CN108332506B - Plasma freeze-drying device - Google Patents

Plasma freeze-drying device Download PDF

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Publication number
CN108332506B
CN108332506B CN201711489961.3A CN201711489961A CN108332506B CN 108332506 B CN108332506 B CN 108332506B CN 201711489961 A CN201711489961 A CN 201711489961A CN 108332506 B CN108332506 B CN 108332506B
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inner barrel
barrel
filter screen
outer barrel
air inlet
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CN108332506B8 (en
CN108332506A (en
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赵洁
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First Affiliated Hospital of Medical College of Xian Jiaotong University
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    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25DREFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D31/00Other cooling or freezing apparatus
    • F25D31/002Liquid coolers, e.g. beverage cooler
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

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  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Drying Of Solid Materials (AREA)
  • External Artificial Organs (AREA)

Abstract

The invention provides a plasma freeze-drying device, which comprises an inner barrel, a blood storage column, an air inlet channel, an isolation valve, a condensation chamber and a vacuum pump, wherein the air inlet channel is arranged on the inner barrel; the outer barrel is sleeved on the outer side of the inner barrel through the top end of the inner barrel, the air inlet channel penetrates through the outer barrel and is communicated with the inner barrel, an active carbon filter screen, a nanofiber filter screen and a stainless steel filter screen are sequentially embedded in an inner cavity of the air inlet channel, the outer end of the Y-shaped channel is connected with a condensation chamber through an isolation valve respectively, the outer end side of the condensation chamber is connected with a refrigeration compressor through a pipeline, the vacuum pump is connected onto the Y-shaped channel in front of the isolation valve through a pipeline, and the bottom of the inner side of the outer barrel is provided with a spiral. The inner barrel is kept at a relatively constant temperature by using the spiral heating pipe, the vacuum pump is used for vacuumizing the inner barrel, the air in the inner barrel is replaced by the fan and the vacuum pump, the quality of the air in the inner barrel is improved, and the refrigeration compressor is used for freezing the plasma in the inner barrel.

Description

Plasma freeze-drying device
Technical Field
The invention belongs to the technical field of plasma freezing and medical equipment, and particularly relates to a plasma freezing and drying device.
Background
Lyophilization is the best method for preserving sensitive tissue of biological nature. The freeze dryer is suitable for drying bacteria, viruses, blood plasma, blood serum, antibodies, vaccines, and extracts of drugs, microorganisms, yeasts, and plants for biological research, and is capable of drying materials such as tissues, tissue extracts, bacteria, vaccines, and blood plasma by freeze drying, so that enzymatic, bacterial, and chemical changes do not occur.
The inventor finds similar patents on the aspect of plasma freeze-drying in the process of searching patents, for example, the application numbers are as follows: in 201420336899. X's the chinese patent, a novel horizontal plasma refrigeration storage case is disclosed, including box, box door, quick-witted case, control system, three purpose-built fan, the box door articulates at the box top, and the machine case sets up in the box outside, control system arranges machine roof portion in, purpose-built fan includes flabellum, bearing cap, motor, it has the through-hole that three radius equals to open on the box rear side, the through-hole radius equals with the bearing radius, partly pass the through-hole of bearing and stretch into in the box, partly arrange in outside the box, arrange the outer bearing of box in and be connected with the motor, arrange bearing end sealing connection in the box in and have the bearing cap, the flabellum is arranged in on the bearing cap. The invention has simple structure, simple and convenient process, good air convection effect, uniform temperature in the box, fast temperature reduction, and capability of reducing the temperature to-50 ℃ in the box within 30 minutes in no-load, and the lowest temperature can reach-86 ℃, thereby ensuring the biological activity of the blood plasma to the maximum extent.
For example, application numbers are: 201210076601.1 discloses a plasma instant freezer, which is characterized in that the freezing plate is divided into a fixed freezing plate and a movable freezing plate, the fixed freezing plate is connected with the inner wall of the box cover, the movable freezing plate is arranged under the fixed freezing plate through a lifting mechanism, the refrigerator is connected with the freezing plate through a cold guide pipe, the movable freezing plate is provided with a plasma tray, two sides of the movable freezing plate are respectively provided with a fixed guide rail with a convex middle, the plasma tray corresponding to the fixed guide rail is provided with a movable guide rail with the same shape as the fixed guide rail, a platform at the front end of the fixed guide rail and the rear end of the movable guide rail is provided with a guide supporting wheel, a displacement sensor is arranged above the box cover through a bracket, the deformation of the box body sheet metal is detected by the position sensor to replace a pressure sensor, the displacement sensor and an operation key are respectively connected with a controller through data lines, a control circuit, the plasma quick-freezing device has the advantages of convenience in assembly, reduction in production cost, simplicity in operation, stability in movement, high freezing speed, large quick-freezing quantity, high automation degree, good plasma quick-freezing effect and the like.
Based on the aforesaid, traditional plasma refrigerating plant can only carry out the frozen storage to plasma, and storage mode is single, when saving plasma, and the quality of its storage intracavity portion air can't obtain guaranteeing, influences the effect that inside plasma was saved, uses inconveniently, the function singleness.
In view of the above, the present inventors have studied and improved the conventional structure and drawbacks, and have provided a freeze-dried plasma device.
Disclosure of Invention
In order to solve the above technical problems, the present invention provides a freeze-drying device for plasma, which solves the above problems.
The purpose and the efficacy of the plasma freeze-drying device are achieved by the following specific technical means:
a freeze-drying plasma device comprises an inner barrel, an outer barrel, a spiral heating pipe, a threaded through hole, a blood storage column, a limiting cover, a screwed threaded column, a blood bag bin, a bin door, a magnet strip, an air vent, an air inlet channel, a sealing door, an activated carbon filter screen, a nanofiber filter screen, a stainless steel filter screen, a fan, a Y-shaped channel, an isolation valve, a condensation chamber, a refrigeration compressor, a vacuum pump and a temperature controller; the outer barrel is sleeved outside the inner barrel through the top end of the inner barrel, the top end surface of the inner barrel is annularly provided with a threaded through hole, the blood storage column is screwed into the threaded through hole through a screwed threaded column at the upper end of the blood storage column, so that a blood bag bin at the lower end of the blood storage column is placed in the inner barrel, the air inlet channel passes through the outer barrel and is communicated with the inner barrel, the outer end surface of the air inlet channel is hinged with a sealing door, an active carbon filter screen, a nanofiber filter screen and a stainless steel filter screen are sequentially embedded in the inner cavity of the air inlet channel, a fan is fixed on the rear end side of the stainless steel filter screen, the Y-shaped channel also passes through the outer barrel and is communicated with the other side of the inner barrel, the outer end of the Y-shaped channel is respectively connected with a condensation chamber through an isolation valve, the outer end side of the condensation chamber is connected with a, the bottom of the inner side of the outer barrel is provided with a spiral heating pipe, and the spiral heating pipe is electrically connected with a temperature controller fixed on the outer surface of the outer barrel through a conducting wire.
Furthermore, the diameter of the bottom end of the outer barrel is larger than that of the upper end of the outer barrel, a water injection hole and a water drainage hole are respectively formed in the upper end side and the outer side of the bottom end of the outer barrel, and plugs are screwed in the water injection hole and the water drainage hole.
Further, the blood storage column comprises a limiting cover, a screwed thread column, a blood bag bin and a bin gate, and the blood bag bin and the bin gate are connected in an adsorption and clamping mode through magnet strips.
Furthermore, a sealing ring is sleeved at the contact end of the limiting cover and the screwed threaded column.
Furthermore, the blood bag bin and the bin door are both provided with air holes.
Further, a screwing cap is arranged at the top of the blood storage column.
Further, sealing structures are arranged between the outer barrel and the air inlet channel and between the outer barrel and the Y-shaped channel.
Further, a control panel is further installed on the outer side of the outer barrel, and the control panel is connected with the fan, the refrigeration compressor and the vacuum pump through leads respectively.
Compared with the prior art, the invention has the following beneficial effects:
the plasma bag can be placed into the inner barrel through the blood storage column, the water in the outer barrel can be heated by the spiral heating pipe, so that the inner barrel is kept at a relatively constant temperature, the temperature is better controlled compared with the method of directly adopting a heating plate, and meanwhile, the inner barrel can be vacuumized through the vacuum pump, so that the storage time of the plasma is prolonged.
The setting of air inlet channel and inboard filter screen, when in screwing in the screw through-hole with blood storage column, open air inlet channel's sealing door, through the fan with outside air suction to interior bucket, the inside air of bucket filters under the effect of active carbon filter screen and nanofiber filter screen in flowing into to utilize fan and vacuum pump to change the air in the bucket, improve the quality of the air of bucket.
The setting of isolation valve can separate condensation chamber and interior bucket, also can be with condensation chamber and interior bucket intercommunication, utilizes the compressor to freeze the plasma in the bucket, and the preservation mode is various.
Drawings
Fig. 1 is a schematic top view of the present invention.
FIG. 2 is a schematic view showing the structure of the inner barrel of the present invention after the blood storing column is unscrewed.
FIG. 3 is a schematic side view of the inner tub, the outer tub and the air intake channel of the present invention.
FIG. 4 is a schematic view of the structure of the blood storing column of the present invention.
FIG. 5 is a schematic view of the internal structure of the air intake duct of the present invention.
Fig. 6 is a schematic view of the structure of the spiral heating pipe of the present invention.
Fig. 7 is a schematic view of the structure of the water injection hole and the water discharge hole of the present invention.
Fig. 8 is a system control block diagram of the present invention.
In the figure: 1-inner barrel, 101-outer barrel, 1011-spiral heating pipe, 102-threaded through hole, 2-blood storage column, 201-limit cover, 202-screwed threaded column, 203-blood bag bin, 204-bin gate, 205-magnet strip, 206-air vent, 3-air inlet channel, 301-sealing gate, 302-active carbon filter screen, 303-nanofiber filter screen, 304-stainless steel filter screen, 305-fan, 4-Y channel, 401-isolation valve, 5-condensation chamber, 501-refrigeration compressor, 6-vacuum pump and 7-temperature controller.
Detailed Description
The invention is further described below with reference to the accompanying drawings:
example (b):
as shown in figures 1 to 8:
the invention provides a freeze-drying plasma device, which comprises an inner barrel 1, an outer barrel 101, a spiral heating pipe 1011, a threaded through hole 102, a blood storage column 2, a limit cover 201, a screwed threaded column 202, a blood bag bin 203, a bin gate 204, a magnet strip 205, an air vent 206, an air inlet channel 3, a sealing door 301, an active carbon filter screen 302, a nanofiber filter screen 303, a stainless steel filter screen 304, a fan 305, a Y-shaped channel 4, an isolation valve 401, a condensation chamber 5, a refrigeration compressor 501, a vacuum pump 6 and a temperature controller 7; the outer barrel 101 is sleeved outside the inner barrel 1 through the top end of the inner barrel 1, the top end surface of the inner barrel 1 is annularly provided with a threaded through hole 102, the blood storage column 2 is screwed into the threaded through hole 102 through a screwed threaded column 202 at the upper end of the blood storage column 2, so that a blood bag bin 203 at the lower end of the blood storage column 2 is placed in the inner barrel 1;
the air inlet channel 3 penetrates through the outer barrel 101 to be communicated with the inner barrel 1, a sealing door 301 is hinged to the outer end face of the air inlet channel 3, an active carbon filter screen 302, a nanofiber filter screen 303 and a stainless steel filter screen 304 are sequentially embedded in an inner cavity of the air inlet channel 3, a fan 305 is fixed to the rear end side of the stainless steel filter screen 304, the Y-shaped channel 4 also penetrates through the outer barrel 101 to be communicated with the other side of the inner barrel 1, the outer end of the Y-shaped channel 4 is connected with the condensation chamber 5 through an isolation valve 401, the outer end side of the condensation chamber 5 is connected with a refrigeration compressor 501 through a pipeline, the vacuum pump 6 is connected to the Y-shaped channel 4 in front of the isolation valve 401 through a pipeline and a control valve, a spiral heating pipe 1011 is arranged at the bottom of the inner side of the outer barrel 101, and the spiral.
The diameter of the bottom end of the outer barrel 101 is larger than the diameter of the upper end of the outer barrel 101, a water injection hole and a water drainage hole are respectively formed in the upper end side and the outer side of the bottom end of the outer barrel 101, plugs are screwed in the water injection hole and the water drainage hole, and water in the outer barrel 101 can be replaced through the water injection hole and the water drainage hole.
The blood storage column 2 comprises a limiting cover 201, a screwed threaded column 202, a blood bag bin 203 and a bin gate 204, and the blood bag bin 203 and the bin gate 204 are connected in an adsorption and clamping mode through a magnet strip 205.
Wherein, the contact end cover of the limit cap 201 and the screw thread column 202 is equipped with a sealing ring, when the blood storage column 2 is screwed into the screw thread through hole 102, the sealing ring at the lower end of the limit cap 201 can be used for sealing, thereby preventing the vacuum in the inner barrel 1 from being damaged or reducing the internal freezing effect.
Wherein, the blood bag bin 203 and the bin gate 204 are both provided with air holes 206, and the blood bag bin 203 is communicated with the inner barrel 1 through the air holes 206.
Wherein, the top of blood storage column 2 is provided with twists the cap, conveniently to the installation and the dismantlement of blood storage column 2.
Sealing structures are arranged between the outer barrel 101 and the air inlet channel 3 and between the outer barrel 101 and the Y-shaped channel 4, so that water inside the outer barrel 101 is prevented from leaking.
The outer side of the outer tub 101 is further provided with a control panel, the control panel is connected with the fan 305, the refrigeration compressor 501 and the vacuum pump 6 through wires respectively, and the fan 305, the refrigeration compressor 501 and the vacuum pump 6 can be controlled through the control panel.
The specific use mode and function of the embodiment are as follows:
in the invention, the device is connected with an external power supply, then the blood storage column 2 is screwed into the threaded through hole 102 through the screwed threaded column 202, the sealing effect between the blood storage column 2 and the inner barrel 1 is improved by using the sealing ring at the bottom of the limiting cover 201, the sealing door 301 of the air inlet channel 3 is opened, external air is pumped into the inner barrel 1 through the fan 305, the air flowing into the inner barrel 1 is filtered under the action of the active carbon filter screen 302 and the nano fiber filter screen 303, so that the air in the inner barrel 1 is replaced by using the fan 305 and the vacuum pump 6, the quality of the air in the inner barrel 1 is improved, the condensation chamber 5 is separated from the inner barrel 1, the water in the outer barrel 101 is heated by using the spiral heating pipe 1011, the inner barrel 1 is kept in a relatively constant temperature, meanwhile, the inner barrel 1 can be vacuumized by using the vacuum pump 6, the storage time of plasma is prolonged, the condensation chamber 5 may be communicated with the inner barrel 1, and the plasma in the inner barrel 1 may be frozen and preserved by the refrigeration compressor 501.
The technical solutions of the present invention or similar technical solutions designed by those skilled in the art based on the teachings of the technical solutions of the present invention are all within the scope of the present invention to achieve the above technical effects.

Claims (6)

1. A freeze-drying plasma device comprises an inner barrel (1), an outer barrel (101), a spiral heating pipe (1011), a threaded through hole (102), a blood storage column (2), a limiting cover (201), a screwed threaded column (202), a blood bag bin (203), a bin door (204), a magnet strip (205), an air vent (206), an air inlet channel (3), a sealing door (301), an active carbon filter screen (302), a nanofiber filter screen (303), a stainless steel filter screen (304), a fan (305), a Y-shaped channel (4), an isolation valve (401), a condensation chamber (5), a refrigeration compressor (501), a vacuum pump (6) and a temperature controller (7);
the method is characterized in that: the outer barrel (101) is sleeved outside the inner barrel (1) through the top end of the inner barrel (1), and the top end surface of the inner barrel (1) is annularly provided with a threaded through hole (102);
the blood storage column (2) is screwed into the threaded through hole (102) through the screwed threaded column (202) at the upper end of the blood storage column so that the blood bag bin (203) at the lower end of the blood storage column (2) is placed into the inner barrel (1);
the air inlet channel (3) penetrates through the outer barrel (101) to be communicated with the inner barrel (1), and a sealing door (301) is hinged to the outer end face of the air inlet channel (3);
an active carbon filter screen (302), a nanofiber filter screen (303) and a stainless steel filter screen (304) are sequentially embedded in the inner cavity of the air inlet channel (3), and a fan (305) is fixed on the rear end side of the stainless steel filter screen (304);
the Y-shaped channel (4) also penetrates through the outer barrel (101) to be communicated with the other side of the inner barrel (1), the outer end of the Y-shaped channel (4) is connected with a condensing chamber (5) through an isolation valve (401), and the outer end side of the condensing chamber (5) is connected with a refrigeration compressor (501) through a pipeline;
the vacuum pump (6) is connected to the Y-shaped channel (4) on the front side of the isolation valve (401) through a pipeline and a control valve;
the bottom of the inner side of the outer barrel (101) is provided with a spiral heating pipe (1011), and the spiral heating pipe (1011) is electrically connected with a temperature controller (7) fixed on the outer surface of the outer barrel (101) through a conducting wire;
the blood storage column (2) comprises a limiting cover (201), a screwed threaded column (202), a blood bag bin (203) and a bin door (204), and the blood bag bin (203) and the bin door (204) are connected in an adsorption and clamping manner through a magnet strip (205);
the blood bag bin (203) and the bin gate (204) are both provided with air holes (206).
2. The device for freeze-drying plasma according to claim 1, wherein: the diameter of the bottom end of the outer barrel (101) is larger than that of the upper end of the outer barrel (101), a water injection hole and a water drainage hole are respectively formed in the upper end side and the outer side of the bottom end of the outer barrel (101), and plugs are screwed in the water injection hole and the water drainage hole.
3. The device for freeze-drying plasma according to claim 1, wherein: and a sealing ring is sleeved at the contact end of the limiting cover (201) and the screwed threaded column (202).
4. The device for freeze-drying plasma according to claim 1, wherein: the top of the blood storage column (2) is provided with a screwing cap.
5. The device for freeze-drying plasma according to claim 1, wherein: and sealing structures are arranged among the outer barrel (101), the air inlet channel (3) and the Y-shaped channel (4).
6. The device for freeze-drying plasma according to claim 1, wherein: the outer side of the outer barrel (101) is also provided with a control panel, and the control panel is respectively connected with the fan (305), the refrigeration compressor (501) and the vacuum pump (6) through leads.
CN201711489961.3A 2017-12-30 2017-12-30 Plasma freeze-drying device Active CN108332506B8 (en)

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CN108332506B true CN108332506B (en) 2020-02-18
CN108332506B8 CN108332506B8 (en) 2020-05-05

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202420109U (en) * 2011-12-12 2012-09-05 天津市天商冰源科技发展有限公司 Vacuum quick-frozen device of plasma quick-frozen machine
CN203857704U (en) * 2014-06-04 2014-10-01 大连双瑞科技有限公司 Refrigerating system and vacuum freezing drying machine using same
CN104949473A (en) * 2015-07-03 2015-09-30 北京海合天科技开发有限公司 Vacuum freeze drying method and vacuum freeze dryer
CN105202847A (en) * 2015-09-07 2015-12-30 中科美菱低温科技有限责任公司 Portable blood refrigerator realizing uniform refrigeration
CN105300006A (en) * 2015-10-15 2016-02-03 江苏智胜医疗器械科技有限公司 Medical blood storage system
WO2016148254A1 (en) * 2015-03-18 2016-09-22 大陽日酸株式会社 Cryopreservation device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202420109U (en) * 2011-12-12 2012-09-05 天津市天商冰源科技发展有限公司 Vacuum quick-frozen device of plasma quick-frozen machine
CN203857704U (en) * 2014-06-04 2014-10-01 大连双瑞科技有限公司 Refrigerating system and vacuum freezing drying machine using same
WO2016148254A1 (en) * 2015-03-18 2016-09-22 大陽日酸株式会社 Cryopreservation device
CN104949473A (en) * 2015-07-03 2015-09-30 北京海合天科技开发有限公司 Vacuum freeze drying method and vacuum freeze dryer
CN105202847A (en) * 2015-09-07 2015-12-30 中科美菱低温科技有限责任公司 Portable blood refrigerator realizing uniform refrigeration
CN105300006A (en) * 2015-10-15 2016-02-03 江苏智胜医疗器械科技有限公司 Medical blood storage system

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CN108332506A (en) 2018-07-27

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