CN108348479A - 靶向甲酰肽受体2/脂氧素a4受体(fpr2/alx)以用于治疗心脏疾病 - Google Patents

靶向甲酰肽受体2/脂氧素a4受体(fpr2/alx)以用于治疗心脏疾病 Download PDF

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Publication number
CN108348479A
CN108348479A CN201680068442.7A CN201680068442A CN108348479A CN 108348479 A CN108348479 A CN 108348479A CN 201680068442 A CN201680068442 A CN 201680068442A CN 108348479 A CN108348479 A CN 108348479A
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CN
China
Prior art keywords
alx
fpr2
treatment
receptor
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201680068442.7A
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English (en)
Chinese (zh)
Inventor
J.奥斯特罗夫斯基
R.加西亚
N.R.维尔茨
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CN108348479A publication Critical patent/CN108348479A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201680068442.7A 2015-11-24 2016-11-21 靶向甲酰肽受体2/脂氧素a4受体(fpr2/alx)以用于治疗心脏疾病 Pending CN108348479A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562259498P 2015-11-24 2015-11-24
US62/259498 2015-11-24
PCT/US2016/063036 WO2017091496A1 (en) 2015-11-24 2016-11-21 Targeting of the formyl-peptide receptor 2/lipoxin a4 receptor (fpr2/alx) for treatment of heart disease

Publications (1)

Publication Number Publication Date
CN108348479A true CN108348479A (zh) 2018-07-31

Family

ID=57544530

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680068442.7A Pending CN108348479A (zh) 2015-11-24 2016-11-21 靶向甲酰肽受体2/脂氧素a4受体(fpr2/alx)以用于治疗心脏疾病

Country Status (13)

Country Link
US (1) US20180325869A1 (https=)
EP (1) EP3380091A1 (https=)
JP (1) JP2018538367A (https=)
KR (1) KR20180081528A (https=)
CN (1) CN108348479A (https=)
AU (1) AU2016359463A1 (https=)
BR (1) BR112018010155A8 (https=)
CA (1) CA3006291A1 (https=)
EA (1) EA201891007A1 (https=)
IL (1) IL259468A (https=)
MX (1) MX2018005756A (https=)
SG (1) SG11201803816RA (https=)
WO (1) WO2017091496A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3414227B1 (en) 2015-12-10 2021-11-24 Bristol-Myers Squibb Company Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
KR102623473B1 (ko) 2017-06-09 2024-01-09 브리스톨-마이어스 스큅 컴퍼니 피페리디논 포르밀 펩티드 2 수용체 및 포르밀 펩티드 1 수용체 효능제
WO2018227067A1 (en) 2017-06-09 2018-12-13 Bristol-Myers Squibb Company Cyclopropyl urea formyl peptide 2 receptor and formyl peptide 1 receptor agonists
CN110997653B (zh) 2017-06-09 2023-06-06 百时美施贵宝公司 芳基杂环哌啶酮甲酰肽2受体和甲酰肽1受体激动剂
US11008301B2 (en) 2017-06-09 2021-05-18 Bristol-Myers Squibb Company Piperidinone formyl peptide 2 receptor agonists
US10676431B2 (en) 2018-03-05 2020-06-09 Bristol-Myers Squibb Company Phenylpyrrolidinone formyl peptide 2 receptor agonists
CN113166134B (zh) 2018-11-26 2024-06-14 百时美施贵宝公司 作为甲酰肽2受体激动剂的吡咯烷酮衍生物
IL299680A (en) 2020-07-09 2023-03-01 Bristol Myers Squibb Co Pyrazolone formyl peptide 2 receptor agonists
JP7802765B2 (ja) 2020-08-12 2026-01-20 ブリストル－マイヤーズ スクイブ カンパニー オキソピロリジン尿素ｆｐｒ２アゴニスト

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103221392A (zh) * 2010-11-17 2013-07-24 埃科特莱茵药品有限公司 桥联螺[2.4]庚酯衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2492167C2 (ru) * 2007-12-18 2013-09-10 Актелион Фармасьютиклз Лтд Производные аминотриазола в качестве агонистов alх
CA2871334A1 (en) * 2012-05-16 2013-11-21 Actelion Pharmaceuticals Ltd 1-(p-tolyl)cyclopropyl substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists
EP3414227B1 (en) * 2015-12-10 2021-11-24 Bristol-Myers Squibb Company Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
US10676431B2 (en) * 2018-03-05 2020-06-09 Bristol-Myers Squibb Company Phenylpyrrolidinone formyl peptide 2 receptor agonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103221392A (zh) * 2010-11-17 2013-07-24 埃科特莱茵药品有限公司 桥联螺[2.4]庚酯衍生物

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHENGXUE QIN, ET AL.: "Cardioprotective potential of annexin-A1 mimetics in myocardial infarction", 《PHARMACOLOGY & THERAPEUTICS》 *
HUAMEI FORSMAN, ET AL.: "Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library", 《BIOCHEMICAL PHARMACOLOGY》 *
JESMOND DALLI, ET AL.: "Proresolving and Tissue-Protective Actions of Annexin A1–Based Cleavage-Resistant Peptides Are Mediated by Formyl Peptide Receptor 2/Lipoxin A4 Receptor", 《THE JOURNAL OF IMMUNOLOGY》 *
MARCELO H. PETRI , ET AL.: "The role of the FPR2/ALX receptor in atherosclerosis development and plaque stability", 《CARDIOVASCULAR RESEARCH》 *
THOMAS GOBBETTI, ET AL.: "Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis", 《PNAS》 *
VASUNDHARA KAIN, ET AL.: "Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function", 《JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY》 *

Also Published As

Publication number Publication date
US20180325869A1 (en) 2018-11-15
KR20180081528A (ko) 2018-07-16
CA3006291A1 (en) 2017-06-01
EP3380091A1 (en) 2018-10-03
BR112018010155A8 (pt) 2019-02-26
WO2017091496A1 (en) 2017-06-01
SG11201803816RA (en) 2018-06-28
MX2018005756A (es) 2018-08-01
IL259468A (en) 2018-07-31
JP2018538367A (ja) 2018-12-27
EA201891007A1 (ru) 2018-11-30
AU2016359463A1 (en) 2018-07-12
BR112018010155A2 (pt) 2018-11-21

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Application publication date: 20180731