CN108404052A - Prevention myopia, the pharmaceutical composition and the preparation method and application thereof of amblyopia - Google Patents
Prevention myopia, the pharmaceutical composition and the preparation method and application thereof of amblyopia Download PDFInfo
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- CN108404052A CN108404052A CN201810439199.6A CN201810439199A CN108404052A CN 108404052 A CN108404052 A CN 108404052A CN 201810439199 A CN201810439199 A CN 201810439199A CN 108404052 A CN108404052 A CN 108404052A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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Abstract
The present invention relates to a kind of prevention myopia, the pharmaceutical composition and the preparation method and application thereof of amblyopia, the raw material components of pharmaceutical composition include：The Chinese medicines such as borneol, peppermint, cassia seed, Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary, Poria cocos, the leaf of bamboo, the tuber of pinellia, Radix Salviae Miltiorrhizae, rhizoma imperatae, Herba Cistanches, Rhizoma Chuanxiong, the root of bidentate achyranthes, HERBA ANDROGRAPHITID and Moschus.The present invention, as raw material components, and carries out scientific matching by using several kinds of Chinese medicinal materials, and the pharmaceutical composition tool being prepared prevents and/or the effect for the treatment of myopia, amblyopia, quick, significant effect, and safety is without side-effects；Preparation method is simple, and production cost is low, easy to use, has good commercial promise.
Description
Technical field
The present invention relates to field of medicine preparing technology, and in particular to it is a kind of prevention myopia, amblyopia pharmaceutical composition and its
Preparation method and application.
Background technology
Myopia is also referred to as short-sighted eye, is typically only capable to see close and regard remote unclear；When being in resting state, come from unlimited distance
Directional light assembles focus after the dioptric system refractive power of eye before retina, on the retina then formed do not know
Picture.Amblyopia refers to eyeball without significant organic pathology, and simple eye or eyes are most preferably corrected defects of vision less than the eyesight at corresponding age；Or
Binocular vision differs two rows or more, and the relatively low eye of eyesight is amblyopia.Amblyopia is the eye disease being closely related with visual development, is shown as
Different degrees of visual loss is showed during development of vision system, usually simple eye involvement.Monocular squint, antimetropia,
Highly ametropia, form deprivation is its common pathogenic factor.Amblyopia is a kind of eye disease seriously endangering children's visual function, portion
Point amblyopia can restore normal by treating, and find more early, and treatment is more timely, and prognosis is better, be such as not treated in time can cause it is weak
Depending on exacerbation, or even blindness.Currently, with the increase of learning life pressure, the incidence of myopia and amblyopia is all improving, university student
Near-sighted incidence be up to 70% or more.Although prevention myopia, the method for amblyopia and drug are numerous in the market, effect is mostly not
It is too ideal, or there are apparent side effects.
Invention content
For the defects in the prior art, present invention aims at a kind of prevention myopia of offer, the pharmaceutical compositions of amblyopia
And the preparation method and application thereof, the medication effect is notable, quick, without any side effects；Application method is simple.
To achieve the above object, technical solution provided by the invention is：
The present invention provides it is a kind of prevention myopia, amblyopia pharmaceutical composition, raw material components by weight, including：Ice
10~20 parts by weight of piece, 5~7 parts by weight of peppermint, 2~4 parts by weight of cassia seed, 5~10 parts by weight of Radix Paeoniae Alba, 15~20 weight of Fructus Forsythiae
Part, 10~15 parts by weight of curcuma zedoary, 5~10 parts by weight of Poria cocos, 6~10 parts by weight of the leaf of bamboo, 12~20 parts by weight of the tuber of pinellia, Radix Salviae Miltiorrhizae 6~8
Parts by weight, 10~14 parts by weight of rhizoma imperatae, 2~4 parts by weight of Herba Cistanches, 5~7 parts by weight of Rhizoma Chuanxiong, 7~11 parts by weight of the root of bidentate achyranthes, olive
3~6 parts by weight of 12~15 parts by weight of core lotus and Moschus.
Preferably, the raw material components of pharmaceutical composition further include：6~10 parts by weight of caulis trachelospermi, 3~8 parts by weight of Longstamen Onion Bulb, pool
Blue 2~5 parts by weight, 4~9 parts by weight of 5~10 parts by weight of agalloch eaglewood and inular flower.
Preferably, the raw material components of pharmaceutical composition by weight, including：15 parts by weight of borneol, 6 parts by weight of peppermint,
3 parts by weight of cassia seed, 7 parts by weight of Radix Paeoniae Alba, 16 parts by weight of Fructus Forsythiae, 12 parts by weight of curcuma zedoary, 8 parts by weight of Poria cocos, 8 parts by weight of the leaf of bamboo,
16 parts by weight of the tuber of pinellia, 7 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of rhizoma imperatae, 3 parts by weight of Herba Cistanches, 6 parts by weight of Rhizoma Chuanxiong, 9 weight of the root of bidentate achyranthes
Part, 14 parts by weight of HERBA ANDROGRAPHITID, 4 parts by weight of Moschus, 8 parts by weight of caulis trachelospermi, 5 parts by weight of Longstamen Onion Bulb, 3 parts by weight of Herba Lycopi, 7 weight of agalloch eaglewood
Part and 6 parts by weight of inular flower.
The present invention provides a kind of prevention myopia, the preparation method of the pharmaceutical composition of amblyopia, including steps：By all originals
Material component mixes in proportion, is then ground to powder, obtains Chinese medicine composition.
Preferably, in prevention myopia, the preparation method of the pharmaceutical composition of amblyopia, the grain size of powder is no more than 0.001mm.
The present invention also provides another prevention myopia, the preparation method of the pharmaceutical composition of amblyopia, including steps：It will be white
Water is added after Chinese herbaceous peony, Fructus Forsythiae, curcuma zedoary and Poria cocos mixing, after impregnating preset time, adjusts pH value to 4.5~4.8, is then decocted
Extraction；After extraction, filtrate is collected in filtering；Filtrate is dried, other surplus stock components are then added, then pulverize
End obtains pharmaceutical composition.
Preferably, in prevention myopia, the preparation method of the pharmaceutical composition of amblyopia, Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos it is total
The ratio of quality and the quality of water is 1:(10~15).
Preferably, in prevention myopia, the preparation method of the pharmaceutical composition of amblyopia, the temperature of immersion is 45~55 DEG C, leaching
The time of bubble is 12~14h；The time for decocting extraction is 40~50min.
Preferably, in prevention myopia, the preparation method of the pharmaceutical composition of amblyopia, the grain size of powder is no more than 0.001mm.
The present invention also protects pharmaceutical composition preparing prevention and/or treatment myopia, the drug of amblyopia and/or drug addition
Application in agent.
It should be noted that prevention myopia, the application method of the pharmaceutical composition of amblyopia that the present invention is prepared are preferred
For：Pharmaceutical composition is put into the happy mesh instrument of dredging collateral, so that the active constituent in pharmaceutical composition is directly acted on eye by stifling
Portion improves ocular cell and blood circulation, and anti-eye strain restores ciliary muscle elasticity, and dredging the channel, the promoting flow of qi and blood circulation makes silt
The passages through which vital energy circulates of resistance is unimpeded, fully reinforces the natural curability to eye illnesses such as myopia, amblyopias.
Certainly, the pharmaceutical composition that prepared by the above method can be further prepared into pharmaceutically acceptable dose as needed
Type.In addition, also belonging to protection scope of the present invention by drug made of active constituent of aforementioned pharmaceutical compositions.By will be above-mentioned
Pharmaceutical composition is prepared after directly preparing or being added pharmaceutically acceptable auxiliary material, can be made into any pharmaceutically acceptable
Dosage form.Include by taking external preparation as an example：Solution, patch, vina, tincture, gelling agent, liniment, aerosol, spray, ointment
Agent and plastics.The drug of above-mentioned various dosage forms can be prepared according to the conventional method of pharmaceutical field；It should be in this hair
In bright protection domain.
Technical solution provided by the invention has following advantageous effect：(1) present invention by using Radix Paeoniae Alba, Fructus Forsythiae and
The Chinese medicines such as curcuma zedoary carry out scientific matching as raw material components, and the pharmaceutical composition being prepared, which has, prevents and/or treat
The effect of myopia, amblyopia, quick, significant effect, and safety is without side-effects；(2) prevention provided by the invention is near-sighted, amblyopia
The preparation method of pharmaceutical composition is simple, easy to use, has good commercial promise.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obviously, or practice through the invention is recognized.
Specific implementation mode
Below in conjunction with the embodiment of the present invention, technical scheme of the present invention is clearly and completely described.Implement below
Example is only used for clearly illustrating technical scheme of the present invention, therefore be intended only as example, and cannot limit this hair with this
Bright protection domain.
Experimental method in following embodiments is unless otherwise specified conventional method.Examination as used in the following examples
Material is tested, is to be commercially available from regular shops unless otherwise specified.Quantitative test in following embodiment, is respectively provided with three
Secondary to repeat to test, data are the average value or mean+SD of three repeated experiments.
Cassia seed as used in the following examples, Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary, Poria cocos, the leaf of bamboo, the tuber of pinellia, Radix Salviae Miltiorrhizae, rhizoma imperatae, meat
Desert cistanche, Rhizoma Chuanxiong, the root of bidentate achyranthes, HERBA ANDROGRAPHITID, Moschus, caulis trachelospermi, Longstamen Onion Bulb, Herba Lycopi, agalloch eaglewood and inular flower are meeting Chinese Pharmacopoeia one just
Pertinent regulations under each medicinal material item of text.Before feeding intake, by identification, ingredients material object is consistent with title, and quality complies with standard.
The present invention provide it is a kind of prevention myopia, amblyopia pharmaceutical composition, raw material components by weight, including：Borneol
10~20 parts by weight, 5~7 parts by weight of peppermint, 2~4 parts by weight of cassia seed, 5~10 parts by weight of Radix Paeoniae Alba, 15~20 weight of Fructus Forsythiae
Part, 10~15 parts by weight of curcuma zedoary, 5~10 parts by weight of Poria cocos, 6~10 parts by weight of the leaf of bamboo, 12~20 parts by weight of the tuber of pinellia, Radix Salviae Miltiorrhizae 6~8
Parts by weight, 10~14 parts by weight of rhizoma imperatae, 2~4 parts by weight of Herba Cistanches, 5~7 parts by weight of Rhizoma Chuanxiong, 7~11 parts by weight of the root of bidentate achyranthes, olive
3~6 parts by weight of 12~15 parts by weight of core lotus and Moschus.
Preferably, raw material components further include：6~10 parts by weight of caulis trachelospermi, 3~8 parts by weight of Longstamen Onion Bulb, 2~5 weight of Herba Lycopi
Part, 4~9 parts by weight of 5~10 parts by weight of agalloch eaglewood and inular flower.
In addition, the present invention also provides the preparation method of aforementioned pharmaceutical compositions, include the following steps：By all raw material groups
Divide and mix in proportion, is then ground to the powder that grain size is no more than 0.001mm, obtains pharmaceutical composition.
The present invention also provides another preparation methods of aforementioned pharmaceutical compositions, include the following steps：
Will Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos mix after be added water, after 45~55 DEG C are impregnated 12~14h, adjust pH value to
4.5~4.8, then decoct 40~50min of extraction；After extraction, filtrate is collected in filtering；Wherein, Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and
The ratio of the gross mass of Poria cocos and the quality of water is 1:(10~15)；
Filtrate is dried, other surplus stock components are then added, then is ground into the powder that grain size is no more than 0.001mm,
Obtain pharmaceutical composition.
Technical solution provided by the invention is described further with reference to specific embodiment.
Embodiment one
The present embodiment provides it is a kind of prevention myopia, amblyopia pharmaceutical composition, raw material components by weight, including：Ice
15 parts by weight of piece, 6 parts by weight of peppermint, 3 parts by weight of cassia seed, 7 parts by weight of Radix Paeoniae Alba, 16 parts by weight of Fructus Forsythiae, 12 parts by weight of curcuma zedoary, Fu
8 parts by weight of Siberian cocklebur, 8 parts by weight of the leaf of bamboo, 16 parts by weight of the tuber of pinellia, 7 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of rhizoma imperatae, 3 parts by weight of Herba Cistanches,
6 parts by weight of Rhizoma Chuanxiong, 4 parts by weight of 9 parts by weight of the root of bidentate achyranthes, 14 parts by weight of HERBA ANDROGRAPHITID and Moschus.
Pharmaceutical composition is prepared using preparation method provided by the invention by above-mentioned raw material：
Water is added after Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos are mixed, after 50 DEG C are impregnated 13h, adjusts pH value to 4.6, then decocts
Boil extraction 45min；After extraction, filtrate is collected in filtering；Wherein, the gross mass of Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos and water
The ratio of quality is 1:12；
Filtrate is dried, other surplus stock components are then added, then is ground into the powder that grain size is no more than 0.001mm,
Obtain pharmaceutical composition.
Embodiment two
The present embodiment provides it is a kind of prevention myopia, amblyopia pharmaceutical composition, raw material components by weight, including：Ice
15 parts by weight of piece, 6 parts by weight of peppermint, 3 parts by weight of cassia seed, 7 parts by weight of Radix Paeoniae Alba, 16 parts by weight of Fructus Forsythiae, 12 parts by weight of curcuma zedoary, Fu
8 parts by weight of Siberian cocklebur, 8 parts by weight of the leaf of bamboo, 16 parts by weight of the tuber of pinellia, 7 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of rhizoma imperatae, 3 parts by weight of Herba Cistanches,
6 parts by weight of Rhizoma Chuanxiong, 9 parts by weight of the root of bidentate achyranthes, 14 parts by weight of HERBA ANDROGRAPHITID, 4 parts by weight of Moschus, 8 parts by weight of caulis trachelospermi, 5 parts by weight of Longstamen Onion Bulb,
6 parts by weight of 3 parts by weight of Herba Lycopi, 7 parts by weight of agalloch eaglewood and inular flower.
Pharmaceutical composition is prepared using preparation method provided by the invention by above-mentioned raw material：
Water is added after Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos are mixed, after 50 DEG C are impregnated 13h, adjusts pH value to 4.6, then decocts
Boil extraction 45min；After extraction, filtrate is collected in filtering；Wherein, the gross mass of Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos and water
The ratio of quality is 1:12；
Filtrate is dried, other surplus stock components are then added, then is ground into the powder that grain size is no more than 0.001mm,
Obtain pharmaceutical composition.
Embodiment three
The present embodiment provides it is a kind of prevention myopia, amblyopia pharmaceutical composition, raw material components by weight, including：Ice
10 parts by weight of piece, 7 parts by weight of peppermint, 2 parts by weight of cassia seed, 5 parts by weight of Radix Paeoniae Alba, 20 parts by weight of Fructus Forsythiae, 10 parts by weight of curcuma zedoary, Fu
10 parts by weight of Siberian cocklebur, 6 parts by weight of the leaf of bamboo, 20 parts by weight of the tuber of pinellia, 6 parts by weight of Radix Salviae Miltiorrhizae, 14 parts by weight of rhizoma imperatae, 2 parts by weight of Herba Cistanches,
7 parts by weight of Rhizoma Chuanxiong, 7 parts by weight of the root of bidentate achyranthes, 15 parts by weight of HERBA ANDROGRAPHITID, 3 parts by weight of Moschus, 10 parts by weight of caulis trachelospermi, 3 weight of Longstamen Onion Bulb
Part, 9 parts by weight of 5 parts by weight of Herba Lycopi, 5 parts by weight of agalloch eaglewood and inular flower.
Pharmaceutical composition is prepared using preparation method provided by the invention by above-mentioned raw material：
Water is added after Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos are mixed, after 45 DEG C are impregnated 12h, adjusts pH value to 4.5, then decocts
Boil extraction 40min；After extraction, filtrate is collected in filtering；Wherein, the gross mass of Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos and water
The ratio of quality is 1:10；
Filtrate is dried, other surplus stock components are then added, then is ground into the powder that grain size is no more than 0.001mm,
Obtain pharmaceutical composition.
Example IV
The present embodiment provides it is a kind of prevention myopia, amblyopia pharmaceutical composition, raw material components by weight, including：Ice
20 parts by weight of piece, 5 parts by weight of peppermint, 4 parts by weight of cassia seed, 10 parts by weight of Radix Paeoniae Alba, 15 parts by weight of Fructus Forsythiae, 15 parts by weight of curcuma zedoary,
5 parts by weight of Poria cocos, 10 parts by weight of the leaf of bamboo, 12 parts by weight of the tuber of pinellia, 8 parts by weight of Radix Salviae Miltiorrhizae, 10 parts by weight of rhizoma imperatae, 4 weight of Herba Cistanches
Part, 5 parts by weight of Rhizoma Chuanxiong, 11 parts by weight of the root of bidentate achyranthes, 12 parts by weight of HERBA ANDROGRAPHITID, 6 parts by weight of Moschus, 6 parts by weight of caulis trachelospermi, 8 weight of Longstamen Onion Bulb
Measure part, 4 parts by weight of 2 parts by weight of Herba Lycopi, 10 parts by weight of agalloch eaglewood and inular flower.
Pharmaceutical composition is prepared using preparation method provided by the invention by above-mentioned raw material：
Water is added after Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos are mixed, after 55 DEG C are impregnated 14h, adjusts pH value to 4.8, then decocts
Boil extraction 50min；After extraction, filtrate is collected in filtering；Wherein, the gross mass of Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos and water
The ratio of quality is 1:15；
Filtrate is dried, other surplus stock components are then added, then is ground into the powder that grain size is no more than 0.001mm,
Obtain pharmaceutical composition.
Embodiment five
The present embodiment provides it is a kind of prevention myopia, amblyopia pharmaceutical composition, raw material components by weight, including：Ice
15 parts by weight of piece, 6 parts by weight of peppermint, 3 parts by weight of cassia seed, 7 parts by weight of Radix Paeoniae Alba, 16 parts by weight of Fructus Forsythiae, 12 parts by weight of curcuma zedoary, Fu
8 parts by weight of Siberian cocklebur, 8 parts by weight of the leaf of bamboo, 16 parts by weight of the tuber of pinellia, 7 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of rhizoma imperatae, 3 parts by weight of Herba Cistanches,
6 parts by weight of Rhizoma Chuanxiong, 9 parts by weight of the root of bidentate achyranthes, 14 parts by weight of HERBA ANDROGRAPHITID, 4 parts by weight of Moschus, 8 parts by weight of caulis trachelospermi, 5 parts by weight of Longstamen Onion Bulb,
6 parts by weight of 3 parts by weight of Herba Lycopi, 7 parts by weight of agalloch eaglewood and inular flower.
Pharmaceutical composition is prepared using preparation method provided by the invention by above-mentioned raw material：
All raw material components are mixed in proportion, the powder that grain size is no more than 0.001mm is then ground to, obtains medicine group
Close object.
Comparative example one
This comparative example provide it is a kind of prevention myopia, amblyopia pharmaceutical composition, raw material components by weight, including：Ice
15 parts by weight of piece, 6 parts by weight of peppermint, 3 parts by weight of cassia seed, 7 parts by weight of Radix Paeoniae Alba, 16 parts by weight of Fructus Forsythiae, 12 parts by weight of curcuma zedoary, Fu
8 parts by weight of Siberian cocklebur, 8 parts by weight of the leaf of bamboo, 16 parts by weight of the tuber of pinellia, 7 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of rhizoma imperatae, 3 parts by weight of Herba Cistanches,
6 parts by weight of Rhizoma Chuanxiong, 9 parts by weight of the root of bidentate achyranthes, 8 parts by weight of caulis trachelospermi, 5 parts by weight of Longstamen Onion Bulb, 3 parts by weight of Herba Lycopi, 7 parts by weight of agalloch eaglewood and rotation
6 parts by weight are spent again.
By above-mentioned raw material, pharmaceutical composition is prepared：
Water is added after Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos are mixed, after 50 DEG C are impregnated 13h, adjusts pH value to 4.6, then decocts
Boil extraction 45min；After extraction, filtrate is collected in filtering；Wherein, the gross mass of Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos and water
The ratio of quality is 1:12；
Filtrate is dried, other surplus stock components are then added, then is ground into the powder that grain size is no more than 0.001mm,
Obtain pharmaceutical composition.
Comparative example two
This comparative example provide it is a kind of prevention myopia, amblyopia pharmaceutical composition, raw material components by weight, including：Ice
15 parts by weight of piece, 6 parts by weight of peppermint, 3 parts by weight of cassia seed, 7 parts by weight of Radix Paeoniae Alba, 16 parts by weight of Fructus Forsythiae, 12 parts by weight of curcuma zedoary, Fu
8 parts by weight of Siberian cocklebur, 8 parts by weight of the leaf of bamboo, 16 parts by weight of the tuber of pinellia, 7 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of rhizoma imperatae, 3 parts by weight of Herba Cistanches,
6 parts by weight of Rhizoma Chuanxiong, 9 parts by weight of the root of bidentate achyranthes, 14 parts by weight of HERBA ANDROGRAPHITID, 4 parts by weight of Moschus, 8 parts by weight of caulis trachelospermi, 5 parts by weight of Longstamen Onion Bulb,
6 parts by weight of 3 parts by weight of Herba Lycopi, 7 parts by weight of agalloch eaglewood and inular flower.
By above-mentioned raw material, pharmaceutical composition is prepared：
Water is added after Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos are mixed, after 50 DEG C are impregnated 13h, then decocts extraction 45min；It carries
After taking, filtrate is collected in filtering；Wherein, the ratio of the quality of the gross mass and water of Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos is 1:
12；
Filtrate is dried, other surplus stock components are then added, then is ground into the powder that grain size is no more than 0.001mm,
Obtain pharmaceutical composition.
The pharmaceutical composition that the embodiment of the present invention one is prepared to embodiment five, by clinical test come system evaluation
Its effect, and the pharmaceutical composition being prepared with comparative example one and comparative example two is as a contrast.
1, to A nearsighted person the effect of
Method：350 A nearsighted persons's (12~40 years old age) are recruited, patient passes through physical examination chemical examination and is diagnosed as near-sighted trouble
Person.All patients are divided into 7 groups, every group of 50 A nearsighted persons allow first group to the 5th group of patient to use embodiment respectively
One pharmaceutical composition being prepared to embodiment five allows the 6th group and the 7th group of patient to use comparative example one of the present invention respectively
The pharmaceutical composition being prepared with comparative example two, when use are that pharmaceutical composition is put into the happy mesh instrument of dredging collateral, by stifling
The active constituent in pharmaceutical composition is set to directly act on eye, the time acted on every time is 30min.Continuous use 15 days, is examined
Disconnected curative effect.
Curative effect determinate standard：It cures：Fine work 1 hour or more, eye conditions and whole body can be adhered to reading or watch attentively
Symptom disappearance person；It is effective：It can adhere to reading or watch attentively fine work that (transience hypopsia person, severe were closed in 30~60 minutes
Vision restoration, slight and moderate disease are lost after ten minutes for mesh rest), eye symptom and constitutional symptom respectively have 2 persons of being obviously improved；Have
Effect：It reads or watches attentively before fine work is relatively treated and extend 10 minutes above (transience hypopsia person, severe close mesh and rest 20
Vision restoration after minute, severe close mesh rest vision restoration after ten minutes, and slight disease is lost), eye symptom and constitutional symptom respectively have 2
The item person of being obviously improved, or respectively have the person of being obviously improved；In vain：Pretherapy and post-treatment eye symptom and constitutional symptom are without improver.
As a result：The treatment of each group patient is as shown in table 1 below.
The effect of 1 each group patient of table situation
| Group | It cures (example) | Effective (example) | Effectively (example) | (example) in vain |
| Embodiment one | 15 | 20 | 13 | 2 |
| Embodiment two | 46 | 4 | 0 | 0 |
| Embodiment three | 42 | 7 | 1 | 0 |
| Example IV | 45 | 4 | 1 | 0 |
| Embodiment five | 36 | 12 | 2 | 0 |
| Comparative example one | 21 | 13 | 8 | 8 |
| Comparative example two | 33 | 10 | 7 | 0 |
2, model case
(1) Lee, girl, 15 years old, Jiangxi high school student, blurred vision at the beginning of 2 months in 2015, eye distending pain and eye filled
Blood, it is apathetic, it is absent minded, it is easy to feel sleepy.The pharmaceutical composition being prepared afterwards using the embodiment of the present invention two, is made
Used time is that pharmaceutical composition is put into the happy mesh instrument of dredging collateral, so that the active constituent in pharmaceutical composition is directly acted on by stifling
Eye, the time acted on every time are 30min.After continuous treatment two weeks, memory, vision restoration are discontinued, do not recur so far.
(2) Zhang, male, 30 years old, IT engineer, uncorrected visual acuity 0.5, eye fatigue cannot alleviate for a long time, eye distending pain
And eye is congested, occurs headache, nausea when serious, seriously affects work.The medicine being prepared afterwards using the embodiment of the present invention two
Compositions, when use are that pharmaceutical composition is put into the happy mesh instrument of dredging collateral, by the stifling activity made in pharmaceutical composition at
Divide and directly act on eye, the time acted on every time is 30min.After continuous treatment two weeks, vision restoration is normal, normal work
10~12 as a child, is not in a distending pain phenomenon, and uncorrected visual acuity is promoted to 0.7；Be discontinued, after 3 years follow-up do not recur.
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, it otherwise illustrates in these embodiments
Component and opposite step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely illustrative, not as limitation, because
This, other examples of exemplary embodiment can have different values.
In the description of the present invention, it is to be understood that, term " first ", " second " are used for description purposes only, and cannot
It is interpreted as indicating or implies relative importance or implicitly indicate the quantity of indicated technical characteristic.Define as a result, " the
One ", the feature of " second " can explicitly or implicitly include one or more this feature.In the description of the present invention,
The meaning of " plurality " is two or more, unless otherwise specifically defined.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme should all cover in protection scope of the present invention.
Claims (10)
1. it is a kind of prevention myopia, amblyopia pharmaceutical composition, which is characterized in that raw material components by weight, including：
10~20 parts by weight of borneol, 5~7 parts by weight of peppermint, 2~4 parts by weight of cassia seed, 5~10 parts by weight of Radix Paeoniae Alba, Fructus Forsythiae 15~
20 parts by weight, 10~15 parts by weight of curcuma zedoary, 5~10 parts by weight of Poria cocos, 6~10 parts by weight of the leaf of bamboo, 12~20 parts by weight of the tuber of pinellia, pellet
Join 6~8 parts by weight, 10~14 parts by weight of rhizoma imperatae, 2~4 parts by weight of Herba Cistanches, 5~7 parts by weight of Rhizoma Chuanxiong, 7~11 weight of the root of bidentate achyranthes
Part, 3~6 parts by weight of 12~15 parts by weight of HERBA ANDROGRAPHITID and Moschus.
2. prevention myopia according to claim 1, the pharmaceutical composition of amblyopia, which is characterized in that raw material components further include：
6~10 parts by weight of caulis trachelospermi, 3~8 parts by weight of Longstamen Onion Bulb, 2~5 parts by weight of Herba Lycopi, 5~10 parts by weight of agalloch eaglewood and inular flower 4
~9 parts by weight.
3. prevention myopia according to claim 2, the pharmaceutical composition of amblyopia, which is characterized in that raw material components are by weight
Part meter, including：
15 parts by weight of borneol, 6 parts by weight of peppermint, 3 parts by weight of cassia seed, 7 parts by weight of Radix Paeoniae Alba, 16 parts by weight of Fructus Forsythiae, 12 weight of curcuma zedoary
Measure part, 8 parts by weight of Poria cocos, 8 parts by weight of the leaf of bamboo, 16 parts by weight of the tuber of pinellia, 7 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of rhizoma imperatae, Herba Cistanches 3
Parts by weight, 6 parts by weight of Rhizoma Chuanxiong, 9 parts by weight of the root of bidentate achyranthes, 14 parts by weight of HERBA ANDROGRAPHITID, 4 parts by weight of Moschus, 8 parts by weight of caulis trachelospermi, Longstamen Onion Bulb 5
Parts by weight, 6 parts by weight of 3 parts by weight of Herba Lycopi, 7 parts by weight of agalloch eaglewood and inular flower.
4. claim 1-3 any one of them prevention myopia, the preparation method of the pharmaceutical composition of amblyopia, which is characterized in that
Including step：
All raw material components are mixed in proportion, are then ground to powder, obtain described pharmaceutical composition.
5. prevention myopia according to claim 4, the preparation method of the pharmaceutical composition of amblyopia, it is characterised in that：
The grain size of the powder is no more than 0.001mm.
6. claim 1-3 any one of them prevention myopia, the preparation method of the pharmaceutical composition of amblyopia, which is characterized in that
Including step：
Water is added after Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos are mixed, after impregnating preset time, adjusts pH value to 4.5~4.8, then
Carry out decoction extraction；After extraction, filtrate is collected in filtering；
The filtrate is dried, other surplus stock components, then grind into powder is then added, obtains described pharmaceutical composition.
7. prevention myopia according to claim 6, the preparation method of the pharmaceutical composition of amblyopia, it is characterised in that：
The Radix Paeoniae Alba, Fructus Forsythiae, curcuma zedoary and Poria cocos gross mass and water quality ratio be 1:(10~15).
8. prevention myopia according to claim 6, the preparation method of the pharmaceutical composition of amblyopia, it is characterised in that：
The temperature of the immersion is 45~55 DEG C, and the time of the immersion is 12~14h；It is described decoct extraction time be 40~
50min。
9. prevention myopia according to claim 6, the preparation method of the pharmaceutical composition of amblyopia, it is characterised in that：
The grain size of the powder is no more than 0.001mm.
10. claim 1-3 any one of them pharmaceutical composition prepare prevent and/or treatment myopia, amblyopia drug and/
Or the application in medicated premix.
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