CN108210360A - A kind of water solubility whitening formula and its preparation method and application - Google Patents
A kind of water solubility whitening formula and its preparation method and application Download PDFInfo
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- CN108210360A CN108210360A CN201810117931.8A CN201810117931A CN108210360A CN 108210360 A CN108210360 A CN 108210360A CN 201810117931 A CN201810117931 A CN 201810117931A CN 108210360 A CN108210360 A CN 108210360A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/49—Solubiliser, Solubilising system
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Abstract
The present invention provides a kind of water-soluble whitening formula, including 4 (1 phenethyl) 1,3 benzenediol, poloxamer, water, moisturizer, skin sense conditioning agent and protective system.The formula can significantly improve 4 (1 phenethyl) 1,3 benzenediol dissolubility in water, enhancing stability, reduce irritation to skin, while the whitening formula also has effects that be sustained.The invention further relates to the preparation methods and purposes of above-mentioned whitening formula.
Description
Technical field
The invention belongs to cosmetics and its preparing technical fields, and in particular to one kind is based on 4- (1- phenethyls) -1,3- benzene
Water-soluble whitening formula, the preparation method and its usage of diphenol.
Background technology
In cosmetic field, whitening product has the powerful market demand, particularly in view of Asian is for whitening
Strong needs.The pale degree of human body complexion depends primarily on the ability of melanocyte synthesis of melanin, melanin generation
More, skin is pitch-darker；Conversely, then skin is more pale.Tyrosinase is the key enzyme of B16 cell, its activity is big
The small content for determining human body melanin, so as to affect the pale degree of human body complexion.Whitening product in cosmetics at present
In active ingredient whitening principle be typically inhibit tyrosinase activity, reduce the generation of melanin, and then play whitening
Effect.For example, currently on the market the whitening composition ursin in popular skin-lightening cosmetic, vitamin C derivatives, kojic acid and its
Chinese medical extracts such as derivative, green-tea extract, licorice etc. are tyrosinase inhibitor, by inhibiting tyrosinase
Activity and reach inhibition B16 cell, and then play skin whitening effect.
4- (1- phenethyls)-Resorcinol is a kind of whitening composition with potent whitening function, can improve the colour of skin
Uneven problem reduces pigmenting of skin caused by ultraviolet light irradiation skin.Its tyrosinase restraint is 22 times of kojic acid, to black
The restraint of pigment oncocyte is far above kojic acid and ursin, is one of ideal whitening raw material selection of whitening product.4- (1- benzene
Ethyl) the entitled Phenylethyl Resorcinol of-Resorcinol INCI, No. CAS is 85-27-8, and molecular formula is
C14H14O2.In December, 2012, State Food and Drug Administration formally have by fragrant (Shanghai) of applicant of the present invention's moral
The application of limit company, approval 4- (1- phenethyls)-Resorcinols are used for cosmetic material, have been widely used at present in each
Kind whitening, nti-freckle, anti-aging product.
But 4- (1- phenethyls)-Resorcinol is while with high whitening active, it may have the defects of unstability,
It is the substance of a kind of light, thermally labile, easily and metal ion-chelant, is easily aoxidized, be insoluble in water, it is variable in aqueous solution
Color.These defects seriously affect the exterior appearance of the whitening product based on 4- (1- phenethyls)-Resorcinol, and cause to live
Sexual element is lost in during storage, and the bioavilability that low aqueous solubility also further results in whitening active composition is low, whitening work(
It imitates limited.Using common cosolvent, such as surfactant, it can not also be obviously improved 4- (1- phenethyls)-Resorcinol
Slightly solubility can not prepare 4- (1- phenethyls)-Resorcinol aqueous solution.
In order to solve 4- (1- phenethyls)-Resorcinol drawbacks described above, the prior art is by 4- (1- phenethyls) -1,3-
Benzenediol is prepared into emulsion, and wherein 4- (1- phenethyls)-Resorcinol is present in oil phase, such as presently commercially available contains 4-
The product of (1- phenethyls)-Resorcinol has the UV＆White Enrich Lift Sunscreen Cream of city open country doctor,
Ultrasun Extreme etc. are the emulsion form of emulsifying or the product of cream shape.But 4- (1- phenethyls) -1,3- benzene two
Phenol emulsion still has many defects, it, which has formula and technique, particularly investigates, dependent on emulsifying technology, for oil
The selection of fat, proportioning, preparation process have very high requirement, and the selectivity of formula is narrow.In addition emulsification dosage form determines this
The product type of class whitening product is limited, is prepared into emulsifiable paste or lotion more, can not be prepared into essence, facial mask liquid etc., and due to skin
The obstruction of the presence of the barrier action of skin, especially cuticula leads to the assimilation effect of 4- (1- phenethyls)-Resorcinol not
It is good, the waste of active ingredient is caused, whitening effect is had a greatly reduced quality.
In the prior art, 4- (1- phenethyls)-Resorcinol whitening preparation is also prepared into dual products, including powder
End and two independent parts of liquid, client need voluntarily to be used in mixed way, and fully dissolve before use after point of purchase, to
The activity of 4- (1- phenethyls)-Resorcinol is kept in short time, it is made not have apparent discoloration.This dual products are led
Cause the trouble in client's use.
Invention content
In view of above-mentioned 4- in the prior art (1- phenethyls)-many defects existing for Resorcinol whitening product, having must
A kind of water-soluble plukenetia white preparation that can improve 4- (1- phenethyls)-Resorcinol stability and white-skinned face function is provided, and
With long quality guarantee period.
The present invention relates to a kind of solubilization techniques, can be very good to help 4- (1- phenethyls)-Resorcinol in water phase body
Dissolving in system, and the negative effects such as stimulation will not be caused.4- (1- phenethyls) -1, the 3- benzene two prepared using the solubilization technique
The formulation stability of phenol whitening formula is high, and cosmetics type applicatory is extensive, can give full play to 4- (1- phenethyls) -1,3-
The white-skinned face function of benzenediol, has a good application prospect.
Inventor has been surprised to find poloxamer to 4- (1- phenethyls) -1,3- benzene two by in-depth study repeatedly
Phenol has prominent solubilization-aid effect, and 4- (1- phenethyls)-Resorcinol water can be prepared by the use of poloxamer as cosolvent
Dissolubility whitening preparation.4- (1- phenethyls) -1,3- benzenediol water-soluble plukenetias white preparation prepared in accordance with the present invention has prominent
Technique effect can significantly improve the solubility and stability of 4- (1- phenethyls)-Resorcinol in water, can be in longer guarantor
It stays pale in the matter phase white-skinned face function of active ingredient.In addition, inventor also found 4- prepared in accordance with the present invention (1- benzene second
Base) the technique effect of-Resorcinol water-soluble plukenetia white preparation with protrusion in terms of sustained release, skin sense is greatly improved, and improve
Active constituent availability.
Specifically, the present invention proposes one kind and is based on 4- (1- phenethyls)-Resorcinol water solubility whitening formula, including
Following components：4- (1- phenethyls) -1,3- benzenediols and poloxamer, wherein poloxamer are as 4- (1- phenethyls) -1,3-
The cosolvent of benzenediol.
Further, the water-soluble whitening formula further includes moisturizer.
Further, the water-soluble whitening formula further includes skin sense conditioning agent.
Further, the whitening formula further includes protective system.
Further, the whitening formula further includes other co-solvent components.
Further, the whitening formula further includes other whitening active ingredients.
Further, the adding proportion of 4- (1- the phenethyls)-Resorcinol is less than 5wt% (wt%：Quality percentage
Than).
Further, the adding proportion of the poloxamer is less than 15%.
Further, the ratio between mass percent of 4- (1- the phenethyls)-Resorcinols and poloxamer is less than 1:
8。
Further, the adding proportion of the moisturizer is less than 30wt%.
Further, the adding proportion of the skin sense conditioning agent is less than 20wt%.
Further, the adding proportion of the protective system is less than 10wt%.
Further, the moisturizer is selected from glycerine, 1,3-BDO, propylene glycol, pentanediol, hexylene glycol, sorbierite etc.
The polysaccharides such as polyalcohol, amides, trehalose, glucose/glucose esters, fructose, urea, allantoin, lactic acid/sodium lactate,
One or more of the natural moisturizing factor such as Anjidew NL50, glycine betaine, polyethylene glycols, panthenol, niacinamide, chitosan class.
Further, the skin sense conditioning agent is selected from glucan, hyaluronic acid/Sodium Hyaluronate, Pulan sugar, alginic acid
One or more of sodium, xanthans, glucose, trehalose, fructose, maltose.
Further, the protective system be selected from parahydroxyacet-ophenone, sorbic acid/potassium sorbate, Phenoxyethanol, to hydroxyl
Benzoates, polyalcohols, Chlorphenesin, glycerol caprylate, dehydroactic acid and its esters, salicylic acid/sodium salicylate, benzene first
One or more of acid, iodine propilolic alcohol butyl mephenesin Carbamate, the smooth caprylate of sorb, anisic acid.
Further, the water-soluble whitening formula is aqueous solution or gel.
The present invention also provides a kind of purposes of above-mentioned water-soluble whitening formula in cosmetics, the water solubility whitening formulas
Available for preparing facial mask liquid, lotion, essence.
The present invention also provides a kind of preparation method of water-soluble whitening formula, using poloxamer as cosolvent, by 4-
(1- phenethyls) -1,3- benzenediols are dissolved in the water.
Further, include the following steps：
Step 1：Poloxamer is added to the water, stirs to solution and clarifies；
Step 2：4- (1- phenethyls)-Resorcinol is added in, stirs to solution and clarifies；
Step 3：Add in other components.
Further, the other components further include one or more in moisturizer, skin sense conditioning agent and protective system.
Further, the moisturizer is selected from glycerine, 1,3-BDO, propylene glycol, pentanediol, hexylene glycol, sorbierite etc.
The polysaccharides such as polyalcohol, amides, trehalose, glucose/glucose esters, fructose, urea, allantoin, lactic acid/sodium lactate,
One or more of the natural moisturizing factor such as Anjidew NL50, glycine betaine, polyethylene glycols, panthenol, niacinamide, chitosan class.
Further, the skin sense conditioning agent is selected from glucan, hyaluronic acid/Sodium Hyaluronate, Pulan sugar, alginic acid
One or more of sodium, xanthans, glucose, trehalose, fructose, maltose.
Further, the protective system be selected from parahydroxyacet-ophenone, sorbic acid/potassium sorbate, Phenoxyethanol, to hydroxyl
Benzoates, polyalcohols, Chlorphenesin, glycerol caprylate, dehydroactic acid and its esters, salicylic acid/sodium salicylate, benzene first
One or more of acid, iodine propilolic alcohol butyl mephenesin Carbamate, the smooth caprylate of sorb, anisic acid.
Further, the adding proportion of the moisturizer is less than 30wt%.
Further, the adding proportion of the skin sense conditioning agent is less than 20wt%.
Further, the adding proportion of the protective system is less than 10wt%.
Further, the additive amount of 4- (1- the phenethyls)-Resorcinol is less than 5wt%.
Further, the additive amount of the poloxamer is less than 15wt%.
Further, 4- (1- the phenethyls)-Resorcinols and the mass percent of poloxamer in formula it
Than being less than 1:8.
Further, the whitening formula being prepared into is aqueous solution or gel.
Further, the whitening formula being prepared into can be used for preparing facial mask liquid, lotion, essence.
According to the technique and scheme of the present invention, it can prepare that a kind of white-skinned face function is strong, stability is good based on 4- (1- benzene second
Base) -1,3- benzenediols water-soluble whitening formula.Further, which can increase skin to 4- (1- phenethyls) -1,
The absorptivity of 3- benzenediols also with slow releasing function, improves the utilization rate of active constituent.
In addition, compared to the whitening emulsion formulations based on 4- (1- phenethyls)-Resorcinol, technical solution of the present invention carries
The preparation method of 4- (1- phenethyls)-Resorcinol water solubility whitening formula of confession is simple and practicable, and technology difficulty is low.
Further, because of 4- (1- phenethyls)-Resorcinol water solubility whitening formula according to technical solution of the present invention
With very high stability, when preparing the water-soluble whitening product based on 4- (1- phenethyls)-Resorcinol, without being made
Need buyer voluntarily mixed dissolution and needing use in a short time include powder and the two-part dual products of liquid,
But unitary product can be directly prepared into, buyer can directly use, and can store for a long time, keep 4- in a long time
The stability and whitening active of (1- phenethyls) -1,3- benzenediols.
Description of the drawings
Fig. 1 is the preparation method flow chart of the water-soluble whitening formula of 4- (1- phenethyls) -1,3- benzenediols of the present invention.
Fig. 2 is the preparation of the water-soluble whitening and moistening skin gel of 4- (1- phenethyls) -1,3- benzenediols in the embodiment of the present invention 1
Method.
Specific embodiment
Below in conjunction with specific embodiment, to the water of the present invention based on 4- (1- phenethyls)-Resorcinol
Dissolubility whitening formula, preparation method and its usage are described in detail, in order to the public be allowed to be better understood from the skill
Art content rather than the technology contents are limited, in fact, with identical or approximate principle to the formula, system
The improvement that Preparation Method and application thereof carries out, all within present invention right claimed.
The water-soluble whitening formula of 4- (1- phenethyls) -1,3- benzenediols of the present invention includes following components：
Whitening active composition 4- (1- phenethyls) -1,3- benzenediols；
Cosolvent poloxamer.
In general, further include aqueous solvent, moisturizer, skin sense conditioning agent and protective system in the whitening formula of the present invention.
Inventive principle
In the present invention, with poloxamer prepare 4- (1- phenethyls)-Resorcinol water-soluble plukenetia white preparation have with
The protrusion technique effect of lower several respects：1st, the solubility of 4- (1- phenethyls)-Resorcinols in water, shape can significantly be increased
Into colourless uniform aqueous solution；2nd, poloxamer makes itself and external environment phase by wrapping up 4- (1- phenethyls) -1,3- benzenediols
Isolation increases the stability of active ingredient 4- (1- phenethyls)-Resorcinol, is allowed to not easy to change, improves whitening effect；3、
With slow releasing function.
Poloxamer is polyoxyethylene poly-oxygen propylene aether block copolymer, is on the whole hydrophilic polymer, wherein polyoxy second
Alkene segment has hydrophily and polyoxypropylene segment has hydrophobicity.Inventor is had found by furtheing investigate, by poloxamer and 4- (1-
Phenethyl)-Resorcinol is dispersed in water, and poloxamer can form a kind of reticular structure, and by 4- (1- phenethyls) -1,
3- benzenediols wrap up wherein, and the hydrophilic group of outer layer of poloxamer reticular structure is connected with hydrone, the lipophilic group of internal layer
It is connected with 4- (1- phenethyls) -1,3- benzenediols.This reticular structure considerably increases 4- (1- phenethyls) -1,3- benzenediols and exists
Solubility in water has solubilizing effect well.Further, because 4- (1- phenethyls)-Resorcinol be wrapped it is on the berth
In Luo Shamu ball reticular structures, the effect with external environment isolation is realized, and then significantly increase 4- (1- phenethyls) -1,3- benzene
The stability of diphenol, even across the long period, which can still keep the achromaticity and clarification of appearance, and
The ratio of whitening active composition will not reduce.
Further, inventor also found that the reticular structure of poloxamer has certain space in itself in the course of the research
Stability has 4- (1- phenethyls)-Resorcinol prominent slow releasing function.Different from common 4- (1- benzene second
Base)-Resorcinol whitening product, in 4- of the invention (1- phenethyls)-Resorcinol water solubility whitening formula activity into
Part will not abrupt release, but slow release.In normal state, 4- (1- phenethyls)-Resorcinol effective ingredient is stablized
It is present in poloxamer reticular structure, and when product is coated on skin, based on reticular structure and skin contact or based on pressure
Power friction causes reasons, the active ingredients such as reticular structure destruction to start to be slowly released, and then play slow releasing function and improved
Imitate ingredients Biogenic availability.
Further, as water-soluble polymer, poloxamer will not be caused to stimulate and be destroyed to skin in itself, therefore will
It can't influence the safety of product as one of cosmetic ingredient.And general surfactant is often small molecule and salt,
It is all bigger for the permeability and irritation of skin, it is not suitable for use in the matrix component of the cosmetics such as facial mask, and can not realize
Slow releasing function, such as 10% aqueous solution of typical surfactant such as lauryl sodium sulfate, can inherently cause skin
Stimulation is not suitable for the matrix component for being used as the cosmetics such as facial mask.
Moisturizer
It should be noted that 4- (1- phenethyls)-Resorcinol water solubility whitening formula of the present invention is for moisturizer
And its content does not have special limitation.Common moisturizer is used equally in technical scheme of the present invention in cosmetics.It is common
Moisturizer is a kind of hydrophilic Emollient materials, has the ability with reference to water in relatively low humidity range, by control product with
The exchange of moisture makes skin be maintained above the equilibrium state of normal water content between surrounding air, so as to play moisture-keeping function.
Moisturizer is added in technical scheme of the present invention can increase the guarantor of 4- (1- phenethyls) -1,3- benzenediol water solubility whitening formulas
Wet performance.It is more that preferred moisturizer can be selected from 13, glycerine, 1,3 butylene glycol, propylene glycol, pentanediol, hexylene glycol, sorbierite etc.
The polysaccharides such as first alcohol, amides, trehalose, glucose/glucose esters, fructose, urea, allantoin, lactic acid/sodium lactate, PCA
One or more of the natural moisturizing factor such as sodium, glycine betaine, polyethylene glycols, panthenol, niacinamide, chitosan class.Preferably,
The adding proportion of moisturizer is less than 30wt%.
Skin sense conditioning agent
It should be noted that 4- (1- phenethyls)-Resorcinol water solubility whitening formula of the present invention is for skin sense tune
Section agent and its content do not have special limitation.Common skin sense conditioning agent is used equally for technical scheme of the present invention in cosmetics
In.Preferred skin sense conditioning agent can be selected from glucan, hyaluronic acid/Sodium Hyaluronate, Pulan sugar, sodium alginate, xanthans,
One or more of glucose, trehalose, fructose, maltose.Preferably, the adding proportion of skin sense conditioning agent is less than
20wt%.
Protective system
It should be noted that 4- (1- phenethyls)-Resorcinol water solubility whitening formula of the present invention is for anti-corrosion body
System and its content do not have special limitation.Common protective system is used equally in technical scheme of the present invention in cosmetics.It is excellent
The protective system of choosing can be selected from hydroxy acetophenone, sorbic acid/potassium sorbate, Phenoxyethanol, parabens, polynary
Alcohols, Chlorphenesin, glycerol caprylate, dehydroactic acid and its esters, salicylic acid/sodium salicylate, benzoic acid, iodine propilolic alcohol butyl
One or more of the smooth caprylate of mephenesin Carbamate, sorb, anisic acid.Preferably, the adding proportion of protective system is less than 10%
wt。
Poloxamer
It should be noted that 4- (1- phenethyls)-Resorcinol water solubility whitening formula of the present invention is husky for pool Lip river
The concrete type of nurse does not have special limitation, and any poloxamer polymer that can realize the object of the invention belongs to the present invention
Protection domain within.Poloxamer is a kind of polyoxypropylene hydrophobic by middle part (more (propylene oxides)) chain side connection two
The nonionic formula triblock copolymer that section hydrophilic polyoxyethylene (more (ethylene oxides)) is formed.
The ratio of 4- (1- phenethyls) -1,3- benzenediols and poloxamer
It should be noted that 4- (1- phenethyls)-Resorcinol water solubility whitening formula of the present invention is for 4- (1- benzene
Ethyl)-Resorcinol and poloxamer additive amount and adding proportion therebetween there is no a special limitation, it is every can be with
Realize that the suitable additive amount of the object of the invention belongs to protection scope of the present invention.
Inventor has found that the additive amount of 4- (1- phenethyls) -1,3- benzenediols is preferably less than 5wt%.Poloxamer adds
Ratio is added to be preferably less than 15wt%.The weight percent of 4- (1- phenethyls)-Resorcinols and poloxamer is preferably low
In 1:8.It should be noted that when also added other cosolvents in formula, the additive amount of poloxamer can be according to the present invention
Inventive principle and goal of the invention be adjusted correspondingly.
Preparation method
It should be noted that the preparation method of the water-soluble whitening formula of the present invention is for preparation condition, step and each
The operating time of step is not particularly limited, all suitable preparation conditions that can be achieved on the object of the invention, step and each step
The rapid operating time belongs to protection scope of the present invention.
Preferably operating procedure is：Step 1：Poloxamer is added to the water, stirs to solution and clarifies；Step 2：It adds in
4- (1- phenethyls)-Resorcinol is stirred to solution and is clarified；Step 3：Add in other components.
Technical scheme of the present invention is illustrated below in conjunction with embodiment, the implementation condition used in embodiment can basis
Concrete condition does further adjustment.Following embodiment, the implementation condition being not specified is usually the condition in routine experiment, if not marking
Note is all then to use grade product.
Embodiment
Embodiment 1：4- (1- phenethyls) -1,3- benzenediol whitening and moistening skin essence
Using formula as below and operation, 4- (1- phenethyls)-Resorcinol whitening and moistening skin essence is prepared.Formula：
Table 1
Preparation method：
1) 80g poloxamers are slowly added into 748ml water, stirring is until solution becomes clarification；
2) 4- (1- phenethyls)-Resorcinol of 10g is added in, stirring is until liquid becomes clarification；
3) 1,3-BDO 30g, glycerine 50g, beta glucan 50g, trehalose 10g, beet are sequentially added to above-mentioned solution
Alkali 10g, parahydroxyacet-ophenone 5g, hexylene glycol 5g, carnosine 2g obtain colourless uniform 4- (1- phenethyls)-Resorcinol U.S.
White and moist skin essence.
Embodiment 2：4- (1- phenethyls) -1,3- benzenediol whitening and moistening skin facial mask liquids
Using formula as below and operation, 4- (1- phenethyls)-Resorcinol whitening and moistening skin essence is prepared.Formula：
Table 2
Colourless uniform 4- (1- phenethyls) -1,3- benzenediol whitenings are obtained using operating procedure same as Example 1
Moisturizing essence facial mask liquid.
Embodiment 3：4- (1- phenethyls) -1,3- benzenediol whitening and moistening skin gels
Using following composite formula and operation, 4- (1- phenethyls)-Resorcinol whitening and moistening skin gel is prepared.
Formula：
Table 3
Colourless uniform 4- (1- phenethyls) -1,3- benzenediol whitenings are obtained using operating procedure same as Example 1
Moisturizing essence.
Stability test, each group are carried out to 4- (1- the phenethyls)-Resorcinol whitening preparation prepared in embodiment 1-3
Preparation is all kept in dark place.Statistical experiment result such as the following table 4.Table 4 the results show that 4- prepared in accordance with the present invention (1- phenethyls)-
Resorcinol water solubility whitening formula has prominent stability, and after the storage period by the long period, solution remains to protect
Water white transparency state is held, whitening active ingredients 4- (1- phenethyls)-Resorcinol is stablized, undecomposed discoloration.
Table 4
* 3 hours observe and record after restoring to room temperature
Embodiment 4：Poloxamer is to the contrast experiment of 4- (1- phenethyls) -1,3- benzenediol solubilization-aid effects
In addition to cosolvent composition is different, experimental group 1-4 includes the component of ratio same as below in the present embodiment：0.5%
The 377 of content, 2% 1,2- pentanediols, 0.5% parahydroxyacet-ophenone.The situation of each experimental group addition cosolvent and corresponding
Technique effect such as the following table 5.Table 5 shows that, compared to common surfactant, poloxamer is to 4- (1- phenethyls) -1,3-
Benzenediol has prominent solubilizing effect.
Table 5
Although various embodiments have been described in detail above, those skilled in the art are not it is appreciated that the various inclined
Under the premise of from the content of present invention, various replacements and/or equivalent embodiment can substitute the specific of above-described embodiment and drape over one's shoulders
Dew.This application is intended to cover any modifications and variations for including each embodiment to being discussed.
Claims (30)
1. a kind of water solubility whitening formula, including following components：
4- (1- phenethyls) -1,3- benzenediols；
Poloxamer；
Wherein cosolvent of the poloxamer as 4- (1- phenethyls) -1,3- benzenediols.
2. water solubility whitening formula as described in claim 1, the whitening formula further includes moisturizer, skin sense conditioning agent, prevents
One or more of rotten system.
3. water solubility whitening formula as described in claim 1, the whitening formula further include other cosolvents.
4. water solubility whitening formula as described in claim 1, the whitening formula further include other whitening active compositions.
5. water solubility whitening formula as described in claim 1, the adding proportion of 4- (1- the phenethyls)-Resorcinol are low
In 5wt%.
6. water solubility whitening formula as described in claim 1, the adding proportion of the poloxamer are less than 15wt%.
7. water solubility whitening formula as described in claim 1,4- (1- the phenethyls)-Resorcinols and poloxamer
The ratio between mass percent is less than 1:8.
8. water solubility whitening formula as claimed in claim 2, the adding proportion of the moisturizer are less than 30wt%.
9. water solubility whitening formula as claimed in claim 2, the adding proportion of the skin sense conditioning agent are less than 20wt%.
10. water solubility whitening formula as claimed in claim 2, the adding proportion of the protective system are less than 10wt%.
11. water solubility whitening formula as claimed in claim 8, wherein the moisturizer is selected from glycerine, 1,3-BDO, the third two
The polysaccharides such as the polyalcohols such as alcohol, pentanediol, hexylene glycol, sorbierite, amides, trehalose, glucose/glucose esters, fructose,
Natural moisturizing factor, glycine betaine, polyethylene glycols, panthenol, niacinamide, the shells such as urea, allantoin, lactic acid/sodium lactate, Anjidew NL50
One or more of glycan class.
12. water solubility whitening formula as claimed in claim 9, wherein the skin sense conditioning agent be selected from glucan, hyaluronic acid/
One or more of Sodium Hyaluronate, Pulan sugar, sodium alginate, xanthans, glucose, trehalose, fructose, maltose.
13. water solubility whitening formula as claimed in claim 10, wherein the protective system is selected from parahydroxyacet-ophenone, sorb
Acid/potassium sorbate, Phenoxyethanol, parabens, polyalcohols, Chlorphenesin, glycerol caprylate, dehydroactic acid and
One in its esters, salicylic acid/sodium salicylate, benzoic acid, iodine propilolic alcohol butyl mephenesin Carbamate, the smooth caprylate of sorb, anisic acid
Kind is several.
14. water solubility whitening formula as described in claim 1, the whitening formula are aqueous solution or gel.
15. a kind of purposes of the water-soluble whitening formula described in claim 1-14, the whitening formula be used to prepare facial mask liquid,
Lotion, essence.
A kind of 16. method for preparing water-soluble whitening formula described in claim 1, which is characterized in that made using poloxamer
For cosolvent, 4- (1- phenethyls)-Resorcinol is dissolved in the water.
17. the preparation method of water solubility whitening formula as claimed in claim 16, which is characterized in that include the following steps：
Step 1：Poloxamer is added to the water, stirs to solution and clarifies；
Step 2：4- (1- phenethyls)-Resorcinol is added in, stirs to solution and clarifies；
Step 3：Add in other components.
18. the preparation method of water solubility whitening formula as claimed in claim 16, which is characterized in that 4- (the 1- benzene second
Base) -1,3- benzenediols adding proportion be less than 5wt%.
19. the preparation method of water solubility whitening formula as claimed in claim 16, which is characterized in that the poloxamer adds
Ratio is added to be less than 15wt%.
20. the preparation method of water solubility whitening formula as claimed in claim 16, which is characterized in that 4- (the 1- benzene second
Base) -1,3- benzenediols and the mass percent of poloxamer in formula be less than 1:8.
21. the preparation method of water solubility whitening formula as claimed in claim 16, the whitening formula further include moisturizer, skin
Feel one or more of conditioning agent, protective system.
22. the preparation method of water solubility whitening formula as claimed in claim 21, wherein the moisturizer is selected from glycerine, 1,3-
The polyalcohols such as butanediol, propylene glycol, pentanediol, hexylene glycol, sorbierite, amides, trehalose, glucose/glucose esters, fruit
The polysaccharides such as sugar, it is the natural moisturizing factor such as urea, allantoin, lactic acid/sodium lactate, Anjidew NL50, glycine betaine, polyethylene glycols, general
One or more of alcohol, niacinamide, chitosan class.
23. the preparation method of water solubility whitening formula as claimed in claim 21, wherein the skin sense conditioning agent gathers selected from Portugal
One in sugar, hyaluronic acid/Sodium Hyaluronate, Pulan sugar, sodium alginate, xanthans, glucose, trehalose, fructose, maltose
Kind is several.
24. the preparation method of water solubility whitening formula as claimed in claim 21, wherein the protective system is selected to hydroxyl
Acetophenone, sorbic acid/potassium sorbate, Phenoxyethanol, parabens, polyalcohols, Chlorphenesin, glycerine octanoic acid
Ester, dehydroactic acid and its esters, salicylic acid/sodium salicylate, benzoic acid, iodine propilolic alcohol butyl mephenesin Carbamate, the smooth caprylate of sorb,
One or more of anisic acid.
25. the preparation method of water solubility whitening formula as claimed in claim 22, the adding proportion of the moisturizer are less than
30wt%.
26. the preparation method of water solubility whitening formula as claimed in claim 23, the adding proportion of the skin sense conditioning agent are low
In 20wt%.
27. the preparation method of water solubility whitening formula as claimed in claim 24, the adding proportion of the protective system are less than
10wt%.
28. the preparation method of water solubility whitening formula as claimed in claim 16, the whitening formula further include other hydrotropies
Agent.
29. the preparation method of water solubility whitening formula as claimed in claim 16, which is characterized in that the whitening formula being prepared into
For aqueous solution or gel.
30. the preparation method of water solubility whitening formula as claimed in claim 16, which is characterized in that the whitening formula is used for
Prepare facial mask liquid, lotion, essence.
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| CN113057905A (en) * | 2021-04-15 | 2021-07-02 | 广州樊文花化妆品有限公司 | Whitening composition and preparation method and application thereof |
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