CN108175807A - A kind of tablet for treating chemical damage - Google Patents
A kind of tablet for treating chemical damage Download PDFInfo
- Publication number
- CN108175807A CN108175807A CN201810153969.0A CN201810153969A CN108175807A CN 108175807 A CN108175807 A CN 108175807A CN 201810153969 A CN201810153969 A CN 201810153969A CN 108175807 A CN108175807 A CN 108175807A
- Authority
- CN
- China
- Prior art keywords
- tablet
- drying
- chemical damage
- fruit
- chinese wolfberry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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Abstract
The invention discloses a kind of tablets for treating chemical damage; the content of each substance includes 1100 1200g of ginkgo leaf, 700 800g of the fruit of Chinese wolfberry, 5 7g of vitamin E, 3 4g of tea polyphenols, 20 25g of taurine, 240 260g of dextrin, 4 6g of magnesium stearate in tablet, and the present invention relates to tablet technology fields.The tablet of the treatment chemical damage is made of ginkgo leaf, the fruit of Chinese wolfberry, vitamin E, tea polyphenols, taurine raw material, from fong theory and clinical practice verification, all has the function of there is assistant protection function to chemical damage;The raw material used in formula can be taken for a long time, be safely and effectively health food without toxic side effect.
Description
Technical field
The present invention relates to tablet technology field, specially a kind of tablet for treating chemical damage.
Background technology
Liver is the parenchymatous organ of intraperitoneal maximum, undertakes the important physiological function of human body.Liver cell is to the resistance to of anoxic
Stress is poor, therefore has arteria hepatica and portal vein to provide abundant blood supply, and has size bile duct with blood vessel with row conveying bile.
It is located at the deep of upper right abdomen, there is the protection of the lower wall of the chest and diaphram.But since liver volume is big, quality is crisp, once by violence
Easily damage, occurs intraperitoneal hemorrhage or bile leakage, and causing bleeding property shock or biliary peritonitis, consequence are serious, it is necessary to
Diagnosis in time and correct processing.
Existing treatment hepatic injury is generally treated using western medicine tablet, takes such tablet for a long time to body with larger
Negative interaction, when serious it is possible that endanger patient body health, using with limitation.
Invention content
In view of the deficiencies of the prior art, the present invention provides a kind of tablet for treating chemical damage, by ginkgo leaf, Chinese holly
Matrimony vine, vitamin E, tea polyphenols, taurine raw material composition from fong theory and clinical practice verification, all have to chemically liver
Damage plays the role of assistant protection function;The raw material used in formula can be taken for a long time, be safe and effective without toxic side effect
Health food.
In order to achieve the above object, the present invention is achieved by the following technical programs:A kind of chemical damage for the treatment of
Tablet, the content of each substance includes ginkgo leaf 1100-1200g, fruit of Chinese wolfberry 700-800g, vitamin E 5-7g, tea polyphenols in tablet
3-4g, taurine 20-25g, dextrin 240-260g, magnesium stearate 4-6g.
A kind of tablet for treating chemical damage, production technology specifically comprise the following steps:
The arrangement of step 1, the fruit of Chinese wolfberry and ginkgo leaf processes:Staff puts the fruit of Chinese wolfberry on sorting table, removes by hand
The impurity such as contained sawdust, sandstone and mould product etc. are lost in medicinal material;The fruit of Chinese wolfberry after selection is put on medicine-washing machine, WATER-WASHING METHOD is medicinal material
Wash clean;Ginkgo leaf, which is put in rinse bath, to be rinsed, dries;Medicinal material after cleaning is put heated-air circulation oven to dry in time, drying temperature
Degree control is at 70~80 DEG C;The fruit of Chinese wolfberry after drying is carried out coarse crushing in Roughpulverizer;The independent coarse crushing of ginkgo leaf;It will be silver-colored
It is spare after the drying of apricot leaf coarse powder;Calculated yield, yield spectra 90~98%;
Step 2, raw material extraction:Choosing ginkgo leaf coarse powder 450kg adds 10 times of 80% ethyl alcohol to impregnate 1 hour, refluxing extraction 2
Hour, it puts to room temperature, filtering, the dregs of a decoction add 8 times of 80% alcohol reflux to extract 2 hours again, put to room temperature, the dregs of a decoction are through two-stage centrifugal
Machine separation discards, and filtrate heating is boiled, distillation to no alcohol taste;Distill liquid condensing, recycling ethyl alcohol;Choose fruit of Chinese wolfberry coarse powder 300kg
10 times of water is added to impregnate 30 minutes, refluxing extraction 2 hours is put to room temperature, filtering, and the dregs of a decoction add 8 times of water refluxing extractions 2 hours again, put
To room temperature, the dregs of a decoction are discarded through the separation of two-stage centrifugal machine, merging more than extracting solution, with hypervelocity disc centrifuge decontamination;Filtrate
Put fluid reservoir;
Step 3, filtrate concentration:The filtrate extracted in step 2 is pumped into Three-effect concentration device, pays attention to controlling technological parameter;
One effect:0.08~0.09Mpa of vapour pressure, 0.03~0.04Mpa of vacuum degree, 65~70 DEG C of temperature;Two effects:Vapour pressure 0.08~
0.09Mpa, 0.05~0.06Mpa of vacuum degree, 60~65 DEG C of temperature;Triple effect:0.08~0.09Mpa of vapour pressure, vacuum degree 0.07
50~55 DEG C of~0.08Mpa, temperature;When concentration cannot recycle, the liquid in two effects, triple effect is all focused in an effect
It is concentrated, concentrate proportion is measured in 65~70 DEG C of temperature, when proportion reaches 1.10~1.15, will be concentrated with gear pump
Liquid pump enters spherical concentrator and is concentrated, and concentrate proportion is measured in 55~60 DEG C of temperature, when proportion reaches 1.35~1.40
When, dispensing valve is opened, is put into the cleaning container that clean area is made ready beforehand for, weighs the weight of thick paste, the volume range of thick paste
24~28% for crude drug amount;
Step 4, thick paste vacuum drying:The thick paste prepared in step 3 is tiled in stainless steel disc, thickness in 3~5cm,
The stainless steel disc for filling thick paste is put in vacuum drying chamber, is dried to moisture 3~5%, dry cream is fitted into bag, is tightened pocket and is claimed
Weight;Yield spectra 44~48%;
Step 5, dry cream crush:The dry cream prepared in step 4 is poured into pulverizer, starts pulverizer and dry cream is ground into
80~100 targeted fine powders are crossed, after crushing, dried cream powder is packed into clean polybag, tightens mouth, the clean braiding of housing
Bag, tightens mouth, simultaneously calculated yield of weighing;Yield spectra 95~98%;It fills in and asks verification certificate, detection character, discriminating and hygiene;
Step 6, raw material mixing:Vitamin E, tea polyphenols, taurine are mixed by formula rate, it is omnipotent with WF-180B types
Pulverizer crushes, revolution 4000rpm;Pay attention to answering first starting device, then above-mentioned slightly mixed raw material is uniformly added into hopper;Sieving and powder
It is broken to synchronously complete;Cyclic annular sieve plate eyelet control mesh number is 150 mesh;Above-mentioned mixed powder 14kg, dried cream powder 84kg, dextrin 100kg are put
In in V-Mixer, inventory is about the 30% of mixing machine capacity, and adjusting device rotating speed reaches the 30~40% of critical speed
When, about 15min is continuously run, is stopped to get uniformly mixed raw material;
Step 7, granulation:Raw material mixed in step 6 is added in into ethyl alcohol softwood;The dosage of ethyl alcohol is generally in dry material
8~12%, specific dosage should control is adding the mixed material of ethyl alcohol convenient for be granulated subject to;Softwood puts wet-mixing granulation
In machine, start the main stirring button of wet mixing pelletizer, motor is closed in operation after five minutes, starts cutter motor, selection stirring
Fast shelves and the slow shelves of cutting are pelletized 3 minutes;80~100 μm of cumulative distribution >=90% of granularity, about 400 μm of average particle size (grain size);
Step 8, particle drying:Wet granular in step 7 is equably split in stainless steel baking pan, drying vehicle is pushed into
Drying chamber when particle is dried to water content 3~5%, takes out dried particle;
Step 9, whole grain:14 mesh sieve is installed, starts pelletizing machine, dry particl dried in step 8 is sequentially added, whole grain
After weigh, calculated yield carries out material balance;
Step 10 is always mixed:Conforming particle is put Mixers with Multi-direction Movement, adds in magnesium stearate 2kg, starts mixing machine mixing
15 minutes, discharging is shut down, fills in and asks verification certificate;
Step 11, tabletting:For particle after the assay was approved using GZPKI32 type stamping machine tablettings, 32 punchings adjust punching press pressure
Power about 30KN makes every piece weight for 0.5g, checks that average piece weight is primary, and makes a record every 20 minutes;
Step 12 takes up:Piece is fitted into together with cloth bag in clean stainless steel barrel, intermediate station is sent into sealing;Bucket wall sticks mark
Label indicate the name of an article, specification, lot number and total quantity, date of manufacture, operator;
Step 13, inner packing:It is dispensed by 60 every bottle, theoretical yield 400,000, continuous production yield answers >=95%;
Step 14, outer packing:Specification:0.5g/ piece × 60 piece/bottle × 12 bottles/middle box × 20 in box/part;Packing instructions:Mark
Label are rectified, and lot number is clear;Packaging material print content meets national relevant regulations, and clear writing is errorless;Vanning is tight, jail
Gu lot number is clear, there is work certificate;
Step 15 is examined and is put in storage:It is examined according to company standard, qualification can be sold into library.
As present invention further optimization scheme, the rotating speed of two-stage centrifugal machine is 800~1000 turns/min in step 2,
The rotating speed of hypervelocity disc centrifuge is 5000 turns/min.
As present invention further optimization scheme, 65~70 DEG C of the drying temperature of drying box in step 4;Vacuum degree 0.07
~0.08Mpa.
As present invention further optimization scheme, the tea polyphenols be TP-I types, purity >=90%.
As present invention further optimization scheme, a concentration of the 60~80% of ethyl alcohol in step 7.
As present invention further optimization scheme, 65~70 DEG C of the drying temperature of drying chamber in step 8.
Advantageous effect
The present invention provides a kind of tablets for treating chemical damage.Has following advantageous effect:
The tablet of the treatment chemical damage, by ginkgo leaf, the fruit of Chinese wolfberry, vitamin E, tea polyphenols, taurine raw material group
Into, from fong theory and clinical practice verification, all have the function of there is assistant protection function to chemical damage;It is adopted in formula
Raw material can be taken for a long time, be safely and effectively health food without toxic side effect.
Specific embodiment
The present invention provides a kind of embodiments:A kind of tablet for treating chemical damage, the content of each substance in tablet
Including ginkgo leaf 1100-1200g, fruit of Chinese wolfberry 700-800g, vitamin E 5-7g, tea polyphenols 3-4g, taurine 20-25g, dextrin
240-260g, magnesium stearate 4-6g.
A kind of tablet for treating chemical damage, production technology specifically comprise the following steps:
The arrangement of step 1, the fruit of Chinese wolfberry and ginkgo leaf processes:Staff puts the fruit of Chinese wolfberry on sorting table, removes by hand
The impurity such as contained sawdust, sandstone and mould product etc. are lost in medicinal material;The fruit of Chinese wolfberry after selection is put on medicine-washing machine, WATER-WASHING METHOD is medicinal material
Wash clean;Ginkgo leaf, which is put in rinse bath, to be rinsed, dries;Medicinal material after cleaning is put heated-air circulation oven to dry in time, drying temperature
Degree control is at 70~80 DEG C;The fruit of Chinese wolfberry after drying is carried out coarse crushing in Roughpulverizer;The independent coarse crushing of ginkgo leaf;It will be silver-colored
It is spare after the drying of apricot leaf coarse powder;Calculated yield, yield spectra 90~98%;
Step 2, raw material extraction:Choosing ginkgo leaf coarse powder 450kg adds 10 times of 80% ethyl alcohol to impregnate 1 hour, refluxing extraction 2
Hour, it puts to room temperature, filtering, the dregs of a decoction add 8 times of 80% alcohol reflux to extract 2 hours again, put to room temperature, the dregs of a decoction are through two-stage centrifugal
Machine separation discards, and filtrate heating is boiled, distillation to no alcohol taste;Distill liquid condensing, recycling ethyl alcohol;Choose fruit of Chinese wolfberry coarse powder 300kg
10 times of water is added to impregnate 30 minutes, refluxing extraction 2 hours is put to room temperature, filtering, and the dregs of a decoction add 8 times of water refluxing extractions 2 hours again, put
To room temperature, the dregs of a decoction are discarded through the separation of two-stage centrifugal machine, merging more than extracting solution, with hypervelocity disc centrifuge decontamination;Filtrate
Put fluid reservoir;The rotating speed of two-stage centrifugal machine is 800~1000 turns/min, the rotating speed of the disc centrifuge that exceeds the speed limit for 5000 turns/
min;
Step 3, filtrate concentration:The filtrate extracted in step 2 is pumped into Three-effect concentration device, pays attention to controlling technological parameter;
One effect:0.08~0.09Mpa of vapour pressure, 0.03~0.04Mpa of vacuum degree, 65~70 DEG C of temperature;Two effects:Vapour pressure 0.08~
0.09Mpa, 0.05~0.06Mpa of vacuum degree, 60~65 DEG C of temperature;Triple effect:0.08~0.09Mpa of vapour pressure, vacuum degree 0.07
50~55 DEG C of~0.08Mpa, temperature;When concentration cannot recycle, the liquid in two effects, triple effect is all focused in an effect
It is concentrated, concentrate proportion is measured in 65~70 DEG C of temperature, when proportion reaches 1.10~1.15, will be concentrated with gear pump
Liquid pump enters spherical concentrator and is concentrated, and concentrate proportion is measured in 55~60 DEG C of temperature, when proportion reaches 1.35~1.40
When, dispensing valve is opened, is put into the cleaning container that clean area is made ready beforehand for, weighs the weight of thick paste, the volume range of thick paste
24~28% for crude drug amount;
Step 4, thick paste vacuum drying:The thick paste prepared in step 3 is tiled in stainless steel disc, thickness in 3~5cm,
The stainless steel disc for filling thick paste is put in vacuum drying chamber, is dried to moisture 3~5%, dry cream is fitted into bag, is tightened pocket and is claimed
Weight;Yield spectra 44~48%;65~70 DEG C of the drying temperature of drying box;0.07~0.08Mpa of vacuum degree;
Step 5, dry cream crush:The dry cream prepared in step 4 is poured into pulverizer, starts pulverizer and dry cream is ground into
80~100 targeted fine powders are crossed, after crushing, dried cream powder is packed into clean polybag, tightens mouth, the clean braiding of housing
Bag, tightens mouth, simultaneously calculated yield of weighing;Yield spectra 95~98%;It fills in and asks verification certificate, detection character, discriminating and hygiene;
Step 6, raw material mixing:Vitamin E, tea polyphenols, taurine are mixed by formula rate, it is omnipotent with WF-180B types
Pulverizer crushes, revolution 4000rpm;Pay attention to answering first starting device, then above-mentioned slightly mixed raw material is uniformly added into hopper;Sieving and powder
It is broken to synchronously complete;Cyclic annular sieve plate eyelet control mesh number is 150 mesh;Above-mentioned mixed powder 14kg, dried cream powder 84kg, dextrin 100kg are put
In in V-Mixer, inventory is about the 30% of mixing machine capacity, and adjusting device rotating speed reaches the 30~40% of critical speed
When, about 15min is continuously run, is stopped to get uniformly mixed raw material;
Step 7, granulation:Mixed raw material in step 6 is added in into ethyl alcohol softwood, a concentration of the 60~80% of ethyl alcohol;
Generally the 8~12% of dry material, specific dosage should be controlled adding the mixed material of ethyl alcohol convenient for being granulated the dosage of ethyl alcohol
Subject to;Softwood is put in wet mixing pelletizer, starts the main stirring button of wet mixing pelletizer, and motor is closed in operation after five minutes,
Start cutter motor, selection stirs fast shelves and cuts slow shelves and pelletizes 3 minutes;80~100 μm of cumulative distribution >=90% of granularity are put down
Equal about 400 μm of granularity (grain size);
Step 8, particle drying:Wet granular in step 7 is equably split in stainless steel baking pan, drying vehicle is pushed into
Drying chamber, the drying temperature of drying chamber are set as 65~70 DEG C, when particle is dried to water content 3~5%, take out dried particle;
Step 9, whole grain:14 mesh sieve is installed, starts pelletizing machine, dry particl dried in step 8 is sequentially added, whole grain
After weigh, calculated yield carries out material balance;
Step 10 is always mixed:Conforming particle is put Mixers with Multi-direction Movement, adds in magnesium stearate 2kg, starts mixing machine mixing
15 minutes, discharging is shut down, fills in and asks verification certificate;
Step 11, tabletting:For particle after the assay was approved using GZPKI32 type stamping machine tablettings, 32 punchings adjust punching press pressure
Power about 30KN makes every piece weight for 0.5g, checks that average piece weight is primary, and makes a record every 20 minutes;
Step 12 takes up:Piece is fitted into together with cloth bag in clean stainless steel barrel, intermediate station is sent into sealing;Bucket wall sticks mark
Label indicate the name of an article, specification, lot number and total quantity, date of manufacture, operator;
Step 13, inner packing:It is dispensed by 60 every bottle, theoretical yield 400,000, continuous production yield answers >=95%;
Step 14, outer packing:Specification:0.5g/ piece × 60 piece/bottle × 12 bottles/middle box × 20 in box/part;Packing instructions:Mark
Label are rectified, and lot number is clear;Packaging material print content meets national relevant regulations, and clear writing is errorless;Vanning is tight, jail
Gu lot number is clear, there is work certificate;
Step 15 is examined and is put in storage:It is examined according to company standard, qualification can be sold into library.
The tea polyphenols be TP-I types, purity >=90%.
Ginkgo leaf is the dried leaf of Ginkgoaceae Ginkgo plant Ginkgo biloba Ginkgo biloba L..Nature and flavor are sweet, bitter, puckery, flat,
Thoughts of returning home lung channel, have the function of invigorating heart astringe the lung, dampness elimination antidiarrheal, promoting blood circulation and removing blood stasis, promoting blood circulation, activating collaterals.Main component is GINKGO BILOBA EXTRACT (rue
Fragrant glycosides, kaempferol -3- rhamnoses glucoside, kaempferol, Quercetin, Isorhamnetin, ginkegetin, Isoginkgetin
Deng) and the chemical substances such as lactone (the new lactone of ginkalide A/B/C/, ginkgo).Study of pharmacy shows ginkgo leaf total flavonoid pair
Hepatic injury caused by carbon tetrachloride and ethyl alcohol has protective effect;Ginkgolides causes carbon tetrachloride rats'liver reperfusion injury model to fill
The raising of alanine aminotransferase, lactic dehydrogenase has obvious inhibiting effect in flow liquid;Ginkgo biloba p.e is to tetrachloro-methane induction
Rat liver fibrosis have apparent inhibiting effect, while the hepatotoxicity wind agitation of Antituberculous Drugs has certain protective effect.Ginkgo
It is related that the above-mentioned effect of leaf extract is considered anti-oxidant to its, anti-liver lipid peroxidation.
The fruit of Chinese wolfberry:It is sweet in flavor, it is mild-natured, return liver and kidney channel, can be nourishing liver and kidney, benefiting shrewd head, be the common help of Traditional Chinese Medicine
Medicine.Modern pharmacology pharmacodynamics test confirm, water-soluble polysaccharide-polysaccharides contained by the fruit of Chinese wolfberry by preventing lipid peroxidation,
It is not damaged with the meinbranous structure for protecting liver cell, prevents the damage of endoplasmic reticulum, promote protein synthesis and detoxication, after
And injury of mitochondria and protein denaturation accordingly mitigate, and reduce cellular damage, and have stimulated hepatic cell regeneration, restore liver function
Effect.The experimental results showed that there is protective effect to liver tissue injury caused by carbon tetrachloride.
Vitamin E is natural powerful antioxidant, is widely used in food industry as food additives.Research is recognized
For vitamin E can remove interior free yl, be a kind of strength lipid peroxidation antagonist.It is demonstrated experimentally that vitamin E have pair
The protective effect of animal acute alcoholism;To the antagonism of yellow phosphorus acute poisoning liver damage.Vitamin E is to chemically liver
Damage truly has protective effect.
Tea polyphenols are one of tealeaves major physiological active constituents, are good free radical scavengers based on catechin.
Tea polyphenols are widely used in as food additives in food industry.Research has shown that tea polyphenols are to carbon tetrachloride induced mice
Hepatic injury has protective effect, can effectively inhibit alcoholic liver injury, there is Anti Fibrosis of Liver and Cadmium resistance acute toxicity
Effect, it is thus possible to have protective effect to chemical damage.
Taurine is a kind of free amino acid being widely present in humans and animals body, has the work of anti-lipid peroxidation
With.Taurine is widely used in as food additives in food industry.Experimental study proves it to liver caused by carbon tetrachloride
Damage, alcoholic liver injury and use in medicament-induced hepatotoxicity damage have protective effect, are a kind of good chemical damage protective agents.
In the tablet, contain per 100g:General flavone (in terms of rutin) 3.56g has relatively good control to chemical damage
Therapeutic effect.
It should be noted that herein, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any this practical relationship or sequence.Moreover, term " comprising ", "comprising" or its any other variant are intended to
Non-exclusive inclusion, so that process, method, article or equipment including a series of elements not only will including those
Element, but also including other elements that are not explicitly listed or further include as this process, method, article or equipment
Intrinsic element.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (7)
1. a kind of tablet for treating chemical damage, which is characterized in that the content of each substance includes ginkgo leaf 1100- in tablet
1200g, fruit of Chinese wolfberry 700-800g, vitamin E 5-7g, tea polyphenols 3-4g, taurine 20-25g, dextrin 240-260g, stearic acid
Magnesium 4-6g.
2. a kind of tablet for treating chemical damage according to claim 1, which is characterized in that its production technology is specific
Include the following steps:
The arrangement of step 1, the fruit of Chinese wolfberry and ginkgo leaf processes:Staff puts the fruit of Chinese wolfberry on sorting table, removes medicinal material by hand
In the impurity such as contained sawdust, sandstone and mould lose product etc.;The fruit of Chinese wolfberry after selection is put on medicine-washing machine, WATER-WASHING METHOD washes medicinal material dry
Only;Ginkgo leaf, which is put in rinse bath, to be rinsed, dries;Medicinal material after cleaning is put heated-air circulation oven to dry in time, drying temperature control
System is at 70~80 DEG C;The fruit of Chinese wolfberry after drying is carried out coarse crushing in Roughpulverizer;The independent coarse crushing of ginkgo leaf;By ginkgo leaf
It is spare after coarse powder drying;Calculated yield, yield spectra 90~98%;
Step 2, raw material extraction:Choosing ginkgo leaf coarse powder 450kg adds 10 times of 80% ethyl alcohol to impregnate 1 hour, and refluxing extraction 2 is small
When, it puts to room temperature, filtering, the dregs of a decoction add 8 times of 80% alcohol reflux to extract 2 hours again, put to room temperature, the dregs of a decoction are through two-stage centrifugal machine
Separation discards, and filtrate heating is boiled, distillation to no alcohol taste;Distill liquid condensing, recycling ethyl alcohol;Fruit of Chinese wolfberry coarse powder 300kg is chosen to add
10 times of water impregnate 30 minutes, refluxing extraction 2 hours, put to room temperature, filtering, and the dregs of a decoction add 8 times of water refluxing extractions 2 hours again, put to
Room temperature, the dregs of a decoction are discarded through the separation of two-stage centrifugal machine, merging more than extracting solution, with hypervelocity disc centrifuge decontamination;Filtrate is put
Fluid reservoir;
Step 3, filtrate concentration:The filtrate extracted in step 2 is pumped into Three-effect concentration device, pays attention to controlling technological parameter;One effect:
0.08~0.09Mpa of vapour pressure, 0.03~0.04Mpa of vacuum degree, 65~70 DEG C of temperature;Two effects:Vapour pressure 0.08~
0.09Mpa, 0.05~0.06Mpa of vacuum degree, 60~65 DEG C of temperature;Triple effect:0.08~0.09Mpa of vapour pressure, vacuum degree 0.07
50~55 DEG C of~0.08Mpa, temperature;When concentration cannot recycle, the liquid in two effects, triple effect is all focused in an effect
It is concentrated, concentrate proportion is measured in 65~70 DEG C of temperature, when proportion reaches 1.10~1.15, will be concentrated with gear pump
Liquid pump enters spherical concentrator and is concentrated, and concentrate proportion is measured in 55~60 DEG C of temperature, when proportion reaches 1.35~1.40
When, dispensing valve is opened, is put into the cleaning container that clean area is made ready beforehand for, weighs the weight of thick paste, the volume range of thick paste
24~28% for crude drug amount;
Step 4, thick paste vacuum drying:The thick paste prepared in step 3 is tiled in stainless steel disc, thickness is in 3~5cm, filling
The stainless steel disc of thick paste is put in vacuum drying chamber, is dried to moisture 3~5%, dry cream is fitted into bag, is tightened pocket and is weighed;It receives
Rate range 44~48%;
Step 5, dry cream crush:The dry cream prepared in step 4 is poured into pulverizer, starts pulverizer and dry cream was ground into 80
After crushing, dried cream powder is packed into clean polybag for~100 targeted fine powders, tightens mouth, the clean woven bag of housing,
Mouth is tightened, simultaneously calculated yield of weighing;Yield spectra 95~98%;It fills in and asks verification certificate, detection character, discriminating and hygiene;
Step 6, raw material mixing:Vitamin E, tea polyphenols, taurine are mixed by formula rate, with the omnipotent crushing of WF-180B types
Machine crushes, revolution 4000rpm;Pay attention to answering first starting device, then above-mentioned slightly mixed raw material is uniformly added into hopper;Sieving is same with crushing
Step is completed;Cyclic annular sieve plate eyelet control mesh number is 150 mesh;Above-mentioned mixed powder 14kg, dried cream powder 84kg, dextrin 100kg are placed in V-type
In mixing machine, inventory is about the 30% of mixing machine capacity, when adjusting device rotating speed reaches the 30~40% of critical speed, continuously
About 15min is operated, is stopped to get uniformly mixed raw material;
Step 7, granulation:Raw material mixed in step 6 is added in into ethyl alcohol softwood;The dosage of ethyl alcohol is generally the 8 of dry material
~12%, specific dosage, which should control, is adding the mixed material of ethyl alcohol to be convenient for subject to granulation;Softwood puts wet mixing pelletizer
In, start the main stirring button of wet mixing pelletizer, motor is closed in operation after five minutes, starts cutter motor, and selection stirring is fast
Shelves and the slow shelves of cutting are pelletized 3 minutes;80~100 μm of cumulative distribution >=90% of granularity, about 400 μm of average particle size (grain size);
Step 8, particle drying:Wet granular in step 7 is equably split in stainless steel baking pan, drying vehicle is pushed into and is dried
Room when particle is dried to water content 3~5%, takes out dried particle;
Step 9, whole grain:14 mesh sieve is installed, starts pelletizing machine, dry particl dried in step 8 is sequentially added, whole grain finishes
After weigh, calculated yield carries out material balance;
Step 10 is always mixed:Conforming particle is put Mixers with Multi-direction Movement, adds in magnesium stearate 2kg, starts mixing machine and mixes 15 points
Clock shuts down discharging, fills in and ask verification certificate;
Step 11, tabletting:Particle is after the assay was approved using GZPKI32 type stamping machine tablettings, and 32 punchings, adjustment stamping pressure is about
30KN makes every piece weight for 0.5g, checks that average piece weight is primary, and makes a record every 20 minutes;
Step 12 takes up:Piece is fitted into together with cloth bag in clean stainless steel barrel, intermediate station is sent into sealing;Bucket wall is labelled,
Indicate the name of an article, specification, lot number and total quantity, date of manufacture, operator;
Step 13, inner packing:It is dispensed by 60 every bottle, theoretical yield 400,000, continuous production yield answers >=95%;
Step 14, outer packing:Specification:0.5g/ piece × 60 piece/bottle × 12 bottles/middle box × 20 in box/part;Packing instructions:Tab end
Just, lot number is clear;Packaging material print content meets national relevant regulations, and clear writing is errorless;Vanning is tight, securely, batch
It is number clear, there is work certificate;
Step 15 is examined and is put in storage:It is examined according to company standard, qualification can be sold into library.
3. a kind of tablet for treating chemical damage according to claim 2, which is characterized in that in step 2 two-stage from
The rotating speed of scheming is 800~1000 turns/min, and the rotating speed for the disc centrifuge that exceeds the speed limit is 5000 turns/min.
A kind of 4. tablet for treating chemical damage according to claim 2, which is characterized in that drying box in step 4
65~70 DEG C of drying temperature;0.07~0.08Mpa of vacuum degree.
5. a kind of tablet for treating chemical damage according to claim 1, which is characterized in that the tea polyphenols are
TP-I types, purity >=90%.
A kind of 6. tablet for treating chemical damage according to claim 2, which is characterized in that ethyl alcohol in step 7
A concentration of 60~80%.
A kind of 7. tablet for treating chemical damage according to claim 2, which is characterized in that drying chamber in step 8
65~70 DEG C of drying temperature.
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CN201810153969.0A CN108175807A (en) | 2018-02-22 | 2018-02-22 | A kind of tablet for treating chemical damage |
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CN201810153969.0A CN108175807A (en) | 2018-02-22 | 2018-02-22 | A kind of tablet for treating chemical damage |
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Family
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Citations (3)
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CN102669667A (en) * | 2012-05-25 | 2012-09-19 | 北京三奇本草医药技术有限公司 | Health food with dual functions of protecting liver and adjusting blood fat and preparation method thereof |
CN102711780A (en) * | 2009-10-28 | 2012-10-03 | Modutech公司 | Preparation comprising amino acids and plants and its activity in alcohol detoxification |
CN104509763A (en) * | 2013-09-27 | 2015-04-15 | 青岛畅绿生物研究所 | Water lily pollen and chitosan capsule for neutralizing the effect of alcohol |
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2018
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CN102711780A (en) * | 2009-10-28 | 2012-10-03 | Modutech公司 | Preparation comprising amino acids and plants and its activity in alcohol detoxification |
CN102669667A (en) * | 2012-05-25 | 2012-09-19 | 北京三奇本草医药技术有限公司 | Health food with dual functions of protecting liver and adjusting blood fat and preparation method thereof |
CN104509763A (en) * | 2013-09-27 | 2015-04-15 | 青岛畅绿生物研究所 | Water lily pollen and chitosan capsule for neutralizing the effect of alcohol |
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Title |
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