CN108368155A - 人源性免疫抑制蛋白和肽作为药物的应用 - Google Patents
人源性免疫抑制蛋白和肽作为药物的应用 Download PDFInfo
- Publication number
- CN108368155A CN108368155A CN201680070131.4A CN201680070131A CN108368155A CN 108368155 A CN108368155 A CN 108368155A CN 201680070131 A CN201680070131 A CN 201680070131A CN 108368155 A CN108368155 A CN 108368155A
- Authority
- CN
- China
- Prior art keywords
- amino acid
- polypeptide
- seq
- protein
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 549
- 108090000623 proteins and genes Proteins 0.000 title claims description 262
- 102000004169 proteins and genes Human genes 0.000 title claims description 212
- 239000003814 drug Substances 0.000 title claims description 67
- 229940079593 drug Drugs 0.000 title claims description 51
- 230000006028 immune-suppresssive effect Effects 0.000 title description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 423
- 206010061218 Inflammation Diseases 0.000 claims abstract description 62
- 230000004054 inflammatory process Effects 0.000 claims abstract description 62
- 229920001184 polypeptide Polymers 0.000 claims description 348
- 150000001413 amino acids Chemical class 0.000 claims description 217
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 151
- 201000010099 disease Diseases 0.000 claims description 145
- 150000007523 nucleic acids Chemical class 0.000 claims description 131
- 239000013604 expression vector Substances 0.000 claims description 130
- 102000039446 nucleic acids Human genes 0.000 claims description 125
- 108020004707 nucleic acids Proteins 0.000 claims description 125
- 239000008194 pharmaceutical composition Substances 0.000 claims description 122
- 108090001005 Interleukin-6 Proteins 0.000 claims description 71
- 102000004889 Interleukin-6 Human genes 0.000 claims description 71
- 230000014509 gene expression Effects 0.000 claims description 71
- 208000023275 Autoimmune disease Diseases 0.000 claims description 58
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 49
- 206010003246 arthritis Diseases 0.000 claims description 48
- 238000011282 treatment Methods 0.000 claims description 46
- 239000000203 mixture Substances 0.000 claims description 41
- 230000000694 effects Effects 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 37
- -1 carrier Substances 0.000 claims description 31
- 230000003405 preventing effect Effects 0.000 claims description 31
- 230000006798 recombination Effects 0.000 claims description 31
- 238000005215 recombination Methods 0.000 claims description 30
- 241000700605 Viruses Species 0.000 claims description 29
- 230000002757 inflammatory effect Effects 0.000 claims description 26
- 238000006471 dimerization reaction Methods 0.000 claims description 25
- 206010040047 Sepsis Diseases 0.000 claims description 19
- 239000003085 diluting agent Substances 0.000 claims description 19
- 230000035772 mutation Effects 0.000 claims description 19
- 230000009885 systemic effect Effects 0.000 claims description 17
- 239000000178 monomer Substances 0.000 claims description 16
- 230000001684 chronic effect Effects 0.000 claims description 15
- 239000007924 injection Substances 0.000 claims description 14
- 238000002347 injection Methods 0.000 claims description 14
- 206010020751 Hypersensitivity Diseases 0.000 claims description 13
- 230000001154 acute effect Effects 0.000 claims description 13
- 239000000853 adhesive Substances 0.000 claims description 13
- 230000001070 adhesive effect Effects 0.000 claims description 13
- 208000026935 allergic disease Diseases 0.000 claims description 13
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 13
- 239000002904 solvent Substances 0.000 claims description 13
- 208000006673 asthma Diseases 0.000 claims description 12
- 230000004957 immunoregulator effect Effects 0.000 claims description 12
- 230000002265 prevention Effects 0.000 claims description 12
- 238000002560 therapeutic procedure Methods 0.000 claims description 12
- 239000002671 adjuvant Substances 0.000 claims description 9
- 230000007815 allergy Effects 0.000 claims description 9
- 230000004927 fusion Effects 0.000 claims description 9
- 238000001990 intravenous administration Methods 0.000 claims description 9
- 201000006417 multiple sclerosis Diseases 0.000 claims description 9
- 238000007920 subcutaneous administration Methods 0.000 claims description 9
- 238000010171 animal model Methods 0.000 claims description 8
- 230000004968 inflammatory condition Effects 0.000 claims description 8
- 238000000926 separation method Methods 0.000 claims description 8
- 229960005486 vaccine Drugs 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 238000007918 intramuscular administration Methods 0.000 claims description 7
- 230000006872 improvement Effects 0.000 claims description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
- 210000000436 anus Anatomy 0.000 claims description 4
- 238000002405 diagnostic procedure Methods 0.000 claims description 4
- 241000588724 Escherichia coli Species 0.000 claims description 3
- 210000003928 nasal cavity Anatomy 0.000 claims description 3
- 231100000614 poison Toxicity 0.000 claims description 3
- 210000001215 vagina Anatomy 0.000 claims description 3
- 239000002574 poison Substances 0.000 claims description 2
- 230000029305 taxis Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract description 27
- 229960003444 immunosuppressant agent Drugs 0.000 abstract description 26
- 230000001861 immunosuppressant effect Effects 0.000 abstract description 26
- 241000713887 Human endogenous retrovirus Species 0.000 abstract description 19
- 230000033228 biological regulation Effects 0.000 abstract description 7
- 230000001900 immune effect Effects 0.000 abstract description 7
- 210000004027 cell Anatomy 0.000 description 194
- 235000018102 proteins Nutrition 0.000 description 185
- 235000001014 amino acid Nutrition 0.000 description 164
- 229940100601 interleukin-6 Drugs 0.000 description 65
- 239000000463 material Substances 0.000 description 61
- 238000002513 implantation Methods 0.000 description 54
- 241000699666 Mus <mouse, genus> Species 0.000 description 49
- 241001430294 unidentified retrovirus Species 0.000 description 47
- 208000011580 syndromic disease Diseases 0.000 description 40
- 230000001363 autoimmune Effects 0.000 description 34
- 230000001506 immunosuppresive effect Effects 0.000 description 29
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 28
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 28
- 238000011160 research Methods 0.000 description 27
- 239000012620 biological material Substances 0.000 description 26
- 230000006870 function Effects 0.000 description 25
- 108090000695 Cytokines Proteins 0.000 description 24
- 150000001875 compounds Chemical class 0.000 description 24
- 102000004127 Cytokines Human genes 0.000 description 23
- 241000578472 Human endogenous retrovirus H Species 0.000 description 23
- 230000028993 immune response Effects 0.000 description 21
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 21
- 206010034277 Pemphigoid Diseases 0.000 description 19
- 230000015572 biosynthetic process Effects 0.000 description 19
- 230000000903 blocking effect Effects 0.000 description 18
- 239000002158 endotoxin Substances 0.000 description 18
- 229920006008 lipopolysaccharide Polymers 0.000 description 18
- 239000000126 substance Substances 0.000 description 18
- 230000006378 damage Effects 0.000 description 17
- 239000000523 sample Substances 0.000 description 17
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 16
- 102100034349 Integrase Human genes 0.000 description 16
- 241001465754 Metazoa Species 0.000 description 16
- 210000001744 T-lymphocyte Anatomy 0.000 description 16
- 206010047115 Vasculitis Diseases 0.000 description 16
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 15
- 206010018910 Haemolysis Diseases 0.000 description 15
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 15
- 102000003814 Interleukin-10 Human genes 0.000 description 15
- 108090000174 Interleukin-10 Proteins 0.000 description 15
- 230000008859 change Effects 0.000 description 15
- 108020004999 messenger RNA Proteins 0.000 description 15
- 229920000642 polymer Polymers 0.000 description 15
- 238000012545 processing Methods 0.000 description 15
- 238000003786 synthesis reaction Methods 0.000 description 15
- 238000012360 testing method Methods 0.000 description 15
- 208000006454 hepatitis Diseases 0.000 description 14
- 238000010172 mouse model Methods 0.000 description 14
- 239000000047 product Substances 0.000 description 14
- 101710091045 Envelope protein Proteins 0.000 description 13
- 101710188315 Protein X Proteins 0.000 description 13
- 230000002917 arthritic effect Effects 0.000 description 13
- 230000008588 hemolysis Effects 0.000 description 13
- 231100000283 hepatitis Toxicity 0.000 description 13
- 230000001965 increasing effect Effects 0.000 description 13
- 239000002674 ointment Substances 0.000 description 13
- 230000000770 proinflammatory effect Effects 0.000 description 13
- 208000024891 symptom Diseases 0.000 description 13
- 206010028980 Neoplasm Diseases 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- 201000011510 cancer Diseases 0.000 description 12
- 238000011161 development Methods 0.000 description 12
- 230000018109 developmental process Effects 0.000 description 12
- 208000015181 infectious disease Diseases 0.000 description 12
- 230000005764 inhibitory process Effects 0.000 description 12
- 239000002245 particle Substances 0.000 description 12
- 208000032514 Leukocytoclastic vasculitis Diseases 0.000 description 11
- 125000000539 amino acid group Chemical group 0.000 description 11
- 239000000539 dimer Substances 0.000 description 11
- 238000006467 substitution reaction Methods 0.000 description 11
- 208000009299 Benign Mucous Membrane Pemphigoid Diseases 0.000 description 10
- 208000007465 Giant cell arteritis Diseases 0.000 description 10
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 10
- 208000012309 Linear IgA disease Diseases 0.000 description 10
- 208000012192 Mucous membrane pemphigoid Diseases 0.000 description 10
- 208000006045 Spondylarthropathies Diseases 0.000 description 10
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 10
- 230000005784 autoimmunity Effects 0.000 description 10
- 201000010002 cicatricial pemphigoid Diseases 0.000 description 10
- 239000001963 growth medium Substances 0.000 description 10
- 229960000485 methotrexate Drugs 0.000 description 10
- 239000002105 nanoparticle Substances 0.000 description 10
- 239000002773 nucleotide Substances 0.000 description 10
- 125000003729 nucleotide group Chemical group 0.000 description 10
- 230000000750 progressive effect Effects 0.000 description 10
- 201000005671 spondyloarthropathy Diseases 0.000 description 10
- 210000003371 toe Anatomy 0.000 description 10
- 206010015150 Erythema Diseases 0.000 description 9
- 102000000589 Interleukin-1 Human genes 0.000 description 9
- 108010002352 Interleukin-1 Proteins 0.000 description 9
- 108090001007 Interleukin-8 Proteins 0.000 description 9
- 102000004890 Interleukin-8 Human genes 0.000 description 9
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 9
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 9
- 210000003719 b-lymphocyte Anatomy 0.000 description 9
- 206010014599 encephalitis Diseases 0.000 description 9
- 231100000321 erythema Toxicity 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 206010025135 lupus erythematosus Diseases 0.000 description 9
- 239000000825 pharmaceutical preparation Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 230000002103 transcriptional effect Effects 0.000 description 9
- 238000001890 transfection Methods 0.000 description 9
- 208000008190 Agammaglobulinemia Diseases 0.000 description 8
- PHEDXBVPIONUQT-UHFFFAOYSA-N Cocarcinogen A1 Natural products CCCCCCCCCCCCCC(=O)OC1C(C)C2(O)C3C=C(C)C(=O)C3(O)CC(CO)=CC2C2C1(OC(C)=O)C2(C)C PHEDXBVPIONUQT-UHFFFAOYSA-N 0.000 description 8
- 208000015943 Coeliac disease Diseases 0.000 description 8
- 208000011231 Crohn disease Diseases 0.000 description 8
- 238000002965 ELISA Methods 0.000 description 8
- 206010018364 Glomerulonephritis Diseases 0.000 description 8
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 description 8
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 description 8
- 208000005615 Interstitial Cystitis Diseases 0.000 description 8
- 244000062730 Melissa officinalis Species 0.000 description 8
- 235000010654 Melissa officinalis Nutrition 0.000 description 8
- 108091028043 Nucleic acid sequence Proteins 0.000 description 8
- 206010042276 Subacute endocarditis Diseases 0.000 description 8
- 210000000845 cartilage Anatomy 0.000 description 8
- 238000004132 cross linking Methods 0.000 description 8
- 230000034994 death Effects 0.000 description 8
- 201000002491 encephalomyelitis Diseases 0.000 description 8
- 210000003743 erythrocyte Anatomy 0.000 description 8
- 230000002519 immonomodulatory effect Effects 0.000 description 8
- 238000011534 incubation Methods 0.000 description 8
- 238000003780 insertion Methods 0.000 description 8
- 230000037431 insertion Effects 0.000 description 8
- 239000000865 liniment Substances 0.000 description 8
- 239000006210 lotion Substances 0.000 description 8
- 230000004048 modification Effects 0.000 description 8
- 238000012986 modification Methods 0.000 description 8
- 239000003921 oil Substances 0.000 description 8
- 230000008506 pathogenesis Effects 0.000 description 8
- 239000013612 plasmid Substances 0.000 description 8
- 201000000306 sarcoidosis Diseases 0.000 description 8
- 239000002453 shampoo Substances 0.000 description 8
- 210000002784 stomach Anatomy 0.000 description 8
- 208000008467 subacute bacterial endocarditis Diseases 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 8
- 230000003612 virological effect Effects 0.000 description 8
- 206010009900 Colitis ulcerative Diseases 0.000 description 7
- 102000008186 Collagen Human genes 0.000 description 7
- 108010035532 Collagen Proteins 0.000 description 7
- 108020004414 DNA Proteins 0.000 description 7
- 201000004624 Dermatitis Diseases 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 108010074328 Interferon-gamma Proteins 0.000 description 7
- 206010030113 Oedema Diseases 0.000 description 7
- 101150026634 SAA3 gene Proteins 0.000 description 7
- 201000006704 Ulcerative Colitis Diseases 0.000 description 7
- 239000002253 acid Substances 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
- 230000003110 anti-inflammatory effect Effects 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 229920001436 collagen Polymers 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 7
- 239000006260 foam Substances 0.000 description 7
- 239000000499 gel Substances 0.000 description 7
- 230000006698 induction Effects 0.000 description 7
- 210000000265 leukocyte Anatomy 0.000 description 7
- 230000000670 limiting effect Effects 0.000 description 7
- 230000000926 neurological effect Effects 0.000 description 7
- 230000004044 response Effects 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- 230000000638 stimulation Effects 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- 108010078791 Carrier Proteins Proteins 0.000 description 6
- 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 description 6
- 208000009386 Experimental Arthritis Diseases 0.000 description 6
- 208000007882 Gastritis Diseases 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- 208000002193 Pain Diseases 0.000 description 6
- 201000004681 Psoriasis Diseases 0.000 description 6
- 201000001263 Psoriatic Arthritis Diseases 0.000 description 6
- 208000036824 Psoriatic arthropathy Diseases 0.000 description 6
- 206010037549 Purpura Diseases 0.000 description 6
- 241001672981 Purpura Species 0.000 description 6
- 206010046851 Uveitis Diseases 0.000 description 6
- 150000001408 amides Chemical class 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 239000007853 buffer solution Substances 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 description 6
- 230000009615 deamination Effects 0.000 description 6
- 238000006481 deamination reaction Methods 0.000 description 6
- 230000007812 deficiency Effects 0.000 description 6
- 239000000833 heterodimer Substances 0.000 description 6
- 201000006362 hypersensitivity vasculitis Diseases 0.000 description 6
- 210000000987 immune system Anatomy 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 210000000936 intestine Anatomy 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 210000001616 monocyte Anatomy 0.000 description 6
- 230000001575 pathological effect Effects 0.000 description 6
- 102000005962 receptors Human genes 0.000 description 6
- 108020003175 receptors Proteins 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 201000003068 rheumatic fever Diseases 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 230000008771 sex reversal Effects 0.000 description 6
- 206010043778 thyroiditis Diseases 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 206010056508 Acquired epidermolysis bullosa Diseases 0.000 description 5
- 206010000748 Acute febrile neutrophilic dermatosis Diseases 0.000 description 5
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 description 5
- 206010001935 American trypanosomiasis Diseases 0.000 description 5
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 description 5
- 206010003645 Atopy Diseases 0.000 description 5
- 206010069002 Autoimmune pancreatitis Diseases 0.000 description 5
- 208000031212 Autoimmune polyendocrinopathy Diseases 0.000 description 5
- 208000022106 Autoimmune polyendocrinopathy type 2 Diseases 0.000 description 5
- 208000009137 Behcet syndrome Diseases 0.000 description 5
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 5
- 208000033222 Biliary cirrhosis primary Diseases 0.000 description 5
- 208000009766 Blau syndrome Diseases 0.000 description 5
- 208000014644 Brain disease Diseases 0.000 description 5
- 102000014914 Carrier Proteins Human genes 0.000 description 5
- 208000005024 Castleman disease Diseases 0.000 description 5
- 208000024699 Chagas disease Diseases 0.000 description 5
- 206010008748 Chorea Diseases 0.000 description 5
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 description 5
- 208000010007 Cogan syndrome Diseases 0.000 description 5
- 208000027205 Congenital disease Diseases 0.000 description 5
- 208000029767 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Diseases 0.000 description 5
- 208000016192 Demyelinating disease Diseases 0.000 description 5
- 206010012438 Dermatitis atopic Diseases 0.000 description 5
- 208000032274 Encephalopathy Diseases 0.000 description 5
- 201000009273 Endometriosis Diseases 0.000 description 5
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 description 5
- 208000035895 Guillain-Barré syndrome Diseases 0.000 description 5
- 208000029470 Hughes-Stovin syndrome Diseases 0.000 description 5
- 208000010159 IgA glomerulonephritis Diseases 0.000 description 5
- 206010021263 IgA nephropathy Diseases 0.000 description 5
- 102100037850 Interferon gamma Human genes 0.000 description 5
- 208000003456 Juvenile Arthritis Diseases 0.000 description 5
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 5
- 201000010743 Lambert-Eaton myasthenic syndrome Diseases 0.000 description 5
- 206010024434 Lichen sclerosus Diseases 0.000 description 5
- 208000009777 Majeed syndrome Diseases 0.000 description 5
- 206010049567 Miller Fisher syndrome Diseases 0.000 description 5
- 206010027982 Morphoea Diseases 0.000 description 5
- 206010028424 Myasthenic syndrome Diseases 0.000 description 5
- 201000002481 Myositis Diseases 0.000 description 5
- 108700026244 Open Reading Frames Proteins 0.000 description 5
- 208000025174 PANDAS Diseases 0.000 description 5
- 206010053869 POEMS syndrome Diseases 0.000 description 5
- 208000021155 Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection Diseases 0.000 description 5
- 208000004788 Pars Planitis Diseases 0.000 description 5
- 201000011152 Pemphigus Diseases 0.000 description 5
- 208000031845 Pernicious anaemia Diseases 0.000 description 5
- 206010065159 Polychondritis Diseases 0.000 description 5
- 208000012654 Primary biliary cholangitis Diseases 0.000 description 5
- 208000005793 Restless legs syndrome Diseases 0.000 description 5
- 208000032384 Severe immune-mediated enteropathy Diseases 0.000 description 5
- 241000194017 Streptococcus Species 0.000 description 5
- 208000010265 Sweet syndrome Diseases 0.000 description 5
- 208000027522 Sydenham chorea Diseases 0.000 description 5
- 206010042742 Sympathetic ophthalmia Diseases 0.000 description 5
- 206010051526 Tolosa-Hunt syndrome Diseases 0.000 description 5
- 241000223109 Trypanosoma cruzi Species 0.000 description 5
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 5
- 230000002776 aggregation Effects 0.000 description 5
- 238000004220 aggregation Methods 0.000 description 5
- 208000004631 alopecia areata Diseases 0.000 description 5
- 125000003275 alpha amino acid group Chemical group 0.000 description 5
- 210000001367 artery Anatomy 0.000 description 5
- 201000008937 atopic dermatitis Diseases 0.000 description 5
- 208000010668 atopic eczema Diseases 0.000 description 5
- 208000001974 autoimmune enteropathy Diseases 0.000 description 5
- 201000009780 autoimmune polyendocrine syndrome type 2 Diseases 0.000 description 5
- 206010071572 autoimmune progesterone dermatitis Diseases 0.000 description 5
- 208000000594 bullous pemphigoid Diseases 0.000 description 5
- 238000007385 chemical modification Methods 0.000 description 5
- 208000037976 chronic inflammation Diseases 0.000 description 5
- 230000006020 chronic inflammation Effects 0.000 description 5
- 230000015271 coagulation Effects 0.000 description 5
- 238000005345 coagulation Methods 0.000 description 5
- 239000002299 complementary DNA Substances 0.000 description 5
- 239000000470 constituent Substances 0.000 description 5
- 230000000875 corresponding effect Effects 0.000 description 5
- 201000001981 dermatomyositis Diseases 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 201000004997 drug-induced lupus erythematosus Diseases 0.000 description 5
- 201000011114 epidermolysis bullosa acquisita Diseases 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- 201000001505 hemoglobinuria Diseases 0.000 description 5
- 239000000710 homodimer Substances 0.000 description 5
- 230000036039 immunity Effects 0.000 description 5
- 238000009169 immunotherapy Methods 0.000 description 5
- 201000008319 inclusion body myositis Diseases 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 description 5
- 206010028417 myasthenia gravis Diseases 0.000 description 5
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 description 5
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 description 5
- 208000028780 ocular motility disease Diseases 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 201000005580 palindromic rheumatism Diseases 0.000 description 5
- 201000001976 pemphigus vulgaris Diseases 0.000 description 5
- 208000027232 peripheral nervous system disease Diseases 0.000 description 5
- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 5
- 208000005987 polymyositis Diseases 0.000 description 5
- 239000013641 positive control Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000017854 proteolysis Effects 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 201000000980 schizophrenia Diseases 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- 208000020408 systemic-onset juvenile idiopathic arthritis Diseases 0.000 description 5
- 206010043207 temporal arteritis Diseases 0.000 description 5
- 206010043554 thrombocytopenia Diseases 0.000 description 5
- 231100000331 toxic Toxicity 0.000 description 5
- 230000002588 toxic effect Effects 0.000 description 5
- 208000009174 transverse myelitis Diseases 0.000 description 5
- 210000000707 wrist Anatomy 0.000 description 5
- 102100036126 60S ribosomal protein L37a Human genes 0.000 description 4
- 208000002874 Acne Vulgaris Diseases 0.000 description 4
- 208000026872 Addison Disease Diseases 0.000 description 4
- 208000002485 Adiposis dolorosa Diseases 0.000 description 4
- 108700028369 Alleles Proteins 0.000 description 4
- 201000001320 Atherosclerosis Diseases 0.000 description 4
- 201000006390 Brachial Plexus Neuritis Diseases 0.000 description 4
- 201000002829 CREST Syndrome Diseases 0.000 description 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 4
- 201000000724 Chronic recurrent multifocal osteomyelitis Diseases 0.000 description 4
- 208000019707 Cryoglobulinemic vasculitis Diseases 0.000 description 4
- 208000014311 Cushing syndrome Diseases 0.000 description 4
- 208000027219 Deficiency disease Diseases 0.000 description 4
- 206010012442 Dermatitis contact Diseases 0.000 description 4
- 206010012468 Dermatitis herpetiformis Diseases 0.000 description 4
- 206010014954 Eosinophilic fasciitis Diseases 0.000 description 4
- 206010015226 Erythema nodosum Diseases 0.000 description 4
- 206010016654 Fibrosis Diseases 0.000 description 4
- 206010017807 Gastric mucosal hypertrophy Diseases 0.000 description 4
- 208000024869 Goodpasture syndrome Diseases 0.000 description 4
- 208000003807 Graves Disease Diseases 0.000 description 4
- 208000015023 Graves' disease Diseases 0.000 description 4
- 208000030836 Hashimoto thyroiditis Diseases 0.000 description 4
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 4
- 206010019939 Herpes gestationis Diseases 0.000 description 4
- 101001092424 Homo sapiens 60S ribosomal protein L37a Proteins 0.000 description 4
- 208000000239 Hypertrophic Gastritis Diseases 0.000 description 4
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 4
- 208000000209 Isaacs syndrome Diseases 0.000 description 4
- 208000011200 Kawasaki disease Diseases 0.000 description 4
- 208000021642 Muscular disease Diseases 0.000 description 4
- 201000009623 Myopathy Diseases 0.000 description 4
- 206010029164 Nephrotic syndrome Diseases 0.000 description 4
- 206010029229 Neuralgic amyotrophy Diseases 0.000 description 4
- 206010072359 Neuromyotonia Diseases 0.000 description 4
- 206010048705 Paraneoplastic cerebellar degeneration Diseases 0.000 description 4
- 208000008223 Pemphigoid Gestationis Diseases 0.000 description 4
- 208000000766 Pityriasis Lichenoides Diseases 0.000 description 4
- 206010048895 Pityriasis lichenoides et varioliformis acuta Diseases 0.000 description 4
- 208000008601 Polycythemia Diseases 0.000 description 4
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 description 4
- 208000037534 Progressive hemifacial atrophy Diseases 0.000 description 4
- 208000012322 Raynaud phenomenon Diseases 0.000 description 4
- PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 description 4
- 206010039085 Rhinitis allergic Diseases 0.000 description 4
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 description 4
- 201000009594 Systemic Scleroderma Diseases 0.000 description 4
- 206010042953 Systemic sclerosis Diseases 0.000 description 4
- 208000001106 Takayasu Arteritis Diseases 0.000 description 4
- 208000025851 Undifferentiated connective tissue disease Diseases 0.000 description 4
- 208000017379 Undifferentiated connective tissue syndrome Diseases 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 206010000496 acne Diseases 0.000 description 4
- 125000002252 acyl group Chemical group 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 201000010105 allergic rhinitis Diseases 0.000 description 4
- 125000003277 amino group Chemical group 0.000 description 4
- 208000007502 anemia Diseases 0.000 description 4
- 210000003423 ankle Anatomy 0.000 description 4
- 230000002456 anti-arthritic effect Effects 0.000 description 4
- 201000004984 autoimmune cardiomyopathy Diseases 0.000 description 4
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 description 4
- 208000027625 autoimmune inner ear disease Diseases 0.000 description 4
- 201000004339 autoimmune neuropathy Diseases 0.000 description 4
- 208000029407 autoimmune urticaria Diseases 0.000 description 4
- 201000004982 autoimmune uveitis Diseases 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 235000013339 cereals Nutrition 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 description 4
- 208000024376 chronic urticaria Diseases 0.000 description 4
- 210000000078 claw Anatomy 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 4
- 208000010247 contact dermatitis Diseases 0.000 description 4
- 201000003278 cryoglobulinemia Diseases 0.000 description 4
- 208000004921 cutaneous lupus erythematosus Diseases 0.000 description 4
- 238000001212 derivatisation Methods 0.000 description 4
- 230000009266 disease activity Effects 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 235000013601 eggs Nutrition 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 206010014910 enthesopathy Diseases 0.000 description 4
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 208000002980 facial hemiatrophy Diseases 0.000 description 4
- 230000004761 fibrosis Effects 0.000 description 4
- 230000034659 glycolysis Effects 0.000 description 4
- 230000013595 glycosylation Effects 0.000 description 4
- 238000006206 glycosylation reaction Methods 0.000 description 4
- 201000007162 hidradenitis suppurativa Diseases 0.000 description 4
- 230000009610 hypersensitivity Effects 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 208000036971 interstitial lung disease 2 Diseases 0.000 description 4
- 150000002576 ketones Chemical class 0.000 description 4
- 201000011486 lichen planus Diseases 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 210000002540 macrophage Anatomy 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 description 4
- 208000009928 nephrosis Diseases 0.000 description 4
- 231100001027 nephrosis Toxicity 0.000 description 4
- 210000005036 nerve Anatomy 0.000 description 4
- 201000001119 neuropathy Diseases 0.000 description 4
- 230000007823 neuropathy Effects 0.000 description 4
- 230000000422 nocturnal effect Effects 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 230000010412 perfusion Effects 0.000 description 4
- 230000008823 permeabilization Effects 0.000 description 4
- 201000009395 primary hyperaldosteronism Diseases 0.000 description 4
- 238000011321 prophylaxis Methods 0.000 description 4
- 208000005069 pulmonary fibrosis Diseases 0.000 description 4
- 238000003753 real-time PCR Methods 0.000 description 4
- 208000009169 relapsing polychondritis Diseases 0.000 description 4
- 230000001177 retroviral effect Effects 0.000 description 4
- 238000010839 reverse transcription Methods 0.000 description 4
- 230000002441 reversible effect Effects 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 206010040400 serum sickness Diseases 0.000 description 4
- 230000002269 spontaneous effect Effects 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- 230000008685 targeting Effects 0.000 description 4
- TWNIBLMWSKIRAT-RWOPYEJCSA-N (1r,2s,3s,4s,5r)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol Chemical compound O1[C@@]2([H])OC[C@]1([H])[C@@H](O)[C@H](O)[C@@H]2O TWNIBLMWSKIRAT-RWOPYEJCSA-N 0.000 description 3
- XGWFJBFNAQHLEF-UHFFFAOYSA-N 9-anthroic acid Chemical compound C1=CC=C2C(C(=O)O)=C(C=CC=C3)C3=CC2=C1 XGWFJBFNAQHLEF-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 3
- 206010071155 Autoimmune arthritis Diseases 0.000 description 3
- 208000000659 Autoimmune lymphoproliferative syndrome Diseases 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 102100035904 Caspase-1 Human genes 0.000 description 3
- 108090000426 Caspase-1 Proteins 0.000 description 3
- 206010008609 Cholangitis sclerosing Diseases 0.000 description 3
- 102000002734 Collagen Type VI Human genes 0.000 description 3
- 108010043741 Collagen Type VI Proteins 0.000 description 3
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- 241000283073 Equus caballus Species 0.000 description 3
- 108700039887 Essential Genes Proteins 0.000 description 3
- 102000003777 Interleukin-1 beta Human genes 0.000 description 3
- 108090000193 Interleukin-1 beta Proteins 0.000 description 3
- 102000015696 Interleukins Human genes 0.000 description 3
- 108010063738 Interleukins Proteins 0.000 description 3
- 102000012750 Membrane Glycoproteins Human genes 0.000 description 3
- 108010090054 Membrane Glycoproteins Proteins 0.000 description 3
- 241001494479 Pecora Species 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 208000034189 Sclerosis Diseases 0.000 description 3
- 241000282898 Sus scrofa Species 0.000 description 3
- 206010052779 Transplant rejections Diseases 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 208000038016 acute inflammation Diseases 0.000 description 3
- 230000006022 acute inflammation Effects 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 239000002260 anti-inflammatory agent Substances 0.000 description 3
- 229940124599 anti-inflammatory drug Drugs 0.000 description 3
- 238000004820 blood count Methods 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 239000012267 brine Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000012512 characterization method Methods 0.000 description 3
- 208000013507 chronic prostatitis Diseases 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 210000001072 colon Anatomy 0.000 description 3
- 208000018631 connective tissue disease Diseases 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000005336 cracking Methods 0.000 description 3
- 235000018417 cysteine Nutrition 0.000 description 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 230000003210 demyelinating effect Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 229940126534 drug product Drugs 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 230000001605 fetal effect Effects 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 102000009634 interleukin-1 receptor antagonist activity proteins Human genes 0.000 description 3
- 108040001669 interleukin-1 receptor antagonist activity proteins Proteins 0.000 description 3
- 229940047122 interleukins Drugs 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 206010025482 malaise Diseases 0.000 description 3
- 210000004962 mammalian cell Anatomy 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 208000008795 neuromyelitis optica Diseases 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 230000003950 pathogenic mechanism Effects 0.000 description 3
- 230000026731 phosphorylation Effects 0.000 description 3
- 238000006366 phosphorylation reaction Methods 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 201000007094 prostatitis Diseases 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- 230000009711 regulatory function Effects 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 208000010157 sclerosing cholangitis Diseases 0.000 description 3
- 208000013223 septicemia Diseases 0.000 description 3
- 230000035939 shock Effects 0.000 description 3
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 201000004595 synovitis Diseases 0.000 description 3
- 238000012795 verification Methods 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
- NHJVRSWLHSJWIN-UHFFFAOYSA-N 2,4,6-trinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O NHJVRSWLHSJWIN-UHFFFAOYSA-N 0.000 description 2
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 2
- 206010000871 Acute monocytic leukaemia Diseases 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 102400000107 C-terminal peptide Human genes 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 238000011763 DBA/1J (JAX™ mouse strain) Methods 0.000 description 2
- 208000021866 Dressler syndrome Diseases 0.000 description 2
- 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 description 2
- 101710121417 Envelope glycoprotein Proteins 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 206010020651 Hyperkinesia Diseases 0.000 description 2
- 208000000269 Hyperkinesis Diseases 0.000 description 2
- 208000014919 IgG4-related retroperitoneal fibrosis Diseases 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 102000008070 Interferon-gamma Human genes 0.000 description 2
- 102100020881 Interleukin-1 alpha Human genes 0.000 description 2
- 102000013462 Interleukin-12 Human genes 0.000 description 2
- 108010065805 Interleukin-12 Proteins 0.000 description 2
- 108010082786 Interleukin-1alpha Proteins 0.000 description 2
- 108090000978 Interleukin-4 Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241000712079 Measles morbillivirus Species 0.000 description 2
- 102000018697 Membrane Proteins Human genes 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 2
- 108091092878 Microsatellite Proteins 0.000 description 2
- 208000003250 Mixed connective tissue disease Diseases 0.000 description 2
- 208000035489 Monocytic Acute Leukemia Diseases 0.000 description 2
- 208000003926 Myelitis Diseases 0.000 description 2
- BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 description 2
- 206010053159 Organ failure Diseases 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 241001111421 Pannus Species 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 108010033276 Peptide Fragments Proteins 0.000 description 2
- 102000007079 Peptide Fragments Human genes 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 102000004257 Potassium Channel Human genes 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- 108010076504 Protein Sorting Signals Proteins 0.000 description 2
- 208000003670 Pure Red-Cell Aplasia Diseases 0.000 description 2
- 238000001190 Q-PCR Methods 0.000 description 2
- 239000012980 RPMI-1640 medium Substances 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 206010038979 Retroperitoneal fibrosis Diseases 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 201000010848 Schnitzler Syndrome Diseases 0.000 description 2
- 102000054727 Serum Amyloid A Human genes 0.000 description 2
- 101710190759 Serum amyloid A protein Proteins 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 201000001322 T cell deficiency Diseases 0.000 description 2
- 102000002689 Toll-like receptor Human genes 0.000 description 2
- 108020000411 Toll-like receptor Proteins 0.000 description 2
- 102100039390 Toll-like receptor 7 Human genes 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 2
- 241000711975 Vesicular stomatitis virus Species 0.000 description 2
- 102000007624 ZAP-70 Protein-Tyrosine Kinase Human genes 0.000 description 2
- 108010046882 ZAP-70 Protein-Tyrosine Kinase Proteins 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- 230000021736 acetylation Effects 0.000 description 2
- 238000006640 acetylation reaction Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 230000005875 antibody response Effects 0.000 description 2
- 108010030694 avidin-horseradish peroxidase complex Proteins 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 208000002352 blister Diseases 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 230000021523 carboxylation Effects 0.000 description 2
- 238000006473 carboxylation reaction Methods 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000011748 cell maturation Effects 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 230000036755 cellular response Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 125000003636 chemical group Chemical group 0.000 description 2
- 239000013626 chemical specie Substances 0.000 description 2
- 208000003167 cholangitis Diseases 0.000 description 2
- 206010009887 colitis Diseases 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
- 230000000911 decarboxylating effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000022811 deglycosylation Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 229950006137 dexfosfoserine Drugs 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 206010014665 endocarditis Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000037902 enteropathy Diseases 0.000 description 2
- 108700004025 env Genes Proteins 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 210000003754 fetus Anatomy 0.000 description 2
- 238000013467 fragmentation Methods 0.000 description 2
- 238000006062 fragmentation reaction Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 235000013922 glutamic acid Nutrition 0.000 description 2
- 239000004220 glutamic acid Substances 0.000 description 2
- 230000001279 glycosylating effect Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 210000003709 heart valve Anatomy 0.000 description 2
- 230000000004 hemodynamic effect Effects 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 2
- 229940099552 hyaluronan Drugs 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 208000013403 hyperactivity Diseases 0.000 description 2
- 230000008629 immune suppression Effects 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 229960003130 interferon gamma Drugs 0.000 description 2
- 208000028774 intestinal disease Diseases 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 210000001503 joint Anatomy 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 238000011813 knockout mouse model Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 229960004194 lidocaine Drugs 0.000 description 2
- 210000003041 ligament Anatomy 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 201000001268 lymphoproliferative syndrome Diseases 0.000 description 2
- 210000003712 lysosome Anatomy 0.000 description 2
- 230000001868 lysosomic effect Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 230000009871 nonspecific binding Effects 0.000 description 2
- 238000010606 normalization Methods 0.000 description 2
- 210000004940 nucleus Anatomy 0.000 description 2
- 210000001328 optic nerve Anatomy 0.000 description 2
- 230000004768 organ dysfunction Effects 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 210000002997 osteoclast Anatomy 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 2
- USRGIUJOYOXOQJ-GBXIJSLDSA-N phosphothreonine Chemical compound OP(=O)(O)O[C@H](C)[C@H](N)C(O)=O USRGIUJOYOXOQJ-GBXIJSLDSA-N 0.000 description 2
- DCWXELXMIBXGTH-UHFFFAOYSA-N phosphotyrosine Chemical compound OC(=O)C(N)CC1=CC=C(OP(O)(O)=O)C=C1 DCWXELXMIBXGTH-UHFFFAOYSA-N 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 108020001213 potassium channel Proteins 0.000 description 2
- 150000003141 primary amines Chemical class 0.000 description 2
- 201000000742 primary sclerosing cholangitis Diseases 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- HSSLDCABUXLXKM-UHFFFAOYSA-N resorufin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3N=C21 HSSLDCABUXLXKM-UHFFFAOYSA-N 0.000 description 2
- 230000002784 sclerotic effect Effects 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 210000001258 synovial membrane Anatomy 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 239000011534 wash buffer Substances 0.000 description 2
- 210000004885 white matter Anatomy 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 108020004463 18S ribosomal RNA Proteins 0.000 description 1
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- MUKYLHIZBOASDM-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid 2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound NC(=N)N(C)CC(O)=O.OCC(O)C(O)C(O)C(O)C(O)=O MUKYLHIZBOASDM-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 1
- TVZRAEYQIKYCPH-UHFFFAOYSA-N 3-(trimethylsilyl)propane-1-sulfonic acid Chemical compound C[Si](C)(C)CCCS(O)(=O)=O TVZRAEYQIKYCPH-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 101150037123 APOE gene Proteins 0.000 description 1
- 206010048998 Acute phase reaction Diseases 0.000 description 1
- 102000011767 Acute-Phase Proteins Human genes 0.000 description 1
- 108010062271 Acute-Phase Proteins Proteins 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 239000012099 Alexa Fluor family Substances 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241001614291 Anoplistes Species 0.000 description 1
- 101710099705 Anti-lipopolysaccharide factor Proteins 0.000 description 1
- 208000032467 Aplastic anaemia Diseases 0.000 description 1
- 102100029470 Apolipoprotein E Human genes 0.000 description 1
- 102000013918 Apolipoproteins E Human genes 0.000 description 1
- 108010025628 Apolipoproteins E Proteins 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010053555 Arthritis bacterial Diseases 0.000 description 1
- 206010071576 Autoimmune aplastic anaemia Diseases 0.000 description 1
- 201000008162 B cell deficiency Diseases 0.000 description 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 1
- 238000011729 BALB/c nude mouse Methods 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 description 1
- 102000003922 Calcium Channels Human genes 0.000 description 1
- 108090000312 Calcium Channels Proteins 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 102000003846 Carbonic anhydrases Human genes 0.000 description 1
- 108090000209 Carbonic anhydrases Proteins 0.000 description 1
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 description 1
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 241000283153 Cetacea Species 0.000 description 1
- 241000905957 Channa melasoma Species 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 102000034573 Channels Human genes 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 241000219104 Cucurbitaceae Species 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 206010051055 Deep vein thrombosis Diseases 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241001115402 Ebolavirus Species 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 206010058838 Enterocolitis infectious Diseases 0.000 description 1
- 206010049466 Erythroblastosis Diseases 0.000 description 1
- 208000001640 Fibromyalgia Diseases 0.000 description 1
- 208000004262 Food Hypersensitivity Diseases 0.000 description 1
- 206010061958 Food Intolerance Diseases 0.000 description 1
- 206010016946 Food allergy Diseases 0.000 description 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
- 102100035233 Furin Human genes 0.000 description 1
- 108090001126 Furin Proteins 0.000 description 1
- 108091006027 G proteins Proteins 0.000 description 1
- 102000030782 GTP binding Human genes 0.000 description 1
- 108091000058 GTP-Binding Proteins 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010064571 Gene mutation Diseases 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- 241000235503 Glomus Species 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 108010058597 HLA-DR Antigens Proteins 0.000 description 1
- 102000006354 HLA-DR Antigens Human genes 0.000 description 1
- 108010093013 HLA-DR1 Antigen Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 229920000209 Hexadimethrine bromide Polymers 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 1
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 description 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
- 241000192019 Human endogenous retrovirus K Species 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 208000027601 Inner ear disease Diseases 0.000 description 1
- 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 description 1
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 1
- 108090000177 Interleukin-11 Proteins 0.000 description 1
- 102000013691 Interleukin-17 Human genes 0.000 description 1
- 108050003558 Interleukin-17 Proteins 0.000 description 1
- 102000010781 Interleukin-6 Receptors Human genes 0.000 description 1
- 108010038501 Interleukin-6 Receptors Proteins 0.000 description 1
- 208000029523 Interstitial Lung disease Diseases 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- 102000037862 Ion Transporter Human genes 0.000 description 1
- 108091006671 Ion Transporter Proteins 0.000 description 1
- 206010060820 Joint injury Diseases 0.000 description 1
- 206010023232 Joint swelling Diseases 0.000 description 1
- 150000008540 L-glutamines Chemical class 0.000 description 1
- 208000017119 Labyrinth disease Diseases 0.000 description 1
- 208000008771 Lymphadenopathy Diseases 0.000 description 1
- 206010027336 Menstruation delayed Diseases 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 1
- 101150076359 Mhc gene Proteins 0.000 description 1
- 208000010718 Multiple Organ Failure Diseases 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 241000699729 Muridae Species 0.000 description 1
- 208000029578 Muscle disease Diseases 0.000 description 1
- 206010050031 Muscle strain Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 108091092724 Noncoding DNA Proteins 0.000 description 1
- 208000011623 Obstructive Lung disease Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 206010031252 Osteomyelitis Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 241000282577 Pan troglodytes Species 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 1
- 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 description 1
- 206010036105 Polyneuropathy Diseases 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 102400001018 Proadrenomedullin N-20 terminal peptide Human genes 0.000 description 1
- 101800000795 Proadrenomedullin N-20 terminal peptide Proteins 0.000 description 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 1
- 206010061926 Purulence Diseases 0.000 description 1
- 238000002123 RNA extraction Methods 0.000 description 1
- 239000013614 RNA sample Substances 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010038997 Retroviral infections Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 208000009921 Rheumatoid Nodule Diseases 0.000 description 1
- 230000018199 S phase Effects 0.000 description 1
- 238000011579 SCID mouse model Methods 0.000 description 1
- 108010017324 STAT3 Transcription Factor Proteins 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 108700028909 Serum Amyloid A Proteins 0.000 description 1
- 238000003457 Shi epoxidation reaction Methods 0.000 description 1
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 102000018674 Sodium Channels Human genes 0.000 description 1
- 108010052164 Sodium Channels Proteins 0.000 description 1
- 206010042220 Stress ulcer Diseases 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 210000004241 Th2 cell Anatomy 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000026062 Tissue disease Diseases 0.000 description 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 241000819233 Tribulus <sea snail> Species 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
- 102000004243 Tubulin Human genes 0.000 description 1
- 108090000704 Tubulin Proteins 0.000 description 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004658 acute-phase response Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 210000005006 adaptive immune system Anatomy 0.000 description 1
- 208000013228 adenopathy Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000003172 anti-dna Effects 0.000 description 1
- 239000003435 antirheumatic agent Substances 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 206010003230 arteritis Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000025255 bacterial arthritis Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000037058 blood plasma level Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000002639 bone cement Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 208000030270 breast disease Diseases 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000034303 cell budding Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 210000001638 cerebellum Anatomy 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 210000003477 cochlea Anatomy 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 201000003056 complement component 2 deficiency Diseases 0.000 description 1
- 230000004154 complement system Effects 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000010219 correlation analysis Methods 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N cystine group Chemical group C([C@@H](C(=O)O)N)SSC[C@@H](C(=O)O)N LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000006114 decarboxylation reaction Methods 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000004053 dental implant Substances 0.000 description 1
- 108010016290 deoxyribonucleoprotamine Proteins 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 208000007784 diverticulitis Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 238000001378 electrochemiluminescence detection Methods 0.000 description 1
- 210000001163 endosome Anatomy 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 108010048367 enhanced green fluorescent protein Proteins 0.000 description 1
- 101150030339 env gene Proteins 0.000 description 1
- 230000002327 eosinophilic effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 210000003617 erythrocyte membrane Anatomy 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- WVRIJHGUJNXDRZ-UHFFFAOYSA-N ethane-1,1-diamine Chemical class CC(N)N WVRIJHGUJNXDRZ-UHFFFAOYSA-N 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000013265 extended release Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000012921 fluorescence analysis Methods 0.000 description 1
- 235000020932 food allergy Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 230000000799 fusogenic effect Effects 0.000 description 1
- 108010074605 gamma-Globulins Proteins 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 238000005734 heterodimerization reaction Methods 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 description 1
- 229960004171 hydroxychloroquine Drugs 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 208000036260 idiopathic disease Diseases 0.000 description 1
- 230000008102 immune modulation Effects 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 238000010185 immunofluorescence analysis Methods 0.000 description 1
- 238000010820 immunofluorescence microscopy Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 229940124589 immunosuppressive drug Drugs 0.000 description 1
- 238000002650 immunosuppressive therapy Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 208000027139 infectious colitis Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000003960 inflammatory cascade Effects 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000008946 inflammatory intestinal reaction Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000001613 integumentary system Anatomy 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000003407 interleukin 1 receptor blocking agent Substances 0.000 description 1
- 230000010189 intracellular transport Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 208000001875 irritant dermatitis Diseases 0.000 description 1
- 208000018937 joint inflammation Diseases 0.000 description 1
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 201000010260 leiomyoma Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 206010024378 leukocytosis Diseases 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 208000018191 liver inflammation Diseases 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000004199 lung function Effects 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000005399 mechanical ventilation Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000029052 metamorphosis Effects 0.000 description 1
- 235000006109 methionine Nutrition 0.000 description 1
- 125000001360 methionine group Chemical class N[C@@H](CCSC)C(=O)* 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000272 myelencephalon Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000002151 myoclonic effect Effects 0.000 description 1
- 201000003631 narcolepsy Diseases 0.000 description 1
- 230000000955 neuroendocrine Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 108091027963 non-coding RNA Proteins 0.000 description 1
- 102000042567 non-coding RNA Human genes 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- PIRWNASAJNPKHT-SHZATDIYSA-N pamp Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N)C(C)C)C1=CC=CC=C1 PIRWNASAJNPKHT-SHZATDIYSA-N 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 230000007824 polyneuropathy Effects 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 229960000856 protein c Drugs 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 238000012755 real-time RT-PCR analysis Methods 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 108700004030 rev Genes Proteins 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 210000004406 stave cell Anatomy 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000005065 subchondral bone plate Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000002437 synoviocyte Anatomy 0.000 description 1
- 230000008718 systemic inflammatory response Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000003684 theca cell Anatomy 0.000 description 1
- 229960003989 tocilizumab Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000003146 transient transfection Methods 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229940047183 tribulus Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000000251 trophoblastic cell Anatomy 0.000 description 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000012646 vaccine adjuvant Substances 0.000 description 1
- 229940124931 vaccine adjuvant Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10033—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201570620 | 2015-10-01 | ||
| DKPA201570620 | 2015-10-01 | ||
| DKPA201670634 | 2016-08-23 | ||
| DKPA201670634 | 2016-08-23 | ||
| PCT/DK2016/050316 WO2017054831A1 (en) | 2015-10-01 | 2016-09-30 | Use of human derived immunosuppressive proteins and peptides as medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108368155A true CN108368155A (zh) | 2018-08-03 |
Family
ID=57144698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680070131.4A Pending CN108368155A (zh) | 2015-10-01 | 2016-09-30 | 人源性免疫抑制蛋白和肽作为药物的应用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20190040106A1 (https=) |
| EP (1) | EP3356389A1 (https=) |
| JP (1) | JP7037486B2 (https=) |
| CN (1) | CN108368155A (https=) |
| CA (1) | CA2999792A1 (https=) |
| WO (1) | WO2017054831A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111630060A (zh) * | 2017-09-01 | 2020-09-04 | 盈珀治疗有限公司 | 用于在疾病的预防和/或治疗中使用的疫苗 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3033262A1 (en) | 2016-08-23 | 2018-03-01 | Aimvion A/S | Novel immunostimulating peptides |
| US11352421B2 (en) | 2018-12-11 | 2022-06-07 | Rush University Medical Center | Treatment for adverse immune reaction to metal implant debris |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004087748A1 (en) * | 2003-04-04 | 2004-10-14 | Centre National De La Recherche Scientifique | Protein with fusogenic activity, nucleic acid sequences encoding said protein and pharmaceutical compositions comprising the same |
| CN1961001A (zh) * | 2004-03-30 | 2007-05-09 | 古斯达威罗斯研究所 | 参与病毒蛋白的免疫抑制作用的调节的多肽序列 |
| WO2011119484A1 (en) * | 2010-03-23 | 2011-09-29 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020048763A1 (en) * | 2000-02-04 | 2002-04-25 | Penn Sharron Gaynor | Human genome-derived single exon nucleic acid probes useful for gene expression analysis |
| EP2254592B1 (en) * | 2008-02-28 | 2019-06-05 | Dako Denmark A/S | Mhc multimers in borrelia diagnostics and disease |
-
2016
- 2016-09-30 JP JP2018536331A patent/JP7037486B2/ja not_active Expired - Fee Related
- 2016-09-30 CA CA2999792A patent/CA2999792A1/en not_active Abandoned
- 2016-09-30 CN CN201680070131.4A patent/CN108368155A/zh active Pending
- 2016-09-30 WO PCT/DK2016/050316 patent/WO2017054831A1/en not_active Ceased
- 2016-09-30 EP EP16782182.6A patent/EP3356389A1/en not_active Withdrawn
- 2016-09-30 US US15/764,714 patent/US20190040106A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004087748A1 (en) * | 2003-04-04 | 2004-10-14 | Centre National De La Recherche Scientifique | Protein with fusogenic activity, nucleic acid sequences encoding said protein and pharmaceutical compositions comprising the same |
| CN1961001A (zh) * | 2004-03-30 | 2007-05-09 | 古斯达威罗斯研究所 | 参与病毒蛋白的免疫抑制作用的调节的多肽序列 |
| WO2011119484A1 (en) * | 2010-03-23 | 2011-09-29 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
Non-Patent Citations (1)
| Title |
|---|
| NATHALIE DE PARSEVAL等: "Characterization of the Three HERV-H Proviruses with an Open Envelope Reading Frame Encompassing the Immunosuppressive Domain and Evolutionary History in Primates", 《VIROLOGY》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111630060A (zh) * | 2017-09-01 | 2020-09-04 | 盈珀治疗有限公司 | 用于在疾病的预防和/或治疗中使用的疫苗 |
| CN111630060B (zh) * | 2017-09-01 | 2024-01-23 | 盈珀治疗有限公司 | 用于在疾病的预防和/或治疗中使用的疫苗 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017054831A1 (en) | 2017-04-06 |
| US20190040106A1 (en) | 2019-02-07 |
| JP2018533974A (ja) | 2018-11-22 |
| CA2999792A1 (en) | 2017-04-06 |
| JP7037486B2 (ja) | 2022-03-16 |
| EP3356389A1 (en) | 2018-08-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2941965T3 (es) | Nuevos receptores de linfocito T genomanipulados e inmunoterapias basadas en el uso de los mismos | |
| WO2020227515A1 (en) | Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation | |
| UA125501C2 (uk) | Моноклональне антитіло, або його антигензв'язувальний фрагмент, яке здатне специфічно зв'язуватися з альфа-синуклеїном людини, його застосування та спосіб лікування синуклеопатії | |
| CN109891245A (zh) | 自身免疫疾病的诊断、预防和/或治疗 | |
| BRPI0720724A2 (pt) | Composições e métodos para o tratamento de infecções e tumores | |
| CN107441480A (zh) | 多肽及其作为用于治疗多发性硬化、类风湿性关节炎以及其他自身免疫病症的药物的用途 | |
| CN102282169A (zh) | 表达破骨细胞相关受体的细胞活性和分化的调节 | |
| EP3061766B1 (en) | Compositions and methods for the treatment of disorders involving epithelial cell apoptosis | |
| CN102725311A (zh) | 治疗发炎的方法 | |
| WO2021233885A1 (en) | Mimotope peptides of the spike protein from the sars-cov-2 virus | |
| CN101454341B (zh) | 表面核仁素的多价合成配体在治疗癌症或发炎中的用途 | |
| WO2019129892A1 (en) | T cell receptors for tumor specific proteasome splice variants and uses thereof | |
| CN108368155A (zh) | 人源性免疫抑制蛋白和肽作为药物的应用 | |
| CZ303409B6 (cs) | Zkrácený a mutovaný lidský chemokin | |
| CA2452593C (en) | Triple polypeptide complexes | |
| ES2936075T3 (es) | Activador de células T reguladoras, y uso del mismo | |
| JPH10501888A (ja) | 自己免疫疾患、とくに多発性硬化症の診断および治療における使用のためのアルファbクリスタリン | |
| WO2004052922A2 (en) | Peptides, antibodies thereto, and their use in the treatment of central nervous system damage | |
| EP3906931A2 (en) | Use of immune suppressive domains as medicaments | |
| WO2023056527A1 (en) | Proteinaceous molecules and uses therefor | |
| JP2011524747A (ja) | 真菌起源の感染および炎症プロセスを治療するためのcd5医薬組成物 | |
| WO2004092373A1 (ja) | Htlv-i特異的ctl誘導活性ペプチド | |
| EP1896055B1 (en) | Immune disease medicament comprising a modulator of the binding between a heparin binding domain of thrombospondin-1 and a beta1 integrin | |
| CN109929026A (zh) | 人源靶向补体抑制物蛋白mCR2-DAF及应用 | |
| CN110128547A (zh) | 人源靶向补体抑制物蛋白mCR2-fH及应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180803 |