CN108186811A - Treat the drug of cholecystitis - Google Patents
Treat the drug of cholecystitis Download PDFInfo
- Publication number
- CN108186811A CN108186811A CN201810115409.6A CN201810115409A CN108186811A CN 108186811 A CN108186811 A CN 108186811A CN 201810115409 A CN201810115409 A CN 201810115409A CN 108186811 A CN108186811 A CN 108186811A
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- CN
- China
- Prior art keywords
- drug
- cholecystitis
- desmodium
- gizzard
- chicken
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The drug of present invention treatment cholecystitis, by weight including desmodium 1~3, the membrane of a chicken's gizzard 2~4, whiteflower violet herb with root 4~6.Clearing heat and detoxicating, regulating qi-flowing for relieving pain of the invention and good effect, quick, healing success rate is high, at low cost, convenient to take.
Description
Technical field：
The present invention relates to a kind of drugs for treating cholecystitis.
Background technology：
The living standard of modern is higher and higher.With the improvement of living standards, people intake to gall-bladder fat nuisance
It is more and more, so cholecystitis is also more and more and tends to rejuvenation.
The drug for the treatment of cholecystitis mainly carries out anti-inflammatory analgetic using antibiolics at present.But antibiotic medicine is to human body
Injury be undisputable fact.Most serious person even excises one's gallbladder, and has not only aggravated financial burden but also painful.Many patients are willing to take
Use Chinese medicine.But it produces little effect for the state of an illness compared with the general Chinese medicine of severe one or Chinese patent drug.
In order to overcome the above shortcomings, it is an object of the present invention to provide it is a kind of it is clearing heat and detoxicating, regulating qi-flowing for relieving pain, good effect, take effect
Soon, the drug of high, at low cost, the convenient to take treatment cholecystitis of success rate is cured.
The object of the present invention is achieved like this：
The drug of present invention treatment cholecystitis, by weight including following components：
Desmodium 1~3,
The membrane of a chicken's gizzard 2~4,
Whiteflower violet herb with root 4~6.
The drug of above-mentioned treatment cholecystitis, by weight including following components：
Desmodium 2,
The membrane of a chicken's gizzard 3,
Whiteflower violet herb with root 5.
The drug of above-mentioned treatment cholecystitis, by weight including following components：
Desmodium 1~3,
The membrane of a chicken's gizzard 2~4,
Whiteflower violet herb with root 4~6,
Oriental wormwood 0.5~1.5,
The dried immature fruit of citron orange 0.5~1.5,
Radix Glycyrrhizae 0.2~0.8.
The drug of above-mentioned treatment cholecystitis, by weight including following components：
Desmodium 2,
The membrane of a chicken's gizzard 3,
Whiteflower violet herb with root 5,
Oriental wormwood 1,
The dried immature fruit of citron orange 1,
Radix Glycyrrhizae 0.5.
Desmodium nature and flavor toil, cool in drug of the present invention, there is the function of heat-clearing, diuresis, antibechic, detumescence, removing toxic substances, can Yellow River harnessing
Subcutaneous ulcer, oedema, vesical calculus, lung pain, rheumatalgia, eczema etc.；The membrane of a chicken's gizzard nature and flavor are sweet, put down, enter spleen, stomach, control stagnant, strengthening the spleen and stomach
Function, control dyspepsia turgor, vomiting gastric disorder causing nausea, infantile malnutrition due to digestive disturbances or intestinalparasites, quench one's thirst, lose drown etc.；Whiteflower violet herb with root is clearing heat and detoxicating, expelling wind and removing dampness, eliminating stasis to subdue swelling,
Warming spleen and stomach for dispelling cold, Xie Yu analgesics；It is oriental wormwood nature and flavor toil, cool, there is the function of clearing heat secreting bile；Dried immature fruit of citron orange taste bitter and cold has relieving stagnant Qi, dissipates naevus,
Rush down phlegm, disperse accumulation function, control chest and abdomen swelling and pain, pectoralgia, oedema etc..
The drug of present invention treatment cholecystitis can dispensing in proportion, pulvis is made.It takes with warm water.Patient is taking
With rear, as long as avoiding pungent food in one month, greasy food, can cure.
Drug of the present invention has the function of clearing heat and detoxicating, regulating qi-flowing for relieving pain, dissipating bind disperse accumulation, and treatment cholecystitis is quick, cures
Success rate is high, and at low cost, convenient to take, good effect does not recur.Clinical observation 138, total effective rate 100%.Lee's ××：Now
60 years old, male, suffered from 1989 gall stone cholecystitis, symptom is pain, be reflected into vest pain, egg, oil cannot be eaten
The food of fat weight.After taking drug of the present invention, symptom disappears, fully recovers after ten days, does not recur so far.Qiu's ××：66 years old now,
Women suffered from calculous cholecystitis in 2003, pain often with vomiting phenomena such as, after taking drug of the present invention, fully recovered, so far
It does not recur.Dong's ××：49 years old now, women suffered from cholecystitis in 2016.Symptom disappears after taking drug of the present invention, does not recur.
Specific embodiment：
Embodiment 1：
The present embodiment 1 treats the drug of cholecystitis, by weight including following components：
Desmodium 2,
The membrane of a chicken's gizzard 3,
Whiteflower violet herb with root 5.
Embodiment 2：
The present embodiment 2 treats the drug of cholecystitis, by weight including following components：
Desmodium 2,
The membrane of a chicken's gizzard 3,
Whiteflower violet herb with root 5,
Oriental wormwood 1,
The dried immature fruit of citron orange 1,
Radix Glycyrrhizae 0.5.
Embodiment 3：
The present embodiment 3 treats the drug of cholecystitis, by weight including following components：
Desmodium 1,
The membrane of a chicken's gizzard 2,
Whiteflower violet herb with root 4,
Oriental wormwood 0.5,
The dried immature fruit of citron orange 0.5,
Radix Glycyrrhizae 0.2.
Embodiment 4：
The present embodiment 4 treats the drug of cholecystitis, by weight including following components：
Desmodium 3,
The membrane of a chicken's gizzard 4,
Whiteflower violet herb with root 6,
Oriental wormwood 1.5,
The dried immature fruit of citron orange 1.5,
Radix Glycyrrhizae 0.8.
It is as follows that the applicant entrusts certain bio tech ltd to make curative effect evaluation record to drug of the present invention：
Purpose studies the therapeutic effect that drug Chinese medicine powder of the present invention causes bacterium infection globefish cholecystitis, its treatment of Primary Study
Cholecystitis mechanism, to provide experimental basis for its follow-up research and development and clinical promotion and application.
Method：Take 3~4 monthly age male guinea pigs, 250 ± 300g, 48, totally 6 groups, every group 8.It is divided into：Blank control group,
Model group, positive drug group, treats high dose group, treats middle dose group and treats low dose group.In addition to blank group in equal gall-bladder
Escherichia Coli Injection establishes acute cholecystitis guinea pig model.Start to be administered after model success, blank control group is given birth to model gavage
Brine is managed, positive drug group gives XIAOYAN LIDAN PIAN 0.35g/kg, 20 g/kg of Chinese medicine high dose, Chinese medicine middle dosage 10g/kg, in
After medicine low dosage 5g/kg, successive administration 21d, detection：1. gall-bladder and liver weight count liver index and gall-bladder index；2. gall-bladder
And liver pathomorphology inspection；3. peripheral leukocytes, neutrophil leucocyte；4. ELISA detect TNF-α in serum and bile,
IL-6, IL-15, COX-2, bile acid levels；Full-automatic blood system analyzer detection bile total bilirubin, bilirubin direct.5. it adopts
The MIC and MBC of the Chinese medicine compound prescription pulvis are detected with micromethod and two times of methods.
As a result：After Chinese medicine powder treatment, cavy weight is compared with model group weight gain（P ＜ 0.05, P ＜ 0.01）, liver index
It is reduced with gall-bladder index, pathological examination shows that cavy inflammation improves；Blood plasma leucocyte and neutrophil numbers reduce（P ＜
0.05, P ＜ 0.01）.Chinese medicine powder group is compared with model group, TNF-α, IL-6, IL-15, COX- in bile and serum
2nd, bile acid levels are substantially reduced（P ＜ 0.05, P ＜ 0.01）, total bilirubin and bilirubin direct in bile also significantly reduce
（P ＜ 0.01）.The Chinese medicine compound prescription pulvis is 25mg/mL to the MIC of Escherichia coli, and MBC is 100 mg/mL.
Conclusion：The Chinese medicine compound prescription can mitigate the inflammatory reaction that Escherichia coli cause Guinea-pig Gallbladder inflammation, and mechanism is under
It adjusts TNF-α, IL-6, IL-15, COX-2, total bilirubin, bilirubin direct and bile acid levels regulation and control inflammatory reaction, improve
Liver and gallbladder tissue damage and with certain fungistatic effect, play drug action jointly.
Above-described embodiment is that the above of the present invention is further described, but this should not be interpreted as in the present invention
The range for stating theme is only limitted to above-described embodiment.It is all to be all belonged to the scope of the present invention based on the technology that the above is realized.
Claims (4)
1. the drug of cholecystitis is treated, by weight including following components：
Desmodium 1~3,
The membrane of a chicken's gizzard 2~4,
Whiteflower violet herb with root 4~6.
2. the drug for the treatment of cholecystitis according to claim 1, it is characterised in that by weight including following components：
Desmodium 2,
The membrane of a chicken's gizzard 3,
Whiteflower violet herb with root 5.
3. the drug for the treatment of cholecystitis according to claim 1, it is characterised in that by weight including following components：
Desmodium 1~3,
The membrane of a chicken's gizzard 2~4,
Whiteflower violet herb with root 4~6,
Oriental wormwood 0.5~1.5,
The dried immature fruit of citron orange 0.5~1.5,
Radix Glycyrrhizae 0.2~0.8.
4. the drug for the treatment of cholecystitis according to claim 3, it is characterised in that by weight including following components：
Desmodium 2,
The membrane of a chicken's gizzard 3,
Whiteflower violet herb with root 5,
Oriental wormwood 1,
The dried immature fruit of citron orange 1,
Radix Glycyrrhizae 0.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810115409.6A CN108186811A (en) | 2018-02-06 | 2018-02-06 | Treat the drug of cholecystitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810115409.6A CN108186811A (en) | 2018-02-06 | 2018-02-06 | Treat the drug of cholecystitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108186811A true CN108186811A (en) | 2018-06-22 |
Family
ID=62592497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810115409.6A Pending CN108186811A (en) | 2018-02-06 | 2018-02-06 | Treat the drug of cholecystitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108186811A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997035566A1 (en) * | 1996-03-25 | 1997-10-02 | Washington University | Inhibition of nitric oxide formation in acute and chronic inflammation |
| CN102370949A (en) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | Chinese medicinal compound preparation for treating cholecystitis and preparation method thereof |
-
2018
- 2018-02-06 CN CN201810115409.6A patent/CN108186811A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997035566A1 (en) * | 1996-03-25 | 1997-10-02 | Washington University | Inhibition of nitric oxide formation in acute and chronic inflammation |
| CN102370949A (en) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | Chinese medicinal compound preparation for treating cholecystitis and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘向津: "中医药治疗慢性胆囊炎方剂用药规律分析", 《天津中医药》 * |
| 王仁: "《哈萨克药志第3册》", 31 July 2010, 新疆科学技术出版社 * |
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|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180622 |