Figure 3, which is specifically composed of a one-way valve, a
所述的单向阀是由阀体1、弹簧2和球形阀芯3组成；The one-way valve is composed of a
所述的阀体1的两端分别为单向阀的进口1-1和出口1-2，单向阀的进口1-1和出口1-2的直径均小于中间部分的直径；The two ends of the
球形阀芯3设置在阀体1中间部分的内部且靠近单向阀的出口1-2，弹簧2设置在阀体1中间部分的内部且靠近单向阀的进口1-1，弹簧2处于压缩状态，弹簧2的两端分别紧压着球形阀芯3和单向阀的进口1-1；The
开关杆6的一端通过单向阀的出口1-2固定在球形阀芯3上，密封圈5套在单向阀的出口1-2的外壁，且密封圈5的一端与单向阀的出口1-2的外端面平齐；压紧夹4夹在单向阀的出口1-2外壁，压紧夹4和密封圈5紧密接触，且压紧夹4相比密封圈5更靠近球形阀芯3；One end of the
所述的压紧夹4的材质为不锈钢；The material of the described
所述的密封圈5的材质为橡胶；The material of the sealing
所述的开关杆6的材质为不锈钢；The material of the
所述的阀体1的材质为金属。The material of the
本试验微流控系统快速接头的使用方法和原理为：The use method and principle of the quick connector of the microfluidic system in this experiment are as follows:
一、连接：将本发明微流控系统快速接头的单向阀出口1-2竖直向下对准微流控装置基底的流道入口，并使开关杆6的自由端接触到微流控装置基底的底面，对压紧夹4施加向下的外力，使得密封圈5的下端面紧压在微流控装置基底的上表面且与微流控装置的上表面密封，此时开关杆6的自由端由于受到微流控装置基底面的推力进一步顶开单向阀内的球形阀芯3使单向阀处于连通状态，实现微流控系统与外部连接管路液体流道的连通，完成管路连接动作；1. Connection: Align the one-way valve outlet 1-2 of the microfluidic system quick connector of the present invention with the flow channel inlet of the microfluidic device substrate vertically downward, and make the free end of the
二、脱开：撤掉对压紧夹4向下压紧的外力，微流控系统的快速接头离开微流控装置基底即可，快速接头内部单向阀的球形阀芯3在弹簧2作用下重新关闭阀口，保证了管路的脱开和闭合，并防止了微流控装置内部液体倒流而产生交叉污染；2. Disengagement: remove the external force pressing down on the
三、重复使用时只需循环过程一、过程二即可。3. Only cycle process one and process two can be used repeatedly.
本试验的优点：Advantages of this test:
本试验所述的微流控系统快速接头能够解决现有的微流控装置与外部管路接口难以实现自动连接，连接精度低，所需时间长，容易泄漏，容易产生液体间交叉污染等问题，且结构简单便于制作和使用，连接和脱开快速高效，工作效率提高50％。采用压接的方式与微流道进口连接并自动打开或关闭，无需插入式连接或旋转连接。The quick connector of the microfluidic system described in this experiment can solve the problems that the existing microfluidic device and the external pipeline interface are difficult to realize automatic connection, the connection accuracy is low, the time required is long, it is easy to leak, and it is easy to cause cross-contamination between liquids. , and the structure is simple and easy to manufacture and use, the connection and disconnection are fast and efficient, and the work efficiency is increased by 50%. It is connected to the inlet of the microchannel by crimping and automatically opens or closes, without the need for plug-in connection or rotary connection.
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| US5048578A (en) * | 1990-03-01 | 1991-09-17 | Arkady Dorf | Oil drainage coupler |
| CN201215206Y (en) * | 2008-06-18 | 2009-04-01 | 冯建洪 | Throttle valve for independent air supply cages |
| CN202629095U (en) * | 2012-06-11 | 2012-12-26 | 重庆瑞信气体有限公司 | Automatic blocking inflation valve |
| CN203036136U (en) * | 2012-11-29 | 2013-07-03 | 海盐管件制造有限公司 | High pressure detachable type ball sealing pressure measuring connector |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN108413082A (en) | 2018-08-17 |
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