CN108272904A - The portrait or photograph of the deceased rings low anesthesia plant extracts and its manufacturing method after a kind of - Google Patents
The portrait or photograph of the deceased rings low anesthesia plant extracts and its manufacturing method after a kind of Download PDFInfo
- Publication number
- CN108272904A CN108272904A CN201810362979.5A CN201810362979A CN108272904A CN 108272904 A CN108272904 A CN 108272904A CN 201810362979 A CN201810362979 A CN 201810362979A CN 108272904 A CN108272904 A CN 108272904A
- Authority
- CN
- China
- Prior art keywords
- extract
- powder
- solution
- mixed
- henbane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010002091 Anaesthesia Diseases 0.000 title claims abstract description 31
- 230000037005 anaesthesia Effects 0.000 title claims abstract description 31
- 239000000419 plant extract Substances 0.000 title claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 59
- 239000000243 solution Substances 0.000 claims abstract description 34
- 239000000284 extract Substances 0.000 claims abstract description 33
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract description 20
- 240000007551 Boswellia serrata Species 0.000 claims abstract description 20
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract description 20
- 241000208296 Datura Species 0.000 claims abstract description 20
- 239000004863 Frankincense Substances 0.000 claims abstract description 20
- 241000208278 Hyoscyamus Species 0.000 claims abstract description 20
- 235000006965 Commiphora myrrha Nutrition 0.000 claims abstract description 12
- 235000007265 Myrrhis odorata Nutrition 0.000 claims abstract description 12
- 240000007311 Commiphora myrrha Species 0.000 claims abstract description 9
- 239000011259 mixed solution Substances 0.000 claims abstract description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 48
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 24
- 239000000843 powder Substances 0.000 claims description 23
- 235000019441 ethanol Nutrition 0.000 claims description 20
- 238000000605 extraction Methods 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 14
- 239000007864 aqueous solution Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000011812 mixed powder Substances 0.000 claims description 12
- 239000000377 silicon dioxide Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 11
- 239000007787 solid Substances 0.000 claims description 11
- 241001057584 Myrrha Species 0.000 claims description 8
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 5
- 230000009514 concussion Effects 0.000 claims description 4
- 238000003810 ethyl acetate extraction Methods 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 239000002893 slag Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 241000196324 Embryophyta Species 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 12
- 230000003444 anaesthetic effect Effects 0.000 abstract description 6
- 206010012335 Dependence Diseases 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 4
- 230000002588 toxic effect Effects 0.000 abstract description 4
- 239000003814 drug Substances 0.000 description 11
- 208000002193 Pain Diseases 0.000 description 8
- 230000036407 pain Effects 0.000 description 7
- 235000021419 vinegar Nutrition 0.000 description 6
- 239000000052 vinegar Substances 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 5
- 229920006395 saturated elastomer Polymers 0.000 description 5
- 238000007654 immersion Methods 0.000 description 4
- 240000009023 Myrrhis odorata Species 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 2
- LFYBMMHFJIAKFE-PMEKXCSPSA-N acetorphine Chemical compound O([C@H]1[C@@]2(OC)C=C[C@@]34C[C@@H]2[C@](C)(O)CCC)C2=C5[C@]41CCN(C)[C@@H]3CC5=CC=C2OC(C)=O LFYBMMHFJIAKFE-PMEKXCSPSA-N 0.000 description 2
- XBMIVRRWGCYBTQ-UHFFFAOYSA-N acetylmethadol Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(OC(C)=O)CC)C1=CC=CC=C1 XBMIVRRWGCYBTQ-UHFFFAOYSA-N 0.000 description 2
- 229950005506 acetylmethadol Drugs 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010016326 Feeling cold Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000010513 Stupor Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004081 narcotic agent Substances 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000003236 psychic effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of rear portraits or photograph of the deceased to ring low anesthesia plant extracts and its manufacturing method, includes component A and component B two parts in the plant extracts；Wherein component A is specially datura flower and henbane real in mass ratio 1.3：0.7 mixed extract ethanol solution；Component B is specially frankincense and myrrh in mass ratio 1：1 mixed solution of extract.Anaesthetic effect of the present invention is good, toxic side effect is low, part is metabolizable, the solution that can partly wake up, anesthesia duration is moderate, is reacted without cause addiction.
Description
Technical field
The present invention relates to pharmaceutical technology fields more particularly to a kind of rear portrait or photograph of the deceased to ring low anesthesia plant extracts and its system
Make method.
Background technology
It is generally believed that anesthesia be a kind of nervous centralis generated by drug or other methods and（Or）Peripheral nervous system
The characteristics of invertibity function inhibitio, this inhibition is mainly the forfeiture for feeling the especially pain sensation.Anesthesia（anesthesia）One word
Derived from Greek narkosis, as its name suggests, fiber crops are numb paralysis, and liquor-saturated is drunk stupor.Therefore, anesthesia, which is meant that, uses drug
Or other methods keep patient whole or part is temporarily lost with feeling, to achieve the purpose that painless progress operative treatment.Anesthesiology
（anesthesiology）It is to use basic theory, clinical knowledge and technology in relation to anaesthetizing to eliminate corrective surgery pain, protects
Patient safety is demonstrate,proved, for a science to create good conditions of performing the operation.Now, anesthesiology have become in clinical medicine one it is special
Independent educational project, mainly include Clinical Anaesthesiology, emergency resuscitation medicine, Intensive care acology, Diagnosis and Treatment of Pain and other phases
The research for closing medicine and its mechanism is a research anesthesia, eases pain, the comprehensive branch of learning of emergency resuscitation and severe medicine.
Common narcotics has Acetorphine, acetyl Ah method Methyfentanyl, Acetylmethadol etc., is continuous use, indiscriminate
With or unreasonable use, be also easy to produce physical dependence and psychic dependence, can be at the drug of addiction.
Therefore, be badly in need of on the market a kind of anaesthetic effect is good, toxic side effect is low, part is metabolizable, the solution that can partly wake up, anesthesia when
Long moderate, without cause addiction reaction the rear portrait or photograph of the deceased rings low anesthesia plant extracts.
Invention content
In view of the above defects of the prior art, the present invention is intended to provide a kind of anaesthetic effect is good, toxic side effect is low,
Part is metabolizable, the solution that can partly wake up, anesthesia duration it is moderate, without cause addiction reaction the rear portrait or photograph of the deceased ring low anesthesia plant extracts and
Its manufacturing method.
To achieve the goals above, the present invention uses following technical scheme：The portrait or photograph of the deceased rings low anesthesia and is carried with plant after a kind of
The manufacturing method for taking object, includes the following steps：
1）Using the method for ultrasonic wave ethyl acetate extraction+ethanol solution extraction, datura flower and henbane reality extract are produced, specifically
For：
1. selecting datura flower and henbane to do solid work goods, by 1.3:Then 0.7 mass ratio mixing is cleaned, is dried for use, obtains for use
Mixture A；
2. being shredded 1. for use mixture A that step obtains to granularity 1-2mm using mechanical system, for use powder is obtained, together
When in addition to prepare enough grain sizes be 50 μm -200 μm of fine silica powder；
3. with for use powder：Ethyl acetate is by weight 1：Ethyl acetate is added in the ratio of 6-8, obtains mixed liquor, then mixing
2. fine silica powder that 20% step prepares is added in liquid in mass ratio, obtains for use mixed liquor；
4. 3. for use mixed liquor that step obtains is placed under 50 DEG C of -70 DEG C of environment, and using the ultrasonic wave of 500-600W power
Generator carries out ultrasonic wave extraction to the mixed liquor, and extraction time 5h-8h is partly steamed from obtaining solid content after ethyl acetate
The concentrated extracting solution of 60%-80%；
5. the absolute ethyl alcohol of 1-1.2 times of concentrated extracting solution volume is added in 4. concentrated extracting solution that step obtains, it is quiet after concussion
Layering is set, after the ethyl acetate solution, the solid disintegrating slag of bottom and the fine silica powder of bottom that remove upper layer liquid layer, acquisition
Lower layer's liquid layer is required datura flower and henbane reality extract ethanol solution；
2）Using Microwave Extraction frankincense and Myrrha extract, specially：
1. frankincense and Myrrh are selected, by 1:Then 1 mass ratio mixing is cleaned, dries for use, for use mixing of acquisition
Powder；
2. being put into 1. for use mixed-powder that step obtains by weight the pure water for being 50 times -60 times of for use mixed-powder
In；
3. being put into the microwave ring of 800W-1000W after the 2. for use mixed-powder mixture of pure water that step obtains is stirred evenly
It in border, and maintains to stir, extraction time 5min-8min, the aqueous solution of acquisition is required frankincense and Myrrha extract aqueous solution；
3）Pharmacy
1. by the stage 1）The datura flower and henbane reality extract ethanol solution of acquisition and stage 2）The frankincense and myrrh of acquisition extract
Object aqueous solution by volume 1：6-7 is uniformly mixed, and using the infinitely dissolve of water and ethyl alcohol, miscible fluid is made, which is
The portrait or photograph of the deceased rings low anesthesia plant extracts after required.
The rear portrait or photograph of the deceased manufactured using the above method rings low anesthesia plant extracts, includes component in the plant extracts
A and component B two parts；Wherein component A is specially datura flower and henbane real in mass ratio 1.3：0.7 mixed extract ethyl alcohol
Solution；Component B is specially frankincense and myrrh in mass ratio 1：1 mixed solution of extract.
The application method of the present invention is to be generated subsequently into blood by lung incoming call after being atomized the present invention using atomizer
The effect of whole body analgesia anesthesia, respiratory time 10min-15min, duration 4-6 hours only need to use when if quickly need to wake up liquor-saturated
Radix Glycyrrhizae, infusion of tea obtain vinegar immersion liquid in vinegar, and big portion fiber crops can be released in 5 minutes by being sucked after vinegar immersion liquid is atomized
Liquor-saturated effect.
Compared with the prior art, the present invention as the above scheme is adopted, has the following advantages：（1）Different from existing skill
Art largely uses the poisonous and harmful medicine of the chemical syntheses such as Acetorphine, acetyl Ah method Methyfentanyl, Acetylmethadol or chemical industry extraction
Agent, all components of the invention can be extracted from the extensive flora in source, nonhazardous, without side-effects.（2）Henbane can rush in fact
The popular feeling, big unhappy, look unfamiliar Xian fire, has relieving spasm and pain when mixed with alcohol, the effect of tranquilizing the mind analgesic therapy is can to enter lung channel simply
Arcotic.（3）Datura flower has relieving cough and asthma, relieves pain calm effect, be usually used in asthma and cough, coldness and pain in the epigastrium, arthralgia pain due to rheumatism,
Infantile chronic fright and surgical anesthesia mainly enter the anaesthetic effect of whole body using it from lung channel when for the present invention, with the present invention's
Technical purpose is harmonious.（4）Written by the famous doctor Liu Wansu of Jin and Yuan dynasty《Declare opinion》In interior " Pain-Stopping Pill " just include frankincense and
Myrrh, this two tastes medicine can generate anaesthetic effect when being shared described in Chinese medicine warp, but oral dose is big and of high cost, therefore apply
Seldom, with the development of modern medicine, it is water-soluble components that people, which develop their anesthesia to share composition, therefore by water-soluble
Liquid Microwave Extraction can obtain the anesthesia composition that high activity easily absorbs, and equally be passed through lung channel.（5）All compositions can be exhaled by lung
Enter, the effect of whole body analgesia anesthesia is generated subsequently into blood, duration about 4 hours only needs to use when if quickly need to wake up liquor-saturated
Radix Glycyrrhizae, infusion of tea obtain vinegar immersion liquid in vinegar, and big portion fiber crops can be released in 5 minutes by being sucked after vinegar immersion liquid is atomized
Liquor-saturated effect, anaesthetic effect is good, toxic side effect is low, part is metabolizable, the solution that can partly wake up, anesthesia duration is moderate, is reacted without cause addiction.
Specific implementation mode
Embodiment 1：
The portrait or photograph of the deceased rings low anesthesia plant extracts after a kind of, includes component A and component B two parts in the plant extracts；Its
Middle component A is specially datura flower and henbane real in mass ratio 1.3：0.7 mixed extract ethanol solution；Component B is specially
Frankincense and myrrh in mass ratio 1：1 mixed solution of extract.
The portrait or photograph of the deceased rings the manufacturing method of low anesthesia plant extracts after above-mentioned, includes the following steps：
1）Using the method for ultrasonic wave ethyl acetate extraction+ethanol solution extraction, datura flower and henbane reality extract are produced, specifically
For：
1. selecting datura flower and henbane to do solid work goods, by 1.3:Then 0.7 mass ratio mixing is cleaned, is dried for use, obtains for use
Mixture A；
2. being shredded 1. for use mixture A that step obtains to granularity 1-2mm using mechanical system, for use powder is obtained, together
When in addition to prepare enough grain sizes be 50 μm -100 μm of fine silica powder；
3. with for use powder：Ethyl acetate is by weight 1：Ethyl acetate is added in 6 ratio, obtains mixed liquor, then in mixed liquor
2. fine silica powder that 20% step prepares inside is added in mass ratio, obtains for use mixed liquor；
4. 3. for use mixed liquor that step obtains is placed under 50 DEG C of environment, and using the supersonic generator of 500W power to institute
It states mixed liquor and carries out ultrasonic wave extraction, extraction time 5h is partly steamed from the concentration extraction for obtaining solid content 60% after ethyl acetate
Liquid；
5. the absolute ethyl alcohol of 1 times of concentrated extracting solution volume is added in 4. concentrated extracting solution that step obtains, stands and divide after concussion
Layer, after the ethyl acetate solution, the solid disintegrating slag of bottom and the fine silica powder of bottom that remove upper layer liquid layer, the lower layer of acquisition
Liquid layer is required datura flower and henbane reality extract ethanol solution；
2）Using Microwave Extraction frankincense and Myrrha extract, specially：
1. frankincense and Myrrh are selected, by 1:Then 1 mass ratio mixing is cleaned, dries for use, for use mixing of acquisition
Powder；
2. being put into 1. for use mixed-powder that step obtains by weight in the pure water of 50 times of for use mixed-powder；
3. it is put into the microwave environment of 800W after the 2. for use mixed-powder mixture of pure water that step obtains is stirred evenly, and
Stirring is maintained, the aqueous solution of extraction time 5min, acquisition are required frankincense and Myrrha extract aqueous solution；
3）Pharmacy
1. by the stage 1）The datura flower and henbane reality extract ethanol solution of acquisition and stage 2）The frankincense and myrrh of acquisition extract
Object aqueous solution by volume 1：6 are uniformly mixed, and using the infinitely dissolve of water and ethyl alcohol, miscible fluid are made, which is institute
The portrait or photograph of the deceased rings low anesthesia plant extracts after needing.
Embodiment 2：
It is whole consistent with embodiment 1, it is in place of difference
The portrait or photograph of the deceased rings the manufacturing method of low anesthesia plant extracts after a kind of, includes the following steps：
1）Using the method for ultrasonic wave ethyl acetate extraction+ethanol solution extraction, datura flower and henbane reality extract are produced, specifically
For：
2. being shredded 1. for use mixture A that step obtains to granularity 1-2mm using mechanical system, for use powder is obtained, together
When in addition to prepare enough grain sizes be 100 μm -200 μm of fine silica powder；
3. with for use powder：Ethyl acetate is by weight 1：Ethyl acetate is added in 8 ratio, obtains mixed liquor, then in mixed liquor
2. fine silica powder that 20% step prepares inside is added in mass ratio, obtains for use mixed liquor；
4. 3. for use mixed liquor that step obtains is placed under 70 DEG C of environment, and using the supersonic generator of 600W power to institute
It states mixed liquor and carries out ultrasonic wave extraction, extraction time 8h is partly steamed from the concentration extraction for obtaining solid content 80% after ethyl acetate
Liquid；
5. the absolute ethyl alcohol of 1.2 times of concentrated extracting solution volume is added in 4. concentrated extracting solution that step obtains, stood after concussion
It is layered, after the ethyl acetate solution, the solid disintegrating slag of bottom and the fine silica powder of bottom that remove upper layer liquid layer, under acquisition
Layer liquid layer is required datura flower and henbane reality extract ethanol solution；
2）Using Microwave Extraction frankincense and Myrrha extract, specially：
2. being put into 1. for use mixed-powder that step obtains by weight in the pure water of 60 times of for use mixed-powder；
3. it is put into the microwave environment of 1000W after the 2. for use mixed-powder mixture of pure water that step obtains is stirred evenly,
And maintain to stir, extraction time 8min, the aqueous solution of acquisition is required frankincense and Myrrha extract aqueous solution；
3）Pharmacy
1. by the stage 1）The datura flower and henbane reality extract ethanol solution of acquisition and stage 2）The frankincense and myrrh of acquisition extract
Object aqueous solution by volume 1：7 are uniformly mixed, and using the infinitely dissolve of water and ethyl alcohol, miscible fluid are made, which is institute
The portrait or photograph of the deceased rings low anesthesia plant extracts after needing.
The foregoing description of the disclosed embodiments, only for enabling professional and technical personnel in the field to realize or using this hair
It is bright.Various modifications to these embodiments will be apparent to those skilled in the art, and determine herein
The General Principle of justice can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, originally
Invention is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein
Consistent widest range.
Claims (2)
1. the portrait or photograph of the deceased rings the manufacturing method of low anesthesia plant extracts after a kind of, it is characterised in that include the following steps：
1）Using the method for ultrasonic wave ethyl acetate extraction+ethanol solution extraction, datura flower and henbane reality extract are produced, specifically
For：
1. selecting datura flower and henbane to do solid work goods, by 1.3:Then 0.7 mass ratio mixing is cleaned, is dried for use, obtains for use
Mixture A；
2. being shredded 1. for use mixture A that step obtains to granularity 1-2mm using mechanical system, for use powder is obtained, together
When in addition to prepare enough grain sizes be 50 μm -200 μm of fine silica powder；
3. with for use powder：Ethyl acetate is by weight 1：Ethyl acetate is added in the ratio of 6-8, obtains mixed liquor, then mixing
2. fine silica powder that 20% step prepares is added in liquid in mass ratio, obtains for use mixed liquor；
4. 3. for use mixed liquor that step obtains is placed under 50 DEG C of -70 DEG C of environment, and using the ultrasonic wave of 500-600W power
Generator carries out ultrasonic wave extraction to the mixed liquor, and extraction time 5h-8h is partly steamed from obtaining solid content after ethyl acetate
The concentrated extracting solution of 60%-80%；
5. the absolute ethyl alcohol of 1-1.2 times of concentrated extracting solution volume is added in 4. concentrated extracting solution that step obtains, it is quiet after concussion
Layering is set, after the ethyl acetate solution, the solid disintegrating slag of bottom and the fine silica powder of bottom that remove upper layer liquid layer, acquisition
Lower layer's liquid layer is required datura flower and henbane reality extract ethanol solution；
2）Using Microwave Extraction frankincense and Myrrha extract, specially：
1. frankincense and Myrrh are selected, by 1:Then 1 mass ratio mixing is cleaned, dries for use, for use mixing of acquisition
Powder；
2. being put into 1. for use mixed-powder that step obtains by weight the pure water for being 50 times -60 times of for use mixed-powder
In；
3. being put into the microwave ring of 800W-1000W after the 2. for use mixed-powder mixture of pure water that step obtains is stirred evenly
It in border, and maintains to stir, extraction time 5min-8min, the aqueous solution of acquisition is required frankincense and Myrrha extract aqueous solution；
3）Pharmacy
1. by the stage 1）The datura flower and henbane reality extract ethanol solution of acquisition and stage 2）The frankincense and myrrh of acquisition extract
Object aqueous solution by volume 1：6-7 is uniformly mixed, and using the infinitely dissolve of water and ethyl alcohol, miscible fluid is made, which is
The portrait or photograph of the deceased rings low anesthesia plant extracts after required.
2. ringing low anesthesia plant extracts using the rear portrait or photograph of the deceased of claim 1 the method manufacture, it is characterised in that：The plant
Include component A and component B two parts in object extract；Wherein component A is specially datura flower and henbane real in mass ratio 1.3：0.7
Mixed extract ethanol solution；Component B is specially frankincense and myrrh in mass ratio 1：1 mixed solution of extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810362979.5A CN108272904A (en) | 2018-04-21 | 2018-04-21 | The portrait or photograph of the deceased rings low anesthesia plant extracts and its manufacturing method after a kind of |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810362979.5A CN108272904A (en) | 2018-04-21 | 2018-04-21 | The portrait or photograph of the deceased rings low anesthesia plant extracts and its manufacturing method after a kind of |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108272904A true CN108272904A (en) | 2018-07-13 |
Family
ID=62812015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810362979.5A Pending CN108272904A (en) | 2018-04-21 | 2018-04-21 | The portrait or photograph of the deceased rings low anesthesia plant extracts and its manufacturing method after a kind of |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108272904A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647906A (en) * | 2009-08-31 | 2010-02-17 | 李龙 | Preparation containing henbane and daturaflower for treating cancer pain and surgery wound pain |
| BRPI0904832A2 (en) * | 2009-09-25 | 2011-05-24 | Universidade Federal De Santa Maria | plant extract anesthetic compositions for aquatic animals and method of sedation and / or anesthesia of aquatic animals comprising the same |
| CN104491256A (en) * | 2014-12-30 | 2015-04-08 | 青岛市肿瘤医院 | Multi-effect local anesthetic |
| CN104491166A (en) * | 2014-12-30 | 2015-04-08 | 青岛市肿瘤医院 | Traditional Chinese medicine composition with auxiliary anesthetic effect |
-
2018
- 2018-04-21 CN CN201810362979.5A patent/CN108272904A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647906A (en) * | 2009-08-31 | 2010-02-17 | 李龙 | Preparation containing henbane and daturaflower for treating cancer pain and surgery wound pain |
| BRPI0904832A2 (en) * | 2009-09-25 | 2011-05-24 | Universidade Federal De Santa Maria | plant extract anesthetic compositions for aquatic animals and method of sedation and / or anesthesia of aquatic animals comprising the same |
| CN104491256A (en) * | 2014-12-30 | 2015-04-08 | 青岛市肿瘤医院 | Multi-effect local anesthetic |
| CN104491166A (en) * | 2014-12-30 | 2015-04-08 | 青岛市肿瘤医院 | Traditional Chinese medicine composition with auxiliary anesthetic effect |
Non-Patent Citations (2)
| Title |
|---|
| 傅超美等主编: "《中药药剂学》", 31 August 2014, 中国医药科技出版社 * |
| 庞俊忠主编: "《临床中药学》", 30 September 1989, 中国医药科技出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Sanders | Inhalation therapy: an historical review | |
| CN103768541B (en) | A kind of medicine for the treatment of chronic bronchitis | |
| CN105687285A (en) | Incense and preparation method thereof | |
| CN100558392C (en) | The liniment of treatment infantile pneumonia, bronchitis and asthma | |
| CN105168500B (en) | It is a kind of to be used to treat pharmaceutical composition of dental ulcer of infant and preparation method thereof | |
| CN108272904A (en) | The portrait or photograph of the deceased rings low anesthesia plant extracts and its manufacturing method after a kind of | |
| CN1454645A (en) | External-use Chinese medicine preparation for wind-dispelling and dampness-removing and preparing method thereof | |
| CN103768552A (en) | Medicine for treating asthma | |
| CN103816448B (en) | A kind of Chinese medicine composition treating pulmonary tuberculosis | |
| CN106692822A (en) | Traditional Chinese medicine pills for treating tracheobronchitis | |
| CN103751307B (en) | A kind of external application analgesic Chinese patent medicine and preparation technology thereof | |
| CN1778329B (en) | Medicine for treating hydrophobia and processing method thereof | |
| CN102836306B (en) | Traditional Chinese medicine combination for treating horse traumatic injuries and preparation method of same | |
| CN108465036A (en) | A kind of remedy,toothache and middle powder stick item | |
| JPH11180889A (en) | Agent for treating dermatitis containing extracted ingredient from ganoderma lucidum karst. | |
| CN108704042A (en) | Has effects that medicinal vesiculation preparation of reducing pressure and sugar and preparation method thereof | |
| CN108938879A (en) | A kind of set a broken bone blood-activating and pain-stopping capsules and its preparation process | |
| CN106805286A (en) | A kind of Chinese medicine cigar for treating bronchial astehma | |
| CN107714909A (en) | A kind of Chinese medicine composition for treating chronic bronchitis, bronchitis, asthma, pulmonary emphysema and preparation method thereof | |
| CN106038711A (en) | Traditional Chinese medicine composition for preventing and treating premature ejaculation as well as preparation method and preparation thereof | |
| CN107362207A (en) | A kind of medicament for treating scald | |
| CN108324766A (en) | A kind of anesthesia plant extracts being easily metabolized and its manufacturing method | |
| CN105687424A (en) | Ointment for treating traumatic injuries | |
| CN102908493A (en) | Emergency drug for treating hydrophobia | |
| CN104043074A (en) | Traditional Chinese medicine preparation for treating enduring cough for many years |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180713 |
|
| RJ01 | Rejection of invention patent application after publication |