CN108175844A - Tongjing granule and preparation method thereof - Google Patents

Tongjing granule and preparation method thereof Download PDF

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Publication number
CN108175844A
CN108175844A CN201711442942.5A CN201711442942A CN108175844A CN 108175844 A CN108175844 A CN 108175844A CN 201711442942 A CN201711442942 A CN 201711442942A CN 108175844 A CN108175844 A CN 108175844A
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weight
parts
tongjing
granule
preparation
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CN201711442942.5A
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司会贞
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Henan Ming Zhen Fang Pharmaceutical Technology Co Ltd
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Henan Ming Zhen Fang Pharmaceutical Technology Co Ltd
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Priority to CN201711442942.5A priority Critical patent/CN108175844A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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Abstract

The present invention relates to Tongjing granule and preparation method thereof, the activated feedstock for preparing the Tongjing granule includes Radix Angelicae Sinensis, cassia twig, Chinese herbaceous peony, asarum, Radix Glycyrrhizae, the stem pith of the rice-paper plant, jujube, ginger and Radix Codonopsis.The Tongjing granule that the present invention prepares can improve cold body state, can effectively alleviate cold dysmenorrhoea, and preparation method is simple, and active material extraction avoids the occurrence of bonding phenomenon, and technical process is succinct, avoids wasting.

Description

Tongjing granule and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, and in particular to Tongjing granule and preparation method thereof.
Background technology
Dysmenorrhoea belongs to cold dysmenorrhoea more, has different syndromes according to the difference at cold solidifying position, clinical common menstrual period abdomen Pain can mostly be alleviated using hot-water bag hot compress, and the phenomenon that trick is ice-cold, forehead is ice-cold is being susceptible to around menstrual period.Radix Angelicae Sinensis four Inverse soup is usually used in treating chill diseases caused by external factors, mainly has effects that coke in help, Radix Codonopsis is added in the party, can enhance spleen soil Transportation capabilities promote generation qi and blood to solve the problems, such as the deficiency of blood.Inventor is developed a kind of convenient for taking based on this side Granule, long-term use can effectively alleviate cold dysmenorrhoea symptom, thereby completing the present invention.
Invention content
The object of the present invention is to provide a kind of granules for improving, treating cold dysmenorrhoea symptom and preparation method thereof.
Above-mentioned purpose that the invention is realized by the following technical scheme：
Tongjing granule, the activated feedstock for preparing the Tongjing granule include Radix Angelicae Sinensis, cassia twig, Chinese herbaceous peony, asarum, Radix Glycyrrhizae, the stem pith of the rice-paper plant, big Jujube, ginger and Radix Codonopsis.
Preferably, the activated feedstock for preparing the Tongjing granule includes Radix Angelicae Sinensis 4-6 parts by weight, cassia twig 3-5 parts by weight, Chinese herbaceous peony 3-5 parts by weight, asarum 1-2 parts by weight, Radix Glycyrrhizae 2-3 parts by weight, stem pith of the rice-paper plant 2-3 parts by weight, jujube 6-8 parts by weight, ginger 6-10 weights Measure part and Radix Codonopsis 6-10 parts by weight.
It is highly preferred that the activated feedstock for preparing the Tongjing granule includes 5 parts by weight of Radix Angelicae Sinensis, 4 parts by weight of cassia twig, Chinese herbaceous peony 4 Parts by weight, 1 parts by weight of asarum, 2 parts by weight of Radix Glycyrrhizae, 3 parts by weight of the stem pith of the rice-paper plant, 10 weight of 8 parts by weight of jujube, 8 parts by weight of ginger and Radix Codonopsis Measure part.
The raw material for preparing the Tongjing granule further includes starch, lactose, microcrystalline cellulose and citric acid.
The preparation method of the Tongjing granule, the described method comprises the following steps：
（1）Ginger, Radix Codonopsis, cassia twig are cut into fritter, the frying 20min in frying pan, grind into powder crosses 80 mesh sieve；
（2）It after Removing Kernel for Date, is mixed with Radix Angelicae Sinensis, Chinese herbaceous peony, asarum, Radix Glycyrrhizae, the stem pith of the rice-paper plant, adds in isopropanol water solution and be warming up to 70 DEG C, infusion 2h is filtered while hot, and filtrate is concentrated into no alcohol taste, obtains paste A；
（3）By step（1）Powder mixed with the paste A, add in water thereto, be to slowly warm up to boil, boil 2h, take advantage of Heat filtering, filtrate concentration, obtains active material B；
（4）Starch, lactose, microcrystalline cellulose and citric acid are added in into active material B, softwood processed after mixing, dry, whole grain, Packing, obtains Tongjing granule.
Preferably, step（2）Middle isopropanol water solution is the isopropanol water solution of volume fraction 75-95%.
Step（3）In, since active material ingredients are complex, resistance is gradually increased in filtrate concentration process, it is difficult to complete Full water removal drying, and need to add in water softwood during subsequent wet plasmid, therefore, concentrate the filtrate to volume and reduce three points 3/2nds to four, auxiliary material softwood can be directly added into.
Step（4）In, relative to every parts by weight Radix Codonopsis, the addition of auxiliary material is 10-15 weight starch, 5-8 parts by weight Lactose, 5-8 parts by weight microcrystalline cellulose and 2-3 parts by weight citric acids.
Step（4）In, the drying is heated-air drying at 100-105 DEG C.
The specification of gained Tongjing granule be 10g, 15g, 20g, warm boiled water, once a day, be respectively adapted to menstrual period drink, It drank before menstrual period and usually drinks.
The Tongjing granule that the present invention prepares can improve cold body state, can effectively alleviate cold dysmenorrhoea, preparation method Simply, active material extraction avoids the occurrence of bonding phenomenon, and technical process is succinct, avoids wasting.
Specific embodiment
The present invention is further described with reference to specific embodiment.
Embodiment 1
Tongjing granule is prepared using following methods：
（1）80g gingers, 100g Radix Codonopsis, 40g cassia twig are cut into fritter, the frying 20min in frying pan, grind into powder crosses 80 mesh Sieve；
（2）It after 80g Removing Kernel for Date, is mixed with 50g Radix Angelicae Sinensis, 40g Chinese herbaceous peonies, 10g asarums, 20g Radix Glycyrrhizaes, the 30g stem piths of the rice-paper plant, adds in volume The isopropanol water solution of score 75% is warming up to 70 DEG C, and infusion 2h is filtered while hot, and filtrate is concentrated into no alcohol taste, obtains paste A；
（3）By step（1）Powder mixed with the paste A, thereto add in 1L water, be to slowly warm up to boil, boil 2h, It filters while hot, filtrate is concentrated into volume about 300mL, obtains active material B；
（4）1kg starch, 500g lactose, 500g microcrystalline celluloses and 200g citric acids are added in into active material B, is made after mixing Softwood, dry, whole grain, packing obtain Tongjing granule.
Embodiment 2
Tongjing granule is prepared using following methods：
（1）60g gingers, 80g Radix Codonopsis, 50g cassia twig are cut into fritter, the frying 20min in frying pan, grind into powder crosses 80 mesh Sieve；
（2）It after 60g Removing Kernel for Date, is mixed with 40g Radix Angelicae Sinensis, 50g Chinese herbaceous peonies, 20g asarums, 30g Radix Glycyrrhizaes, the 30g stem piths of the rice-paper plant, adds in volume The isopropanol water solution of score 95% is warming up to 70 DEG C, and infusion 2h is filtered while hot, and filtrate is concentrated into no alcohol taste, obtains paste A；
（3）By step（1）Powder mixed with the paste A, thereto add in 1L water, be to slowly warm up to boil, boil 2h, It filters while hot, filtrate is concentrated into volume about 300mL, obtains active material B；
（4）1kg starch, 500g lactose, 500g microcrystalline celluloses and 200g citric acids are added in into active material B, is made after mixing Softwood, dry, whole grain, packing obtain Tongjing granule.
Embodiment 3
Tongjing granule is prepared using following methods：
（1）100g gingers, 60g Radix Codonopsis, 60g cassia twig are cut into fritter, the frying 20min in frying pan, grind into powder crosses 80 mesh Sieve；
（2）It after 70g Removing Kernel for Date, is mixed with 60g Radix Angelicae Sinensis, 50g Chinese herbaceous peonies, 20g asarums, 20g Radix Glycyrrhizaes, the 20g stem piths of the rice-paper plant, adds in volume The isopropanol water solution of score 85% is warming up to 70 DEG C, and infusion 2h is filtered while hot, and filtrate is concentrated into no alcohol taste, obtains paste A；
（3）By step（1）Powder mixed with the paste A, thereto add in 1L water, be to slowly warm up to boil, boil 2h, It filters while hot, filtrate is concentrated into volume about 300mL, obtains active material B；
（4）1kg starch, 500g lactose, 500g microcrystalline celluloses and 200g citric acids are added in into active material B, is made after mixing Softwood, dry, whole grain, packing obtain Tongjing granule.
Above only describes the better embodiment of the present invention, but the present invention is not limited to above-described embodiments.This field skill Art personnel should all fall into the present invention it is understood that any same or similar means of the technology of the present invention effect can be realized Protection domain in.

Claims (9)

1. Tongjing granule, the activated feedstock for preparing the Tongjing granule includes Radix Angelicae Sinensis, cassia twig, Chinese herbaceous peony, asarum, Radix Glycyrrhizae, the stem pith of the rice-paper plant, big Jujube, ginger and Radix Codonopsis.
2. Tongjing granule according to claim 1, which is characterized in that the activated feedstock for preparing the Tongjing granule includes working as Return 4-6 parts by weight, cassia twig 3-5 parts by weight, Chinese herbaceous peony 3-5 parts by weight, asarum 1-2 parts by weight, Radix Glycyrrhizae 2-3 parts by weight, stem pith of the rice-paper plant 2-3 weights Measure part, jujube 6-8 parts by weight, ginger 6-10 parts by weight and Radix Codonopsis 6-10 parts by weight.
3. Tongjing granule according to claim 1, which is characterized in that the activated feedstock for preparing the Tongjing granule includes working as Return 5 parts by weight, 4 parts by weight of cassia twig, 4 parts by weight of Chinese herbaceous peony, 1 parts by weight of asarum, 2 parts by weight of Radix Glycyrrhizae, 3 parts by weight of the stem pith of the rice-paper plant, 8 weight of jujube Measure 10 parts by weight of part, 8 parts by weight of ginger and Radix Codonopsis.
4. Tongjing granule according to claim 1, which is characterized in that the raw material for preparing the Tongjing granule further includes shallow lake Powder, lactose, microcrystalline cellulose and citric acid.
5. the preparation method of the Tongjing granule described in any one of claim 1-4, the described method comprises the following steps：
（1）Ginger, Radix Codonopsis, cassia twig are cut into fritter, the frying 20min in frying pan, grind into powder crosses 80 mesh sieve；
（2）It after Removing Kernel for Date, is mixed with Radix Angelicae Sinensis, Chinese herbaceous peony, asarum, Radix Glycyrrhizae, the stem pith of the rice-paper plant, adds in isopropanol water solution and be warming up to 70 DEG C, infusion 2h is filtered while hot, and filtrate is concentrated into no alcohol taste, obtains paste A；
（3）By step（1）Powder mixed with the paste A, add in water thereto, be to slowly warm up to boil, boil 2h, take advantage of Heat filtering, filtrate concentration, obtains active material B；
（4）Starch, lactose, microcrystalline cellulose and citric acid are added in into active material B, softwood processed after mixing, dry, whole grain, Packing, obtains Tongjing granule.
6. preparation method according to claim 5, which is characterized in that step（2）Middle isopropanol water solution is volume fraction The isopropanol water solution of 75-95%.
7. preparation method according to claim 5, which is characterized in that step（3）In, it concentrates the filtrate to volume and reduces three 3/1 bis- to four.
8. preparation method according to claim 5, which is characterized in that step（4）In, it is auxiliary relative to every parts by weight Radix Codonopsis The addition of material is 10-15 weight starch, 5-8 parts by weight of lactose, 5-8 parts by weight microcrystalline cellulose and 2-3 parts by weight citrons Acid.
9. preparation method according to claim 5, which is characterized in that step（4）In, the drying is at 100-105 DEG C Heated-air drying.
CN201711442942.5A 2017-12-27 2017-12-27 Tongjing granule and preparation method thereof Withdrawn CN108175844A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711442942.5A CN108175844A (en) 2017-12-27 2017-12-27 Tongjing granule and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711442942.5A CN108175844A (en) 2017-12-27 2017-12-27 Tongjing granule and preparation method thereof

Publications (1)

Publication Number Publication Date
CN108175844A true CN108175844A (en) 2018-06-19

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Country Status (1)

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