CN108294995A - A kind of preparation method of acne eliminating cream - Google Patents
A kind of preparation method of acne eliminating cream Download PDFInfo
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Abstract
The invention discloses a kind of preparation methods of acne eliminating cream, belong to cosmetic field.The present invention is using the licorice slag after extracting glycyrrhizic acid as raw material, isolated isoliquiritigenin and glabridin, it can effectively inhibit the activity of tyrosinase and the generation of melanocyte, to achieve the purpose that anti-acne and go acne print, it is mixed simultaneously with tea oil, since tea oil is a kind of natural antibacterial agent, antibacterial activity is mainly 4 alcohol of mushroom alkene, it can effectively prevent small pox and continue to occur, and it controls the position suppurated and deteriorates again, it is additionally added that chitin is etherified to prepare water soluble chitin derivative so as to achieve the purpose that water lock, control the water and oil balance of skin, reduce the generation rate of small pox, thickener is added, resveratrol, there is fabulous compatibility to skin, it is nonirritant.The common product for resolving poxes effect that the present invention solves at present on the market is single, can only anti-inflammatory or simple sterilization, cannot thoroughly solve the problems, such as whelk.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of preparation method of acne eliminating cream.
Background technology
Acne eliminating cream, one of skin type cosmetic product.Whelk is a kind of common skin disease of young people, is mainly in green few
Year, it is one of the principal disease for influencing people's beauty and quality of life, the acne eliminating cream researched and developed in contrast is to belong to controlling for external application
Treat product.Small pox is caused by two reasons mostly, and one is because skin belongs to Oily, and sebaceous glands is excessively flourishing,
Sebum secretion is excessively prosperous.If pore is blocked either because other reasons cause oil extraction unsmooth, sebaceous glands continues to secrete,
Sebum just get up in pore by accumulation, and protrusion becomes small pox.Another reason is that hormone in vivo secretion is unbalance, keep skin long
Acne.This reason is relatively common when hebetic.Hormone secretion is unbalance also to cause sebum secretion excessively vigorous indirectly, from
And it is further exacerbated by the situation of small pox.Whelk is that have to improve with Serum Testosterone Levels, and smegma is vigorous, hair follicle hair is all
Change, bacillus and bacterium infection etc. are related.
For the cause of disease of whelk, the product for resolving poxes developed is gathered around have a large amount in variety on the market, but safe and efficient
Product it is seldom.Common product for resolving poxes effect on the market is single, can only anti-inflammatory or simple sterilization, cannot thoroughly solve the youth
The problem of acne.
Invention content
The technical problems to be solved by the invention：It is single for common product for resolving poxes effect at present on the market, it can only disappear
Scorching or simple sterilization, cannot thoroughly solve the problems, such as whelk, provide a kind of preparation method of acne eliminating cream.
In order to solve the above technical problems, the present invention is using technical solution as described below：
A kind of preparation method of acne eliminating cream, the preparation method include the following steps：
（1）Licorice slag is dried at 50 ~ 60 DEG C of temperature, obtains dried object, in mass ratio 1：5, by dried object, volume point
Number is mixed for 95% ethyl alcohol, and the ultrasonic extraction at 40 ~ 60 DEG C of temperature obtains extracting solution, extracting solution is carried out recycling ethyl alcohol,
It is concentrated under reduced pressure, obtains concentrate；
（2）It counts in parts by weight, 10 ~ 15 parts of water, 5 ~ 7 portions of mixed liquors, 3 ~ 5 parts of methanol, 1 ~ 3 part of concentrate is taken, by concentrate, water
It is mixed, is stirred, mixed liquor is added and is extracted, obtains extract liquor, extract liquor is dried, methanol is added, is uniformly mixed,
Rotary evaporation obtains evaporant, and evaporant is placed at the top of polyamide, and eluent is collected in elution, is concentrated under reduced pressure, and freezing is dry
It is dry, it crushes, obtains crushed material；
（3）In mass ratio 1：2 ~ 4, crushed material, tea oil are mixed, stirred evenly, stirring thing is obtained, counts in parts by weight,
10 ~ 15 parts of soybean lecithins, 5 ~ 7 parts of stirring things, 3 ~ 5 parts of cholesterol, 1 ~ 3 part of Tween 80,1 ~ 3 part of absolute ethyl alcohol are taken, by soybean
Lecithin, cholesterol are mixed, and are stirred evenly, and stirring thing, Tween 80, absolute ethyl alcohol is added, is placed in 40 ~ 45 DEG C of temperature
It is vibrated in water-bath, obtains oscillation liquid, in mass ratio 1：5 ~ 7, oscillation liquid is injected into phosphate buffer, is placed in 40 ~ 45 DEG C of water
Rotary evaporation in vacuo in bath, processing, is then sonicated, as B phases；
（4）In mass ratio 1：7 ~ 9, chitin, sodium hydroxide solution are mixed, the 12 of chitin quality 8 ~ 10% are added
Sodium alkyl sulfate freezes at temperature -20 ~ -15 DEG C, obtains frozen material, in mass ratio 1：5 ~ 8, by frozen material, isopropanol in temperature
It is mixed at 20 ~ 25 DEG C, adjusts pH value to 7, filtering obtains filter residue, filter residue is washed with ethyl alcohol, obtains washings, in mass ratio 1：5：
10, washings, water, acetone are subjected to mixed precipitation, filtering obtains filter residue a, and filter residue a is dried at 50 ~ 60 DEG C of temperature, must be dried
Dry；
（5）In mass ratio 1：3 ~ 5, drying object, water are mixed, are heated to 70 ~ 80 DEG C, homogeneous is kept the temperature, as A phases, by matter
Measure ratio 1：0.8, under agitation, B phases are added into A phases, are heated to 50 ~ 70 DEG C, the thickening of A phases quality 0.7 ~ 0.9% is added
Homogeneous is stirred in agent, is cooled to 40 ~ 45 DEG C, and the resveratrol of A phases quality 0.1 ~ 0.2% is added, vacuumizes, and stirs homogeneous, filtering
Discharging collects paste to get acne eliminating cream.
The step（1）Middle mixed liquor is in mass ratio 1：0.5, petroleum ether, chloroform are uniformly mixed to get mixing
Liquid.
The step（3）Middle phosphate buffer is in mass ratio 6：1：70 ~ 80, by sodium dihydrogen phosphate, disodium hydrogen phosphate,
Water is mixed to get phosphate buffer.
The step（5）Middle thickener is in mass ratio 5：3, tartaric acid, coconut oil diethanol amide are uniformly mixed,
Up to thickener.
Compared with other methods, advantageous effects are the present invention：
（1）The present invention is using the licorice slag after extracting glycyrrhizic acid as raw material, and isolated isoliquiritigenin and glabridin can
Effectively inhibit the activity of tyrosinase and the generation of melanocyte, to achieve the purpose that anti-acne and go acne print, while and tea
Tree oil mixing, since tea oil is a kind of natural antibacterial agent, antibacterial activity is mainly mushroom alkene -4- alcohol, can effectively prevent acne
Acne continues to occur, and controls the position suppurated and deteriorate again, then by the nanosizing of nano liposome of tea plant oil, nanosizing can
The percutaneous abilities for greatly improving drug increase the skin targeting of drug, further decrease dosage, reduce or eliminate tea tree
The toxic side effect of oil, and nano liposomes have very high stability, small-size effect, the skin effect of nano material make its tool
There are good dissolubility and diffusion permeability, to further enhance the performance of active ingredient.
（2）The present invention is additionally added that chitin is etherified to prepare water soluble chitin derivative, is that a kind of macromolecule is water-soluble
Property compound, have carboxyl on their polymer segment, since the repulsive interaction of the negative electrical charge on carboxyl keeps macromolecular chain empty
Between stretch especially big, have strong interaction, and the hydrophily and molecule of carboxyl if even if intermolecular under lower concentration
Chain has larger extensibility, strong to the active force of water, and the amount in conjunction with water is also larger, so as to achieve the purpose that water lock, control
The water and oil balance of skin, reduces the generation rate of small pox, while being additionally added thickener, resveratrol, and wherein thickener is to pass through fruit
Acid is mixed with coconut oil diethanol amide, is had fabulous compatibility to skin, is easily absorbed by the skin, nonirritant, nothing
Allergy, conditioning that is safe to use and having effects that splendid foam enhancing, bactericidal antiphlogistic, and resveratrol can not only be used as anti-corrosion
Agent extends the quality guarantee period of acne eliminating cream, and it also can be used as antioxidant, can slow down aging, and makes the oxidation resistant ability of skin
Enhancing, the addition of the two, to be effectively increased use effect of acne eliminating cream.
Specific implementation mode
Mixed liquor is in mass ratio 1：0.5, petroleum ether, chloroform are uniformly mixed to get mixed liquor.
Phosphate buffer is in mass ratio 6：1：70 ~ 80, sodium dihydrogen phosphate, disodium hydrogen phosphate, water are mixed, i.e.,
Obtain phosphate buffer.
Thickener is in mass ratio 5：3, tartaric acid, coconut oil diethanol amide are uniformly mixed to get thickener.
A kind of preparation method of acne eliminating cream, the preparation method include the following steps：
（1）Licorice slag is dried at 50 ~ 60 DEG C of temperature, obtains dried object, in mass ratio 1：5, by dried object, volume point
Number is mixed for 95% ethyl alcohol, and 1 ~ 2h of ultrasonic extraction at 40 ~ 60 DEG C of temperature obtains extracting solution, extracting solution is carried out recycling second
Alcohol is concentrated under reduced pressure, obtains concentrate；
（2）It counts in parts by weight, 10 ~ 15 parts of water, 5 ~ 7 portions of mixed liquors, 3 ~ 5 parts of methanol, 1 ~ 3 part of concentrate is taken, by concentrate, water
It is mixed, is stirred, mixed liquor is added and is extracted, obtains extract liquor, extract liquor is dried, methanol is added, is uniformly mixed,
Rotary evaporation obtains evaporant, and evaporant is placed at the top of polyamide, and eluent is collected in elution, is concentrated under reduced pressure, and freezing is dry
It is dry, it crushes, obtains crushed material；
（3）In mass ratio 1：2 ~ 4, crushed material, tea oil are mixed, stirred evenly, stirring thing is obtained, counts in parts by weight,
10 ~ 15 parts of soybean lecithins, 5 ~ 7 parts of stirring things, 3 ~ 5 parts of cholesterol, 1 ~ 3 part of Tween 80,1 ~ 3 part of absolute ethyl alcohol are taken, by soybean
Lecithin, cholesterol are mixed, and are stirred evenly, and stirring thing, Tween 80, absolute ethyl alcohol is added, is placed in 40 ~ 45 DEG C of temperature
15 ~ 20min is vibrated in water-bath, obtains oscillation liquid, in mass ratio 1：5 ~ 7, oscillation liquid is injected into phosphate buffer, it is placed in 40 ~
Rotary evaporation in vacuo in 45 DEG C of water-bath handles 15 ~ 20min, is then sonicated 8 ~ 10min, spare as B phases；
（4）In mass ratio 1：7 ~ 9, chitin, sodium hydroxide solution are mixed, the 12 of chitin quality 8 ~ 10% are added
Sodium alkyl sulfate freezes 10 ~ 12h at temperature -20 ~ -15 DEG C, obtains frozen material, in mass ratio 1：5 ~ 8, by frozen material, isopropanol
It is mixed at 20 ~ 25 DEG C of temperature, adjusts pH value to 7, filtering obtains filter residue, filter residue is washed with ethyl alcohol, washings is obtained, by quality
Than 1：5：10, washings, water, acetone are subjected to 1 ~ 2h of mixed precipitation, filtering obtains filter residue a, by filter residue a at 50 ~ 60 DEG C of temperature
Drying, obtains drying object；
（5）In mass ratio 1：3 ~ 5, drying object, water are mixed, are heated to 70 ~ 80 DEG C, 3 ~ 7min of homogeneous, heat preservation 30 ~
50min, as A phases, in mass ratio 1：0.8, under agitation, step is added into A phases（3）Spare B phases, are heated to 50
~ 70 DEG C, the thickener of A phases quality 0.7 ~ 0.9% is added, stirs 5 ~ 15min of homogeneous, is cooled to 40 ~ 45 DEG C, A phase quality is added
0.1 ~ 0.2% resveratrol, vacuumizes, and stirs 5 ~ 15min of homogeneous, and filtering and discharging collects paste to get acne eliminating cream.
Embodiment 1
Mixed liquor is in mass ratio 1：0.5, petroleum ether, chloroform are uniformly mixed to get mixed liquor.
Phosphate buffer is in mass ratio 6：1：70, by sodium dihydrogen phosphate, disodium hydrogen phosphate, water mix to get
Phosphate buffer.
Thickener is in mass ratio 5：3, tartaric acid, coconut oil diethanol amide are uniformly mixed to get thickener.
A kind of preparation method of acne eliminating cream, the preparation method include the following steps：
（1）Licorice slag is dried under temperature 50 C, obtains dried object, in mass ratio 1：5, by dried object, volume fraction
It is mixed for 95% ethyl alcohol, the ultrasonic extraction 1h at 40 DEG C of temperature obtains extracting solution, extracting solution is carried out recycling ethyl alcohol, depressurizes
Concentration, obtains concentrate；
（2）It counts in parts by weight, takes 10 parts of water, 5 portions of mixed liquors, 3 parts of methanol, 1 part of concentrate, concentrate, water are mixed,
Stirring is added mixed liquor and is extracted, obtain extract liquor, extract liquor is dried, methanol is added, is uniformly mixed, rotary evaporation,
Evaporant is obtained, evaporant is placed at the top of polyamide, eluent is collected in elution, is concentrated under reduced pressure, and freeze-drying is crushed, obtained
Crushed material；
（3）In mass ratio 1：2, crushed material, tea oil are mixed, stirred evenly, stirring thing is obtained, counts in parts by weight, take
10 parts of soybean lecithins, 5 parts of stirring things, 3 parts of cholesterol, 1 part of Tween 80,1 part of absolute ethyl alcohol, by soybean lecithin, cholesterol
It is mixed, is stirred evenly, stirring thing, Tween 80, absolute ethyl alcohol is added, is placed in the water-bath of 40 DEG C of temperature and vibrates 15min, obtain
Oscillation liquid, in mass ratio 1：5, oscillation liquid is injected into phosphate buffer, rotary evaporation in vacuo in 40 DEG C of water-bath is placed in, locates
15min is managed, 8min is then sonicated, it is spare as B phases；
（4）In mass ratio 1：7, chitin, sodium hydroxide solution are mixed, the dodecyl sulphur of chitin quality 8% is added
Sour sodium freezes 10h at -20 DEG C of temperature, obtains frozen material, in mass ratio 1：5, frozen material, isopropanol are mixed at 20 DEG C of temperature
It closes, adjusts pH value to 7, filtering obtains filter residue, filter residue is washed with ethyl alcohol, obtains washings, in mass ratio 1：5：10, by washings,
Water, acetone carry out mixed precipitation 1h, and filtering obtains filter residue a, filter residue a is dried under temperature 50 C, obtains drying object；
（5）In mass ratio 1：3, drying object, water are mixed, are heated to 70 DEG C, homogeneous 3min, keeps the temperature 30min, as A phases,
In mass ratio 1：0.8, under agitation, step is added into A phases（3）Spare B phases are heated to 50 DEG C, and A phase quality is added
0.7% thickener stirs homogeneous 5min, is cooled to 40 DEG C, and the resveratrol of A phases quality 0.1% is added, vacuumizes, and stirring is equal
Matter 5min, filtering and discharging collect paste to get acne eliminating cream.
Embodiment 2
Mixed liquor is in mass ratio 1：0.5, petroleum ether, chloroform are uniformly mixed to get mixed liquor.
Phosphate buffer is in mass ratio 6：1：80, by sodium dihydrogen phosphate, disodium hydrogen phosphate, water mix to get
Phosphate buffer.
Thickener is in mass ratio 5：3, tartaric acid, coconut oil diethanol amide are uniformly mixed to get thickener.
A kind of preparation method of acne eliminating cream, the preparation method include the following steps：
（1）Licorice slag is dried under temperature 60 C, obtains dried object, in mass ratio 1：5, by dried object, volume fraction
It is mixed for 95% ethyl alcohol, ultrasonic extraction 2h, obtains extracting solution under temperature 60 C, and extracting solution is carried out recycling ethyl alcohol, decompression
Concentration, obtains concentrate；
（2）It counts in parts by weight, takes 15 parts of water, 7 portions of mixed liquors, 5 parts of methanol, 3 parts of concentrates, concentrate, water are mixed,
Stirring is added mixed liquor and is extracted, obtain extract liquor, extract liquor is dried, methanol is added, is uniformly mixed, rotary evaporation,
Evaporant is obtained, evaporant is placed at the top of polyamide, eluent is collected in elution, is concentrated under reduced pressure, and freeze-drying is crushed, obtained
Crushed material；
（3）In mass ratio 1：4, crushed material, tea oil are mixed, stirred evenly, stirring thing is obtained, counts in parts by weight, take
15 parts of soybean lecithins, 7 parts of stirring things, 5 parts of cholesterol, 3 parts of Tween 80s, 3 parts of absolute ethyl alcohols, by soybean lecithin, cholesterol
It is mixed, is stirred evenly, stirring thing, Tween 80, absolute ethyl alcohol is added, is placed in the water-bath of temperature 45 C and vibrates 20min, obtain
Oscillation liquid, in mass ratio 1：7, oscillation liquid is injected into phosphate buffer, rotary evaporation in vacuo in 45 DEG C of water-bath is placed in, locates
20min is managed, 10min is then sonicated, it is spare as B phases；
（4）In mass ratio 1：9, chitin, sodium hydroxide solution are mixed, the dodecyl of chitin quality 10% is added
Sodium sulphate freezes 12h at 15 DEG C of temperature, obtains frozen material, in mass ratio 1：8, frozen material, isopropanol are mixed at 25 DEG C of temperature
It closes, adjusts pH value to 7, filtering obtains filter residue, filter residue is washed with ethyl alcohol, obtains washings, in mass ratio 1：5：10, by washings,
Water, acetone carry out mixed precipitation 2h, and filtering obtains filter residue a, filter residue a is dried under temperature 60 C, obtains drying object；
（5）In mass ratio 1：5, drying object, water are mixed, are heated to 80 DEG C, homogeneous 7min, keeps the temperature 50min, as A phases,
In mass ratio 1：0.8, under agitation, step is added into A phases（3）Spare B phases are heated to 70 DEG C, and A phase quality is added
0.9% thickener stirs homogeneous 15min, is cooled to 45 DEG C, and the resveratrol of A phases quality 0.2% is added, vacuumizes, and stirring is equal
Matter 15min, filtering and discharging collect paste to get acne eliminating cream.
Embodiment 3
Mixed liquor is in mass ratio 1：0.5, petroleum ether, chloroform are uniformly mixed to get mixed liquor.
Phosphate buffer is in mass ratio 6：1：75, by sodium dihydrogen phosphate, disodium hydrogen phosphate, water mix to get
Phosphate buffer.
Thickener is in mass ratio 5：3, tartaric acid, coconut oil diethanol amide are uniformly mixed to get thickener.
A kind of preparation method of acne eliminating cream, the preparation method include the following steps：
（1）Licorice slag is dried at 55 DEG C of temperature, obtains dried object, in mass ratio 1：5, by dried object, volume fraction
It is mixed for 95% ethyl alcohol, ultrasonic extraction 1.5h, obtains extracting solution under temperature 50 C, and extracting solution is carried out recycling ethyl alcohol, is subtracted
Pressure concentration, obtains concentrate；
（2）It counts in parts by weight, takes 12.5 parts of water, 6 portions of mixed liquors, 4 parts of methanol, 2 parts of concentrates, concentrate, water are mixed
It closes, stirring, mixed liquor is added and is extracted, obtains extract liquor, extract liquor is dried, methanol is added, is uniformly mixed, rotation is steamed
Hair, obtains evaporant, and evaporant is placed at the top of polyamide, and eluent is collected in elution, is concentrated under reduced pressure, freeze-drying, powder
It is broken, obtain crushed material；
（3）In mass ratio 1：3, crushed material, tea oil are mixed, stirred evenly, stirring thing is obtained, counts in parts by weight, take
12.5 parts of soybean lecithins, 6 parts of stirring things, 4 parts of cholesterol, 2 parts of Tween 80s, 2 parts of absolute ethyl alcohols, soybean lecithin, courage is solid
Alcohol is mixed, and is stirred evenly, and stirring thing, Tween 80, absolute ethyl alcohol is added, is placed in the water-bath of 42.5 DEG C of temperature and vibrates
17.5min obtains oscillation liquid, in mass ratio 1：6, oscillation liquid is injected into phosphate buffer, is placed in 42.5 DEG C of water-bath true
Empty rotary evaporation handles 17.5min, is then sonicated 9min, spare as B phases；
（4）In mass ratio 1：8, chitin, sodium hydroxide solution are mixed, the dodecyl sulphur of chitin quality 9% is added
Sour sodium freezes 11h at -17.5 DEG C of temperature, obtains frozen material, in mass ratio 1：6.5, by frozen material, isopropanol in temperature 22.5
It is mixed at DEG C, adjusts pH value to 7, filtering obtains filter residue, filter residue is washed with ethyl alcohol, obtains washings, in mass ratio 1：5：10, it will
Washings, water, acetone carry out mixed precipitation 1.5h, and filtering obtains filter residue a, and filter residue a is dried at 55 DEG C of temperature, obtains drying object；
（5）In mass ratio 1：4, drying object, water are mixed, are heated to 75 DEG C, homogeneous 5min, keeps the temperature 40min, as A phases,
In mass ratio 1：0.8, under agitation, step is added into A phases（3）Spare B phases are heated to 60 DEG C, and A phase quality is added
0.8% thickener stirs homogeneous 10min, is cooled to 42.5 DEG C, and the resveratrol of A phases quality 0.15% is added, vacuumizes, stirs
Homogeneous 10min is mixed, filtering and discharging collects paste to get acne eliminating cream.
Comparative example：The acne eliminating cream of Guangzhou company production
Recruit 18~25 years old between, reference《Clinical dermatology》、《People's Republic of China's traditional Chinese medicine industry standard-Chinese medicine skin
Skin section disease Standardization of diagnosis and curative effect》：With typical clinical symptoms and sign, skin lesion is mainly to involve the being dispersed in property of facial area
Blackhead, inflamed papules, warts, tubercle, tumour, 100 more serious volunteers of face's whelk, are randomly divided into 4
Group, every group of 20 volunteers, for every group of correspondence using a kind of acne eliminating cream prepared by embodiment, 1 group of group as a comparison uses nothing daily
The frost of acne-removal function compares.Volunteer daily sooner or later using once, is used continuously 90 days, counts setting time every group of will of point
The whelk removal rate of hope person.Also, volunteer is used 90 days, then Follow-up observation 100 days, check whether to recur.Tracking system
The results are shown in Table 1 for meter.
Performance of keeping humidity is tested：Embodiment and comparative example is sampled, it is accurately weighed after test specimen is separately dried, the steaming of 2 times of quality is added
Distilled water mixes well, and is placed in drier, measures place for 24 hours respectively, the decrement of moisture after 48h, by formula（1）Calculate moisturizing
Rate：
X=m2/mL×100%
In formula：X is moisturizing rate, %；ML is biodiversity before placing, g；m2For the biodiversity after placement, g；
Specific testing result is as shown in table 2：
Table 2
Anti-aging is tested：Embodiment and the acne eliminating cream that comparative example is prepared are tested using dansyl Cl labelling technique.
100 volunteers for having whelk are randomly selected, embodiment group and contrast groups are randomly divided into.Two tested areas of first choice selection,
In a tested area coating present invention acne eliminating cream, the acne eliminating cream of another tested portion of area coating comparative example.Distinguished with dansyl Cl
Fluorescent staining is carried out to volunteer's skin, i.e., gauze is subtracted into 1cm2Size, fills solution of dansyl chloride, is then flattened on same
Recipient site, overlying glass is red, is fixed with adhesive tape, removes dansyl Cl gauze afterwards for 24 hours, excessive stain is washed with water, after
Daily special messenger detects fluorescence recession situation, continuous observation one month at ultraviolet lamp 300nm.Specific testing result is as shown in table 3：
Table 3
In conclusion the acne eliminating cream of the present invention complies fully with requirement, it is worth promoting and uses.
Claims (4)
1. a kind of preparation method of acne eliminating cream, which is characterized in that the preparation method includes the following steps：
（1）Licorice slag is dried at 50 ~ 60 DEG C of temperature, obtains dried object, in mass ratio 1：5, by dried object, volume point
Number is mixed for 95% ethyl alcohol, and the ultrasonic extraction at 40 ~ 60 DEG C of temperature obtains extracting solution, extracting solution is carried out recycling ethyl alcohol,
It is concentrated under reduced pressure, obtains concentrate；
（2）It counts in parts by weight, 10 ~ 15 parts of water, 5 ~ 7 portions of mixed liquors, 3 ~ 5 parts of methanol, 1 ~ 3 part of concentrate is taken, by concentrate, water
It is mixed, is stirred, mixed liquor is added and is extracted, obtains extract liquor, extract liquor is dried, methanol is added, is uniformly mixed,
Rotary evaporation obtains evaporant, and evaporant is placed at the top of polyamide, and eluent is collected in elution, is concentrated under reduced pressure, and freezing is dry
It is dry, it crushes, obtains crushed material；
（3）In mass ratio 1：2 ~ 4, crushed material, tea oil are mixed, stirred evenly, stirring thing is obtained, counts in parts by weight,
10 ~ 15 parts of soybean lecithins, 5 ~ 7 parts of stirring things, 3 ~ 5 parts of cholesterol, 1 ~ 3 part of Tween 80,1 ~ 3 part of absolute ethyl alcohol are taken, by soybean
Lecithin, cholesterol are mixed, and are stirred evenly, and stirring thing, Tween 80, absolute ethyl alcohol is added, is placed in 40 ~ 45 DEG C of temperature
It is vibrated in water-bath, obtains oscillation liquid, in mass ratio 1：5 ~ 7, oscillation liquid is injected into phosphate buffer, is placed in 40 ~ 45 DEG C of water
Rotary evaporation in vacuo in bath, processing, is then sonicated, as B phases；
（4）In mass ratio 1：7 ~ 9, chitin, sodium hydroxide solution are mixed, the 12 of chitin quality 8 ~ 10% are added
Sodium alkyl sulfate freezes at temperature -20 ~ -15 DEG C, obtains frozen material, in mass ratio 1：5 ~ 8, by frozen material, isopropanol in temperature
It is mixed at 20 ~ 25 DEG C, adjusts pH value to 7, filtering obtains filter residue, filter residue is washed with ethyl alcohol, obtains washings, in mass ratio 1：5：
10, washings, water, acetone are subjected to mixed precipitation, filtering obtains filter residue a, and filter residue a is dried at 50 ~ 60 DEG C of temperature, must be dried
Dry；
（5）In mass ratio 1：3 ~ 5, drying object, water are mixed, are heated to 70 ~ 80 DEG C, homogeneous is kept the temperature, as A phases, by matter
Measure ratio 1：0.8, under agitation, B phases are added into A phases, are heated to 50 ~ 70 DEG C, the thickening of A phases quality 0.7 ~ 0.9% is added
Homogeneous is stirred in agent, is cooled to 40 ~ 45 DEG C, and the resveratrol of A phases quality 0.1 ~ 0.2% is added, vacuumizes, and stirs homogeneous, filtering
Discharging collects paste to get acne eliminating cream.
2. the preparation method of acne eliminating cream according to claim 1, which is characterized in that the step（1）Middle mixed liquor is by matter
Measure ratio 1：0.5, petroleum ether, chloroform are uniformly mixed to get mixed liquor.
3. the preparation method of acne eliminating cream according to claim 1, which is characterized in that the step（3）Middle phosphate buffer
It is in mass ratio 6：1：70 ~ 80, sodium dihydrogen phosphate, disodium hydrogen phosphate, water are mixed to get phosphate buffer.
4. the preparation method of acne eliminating cream according to claim 1, which is characterized in that the step（5）Middle thickener is by matter
Measure ratio 5：3, tartaric acid, coconut oil diethanol amide are uniformly mixed to get thickener.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114903947A (en) * | 2022-05-14 | 2022-08-16 | 广州南雪药业有限公司 | Composition with acne removing effect and application thereof in preparation of medicines or skin care products |
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| CN1957924A (en) * | 2006-11-22 | 2007-05-09 | 上海微纳科技有限公司 | Nano liposome of tea plant oil, and preparation method |
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| CN1957924A (en) * | 2006-11-22 | 2007-05-09 | 上海微纳科技有限公司 | Nano liposome of tea plant oil, and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114903947A (en) * | 2022-05-14 | 2022-08-16 | 广州南雪药业有限公司 | Composition with acne removing effect and application thereof in preparation of medicines or skin care products |
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