CN108186475A - Whitening and skin-protecting lotion and preparation method thereof - Google Patents
Whitening and skin-protecting lotion and preparation method thereof Download PDFInfo
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- CN108186475A CN108186475A CN201810235252.0A CN201810235252A CN108186475A CN 108186475 A CN108186475 A CN 108186475A CN 201810235252 A CN201810235252 A CN 201810235252A CN 108186475 A CN108186475 A CN 108186475A
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- skin
- whitening
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- protecting lotion
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- 230000003595 spectral effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical compound C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The invention discloses a kind of whitening and skin-protecting lotion and preparation method thereof, including following components by weight percentage：Neohesperidin dihydrochalcone 0.1%~10%, scutelloside 0.1%~10%, turtle turtle pectin 0.1%~5%, turtle turtle essential oil 0.1%~2%, organic solvent 10%~20%, carbomer 0.01%~0.1%, surplus is water.In the component of the whitening and skin-protecting lotion, neohesperidin dihydrochalcone and scutelloside are compounded with above-mentioned weight percent, the active site of tyrosinase can be destroyed, tyrosinase is made to lose the effect to melanin precursor tyrosine, so as to achieve the purpose that inhibit melanin formation.In addition, neohesperidin dihydrochalcone and scutelloside can effectively inhibit 1 gene upregulations of MMP as caused by infrared ray, so as to effectively prevent human skin early ageing.The preparation method of the whitening and skin-protecting lotion, raw material easily obtain, at low cost, and method simply easily realizes industrialized production.
Description
Technical field
The present invention relates to cosmetic technical fields, particularly, are related to a kind of whitening and skin-protecting lotion and preparation method thereof.
Background technology
Skin is one of traditional aesthetic standard of Chinese women in vain, and many women are wished by using functional Skin whitening care cosmetics
To reach whitening effect, whitening product is at home and abroad respectively provided with huge market value, but infrared ray causes MMP-1 bases in human body
Because of up-regulation, MMP-1 is the controlling gene of collagen degrading enzymes, the degradation of collagen be human skin early ageing it is main because
Element.Meanwhile the calmness of melanin can excessively cause the skin problems such as color spot, freckle, affect the skin quality of skin.
Generally acknowledged melanocyte forming process can be indicated briefly as at present：Tyrosine --- DOPA --- DOPA quinone --- DOPA
--- dihydroxy indole --- keto-acid indoles --- melanocyte, the melanocyte of formation is excellent melanocyte or eumelanin, the pigment of skin for pigment
Mainly it is made from it.Since the formation of melanin is occurred mainly in melanocyte, to the melanin shape in melanocyte
Into mechanism research shows that, the formation of melanin is primarily due to include four kinds of enzymes in melanocyte：Tyrosinase, DOPA color
(TRP-1, stabilizes the activity of tyrosinase, and this point is for plain interconvertible enzyme (TRP-2), peroxidase and DI-IICA oxidizing ferment
The difference of the tyrosinase of human body and the tyrosinase of mouse, mushroom etc.), and above-mentioned four kinds of enzymes act on alone or synergistically
Result.If realizing the real whitening of skin, a variety of melanin are formed with the inhibition of enzyme just seems most important.
Above-mentioned various melanin are formed in enzyme, and tyrosinase is a kind of polyphenol oxidase, belong to redox enzymes, enzyme master
It is catalyzed the different reaction of two categories below：Monohydric phenol hydroxylating generates o-dihydroxy compound and adjacent diphenol oxidation generation is adjacent
Diphenylquinone.There is oxygen radical to participate in reaction in the reaction of this two class.Tyrosinase is main speed limit in melanin forming process
Enzyme, the enzymatic activity size decide the quantity that melanin is formed.Therefore, the active site for destroying tyrosinase can reach inhibition
The purpose that melanin is formed.
Invention content
The present invention provides a kind of whitening and skin-protecting lotion and preparation method thereof, to solve when the formation of melanin in skin
The technical issues of blackening of skin quality variation, infrared ray is caused to cause skin early ageing and pigementation.
The technical solution adopted by the present invention is as follows：
A kind of whitening and skin-protecting lotion, including following components by weight percentage：Neohesperidin dihydrochalcone 0.1%
~10%, scutelloside 0.1%~10%, turtle turtle pectin 0.1%~5%, turtle turtle essential oil 0.1%~2%, organic solvent 10%~
20%, carbomer 0.01%~0.1%, surplus is water.
Further, including following components by weight percentage：Neohesperidin dihydrochalcone 0.6%~8%, it is yellow
A kind of reed mentioned in ancient books glycosides 0.1%~5%, turtle turtle pectin 0.5%~5%, turtle turtle essential oil 0.1%~2%, organic solvent 10%~20%, card wave
Nurse 0.01%~0.1%, surplus are water.
Further, flavones in mulberry leaves is further included in whitening and skin-protecting lotion, weight percent is 0.1%~5%.
Further, flavones in mulberry leaves is further included in whitening and skin-protecting lotion, weight percent is 0.1%~3%.
Further, following components by weight percentage is further included in whitening and skin-protecting lotion：Phloretin 0.1%~
5%, polysaccharides 0.1%~5%.
Further, following components by weight percentage is further included in whitening and skin-protecting lotion：Phloretin 0.5%~
5%, polysaccharides 0.1%~3%.
Further, organic solvent is one or more of butanediol, propylene glycol, glycerine, diethylene glycol (DEG).
According to another aspect of the present invention, a kind of preparation method of above-mentioned whitening and skin-protecting lotion is additionally provided, including following
Step：Organic solvent and carbomer are placed in cutter, turtle turtle pectin and water are added in shear history, then adds in new orange peel
Glycosides dihydrochalcone, scutelloside finally add turtle turtle essential oil to get to whitening and skin-protecting lotion.
The invention has the advantages that：
In the component of whitening and skin-protecting lotion provided by the invention, neohesperidin dihydrochalcone and scutelloside compounding can be with
The destructive active site for inhibiting, that is, destroying tyrosinase is generated to tyrosinase, tyrosinase is made to lose to melanin precursor
The effect of tyrosine, so as to achieve the purpose that inhibit melanin formation.Meanwhile neohesperidin dihydrochalcone and scutelloside can
The MMP-1 gene upregulations as caused by infrared ray are effectively inhibited, so as to effectively prevent human skin early ageing.In addition, turtle turtle
The addition of essential oil makes whitening and skin-protecting lotion have stronger antibacterial effect；Turtle turtle pectin is the antidote and prophylactic of heavy metal,
The content of the heavy metal introduced in skin by air, food and other cosmetics can be reduced, is combined and can prolonged with turtle turtle essential oil
Its long antibacterial action and antibacterial period；The solubility of neohesperidin dihydrochalcone and scutelloside in room temperature aqueous solution is limited,
It is easily precipitated and influences whitening effect, the addition of turtle turtle pectin can enhance the stability of whole system, make U.S. of facial treatment milk
White effect further enhances.
The preparation method of whitening and skin-protecting lotion provided by the invention, raw material easily obtains, at low cost, and method is simply easily realized
Industrialized production.The traditional preparation methods of lotion first have to heat system, so as to improve the solubility of each component,
Then system temperature is reduced, then carries out packing allotment.Traditional method not only waste of energy, long preparation period, and heating
During certain destruction can be generated to the active ingredient of each component, so as to influence the whitening effect of lotion.The present invention utilizes
High-speed shearing machine carries out shearing dissolving to each component, avoids the heating process to system, does not have what is destroyed to each component
The loss of the energy is reduced simultaneously, shortens manufacturing cycle.
Other than objects, features and advantages described above, the present invention also has other objects, features and advantages.
The present invention is further detailed explanation below.
Specific embodiment
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the application can phase
Mutually combination.Below in conjunction with embodiment, the present invention will be described in detail.
The preferred embodiment of the present invention provides a kind of whitening and skin-protecting lotion, including by weight percentage with the following group
Point：Neohesperidin dihydrochalcone 0.1%~10%, scutelloside 0.1%~10%, turtle turtle pectin 0.1%~5%, turtle turtle essence
Oil 0.1%~2%, organic solvent 10%~20%, carbomer 0.01%~0.1%, surplus is water.
In the component of above-mentioned whitening and skin-protecting lotion, neohesperidin dihydrochalcone be plant origin flavone compound it
One, at present mainly as sweetener in food industry.It has been investigated that above-mentioned neohesperidin dihydrochalcone is than β-black bearberry
Glycosides, kojic acid and VC have more preferable TYR enzyme inhibition.Neohesperidin dihydrochalcone is a kind of glucosides flavonoids, flavonoids
Compound is a kind of natural materials extracted from plant.Many flavone glycosides are neohesperidins specific to rutaceae
The synthesis initial substance of dihydrochalcone is neohesperidin, and neohesperidin is that Hydrolysis kinetics form in bigarabe.Document shows new orange
Skin glycosides dihydrochalcone is compared with β-ursin, VC and kojic acid, the tyrosinase inhibition rate highest of neohesperidin dihydrochalcone.
Neohesperidin dihydrochalcone approaches the rejection ability that melanin generates and VC and kojic acid, is 3 times of β-ursin, therefore new
Aurantiamarin dihydrochalcone is a kind of novel whitening agent with application potential, main active can be used as to be used for novel whitening
In the exploitation of skin care item.
In the component of above-mentioned whitening and skin-protecting lotion, scutelloside is a kind of flavone compound extracted from Radix Astragali, in vitro
Oxygen radical absorptive capacity method confirms that the antioxidant activity of radix scutellariae is more than vitamin E, is vitamin E class, vitamin c class and Hu Luo
The natural powerful antioxidant of one kind except Bu Su.Scutelloside is not only able to inhibit ascorbic acid and the mouse brain of ferrous sulfate induction thin
Born of the same parents' peroxidatic reaction of lipid, and with reduction using malic acid and glutamic acid as substrate, the cranial nerve oxygen consumption of ADP stimulations, so as to
The peroxidization of its lipid can be reduced.
In the component of above-mentioned whitening and skin-protecting lotion, the extracting method of turtle turtle essential oil is, by being obtained by extraction in bitter citrus immature flower, to extract
Condition is 40 degree, pressure 35Mpa, carbon dioxide flow 20kg/h of temperature, and the bulk density of bitter citrus immature flower is 0.33g/ml, extract
Yield 3.0%~3.3%, the turtle turtle essential oil appearance extracted be light yellow clarifying liquid body, aroma of pure.Turtle turtle essential oil it is main
Active constituent is limonene, and pharmacological evaluation proves that turtle turtle essential oil is a kind of natural bacteriostatic agent, has very strong antibacterial action.
In the component of above-mentioned whitening and skin-protecting lotion, the extracting method of turtle turtle pectin is to take turtle turtle extracting flavonoids slag, adds 10 times
Pure water is measured, PH is adjusted as 1.5~2,85 degree of extraction 2h with citric acid, filters, 2 times amounts of the filtrate concentration for extraction slag, use is anhydrous
It is 55%~60% that ethyl alcohol, which adjusts alcoholic degree, collects precipitation, and vacuum drying crushes to obtain the final product, extracts turtle turtle pectin as white powder.
Turtle turtle pectin is the antidote and prophylactic of a kind of pure natural stabilizer and thickener or heavy metal, can also be extended anti-
The effect of rhzomorph and turtle turtle essential oil proportioning significantly increase the antibacterial ability of turtle turtle essential oil and antibacterial period.
In the component of above-mentioned whitening and skin-protecting lotion, carbomer is emulsifier, can give full play to surfactant wetting,
The effects that dispersion, adherency, stable emulsion products can be made.
In the component of above-mentioned whitening and skin-protecting lotion, neohesperidin dihydrochalcone and scutelloside are answered with above-mentioned weight percent
Match, the destructive active site for inhibiting, that is, destroying tyrosinase can be generated to tyrosinase, tyrosinase is made to lose to black
The effect of plain precursor tyrosine, so as to achieve the purpose that inhibit melanin formation.Meanwhile neohesperidin dihydrochalcone and radix scutellariae
Glycosides can effectively inhibit the MMP-1 gene upregulations as caused by infrared ray, so as to effectively prevent human skin early ageing.Separately
Outside, the addition of turtle turtle essential oil makes whitening and skin-protecting lotion have stronger antibacterial effect；Turtle turtle pectin for heavy metal antidote with
Prophylactic can reduce the content of the heavy metal introduced in skin by air, food and other cosmetics, be combined with turtle turtle essential oil
Its antibacterial action and antibacterial period can be extended；The solubility of neohesperidin dihydrochalcone and scutelloside in room temperature aqueous solution
It is limited, it is easily precipitated and influences whitening effect, the addition of turtle turtle pectin can enhance the stability of whole system, make facial treatment milk
Whitening effect further enhance.
Preferably, above-mentioned whitening and skin-protecting lotion includes following components by weight percentage：Neohesperidin dihydro looks into ear
Ketone 0.6%~8%, scutelloside 0.1%~5%, turtle turtle pectin 0.5%~5%, turtle turtle essential oil 0.1%~2%, organic solvent
10%~20%, carbomer 0.01%~0.1%, surplus is water.It is highly preferred that above-mentioned whitening and skin-protecting lotion is included with weight hundred
Divide the following components than meter：Neohesperidin dihydrochalcone 0.6%~5%, scutelloside 0.1%~1%, turtle turtle pectin 3%~
5%, turtle turtle essential oil 0.1%~2%, organic solvent 10%~20%, carbomer 0.01%~0.1%, surplus is water.
Each component is compounded with above-mentioned preferred weight percent in above-mentioned whitening and skin-protecting lotion, can be preferably to tyrosine
Enzyme generates inhibition, so as to inhibit the formation of melanin；In addition, the optimum ratio of neohesperidin dihydrochalcone and scutelloside, energy
It is enough most effectively to inhibit the MMP-1 gene upregulations as caused by infrared ray, preferably inhibit effect so as to be generated to human skin early ageing
Fruit；Turtle turtle essential oil, turtle turtle pectin optimum ratio make the antibacterial action of above-mentioned facial treatment milk most strong, and reinforcement to the maximum extent
The stability of each component in system, makes whitening effect best.
Preferably, flavones in mulberry leaves is further included in above-mentioned whitening and skin-protecting lotion, weight percent is 0.1%~5%.It is excellent again
Selection of land, weight percent are 0.1%~3%.It is highly preferred that its weight percent is 0.1%~1%.
In the component of above-mentioned whitening and skin-protecting lotion, flavones in mulberry leaves is a kind of flavone compound extracted from mulberry tree, mulberry
Leaf flavones can reduce LPO contents, change GSH-PX levels, so as to reach antioxidant activity by improving SOD activity.It is above-mentioned
The compounding of flavones in mulberry leaves and neohesperidin dihydrochalcone, scutelloside can enhance the energy for the active site for destroying tyrosinase
Power makes tyrosinase lose the enhancing of the effect to melanin precursor tyrosine, so as to enhance the whitening of above-mentioned whitening and skin-protecting lotion
Effect.
Preferably, following components by weight percentage is further included in above-mentioned whitening and skin-protecting lotion：Phloretin 0.1%~
5%, polysaccharides 0.1%~5%.More preferably, by weight percentage following is further included in above-mentioned whitening and skin-protecting lotion
Component：Phloretin 0.5%~5%, polysaccharides 0.1%~3%.It is highly preferred that further included in above-mentioned whitening and skin-protecting lotion with
The following components of weight percent meter：Phloretin 1%~5%, polysaccharides 0.1%~1%.
In the component of above-mentioned whitening and skin-protecting lotion, phloretin is the glucoside member part of phloridzin, by acid hydrolysis from root skin
It is separated in glucoside；Or it is synthesized by corresponding chemical process.Phloretin can inhibit the excessive secretion of sebaceous glands, for controlling
It treats and secretes vigorous type acne；It can inhibit melanocyte activity, there is very strong elimination effect to various skin splash.
In the component of above-mentioned whitening and skin-protecting lotion, polysaccharides is a kind of polysaccharide compound extracted from matrimony vine.Stream
The dermopathic occurrence and development such as row disease data confirmation, acne, atopic dermatitis, polymorphous light eruption, chorionitis, Several Epidermal Tumors
It is related with oxidativestress damage, and polysaccharides can mitigate the oxidativestress damage of cell by its Antioxidation Mechanism, dimension
Hold skin oxidative and antioxidant homeostasis reparation and protection cell.
In the component of above-mentioned whitening and skin-protecting lotion, when phloretin, polysaccharides and flavones in mulberry leaves compound, suppression can be passed through
The biosynthesis of tyrosinase processed or the substrate specificity for replacing tyrosinase, so as to achieve the purpose that inhibit melanin formation.Again
In addition the compounding with neohesperidin dihydrochalcone, scutelloside, five kinds of ingredient combinations use, and thoroughly cut off the source of melanin generation
Head achievees the effect that skin whitening.
Preferably, organic solvent is one or more of butanediol, propylene glycol, glycerine, diethylene glycol (DEG).It is highly preferred that have
Solvent is butanediol.Above-mentioned organic solvent is conducive to the abundant dissolving of each component in whitening and skin-protecting lotion, each in order to play
The synergistic effect of component.Wherein butanediol has splendid moisture-keeping function and dissolubility, and 5 kinds of main components are in the equal energy of butanediol kind
It dissolves well.
Preferably, the water used in above-mentioned whitening and skin-protecting lotion is deionized water, more preferably two level purified water.
According to another aspect of the present invention, the preparation method of above-mentioned whitening and skin-protecting lotion is additionally provided, is included the following steps：
Organic solvent and carbomer are placed in cutter, turtle turtle pectin and water are added in shear history, then adds in neohesperidin two
Hydrogen chalcone, scutelloside finally add turtle turtle essential oil to get to whitening and skin-protecting lotion.Mulberry is further included in whitening and skin-protecting lotion
When leaf flavones, phloretin and polysaccharides component, add in and cut together with neohesperidin dihydrochalcone, scutelloside
It cuts.
The preparation method of above-mentioned whitening and skin-protecting lotion, raw material easily obtains, at low cost, and method simply easily realizes industrial metaplasia
Production.The traditional preparation methods of lotion first have to heat system, so as to improve the solubility of each component, then reduce
System temperature, then carry out packing allotment.Traditional method not only waste of energy, long preparation period, and during heating
Certain destruction can be generated to the active ingredient of each component, so as to influence the whitening effect of lotion.The present invention utilizes high speed shear
Machine carries out shearing dissolving to each component, avoids the heating process to system, is reduced while destruction to each component
The loss of the energy, shortens manufacturing cycle.
Embodiment
Chemical reagent is commercially available in following embodiment.
Embodiment 1
A kind of whitening and skin-protecting lotion, including following components by weight percentage：Neohesperidin dihydrochalcone 2%,
Scutelloside 1%, flavones in mulberry leaves 0.5%, phloretin 3%, polysaccharides 0.5%, butanediol 15%, turtle turtle pectin 5%, turtle turtle essence
Oil 1%, carbomer 0.1%, two level purified water 71.9%.
The preparation method of above-mentioned whitening and skin-protecting lotion is as follows：Butanediol is placed in carbomer in high-speed shearing machine and is cut
It cuts, shear velocity is 15000 revs/min, and two level purified water is slowly added in shear history, after room temperature shears 10min, is slowly added
Enter turtle turtle pectin, then room temperature shearing 10min, then add in neohesperidin dihydrochalcone, scutelloside, flavones in mulberry leaves, phloretin
And polysaccharides, it dissolves after room temperature shearing 20min, finally adds turtle turtle essential oil shearing 10min to get to above-mentioned whitening and skin-protecting
Lotion.
Human skin fibroblast is taken, using Hydrosun 500H IRA equipment, the above-mentioned whitening and skin-protecting after test processes
Suppression of the composition matched in 5 kinds of main components and embodiment 1 in lotion after Infrared irradiation to MMP-1 gene upregulations
It makes and uses.The processing of 5 kinds of main components is as follows：
Scutelloside：The 44.8mmol/ml scutellosides for being dissolved in DMSO are diluted to 10umol/ml, 25umol/ml respectively；
Phloretin：The 50mmol/ml phloretins for being dissolved in DMSO are diluted to 1umol/ml, 5umol/ml, 10umol/ respectively
ml；
Flavones in mulberry leaves：The 50mmol/ml flavones in mulberry leaves for being dissolved in DMSO is diluted to 5umol/ml, 10umol/ml respectively；
Polysaccharides：The 50mmol/ml polysaccharides for being dissolved in DMSO is diluted to 5umol/ml, 10umol/ml respectively；
Neohesperidin dihydrochalcone：The 710mmol/ml neohesperidin dihydrochalcones for being dissolved in DMSO are diluted to respectively
100umol/ml、500umol/ml、1mmol/ml。
The composition matched in embodiment 1：Be dissolved in DMSO 50mmol/ml compositions be diluted to respectively 5umol/ml,
10umol/ml。
Before being tested, human skin fibroblast is cultivated for 24 hours in above-mentioned each ingredient of prescribed concentration, is then used
360J/cm2Infrared radiation for 24 hours, this is infrared to have been shown to inducible gene expression without damaging cell function.Then it extracts
RNA analyzes MMP-1mRNA.Analysis result is as shown in table 1.By analysis result data in table 1 it is found that 5 kinds of main components
And it can inhibit the up-regulation of the MMP-1 genes of infrared photoinduction by the composition that embodiment 1 matches.
The composition of 15 kinds of main components of table and Examples 1 to 5 proportioning is to the inhibiting rate of MMP-1 gene upregulations
Embodiment 2
A kind of whitening and skin-protecting lotion, including following components by weight percentage：Neohesperidin dihydrochalcone 8%,
Scutelloside 5%, flavones in mulberry leaves 0.1%, phloretin 0.1%, polysaccharides 0.1%, butanediol 15%, turtle turtle pectin 5%, turtle turtle
Essential oil 1%, carbomer 0.1%, two level purified water 65.6%.
The preparation method of above-mentioned whitening and skin-protecting lotion is same as Example 1.
The composition matched in embodiment 2 is after Infrared irradiation to the inhibiting effect result of MMP-1 gene upregulations such as table 1
It is shown.
Embodiment 3
A kind of whitening and skin-protecting lotion, including following components by weight percentage：Neohesperidin dihydrochalcone 2%,
Scutelloside 1%, flavones in mulberry leaves 5%, phloretin 5%, polysaccharides 5%, butanediol 15%, turtle turtle pectin 5%, turtle turtle essential oil
2%, carbomer 0.1%, two level purified water 59.9%.
The preparation method of above-mentioned whitening and skin-protecting lotion is same as Example 1.
The composition matched in embodiment 3 is after Infrared irradiation to the inhibiting effect result of MMP-1 gene upregulations such as table 1
It is shown.
Embodiment 4
A kind of whitening and skin-protecting lotion, including following components by weight percentage：Neohesperidin dihydrochalcone 8%,
Scutelloside 5%, flavones in mulberry leaves 3%, phloretin 5%, polysaccharides 3%, butanediol 20%, turtle turtle pectin 5%, turtle turtle essential oil
2%, carbomer 0.1%, two level purified water 48.9%.
The preparation method of above-mentioned whitening and skin-protecting lotion is same as Example 1.
The composition matched in embodiment 4 is after Infrared irradiation to the inhibiting effect result of MMP-1 gene upregulations such as table 1
It is shown.
Embodiment 5
A kind of whitening and skin-protecting lotion, including following components by weight percentage：Neohesperidin dihydrochalcone 10%,
Scutelloside 10%, flavones in mulberry leaves 5%, phloretin 5%, polysaccharides 5%, butanediol 20%, turtle turtle pectin 5%, turtle turtle essential oil
2%, carbomer 0.1%, two level purified water 37.9%.
The preparation method of above-mentioned whitening and skin-protecting lotion is same as Example 1.
The composition matched in embodiment 5 is after Infrared irradiation to the inhibiting effect result of MMP-1 gene upregulations such as table 1
It is shown.
In order to verify the whitening effect of product of the present invention, do following contrast test formula and carry out contrast experiment：
Formula 1：Flavones in mulberry leaves, phloretin, polysaccharides are replaced respectively with the two level purified water of equivalent, the group of other components
Into with the preparation method is the same as that of Example 1.
Formula 2：Neohesperidin dihydrochalcone, scutelloside are replaced respectively with the two level purified water of equivalent, other components
It forms and the preparation method is the same as that of Example 1.
Formula 3：The composition of all components with the preparation method is the same as that of Example 1.
Volunteer：Randomly select health 30 people of men and women volunteer, the age between 18~65 years old, no serious systemic disease
Disease, disimmune defect or autoimmune disease person, without anaphylactia, various cosmetics etc. are not used in tested period, and
It can empirically require to complete defined sample use.Experimental method：Volunteer is divided into 3 groups by above-mentioned formula, every group of 10 people will
The volunteer that this 3 group of formula carries out 28 days tries out test, and each using once in the morning, afternoon and evening daily, position on probation is face.Tester
Device：The skin elasticity CotometerMPA580 hosts of German CK companies manufacture；The dermal melanin of German CK companies manufacture
MexameterMX18 test probes.Facial test condition：Face test carries out indoors, no sunburst or light direct projection.It surveys
White-skinned face function product cannot be used within 2~3 days before examination (including other cosmetics, topical drug or health products for oral administration).Test before by
Examination person needs unified cleaning skin of face, with dry face tissue wiped clean.
Principle based on spectral absorption is determined by the volume reflection after measuring the illumination of specific wavelength on human skin
The content of melanin in skin.The test probe of detector for pigment is made of light source emitter and receiver, separately has spring to protect
It holds constant to the pressure of skin during detection.It is respectively tri- kinds of wavelength of 568nm, 660nm, 880nm that the transmitter of probe, which sends out wavelength,
Light be radiated at skin surface, receiver measures the light of skin reflex.Since the amount of transmitting light is certain, can survey
Go out the amount for the light being absorbed by the skin, measure the content of dermal melanin.Data in table 2 are the dermal melanin content measured.
2 each volunteer's dermal melanin comparision contents (%) of table
Obtained data are formulated to above-mentioned 3 with SPASS17.0 and carry out paired-samples T-test, obtain following result：
Formula 1：
Paired samples statistic
Paired samples related coefficient
| N | Related coefficient | Sig. | ||
| Pair 1 | 1st day ＆ the 28th day | 10 | .920 | .000 |
Paired samples are examined
From data above, it can be seen that, after it have passed through the test period of 28 days, the dermal melanin of volunteer contains formula 1
It measures mean value and declines 13.4, skin brightening trend is apparent (P ＜ 0.05).
Formula 2：
Paired samples statistic
Paired samples related coefficient
| N | Related coefficient | Sig. | ||
| Pair 1 | 1st day ＆ the 28th day | 10 | .787 | .007 |
Paired samples are examined
From data above, it can be seen that, after it have passed through the test period of 28 days, the dermal melanin of volunteer contains formula 2
It measures mean value and declines 11.4, skin brightening trend is apparent (P ＜ 0.05).
Formula 3：
Paired samples statistic
Paired samples related coefficient
| N | Related coefficient | Sig. | ||
| Pair 1 | 1st day ＆ the 28th day | 10 | .795 | .006 |
Paired samples are examined
From data above, it can be seen that, after it have passed through the test period of 28 days, the dermal melanin of volunteer contains formula 3
It measures mean value and declines 22, skin brightening trend is apparent (P ＜ 0.05).
The experimental results showed that, 3 kinds of test formulations are after it have passed through the test period of 28 days, the skin black of volunteer above
Cellulose content decreases, and skin brightening trend is apparent, wherein 3 are formulated after it have passed through the test period of 28 days, volunteer's
The reduction of dermal melanin content is the most apparent, with obvious effects to be better than preceding two group of formula.It is shown by consumer tests, it is of the invention
5 kinds of main component neohesperidin dihydrochalcones, scutelloside, flavones in mulberry leaves, phloretin, polysaccharides connection in whitening and skin-protecting lotion
Compounding is closed, has positive effect to skin whitening, and whitening effect is better than exclusive use neohesperidin dihydrochalcone and scutelloside
The formula that flavones in mulberry leaves, phloretin, polysaccharides compound is used alone in compounding.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, that is made any repaiies
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of whitening and skin-protecting lotion, which is characterized in that including following components by weight percentage：
Neohesperidin dihydrochalcone 0.1%~10%, scutelloside 0.1%~10%, turtle turtle pectin 0.1%~5%, turtle turtle essence
Oil 0.1%~2%, organic solvent 10%~20%, carbomer 0.01%~0.1%, surplus is water.
2. whitening and skin-protecting lotion according to claim 1, which is characterized in that including by weight percentage with the following group
Point：
Neohesperidin dihydrochalcone 0.6%~8%, scutelloside 0.1%~5%, turtle turtle pectin 0.5%~5%, turtle turtle essential oil
0.1%~2%, organic solvent 10%~20%, carbomer 0.01%~0.1%, surplus is water.
3. whitening and skin-protecting lotion according to claim 1 or 2, which is characterized in that
Flavones in mulberry leaves is further included in the whitening and skin-protecting lotion, weight percent is 0.1%~5%.
4. whitening and skin-protecting lotion according to claim 3, which is characterized in that
Flavones in mulberry leaves is further included in the whitening and skin-protecting lotion, weight percent is 0.1%~3%.
5. whitening and skin-protecting lotion according to claim 1 or 2, which is characterized in that
Following components by weight percentage is further included in the whitening and skin-protecting lotion：Phloretin 0.1%~5%, matrimony vine is more
Sugar 0.1%~5%.
6. whitening and skin-protecting lotion according to claim 5, which is characterized in that
Following components by weight percentage is further included in the whitening and skin-protecting lotion：Phloretin 0.5%~5%, matrimony vine is more
Sugar 0.1%~3%.
7. whitening and skin-protecting lotion according to claim 1 or 2, which is characterized in that
The organic solvent is one or more of butanediol, propylene glycol, glycerine, diethylene glycol (DEG).
8. the preparation method of the whitening and skin-protecting lotion described in any one of claim 1 to 7, which is characterized in that including following step
Suddenly：
Organic solvent and carbomer are placed in cutter, turtle turtle pectin and water are added in shear history, then adds in new orange peel
Glycosides dihydrochalcone, scutelloside finally add turtle turtle essential oil to get to the whitening and skin-protecting lotion.
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Address after: 417100 Loudi hi tech Industrial Development Zone, Loudi City, Hunan Province Patentee after: LIANYUAN KANGBIOTECH CO.,LTD. Patentee after: Lianyuan Kangcheng Agriculture and Forestry Technology Development Co.,Ltd. Address before: 417100 Loudi hi tech Industrial Development Zone, Loudi City, Hunan Province Patentee before: LIANYUAN KANGBIOTECH CO.,LTD. Patentee before: Lianyuan Kangcheng Agricultural Technology Development Co.,Ltd. |