CN108310145A - A kind of "Huazhi Fugan Granule" and preparation method thereof - Google Patents
A kind of "Huazhi Fugan Granule" and preparation method thereof Download PDFInfo
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- CN108310145A CN108310145A CN201810319932.0A CN201810319932A CN108310145A CN 108310145 A CN108310145 A CN 108310145A CN 201810319932 A CN201810319932 A CN 201810319932A CN 108310145 A CN108310145 A CN 108310145A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of "Huazhi Fugan Granule" and preparation method thereof, which includes following raw material：Oriental wormwood 400g, Radix Salviae Miltiorrhizae 600g, hawthorn 600g, pueraria lobata 600g, rhizoma alismatis 1200g.The present invention has dampness elimination profit turbid, the effect of promoting blood circulation to remove stagnation, can be used for fatty liver, hyperlipemia belong to it is wet it is turbid hold stasis of blood type person under the arm, safely and effectively.
Description
Technical field
The present invention relates to field of traditional Chinese, and in particular to a kind of "Huazhi Fugan Granule" and preparation method thereof.
Background technology
As the improvement of people's living standards, the improvement of dietetic nutrition, addiction delicious food savoury, pure wine delicious wine, overnutrition,
The medical treatment such as figure's obesity and diabetes, chronic hepatitis is improper, or takes damage liver drug for a long time, leads to fat metabolic disturbance, fat
Fat hepatopath is increasing.In recent years epidemiological survey is found, is addicted to drink, is drunk daily more than 100 milliliters, 10 years or more for a long time
Person, fatty liver incidence are 90%；Overweight people's weight is above standard weight fatty liver incidence as 30-40%；It is more than
30% incidences are 50%；Almost there is fatty liver more than 50%.The fat wine-head again of body, fatty liver incidence is more
It is high.In middle and elderly diabetic patient, fatty liver incidence is 50-60%.It can be seen that fatty liver has very high illness rate.Suffer from
After fatty liver, less serious case shows without discomfort, can be found in B-mode ultrasonography.Severe one has hepatalgia more, loses the appetite, and dislikes
The heart is vomitted, epigastric abdominal fullness, and stool is uncomfortable, and the tired body of god is tired, liver enlargement, the diseases such as dysfunction of liver sign.Certain patient's (such as Alcoholics
Fatty liver) it cures and improper develops into hepatic sclerosis.
Based on this stern reality situation, the specific medicament for specifically treating fatty liver there is no both at home and abroad at present.Clinically
Use fall lipid drug, and with liver protection class combination therapies.Such drug mostly be for fatty liver some part or
It is that site morbidity mechanism works, effect is relatively single, and effect is not satisfactory.In addition, lipid-lowering medicine may become blood fat is made more to concentrate
It is metabolized in liver, increases burden of liver, promote accumulation of the lipid in liver instead, and damage liver function, therefore fatty liver
Patient chronically should not blindly take fat-reducing medicament.Therefore, study it is a kind of it is novel, can effectively, safety treatment fatty liver
Drug have very important significance.
Invention content
To solve the above problems, the present invention provides a kind of "Huazhi Fugan Granule"s and preparation method thereof.
To achieve the above object, the technical solution that the present invention takes is：
A kind of "Huazhi Fugan Granule", including following raw material：
Oriental wormwood 400g, Radix Salviae Miltiorrhizae 600g, hawthorn 600g, pueraria lobata 600g, rhizoma alismatis 1200g.
The present invention also provides a kind of preparation methods of "Huazhi Fugan Granule", include the following steps：
S1, each raw material is weighed by above-mentioned formula；
S2, after mixing the Radix Salviae Miltiorrhizae weighed, hawthorn, pueraria lobata, rhizoma alismatis, the ethyl alcohol that the volume fraction of 5 times of amounts is 75% is added
Reflux 2 times, every time 1.5 hours；Merge secondary returning flow liquid, ethyl alcohol is recycled in filtration, spare；The oriental wormwood weighed, mixing is added in the dregs of a decoction
Afterwards, add 8 times amount water decoct 1.5h, filtration, mix with alcohol extract be concentrated under reduced pressure into relative density be 1.25 (60 DEG C) obtain thick medicinal extract；
S3, Icing Sugar and other right amount of auxiliary materials is added in the thick medicinal extract of gained, is made particle, it is dry to get.
The invention has the advantages that：
The present invention has dampness elimination profit turbid, the effect of promoting blood circulation to remove stagnation, can be used for fatty liver, and hyperlipemia belongs to wet and turbid holds stasis of blood type under the arm
Person, safely and effectively.
Specific implementation mode
In order to make objects and advantages of the present invention be more clearly understood, the present invention is carried out with reference to embodiments further
It is described in detail.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to limit this hair
It is bright.
A kind of "Huazhi Fugan Granule", including following raw material：
Oriental wormwood 400g, Radix Salviae Miltiorrhizae 600g, hawthorn 600g, pueraria lobata 600g, rhizoma alismatis 1200g.
The present invention also provides a kind of preparation methods of "Huazhi Fugan Granule", include the following steps：
S1, each raw material is weighed by above-mentioned formula；
S2, after mixing the Radix Salviae Miltiorrhizae weighed, hawthorn, pueraria lobata, rhizoma alismatis, the ethyl alcohol that the volume fraction of 5 times of amounts is 75% is added
Reflux 2 times, every time 1.5 hours；Merge secondary returning flow liquid, ethyl alcohol is recycled in filtration, spare；The oriental wormwood weighed, mixing is added in the dregs of a decoction
Afterwards, add 8 times amount water decoct 1.5h, filtration, mix with alcohol extract be concentrated under reduced pressure into relative density be 1.25 (60 DEG C) obtain thick medicinal extract；
S3, Icing Sugar and other right amount of auxiliary materials is added in the thick medicinal extract of gained, particle is made, it is dry to get this product is dark brown
The particle of color, taste are slightly sour.
Differentiate：(1) this product 10g is taken, is set in separatory funnel, water 40ml is added, is shaken, add diethyl ether 50ml.3 points of shaking extraction
Clock centrifuges, point takes ether solution, adds anhydrous sodium sulfate 1g, shakes, filtration, and the residue 1ml that adds diethyl ether makes dissolving, as examination
Product solution.Tanshinone IIA reference substance separately is taken, adds diethyl ether and solution of every 1ml containing 0.7mg is made, as a contrast product solution.According to thin layer
Chromatography (annex VIB) is tested, and each 10-15ul of above two solution is drawn, and is put respectively on same silica gel g thin-layer plate, with chlorine
It imitates as solvent, is unfolded, take out, dry.In test sample chromatography, on position corresponding with control chromatography, identical red is shown
Spot.
(2) this product 10g is taken, it is finely ground, add ethyl alcohol 50ml, be heated to reflux 30 minutes, filter, filtrate is evaporated, and residue adds 0.3%
After sodium hydroxide solution 20ml dissolvings in dislocation separatory funnel, after adjusting pH value to 5-6 with dilute hydrochloric acid, shaken with ethyl acetate 20ml
Extraction is shaken, divides and takes ethyl acetate layer, be dehydrated with anhydrous sodium sulfate, is filtered, filtrate is evaporated, and residue adds ethyl acetate 2ml to make dissolving.
As test solution.Separately Puerarin reference substance is taken to add absolute ethyl alcohol that solution of every 1ml containing 1ml is made, as a contrast product solution.
It is tested according to thin-layered chromatography (annex IVB), draws test solution 10ul, 2 μ l of reference substance solution are put respectively in same with carboxylic first
Base sodium cellulosate is with chloroform-methanol (4: 1) for solvent, to be unfolded on the silica gel g thin-layer plate of binder, take out, dry, set
It is smoked 15 minutes in ammonia steam, sets and inspected under ultraviolet lamp (365nm).In test sample chromatography, in position corresponding with reference substance chromatography
It sets, shows identical blue-fluorescence spot.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the principle of the present invention, it can also make several improvements and retouch, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (2)
1. a kind of "Huazhi Fugan Granule", which is characterized in that including following raw material：
Oriental wormwood 400g, Radix Salviae Miltiorrhizae 600g, hawthorn 600g, pueraria lobata 600g, rhizoma alismatis 1200g.
2. a kind of preparation method of "Huazhi Fugan Granule", which is characterized in that include the following steps：
S1, formula as described in claim 1 weigh each raw material；
S2, after mixing the Radix Salviae Miltiorrhizae weighed, hawthorn, pueraria lobata, rhizoma alismatis, the alcohol reflux 2 that the volume fraction of 5 times of amounts is 75% is added
It is secondary, 1.5 hours every time；Merge secondary returning flow liquid, ethyl alcohol is recycled in filtration, spare；The oriental wormwood weighed is added in the dregs of a decoction, after mixing, adds
8 times amount water decoct 1.5h, filtration, mix with alcohol extract be concentrated under reduced pressure into relative density be 1.25 (60 DEG C) obtain thick medicinal extract；
S3, Icing Sugar and other right amount of auxiliary materials is added in the thick medicinal extract of gained, is made particle, it is dry to get.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810319932.0A CN108310145A (en) | 2018-03-29 | 2018-03-29 | A kind of "Huazhi Fugan Granule" and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810319932.0A CN108310145A (en) | 2018-03-29 | 2018-03-29 | A kind of "Huazhi Fugan Granule" and preparation method thereof |
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| CN108310145A true CN108310145A (en) | 2018-07-24 |
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| CN201810319932.0A Pending CN108310145A (en) | 2018-03-29 | 2018-03-29 | A kind of "Huazhi Fugan Granule" and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113425788A (en) * | 2021-07-06 | 2021-09-24 | 北京中医药大学 | Traditional Chinese medicine composition for treating liver diseases and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537582A (en) * | 2003-04-15 | 2004-10-20 | 毛友昌 | Shenqi Gankang granule contg. ginseng and ast4ragalus mongholicus for treating liver disease, and its prepn. method |
-
2018
- 2018-03-29 CN CN201810319932.0A patent/CN108310145A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537582A (en) * | 2003-04-15 | 2004-10-20 | 毛友昌 | Shenqi Gankang granule contg. ginseng and ast4ragalus mongholicus for treating liver disease, and its prepn. method |
Non-Patent Citations (7)
| Title |
|---|
| 何秀斌等: "化脂复肝汤治疗脂肪肝27例", 《中国医药导报》 * |
| 刘建: "《给教师的健康枕边书》", 30 September 2015, 山东科学技术出版社 * |
| 刘晓彦等: "非酒精性脂肪肝的中医药实验研究进展", 《中医药学刊》 * |
| 姜德民等: "非酒精性脂肪肝的中医药研究进展", 《西部中医药》 * |
| 张欣等: "化脂复肝颗粒治疗脂肪肝124例", 《上海中医药杂志》 * |
| 王婷: "参芪肝康胶囊质量控制方法及药物动力学研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
| 薛敬东等: "化脂复肝颗粒治疗脂肪肝作用机理的研究", 《中国中医基础医学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113425788A (en) * | 2021-07-06 | 2021-09-24 | 北京中医药大学 | Traditional Chinese medicine composition for treating liver diseases and preparation method and application thereof |
| CN113425788B (en) * | 2021-07-06 | 2022-05-10 | 北京中医药大学 | Traditional Chinese medicine composition for treating liver diseases and preparation method and application thereof |
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Application publication date: 20180724 |