CN108341865A - A kind of novel equipment and method for preparing collagen - Google Patents
A kind of novel equipment and method for preparing collagen Download PDFInfo
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- CN108341865A CN108341865A CN201810482169.3A CN201810482169A CN108341865A CN 108341865 A CN108341865 A CN 108341865A CN 201810482169 A CN201810482169 A CN 201810482169A CN 108341865 A CN108341865 A CN 108341865A
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 155
- 108010035532 Collagen Proteins 0.000 title claims abstract description 155
- 229920001436 collagen Polymers 0.000 title claims abstract description 153
- 238000000034 method Methods 0.000 title claims abstract description 19
- 239000008280 blood Substances 0.000 claims abstract description 80
- 210000004369 blood Anatomy 0.000 claims abstract description 79
- 238000002360 preparation method Methods 0.000 claims abstract description 28
- 238000000746 purification Methods 0.000 claims abstract description 26
- 238000010241 blood sampling Methods 0.000 claims abstract description 21
- 210000003743 erythrocyte Anatomy 0.000 claims description 16
- 210000001772 blood platelet Anatomy 0.000 claims description 15
- 210000002381 plasma Anatomy 0.000 claims description 15
- 239000002994 raw material Substances 0.000 claims description 15
- 238000004587 chromatography analysis Methods 0.000 claims description 8
- 238000003860 storage Methods 0.000 claims description 7
- 239000003292 glue Substances 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000004471 Glycine Substances 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000003862 amino acid derivatives Chemical class 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of novel equipment for preparing collagen, the equipment includes blood sampling unit, blood taking bag, whole blood separator, collagen preparation unit, collagen purification unit, collagen reservoir bag, and the blood sampling unit is connected with blood taking bag by conduit；The input port of the whole blood separator is connect by conduit with blood taking bag, and the delivery outlet of the whole blood separator is connect by conduit with collagen preparation unit；The input port of the collagen purification unit is connect by conduit with collagen preparation unit, and the delivery outlet of the collagen purification unit is connect by conduit with collagen reservoir bag.By using above-mentioned technical proposal, the equipment for manufacturing collagen that a kind of preparation process is simple, easy to make is provided.The invention also discloses the methods for preparing collagen using the above-mentioned novel equipment for preparing collagen.
Description
Technical field
The present invention relates to collagen technical fields, and in particular to a kind of novel equipment for preparing collagen and side
Method.
Background technology
Collagen is a dominant structural moieties of human body, be primarily present in connective tissue-body protein
30% is collagen.The amino acid sequence of collagen is very characteristic, rich in glycine and proline and amino acid
Derivative.For most protein containing only a small amount of glycine, collagen is an important exception, its sweet ammonia containing one third
The oxylysine that rare hydroxyproline, pyroglutamic acid and other protein there's almost no in acid, and general albumen.It grinds
Study carefully show glycine digestion and central nervous system function on, improve body using antioxidant efficiency so that help
In slowing down bodily tissue aging, play an important role on young body of keeping fit.It is therefore seen that collagen nutritive value is rich
Richness, and the collagen with 5 high-purity, high density, high activity, high-absorbility, high conversion dimensions is best collagen
Albumen.
But the collagen that people buy or use in the prior art comes from plant either animal mostly, very
The rare human body of arising directly from.
Invention content
It is in the prior art to solve the purpose of the present invention is to provide a kind of novel equipment for preparing collagen
Collagen is from the problem of plant or animal.
To achieve the above object, the technical scheme is that：
A kind of novel equipment for preparing collagen, the equipment include blood sampling unit, blood taking bag, whole blood separator,
Collagen preparation unit, collagen purification unit, collagen reservoir bag, the blood sampling unit and blood taking bag pass through conduit
Connection；The input port of the whole blood separator is connect by conduit with blood taking bag, and the delivery outlet of the whole blood separator is by leading
Pipe is connect with collagen preparation unit；The input port of the collagen purification unit is prepared single by conduit and collagen
Member connection, the delivery outlet of the collagen purification unit are connect by conduit with collagen reservoir bag.
As a preferred solution, the equipment further includes blood plasma collecting bag, the blood plasma collecting bag by conduit with
Another delivery outlet of whole blood separator connects.
As a preferred solution, the collagen preparation unit includes that red blood cell prepares collagen unit, blood
Platelet prepares collagen unit and tunica albuginea prepares collagen unit.
As a preferred solution, collagen purification unit includes chromatography unit and filter unit, and the chromatography is single
The collagen that member is exported for preliminary purification from collagen preparation unit, the filter unit is for being further purified from layer
Analyse the collagen of unit output.
As a preferred solution, the blood sampling unit includes blood taking needle.
Second object of the present invention is to provide a kind of utilization novel equipment system for preparing collagen as described above
The method of standby collagen, described method includes following steps：
Step 1：Using blood sampling unit, to human body, blood was collected, by blood storage in blood taking bag；
Step 2：Blood is imported from blood taking bag in whole blood separator, each ingredient of blood is detached, is made
The raw material of standby collagen；
Step 3：The raw material for preparing collagen is imported into collagen preparation unit, collagen is prepared；
Step 4：The collagen being prepared is entered into collagen purification unit, carries out Purified collagen；
Step 5：The collagen that purifying obtains is stored in collagen reservoir bag.
As a preferred solution, the method further includes following steps：
Step 6：The blood plasma isolated from whole blood separator is stored in blood plasma collecting bag, it is finally defeated to return to human body
It is interior.
As a preferred solution, the raw material for the collagen being prepared includes red blood cell, blood platelet and tunica albuginea, is divided
Not Jin Ru red blood cell prepares collagen unit, blood platelet prepares collagen unit and tunica albuginea prepares collagen unit, point
Corresponding collagen is not prepared, then respectively enters corresponding collagen purification unit and is purified.
The invention has the advantages that：
The novel equipment for preparing collagen provided by the invention includes blood sampling unit, blood taking bag, whole blood separator, glue
Former albumen preparation unit, collagen purification unit, collagen reservoir bag.Glue is directly prepared from blood of human body in the equipment
Former albumen is the equipment for manufacturing collagen that a kind of preparation process is simple, easy to make.Equipment complex autogenous cell increasing
Plantation technology, autologous skin Stem cells cultured in vitro reinject technology, hyaluronic acid and collagen technology, autologous collagen albumen with
The extension of time is gradually absorbed, while the fibroblast survived starts continuously to generate self collagen,
So that the thickness and density of skin layers is increased, to repair wrinkle or depressed scar, restore skin elasticity, toughness and gloss,
Reach cosmetic result at a specified future date.
Description of the drawings
Fig. 1 is the structural schematic diagram of the embodiment of the present invention 1.
The structural schematic diagram of Fig. 2 the embodiment of the present invention 2.
Wherein, 1- blood samplings unit, 1-1- blood taking needles, 2- blood taking bags, 3- whole blood separators, 4- collagen preparation units,
5- collagen purification units, 6- collagen reservoir bags, 7- blood plasma collecting bags, 8- tunica albuginea collecting bags, 9- Thrombocyte collecting bags,
10- red blood cell bags.
Specific implementation mode
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Embodiment 1
The present embodiment provides a kind of novel equipment for preparing collagen, as shown in Figure 1, the equipment includes that blood sampling is single
Member 1, blood taking bag 2, whole blood separator 3, collagen preparation unit 4, collagen purification unit 5, collagen reservoir bag 6,
The blood sampling unit is connected with blood taking bag by conduit；The input port of the whole blood separator is connect by conduit with blood taking bag,
The delivery outlet of the whole blood separator is connect by conduit with collagen preparation unit；The collagen purification unit it is defeated
Entrance is connect by conduit with collagen preparation unit, and the delivery outlet of the collagen purification unit passes through conduit and collagen
Protein storage bag connects.
The equipment further includes blood plasma collecting bag 7, and the blood plasma collecting bag passes through another of conduit and whole blood separator
Delivery outlet connects.
The collagen preparation unit includes that red blood cell prepares collagen unit, blood platelet prepares collagen unit
Collagen unit is prepared with tunica albuginea.
Collagen purification unit includes chromatography unit and filter unit, and the chromatography unit is used for preliminary purification from collagen
The collagen of albumen preparation unit output, the filter unit is for being further purified the collagen egg exported from chromatography unit
In vain.
The blood sampling unit includes blood taking needle 1-1.
The method for preparing collagen using the above-mentioned novel equipment for preparing collagen, the method includes as follows
Step：
Step 1：Using blood sampling unit, to human body, blood was collected, by blood storage in blood taking bag；
Step 2：Blood is imported from blood taking bag in whole blood separator, each ingredient of blood is detached, is made
The raw material of standby collagen；
Step 3：The raw material for preparing collagen is imported into collagen preparation unit, collagen is prepared；
Step 4：The collagen being prepared is entered into collagen purification unit, carries out Purified collagen；
Step 5：The collagen that purifying obtains is stored in collagen reservoir bag.
The method further includes following steps：
Step 6：The blood plasma isolated from whole blood separator is stored in blood plasma collecting bag, it is finally defeated to return to human body
It is interior.
The raw material for the collagen being prepared includes red blood cell, blood platelet and tunica albuginea, respectively enters red blood cell and prepares glue
Former protein unit, blood platelet prepare collagen unit and tunica albuginea prepares collagen unit, are prepared respectively corresponding
Then collagen respectively enters corresponding collagen purification unit and is purified.
To prepare collagen required molten for acquisition from circulation storage room by being coupled component for collagen preparation unit
Liquid.The circulation storage room is temperature control, for maintaining solution required temperature.
The specific preparation process of collagen preparation unit belongs to the prior art, and details are not described herein.
Embodiment 2
The present embodiment provides a kind of equipment of novel extraction red blood cell, as shown in Fig. 2, the equipment includes blood sampling unit
1, blood taking bag 1, whole blood separator 3, red blood cell bag 10, Thrombocyte collecting bag 9, tunica albuginea collecting bag 8.The blood sampling unit and
Blood taking bag is connected by conduit；The input port of the whole blood separator is connect by conduit with blood taking bag.Raw material collecting bag includes
There is the tunica albuginea collecting bag, Thrombocyte collecting bag and red blood cell bag be connected respectively with blood taking bag；Whole blood separator includes two
A output end, one of whole blood separator output end are connected by main pipe with Thrombocyte collecting bag, are set on the main pipe
There is point conduit to be connected with tunica albuginea collecting bag, another output end of blood taking bag is connected by main pipe with blood plasma collecting bag, this is leading
Pipe is equipped with divides conduit with what red blood cell bag was connected.
The blood sampling unit includes blood taking needle 1-1.
The method for preparing collagen using the above-mentioned novel equipment for preparing collagen, the method includes as follows
Step：
Step 1：Using blood sampling unit, to human body, blood was collected, by blood storage in blood taking bag；
Step 2：Blood is imported from blood taking bag in whole blood separator, each ingredient of blood is detached, is made
The raw material of standby collagen；
Step 3：The raw material for preparing collagen is stored in raw material collecting bag；
The raw material for the collagen being prepared includes red blood cell, blood platelet and tunica albuginea, is separately stored in red blood cell
In bag, Thrombocyte collecting bag and tunica albuginea collecting bag.
The method further includes following steps：
Step 4：The blood plasma isolated from whole blood separator is stored in blood plasma collecting bag, it is finally defeated to return to human body
It is interior.
After above-mentioned preparation process, the substance taking-up in raw material collecting bag is matched and just completes collagen
It prepares.Preparation process is simple, and easy to make.It, should and by acquiring self-blood, and by preparing collagen in blood
Equipment complex autogenous cell multiplication technique, autologous skin Stem cells cultured in vitro reinject technology, hyaluronic acid and collagen egg
White technology, the fibroblast that the extension of autologous collagen albumen at any time is gradually absorbed, while survived start in a steady stream not
It is produced from body collagen disconnectedly, the thickness and density of skin layers is made to increase, to repair wrinkle or depressed scar, restores
Skin elasticity, toughness and gloss reach cosmetic result at a specified future date.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention belong to the scope of protection of present invention.
Claims (8)
1. a kind of novel equipment for preparing collagen, the equipment includes blood sampling unit, blood taking bag, whole blood separator, glue
Former albumen preparation unit, collagen purification unit, collagen reservoir bag, it is characterised in that：The blood sampling unit and blood sampling
Bag is connected by conduit；The input port of the whole blood separator is connect by conduit with blood taking bag, the whole blood separator it is defeated
Outlet is connect by conduit with collagen preparation unit；The input port of the collagen purification unit passes through conduit and collagen
Albumen preparation unit connects, and the delivery outlet of the collagen purification unit is connect by conduit with collagen reservoir bag.
2. the novel equipment for preparing collagen according to claim 1, which is characterized in that the equipment further includes blood
Collecting bag is starched, the blood plasma collecting bag is connect by conduit with another delivery outlet of whole blood separator.
3. the novel equipment for preparing collagen according to claim 1, which is characterized in that prepared by the collagen
Unit includes that red blood cell prepares collagen unit, blood platelet prepares collagen unit and tunica albuginea prepares collagen unit.
4. the novel equipment for preparing collagen according to claim 1, which is characterized in that collagen purification unit
Including chromatography unit and filter unit, the chromatography unit is used for the collagen egg that preliminary purification is exported from collagen preparation unit
In vain, the filter unit is for being further purified the collagen exported from chromatography unit.
5. the novel equipment for preparing collagen according to claim 1, which is characterized in that the blood sampling unit includes
Blood taking needle.
6. a kind of novel equipment for preparing collagen using described in any one of claim 1-5 prepares collagen
Method, which is characterized in that described method includes following steps：
Step 1：Using blood sampling unit, to human body, blood was collected, by blood storage in blood taking bag；
Step 2：Blood is imported from blood taking bag in whole blood separator, each ingredient of blood is detached, obtains preparing glue
The raw material of former albumen；
Step 3：The raw material for preparing collagen is imported into collagen preparation unit, collagen is prepared；
Step 4：The collagen being prepared is entered into collagen purification unit, carries out Purified collagen；
Step 5：The collagen that purifying obtains is stored in collagen reservoir bag.
7. the method that the novel equipment for preparing collagen according to claim 6 prepares collagen, feature exist
In the method further includes following steps：
Step 6：The blood plasma isolated from whole blood separator is stored in blood plasma collecting bag, it is finally defeated to return in human body.
8. the method that the novel equipment for preparing collagen according to claim 6 prepares collagen, feature exist
In the raw material for the collagen being prepared includes red blood cell, blood platelet and tunica albuginea, respectively enters red blood cell and prepares collagen
Unit, blood platelet prepare collagen unit and tunica albuginea prepares collagen unit, and corresponding collagen egg is prepared respectively
In vain, corresponding collagen purification unit is then respectively enterd to be purified.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810482169.3A CN108341865A (en) | 2018-05-18 | 2018-05-18 | A kind of novel equipment and method for preparing collagen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810482169.3A CN108341865A (en) | 2018-05-18 | 2018-05-18 | A kind of novel equipment and method for preparing collagen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108341865A true CN108341865A (en) | 2018-07-31 |
Family
ID=62956369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810482169.3A Pending CN108341865A (en) | 2018-05-18 | 2018-05-18 | A kind of novel equipment and method for preparing collagen |
Country Status (1)
| Country | Link |
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| CN (1) | CN108341865A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109078173A (en) * | 2018-08-27 | 2018-12-25 | 白晋 | A kind of consolidant comprising autologous collagen albumen and its application |
| CN109078172A (en) * | 2018-08-27 | 2018-12-25 | 白晋 | A kind of preparation and its application based on autologous tissue |
| CN109078220A (en) * | 2018-08-27 | 2018-12-25 | 白晋 | A kind of compound formulation comprising autologous collagen albumen and its application |
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| CN101157719A (en) * | 2007-11-01 | 2008-04-09 | 上海水产大学 | Method for separating and purifying molecule recombination collagen protein |
| CN101979410A (en) * | 2010-11-09 | 2011-02-23 | 白晋 | Equipment for preparing collagen |
| CN105481978A (en) * | 2016-02-19 | 2016-04-13 | 苏州微科天成生物技术有限公司 | Preparation method for high-purity collagen |
| CN111892652A (en) * | 2020-08-17 | 2020-11-06 | 马龙 | Apparatus for producing active collagen |
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2018
- 2018-05-18 CN CN201810482169.3A patent/CN108341865A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101157719A (en) * | 2007-11-01 | 2008-04-09 | 上海水产大学 | Method for separating and purifying molecule recombination collagen protein |
| CN101979410A (en) * | 2010-11-09 | 2011-02-23 | 白晋 | Equipment for preparing collagen |
| CN105481978A (en) * | 2016-02-19 | 2016-04-13 | 苏州微科天成生物技术有限公司 | Preparation method for high-purity collagen |
| CN111892652A (en) * | 2020-08-17 | 2020-11-06 | 马龙 | Apparatus for producing active collagen |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109078173A (en) * | 2018-08-27 | 2018-12-25 | 白晋 | A kind of consolidant comprising autologous collagen albumen and its application |
| CN109078172A (en) * | 2018-08-27 | 2018-12-25 | 白晋 | A kind of preparation and its application based on autologous tissue |
| CN109078220A (en) * | 2018-08-27 | 2018-12-25 | 白晋 | A kind of compound formulation comprising autologous collagen albumen and its application |
| CN113082289A (en) * | 2018-08-27 | 2021-07-09 | 白晋 | Composite preparation containing autologous collagen and application thereof |
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