CN108254494B

CN108254494B - Device for detecting analyte in sample

Info

Publication number: CN108254494B
Application number: CN201711276092.6A
Authority: CN
Inventors: 张科峰
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-12-06
Filing date: 2017-12-06
Publication date: 2024-04-05
Anticipated expiration: 2037-12-06
Also published as: CN108254494A

Abstract

The present invention provides a device for detecting an analyte in a sample, the device comprising: a collection chamber for receiving a liquid sample, the collection chamber including an opening; a test element for testing an analyte in a liquid sample; and a cover for covering the collection chamber opening; the device also comprises a prompting device for prompting whether the cover body is covered on the designated position on the collecting cavity, wherein the prompting device prompts by sending out sound, the prompting device comprises a non-elastic element and an elastic element, the non-elastic element is positioned on the collecting cavity, the elastic element is positioned on the cover body, and the elastic element is a part of the cover body. The device is used for detection, and is simple to operate.

Description

Device for detecting analyte in sample

Technical Field

The present invention relates to a detection device for detecting the presence or absence of an analyte in a liquid sample, and in particular to a detection device that prompts the start of the detection device or the completion of capping by generating an audible cue.

Background

In the field of healthcare, detection of bodily fluids is a common activity. Factories, government agencies, sports teams, and other organizations have increasingly utilized diagnostic tests to maintain workplace safety and ensure compliance with laws, regulations, and regulations.

It is a very common method to collect a liquid sample, such as urine, with a detection device and determine the presence of a specific analyte (e.g., a drug and/or a metabolite thereof, or a disease-related marker). Such test devices typically require that the sample be collected in a sample container, and the relevant technician inserts a test strip and submerges a portion of the strip in the sample, and then removes the strip read. The technician may contact the sample and may compromise health or contaminate the sample. To avoid this risk, it is necessary to apply a closure cap to the sample collection container. Currently, there are many sealing devices, such as those disclosed in U.S. Pat. No. 4, 4,976,923,US 5,429,804, and U.S. Pat. No. 3, 6,726,879. These devices are designed to secure a test strip to the cover of the test device. When the device is used, the container is turned over or inclined to enable the sample to infiltrate the detection test strip for detection. U.S. patent application publication No. 2003/0027359A1, published 2/6/2003, discloses a test urine cup. The test urine cup still requires a push rod to push the plunger to move after the lid is closed to the opening of the cup to allow the fluid sample to flow out of the cup cavity and wet the test element. Chinese published patent application 200510113977.5 discloses a test urine cup. The test urine cup initiates the flow of liquid from the collection chamber to the test chamber after the lid is closed to the opening of the cup, thereby initiating the start of the test. In another chinese application published patent application 200480033286.8 a test urine cup is also disclosed. The initiation of the test is initiated after the urine cup is inspected and the lid is closed to the opening of the cup.

Recently, such detection devices have been increasingly adopted by ordinary households or non-professional institutions. Since these detection evaluations are designed specifically for non-professionals, these detection devices need to make the operation process simple and to ensure the accuracy of the detection results. At present, devices have appeared on the market which start by generating audible prompts detecting means, or the cover has been closed in a preset position, such testing means having been described in particular in chinese patent application nos. 20110115654.5, 20091025108. X and 201310582566.5. These means may be operated by the operator himself, who stops rotating by means of a mechanical structure when the lid is closed to the opening of the cup, thus making it easier to achieve the detection and increasing the confidence of the operator and avoiding additional problems.

In chinese patent 201110115654.5, in this application, it is disclosed that, after the elastic sheet is deformed, in the process of returning to the original shape, the vibration is vibrated to make a sound, and the vibration is self-damped. In 20090225108. X and 201310582566.5, it is described that the elastic member is deformed by passing through the inelastic member, and then the cover is knocked to make a sound during the process of returning to the original state. Although the above can make sound, the structure is required to be additionally arranged, the operation is more labor-consuming, the production difficulty is high, and the defects of high die cost and the like exist in the plastic disposable products.

Therefore, a detection device which is simple to operate and accurate and reliable in detection result is required by the current society. The invention provides a detection device meeting the requirement, and the detection device is improved from the traditional detection device.

Disclosure of Invention

The invention provides a detection device which is simple to operate. In particular to a urine cup for detection, which is simple to operate. After the lid of the urine cup is covered on the opening of the cup, a prompting device is also included on the detection urine cup, and the prompting device prompts whether the lid is covered on the appointed position. On the one hand, when the lid is closed over the opening of the cup, different operators, especially those not skilled in the art, may cause the tightness of the lid to the opening of the cup to be different, which may result in some lids not sealing the opening of the cup well and some detecting the possibility of leakage from the urine cup.

The present invention provides a means of prompting on the detection means that when the lid is closed to a designated location on the collection chamber (which location can be considered to be sufficient for the lid to seal the opening of the collection chamber), the means of prompting that the lid has sealed the opening of the collection chamber and that the operator no longer needs to close the lid. This allows the opening of each device to be completely sealed without fear of leakage. In some devices, on the other hand, the liquid sample in the collection chamber contacts the test element for detection once the cap is closed over the opening of the collection chamber. In conventional test cups, it is generally necessary to begin counting the time until the test results are read from the test area on the test element. When different operators operate, the calculation time does not have consistent and unified standards from the specific time, and the same device can cause different detection results for different operators. The present invention provides a detection device that emits a warning message, such as a sound, that tells an operator to begin counting the time to wait for reading test results on a test element when the lid is closed to a designated location on the collection chamber.

In one aspect, the invention provides a device for detecting the presence of an analyte in a sample, comprising: a collection chamber comprising an opening for collecting a liquid sample; and a cover for covering the collection chamber opening; the device also comprises a prompting device for prompting whether the cover body is covered at the appointed position.

In some preferred forms, the prompting device prompts that the cover has sealed the opening of the collection chamber when the cover is closed to the prescribed position. Alternatively, the device may further comprise a test element capable of contacting the liquid sample to perform a test or assay of the analyte in the liquid sample, and the prompting means prompts the start of calculation of the waiting time for reading the detection result on the test element when the cover is closed to the designated position.

In some preferred forms, the prompting means prompts by emitting a sound. In some embodiments, the prompting device includes elements that can make a sound by collision after elastic deformation. Specifically, the prompting device comprises two elements, and after the first element and the second element are contacted with each other, one of the two elements elastically deforms and then rebounds to collide with the other third element to make a sound so as to prompt. In a specific manner, the prompting device includes a first element that is an elastic element and a second element that is a non-elastic element, when the elastic element passes through the non-elastic element, the elastic element is pressed by the non-elastic element to change to generate elastic deformation, and when the pressed force disappears, the elastic element rebounds again to generate sound, and the rebounds can collide with or strike another third element, or the elastic element and the non-elastic element collide with each other to generate sound. The third element may be a separate element or may be an element provided on the cup or the lid, or may be a structure constituting a part of the cup or the lid.

More preferably, the elastic element may be located on an outer surface of the cover rim of the cover body; the non-elastic element may also be located on the outer wall surface of the cup opening. In a more specific embodiment, the elastic element is part of the cover rim of the cover body, and before deformation, the elastic element on the cover rim is part of the cover body but is connected with the cover body. Specifically, in order to provide the elastic member on the cover body, a portion is separated from the cover edge as the elastic member, and generally the cover edge has an internal thread structure, and the separated portion is spaced from other portions of the cover edge by 1-2 mm, or the separated portion is spaced from other portions of the cover edge on both sides and has one side connected to the cover edge. For example, the divided portion (the elastic member itself) is about one twentieth of the lid edge, or less, of a generally rectangular configuration, with the long side of the upper divided portion of the lid edge being separated from the lid edge, the short side being connected to the lid body, and the other short side being exposed as the side of the lid edge of the lid body, referred to as the exposed side. Such a structure can generally be achieved by injection molding disposable molds.

Preferably, the cup body is provided with a non-elastic element which is generally parallel to the longitudinal direction of the cup body, but is slightly inclined to the cup body, so that when the cup opening is covered by the cover body, one protruding end or the exposed end of the non-elastic element is contacted with the inner side or the inner surface of the exposed edge of the elastic element on the cover body, and when the cup opening is covered by the cover body in a rotating manner, the non-elastic element continuously contacts with the inner side of the exposed edge of the elastic element on the cover body, and the elastic element on the cover body is subjected to outward pushing force and naturally protrudes outwards from the cover body of the cover body or is called tilting, the elastic element is generally rectangular, long two sides are separated from the cover edge, so that the cover is tilted towards the surface of the circumference where the cover is located, and after the non-elastic element is separated from the elastic element (along with the change of the relative position), the elastic element needs to return to the original position, so that the cup body is knocked to make a sound.

In some preferred embodiments, the outer surface or/and the inner surface of the exposed edge of the elastic element on the lid edge includes an inelastic element, or referred to as a raised structure, which may be located on the exposed edge of the elastic element or a portion of the exposed edge of the elastic element may be made of an inelastic material, so that the inelastic element on the cup contacts the inelastic portion of the elastic element to make it easier for the elastic element to denature.

In a preferred form, the exposed edge of the resilient member includes a non-resilient member thereon which contacts the non-resilient member on the cup to facilitate the resilient member to bulge or tilt up along the surface of the lid to deform. Preferably, the underside of the non-elastic element on the elastic element is in contact with the top end of the non-elastic element on the cup, thereby allowing the elastic element to more easily bulge or tilt toward the face along which the lid is located.

In addition, the inelastic element and the collection chamber can move counter clockwise relative to the cover; elastic element and cover opposite to and collecting the chambers may also be moved synchronously clockwise. In an alternative scheme, under the interaction force of the elastic element on the cover body and the non-elastic element on the cup body, the elastic element is elastically deformed, and after the interaction force is eliminated, the elastic element and the non-collision prompt sound.

In other embodiments, the inelastic element is composed of ABS material; the elastic element is composed of PP material. Optionally, after the resilient member passes over the non-resilient member and strikes the cup, the resilient member is prevented from moving clockwise relative to the cup by the non-resilient member. In another alternative, the resilient member is capable of moving clockwise relative to the cover after the resilient member passes over the non-resilient member and strikes the cup. Optionally, the mode that the lid closes the collection chamber opening is that the lid seals the opening of collection chamber through rotatory mode, and the opening includes the external screw thread with lid complex, and the lid includes the internal screw thread with the opening complex.

In some preferred forms, the resilient member on the rim does not have internal threads thereon that mate with the threads on the outer rim of the cup.

In another aspect, the invention provides a method of detecting an analyte in a sample, comprising providing a detection device comprising: a collection chamber comprising an opening for collecting a liquid sample and a cover for covering the collection chamber opening; the cover is covered on the opening of the collecting cavity, and a prompting device on the detecting device prompts whether the cover body is covered on the appointed position. In one embodiment, the presentation means presents by emitting a sound. In another embodiment, once the prompt is heard, the prompt means stops continuing to cover the cover over the opening of the collection chamber. In a specific embodiment, the cover seals the opening of the collection chamber by rotating, and the cover is stopped from rotating once the prompting device is heard. Furthermore, in one embodiment, the waiting time required for reading the detection result on the test element is started once the prompting device is heard to issue a prompt. In another embodiment, once the prompt is heard by the prompt device, the calculation of the waiting time required to read the test result on the test element is started, while the rotation of the cover is stopped.

The invention provides a method for detecting an analyte in a sample, comprising: providing a detection device comprising a collection chamber having an opening; a test element; and a cover rotatable relative to the collection chamber to seal the collection chamber opening, wherein the device further comprises a prompting device for prompting whether the cover is rotated to a specified position; the cover body is rotated until the prompting device sends out a prompt.

In some preferred forms, the rotation is stopped after the prompting device issues a prompt. Optionally, after the prompting device issues the prompt, the calculation of the waiting time for reading the detection result on the test element is started. In a specific embodiment, the prompting device prompts by emitting a sound. More preferably, the prompting device comprises a non-elastic element protruding from the outer surface of the collecting cavity and an elastic element on the cover edge, wherein the elastic element is a part of the cover edge of the cover body, and the elastic element deforms after pressing the exposed edge of the non-elastic element during the rotation of the cover body, and when the non-elastic element is separated from the elastic element, the non-elastic element knocks the cup body to generate a sound. Most preferably, the non-elastic element comprises a raised structure having a certain rigidity, and the exposed edge of the elastic element, which is part of the cover body, is in contact with the raised structure of the non-elastic element, thereby tilting outwards.

Advantageous effects

The device and the method of the invention lead the operation of the detection device to be simpler, are suitable for non-professional people to use, and simultaneously provide more accurate detection results. In addition, the device of the invention has low cost and easier operation, and can generate crisp sound without great strength.

Drawings

Fig. 1A-1D are schematic structural diagrams of sound production in an embodiment of the present invention.

Fig. 2A-2D are schematic structural diagrams of sounding principles in another embodiment of the present invention.

Fig. 3A-3D are schematic structural diagrams of sounding principles in another embodiment of the present invention.

FIG. 4 is a schematic perspective view of a cup according to an embodiment of the present invention, wherein the inelastic element is located on the cup.

Fig. 5 is a schematic perspective view of a cover according to an embodiment of the present invention, in which an elastic element is located on the cover and is a part of the rim.

Fig. 6 is a drawing of the cover rim of the cover with the elastic element in one embodiment of the invention (cover in fig. 5).

Fig. 7 is a schematic perspective view of a cover surface of a cover body with an elastic element according to an embodiment of the present invention (the cover body in fig. 5).

FIGS. 8A-8C are schematic structural views of a process of closing the lid onto the cup, the lid of FIG. 8A being closed onto the cup; FIG. 8B is a view of the resilient member being forced to tilt toward the cover along the periphery; fig. 8C is a schematic diagram of the positional relationship after the inelastic element and the elastic element are disengaged.

Detailed Description

The structure to which the present invention relates or these terms of technology are further described below.

Detection of

Detection indicates the assay or testing for the presence of a substance or material, such as, but not limited to, a chemical substance, an organic compound, an inorganic compound, a metabolic product, a drug or drug metabolite, an organic tissue or a metabolite of an organic tissue, a nucleic acid, a protein or a polymer. In addition, the detection indicates the amount of the test substance or material. Further, assays also refer to immunoassays, chemical assays, enzymatic assays, and the like.

Detection device

In one embodiment, the test device comprises a collection chamber 10 for collecting and storing a liquid sample, the collection chamber being defined by a sidewall 101 and a bottom 102, and comprising an opening 100 for introducing the liquid sample. The words "a" or "an" in the specification, including the abstract and the claims, should be understood to mean at least one, or include one in number, and not merely "unique" or "only one" means. For example, the detection means comprises a prompting means, it is obvious that the inclusion of 2 or more prompting means on the detection means shall also fall within the scope of the claims of the present invention and not be excluded. The test device may further comprise a test chamber 207 containing a test element, wherein the liquid sample in the collection chamber may freely or controllably contact the test element in the test chamber; the chemical reagent on the test element can test for the presence or amount of analyte present in the liquid sample. The detection device may further comprise a cover 30 for covering the opening 100 of the collection chamber. In a specific embodiment, the detection means comprise a prompting means which can prompt whether the cover is covered in a specified position or not, and in more detail, whether the cover is covered in a specified position on the collection chamber or not. In one aspect of the present invention, when the cover is closed to a designated position on the collection chamber, the prompting device can prompt that the cover body seals the opening of the collecting cavity. On the other hand, when the cover is closed to a designated position on the collection chamber, the prompting device may prompt the time to begin waiting for the test results on the test element to be read. There are a variety of ways in which the cap may be closed onto the collection chamber, for example in the form of a screw thread. For example, the opening of the collecting cavity comprises external threads, and the cover body comprises internal threads matched with the external threads; after the cover is closed onto the collection chamber, the opening is sealed by relative rotation. Alternatively, the cover may be in the form of a piston, and the opening may be sealed by inserting the cover into the opening.

The prompting device of the invention can also be applied to other detection devices, in particular to devices which comprise a cover body and are used for sealing the opening of the collecting cavity; such other similar devices are disclosed in the already published U.S. patent, US 7,270,959; US 7,300,633; US 7,560,272; as described in detail in US 7,438, 852,US 4,976,923,US 5,429,804, US 6,726,879, etc., the disclosed indicator device may be incorporated into each of the embodiments of the detection devices disclosed in the above patents as one of the embodiments of the present invention.

Prompting device

In one embodiment, the prompting device may be located on the detecting device, and the prompting device prompts by emitting a sound. Such sound may be "snap", "pop", "dong", "dingpin", "snap" or any other suitable sound.

The prompting device generally comprises an element, one being an elastic element and one being a non-elastic element. The terms "elastic element" and "inelastic element" as used herein are intended to be relative terms. In this arrangement, the elastic member generally has a smaller elastic modulus than the inelastic member. For example, plastic is selected as the elastic element, and metal such as iron, steel or lead is selected as the material of the inelastic element, so that the elastic touch quantity of the elastic element is smaller than that of the inelastic element under the action of the mutual force of the plastic and the inelastic element, the elastic element is relatively easier to change in shape under the condition that the mutual force of the elastic element and the inelastic element is the same, and when the applied force is instantaneously eliminated, the elastic element needs to be restored, so that the third element (or the cup body) is knocked or the second element is knocked to generate vibration to generate sound. The forces to which the elastically deformable elements are subjected generally need to be less than the elastic limit inherent in the elements so that they can return themselves to their original shape when the external force is removed. Alternatively, both the elastic and inelastic elements are of plastic material.

In some preferred forms, such as the structures shown in figures 1A-1D, the elastic element 30 is located on the cover, as part of the cover, in particular, it is part of the lid rim 30 which includes internal threads that mate with external threads of the cup to rotationally seal the opening of the cup. The resilient member 30 is generally rectangular in shape with the long sides being spaced from the other longitudinal portions 32,35 of the rim 30 such that one short side is connected to the rim and the other short side is suspended and serves as an exposed side, also as a rim of the rim. When the inelastic element 33 on the cup passes the elastic element, the elastic element deforms from inside to outside as the relative position moves due to the contact between the inelastic element and the face (inner face) 36 of the elastic element, which is close to the cup (fig. 1B), and the elastic element is subjected to the outward force of the principle cover along the plane, so as to protrude out of the circumferential plane (fig. 1C) along which the cover lies, and also can deform by tilting; when the elastic member 31 and the inelastic member 33 are disengaged, the deformed member 31 is restored to be the original shape to knock the cup structure, thereby making a sound. In such a configuration, in order to allow the non-elastic element 33 to smoothly contact the back surface of the elastic element 31, since the elastic element 31 is substantially in the same circumferential plane as the lid edge 30 when the lid is closed to the opening of the cup, the elastic element 31 can be brought into contact with the elastic element back surface 36 by the partition, and the non-elastic element 33 is slightly inclined to the position of the cup when the non-elastic element 33 is provided, and when the lid is closed to a proper position, the tip of the non-elastic element 33 is brought into contact with the back surface 36 of the elastic element 31 through the opening of the partition (into from the opening), thereby allowing the elastic element 31 to be deformed by sound.

A part of the cover edge of the cover body is used as an elastic element, and compared with the prior art, the structure of adding another structure on the cover edge is easier to achieve, the manufacturing cost is lower, and the process of processing the die is simpler. For example, in 20091025108. X and 201310582566.5, a non-elastic element is added to the lid (the non-elastic element is a step that increases gradually), and an elastic element is provided on the cup body, so that the elastic element deforms after passing through the non-elastic element, and then the lid body is knocked to make a sound. In addition, in terms of operability, it is common that the lid body covers the cup mouth of the cup body, the elastic element of the cup body is made to contact the inelastic element on the cup lid, and the inelastic element is shaped in a gradually increasing step shape, and needs a relatively large force, so that not only the elastic element needs to be deformed, but also a friction force between the elastic element and the client is required, so that if the force of the hand is small, the force is dry and strong, and the operation is not easy.

In the invention, a part of the cover body is used as the elastic element, and the elastic element is deformed, so that when the cup body is knocked or the cup body and other inelastic deformation are carried out to generate sound after the deformation, the part of the cover body which is needed to be deformed is deformed, the thickness of the cover edge of the cover body is not needed to be very thick, the thin cover edge can be easily achieved, the material is saved, and the cost is lower than that of a disposable article; in addition, from the operational aspect, the cover edge part is used as an elastic element, so that the elastic element is easy to deform during rotation, for example, one end of the elastic element is contacted by an inelastic element, the elastic element is deformed, and once the inelastic element is positioned at one end of the elastic element, the elastic element is restored to the original state, and the cup body is knocked to generate sound. In addition, the cover body is made of a softer material, and the inelastic material is a slightly hard material, so that the cost is low, and the inelastic material is easily entered into the inner surface of the elastic member through the gap and is deformed by the outward force applied to the elastic member as the positions are moved relative to each other.

In other embodiments, a relatively second inelastic element (rigid boss, or boss structure) is provided on the exposed end of the elastic element to facilitate contact of the inelastic element on the cup with the elastic element and thereby further facilitate deformation of the elastic element. For example, as illustrated in fig. 2A-2D, the difference from fig. 1A-1D is that the outer surface at the exposed end of the elastic element 31 includes a second inelastic element 41, which second inelastic element 41 may be naturally thickened at one end of the elastic element 31 and increased in thickness to bulge relative to the circumferential plane of the lid, so that the inelastic element 33 on the cup may not be positioned and shaped as otherwise required (with the tip of the inelastic element 33 inclined inwardly) as shown in fig. 1A-1D, but may be positioned directly in the same plane as the plane of the lid, but not in the same plane as the bulge element 41, so that when inelastic passes the elastic element, the inelastic element 33 contacts the bulge structure 41 to allow the bulge element 33 to contact the bulge element 41 because the bulge stiff structure 41 is at one end of the elastic element 31, so that the elastic element is more easily deformed outwardly to bulge, warp, tilt, etc., as the two positions move to the subsequent sounding element 31 to resume its original shape, such as a third sound-generating shape, e.g., a knocking element 31. In the structure of this embodiment, no more design is required to design the shape and position of the inelastic element than the structure of embodiment sub-fig. 1, but only the convex structure on the elastic element 31 is required to contact with the inelastic element, and this contact can make the inelastic element apply an outward force to the convex structure to make the elastic element sound and deform outward (fig. 2C). As to how the outward force is applied to the raised structures, the tips of the non-elastic elements may be brought into contact with the protruding elements 41, or in the form of a transverse cut, contacting the protruding element (41). The protruding element is here a relatively hard material or is not easily elastically deformable in relation to the elastic element, which can of course be achieved if it is the same as the elastic element 31 but of different dimensions and thickness, for example thicker at 1/10 of the outer surface of one end of the elastic element 31.

In another embodiment, a relatively inelastic member (rigid boss) is provided on the exposed end of the elastic member, which facilitates contact between the inelastic member and the elastic member on the cup, thereby further facilitating deformation of the elastic member. For example, as illustrated in fig. 3A-3D, the difference from fig. 2A-2D is that the inner surface on the exposed end of the elastic element 31 includes a second nonelastomeric element 42 or raised element, the second nonelastomeric element 42 may be naturally thickened on the inner surface of the end of the elastic element 31, the thickness being increased to be raised relative to the circumferential inner plane of the rim, such that the nonelastomeric element 33 on the cup may not be positioned and shaped as shown in fig. 2A-2D, but may be positioned directly in the same position as the inner plane of the rim, but not in the same plane as the raised element 42, such that when nonelastomeric passes over the elastic element, the nonelastomeric element 33 is in contact with the raised structure 42, thereby allowing the face of the nonelastomeric element 33 to be in contact with the raised hard structure 42 at the end of the elastic element 31, such that the outward raising, lifting, etc. of the elastic element is easier to deform, and such that the sound-producing element 31 itself is restored to the third acoustic shape, e.g. the cup itself, as the position of the two is moved to the inner plane of the rim. In the structure of this embodiment, no more design is required to design the shape and position of the inelastic element than the structure of embodiment sub-fig. 1, but only the convex structure on the upper inner surface of the elastic element 31 is required to contact with the inelastic element, and this contact can make the inelastic element apply an outward force to the convex structure to make the elastic element sound and deform outward (fig. 3C). As to how to contact the outward force to the raised structure, the tips of the inelastic elements may be brought into contact with the raised elements 42 or the raised elements (42) may be brought into contact in the form of a transverse cut. The protruding element is here a relatively hard material or is not easily elastically deformable in relation to the elastic element, which can of course be achieved if it is the same as the elastic element 31 but of different dimensions and thickness, for example thicker at 1/10 of the outer surface of one end of the elastic element 31. More preferably, a protrusion 43 is provided at one end of the non-elastic member 33, and the protrusion 43 contacts the protrusion 42 of the inner surface of the elastic member 31, so that an outward force is applied to the protrusion 42, thereby deforming the elastic member outward, and when the force is removed, the elastic member 31 rebounds to collide with the cup body, thereby emitting a sound. The protruding structures 42 of the inelastic elements 33 may be the same as or different from the inelastic elements 33. This may be arranged and selected according to the appropriate material.

In another embodiment, the invention provides a cup, as shown in fig. 4, comprising a chamber for collecting a fluid sample, the chamber being defined by a sidewall 101 and a bottom 102, the chamber having an opening 100 with a rim 104 having threads thereon that mate with internal threads of the cover to cover the opening of the chamber. Below the threads of the collection chamber there is a rim 105, which is an annular protruding structure on which the non-elastic element 200 is arranged.

The present invention provides a cover 50 comprising a cover rim 500, and a resilient member 502 provided on the cover rim 500, the resilient member being part of the cover, and the resilient member 502 being separated from other parts of the cover, thereby acting as a resilient member, as shown in fig. 5 and 6, for example. The resilient member has interruptions or notches 503,504 from the remainder of the rim, which interruptions may be 1-2 mm gaps, 1 mm, 2 mm, 3 mm, 4 mm, 5 mm. Meanwhile, a protrusion member 505 is provided at one end of the elastic member, and the protrusion member is located on the inner surface of the elastic member, and may have a trapezoid shape, but may have other shapes. The raised structure 505 projects toward the inner surface 506 of the cover as shown in fig. 7.

When the cover is covered on the opening of the collecting cavity, the internal thread in the cover is matched with the external thread of the collecting cavity, the cover is covered by relative rotation, and as the rotation is carried out, the inelastic element and the elastic element are gradually close to and contacted with each other (as shown in fig. 8A), after the inelastic element 200 is contacted with the convex structure 500 on the inner surface of the elastic element, the elastic element is easy to generate outward force due to the existence of interaction, and the elastic element is easy to generate deformation under the action of the equivalent force, as shown in fig. 8B. When the contact is not performed, the interaction force disappears, and the elastic element needs to restore to the original shape so as to strike the cup body, specifically, the cup edge or the external thread on the cup body can be struck, so that the sound can be generated, as shown in fig. 8C.

In addition, the principle structure shown in fig. 1-3 can be suitably applied to specific products, for example, the inelastic element is positioned on the cup body shown in fig. 4, and the elastic element and other structures are positioned on the cover body shown in fig. 5. This is readily achievable by one of ordinary skill in the art upon reading the present disclosure.

Detection method

The invention provides a method for detecting an analyte in a sample, comprising the steps of providing a detection device comprising: a collection chamber comprising an opening for collecting a liquid sample, a test element for testing an analyte in the liquid sample, and a cover for covering the opening of the collection chamber; the cover is covered on the opening of the collecting cavity, and a prompting device on the detecting device prompts whether the cover body is covered on the appointed position. In one embodiment, the presentation means presents by emitting a sound. In another embodiment, the closing of the lid onto the opening of the collection chamber is stopped upon hearing the prompt from the prompting device. In a specific embodiment, the cover seals the opening of the collection chamber by rotating, and the cover is stopped from rotating once the prompting device is heard. Furthermore, in one embodiment, the waiting time required for reading the detection result on the test element is started once the prompting device is heard to issue a prompt. In another embodiment, once the prompt is heard by the prompt device, the calculation of the waiting time required to read the test result on the test element is started, while the rotation of the cover is stopped.

Test element

The test element may be a lateral flow test strip that detects multiple analytes. Of course, other suitable test elements may be employed with the present invention.

Various test elements may be combined together for use in the present invention. One form is test paper. Test strips for analyzing analytes in a sample, such as drugs or metabolites indicative of a physical condition, may be in various forms, such as immunoassay or chemical analysis. The test strip can adopt an analysis mode of a non-competition method or a competition method. The test paper comprises a water absorbing material with a sample adding area, a reagent area and a test area. Sample is applied to the sample application region and flows to the reagent region by capillary action. In the reagent zone, the sample binds to the reagent if the analyte is present. The sample then continues to flow to the detection zone. Other reagents, such as molecules that specifically bind to the analyte, are immobilized in the detection zone. These reagents react with and bind the analyte (if present) in the sample to the region, or to a reagent in the reagent region. The label for displaying the detection signal is present in a separate label zone from the reagent zone.

A typical non-competitive assay format is one in which a signal is generated if the sample contains an analyte and no signal is generated if the sample does not contain an analyte. In competition methods, a signal is generated if the analyte is not present in the sample, and no signal is generated if the analyte is present.

The test element is a test paper, and can be made of water-absorbing or non-water-absorbing materials. The test strip may comprise a variety of materials for liquid sample transfer. One of the test strips may be coated with another material, such as a filter paper, on a nitrocellulose membrane. One region of the test strip may be of one or more materials and another region of the test strip of a different material or materials. The test strip may be adhered to a support or hard surface for improving the strength of the pinch test strip.

The analyte is detected by the signal generating system, e.g., using one or more enzymes that specifically react with the analyte, and the composition of the one or more signal generating systems is immobilized on the analyte detection zone of the test strip using the method of immobilizing a specific binding material on the test strip as described previously. The signal generating substance may be on the sample application zone, reagent zone, or test zone, or the entire test strip, and the substance may be impregnated with one or more materials of the test strip. The solution containing the signal is applied to the surface of the test strip or one or more materials of the test strip are immersed in the solution containing the signal. The test paper added with the signal-containing substance solution is dried.

The various zones of the test strip may be arranged in the following manner: the sample adding zone, the reagent zone, the detection zone, the control zone, the liquid sample absorbing zone and the liquid sample absorbing zone. The control zone is located behind the detection zone. All zones may be arranged on a strip of paper of only one material. Different materials may be used for the different regions. Each zone may be in direct contact with the liquid sample or the different zones may be arranged in accordance with the direction of flow of the liquid sample, with the ends of each zone being connected to and overlapping the front end of the other zone. The material used may be a material with good water absorption such as filter paper, glass fiber or nitrocellulose membrane. The test strip may take other forms.

Type of sample

Any type of sample can be tested with the device of the present invention, including body fluids (e.g., urine and other body fluids, as well as clinical samples). Liquid samples may be derived from solid or semi-solid samples, including fecal, biological tissue and food samples. These solid and semi-solid samples may be converted into liquid samples by any suitable method, such as mixing, stamping, macerating, incubating, dissolving or enzymatic hydrolysis of the solid samples (e.g., water, phosphate buffer or other buffers) in a suitable liquid. "biological samples" include samples derived from living animals, plants and food, as well as urine, saliva, blood and blood components, cerebrospinal fluid, vaginal swabs, semen, feces, sweat, secretions, tissues, organs, tumors, cultures of tissues and organs, cell cultures and conditioned media therein, whether human or animal. Food samples include processed food ingredients and final products, meat, cheese, wine, milk and drinking water. Plant samples include samples derived from any plant, plant tissue, plant cell culture and conditioned medium therein. "environmental samples" are those derived from the environment (e.g., lake water samples or other water samples, sewage samples, soil samples, groundwater samples, seawater samples, waste water samples). Sewage and related waste may also be contained in the environmental sample.

Type of analyte

Any analyte can be analyzed using the present invention. Examples of analytes that can be stably detected using the present invention include, but are not limited to, human chorionic gonadotropin (hCG), luteinizing Hormone (LH), ovarian hormone (FSH), hepatitis C Virus (HCV), hepatitis B Virus (HBV), hepatitis b surface antigen, aids virus, and any abused drug. Analyte energyCan be detected in any liquid or liquefied sample, such as urine, saliva, blood, plasma, or serum. Examples of other analytes are creatinine, bilirubin, nitrite, proteins (non-specific), blood, leukocytes, blood glucose, heavy metals and toxins, bacterial components (e.g., specific proteins and sugars for a particular type of bacteria, such as E.coli 0157: H7, staphylococcus aureus, salmonella, clostridium perfringens, campylobacter, listeria monocytogenes, vibrio enteritis, or Bacillus cereus). Any other suitable form of analyte for lateral flow testing may be detected using the present device. The analyte may also be an infectious agent or an agent that may be suggestive of an infectious period. The analyte may be a pharmaceutical (e.g., drug of abuse), hormone, protein, nucleic acid molecule, pathogen. "drug of abuse" (DOA) refers to the use of drugs (typically acting to paralyze nerves) in non-medical destinations. Abuse of these drugs can lead to physical and mental impairment, dependence, addiction and/or death. Examples of drug abuse include cocaine; amphetamines (e.g., black americans, white amphetamine tablets, dextroamphetamine tablets, beans); methamphetamine (crank, methamphetamine, crystal, speed); barbiturates (e.gRoche Pharmaceuticals, nutley, new Jersey); sedatives (i.e. sleep aid drugs); lysergic acid diethylamide (LSD); inhibitors (downs, goofball, barbs, blue devils, yellow sockets, hypnone); tricyclic antidepressants (TCAs, i.e., imipramine, amitriptyline, and doxepin); phencyclidine (PCP); tetrahydrocannabinol (THC, point, rope, hash, wet, etc.); opiates (i.e., morphine, opium, codeine, heroin, oxycodone). The test strip can also be used for medical application but is easy to take excessive drugs, such as tricyclic antidepressants (promethazine or analogues) and acetaminophen. />

Claims

1. A device for detecting an analyte in a sample, the device comprising: a collection chamber for receiving a liquid sample, the collection chamber including an opening; a test element for testing an analyte in a liquid sample; and a cover for covering the collection chamber opening; the device also comprises a prompting device for prompting whether the cover body is covered on the designated position on the collecting cavity, wherein the prompting device prompts by sending out sound, the prompting device comprises a non-elastic element and an elastic element, the non-elastic element is positioned on the collecting cavity, the elastic element is positioned on the cover body, and the elastic element is a part of the cover edge of the cover body; the elastic element is of a rectangular structure, two long sides of the rectangular structure are provided with gaps with other parts of the cover edge of the cover body, one short side is connected with the cover edge, and the other short side is exposed; the elastic element has a raised structure on the inner or outer surface of the exposed short side; the outer wall of the collecting cavity is provided with the inelastic element, and the inelastic element is contacted with the protruding structure of the elastic element in the process of rotating and covering the external threads of the collecting cavity and the internal threads of the cover body, so that the elastic element is deformed; the deformation direction is far away from the peripheral plane of the cover; the protruding structure and the elastic element are the same in material, and the thickness of the protruding structure is greater than that of the elastic element.

2. The device of claim 1, wherein the raised structures have a greater elastic modulus than the elastic modulus of the elastic member.

3. The device of claim 1, wherein the collection chamber has external threads and the cap has internal threads for mating with the external threads, and wherein the resilient member on the cap has no internal threads.