CN108210644A - Treat infections chicken cloacal bursa（Sweet Borrow）Drug and preparation method thereof - Google Patents
Treat infections chicken cloacal bursa（Sweet Borrow）Drug and preparation method thereof Download PDFInfo
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- CN108210644A CN108210644A CN201611158730.XA CN201611158730A CN108210644A CN 108210644 A CN108210644 A CN 108210644A CN 201611158730 A CN201611158730 A CN 201611158730A CN 108210644 A CN108210644 A CN 108210644A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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Abstract
The present invention relates to a kind of tablets with treatment infections chicken cloacal bursa (sweet Borrow) and preparation method thereof, and constituent component is：180 200 parts of pueraria lobata, 160 180 parts of isatis root, 80 100 parts of subprostrate sophora, 46 parts of realgar, 40 50 parts of Radix Glycyrrhizae, 160 180 parts of mung bean flour, 40 parts of radix scutellariae, 16 24 parts of the coptis prolong and entangle 40 parts recklessly, and 60 80 parts of folium isatidis fills 100 200 parts of auxiliary material.The preparation method of the present invention first mixes a variety of Chinese medicine composition, important component is mixed with auxiliary slow-release material again, it is interior that such preparation method can make slow-release material be wrapped in active ingredient, accelerate drug effect dissolving release time, drug effect is enable to discharge in a short time.Drug therapy Bursal Disease curative effect of the present invention is fast, and cure rate is high, environmental protection, and cost is relatively low.
Description
Technical field
The invention belongs to field of medicine preparing technology, especially a kind of drug for treating infections chicken cloacal bursa (sweet Borrow)
And preparation method thereof.
Background technology
Bursal Disease (IBD), i.e., sweet Borrow's disease, also known as infectious bursal disease, are infectious bursa of Fabricius
A kind of acute, highly contagious disease caused by virus.Infectious bursa of Fabricius virus belongs to birnavirus section, including two blood
Clear type.Characterized by bursa of farbricius inflammation, necrosis, atrophy and bursa of farbricius endolymph cell are badly damaged.So as to cause the immune of chicken
Dysfunction interferes the immune effect of various vaccines.Since disease morbidity is unexpected, the course of disease is short, the death rate is high, and can cause chicken body
Immunosupress is still one of Infectious Diseases of poultry husbandry at present.
The invention drug can influence the rate of dissolution of drug, and quick release simultaneously reaches action target spot, so as to reduce sweet Borrow
The acute attack of disease can improve the bioavilability of drug.It can be disintegrated rapidly and be dispersed into thin before drug reaches gastrointestinal tract
Micro- particle causes drug to be distributed in gastrointestinal tract large area, absorbs point and increases, and the part of gastrointestinal tract is pierced so as to reduce drug
Swash.Improve the mouthfeel of preparation using aspartame in the preparation, greatly improve drug compliance, solve the problems, such as that medication is difficult.
The invention drug absorption is fast, bioavilability is high, instructions of taking, in good taste, enteron aisle remains less, side effect is low, keeps away
Exempt from the first pass effect of liver, and cost is relatively low.
Invention content
Treatment chicken fast, that bioavilability is high, enteron aisle remains less, side effect is low is absorbed the purpose of the present invention is to propose to a kind of
Infectious bursa of Fabricius (sweet Borrow) drug and preparation method thereof.
The present invention realizes that the technical solution of purpose is：
A kind of to treat infections chicken cloacal bursa (sweet Borrow) tablet, constituent component and its parts by weight are respectively：
180-200 parts of pueraria lobata, 160-180 parts of isatis root, 80-100 parts of subprostrate sophora, 4-6 parts of realgar, 40-50 parts of Radix Glycyrrhizae are green
160-180 parts of bean powder, 40 parts of radix scutellariae, 16-24 parts of the coptis prolong and entangle 40 parts recklessly, and 60-80 parts of folium isatidis fills auxiliary material 100-200
Part.
Filling auxiliary material and its weight ratio are：Microcrystalline cellulose 25g, low-substituted hydroxypropyl cellulose (L-HPC) 7g, lactose
20g, aspartame 8g, fresh milk king essence 5g, saccharin sodium 0.2g, gypsum 34.8g.
The advantages of the present invention are：
(1) present invention is soluble, uniform in gastrin IR cells, and drug was in Entogastric lingering 5.5 hours, and enteron aisle residual is few, and pair is made
With low, absorb that fast, bioavilability is high, the stability in hydrochloric acid in gastric juice eroding drug, being conducive to increase drug can be avoided, can chicken infect
Property bursal disease carry out local treatment.
(2) production equipment of the present invention is simple, operation is easy, and weight differential is small, at low cost, saves raw material, environmental protection.
Specific embodiment
Below by specific embodiment, the invention will be further described, and following embodiment is descriptive, is not limit
Qualitatively, it is impossible to which protection scope of the present invention is limited with this.
Embodiment：
180-200 parts of pueraria lobata, 160-180 parts of isatis root, 80-100 parts of subprostrate sophora, 4-6 parts of realgar, 40-50 parts of Radix Glycyrrhizae are green
160-180 parts of bean powder, 40 parts of radix scutellariae, 16-24 parts of the coptis prolong and entangle 40 parts recklessly, and 60-80 parts of folium isatidis fills auxiliary material 100-200
Part.
Filling auxiliary material and its weight ratio are：Microcrystalline cellulose 25g, low-substituted hydroxypropyl cellulose (L-HPC) 7g, lactose
20g, aspartame 8g, fresh milk king essence 5g, saccharin sodium 0.2g, gypsum 34.8g.
Preparation methods steps are：
(1) by required major ingredient in 35-40 DEG C of drying；
(2) major ingredient be crushed into 80 mesh sieve in parts by weight；
(3) be added portionwise in parts by weight microcrystalline cellulose excipients, low-substituted hydroxypropyl cellulose, lactose, aspartame,
Fresh milk king essence, saccharin sodium add, and abundant mixing when adding auxiliary material to major ingredient in a manner that equivalent is progressively increased, and form powder mixing
Object；
(4) ethanol solution is uniformly sprayed into mixture of powders, softwood is made；
(5) with 20 mesh sieve series grains, 50-60 DEG C dries 1-2 hours；
(6) 20 mesh sieve whole grain is crossed respectively, is added in gypsum in parts by weight and is uniformly mixed；
(7) it is tabletted to obtain the final product.
Claims (4)
1. one kind has treatment infections chicken cloacal bursa (sweet Borrow) drug, it is characterised in that：180-200 parts of pueraria lobata, isatis root
160-180 parts, 80-100 parts of subprostrate sophora, 4-6 parts of realgar, 40-50 parts of Radix Glycyrrhizae, 160-180 parts of mung bean flour, 40 parts of radix scutellariae, the coptis
16-24 parts, prolong and entangle 40 parts recklessly, 60-80 parts of folium isatidis fills 100-200 parts of auxiliary material.
2. the preparation method of infections chicken cloacal bursa (sweet Borrow) drug, preparation methods steps are according to claim 1：
(1) by required major ingredient in 35-40 DEG C of drying；
(2) major ingredient be crushed into 80 mesh sieve in parts by weight；
(3) microcrystalline cellulose excipients, low-substituted hydroxypropyl cellulose, lactose, aspartame, fresh milk are added portionwise in parts by weight
Wang Xiangjing, saccharin sodium add, and abundant mixing when adding auxiliary material to major ingredient in a manner that equivalent is progressively increased, and form mixture of powders；
(4) ethanol solution is uniformly sprayed into mixture of powders, softwood is made；
(5) with 20 mesh sieve series grains, 50-60 DEG C dries 1-2 hours；
(6) 20 mesh sieve whole grain is crossed respectively, is added in gypsum in parts by weight and is uniformly mixed；
(7) it is tabletted to obtain the final product.
3. the preparation method of infections chicken cloacal bursa (sweet Borrow) drug according to claim 2, it is characterised in that：The second
A concentration of the 75% of alcoholic solution.
4. the preparation method of infections chicken cloacal bursa (sweet Borrow) drug according to claim 2, it is characterised in that：It is described etc.
It measures the addition manner that progressively increases and is directed to major ingredient moderate and add in each auxiliary material, and the lower batch of amount for adding in auxiliary material is accumulative before total
Amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611158730.XA CN108210644A (en) | 2016-12-15 | 2016-12-15 | Treat infections chicken cloacal bursa（Sweet Borrow）Drug and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611158730.XA CN108210644A (en) | 2016-12-15 | 2016-12-15 | Treat infections chicken cloacal bursa（Sweet Borrow）Drug and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108210644A true CN108210644A (en) | 2018-06-29 |
Family
ID=62651138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611158730.XA Pending CN108210644A (en) | 2016-12-15 | 2016-12-15 | Treat infections chicken cloacal bursa（Sweet Borrow）Drug and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108210644A (en) |
-
2016
- 2016-12-15 CN CN201611158730.XA patent/CN108210644A/en active Pending
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180629 |
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| WD01 | Invention patent application deemed withdrawn after publication |