CN108379519A - A kind of drug and preparation method thereof for treating nasopharyngeal carcinoma - Google Patents

A kind of drug and preparation method thereof for treating nasopharyngeal carcinoma Download PDF

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CN108379519A
CN108379519A CN201810511142.2A CN201810511142A CN108379519A CN 108379519 A CN108379519 A CN 108379519A CN 201810511142 A CN201810511142 A CN 201810511142A CN 108379519 A CN108379519 A CN 108379519A
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张永红
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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Abstract

The invention discloses a kind of drugs and preparation method thereof for treating nasopharyngeal carcinoma, it is mainly by oldenlandia diffusa, earthworm, Radix Curcumae, Centipeda minima, Lasiosphaera fenzlii, radix pseudostellariae, honeysuckle, lucid asparagus, radix polygonati officinalis, the stem of noble dendrobium, tinosporae, Sculellaria barbata, uncaria, madder, rhizoma imperatae, peach kernel, the achene of Siberian cocklebur, Fructus Forsythiae, blackberry lily, scorpio, Prunella vulgaris, field thistle, the root bark of Chinese wolf-berry, Semen Cuscutae, fructus viticis, rhizoma atractylodis, rhizoma anemarrhenae is prepared according to a certain weight ratio, drug of the present invention has clearing heat and promoting diuresis, removing toxic substances, cool blood broken stasis of blood, dredge stuffy nose, promoting the circulation of qi solution with, promote the production of body fluid beneficial stomach, the function of dissolving phlegm, it is quick for treating nasopharyngeal carcinoma, good effect, it does not recur.

Description

A kind of drug and preparation method thereof for treating nasopharyngeal carcinoma
Technical field
The present invention relates to a kind of drugs and preparation method thereof for treating nasopharyngeal carcinoma, belong to the field of Chinese medicines.
Technical background
Nasopharyngeal carcinoma refers to the malignant tumour betided at the top of nasopharyngeal cavity with side wall.It is one of China's malignant tumour occurred frequently, hair Sick rate is first of ear,nose ＆ throat malignant tumour.Chinese medicine then thinks that nasopharyngeal carcinoma stops up Sheng, qi and blood cohesion, the turbid accumulation of phlegm, body fluid deficiency with heat toxin It is impairment of yin, weakness of the spleen and the stomach related.Since western medicine side effect is big, there is the Chinese medicine for effectively treating nasopharyngeal carcinoma in people Great demand, up to now, it has not been found that the related report about the present invention.
Invention content
The present inventor is on the basis of secret prescription handed down in the family from generation to generation, and the verification repeatedly Jing Guo clinical test, has finally found and effectively controls The drug of nasopharyngeal carcinoma is treated, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine compositions of effective treatment nasopharyngeal carcinoma.
Another aim of the present invention is to provide the preparation methods of the Chinese medicine composition.
The present invention be selection oldenlandia diffusa, earthworm, Radix Curcumae, Centipeda minima, Lasiosphaera fenzlii, radix pseudostellariae, honeysuckle, lucid asparagus, It is radix polygonati officinalis, the stem of noble dendrobium, tinosporae, Sculellaria barbata, uncaria, madder, rhizoma imperatae, peach kernel, the achene of Siberian cocklebur, Fructus Forsythiae, blackberry lily, scorpio, Prunella vulgaris, small Ji, the root bark of Chinese wolf-berry, Semen Cuscutae, fructus viticis, rhizoma atractylodis, rhizoma anemarrhenae, the flower bud of lily magnolia, moutan bark, oyster, Radix Rehmanniae drug are combined preparation, will These pharmaceutical compositions make each efficacy of drugs generate synergistic effect, so as to effectively treat nasopharyngeal carcinoma.Wherein, long-noded pit viper is selected Tongue grass is trembled with fear because of its nature and flavor bitter sweet, is entered the heart, liver, spleen three and is passed through, has heat-clearing, dampness removing, the function of removing toxic substances to control dyspnea and cough due to lung-heat, almond Body is scorching, sphagitis, appendicitis, dysentery, jaundice, pelvic infecton, adnexitis, carbuncle swells furunculosis, venomous snake bite.It is because of it to select earthworm Nature and flavor are salty, tremble with fear, enter liver, spleen, lung channel, there is a heat-clearing, soothing the liver, Zhichuan, the function of dredging collateral, and it is manic to control high fever, convulsion, wind-heat head Bitterly, hot eyes, apoplexy and hemiplegia are panted, larynx numbness, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, sore.Select Radix Curcumae It is to work hard because of its nature and flavor, it is cool, enter the heart, lung, Liver Channel, has promoting the circulation of qi solution with the function of cool blood broken stasis of blood controls all pains of chest and abdomen side of body rib, loses The heart is demented, pyreticosis coma, spits blood, bleeding from five sense organs or subcutaneous tissue, hematuria, blood strangury, women's vicarious menstruation, jaundice.Select Centipeda minima be because its nature and flavor it is pungent, Temperature enters meridian of Hand-TAI YIN qi leel, there is wind-dispelling, and cold dispelling, victory is wet, and screen, the function of dredge stuffy nose is gone to cure cold, and trembles with fear and roars, larynx numbness, pertussis, Eruptive disease abdominal pain, amebic dysentery, malaria, infantile malnutrition due to digestive disturbances or intestinalparasites are rushed down, nasosinusitis, polyp, and mesh screen is puckery to itch, ulcer on the shank, mange, bruise.Select Lasiosphaera fenzlii be because Its nature and flavor is pungent, puts down.Enter lung channel.Removing heat from the lung and relieving sorethroat detoxifies, hemostasis.Larynx numbness pharyngalgia is controlled, cough with aphonia spits blood, bleeding from five sense organs or subcutaneous tissue, traumatic hemorrhage. It is the tepor because of its nature and flavor sweetness and bitterness to select radix pseudostellariae, enters the heart, spleen, lung three and passes through, has tonifying lung, the function of invigorating the spleen, control cough due to deficiency of the lung, Spleen eating less, palpitaition mesh sweat, metal fatigue.It is to tremble with fear because its nature and flavor is sweet, enter lung, stomach, there is heat-clearing, detoxify to select honeysuckle Function, control warm disease heating, toxic-heat and blood stasis, large carbuncle, pyogenic infections, scrofula, anal fistula.Selecting lucid asparagus is trembled with fear because of its nature and flavor sweetness and bitterness, Entering lung, kidney channel, there is enriching yin, moisturizes, clearing lung-heat, the function of fall fire controls fever due to yin deficiency, and cough is spitted blood, consumptive lung disease, lung carbuncle, abscess of throat, It quenches one's thirst, constipation.It is to enter lung, stomach has yin-nourishing, moisturizes, relieving restlessness, and the function of quenching the thirst is controlled because of its nature and flavor sweet and neutral to select radix polygonati officinalis Pyreticosis sun is hindered, and cough, polydipsia, deficient fever, the paddy that disappears is easily hungry, frequent urination.Select the stem of noble dendrobium be because its property slightly sweet flavor it is micro- salty, It is cold, enter to have, lung, kidney channel, there is the beneficial stomach that promotes the production of body fluid, the function of clearing heat and nourishing yin to control consumption of body fluid caused by febrile disease, dry is tired to drink, after being ill abnormal heat, impairment of yin mesh Secretly.It is to tremble with fear because its is bitter in taste, enter spleen, kidney two warp to select tinosporae, there is a clearing heat and detoxicating function, treating acute and chronic tonsillitis, Acute laryngopharyngitis, stomatitis, parotitis, mastitis, appendicitis, ulcer boils, acute chronic enteritis, bacillary dysentery, stomachache, heat are coughed mistake Sound.Select Sculellaria barbata be because its nature and flavor it is pungent, bitter, it is cold in nature.Distributed in lung channel, Liver Channel, kidney channel have clearing heat and detoxicating, promoting blood circulation and removing blood stasis, diuresis Function, for treating advanced schistosomiasis ascites, cirrhotic ascites, venomous snake bite, boil carbuncle swells.It is because of it to select uncaria It is bitter in taste, it is cool, enter liver, the heart channel of Hang-Shaoyin, there is The flat liver of heat-clearing, the function for the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. controls little Jing Epilepsy Chi Zong, adult's slight Hypertension, head Dizzy, dizzy, married woman's sub- Epilepsy.It is to tremble with fear because its is bitter in taste, have cooling blood and hemostasis, the function of Stasis through to control haematemesis to select madder, Bleeding from five sense organs or subcutaneous tissue, uterine bleeding, traumatic hemorrhage, stasis blocking Amenorrhea, joint pain, tumbling and swelling.Selecting rhizoma imperatae is entered because its nature and flavor is sweet, cold Lung, stomach, small intestinl channel have cool blood, and hemostasis, heat-clearing, the function of diuresis controls pyreticosis polydipsia, spit blood, bleeding from five sense organs or subcutaneous tissue, and lung heat asthma is anxious, the stomach energy sound of vomiting It is inverse, gonorrhoea, difficult urination, oedema, jaundice.It is to enter the heart, liver, large intestine channel because of its sweet and neutral bitter in taste, there is blood-breaking to select peach kernel The row stasis of blood, moisturizes the function of sliding warp, controlling through closing , Disorder lumps in the abdomen, and pyreticosis stores blood, blood-arthralgia, malaria, traumatic injury, blood stasis and swelling pain, and blood is dry just It is secret.Select the achene of Siberian cocklebur be because of its nature and flavor sweet, warm, it is toxic, enter lung, Liver Channel, there is relieve heat, relieve pain, clearing damp, the function of desinsection is controlled Anemofrigid headache, nasosinusitis, dentalgia, wind-cold-dampness arthralgia, four foot contraction pains, scabies leprosy, itch.Select Fructus Forsythiae be because its is bitter in taste, it is cool, enter The heart, liver, gallbladder channel have heat-clearing, and removing toxic substances, dissipating bind, the function of detumescence controls warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching It closes.Selecting blackberry lily is trembled with fear because its is bitter in taste, toxic, enters lung, Liver Channel, there is fall fire, detoxify, dissipate blood, the function of dissolving phlegm controls larynx Numbness pharyngalgia, cough with dyspnea, accumulation and obstruction of sputum, scrofula tuberculosis, malaria with abdominal mass, women's Amenorrhea, carbuncle sore tumefacting virus.It is because of its nature and flavor to select scorpio It is salty pungent, it puts down, it is toxic, enter meridian of Foot-JUE YIN, there is a wind-dispelling, relieving convulsion, dredging collateral, the function of removing toxic substances controls convulsion , Dian Epilepsy, apoplexy, half body Unsuccessful, deviation of the eye and mouth, migraine, arthralgia pain due to rheumatism, lockjaw, scrofula, rubella sore swells.It is because of its property to select Prunella vulgaris It is bitterly, it trembles with fear, enters liver, gallbladder channel, there is clearing liver, the function of dissipating bind to control scrofula, goiter and tumor, acute mastitis, breast cancer, mesh pearl nyctalgia, photophobia stream Tear, vertigo, facial paralysis, arthralgia and myalgia, pulmonary tuberculosis, acute icteric catarrhal jaundice, metrorrhagia, under.Select field thistle It is to enter spleen, the warp of stomach two because its nature and flavor is acrid in flavour and warm in nature, have middle benefit gas, lower gas, disappear paddy, the function of desinsection, controls vomiting and diarrhoea, trusted subordinate's distending pain, malignant boil Pyogenic infections sore, poisonous insect flood dragon wound.It is to tremble with fear because its nature and flavor is sweet, enter lung, liver and kidney channel, have heat-clearing, the function of cool blood to control to select the root bark of Chinese wolf-berry Consumptive disease hectic fever night sweat, lung heat cough and asthma are spitted blood, and bleeding from five sense organs or subcutaneous tissue, blood strangury is quenched one's thirst, hypertension, carbuncle swells, malignant sore.It is because of it to select Semen Cuscutae The pungent sweet and neutral of nature and flavor, enters liver and kidney channel, has filling liver kidney, benefiting quintessence, the function of improving eyesight to control soreness of waist and knee joint, and seminal emission is quenched one's thirst, urine is had a surplus Drip, mesh are dark.Select fructus viticis be because of its nature and flavor toil, it is cool, enter liver, stomach, bladder warp has dispelling wind and heat from the body, the work(of head clearing Can, anemopyretic cold is controlled, just, migraine, dentalgia, pain in mesh eyeball.It is because its nature and flavor is arduous to select rhizoma atractylodis, and temperature enters spleen, stomach, There are invigorating the spleen, eliminating dampness, Xie Yu to ward off dirty function, controls wet soreness, burnout, gastral cavity ruffian abdominal distension is lost the appetite, vomiting, diarrhea, Dysentery, malaria, phlegm and retained fluid, oedema, feel cold, wind-cold-dampness arthralgia, atrophy, yctalopia.Selecting rhizoma anemarrhenae is trembled with fear, enters because its is bitter in taste Lung, stomach, kidney channel have nourishing yin and lessening fire, the function of moisturize laxation to control dysphoria with smothery sensation and quench one's thirst, hectic fever due to yin labor heat, cough with lung heat, and dry feces are small Just unfavorable.It is to enter lung, stomach because its nature and flavor is acrid in flavour and warm in nature to select the flower bud of lily magnolia, has wind-dispelling, sensible function to control headache, nasosinusitis, nasal obstruction It is obstructed, dentalgia.Selecting moutan bark is worked hard because of its nature and flavor, cool, enters the heart, liver and kidney channel, there is heat-clearing, cool blood and blood, dispersing blood stasis Function controls heat invading xuefen, and macular eruption , Jing Epilepsy is spat, is defeated in battle, has blood in stool, and hectic fever due to yin labor heat, Amenorrhea , Disorder lumps in the abdomen, large carbuncle flutters damage.Selecting oyster is Because its nature and flavor is salty and bitter, cool, enter liver and kidney channel, hold back the moon, checking exuberance of yang, hidroschesis, puckery essence, resolving sputum, the function of softening hard masses, Zhi Jing Epilepsy is dizzy It is dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, uterine bleeding, under, scrofula, goiter and tumor.Select Radix Rehmanniae be because its nature and flavor it is sweet, tremble with fear, the thoughts of returning home, liver, Kidney channel has clearing heat and cooling blood, yin-nourishing, the function of promoting the production of body fluid to control pyreticosis polydipsia, yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, Heat Diabetes, haematemesis, nosebleed Blood, spot dermexanthesis.
Specific implementation mode
The drug dose of instant component is also to be obtained by plenty of explorations of the inventor, and the dosage of each component is following heavy All tools have a better effect in amount range：
20-30 grams of oldenlandia diffusa, 10-20 grams of earthworm, 10-20 grams of Radix Curcumae, 15-20 grams of Centipeda minima, 10-15 grams of Lasiosphaera fenzlii, too Son ginseng 5-15 grams, 10-15 grams of honeysuckle, 10-15 grams of lucid asparagus, 5-15 grams of radix polygonati officinalis, 10-20 grams of the stem of noble dendrobium, 10-20 grams of tinosporae, 5-15 grams of Sculellaria barbata, 5-10 grams of madder, 10-15 grams of rhizoma imperatae, 10-15 grams of peach kernel, 5-15 grams of the achene of Siberian cocklebur, connects 5-15 grams of uncaria Stick up 5-15 grams, 10-15 grams of blackberry lily, 5-15 grams of scorpio, 5-10 grams of Prunella vulgaris, 5-15 grams of field thistle, 10-20 grams of the root bark of Chinese wolf-berry, Semen Cuscutae 10-15 grams, 3-9 grams of fructus viticis, 10-15 grams of rhizoma atractylodis, 5-15 grams of rhizoma anemarrhenae, 10-15 grams of the flower bud of lily magnolia, 5-15 grams of moutan bark, oyster 10-20 Gram, 5-15 grams of Radix Rehmanniae.
Preferably：
25 grams of oldenlandia diffusa, 15 grams of earthworm, 15 grams of Radix Curcumae, 18 grams of Centipeda minima, 12 grams of Lasiosphaera fenzlii, 10 grams of radix pseudostellariae, honeysuckle 12 grams, 12 grams of lucid asparagus, 10 grams of radix polygonati officinalis, 15 grams of the stem of noble dendrobium, 15 grams of tinosporae, 10 grams of Sculellaria barbata, 10 grams of uncaria, 8 grams of madder, cogongrass 12 grams of root, 12 grams of peach kernel, 10 grams of the achene of Siberian cocklebur, 10 grams of Fructus Forsythiae, 12 grams of blackberry lily, 10 grams of scorpio, 8 grams of Prunella vulgaris, 10 grams of field thistle, bone 15 grams of skin, 12 grams of Semen Cuscutae, 6 grams of fructus viticis, 12 grams of rhizoma atractylodis, 10 grams of rhizoma anemarrhenae, 12 grams of the flower bud of lily magnolia, 10 grams of moutan bark, 15 grams of oyster, life 10 grams of ground.
The preparation method of drug of the present invention is as follows
One, it stocks up
1, oldenlandia diffusa：Crude drug is taken, impurity is removed, wash quickly is net, slightly dries in the air, segment, dry, weeds out grey bits；
2, earthworm：Impurity is picked, is rinsed with water, is pulled out in time, is dried, segment；
3, Radix Curcumae：It is soaked in water, cleans, pull solarization out and dry in the air, moisturize, be sliced, dry；
4, Centipeda minima：Net impurity is picked, segment is dried；
5, Lasiosphaera fenzlii：Remove sclerderm, dice；
6, radix pseudostellariae：Fibrous root is extractd, is dried；
7, honeysuckle：Silt is weeded out, net impurity is picked；
8, lucid asparagus：Impurity is picked, water is cleaned, bored profit to uniform humidity inside and outside, segment, drying；
9, radix polygonati officinalis：Impurity is removed, soil, bored profit to uniform humidity inside and outside are cleaned, slice dries；
10, the stem of noble dendrobium：The dry stem of noble dendrobium is taken, it is about saturating to eighty per cant with bubble, it stews to moisten, removes undesirable root and film is hit in black branch, segment, It dries；
11, tinosporae：Impurity is removed, is soaked in water, about seventy percent thoroughly, takes out, and waits for that profit to uniform humidity inside and outside, is sliced or is cut into and is small Block dries；
12, Sculellaria barbata：Spring, the harvesting of summer-flowering phase, complete stool of choosing remove silt, dry；
13, uncaria：Old stalk, impurity are picked, cleans, dries；
14, madder：Impurity is removed, is cleaned, is moisturized, cut sheet or section, it is dry, weed out clast；
15, rhizoma imperatae：Net impurity is picked, is cleaned, micro- profit, segment is dried, net clast of winnowing with a dustpan；
16, peach kernel：Hard shell impurity is removed, sets in boiling water pot and boils to crust microcreping, pull out, is immersed in cold water, kind of a skin is removed in stranding, shines It is dry, it winnows with a dustpan net；
17, the achene of Siberian cocklebur：Most impurity is picked, deburring weeds out grey bits, and to yellow, taking-up cools for micro- stir-fry；
18, Fructus Forsythiae：Net impurity is picked, is rubbed open, discarding stalk is removed；
19, blackberry lily：Impurity is picked, water is cleaned, slightly impregnates, pull out, moisturize, and is sliced, dries, and weeds out and must, consider to be worth doing；
20, scorpio：Clear water floats the matter that desalts, and dries or low baking temperature roasting is used；
21, Prunella vulgaris：Crude drug is taken, discarding stalk, blade and impurity is removed, weeds out grey bits；
22, field thistle：Net impurity is picked, root, washing is gone to moisturize, section is dried；
23, the root bark of Chinese wolf-berry：Impurity and core are picked, is slightly washed, segment is dried；
24, Semen Cuscutae：It crosses square-bottomed bamboo basket and removes impurity, clean, dry；
25, fructus viticis：Well sifted ash is considered to be worth doing, is removed remaining sepal, is set in pot and fried with high heat to coke yellow, slightly spray clear water, cool；
26, rhizoma atractylodis：Impurity is picked, thoroughly with bubble to seven, eighty per cant, pulls out, is sliced, dries after moisturizing；
27, rhizoma anemarrhenae：Net impurity is picked, is hit and is washed with water, is pulled out, is softened, slice dries；
28, the flower bud of lily magnolia：Net branch stalk impurity is picked, smashs use to pieces；
29, moutan bark：Impurity is picked, core is removed, cleans, moisturizes, is sliced, dries；
30, oyster：It cleans, dries, pulverize use；
31, Radix Rehmanniae：Crude drug is taken, impurity is removed, is cleaned, is slightly moistened, cut sheet, it is dry, weed out clast.
Two, it prepares
1, by the oldenlandia diffusa of the weight, earthworm, Radix Curcumae, Centipeda minima, Lasiosphaera fenzlii, radix pseudostellariae, honeysuckle, lucid asparagus, jade It is bamboo, the stem of noble dendrobium, tinosporae, Sculellaria barbata, uncaria, madder, rhizoma imperatae, peach kernel, the achene of Siberian cocklebur, Fructus Forsythiae, blackberry lily, scorpio, Prunella vulgaris, small Ji, the root bark of Chinese wolf-berry, Semen Cuscutae, fructus viticis, rhizoma atractylodis, rhizoma anemarrhenae, the flower bud of lily magnolia, moutan bark, oyster, Radix Rehmanniae are put into decocting container, add 8 times of water Amount, after impregnating 100 minutes, high heat decoction boiling, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, it will for the first time Decoction liquor is poured into container；
2, the dregs of a decoction of filtering are added into 6 times of amounts of water, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；
3, it decoction liquor will be mixed evenly twice, and be divided into 3 doses and take.
Oldenlandia diffusa heat-clearing in prescription, dampness removing, removing toxic substances, earthworm have a heat-clearing, soothing the liver, Zhichuan, and both functions of dredging collateral are Monarch drug in a prescription；Radix Curcumae promoting the circulation of qi solution is with, cool blood broken stasis of blood, and Centipeda minima has wind-dispelling, and cold dispelling, victory is wet, goes screen, the function of dredge stuffy nose, with Lasiosphaera fenzlii, Radix pseudostellariae, honeysuckle, lucid asparagus, radix polygonati officinalis be ministerial drug, nine taste medicines play jointly clearing heat and promoting diuresis, removing toxic substances, cool blood broken stasis of blood, dredge stuffy nose, For promoting the circulation of qi solution with the effect of, soothing the liver Zhichuan, treatment nasopharyngeal carcinoma effect is comprehensive, and with clearing heat and promoting diuresis, removing toxic substances, cool blood broken stasis of blood, dredge stuffy nose, Promoting the circulation of qi solution can effect a permanent cure based on；The stem of noble dendrobium has a beneficial stomach that promotes the production of body fluid, the function of clearing heat and nourishing yin and tinosporae, Sculellaria barbata, uncaria, madder, white Lalang grass rhizome, peach kernel, the achene of Siberian cocklebur, Fructus Forsythiae are adjutant；Blackberry lily has fall fire, removing toxic substances, dissipates blood, and the function of dissolving phlegm is to make medicine with remaining all medicines, It is to take stopgap measures.
Drug of the present invention has clearing heat and promoting diuresis, removing toxic substances, cool blood broken stasis of blood, dredge stuffy nose, promoting the circulation of qi solution with, the beneficial stomach that promotes the production of body fluid, dissolving phlegm Function, for treating nasopharyngeal carcinoma, short treating period, quick, non-relapse after healing.
Carry out the advantageous effect of the present invention is further explained the drug below by way of test example, these test examples include this hair The animal toxicity test report of bright drug and clinical observation on the therapeutic effect data.
The animal toxicity test of [test example 1] drug of the present invention is reported：
Rabbit 30, male and female dual-purpose, 2.0-2.5kg of weight is taken to be divided to two groups, every group 15, one of which is tested for overdose Group, another group is normal amount test group.Super quantity group is 20ml/kg, normal amount 10ml/kg, and administering mode gives for administration by gavage Medicine even served 7 days twice daily, the reaction of observation administration daily, the results showed that two groups of rabbit activities, diet are normal, and drug is without bad Toxic side effect.
The clinical observation on the therapeutic effect of [test example 2] drug of the present invention
1, general information
Accept nasopharyngeal carcinoma out-patient totally 43 for medical treatment.
2, diagnostic criteria
Classical symptom is：Band blood, ear muffle block up sense, Hearing, diplopia and headache etc. in nasal obstruction, tears.
3, therapy
Above-mentioned medicament is selected, is taken to patient, each taking 1 dose, early daily, evening respectively takes 1 time, 30 days as a treatment course, continuously It takes 3 course for the treatment of.
4, efficacy assessment standard
It is effective：Nasopharynx cancerous symptom disappears, and restores normal, and follow-up 1 year is without recurrence；
It improves：Band blood, ear muffle are blocked up sense, Hearing, diplopia and are mitigated the phenomenon that headache, nasopharynx cancerous symptom in patient's nasal obstruction, tears It is clearly better, gradually restores normal；
In vain：Improvement standard person is not achieved.
5, treatment results（It see the table below）
In above-mentioned treatment, with drug therapy Nasopharyngeal Carcinoma Patients 43 of the present invention, as a result effective 32, obvious effective rate 74.42%, It improves 7, improvement rate 16.28%, invalid 4, total effective rate 90.7%.

Claims (3)

1. a kind of drug for treating nasopharyngeal carcinoma, it is characterised in that：It is made of the bulk pharmaceutical chemicals in following weight range：
20-30 grams of oldenlandia diffusa, 10-20 grams of earthworm, 10-20 grams of Radix Curcumae, 15-20 grams of Centipeda minima, 10-15 grams of Lasiosphaera fenzlii, too Son ginseng 5-15 grams, 10-15 grams of honeysuckle, 10-15 grams of lucid asparagus, 5-15 grams of radix polygonati officinalis, 10-20 grams of the stem of noble dendrobium, 10-20 grams of tinosporae, 5-15 grams of Sculellaria barbata, 5-10 grams of madder, 10-15 grams of rhizoma imperatae, 10-15 grams of peach kernel, 5-15 grams of the achene of Siberian cocklebur, connects 5-15 grams of uncaria Stick up 5-15 grams, 10-15 grams of blackberry lily, 5-15 grams of scorpio, 5-10 grams of Prunella vulgaris, 5-15 grams of field thistle, 10-20 grams of the root bark of Chinese wolf-berry, Semen Cuscutae 10-15 grams, 3-9 grams of fructus viticis, 10-15 grams of rhizoma atractylodis, 5-15 grams of rhizoma anemarrhenae, 10-15 grams of the flower bud of lily magnolia, 5-15 grams of moutan bark, oyster 10-20 Gram, 5-15 grams of Radix Rehmanniae.
2. drug according to claim 1, wherein the dosage of each bulk pharmaceutical chemicals is：
25 grams of oldenlandia diffusa, 15 grams of earthworm, 15 grams of Radix Curcumae, 18 grams of Centipeda minima, 12 grams of Lasiosphaera fenzlii, 10 grams of radix pseudostellariae, honeysuckle 12 grams, 12 grams of lucid asparagus, 10 grams of radix polygonati officinalis, 15 grams of the stem of noble dendrobium, 15 grams of tinosporae, 10 grams of Sculellaria barbata, 10 grams of uncaria, 8 grams of madder, cogongrass 12 grams of root, 12 grams of peach kernel, 10 grams of the achene of Siberian cocklebur, 10 grams of Fructus Forsythiae, 12 grams of blackberry lily, 10 grams of scorpio, 8 grams of Prunella vulgaris, 10 grams of field thistle, bone 15 grams of skin, 12 grams of Semen Cuscutae, 6 grams of fructus viticis, 12 grams of rhizoma atractylodis, 10 grams of rhizoma anemarrhenae, 12 grams of the flower bud of lily magnolia, 10 grams of moutan bark, 15 grams of oyster, life 10 grams of ground.
3. the preparation method of drug according to claim 1 or claim 2, it includes the following steps：
（One）Stock
（1）Oldenlandia diffusa：Crude drug is taken, impurity is removed, wash quickly is net, slightly dries in the air, segment, dry, weeds out grey bits；
（2）Earthworm：Impurity is picked, is rinsed with water, is pulled out in time, is dried, segment；
（3）Radix Curcumae：It is soaked in water, cleans, pull solarization out and dry in the air, moisturize, be sliced, dry；
（4）Centipeda minima：Net impurity is picked, segment is dried；
（5）Lasiosphaera fenzlii：Remove sclerderm, dice；
（6）Radix pseudostellariae：Fibrous root is extractd, is dried；
（7）Honeysuckle：Silt is weeded out, net impurity is picked；
（8）Lucid asparagus：Impurity is picked, water is cleaned, bored profit to uniform humidity inside and outside, segment, drying；
（9）Radix polygonati officinalis：Impurity is removed, soil, bored profit to uniform humidity inside and outside are cleaned, slice dries；
（10）The stem of noble dendrobium：The dry stem of noble dendrobium is taken, it is about saturating to eighty per cant with bubble, it stews to moisten, removes undesirable root and film is hit in black branch, segment, It dries；
（11）Tinosporae：Impurity is removed, is soaked in water, about seventy percent thoroughly, takes out, and waits for that profit to uniform humidity inside and outside, is sliced or is cut into Fritter dries；
（12）Sculellaria barbata：Spring, the harvesting of summer-flowering phase, complete stool of choosing remove silt, dry；
（13）Uncaria：Old stalk, impurity are picked, cleans, dries；
（14）Madder：Impurity is removed, is cleaned, is moisturized, cut sheet or section, it is dry, weed out clast；
（15）Rhizoma imperatae：Net impurity is picked, is cleaned, micro- profit, segment is dried, net clast of winnowing with a dustpan；
（16）Peach kernel：Hard shell impurity is removed, sets in boiling water pot and boils to crust microcreping, pull out, is immersed in cold water, kind of a skin is removed in stranding, shines It is dry, it winnows with a dustpan net；
（17）The achene of Siberian cocklebur：Most impurity is picked, deburring weeds out grey bits, and to yellow, taking-up cools for micro- stir-fry；
（18）Fructus Forsythiae：Net impurity is picked, is rubbed open, discarding stalk is removed；
（19）Blackberry lily：Impurity is picked, water is cleaned, slightly impregnates, pull out, moisturize, and is sliced, dries, and weeds out and must, consider to be worth doing；
（20）Scorpio：Clear water floats the matter that desalts, and dries or low baking temperature roasting is used；
（21）Prunella vulgaris：Crude drug is taken, discarding stalk, blade and impurity is removed, weeds out grey bits；
（22）Field thistle：Net impurity is picked, root, washing is gone to moisturize, section is dried；
（23）The root bark of Chinese wolf-berry：Impurity and core are picked, is slightly washed, segment is dried；
（24）Semen Cuscutae：It crosses square-bottomed bamboo basket and removes impurity, clean, dry；
（25）Fructus viticis：Well sifted ash is considered to be worth doing, is removed remaining sepal, is set in pot and fried with high heat to coke yellow, slightly spray clear water, cool；
（26）Rhizoma atractylodis：Impurity is picked, thoroughly with bubble to seven, eighty per cant, pulls out, is sliced, dries after moisturizing；
（27）Rhizoma anemarrhenae：Net impurity is picked, is hit and is washed with water, is pulled out, is softened, slice dries；
（28）The flower bud of lily magnolia：Net branch stalk impurity is picked, smashs use to pieces；
（29）Moutan bark：Impurity is picked, core is removed, cleans, moisturizes, is sliced, dries；
（30）Oyster：It cleans, dries, pulverize use；
（31）Radix Rehmanniae：Crude drug is taken, impurity is removed, is cleaned, is slightly moistened, cut sheet, it is dry, weed out clast；
（Two）It prepares
（1）By the oldenlandia diffusa of the weight, earthworm, Radix Curcumae, Centipeda minima, Lasiosphaera fenzlii, radix pseudostellariae, honeysuckle, lucid asparagus, jade It is bamboo, the stem of noble dendrobium, tinosporae, Sculellaria barbata, uncaria, madder, rhizoma imperatae, peach kernel, the achene of Siberian cocklebur, Fructus Forsythiae, blackberry lily, scorpio, Prunella vulgaris, small Ji, the root bark of Chinese wolf-berry, Semen Cuscutae, fructus viticis, rhizoma atractylodis, rhizoma anemarrhenae, the flower bud of lily magnolia, moutan bark, oyster, Radix Rehmanniae are put into decocting container, add 8 times of water Amount, after impregnating 100 minutes, high heat decoction boiling, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, it will for the first time Decoction liquor is poured into container；
（2）The dregs of a decoction of filtering are added into 6 times of amounts of water, are boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；
（3）It decoction liquor will be mixed evenly twice, and be divided into 3 doses and take.
CN201810511142.2A 2018-05-25 2018-05-25 A kind of drug and preparation method thereof for treating nasopharyngeal carcinoma Withdrawn CN108379519A (en)

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Application publication date: 20180810