CN108221086A - 一种天然氨基酸交联的海藻酸钙纤维 - Google Patents

一种天然氨基酸交联的海藻酸钙纤维 Download PDF

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CN108221086A
CN108221086A CN201810122768.4A CN201810122768A CN108221086A CN 108221086 A CN108221086 A CN 108221086A CN 201810122768 A CN201810122768 A CN 201810122768A CN 108221086 A CN108221086 A CN 108221086A
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薛涵与
叶远松
李心忠
林棋
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Abstract

本发明公开了一种天然氨基酸交联的海藻酸钙纤维，所述纤维的制备方法如下：将海藻酸盐和天然氨基酸的二钠盐按质量比100:1~100:30溶解于pH=6.5的稀盐酸溶液中，然后添加氯化钙形成纤维状胶体，最后通过湿法纺丝制备成纤维，即制得天然氨基酸交联的海藻酸钙纤维。本发明利用L‑胱氨酸医药领域和酸碱可逆交联的特性，实现海藻酸钙纤维促进伤口愈合和快速降解的多功能化。这种天然氨基酸交联的海藻酸钙纤维有望应用于纺织、医疗卫生等领域。

Description

一种天然氨基酸交联的海藻酸钙纤维
技术领域
本发明属于海藻酸钙纤维的改性领域，具体涉及一种天然氨基酸交联的海藻酸钙纤维。
背景技术
海藻酸钙纤维通常是海藻酸钠与钙离子形成的凝胶，并通过湿法纺丝制得的一种天然纤维，具有热不可逆性。海藻酸钙纤维通以其优异的生物相容性、高吸湿性、止血性、成胶性、促进伤口愈合性、抑菌性和可生物降解性等特性，广泛应用于纺织纤维、医药卫生等领域。作为纺织纤维，海藻酸钙纤维热不可逆性导致其降解速率慢。而作为医用敷料纤维，海藻酸钙纤维能够与组织渗液发生Na+/Ca2+离子交换，在创口表面形成一层稳定的网状凝胶，并通过微酸、无氧或低氧、适度湿润的伤口环境促进生长因子释放，促进伤口愈合。然而目前市售海藻酸钙纤维医用敷料往往需要另外添加抗菌剂，以避免复杂伤口环境导致的海藻酸钙医用敷料功能失效。
发明内容
本发明的目的在于针对现有技术的不足，提供一种天然氨基酸交联的海藻酸钙纤维。通过将具有酸碱可逆交联功能性的天然氨基酸引入到海藻酸钙纤维中，同时实现了海藻酸钙纤维的快速降解功能化和药物缓释功能化，达到了海藻酸钙纤维快速回收和促进伤口愈合的目的。
为实现上述目的，本发明采用如下技术方案：
一种天然氨基酸交联的海藻酸钙纤维的制备方法：海藻酸盐和天然氨基酸的二钠盐按质量比100:1~100:30溶解于pH=6.5的稀盐酸溶液中，然后添加25wt%氯化钙溶液形成纤维状胶体，最后通过湿法纺丝制备成纤维，即制得所述天然氨基酸交联的海藻酸钙纤维。
所述原料海藻酸盐为海藻酸锂、海藻酸钠、海藻酸钾中的一种。
所述天然氨基酸的二钠盐作为交联剂，包括L-高胱氨酸二钠盐、DL-高胱氨酸二钠盐、L-胱氨酸二钠盐、DL-胱氨酸二钠盐中的任一种。
一种如上所述的制备方法制得的天然氨基酸交联的海藻酸钙纤维具备快速降解特性、良好的生物相容性、高吸湿性，作为医用敷料纤维使用时具有比海藻酸盐类医用敷料更加优异的促进伤口愈合和抑菌性。
一种如上所述的天然氨基酸交联的海藻酸钙纤维的使用方法：作为普通纺织纤维，天然氨基酸交联的海藻酸钙纤维在pH>10的环境下，可使天然氨基酸中所含可逆反应的二硫键基团解交联，实现海藻酸钙纤维的解交联；作为医用敷料纤维时，海藻酸钙纤维在伤口处与组织渗液发生Na+/Ca2+离子交换，使得天然氨基酸与海藻酸钙纤维的解离，实现天然抗菌药物的缓释，促进伤口愈合和抑菌。
本发明的有益效果在于：
现有二硫键交联的海藻酸盐纤维采用含巯基化合物接枝到海藻酸盐纤维上，再通过巯基还原为二硫键交联点，制备方法复杂且后处理困难。本发明采用离子键交联海藻酸钙纤维，步骤简单，后处理方便。改性后的树脂具备海藻酸钙纤维的优异性能如生物相容性、高吸湿性、止血性、成胶性和可生物降解性等特性，多功能化则实现了海藻酸钙纤维的快速降解性和天然抗菌药物的缓释性，具备比现有海藻酸钙纤维更加优异的促进伤口愈合性和抑菌性。该天然氨基酸交联的海藻酸钙纤维有望应用于纺织纤维和医用纤维等领域。
附图说明
图1为本发明的海藻酸盐原料结构式；
图2为本发明的天然氨基酸交联的海藻酸钙纤维的制备机理；
图3为本发明的天然氨基酸交联的海藻酸钙纤维的快速降解功能化示意图；
图4为本发明的天然氨基酸交联的海藻酸钙纤维的药物缓释功能化示意图。
具体实施方式
下面结合实施例对本发明的技术方案作进一步的描叙，但不受限于这些实施例。
实施例 1
海藻酸钠和L-胱氨酸二钠盐按质量比100:8溶解于pH=6.5的稀盐酸溶液中，然后添加25wt%氯化钙溶液形成纤维状胶体，最后通过湿法纺丝制备成纤维，得到天然氨基酸交联的海藻酸钙纤维。该纤维的吸湿率达到104%，对大肠杆菌的抗菌率达到30.5%，对金色葡萄球菌的抗菌率达到45.8%。
实施例 2
海藻酸钾和DL-胱氨酸二钠盐按质量比100:5溶解于pH=6.5的稀盐酸溶液中，然后添加25wt%氯化钙溶液形成纤维状胶体，最后通过湿法纺丝制备成纤维，得到天然氨基酸交联的海藻酸钙纤维。该纤维的吸湿率达到101%，对大肠杆菌的抗菌率达到30.1%，对金色葡萄球菌的抗菌率达到44.9%。
实施例3
海藻酸锂和L-高胱氨酸二钠盐按质量比100:15溶解于pH=6.5的稀盐酸溶液中，然后添加25wt%氯化钙溶液形成纤维状胶体，最后通过湿法纺丝制备成纤维，得到天然氨基酸交联的海藻酸钙纤维。该纤维的吸湿率达到99%，对大肠杆菌的抗菌率达到30.9%，对金色葡萄球菌的抗菌率达到44.2%。
实施例4
海藻酸钠和DL-高胱氨酸二钠盐按质量比100:30溶解于pH=6.5的稀盐酸溶液中，然后添加25wt%氯化钙溶液形成纤维状胶体，最后通过湿法纺丝制备成纤维，得到天然氨基酸交联的海藻酸钙纤维。该纤维的吸湿率达到102.9%，对大肠杆菌的抗菌率达到32.3%，对金色葡萄球菌的抗菌率达到45.1%。
以上所述仅为本发明的较佳实施例，凡依本发明申请专利范围所做的均等变化与修饰，皆应属本发明的涵盖范围。

Claims (6)

1.一种天然氨基酸交联的海藻酸钙纤维的制备方法，其特征在于：将海藻酸盐和天然氨基酸的二钠盐按质量比100:1~100:30溶解于pH=6.5的稀盐酸溶液中，然后添加25wt%氯化钙溶液形成纤维状胶体，最后通过湿法纺丝制备成纤维，即制得所述天然氨基酸交联的海藻酸钙纤维。
2.根据权利要求1所述的天然氨基酸交联的海藻酸钙纤维的制备方法，其特征在于：所述原料海藻酸盐为海藻酸锂、海藻酸钠和海藻酸钾中的任一种。
3.根据权利要求1所述的天然氨基酸交联的海藻酸钙纤维的制备方法，其特征在于：所述天然氨基酸的二钠盐包括L-高胱氨酸二钠盐、DL-高胱氨酸二钠盐、L-胱氨酸二钠盐和DL-胱氨酸二钠盐中的任一种。
4.一种如权利要求1-3任一项所述的制备方法制得的天然氨基酸交联的海藻酸钙纤维。
5.一种如权利要求4所述的天然氨基酸交联的海藻酸钙纤维的使用方法，其特征在于：所述天然氨基酸交联的海藻酸钙纤维作为纺织纤维和医用敷料纤维使用。
6.根据权利要求5所述的使用方法，其特征在于：作为纺织纤维时，天然氨基酸交联的海藻酸钙纤维在pH>10的环境下，可使天然氨基酸中所含可逆反应的二硫键基团解交联，实现海藻酸钙纤维的解交联；作为医用敷料纤维时，海藻酸钙纤维在伤口处与组织渗液发生Na+/Ca2+离子交换，使得天然氨基酸与海藻酸钙纤维的解离，实现天然抗菌药物的缓释，促进伤口愈合和抑菌。
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