CN108354978A - Moutan bark and its processing procedure - Google Patents
Moutan bark and its processing procedure Download PDFInfo
- Publication number
- CN108354978A CN108354978A CN201810509118.5A CN201810509118A CN108354978A CN 108354978 A CN108354978 A CN 108354978A CN 201810509118 A CN201810509118 A CN 201810509118A CN 108354978 A CN108354978 A CN 108354978A
- Authority
- CN
- China
- Prior art keywords
- moutan bark
- dry
- processing procedure
- moutan
- bacillus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to pharmaceutical technology fields, in particular to a kind of moutan bark and its processing procedure.The processing procedure of moutan bark includes the following steps：5 are fumigated to dry moutan bark using solvent to ferment 6 12 hours under conditions of temperature is 35 37 DEG C and humidity is 75 85% and interruption oxygen supply after the dry moutan bark surface injection microbial bacterial agent again after ten minutes, then again in described one layer of coating agent of dry moutan bark outer wrapping.Wherein, every milliliter of microbial bacterial agent includes 5 × 109~8 × 109A bacillus composition；The bacillus composition is mainly 1.2 1.5 according to mass ratio by Bacillus cercus and bacillus subtilis：1 quantity ratio is mixed.It is intended to promote the dissolution rate and stripping quantity of moutan bark active constituent, and extends the quality guarantee period of moutan bark.
Description
Technical field
The present invention relates to pharmaceutical technology fields, in particular to a kind of moutan bark and its processing procedure.
Background technology
Moutan bark, Chinese medicine name.For ranunculaceae peony dry root skin.It is bitter, pungent, it is slightly cold, the thoughts of returning home, liver and kidney channel have clear
Hot cool blood activates blood circulation and disperses blood clots, reducing the asthenic fever and other effects.The small toxicity of moutan bark and paeonol.The concocting method of moutan bark is usually fast
Speed is cleaned, and shave after profit dries.But the moutan bark active constituent that this method processes goes out compared with indissoluble, when later stage pharmacy, needs
It takes a long time tanning or multi-step was spent to extract, reduce the drug effect of Radix Paeoniae Alba, and increase the difficulty of later stage pharmacy
Degree.
Invention content
The present invention provides a kind of processing procedures of moutan bark, it is intended to promoted moutan bark active constituent dissolution rate and
Stripping quantity, and extend the quality guarantee period of moutan bark.
The present invention provides a kind of moutan barks, and in later stage pharmacy procedure, active constituent is easy extraction or dissolution, increases
Add its drug effect, reduces later stage pharmaceutical processing difficulty.
The invention is realized in this way：
A kind of processing procedure of moutan bark, includes the following steps：
After being fumigated 5-10 minutes using solvent to dry moutan bark again after the dry moutan bark surface injection microbial bacterial agent
It ferments 6-12 hours under conditions of temperature is 35-37 DEG C and humidity is 75-85% and interruption oxygen supply, then again described dry male
One layer of coating agent of root bark of tree peony outer wrapping；
Wherein, every milliliter of microbial bacterial agent includes 5 × 109~8 × 109A bacillus composition；The gemma bar
Bacteria composition is mainly 1.2-1.5 according to mass ratio by Bacillus cercus and bacillus subtilis：1 quantity is made than mixing
At.
A kind of moutan bark, the processing procedure through above-mentioned moutan bark are made.
The beneficial effects of the invention are as follows：A kind of processing procedure of moutan bark provided by the invention due to by moutan bark suitable
Under the conditions of air-dry, carry out surface disinfection after air-drying, kill the mould on moutan bark surface, effectively prevent subsequent fermentations moutan bark
It is mouldy, tree peony epidermis is then further suppressed using the microbial bacterial agent sprinkling moutan bark surface containing appropriate concentration bacillus
Face fungus growth, and the various enzymes of secreted from bacillus can promote moutan bark to ferment, harmful substance contains in reduction moutan bark
Amount, is conducive to the dissolution of moutan bark active constituent, and then wrapping up one layer of coating agent can prevent the intracutaneous active constituent of tree peony from existing
It is dissolved out during storage, extends its shelf-life.
Specific implementation mode
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
A kind of moutan bark of offer of the embodiment of the present invention and its processing procedure are specifically described below.
A kind of processing procedure of moutan bark, includes the following steps：
S1, pretreatment；
Specifically, fresh moutan bark of the buying without no insect pest fresh high-quality of going mouldy, the moutan bark purchased back is cleaned
To remove the silt or impurity on fresh moutan bark surface.Fresh moutan bark after cleaning is placed in temperature is 25-30 DEG C, humidity is
It is air-dried in the environment of 10-18%.It refers to that human hand feels difficult to handle feeling to air-dry herein.Temperature is slightly above or is equal to when air-drying
Room temperature, unsuitable excessively high, temperature is excessively high, and certain components in moutan bark can be made to change, may reduce drug effect, temperature when air-drying
Degree is unsuitable too low, and humidity is not to be exceeded 18%, may take considerable time for air-drying in this way.
The moutan bark slicing treatment after air-drying then is obtained into dry moutan bark, ensures the concocting process such as follow-up stifling, fermentation
Can be effective to every a piece of moutan bark, then ensure that every moutan bark can be processed, and ensure to process effect.
S2, it fumigates；
First, 5-10 minutes stifling using solvent to dry moutan bark, specifically being heated to solvent so that solvent
Become steam, then steam interacts with dry moutan bark, and dry tree peony skin structure is relatively compact, and solvent can enter dry tree peony
Intradermal portion, while making the structure of dry moutan bark of a relatively loose, but the complete structure of dry moutan bark is not interfered with, convenient for follow-up
The intracutaneous active constituent of tree peony is easier to dissolve out when pharmacy.
Meanwhile the stifling time is unsuitable long, if stifling overlong time, the solvent vapo(u)r for acting on dry moutan bark increases
Add, can be squeezed out in dry moutan bark by new solvent subsequently into the intracutaneous solvent of dry tree peony, while the solvent squeezed out can take away portion
The active constituent of point moutan bark then reduces the content of moutan bark active constituent, and if the stifling time it is too short, act on dry
The quantity of solvent of moutan bark is insufficient, and tree peony skin structure cannot be made just loose, be then unfavorable for active constituent in follow-up moutan bark
Dissolution.Therefore, it can not only ensure there is sufficient solvent vapo(u)r to be acted on dry moutan bark using the fumigation time of above range, but also can
To ensure that solvent will not carry away the intracutaneous active constituent of dry tree peony secretly.
Further, solvent includes the mixture of any one or the two in alcohols material and carboxylic-acid substance.
Further, alcohols material is monohydric alcohol, preferably C1-C4 monohydric alcohols, more preferably C1-C2 monohydric alcohols；
The carboxylic-acid substance is monoacid or binary acid, and the preferably described monoacid is C1-C3 monoacid, more preferably vinegar
Acid；
It is preferred that the binary acid is C4-C10 binary acid, more preferably ethanedioic acid.
Solvent uses alcohols material or carboxylic-acid substance, is that can reduce processing item since above-mentioned substance is more volatile
Part, meanwhile, above-mentioned substance can reduce the Side effect of moutan bark, heighten the effect of a treatment simultaneously.And C1-C2 monohydric alcohols, acetic acid
The substances such as ethanedioic acid can be easier to act on dry moutan bark, then form hole in dry moutan bark so that fine and close tree peony
Skin becomes loose, is then conducive to the intracutaneous active constituent dissolution of tree peony.
After the completion of stifling, then moutan bark is subjected to rapid freeze-drying, removes solvent, solvent forms hole in moutan bark
Hole so that moutan bark is loose, then is heated to moutan bark, although solvent can also be removed, solvent is waved out of moutan bark
It is easy entrainment when hair and walks active constituent, therefore, stifling moutan bark is lyophilized at once so that the intracutaneous solvent of tree peony is fixed on
In moutan bark, then directly distilling, solvent is not easy entrainment and walks the intracutaneous active constituent of tree peony, and after solvent removal, in moutan bark
The hole of formation does not also disappear, then ensures that the intracutaneous active constituent of tree peony is easier to be precipitated when follow-up pharmacy.Freeze-drying is ability
One of the drying means that domain is often used, is no longer described in detail herein.
S3, fermentation；
Sterilization processing is carried out to the dry moutan bark after freeze-drying, the mould on its surface is mainly killed, prevents subsequent fermentation mistake
It generates and goes mouldy in journey.Preferably, it being irradiated dry moutan bark 0.5-1 hours using using ultraviolet light, irradiation distance is 0.5-0.8 meters,
Uitraviolet intensity is 200-250 μ W/cm3.The microorganism on dry tree peony surface can be effectively killed under these conditions and can be promoted
The progress of fermentation.Uitraviolet intensity is unsuitable too strong or excessively weak, too strong that effective component in dry tree peony may be made to change, excessively weak
Then bactericidal effect is poor；Ultraviolet light irradiation distance should in 0.5-0.8m, this distance can make ultraviolet light more extensively more
It is irradiated to dry tree peony, and coordinates exposure intensity, enables to bactericidal effect best；Irradiation time be not easy it is long also unsuitable too short,
Too strong length may make effective component in dry tree peony change, excessively weak then bactericidal effect unobvious.
Microbial bacterial agent then is sprayed on the dry moutan bark surface, is dried after the completion of sprinkling, it should be noted that sprinkling
And dry process is carried out preferably in sterile or ventilated environment in order to avoid dry moutan bark surface contamination mould.
Further, every milliliter of microbial bacterial agent includes 5 × 109~8 × 109A bacillus composition.Using bud
Spore bacillus can effectively press down mycostatic growth, and lignin, the fibre on moutan bark surface can be consumed in bacillus growth course
Element etc. is tieed up, the dissolution of active material in moutan bark is then conducive to, while being gone unless medicinal effects, reduce the secondary of moutan bark and make
With.
Further, bacillus composition is mainly according to mass ratio by Bacillus cercus and bacillus subtilis
1.2-1.5：1 quantity ratio is mixed.Above-mentioned several bacillus bacterium mutual cooperation effects being capable of fast hydrolyzing tree peony epidermis
The substances such as cellulose, the pectin in face promote the volatilization of volatile oil, while can press down mycostatic growth.
Bacillus cercus can decompose carbohydrate without generating gas, can hydrolyze starch, accelerate moutan bark
Fermentation.Bacillus subtilis can inhibit the growth of pathogenic bacteria and can synthesize various enzymes and vitamin, and have resistance to height
The features such as warm, can promote the use scope of microbial bacterial agent, function and effect of the enhancing bacillus composition to moutan bark.Together
When, bacillus subtilis can also reduce enteron aisle oxygen content in human body, promote to grow beneficial to anaerobic bacteria, reduce moutan bark to digestion
The stimulation of system.Further, fermentation is fermented 6-12 hours under conditions of temperature is 35-37 DEG C and humidity is 75-85%.
Under these conditions, Bacillus cercus and bacillus subtilis can obtain good growth, then can fast decoupled it is male
The substances such as the lignin on root bark of tree peony surface.
Further, it is also supplied oxygen in fermentation process, oxygen supply rate is 25-30mmol/h, oxygen concentration 1500-1800g/
m3.It is supplied oxygen using above-mentioned condition, can either ensure can be into logical oxygen condition Bacillus cercus and bacillus subtilis
Row aerobic fermentation promotes the growth of bacterium, promotes its decomposition to substance in dry moutan bark, convenient for activity in later stage dry moutan bark
The dissolution of ingredient, and the intracutaneous harmful substance of tree peony is decomposed, reduce harmful substance contents.
One layer of S4, package coating agent；
The intracutaneous active material of tree peony is easier to dissolve out after fermentation, its storage time has been greatly shortened, and is also unfavorable for ensureing
The stabilization of the property of moutan bark, therefore, in order to solve outside the dry moutan bark of this technical problem embodiment of the present invention after fermentation
One layer of coating agent is wrapped up, coating agent, which is wrapped in outside moutan bark, can prevent the intracutaneous active constituent of tree peony from overflowing, and extend moutan bark
Quality guarantee period.
Specifically, the coating agent and the dry moutan bark are mixed 3-5 minutes under the conditions of 35-40 DEG C.Package
Agent is honey.First by honey, moutan bark is then put into and wherein mixes by enduring at 35-40 DEG C so that every moutan bark surface is equal
One layer of honey can be wrapped up.The mixing of honey and moutan bark is can not be long, prevents honey from entering in moutan bark, and prevent bee
It is to cause honey to change colour and go bad by long that honey, which decocts,.Honey is boiled simultaneously and mixed temperature is unsuitable excessively high, equally
It is rotten to easily cause honey, and reduces package effect.
Meanwhile 10 to ten/20ths 1/5th that the additive amount of honey is moutan bark dosage, using aforementioned proportion
Honey can ensure uniformly to wrap up honey outside moutan bark, and honey thickness is 1-3 millimeters, if honey usage amount is excessive, is easy
Cause the outer honey layer thickness of moutan bark blocked up, the intracutaneous active constituent of tree peony is then caused to be not easy to dissolve out or extend in moutan bark
The time of active constituent dissolution.And if honey usage amount is very few, and good package cannot be carried out to moutan bark, therefore, uses
Above-mentioned honey can either ensure to wrap up the dissolution that effect can guarantee active constituent in follow-up moutan bark again.
Meanwhile using honey, honey can improve the taste of moutan bark, and eliminate the side effect of tree peony skin portion, be promoted
The therapeutic effect of moutan bark.
The embodiment of the present invention also provides a kind of moutan bark, and the processing procedure through above-mentioned moutan bark is made.
Embodiment 1
The present embodiment provides a kind of processing procedures of moutan bark comprising following steps：
S1, pretreatment；
Fresh moutan bark of the buying without no insect pest fresh high-quality of going mouldy, the moutan bark purchased back is cleaned.It will cleaning
Fresh moutan bark afterwards is placed in temperature and is 25 DEG C, air-dries in the environment of humidity is 10%.Then the moutan bark after air-drying is sliced
Processing obtains dry moutan bark.
S2, it fumigates；
Ethyl alcohol is heated so that alcohol vapour and the effect of dry moutan bark are 5 minutes stifling, are then lyophilized.
S3, fermentation；
Sterilization processing is carried out to the dry moutan bark after freeze-drying, irradiates dry moutan bark 0.5 hour using using ultraviolet light, irradiation
Distance is 0.8 meter, and uitraviolet intensity is 250 μ W/cm3.Microbial bacterial agent then is sprayed on the dry moutan bark surface, has been sprayed
It is dried after.
Every milliliter of microbial bacterial agent includes 5 × 109A bacillus composition, wherein bacillus composition master
According to mass ratio to be 1.2 by Bacillus cercus and bacillus subtilis：1 quantity ratio is mixed.Fermentation is in temperature
It ferments 12 hours under conditions of being 85% for 37 DEG C and humidity.It is also supplied oxygen in fermentation process, oxygen supply rate is 30mmol/h, oxygen
A concentration of 1800g/m3。
One layer of S4, package coating agent；
Described one layer of coating agent of dry moutan bark outer wrapping after fermentation.Wherein, coating agent is honey, coating agent and tree peony
The temperature of skin mixing is 40 DEG C, and the time is 3 minutes, and the additive amount of honey is 1st/15th of moutan bark dosage, honey thickness
It is 1-3 millimeters.
The embodiment of the present invention also provides a kind of moutan bark, and the processing procedure through above-mentioned moutan bark is made.
Embodiment 2
The present embodiment provides a kind of processing procedures of moutan bark comprising following steps：
S1, pretreatment；
Fresh moutan bark of the buying without no insect pest fresh high-quality of going mouldy, the moutan bark purchased back is cleaned.It will cleaning
Fresh moutan bark afterwards is placed in temperature and is 30 DEG C, air-dries in the environment of humidity is 18%.Then the moutan bark after air-drying is sliced
Processing obtains dry moutan bark.
S2, it fumigates；
Dichlorodiphenyl Acetate is heated so that acetic acid steam and the effect of dry moutan bark are 15 minutes stifling, are then lyophilized.
S3, fermentation；
Sterilization processing is carried out to the dry moutan bark after freeze-drying, irradiates dry moutan bark 1 hour using using ultraviolet light, irradiation away from
From being 0.5 meter, uitraviolet intensity is 220 μ W/cm3.Microbial bacterial agent then is sprayed on the dry moutan bark surface, sprinkling is completed
After dry.
Every milliliter of microbial bacterial agent includes 8 × 109A bacillus composition, wherein bacillus composition master
According to mass ratio to be 1.5 by Bacillus cercus and bacillus subtilis：1 quantity ratio is mixed.Fermentation is in temperature
It ferments 6 hours under conditions of being 75% for 35 DEG C and humidity.It is also supplied oxygen in fermentation process, oxygen supply rate is 25mmol/h, oxygen
A concentration of 1500g/m3。
One layer of S4, package coating agent；
Described one layer of coating agent of dry moutan bark outer wrapping after fermentation.Wherein, coating agent is honey, coating agent and tree peony
The temperature of skin mixing is 35 DEG C, and the time is 5 minutes, and the additive amount of honey is 1st/20th of moutan bark dosage, honey thickness
It is 1-2 millimeters.
The embodiment of the present invention also provides a kind of moutan bark, by processing procedure system of the fresh moutan bark through above-mentioned moutan bark
.
Embodiment 3
The present embodiment provides a kind of processing procedures of moutan bark comprising following steps：
S1, pretreatment；
Fresh moutan bark of the buying without no insect pest fresh high-quality of going mouldy, the moutan bark purchased back is cleaned.It will cleaning
Fresh moutan bark afterwards is placed in temperature and is 28 DEG C, air-dries in the environment of humidity is 15%.Then the moutan bark after air-drying is sliced
Processing obtains dry moutan bark.
S2, processing；
Ethanedioic acid is heated so that ethanedioic acid steam and the effect of dry moutan bark are 10 minutes stifling, are then lyophilized.
S3, fermentation；
Sterilization processing is carried out to the dry moutan bark after freeze-drying, irradiates dry moutan bark 0.7 hour using using ultraviolet light, irradiation
Distance is 0.6 meter, and uitraviolet intensity is 200 μ W/cm3.Microbial bacterial agent then is sprayed on the dry moutan bark surface, has been sprayed
It is dried after.
Every milliliter of microbial bacterial agent includes 7 × 109A bacillus composition, wherein bacillus composition master
According to mass ratio to be 1.3 by Bacillus cercus and bacillus subtilis：1 quantity ratio is mixed.Fermentation is in temperature
It ferments 10 hours under conditions of being 80% for 36 DEG C and humidity.It is also supplied oxygen in fermentation process, oxygen supply rate is 28mmol/h, oxygen
A concentration of 1700g/m3。
One layer of S4, package coating agent；
Described one layer of coating agent of dry moutan bark outer wrapping after fermentation.Wherein, coating agent is honey, coating agent and tree peony
The temperature of skin mixing is 37 DEG C, and the time is 4 minutes, and the additive amount of honey is 1st/17th of moutan bark dosage, honey thickness
It is 1.5-2.5 millimeters.
The embodiment of the present invention also provides a kind of moutan bark, by processing procedure system of the fresh moutan bark through above-mentioned moutan bark
.
Embodiment 4
The present embodiment provides a kind of processing procedures of moutan bark comprising following steps：
S1, pretreatment；
Fresh moutan bark of the buying without no insect pest fresh high-quality of going mouldy, the moutan bark purchased back is cleaned.It will cleaning
Fresh moutan bark afterwards is placed in temperature and is 27 DEG C, air-dries in the environment of humidity is 13%.Then the moutan bark after air-drying is sliced
Processing obtains dry moutan bark.
S2, processing；
Formic acid is heated so that formic acid vapor and the effect of dry moutan bark are 8 minutes stifling, are then lyophilized.
S3, fermentation；
Sterilization processing is carried out to the dry moutan bark after freeze-drying, irradiates dry moutan bark 0.8 hour using using ultraviolet light, irradiation
Distance is 0.7 meter, and uitraviolet intensity is 235 μ W/cm3.Microbial bacterial agent then is sprayed on the dry moutan bark surface, has been sprayed
It is dried after.
Every milliliter of microbial bacterial agent includes 6.5 × 109A bacillus composition, wherein bacillus composition
It is mainly 1.4 according to mass ratio by Bacillus cercus and bacillus subtilis：1 quantity ratio is mixed.Fermentation is in temperature
Degree for 36.5 DEG C and humidity be 78% under conditions of ferment 8 hours.It also being supplied oxygen in fermentation process, oxygen supply rate is 27mmol/h,
Oxygen concentration is 1600g/m3。
One layer of S4, package coating agent；
Described one layer of coating agent of dry moutan bark outer wrapping after fermentation.Wherein, coating agent is honey, coating agent and tree peony
The temperature of skin mixing is 39 DEG C, and the time is 4 minutes, and the additive amount of honey is 1st/15th of moutan bark dosage, honey thickness
It is 1-1.5 millimeters.
The embodiment of the present invention also provides a kind of moutan bark, by processing procedure system of the fresh moutan bark through above-mentioned moutan bark
.
Comparative example 1
Same amount of moutan bark is processed in the way of embodiment 1, difference lies in the moutan bark used is to be fresh without wind
Dry moutan bark.
Comparative example 2
Same amount of moutan bark is processed in the way of embodiment 1, difference lies in, only fumigated, and without follow-up
Fermentation and package.
Comparative example 3
Same amount of moutan bark is processed in the way of embodiment 1, difference lies in, it is not fumigated, and directly sent out
Ferment and coating agent package.
Comparative example 4
Moutan bark is obtained using natural drying in the prior art.
Experimental example
The moutan bark (10g) of same size, same thickness, the comparative example 1-4 of phase homogenous quantities and embodiment 1-4 are taken respectively,
Then respectively moutan bark decoct 30 minutes under conditions of 65 DEG C, using high-efficient liquid phase analysis measurement decoct 10 minutes,
20 minutes and 30 minutes are the amounts (mg) for extracting obtained Paeonol.Specific testing result is referring to table 1.
1 testing result of table
| 10 minutes (mg) | 20 minutes (mg) | 30 minutes (mg) | |
| Embodiment 1 | 87 | 106 | 135 |
| Embodiment 2 | 94 | 117 | 149 |
| Embodiment 3 | 90 | 109 | 151 |
| Embodiment 4 | 96 | 116 | 157 |
| Comparative example 1 | 70 | 86 | 92 |
| Comparative example 2 | 40 | 52 | 66 |
| Comparative example 3 | 67 | 79 | 88 |
| Comparative example 4 | 32 | 44 | 51 |
According to the result of table 1 it is found that the moutan bark prepared using technique provided in an embodiment of the present invention is active in 10min
Ingredient stripping quantity is very big, is 3 times of conventional processing procedure (comparative example 4), if the processing procedure of the change present invention, when identical
The active constituent stripping quantity of interior moutan bark is greatly lowered, for example, when 20min and 30min comparative example 1-3 active constituent
Stripping quantity only have the half of the present invention substantially or less than half, illustrate that the concocting method that the embodiment of the present invention provides is promoted
The stripping quantity and dissolution rate of moutan bark active constituent.
In conclusion a kind of processing procedure of moutan bark provided by the invention is due to by moutan bark wind under suitable conditions
It is dry, surface disinfection is carried out after air-drying, and is killed the mould on moutan bark surface, is effectively prevent subsequent fermentations moutan bark mouldy, so
Moutan bark surface mould is further suppressed using the microbial bacterial agent sprinkling moutan bark surface containing appropriate concentration bacillus afterwards
Growth, and the various enzymes of secreted from bacillus can promote moutan bark to ferment, and reduce the content of harmful substance in moutan bark, favorably
In the dissolution of moutan bark active constituent, then wrapping up one layer of coating agent can prevent the intracutaneous active constituent of tree peony in the mistake of storage
It is dissolved out in journey, extends its shelf-life.
The foregoing is merely the preferred embodiment of the present invention, are not intended to restrict the invention, for this field
For technical staff, the invention may be variously modified and varied.All within the spirits and principles of the present invention, any made by
Modification, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of processing procedure of moutan bark, which is characterized in that include the following steps：
After being fumigated 5-10 minutes using solvent to dry moutan bark again after the dry moutan bark surface injection microbial bacterial agent in temperature
Degree be 35-37 DEG C with humidity be 75-85% under conditions of ferment 6-12 hours, then again in one layer of the dry moutan bark outer wrapping
Coating agent；
Wherein, every milliliter of microbial bacterial agent includes 5 × 109~8 × 109A bacillus composition；The bacillus group
It is 1.2-1.5 according to mass ratio by Bacillus cercus and bacillus subtilis to close object mainly：1 quantity ratio is mixed.
2. the processing procedure of moutan bark according to claim 1, which is characterized in that it is to add the solvent to be steamed using solvent
The vapor action formed after heat is in the dry moutan bark.
3. the processing procedure of moutan bark according to claim 2, which is characterized in that the solvent is alcohols material or carboxylic acid
Substance, the alcohols material are monohydric alcohol, preferably C1-C4 monohydric alcohols, more preferably C1-C2 monohydric alcohols；
The carboxylic-acid substance is monoacid or binary acid, and the preferably described monoacid is C1-C3 monoacid, more preferably acetic acid；
It is preferred that the binary acid is C4-C10 binary acid, more preferably ethanedioic acid.
4. the processing procedure of moutan bark according to claim 1, which is characterized in that micro- in the dry moutan bark surface injection
Sterilization processing is carried out to the dry moutan bark before bacteria agent.
5. the processing procedure of moutan bark according to claim 4, which is characterized in that sterilization processing is irradiated using ultraviolet light
Described dry moutan bark 0.5-1 hours, irradiation distance was 0.5-0.8 meters.
6. the processing procedure of moutan bark according to claim 1, which is characterized in that persistently supply oxygen, supply oxygen in fermentation process
Rate is 25-30mmol/h, oxygen concentration 1500-1800g/m3。
7. the processing procedure of moutan bark according to claim 6, which is characterized in that in one layer of the dry moutan bark outer wrapping
The coating agent is that the coating agent and the dry moutan bark are mixed 3-5 minutes under the conditions of 35-40 DEG C.
8. the processing procedure of moutan bark according to claim 7, which is characterized in that the coating agent is honey.
9. the processing procedure of moutan bark according to claim 1, which is characterized in that the dry moutan bark is by fresh acquisition
Moutan bark afterwards cleans up the moutan bark for air-drying and being sliced and obtaining.
10. a kind of moutan bark, which is characterized in that its processing procedure through claim 1-9 any one of them moutan barks is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810509118.5A CN108354978A (en) | 2018-05-24 | 2018-05-24 | Moutan bark and its processing procedure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810509118.5A CN108354978A (en) | 2018-05-24 | 2018-05-24 | Moutan bark and its processing procedure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108354978A true CN108354978A (en) | 2018-08-03 |
Family
ID=63012494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810509118.5A Pending CN108354978A (en) | 2018-05-24 | 2018-05-24 | Moutan bark and its processing procedure |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108354978A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109091544A (en) * | 2018-09-28 | 2018-12-28 | 安徽汇中州中药饮片有限公司 | Cortex moutan process of preparing technique |
| CN110882172A (en) * | 2019-12-13 | 2020-03-17 | 临沂市食品药品检验检测中心 | Paeonol-containing multi-effect hair care shampoo and preparation method thereof |
| CN111297733A (en) * | 2019-12-13 | 2020-06-19 | 菏泽学院 | Paeonol-containing high-moisture-retention sun-screening agent and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107625829A (en) * | 2017-10-13 | 2018-01-26 | 河南省三禾药业有限公司 | A kind of dried orange peel and its urge ageing process |
-
2018
- 2018-05-24 CN CN201810509118.5A patent/CN108354978A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107625829A (en) * | 2017-10-13 | 2018-01-26 | 河南省三禾药业有限公司 | A kind of dried orange peel and its urge ageing process |
Non-Patent Citations (3)
| Title |
|---|
| （德）鲍尔: "《药物制剂包衣原理工艺及设备》", 30 April 2006, 中国医药科技出版社 * |
| 乔延江: "《中药制剂学》", 30 April 2017, 中国协和医科大学出版社 * |
| 夏家超: "丹皮的生产技术", 《农家科技》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109091544A (en) * | 2018-09-28 | 2018-12-28 | 安徽汇中州中药饮片有限公司 | Cortex moutan process of preparing technique |
| CN110882172A (en) * | 2019-12-13 | 2020-03-17 | 临沂市食品药品检验检测中心 | Paeonol-containing multi-effect hair care shampoo and preparation method thereof |
| CN111297733A (en) * | 2019-12-13 | 2020-06-19 | 菏泽学院 | Paeonol-containing high-moisture-retention sun-screening agent and preparation method thereof |
| CN110882172B (en) * | 2019-12-13 | 2023-10-10 | 临沂科技职业学院 | Multi-effect hair care shampoo containing paeonol and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108354978A (en) | Moutan bark and its processing procedure | |
| EP3938487A1 (en) | Mycelium biopolymers for health and beauty applications | |
| CN109329609A (en) | One kind containing mint flavored composite essential oil and feed addictive and application | |
| KR20170141497A (en) | Herbal Shampoo Manufacturing Method using Enzyme Extract Fluid of Chinese Medicine and Dendropanax morbifera Lev | |
| CN106311720A (en) | Harmless treatment method for pigs dead due to illness | |
| CN107625829A (en) | A kind of dried orange peel and its urge ageing process | |
| CN105148316B (en) | A kind of sterile adhesive bandage of zinc-base montmorillonite and its preparation method and application | |
| CN104984098B (en) | A kind of method of sauce incense liquor vinasse production bath foot powder | |
| CN106491415A (en) | A kind of pox-eliminating whitening concealer and preparation method thereof | |
| KR100879051B1 (en) | Pharmaceutical composition for treating athlete's foot | |
| KR20100126110A (en) | Manufacturing method for medicinal wine using turmeic thereof medicinal wine | |
| CN111184674A (en) | Oral care agent for superficial wound care and application method thereof | |
| CN105494461A (en) | Reagent for preventing and curing apple-tree valsa canker | |
| KR100619508B1 (en) | Manufacturing method of combustion and bath material of moxibustion and incense using lead | |
| CN112717076A (en) | Ointment for treating onychomycosis and preparation method thereof | |
| CN110330431A (en) | Utilize the method for husky ginger oil extract waste liquid preparation mosquito repellant | |
| CN111972491A (en) | Method for slowing down storage consumption of oil tea fruit oil | |
| CN107164144B (en) | Preparation method of cordyceps militaris and penis cervi wine | |
| CN108719350A (en) | Sunstroke prevention mosquito-repellent essential oil and preparation method thereof and application method | |
| CN109528754A (en) | Composition, externally applied drug, preparation method and its application for treating the externally applied drug of inner cavity mucosal inflammation | |
| CN109362788A (en) | A kind of graininess anti-mite agent and its application | |
| KR101394957B1 (en) | a fermentation red ginseng process | |
| CN106381255A (en) | Preparation process of Tibetan medicine highland barley wine starter | |
| CN113116764A (en) | Michelia figo skin care product and preparation method thereof | |
| CN108354979A (en) | Radix Paeoniae Alba and its processing procedure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180803 |
|
| RJ01 | Rejection of invention patent application after publication |