CN108254494A - The device of analyte in a kind of detection sample - Google Patents
The device of analyte in a kind of detection sample Download PDFInfo
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- CN108254494A CN108254494A CN201711276092.6A CN201711276092A CN108254494A CN 108254494 A CN108254494 A CN 108254494A CN 201711276092 A CN201711276092 A CN 201711276092A CN 108254494 A CN108254494 A CN 108254494A
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01V—GEOPHYSICS; GRAVITATIONAL MEASUREMENTS; DETECTING MASSES OR OBJECTS; TAGS
- G01V9/00—Prospecting or detecting by methods not provided for in groups G01V1/00 - G01V8/00
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Geophysics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention provides a kind of device for detecting analyte in sample, which includes：The collecting chamber of liquid sample is received, which includes an opening；For the testing element of analyte in test liquid samples；With for cover close collecting chamber opening cover；Wherein further include whether a prompting cover covers the suggestion device closed to designated position on collecting chamber on device, wherein, the suggestion device is prompted by making a sound, wherein, the suggestion device includes a non-elastic member and elastic element, wherein the non-elastic member is located on collecting chamber, elastic element is in cover, wherein, the elastic element is a part for cover.It is detected using the present apparatus, it is easy to operate.
Description
Technical field
The present invention relates to a kind of for detecting the detection device that whether there is analyte in liquid sample, more particularly to logical
It crosses the beginning for generating auditory tone cues detection device or lid closes the detection device completed.
Background technology
In medical health field, detection body fluid is a universal behavior.Factory, government organs, team and other groups
Knit more and more the safety in maintenance work place and is ensured in accordance with law, regulation and article using diagnostic test.
Liquid sample, such as urine are collected, and judge whether specific analyte (such as drugs using detection device
And/or its metabolin or with the relevant marker of disease) as a kind of very universal method.The device tested in this way is general
It is required that sample is collected in sample container, related technical personnel are inserted into a test strip and flood a part for test strips
In the sample, test strips are then taken out and reads result.Technical staff may touch sample, and possible entail dangers to is healthy or makes sample
This is contaminated.To avoid this risk, need to be operated after adding closure body on sample collection container.At present, it has deposited
There are many obturators, such as United States Patent (USP) US 4,976,923, US 5,429,804 and US 6,726,879 is revealed
Device.These devices are that test strip is fixed on the lid of detection device.In use, container, which is overturn, or is tilted makes
Sample infiltration test strip is detected.U.S. Patent Application Publication US2003/0027359A1 is disclosed on 2 6th, 2003
A kind of detection urine cup.The detection urine cup still needs to be pushed pillar piston motion with push rod and made after the opening of lid lid to cup
Fluid sample flows out from cup cavity and moistens detecting element.Patent application 200510113977.5 discloses disclosed in China
A kind of detection urine cup.Detection urine cup start liquid after the opening of lid lid to cup flows to test chamber from collecting chamber, so as to
Start the beginning of detection.In patent application disclosed in another China's application, 200480033286.8 also reveal a kind of inspection
Survey urine cup.Detection urine cup starts the beginning of detection after the opening of lid lid to cup.
Recently, this detection device is used by average family or amateur mechanism more and more.Due to these inspections
Test and appraisal, which are estimated, to be aimed at designed by layman, so these detection devices need to make operating process simple, and can guarantee inspection
Survey the accuracy of result.Current, occurred starting by generating auditory tone cues detection device in the market or lid
Lid closes the device to pre-set position, such test device in Chinese Patent Application No. 201110115654.5,
200910225108.X with 201310582566.5 in had specific description.These devices can be operator oneself behaviour
Make, when the conjunction of lid lid is open to cup body, make a sound that operator is allowed to stop rotating by mechanical structure, so as to more hold
Easily achieve the purpose that detection, increase the degree of belief of operator and avoid the problem that additional.
In Chinese patent 201110115654.5, in this application, disclose after shrapnel is distorted, reply original form
During, it shakes and makes a sound, which voluntarily decays.It is retouched in 200910225108.X and 201310582566.5
It states, elastic element deforms upon after non-elastic member, then restores to tap cover during original state and send out
Go out sound.Although can make a sound above, it is required for additionally increasing structure, and the relatively elaborate gas that operates,
Along with production difficulty height, especially for plastics disposable product, there are die cost it is high the defects of.
Therefore, accurately and reliably detection device is needed for present society is to easy to operate and testing result.The present invention is just
It is to provide a kind of detection device for meeting this demand, to existing traditional improvement of detecting device.
Invention content
The present invention provides a kind of detection device easy to operate.Concretely, a kind of detection urine cup easy to operate is provided.
After the opening of the lid lid of urine cup to cup, a suggestion device, device prompting lid are further included on detection urine cup
Whether lid is closed to designated position.On the one hand, it is closed all in the opening of cup when lid lid, due to different operators, particularly
Those laymans can cause lid lid to close the tightness difference being open to cup, this this may result in some lids not
The opening of cup can be sealed well, some detection urine cups have the possibility of leakage.
The present invention sets a suggestion device on detection means, when lid lid is closed to designated position on collecting chamber
(position may be considered that cover is enough to seal the opening of collecting chamber), suggestion device prompting lid have sealed collecting chamber
Opening, operator no longer needs lid closing lid body.The opening of each device can in this way be totally sealed off and does not have to worry
The problem of leakage.On the other hand, in some devices, lid is after lid is closed onto the opening of collecting chamber, the liquid in collecting chamber
Body sample is detected with regard to engaged test element.In traditional detection urine cup, it is typically necessary starts the clock at this time, etc.
Test result on to read test element after a certain period of time in detection zone.When different operation person is operated, from
It is specific when to start the clock neither one unanimously and unified standard, same device to different operators and
Speech, may lead to different testing results.The present invention provides a kind of detection device, when lid lid is closed to designated position on collecting chamber
When, suggestion device sends out a prompt message, such as a kind of sound, which tells operator can start to calculate to read
The time that the needs of test result on testing element wait for.
On the one hand, the present invention provides a kind of device for detecting and whether there is analyte in sample, including：Collecting chamber, should
Collecting chamber includes the opening for being used for collecting liquid sample；With, for cover close collecting chamber opening cover；Wherein also wrapped on device
Include whether prompting cover covers the suggestion device closed to designated position.
In some preferred modes, when cover cap is closed to designated position, suggestion device prompting cover is close
The opening of collecting chamber is sealed.Alternatively, further including testing element in a device, which can contact progress with liquid sample
In liquid sample the test of analyte and chemical examination, when cover cap close to designated position when, suggestion device prompting
Start to calculate the time that the testing result needs on read test element wait for.
In some preferred modes, suggestion device is prompted by making a sound.In some specific modes,
Suggestion device includes some elements, these elements can be made a sound by being collided after elastic deformation.Specifically, suggestion device packet
Include two elements, after the first and second two elements contact with each other, it is one of elastic deformation occurs after spring back collision again in addition
Third element make a sound to be prompted.In a specific mode, the first element that suggestion device includes is elasticity
Element and second element are non-elastic member, and when elastic element passes through non-elastic member, elastic element is by non-elastic member pressure
Compel to become and elastic deformation occurs, after the power that is oppressed disappears, elastic element springs back make a sound again, this rebound can collide,
It taps other third element or elastic element and non-elastic member is mutually collided and made a sound.Here third element can
To be element that the element of individualism is either present in cup body or cover or form the one of cup body or cover
Part-structure.
It is furthermore preferred that on the outer surface of cover rim that elastic element can be located at cover；Non-elastic member can also be located at cup
In the outer wall surface of mouth.More specifically in embodiment, a part of the elastic element for the cover rim of cover, in no generation shape
Before change, the elastic element on cover rim is a part for cover, but links together with cover.Concretely, in order to elasticity
Element is arranged in cover, a part is separated out on cover rim as elastic element, general cover rim is interior to have internal thread structure, should
There is interval between the other departments in part and cover rim separated, this interval can be 1-2 mm wides, alternatively, separated
Partial both sides all have interval all between the other parts of cover rim, and are connect with one side with cover rim.Such as separated
Partly (elastic element is in itself) is about 1/20th or smaller of cover rim, generally rectangle structure, is separated on cover rim
Side and the cover rim of length of part separate, short one side is connect with cover, it is another it is short while the exposed cover rim as cover while,
Referred to as exposed side.Such structure can generally be reached by being molded disposable tool.
Preferably, non-elastic member is set on cup body, longitudinal general parallel orientation of the non-elastic member and cup body, but should
Non-elastic member slightly towards cup body tilt, in this way when cover cap close rim of a cup when, the non-elastic member protrude one end or
Exposed one end is contacted with the exposed side inside of elastic element in cover or inner surface, non-as cover swivelling cover closes rim of a cup
Elastic element continues the exposed side interior side contacts with elastic element in cover, since non-elastic member hardly deforms upon, and
Elastic element in cover encounters the strength pushed out, natural to protrude outside the lid of cover or be referred to as to stick up, should
Elastic element is general rectangular, and long both sides have interval with cover rim, so as to be stuck up to the face of circumference where cover rim other parts
Get up, (with the change of relative position) after non-elastic member is detached from elastic element, elastic element needs to reply original position
It puts, is made a sound so as to tap cup body.
In some more preferably mode, in the outer surface on the exposed side of the elastic element on cover rim or/h
With include stiff element or referred to as bulge-structure, the non-elastic member can be located at elastic element on inner surface
An exposed part on or when elastic element is exposed for stiff material, allow non-ballistic on cup body in this way
Property element is contacted with the non-elastic portion on elastic element, it is easier to elastic element be allowed to be denaturalized.
In a preferred mode, a non-elastic member is included on the exposed edge of elastic element, elasticity should be located at
Non-elastic member on element is contacted with the non-elastic member on cup body, so as to which elastic element be allowed to be easier to where cover rim
Face protrusion or tilt, so as to deform upon.Preferably, the downside of the non-elastic member on elastic element and cup body
On non-elastic member tip contact, allowed so as to allow elastic element be easier to where cover rim face protrusion or tilt.
In addition, non-elastic member and collecting chamber are relative to can synchronous movement counterclockwise with cover；Elastic element and cover phase
It pair can also synchronous movement clockwise with collecting chamber.In an optional scheme, on the elastic element and cup body in cover
Under non-elastic member interaction force, elastic deformation, after interaction force disappears, elastic element and non-phase occur for elastic element
The mutually sound of collision prompting.
In the specific mode of other, non-elastic member is made of ABS material；Elastic element is made of PP materials.
Optionally, elastic element is by non-elastic member and after beaing cup body, and elastic element is prevented by non-elastic member with cannot phase
Cup body is made mobile clockwise.In another optional mode, elastic element is by non-elastic member and after beaing cup body,
Elastic element can clockwise be moved relative to cover.Selectable, the mode that cover cap closes collecting chamber opening passes through for cover
The mode of rotation seals the opening of collecting chamber, opening includes external screw thread coordinate with cover, and cover includes and opening coordinates
Internal thread.
In some preferred modes, on the elastic element on cover rim do not have in the thread fitting of cup body outer
Screw thread.
On the other hand, the present invention provides a kind of method for detecting analyte in sample, including providing a kind of detection dress
It puts, including：One collecting chamber, which includes an opening for being used for collecting liquid sample and one is used for covering conjunction collection
The cover of chamber opening；Lid lid is closed onto the opening of collecting chamber, the suggestion device prompting cover allowed in detection device is
No lid is closed to designated position.In a mode, suggestion device is prompted by making a sound.In another mode,
Once hearing that suggestion device sends out prompting, stopping continues on lid closing lid body to the opening of collecting chamber.In a specific mode,
Cover seals the opening of collecting chamber by way of rotation, once hear that suggestion device sends out prompting, cover of stopping rotating.This
Outside, in a mode, once hearing that suggestion device sends out prompting, start to calculate on read test element required for testing result
The time of waiting.In another mode, once hearing that suggestion device sends out prompting, start to calculate and be detected on read test element
As a result the time of required waiting is simultaneously stopped rotation cover.
The present invention provides a kind of method for detecting analyte in sample, including：A kind of detection device is provided, the device
Contain the collecting chamber being open including one；One testing element；It is open with one with collecting chamber relative rotation to seal collecting chamber
Cover, wherein further including whether a prompting cover rotates to the suggestion device of designated position on device；It is straight to rotate cover
Prompting is sent out to suggestion device.
In some preferred modes, after suggestion device sends out prompting, stop rotating.Optionally, when suggestion device is sent out
After going out prompting, starting to calculate needs the testing result on read test element to need the time waited for.In a specific mode
In, suggestion device is prompted by making a sound.It is furthermore preferred that suggestion device includes one from collecting chamber outer surface protrusion
Non-elastic member and an elastic element from cover rim, the elastic element be cover cap edge a part, rotation cover
In the process, elastic element is allowed to deform after oppressing the exposed one side of non-resilient member, after non-elastic member is detached from elastic element,
Non-elastic member beats cup body and makes a sound.Most preferably, non-elastic member includes a raised structure, has centainly firm
Property, and contacted as cover cap along the exposed side of the elastic element of a part with the bulge-structure of non-elastic member, so as to outward
It tilts.
Advantageous effect
Apparatus and method of the present invention makes the operation of detection device simpler, and layman is suitble to use, is provided simultaneously
Testing result it is more accurate.In addition manufacture the device of the invention is of low cost, and operation is more prone to, without very big strength just
Clear and melodious sound can be sent out.
Description of the drawings
Figure 1A-Fig. 1 D are the theory structure schematic diagram of sounding in a specific embodiment of the invention.
Fig. 2A-Fig. 2 D are the theory structure schematic diagram of sounding in another specific embodiment of the invention.
Fig. 3 A- Fig. 3 D are the theory structure schematic diagram of sounding in another specific embodiment of the invention.
In the specific embodiment of the present invention of Fig. 4 positions, the dimensional structure diagram of cup body, non-elastic member is located at cup
On body.
Fig. 5 is the dimensional structure diagram of cover, in the cover of elastic element position in the specific embodiment of the present invention
And as a part for cover rim.
Fig. 6 is the cover rim for the cover that band has elastic component in the specific embodiment of the present invention (cover in Fig. 5)
The attached drawing in face.
Fig. 7 is the cover rim for the cover that band has elastic component in the specific embodiment of the present invention (cover in Fig. 5)
The dimensional structure diagram in face.
Fig. 8 A- Fig. 8 C are structure diagram of the cover cap conjunction to the process on cup body, and Fig. 8 A cover caps are closed onto cup body
The structure diagram of contact；Fig. 8 B are that elastic element stress is tilted to cover rim periphery；Fig. 8 C are non-elastic member and elastic element
Position relationship schematic diagram after disengaging.
Specific embodiment
Structure of the present invention or these used technical terms are described further below.
Detection
Detection represents chemical examination or tests a kind of substance or material whether there is, for example, but it is not limited to this, chemical substance,
The generation of organic compound, inorganic compound, metabolism product, drug or drug metabolite, organic organization or organic organization
Thank object, nucleic acid, protein or polymer.In addition, detection represents test substances or the quantity of material.Furtherly, table is gone back in chemical examination
Show immune detection, chemical detection, enzyme detection etc..
Detection device
In a specific example, detection device includes a collecting chamber 10 for being used for collecting and storing liquid sample, receives
Collection chamber is surrounded by side wall 101 and a bottom 102, and is used to import liquid sample including an opening 100.The explanation of the present invention
Book is construed as including one at least one or quantity, no including making a summary with "one" described in claim
The meaning of " unique " or " only only there are one " can be only understood as.For example, detection device includes a suggestion device, it is clear that
In detection device including the suggestion device of 2 or 2 or more should also drop into this hair the scope of the claims it is interior and not
Except being excluded.It can also include a test chamber 207 in detection device, include testing element in test chamber, in collecting chamber
Liquid sample be free to or controllably be contacted with the testing element in test chamber；Chemical reagent can be surveyed on testing element
It tries to whether there is analyte or existing quantity in liquid sample.It can also include a cover 30 on detection means, it should
Cover is used for covering the opening 100 for closing collecting chamber.In a specific mode, detection device includes a suggestion device, this is carried
Showing device can prompt whether cover covers conjunction to designated position, in more detail, prompt whether cover covers conjunction to the finger on collecting chamber
Positioning is put.On the one hand, when cover cap is closed to designated position on collecting chamber, suggestion device can prompt cover sealed
The opening of collecting chamber.On the other hand, when cover cap is closed to designated position on collecting chamber, suggestion device can prompt to start
Calculate the time waited for required for the test result on read test element.Cover cap conjunction has much to the mode on collecting chamber
Kind, such as lid closes in the form of screw thread.For example, the opening of collecting chamber includes external screw thread, cover includes coordinating with external screw thread
Internal thread；After cover cap is closed onto collecting chamber, by relative rotation come sealed opening.In addition it is also possible to it is with piston
Form, cover, which is inserted into opening, carrys out sealed opening.
The suggestion device of the present invention can also be applied in other detection devices, particularly, lid can be contained with those
Body is simultaneously sealed with cover in the device of the opening of collecting chamber；Similar devices other in this way are special in the U.S. having disclosed
Profit, US 7,270,959；US 7,300,633；US 7,560,272；US 7,438,852, US 4,976,923, US 5,
Have specific description in 429,804 and US, 6,726,879 grades, disclosed suggestion device may be incorporated into
One of concrete mode in the concrete mode of each detection device disclosed in upper patent as the present invention.
Suggestion device
In a concrete mode, suggestion device can be located at detection device on, suggestion device by make a sound come into
Row prompting.This sound can be " ", " bang ", " rub-a-dub ", " stining purine ", " pipa " or other any suitable sounds.
Suggestion device generally comprises element, and one is elastic element, and one is non-elastic member.The present invention is referred to herein
" elastic element " and " non-elastic member " it is an opposite concept.In setting, generally, the elastic feel quantity of elastic element
It is less than the elastic feel quantity of non-elastic member.For example, plastics is selected to select metal, such as iron, steel or lead are made as elastic element
For the material of non-elastic member, for such plastics under the power effect mutual with non-elastic member, the elastic feel quantity of elastic element will
Smaller than the elastic feel quantity of non-elastic member, under similar circumstances, relatively shape easily occurs the mutual power of the two for elastic element
The change of shape, after the power received is in pop-off, elastic element needs to restore to the original state, so as to beat third element (or cup body
On) or knock second element so as to generate vibration and make a sound.Here the power one suffered by elastically-deformable element occurs
As need to be less than the intrinsic elastic limit of the element, they can voluntarily restore to the original state after external force disappears in this way.It can
Choosing, elastic element and non-elastic member are all plastic material.
In some preferred modes, such as the structure shown in Figure 1A -1D, elastic element 30 is located in cover, as lid
A part for body particularly, belongs to a part for cover rim 30, the external screw thread cooperation of internal thread and cup body is included inside cover rim and is revolved
Turn the opening of sealing cup body.Elastic element 30 is the shape of general rectangular, two long sides and other longitudinal direction portions of cover rim 30
Divide 32,35 there is separation mouth, such short side is connected with cover rim, and another short side is hanging, as exposed side and the edge of cover rim
Side.When the non-elastic member 33 on cup body is by elastic element, due to non-elastic member and the close cup of elastic element
The one side (inner surface) 36 of body contacts (Figure 1B), and with the movement of relative position, elastic element can deform upon, from inside to outside
Deformation, since elastic element is by the outside power of principle cover rim plane, so as to the circumferential plane at the place of prominent cover rim
(Fig. 1 C), the deformation that can also be tilted；After elastic element 31 and non-elastic member 33 are detached from, 31 recoveries deformed upon are as former state
So as to beat cup body structure, so as to make a sound.In such a configuration, in order to allow non-elastic member 33 can smoothly and elasticity
The rear-face contact of element 31, because when cover cap is closed to the opening of cup, elastic element 31 is substantially at together with cover rim 30
One circumferential plane plus allowing elastic element 31 that can be contacted by separating with the elastic element back side 36, is setting non-resilient member
When part 33, non-elastic member is allowed to be tilted slightly towards the position of cup body, when cover cap is closed to suitable position, non-elastic member
33 top is contacted by the opening of partition (entering from opening) with the back side 36 of elastic element 31, so as to allow elastic element 31
Sounding deformation.
Using a part for the cover rim of cover as elastic element, relatively current traditional technology increases other knot on cover rim
Structure more easily reaches, and manufacture cost is more cheap, this is that should be processing mold technique more simple.Such as
Described in 200910225108.X and 201310582566.5 is one non-elastic member (non-elastic member of increase on cover rim
For the step gradually increased), and elastic element is set on cup body, elastic element is allowed to be deformed after non-elastic member, then
It taps cover and makes a sound, this just needs to set non-elastic member in cover, and general non-elastic member and cover rim are all same
A kind of material, this just needs cover to require the material for comparing hard or cover rim requirement thicker, could be with respect to cup body elasticity member
Part and it is allowed to deform upon, which increase costs.In addition for operability, usually cover closes the rim of a cup of cup body to cover,
The elastic element of cup body is allowed to contact the non-elastic member on cup lid, and the shape of non-elastic member is the step gradually increased
Shape needs bigger strength to carry out, and not only needs to allow deformation of elastic components, while needs the friction of client between the two
Power, if so the people for making the strength of hand small, firmly does strong, it is not easy to the defects of operating.
And the present invention allows a part for cover to come as elastic element, elastic element is allowed to deform upon in itself in cover,
When so as to set back after deformation, tap cup body or with other inelastic deformation and make a sound, need cover
Part deforms upon, and the cover rim thickness of cover, which does not need to very thick, thin cover rim, easily to be reached, material saving, cost phase
It is more cheap for disposable product；In addition, being said from operability, the part of cover rim is as elastic element, easily in rotation
The elastic element is allowed to be easier to deform upon, such as in one end of elastic element, contacted by non-elastic member, so as to allow elastic member
Part deforms upon, and for non-elastic member once in the one end for being detached from elastic element, elastic element restores original state, and taps
Cup body makes a sound.In addition, since cover is using relatively soft material making, non-elastic material is the material of slightly hard, no
It is only at low cost, and non-elastic material easily enters the inner surface of elastic element by notch, with being mutually shifted for position,
So as to be applied to the outside power of elastic element, so as to generate deformation.
In other embodiments, opposite second non-elastic member is set on exposed one end of elastic element
(protrusion or bulge-structure of hard) is so that it is convenient to allow non-elastic member and resilient element contacts on cup body, so as to more have
Conducive to the deformation of elastic element.Such as Fig. 2A -2D are illustrated, with Figure 1A -1D difference lies in exposed in elastic element 31
One end on outer surface include second non-elastic member 41, which can be in elastic member
One end of part 31 thickens naturally, and the increase of thickness is so as to the circumferential plane protrusion of opposite cover rim, in this way, the non-ballistic on cup body
Property element 33 (cannot just be allowed non-elastic member 33 such as the location and shape setting that needs to be additionally carried out as shown in Figure 1A -1D
Top slopes inwardly), but can be directly co-located with the plane of cover rim, but the element 41 for protrusion of getting along well is in same
One plane, in this way, when non-resilient process elastic element, due to the setting of the structure 41 of protrusion, 33 He of non-elastic member
Bulge-structure 41 contacts, and the face so as to allow raised street stock 41 is contacted with non-elastic member 33, because of the hard structure 41 of protrusion
Positioned at one end of elastic element 31, in this way, it is easier to allow elastic element that the deformation such as outside protrusion, tilting occur, with the two
Position be moved to subsequent disengaging, the element 31 of sounding deformation returns to the original form to tap third element (such as cup
Body is in itself) and make a sound.Structure in the present embodiment compared with the structure of examples of implementation Fig. 1, does not need to be more
Shape and the position to design non-elastic member are designed, but only that bulge-structure can be with non-resilient member on elastic element 31
Part contacts, and this contact can allow non-elastic member to give bulge-structure one outside power, it is possible to allow elastic original paper sounding to
Outer deformation (Fig. 2 C).Give bulge-structure outside power as to how contacting, the tip contact that can allow non-elastic member is raised
Element 41 or the form contact projection element (41) of lateral section.Here so-called protruding component is a relative harder
For material or relative resilient element, it is not easy to elastic deformation occurs, certainly, if as elastic element 31, but ruler
Very little difference, thickness is different, such as is thickened in the place of 1/10 outer surface of one end of elastic element 31, it will be able to reach such
Effect.
In another mode, in other embodiments, a phase is set on exposed one end of elastic element
To non-elastic member (protrusion of hard) so that it is convenient to allow non-elastic member and resilient element contacts on cup body, so as to more have
Conducive to the deformation of elastic element.Such as Fig. 3 A-3D are illustrated, with Fig. 2A -2D difference lies in exposed in elastic element 31
Inner surface on one end includes second non-elastic member 42 or the element of protrusion, which can
Being thickened naturally in one end inner surface of elastic element 31, the increase of thickness so as to the circumference inner plane protrusion of opposite cover rim,
In this way, the non-elastic member 33 on cup body cannot just need to be additionally carried out location and shape as shown in Fig. 2A -2D
Setting, but can be directly co-located with the inner plane of cover rim, but the element 42 with protrusion is not in same plane,
In this way, when it is non-resilient by elastic element when, due to protrusion structure 42 setting, non-elastic member 33 and protrusion tie
Structure 42 contacts, and the face so as to allow 42 is contacted with non-elastic member 33, because the hard structure 42 of protrusion is located at elastic element 31
One end, in this way, it is easier to allow elastic element that the deformation such as outside protrusion, tilting occur, with the two position be moved to
After be detached from, the element 31 of sounding deformation returns to the original form so as to tap third element (such as cup body is in itself) and sends out sound
Sound.Structure in the present embodiment compared with the structure of examples of implementation Fig. 1, does not need to more design to design non-ballistic
The shape of property element and position, but only that the bulge-structure of 31 upper inner surface of elastic element can connect with non-elastic member
It touches, this contact can allow non-elastic member to give bulge-structure one outside power, it is possible to make elastic original paper sounding outside
Deformation (Fig. 3 C).It gives bulge-structure outside power as to how contacting, can allow the tip contact protruding component of non-elastic member
42 or the form contact projection element (42) of lateral section.Here material of the so-called protruding component for a relative harder,
Or for relative resilient element, it is not easy to elastic deformation occurs, certainly, if as elastic element 31, but size is not
Together, thickness is different, such as is thickened in the place of 1/10 outer surface of one end of elastic element 31, it will be able to reach such effect
Fruit.More preferably, one end on non-elastic member 33 sets a protrusion 43, the bulge-structure 43 and elastic element 31
The bulge-structure 42 of inner surface contact, so as to be applied to 42 1 outside power of bulge-structure, so as to make elastic element outside
It deforms upon, after strength disappears, the rebound of elastic element 31 can encounter cup body, so as to make a sound.Non-elastic member 33 it is convex
Playing structure 42 can be as the material of non-elastic member 33 or different.This can according to suitable material into
Row is provided and selected.
In an other specific embodiment, the present invention provides a cup body, as shown in figure 4, including a collection
The cavity of fluid sample, the cavity are surrounded by side wall 101 and bottom 102, and the cavity of collection has opening 100, and opening has
Cup edge 104 has the screw-internal thread fit of screw thread, the screw thread and cover in cup edge, so as to cover the opening for closing collecting chamber.In collecting chamber
Screw thread under tool there are one cup edge 105, which is circular protrusion structure, sets non-elastic member 200 on this structure.
The present invention provides a cover 50, and including cover rim 500, an elastic element 502, the bullet are set on cover rim 500
Property element be cover a part, while elastic element 502 and cover other parts have partition, so as to as elastic element,
Such as shown in Figures 5 and 6.The elastic element and the other parts of cover rim have partition or notch 503,504, which can
Think 1-2 millimeters of gap, 1 millimeter, 2 millimeters, 3 millimeters, 4 millimeters, 5 millimeters can.Meanwhile the one of elastic element
End setting protruding component 505, which is located at the inner surface of elastic element, can be trapezoidal shape, naturally it is also possible to be
Other shapes.The inner surface 506 of the bulge-structure 505 to cover is raised, as shown in Figure 7.
When cover cap is closed to the opening of collecting chamber, the external screw thread cooperation of internal thread and collecting chamber in cover is allowed,
Lid conjunction is carried out by relative rotation, with the progress of rotation, non-elastic member and elastic element are moved closer to and contacted (as schemed
8A), after non-elastic member 200 is contacted with the bulge-structure 500 of elastic element inner surface, due to depositing in mutual effect
Easily occur outside strength in, elastic element, under the action of equivalent power, elastic element easily deforms upon, such as Fig. 8 B.When
Mutually not after contact, the power of interaction disappears, and elastic element needs return to the original form, so as to beat cup body, specifically
The cup edge or external screw thread on cup body can be beaten, so as to sounding sound, such as Fig. 8 C.
In addition, on theory structure as shown in Figs. 1-3, can also properly apply in specific product, such as non-
Elastic element is located on cup body as shown in Figure 4, and elastic element and other structures are located in the cover as shown in Fig. 5.This is
Those of ordinary skill in the art can be easy to implement by reading the present invention.
Detection method
The present invention provides a kind of method for detecting analyte in sample, including, a kind of detection device is provided, including：
One collecting chamber, the collecting chamber include an opening for being used for collecting liquid sample, and one is used for being divided in test liquid samples
It analyses the testing element of object and one is used for covering the cover for closing collecting chamber opening；Lid lid is closed in the opening of collecting chamber, allowing inspection
Whether the suggestion device prompting cover surveyed on device covers conjunction to designated position.In a mode, suggestion device passes through hair
Go out sound to be prompted.In another mode, once hearing that suggestion device sends out prompting, stop lid closing lid body to collecting chamber
Opening on.In a specific mode, cover seals the opening of collecting chamber by way of rotation, once hear prompting
Device sends out prompting, cover of stopping rotating.In addition, in a mode, once hearing that suggestion device sends out prompting, start to calculate
The time waited for required for testing result on read test element.In another mode, carried once hearing that suggestion device is sent out
Show, start to calculate the time waited for required for testing result on read test element, be simultaneously stopped rotation cover.
Testing element
Testing element can select the test strip of lateral flow, it can detect a variety of analytes.Certainly, other are closed
Suitable testing element can also be used in the present invention.
Various testing elements can be grouped together and apply in the present invention.A kind of form is Test paper.For dividing
The Test paper of analyte (such as drugs or show the metabolin of physical condition) in analysis sample can be various forms, such as exempt from
Epidemic disease measures or the form of chemical analysis.The analytical model of non-competing method or competition law may be used in Test paper.Test paper packet
The water-absorbent material that there is sample application zone containing one, reagent area and test section.Sample-adding passes through capillarity originally to sample application zone
Flow to reagent area.In reagent area, if there is analyte, sample is combined with reagent.Then sample continues to flow to detection zone.
Other reagents, such as molecule with the Non-specific combination of analyte are fixed on detection zone.These reagents and being divided in sample
Analysis object (if present) reacts and analyte is incorporated in the area or is combined with some reagent of reagent area.For showing
Show that the marker of detection signal exists and reagent area or the mark zone detached.
Typical non-competing method analytical model is if containing analyte in sample, and signal will generate, if do not wrapped
Containing analyte, signal is not just generated.In competition law, if analyte is not present in sample, signal generates, if deposited
In analyte, then signal is not generated.
Testing element is Test paper, can select water suction or the material not absorbed water.Test paper may include multiple material
It is transmitted for liquid sample.The material of one of which Test paper can cover on another material, as filter paper is covered in nitric acid
On cellulose membrane.One area of Test paper can select one or more materials, and one kind that another area selects other different
Or multiple material.Test paper can be attached on certain support or hard surface and be affectedly bashful the strong of Test paper for improving
Degree.
Analyte is detected by signal generating system, such as utilizes one with this analyte generation specific reaction
Kind or a variety of enzymes, using such as aforementioned method being fixed on specific combinating substance on Test paper, one or more signals are sent out
The composition of raw system is fixed on the analyte detection zone of Test paper.Generate signal substance can in sample application zone, reagent area,
Or on detection zone or entire Test paper, which can be full of on one or more materials of Test paper.Signal will be contained
The solution of object is added to the surface of test paper or one or more materials of test paper is immersed in the solution of the object containing signal.Contain addition
The test paper drying of signal object solution.
Each area of Test paper can arrange in the following manner：Sample application zone, reagent area, detection zone, control zone determine sample
This whether adulterated area, liquid sample uptake zone.Control zone is located at after detection zone.All areas can be arranged at only with a kind of
On one test paper of material.It may also be not same district and use different materials.Each area can directly and liquid sample contact or not
Direction arrangement of the same area according to liquid sample flowing, the end in each area is connected and overlapped with the front end in another area.Used
Material can be the preferable material of water imbibition such as filter paper, glass or nitrocellulose filter etc..Test paper can also use it
His form.
The type of sample
Any kind of sample can enough the device of the invention tested, including body fluid (for example, urine and other bodies
Liquid and clinical sample).Liquid sample may originate from solid or semisolid sample, including excrement, biological tissue and food
Sample.These solids and semisolid sample can be transformed into liquid sample, such as in one kind by any suitable method
Mixed in appropriate liquid, stamp it is broken, macerate, be incubated, dissolving either digest solid sample (for example, water phosphate buffer or
Other buffer solutions)." biological sample " including being originated from animal living, plant and the sample of food, also including urine, saliva, blood
With blood constituent, cerebrospinal fluid, vaginal swab, sperm, excrement, sweat, secretion, tissue, organ, tumour, tissue and organ
It is the conditioned media of culture, cell culture and there, either people or animal.Food sample includes finished food
Object ingredient and last product, meat, cheese, wine, milk and drinking water.Plant sample include from any plant, plant tissue,
The sample of the conditioned media of plant cell cultures and there." environmental samples " are that those are originated from the sample of environment (for example, lake water
The sample of sample or other water bodys, sewage sample, soil sample, underground water sample, Seawater Samples, the sample of runoff water).
Sewage and relevant waste can also be included in environmental samples.
The type of analyte
Any analyte can be analyzed with the present invention.The example packet of the analyte of stable detection of the present invention can be used
Include (but not only including) human chorionic gonadotrophin (hCG), lutropin (LH), ovarian stimulation element (FSH), hepatitis
The drug of viral (HCV), hepatitis B (HBV), hepatitis B surface antigen, AIDS virus and any abuse.Analyte can
It is detected, such as urine in any liquid or liquefaction sample, saliva, saliva, blood, blood plasma or serum.It is other
The example of analyte also has flesh ammonia acid anhydride acid, bilirubin, nitrite, protein (nonspecific), blood, leucocyte, blood
Sugar, heavy metal and toxin, bacterial component (for example, the special protein and sugar of certain types of bacterium, such as Escherichia coli
0157:H7, staphylococcus aureus, salmonella, C.perfringens, campylobacter, listeria monocytogenes, enteritis arc
Bacterium or wax bacillus).The analyte of any other suitable lateral flow test format can be detected with the present apparatus.
Analyte, which can also be, to be infectious substance or can prompt the substance of infection period.Analyte can be drug (such as drug abuse
Object), hormone, albumen, nucleic acid molecules, pathogen." drug abuse " (DOA) refers to that non-medical destination (is usually risen using drug
Benumb the effect of nerve).Abusing these drugs can cause body ＆ mind to be damaged, generate dependence, it is addicted and/or
It is dead.The example of drug abuse includes cocaine；Amphetamine is (for example, black beauty, white amphetamine tablet, dextrorotation peace are non-
He is life, dexie, Beans)；Crystal methamphetamine (crank, meth, crystal, speed)；Bar ratio
Appropriate hydrochlorate is (such asRoche Pharmaceuticals, Nutley, New Jersey)；Sedative (i.e. sleep auxiliary
Drug)；Lysergic acid diethylamide (LSD)；Inhibitor (downers, goofballs, barbs, blue devils, yellow
Jackets, methaqualone)；The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin)；Phencyclidine
(PCP)；Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc..)；Opiate (i.e. morphine, opium, codeine, Hai Luo
Cause, hydroxyl dihydrocodeinone).Can be used for belonging to medical usage using the test strip but the easily inspection of overdose
It surveys, such as tricyclic antidepressant (imipramine or the like) and Paracetamol.
Claims (12)
1. a kind of device for detecting analyte in sample, which is characterized in that the device includes：Receive the collection of liquid sample
Chamber, the collecting chamber include an opening；For the testing element of analyte in test liquid samples；It is opened with for covering conjunction collecting chamber
The cover of mouth；Wherein further include whether a prompting cover covers the suggestion device closed to designated position on collecting chamber on device,
In, the suggestion device is prompted by making a sound, wherein, the suggestion device includes a non-elastic member and bullet
Property element, wherein the non-elastic member is located on collecting chamber, elastic element in cover, wherein, the elastic element
A part for cover.
2. the apparatus according to claim 1, which is characterized in that have between the elastic element and the other parts of cover
Spaced gap.
3. the apparatus of claim 2, which is characterized in that the elastic element is one of the cover rim of the cover
Point.
4. device according to claim 3, which is characterized in that the elastic element is rectangle structure, described rectangular
The other parts of two sides of the length of shape structure and the cover rim of cover have the gap, wherein short a line connects with cover rim
It connects, short another side is exposed.
5. device according to claim 4, which is characterized in that in the interior table of the elastic element on described exposed short one side
Face has bulge-structure.
6. device according to claim 4, which is characterized in that described exposed short one side elastic element it is outer
Surface has bulge-structure.
7. according to the device described in one of claim 6 or 5, which is characterized in that in the bulge-structure and elastic element
Material is identical, and the thickness of the bulge-structure is more than the thickness of elastic element.
8. device according to claim 5 or 6, which is characterized in that the elastic amount of touching of the bulge-structure is more than
The elastic feel quantity of elastic element.
9. device according to claim 5, which is characterized in that the outer wall of the collecting chamber is provided with described non-resilient
During element, the external screw thread of the collecting chamber and the internal thread of cover are closed by swivelling cover, non-elastic member and elasticity member
The bulge-structure contact of the inner surface of part, so as to which elastic element be allowed to deform upon.
10. device according to claim 6, which is characterized in that the outer wall of the collecting chamber is provided with the non-ballistic
Property element, during the external screw thread of the collecting chamber and the internal thread of cover are closed by swivelling cover, non-elastic member and elasticity
Bulge-structure contact on the outer surface of element, so as to which elastic element be allowed to deform upon.
11. the apparatus according to claim 1, which is characterized in that the collecting chamber has external screw thread, and cover has therewith
The internal thread of cooperation, wherein not having internal thread on the elastic element being located in cover.
12. according to the device described in one of claim 9 or 10, which is characterized in that the direction of the deformation is far from lid
Along all planes at place.
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| CN201711276092.6A CN108254494B (en) | 2017-12-06 | 2017-12-06 | Device for detecting analyte in sample |
| US16/209,293 US11097266B2 (en) | 2017-12-06 | 2018-12-04 | Apparatus for detecting the presence or absence of an analyte in samples |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102072950A (en) * | 2009-11-23 | 2011-05-25 | 艾博生物医药(杭州)有限公司 | Device for detecting analyzed substance in sample |
| WO2012146116A1 (en) * | 2011-04-29 | 2012-11-01 | Abon Biohparm (Hangzhou) Co., Ltd | An assay device for testing an analyte in samples |
| CN204882557U (en) * | 2015-06-09 | 2015-12-16 | 杭州迪图科技有限公司 | Detect fluid sample median by device of analyte |
| US20170001191A1 (en) * | 2014-01-20 | 2017-01-05 | Abogen, Inc. | Devices, solutions and methods for sample collection |
| US20190168208A1 (en) * | 2017-12-06 | 2019-06-06 | Hangzhou Biotest Biotech Co., Ltd. | Apparatus for Detecting the Presence or Absence of An Analyte in Samples |
| CN211856500U (en) * | 2017-12-06 | 2020-11-03 | 张科峰 | Device for detecting analyte in sample |
-
2017
- 2017-12-06 CN CN201711276092.6A patent/CN108254494B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102072950A (en) * | 2009-11-23 | 2011-05-25 | 艾博生物医药(杭州)有限公司 | Device for detecting analyzed substance in sample |
| US20130004940A1 (en) * | 2009-11-23 | 2013-01-03 | Haipeng Hu | Device for Detecting Analyte in Sample |
| WO2012146116A1 (en) * | 2011-04-29 | 2012-11-01 | Abon Biohparm (Hangzhou) Co., Ltd | An assay device for testing an analyte in samples |
| CN105181946A (en) * | 2011-04-29 | 2015-12-23 | 艾博生物医药(杭州)有限公司 | Device capable of indicating analyte in detection sample by making sounds |
| US20170001191A1 (en) * | 2014-01-20 | 2017-01-05 | Abogen, Inc. | Devices, solutions and methods for sample collection |
| CN204882557U (en) * | 2015-06-09 | 2015-12-16 | 杭州迪图科技有限公司 | Detect fluid sample median by device of analyte |
| US20190168208A1 (en) * | 2017-12-06 | 2019-06-06 | Hangzhou Biotest Biotech Co., Ltd. | Apparatus for Detecting the Presence or Absence of An Analyte in Samples |
| CN211856500U (en) * | 2017-12-06 | 2020-11-03 | 张科峰 | Device for detecting analyte in sample |
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