CN108323184A - 验证生物标志物测量 - Google Patents

验证生物标志物测量 Download PDF

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Publication number
CN108323184A
CN108323184A CN201680043261.9A CN201680043261A CN108323184A CN 108323184 A CN108323184 A CN 108323184A CN 201680043261 A CN201680043261 A CN 201680043261A CN 108323184 A CN108323184 A CN 108323184A
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CN
China
Prior art keywords
value
control value
biomarker
biomarker values
gene expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680043261.9A
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English (en)
Chinese (zh)
Inventor
里奥·查尔斯·麦克休
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Immunexpress Pty Ltd
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Immunexpress Pty Ltd
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Filing date
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Priority claimed from AU2015901982A external-priority patent/AU2015901982A0/en
Application filed by Immunexpress Pty Ltd filed Critical Immunexpress Pty Ltd
Publication of CN108323184A publication Critical patent/CN108323184A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Public Health (AREA)
  • Bioethics (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201680043261.9A 2015-05-28 2016-05-20 验证生物标志物测量 Pending CN108323184A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015901982 2015-05-28
AU2015901982A AU2015901982A0 (en) 2015-05-28 Validating biomarker measurement
PCT/AU2016/050388 WO2016187655A1 (en) 2015-05-28 2016-05-20 Validating biomarker measurement

Publications (1)

Publication Number Publication Date
CN108323184A true CN108323184A (zh) 2018-07-24

Family

ID=57392259

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680043261.9A Pending CN108323184A (zh) 2015-05-28 2016-05-20 验证生物标志物测量

Country Status (9)

Country Link
US (2) US10719579B2 (https=)
EP (1) EP3304093B1 (https=)
JP (1) JP2018525703A (https=)
CN (1) CN108323184A (https=)
AU (1) AU2016267392B2 (https=)
CA (1) CA2986787A1 (https=)
DK (1) DK3304093T3 (https=)
HK (1) HK1249182A1 (https=)
WO (1) WO2016187655A1 (https=)

Cited By (6)

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CN109374904A (zh) * 2018-10-29 2019-02-22 浙江医院 一种蛋白质类脓毒症标志物及其在严重脓毒症早期预警的应用及其筛选方法
CN110408692A (zh) * 2018-09-14 2019-11-05 北京泱深生物信息技术有限公司 血液中的分子作为诊断脓毒症的标志物
CN113488107A (zh) * 2021-07-07 2021-10-08 广州华银健康医疗集团股份有限公司 筛选免疫组库测序生物标志物的方法、设备和存储介质
CN114628024A (zh) * 2022-02-24 2022-06-14 重庆市急救医疗中心(重庆市第四人民医院、重庆市急救医学研究所) 一种生物标志物组在制备用于辅助筛查脓毒症的产品中的用途和辅助筛查方法及其系统
CN114829882A (zh) * 2019-11-05 2022-07-29 阿比尔技术公司 植物产品中感染的预测
US12462902B2 (en) 2020-02-12 2025-11-04 Peptilogics, Inc. Artificial intelligence engine architecture for generating candidate drugs

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AU2016267392B2 (en) * 2015-05-28 2021-12-09 Immunexpress Pty Ltd Validating biomarker measurement
EP3879535B1 (en) * 2017-06-13 2024-12-11 BostonGene Corporation Systems and methods for identifying cancer treatments from normalized biomarker scores
US11430543B2 (en) * 2017-08-04 2022-08-30 Billiontoone, Inc. Sequencing output determination and analysis with target-associated molecules in quantification associated with biological targets
KR102633621B1 (ko) 2017-09-01 2024-02-05 벤 바이오사이언시스 코포레이션 진단 및 치료 모니터링용 바이오마커로서의 당펩티드의 식별 및 용도
WO2019183052A1 (en) * 2018-03-19 2019-09-26 Sri International Methods and systems for biomarker analysis
WO2021202620A1 (en) * 2020-03-31 2021-10-07 The Board Of Trustees Of The Leland Stanford Junior University Metabolomics approach combined with machine learning to recognize a medical condition
EP4195212A1 (en) * 2021-12-08 2023-06-14 A3P Biomedical AB (publ) Certainty-based medical conclusion model adaptation
WO2025094604A1 (ja) * 2023-10-31 2025-05-08 アークレイ株式会社 検知方法、検知装置、検知システム、検知プログラム、及び記録媒体

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US20040180365A1 (en) * 2002-12-13 2004-09-16 Affymetrix, Inc. Methods and computer software products for gene expression data quality analysis
US20090203534A1 (en) * 2005-10-21 2009-08-13 Hamid Hossain Expression profiles for predicting septic conditions
WO2012068642A1 (en) * 2010-11-26 2012-05-31 Immunexpress Pty Ltd Diagnostic and/or screening agents and uses therefor
CN103492590A (zh) * 2011-02-22 2014-01-01 卡里斯生命科学卢森堡控股有限责任公司 循环生物标志物
CN103620019A (zh) * 2011-04-18 2014-03-05 迪阿米尔有限责任公司 基于miRNA的通用筛选试验(UST)

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US7622260B2 (en) * 2001-09-05 2009-11-24 The Brigham And Women's Hospital, Inc. Diagnostic and prognostic tests
CA2577741A1 (en) 2004-08-18 2006-03-02 Abbott Molecular, Inc. Determining data quality and/or segmental aneusomy using a computer system
CA2605143A1 (en) * 2005-04-15 2006-10-26 Becton, Dickinson And Company Diagnosis of sepsis
US20070255113A1 (en) * 2006-05-01 2007-11-01 Grimes F R Methods and apparatus for identifying disease status using biomarkers
US20080213768A1 (en) * 2006-08-17 2008-09-04 Zhauhui Cai Identification and use of biomarkers for non-invasive and early detection of liver injury
DE102007010252B4 (de) 2007-03-02 2013-07-04 Sirs-Lab Gmbh Kontrollgene zur Normalisierung von Genexpressionsanalysedaten
CA2604317C (en) * 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
JP4666237B2 (ja) 2008-07-09 2011-04-06 ソニー株式会社 遺伝子検定方法、遺伝子検定プログラム及び遺伝子検定装置
US9217747B2 (en) * 2009-10-29 2015-12-22 Health Diagnostic Laboratory, Inc. Protein and lipid biomarkers providing consistent improvement to the prediction of type 2 diabetes
US20120035860A1 (en) 2010-04-29 2012-02-09 Akmaev Viatcheslav R GC Wave Correction for Array-Based Comparative Genomic Hybridization
WO2013152989A2 (en) * 2012-04-10 2013-10-17 Eth Zurich Biomarker assay and uses thereof for diagnosis, therapy selection, and prognosis of cancer
CA2877975C (en) * 2012-04-13 2021-09-21 Oasis Diagnostics Corporation Specific salivary biomarkers for risk detection, early diagnosis, prognosis and monitoring of alzheimer's and parkinson's diseases
US10190169B2 (en) 2013-06-20 2019-01-29 Immunexpress Pty Ltd Biomarker identification
US11047010B2 (en) 2014-02-06 2021-06-29 Immunexpress Pty Ltd Biomarker signature method, and apparatus and kits thereof
AU2016267392B2 (en) * 2015-05-28 2021-12-09 Immunexpress Pty Ltd Validating biomarker measurement

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
US20040180365A1 (en) * 2002-12-13 2004-09-16 Affymetrix, Inc. Methods and computer software products for gene expression data quality analysis
US20090203534A1 (en) * 2005-10-21 2009-08-13 Hamid Hossain Expression profiles for predicting septic conditions
WO2012068642A1 (en) * 2010-11-26 2012-05-31 Immunexpress Pty Ltd Diagnostic and/or screening agents and uses therefor
CN103492590A (zh) * 2011-02-22 2014-01-01 卡里斯生命科学卢森堡控股有限责任公司 循环生物标志物
CN103620019A (zh) * 2011-04-18 2014-03-05 迪阿米尔有限责任公司 基于miRNA的通用筛选试验(UST)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110408692A (zh) * 2018-09-14 2019-11-05 北京泱深生物信息技术有限公司 血液中的分子作为诊断脓毒症的标志物
CN109374904A (zh) * 2018-10-29 2019-02-22 浙江医院 一种蛋白质类脓毒症标志物及其在严重脓毒症早期预警的应用及其筛选方法
CN114829882A (zh) * 2019-11-05 2022-07-29 阿比尔技术公司 植物产品中感染的预测
CN114829882B (zh) * 2019-11-05 2023-02-28 阿比尔技术公司 植物产品中感染的预测
US12380965B2 (en) 2019-11-05 2025-08-05 Apeel Technology, Inc. Prediction of infection in plant products
US12462902B2 (en) 2020-02-12 2025-11-04 Peptilogics, Inc. Artificial intelligence engine architecture for generating candidate drugs
CN113488107A (zh) * 2021-07-07 2021-10-08 广州华银健康医疗集团股份有限公司 筛选免疫组库测序生物标志物的方法、设备和存储介质
CN113488107B (zh) * 2021-07-07 2022-07-19 广州华银康医疗集团股份有限公司 筛选免疫组库测序生物标志物的方法、设备和存储介质
CN114628024A (zh) * 2022-02-24 2022-06-14 重庆市急救医疗中心(重庆市第四人民医院、重庆市急救医学研究所) 一种生物标志物组在制备用于辅助筛查脓毒症的产品中的用途和辅助筛查方法及其系统

Also Published As

Publication number Publication date
CA2986787A1 (en) 2016-12-01
JP2018525703A (ja) 2018-09-06
HK1249182A1 (zh) 2018-10-26
US20180107783A1 (en) 2018-04-19
AU2016267392B2 (en) 2021-12-09
US10719579B2 (en) 2020-07-21
US20160350477A1 (en) 2016-12-01
AU2016267392A1 (en) 2017-12-07
WO2016187655A1 (en) 2016-12-01
EP3304093A4 (en) 2019-02-06
EP3304093A1 (en) 2018-04-11
DK3304093T3 (da) 2024-02-12
EP3304093B1 (en) 2023-12-27

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Application publication date: 20180724