CN108186786A - Prevent and treat the preparation method of pig blue-ear disease preparation - Google Patents
Prevent and treat the preparation method of pig blue-ear disease preparation Download PDFInfo
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- CN108186786A CN108186786A CN201810045277.4A CN201810045277A CN108186786A CN 108186786 A CN108186786 A CN 108186786A CN 201810045277 A CN201810045277 A CN 201810045277A CN 108186786 A CN108186786 A CN 108186786A
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- 208000032625 disorder of ear Diseases 0.000 title claims abstract description 22
- 238000005238 degreasing Methods 0.000 claims abstract description 27
- 238000001556 precipitation Methods 0.000 claims abstract description 13
- 238000000926 separation method Methods 0.000 claims abstract description 8
- 238000001914 filtration Methods 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 47
- 241001061264 Astragalus Species 0.000 claims description 30
- 235000006533 astragalus Nutrition 0.000 claims description 30
- 235000019441 ethanol Nutrition 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000000706 filtrate Substances 0.000 claims description 19
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- 239000012141 concentrate Substances 0.000 claims description 5
- ZDKZHVNKFOXMND-UHFFFAOYSA-N epinepetalactone Chemical compound O=C1OC=C(C)C2C1C(C)CC2 ZDKZHVNKFOXMND-UHFFFAOYSA-N 0.000 claims description 5
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- 238000001291 vacuum drying Methods 0.000 claims description 3
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/315—Isatis, e.g. Dyer's woad
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Abstract
The preparation method of pig blue-ear disease preparation is prevented and treated, is obtained, had the beneficial effect that by degreasing, filtering, precipitation and separation, concentration proportioning：The present invention prepares the preparation method of prevention and treatment pig blue-ear disease preparation, prepare safe and feasible, it is worth with very strong medical applications, obtained preparation for treating is with obvious effects, Small side effects, the level of complement that can enhance carcass, enhance anti-oxidant and disease resistance, and epidemic disease symptom can be alleviated, impaired body is made to restore as early as possible, it can promote the growth of livestock and poultry simultaneously, improve animal products quality, moreover it is possible to effectively prevent livestock and poultry, reduce incidence.
Description
Technical field
The present invention relates to field of medicine preparation, more particularly, to adding for the preparation method for preventing and treating pig blue-ear disease preparation
Work technology.
Background technology
Pig high-pathogenicity blue ear disease is a kind of infectiousness disease caused by infecting porcine reproductive and respiratory syndrome virus
Disease.At present, mainly the disease easily occurs for the poor small-sized pig farm of feeding and management condition and decentralized household, often breathes and breeds
System infects, and breeding difficulty occurs for sow, and dead, bred pigs infection breathing problem easily occurs before weaned piglet, should
Disease can fast propagation, it is easily dead, it is necessary to be subject to prevention and control.
Live pig is that pig blue-ear disease uniquely infects and there are the natural reservoir (of bird flu viruses) of manifest symptom, either piglet, brood sow, public affairs
Pig or the live pig at any age, pig blue-ear disease can be infected, and difference is only that the Symptoms of growing and fattening pigs are milder, and
Piglet, brood sow, boar especially piglet and the disease symptom of gestational period sow are more serious.Air, contact and body fluid
It is the route of transmission of pig blue-ear disease, vertical transmission can be realized by placenta pig blue-ear disease；Viruliferous rehabilitation pig is taken with passing
Dye source virus is major source of infection.In addition, whole year is the morbidity season of pig blue-ear disease, but wet season is more conducive to virus
Breeding, incidence higher.
The prior art such as Authorization Notice No. is the Chinese invention patent of CN103479786B, disclose it is a kind of for preventing and
The Chinese medicine composition of highly pathogenic PRRS is treated, belongs to field of traditional Chinese veterinary.It is characterized in that with catnip oil, Radix Isatidis, rhizome of cyrtomium, phoenix
Eye grass, gypsum, Radix Rehmanniae, Echinacea, cape jasmine match according to certain proportion, by Hydrolysis kinetics, pharmaceutical adjunct are added to make according to a conventional method
Into corresponding preparation.The invention has significant in efficacy, mark using this Chinese medicine composition to the treatment of highly pathogenic PRRS
The advantages that this is simultaneous to control, and cure rate is high, has no toxic side effect, and uneasy to recur, no poisoning is at low cost, sorrow of the meat without commodity inspection, but it is practical
The slowly effect in.
Invention content
Safe and feasible is prepared the purpose of the present invention is to provide a kind of, it is convenient to prepare, and there are very strong medical applications to be worth
Prevention and treatment pig blue-ear disease preparation preparation method.
The problem of present invention in above-mentioned technology for mentioning, the technical solution taken is：The pig blue-ear disease system of prevention and treatment
The preparation method of agent, including degreasing, slightly carry, precipitation and separation, concentration proportioning obtain, the specific steps are：
Degreasing：It weighs 15-20 parts of Milkvetch Root coarse powder, adds in alcohol reflux degreasing, concentration of alcohol 92-98%, when degreasing is a length of
The w/v of 2-2.5h, Milkvetch Root coarse powder and ethyl alcohol is 1g:4 ~ 6ml, by adding ethyl alcohol in Milkvetch Root coarse powder
Flow back degreasing, removes the lipid in radix astragali coarse powder, improves the DNA purity of astragalus polyose.
Slightly carry：The 1-3 times of distilled water measured is added in medicinal material residue after degreasing, 2-3h is extracted at a temperature of 60-80 DEG C, is taken advantage of
Heat is filtered with absorbent cotton, merging filtrate.It is extracted by adding in water in the medicinal material residue after degreasing, melts the ingredient in medicinal material
Enter in water, residue is being filtered with absorbent cotton, is obtaining the filtrate containing astragalus polyose.
Precipitation and separation：3-5 times is added in after above-mentioned filtrate is concentrated and measures anhydrous solvent, and 4-9 DEG C stands overnight, 3200-
3500r/min centrifuges 6-10min, collects precipitation, adds in ethyl alcohol and washes twice, 56-65 DEG C of vacuum drying, up to brownish-yellow powder
The thick astragalus polyose of shape.By adding in anhydrous solvent in filtrate, by being collected into sediment after dissolving, standing, further carry
The high purity of extraction polysaccharide, then be dried in vacuo after clean sediment with ethyl alcohol and obtain astragalus polyose.
Concentration proportioning：Add 5-8 times to measure water, decoct 30-40 minutes, add 30-40 parts of Radix Isatidis, 20-30 parts of rhizome of cyrtomium, phoenix
20-30 parts of grass of eye, 20-30 parts of Radix Rehmanniae, 20-30 parts of Echinacea, 20-30 parts of cape jasmine plus 9-12 times measure water decoction 2-5 times, every time
Add decoction 1-1.5 hours, filtration, merging filtrate, relative density is the concentrate of 1-1.3 when being concentrated into 55-65 DEG C, adds in schizonepeta
3-5 parts of the astragalus polyose of 0.5-0.8 parts oily, 0.01-0.04 parts of sebacic acid dibutylester and said extracted is uniformly mixed, phase is made
Answer preparation.The preparation being prepared by adding above-mentioned medicinal material has antipyretic, antibacterial, anti-inflammatory, antiviral efficacy, adds certain herbaceous plants with big flowers two
Sour dibutylester compound, strengthens stimulation of the astragalus polyose ingredient to macrophage and T lymphocytes, inducing cell because
Son accelerates the generation of cell medium, and animal body is made to generate endogenous interferon, so as to enhance carcass resistance infection, prevents from raiseeing
Avian disease reduces livestock and poultry incidence, while can also promote the growth of livestock and poultry, improve animal products quality.
Preferably, anhydrous solvent is ethyl alcohol, and a concentration of 4-5%, pH 10-12, extraction time 80-90min, extraction
90-100 DEG C of temperature.By adding ethyl alcohol anhydrous solvent so that it can destroy the integrality of cell membrane, the penetrating of cell membrane is improved
Property so as to dissolve phytochrome and medicinal ingredient therein, improves the DNA purity of medicinal ingredient.
Compared with prior art, the advantage of the invention is that：The present invention prepares the system of prevention and treatment pig blue-ear disease preparation
Preparation Method prepares safe and feasible, and there are very strong medical applications to be worth, and obtained preparation for treating is with obvious effects, Small side effects, energy
Enhance the level of complement of carcass, enhance anti-oxidant and disease resistance, and epidemic disease symptom can be alleviated, impaired body is made to restore as early as possible,
It can promote the growth of livestock and poultry simultaneously, improve animal products quality, moreover it is possible to effectively prevent livestock and poultry, reduce incidence.
Specific embodiment
The present invention program is described further below by embodiment：
Embodiment 1：
Prevent and treat pig blue-ear disease preparation preparation method, by degreasing, slightly carry, precipitation and separation, concentration match obtain, specifically
Step is：
1）Degreasing：15-20 parts of Milkvetch Root coarse powder is weighed, adds in alcohol reflux degreasing, concentration of alcohol 92-98%, degreasing duration
For 2-2.5h, the w/v of Milkvetch Root coarse powder and ethyl alcohol is 1g:4 ~ 6ml, by adding second in Milkvetch Root coarse powder
Alcohol reflux degreasing removes the lipid in radix astragali coarse powder, improves the DNA purity of astragalus polyose；
2）Slightly carry：The 1-3 times of distilled water measured is added in medicinal material residue after degreasing, 2-3h is extracted at a temperature of 60-80 DEG C, while hot
It is filtered with absorbent cotton, merging filtrate.It is extracted by adding in water in the medicinal material residue after degreasing, incorporates the ingredient in medicinal material
In water, residue is being filtered with absorbent cotton, is obtaining the filtrate containing astragalus polyose；
3）Precipitation and separation：3-5 times is added in after above-mentioned filtrate is concentrated and measures anhydrous solvent, and 4-9 DEG C stands overnight, 3200-3500r/
Min centrifuges 6-10min, collects precipitation, adds in ethyl alcohol and washes twice, and 56-65 DEG C of vacuum drying is slightly yellow up to brownish-yellow powder shape
Astragalus polysaccharides.By adding in anhydrous solvent in filtrate, by being collected into sediment after dissolving, standing, further improve and carry
The purity of polysaccharide is taken, then is dried in vacuo after cleaning sediment with ethyl alcohol and obtains astragalus polyose；
4）Concentration proportioning：Add 5-8 times to measure water, decoct 30-40 minutes, add 30-40 parts of Radix Isatidis, 20-30 parts of rhizome of cyrtomium, phoenix eyes
20-30 parts careless, 20-30 parts of Radix Rehmanniae, 20-30 parts of Echinacea, 20-30 parts of cape jasmine plus 9-12 times are measured water and are decocted 2-5 times, add every time
It decocts 1-1.5 hours, filtration, merging filtrate, relative density is the concentrate of 1-1.3 when being concentrated into 55-65 DEG C, adds in catnip oil
0.5-0.8 parts, 3-5 parts of the astragalus polyose of 0.01-0.04 parts of sebacic acid dibutylester and said extracted, are uniformly mixed, and are made corresponding
Preparation.The preparation being prepared by adding above-mentioned medicinal material has antipyretic, antibacterial, anti-inflammatory, antiviral efficacy, adds sebacic acid
Dibutylester compound, strengthens stimulation of the astragalus polyose ingredient to macrophage and T lymphocytes, inducing cytokine,
The generation of cell medium is accelerated, animal body is made to generate endogenous interferon, so as to enhance carcass resistance infection, prevents livestock and poultry disease
Disease reduces livestock and poultry incidence, while can also promote the growth of livestock and poultry, improve animal products quality.
Anhydrous solvent is ethyl alcohol, a concentration of 4-5%, pH 10-12, extraction time 80-90min, Extracting temperature 90-100
℃.By adding ethyl alcohol anhydrous solvent so that it can destroy the integrality of cell membrane, membrane passage is improved, so as to come
Phytochrome and medicinal ingredient therein are dissolved, improves the DNA purity of medicinal ingredient.
Embodiment 2：
The preparation method of pig blue-ear disease preparation is prevented and treated, preparation method includes the following steps：
1）Degreasing：It weighs 18 parts of Milkvetch Root coarse powder, adds in alcohol reflux degreasing, concentration of alcohol 96%, when degreasing is a length of
The w/v of 2.2h, Milkvetch Root coarse powder and ethyl alcohol is 1g:5ml；
2）Slightly carry：The water of 1 times of amount is added in medicinal material residue after degreasing, 1h is extracted at a temperature of 50 DEG C, while hot with absorbent cotton mistake
Filter, merging filtrate；
3）Precipitation and separation：Will above-mentioned filtrate concentration after add in 2 times amount ethyl alcohol, a concentration of 4%, pH 10,90 DEG C of Extracting temperature,
Extraction time 80min, 6 DEG C stand overnight, and 3300r/min centrifugation 5min collect precipitation, add in ethyl alcohol and wash twice, and 56 DEG C true
Sky is dry, up to the thick astragalus polyose of brownish-yellow powder shape；
4）Concentration proportioning：Add 5 times of amount water, decoct 30 minutes, add 30 parts of Radix Isatidis, 20 parts of rhizome of cyrtomium, 20 parts of fruits of Ailanthus altissima, Radix Rehmanniae
20 parts, 20 parts of Echinacea, 20 parts of cape jasmine plus 9 times of amount water decoct 2 times, every time plus decoct 1 hour, filtration, merging filtrate, concentration
To the concentrate that relative density at 55 DEG C is 1, the Huang of 0.5 part of catnip oil, 0.01 part of sebacic acid dibutylester and said extracted is added in
3 parts of astragalus polysaccharides are uniformly mixed, corresponding preparations are made.
Embodiment 3：
The preparation method of pig blue-ear disease preparation is prevented and treated, is included the following steps：
1）Degreasing：It weighs 16 parts of Milkvetch Root coarse powder, adds in alcohol reflux degreasing, concentration of alcohol 92%, a length of 2h during degreasing,
The w/v of Milkvetch Root coarse powder and ethyl alcohol is 1g:6ml；
2）Slightly carry：The distilled water of 1 times of amount is added in medicinal material residue after degreasing, 2h is extracted at a temperature of 60 DEG C, uses degreasing while hot
Cotton is filtered, merging filtrate；
3）Precipitation and separation：Will above-mentioned filtrate concentration after add in 4 times amount ethyl alcohol, a concentration of 5%, pH 12,100 DEG C of Extracting temperature,
Extraction time 90min, 6 DEG C stand overnight, and 3200r/min centrifugation 7min collect precipitation, add in ethyl alcohol and wash twice, and 62 DEG C true
Sky is dry, up to the thick astragalus polyose of brownish-yellow powder shape；
4）Concentration proportioning：Add 8 times of amount water, decoct 40 minutes, add 40 parts of Radix Isatidis, 30 parts of rhizome of cyrtomium, 30 parts of fruits of Ailanthus altissima, Radix Rehmanniae
30 parts, 30 parts of Echinacea, 30 parts of cape jasmine plus 12 times of amount water decoct 4 times, every time plus decoct 1.5 hours, filtration, merging filtrate is dense
Relative density is 1.2 concentrate when being reduced to 60 DEG C, adds in 0.8 part of catnip oil, 0.03 part of sebacic acid dibutylester and said extracted
5 parts of astragalus polyose, be uniformly mixed, corresponding preparations are made.
Routine operation in the operating procedure of the present invention is well known to those skilled in the art, herein without repeating.
Technical scheme of the present invention is described in detail in embodiment described above, it should be understood that the above is only
For specific embodiments of the present invention, it is not intended to restrict the invention, all any modifications made in the spirit of the present invention,
Supplement or similar fashion replacement etc., should all be included in the protection scope of the present invention.
Claims (5)
1. prevent and treat the preparation method of pig blue-ear disease preparation, it is characterised in that：Following steps：
1）Defatting step is：15-20 parts of Milkvetch Root coarse powder is weighed, adds in alcohol reflux degreasing；
2）Slightly putting forward step is：The 1-3 times of water measured is added in medicinal material residue after degreasing to extract, is filtered while hot with absorbent cotton,
Merging filtrate；
3）Precipitation and separation step is：3-5 times is added in after above-mentioned filtrate is concentrated and measures anhydrous solvent, and 4-9 DEG C stands overnight, 3200-
3500r/min centrifuges 6-10min, collects precipitation, adds in ethyl alcohol and washes twice, 56-65 DEG C of vacuum drying, up to brownish-yellow powder
The thick astragalus polyose of shape；
4）Concentration matches step：Add 5-8 times to measure water, decoct 30-40 minutes, add 30-40 parts of Radix Isatidis, rhizome of cyrtomium 20-30
Part, 20-30 parts of fruits of Ailanthus altissima, 20-30 parts of Radix Rehmanniae, 20-30 parts of Echinacea, 20-30 parts of cape jasmine plus 9-12 times are measured water and are decocted 2-5 times,
It every time plus decocts 1-1.5 hours, filtration, is concentrated into concentrate after merging filtrate, adds in 0.5-0.8 parts of catnip oil, sebacic acid two
3-5 parts of 0.01-0.04 parts of fourth fat and the astragalus polyose of said extracted are uniformly mixed, corresponding preparations are made.
2. according to the preparation method for preventing and treating pig blue-ear disease preparation according to claim 1, it is characterised in that：The step
Concentration of alcohol in rapid 1 is 92-98%, a length of 2-2.5h during degreasing, and the w/v of Milkvetch Root coarse powder and ethyl alcohol is 1g:4
~6ml。
3. according to the preparation method for preventing and treating pig blue-ear disease preparation according to claim 1, it is characterised in that：The step
The water added in rapid 2 is distilled water, and Extracting temperature is 60-80 DEG C, extraction duration 2-3h.
4. the preparation method of pig blue-ear disease preparation is prevented and treated according to claim 1, it is characterised in that：The step 3
In anhydrous solvent for ethyl alcohol, a concentration of 4-5%, pH 10-12, extraction time 80-90min, 90-100 DEG C of Extracting temperature.
5. according to the preparation method for preventing and treating pig blue-ear disease preparation according to claim 1, it is characterised in that：The step
Thickening temperature is 55-65 DEG C in rapid 4, density 1-1.3.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060032733A (en) * | 2004-10-13 | 2006-04-18 | 알앤엘생명과학주식회사 | Functional composition containing extract of P. vulgaris and Ganoderma lucidum |
| CN101433607A (en) * | 2008-12-12 | 2009-05-20 | 上海中医药大学 | Composition of Chinese medicine extract for treating diabetes |
| CN103479786A (en) * | 2013-09-26 | 2014-01-01 | 青岛农业大学 | Traditional Chinese medicine composition for treating PRRS (Porcine Reproductive and Respiratory Syndrome) and preparation method and application thereof |
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2018
- 2018-01-17 CN CN201810045277.4A patent/CN108186786A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060032733A (en) * | 2004-10-13 | 2006-04-18 | 알앤엘생명과학주식회사 | Functional composition containing extract of P. vulgaris and Ganoderma lucidum |
| CN101433607A (en) * | 2008-12-12 | 2009-05-20 | 上海中医药大学 | Composition of Chinese medicine extract for treating diabetes |
| CN103479786A (en) * | 2013-09-26 | 2014-01-01 | 青岛农业大学 | Traditional Chinese medicine composition for treating PRRS (Porcine Reproductive and Respiratory Syndrome) and preparation method and application thereof |
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