CN108175797A - A kind of external application Chinese medicine agent for treating eye surface diseases and preparation method thereof - Google Patents
A kind of external application Chinese medicine agent for treating eye surface diseases and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to eye external used medicine technical fields, and in particular to a kind of external application Chinese medicine agent for treating eye surface diseases and preparation method thereof.The external application Chinese medicine agent of the treatment eye surface diseases is made of the raw material of following parts by weight：8~10 parts of Radix Angelicae Sinensis, 15~20 parts of long-noded pit viper, 10~15 parts of cassia seed, 20~30 parts of Radix Isatidis, 15~20 parts of cordate houttuynia.The present invention is only used cooperatively with 5 taste medicinal materials using drug matching principle, develops a kind of Chinese medicine preparation that can treat bacillary eye disease and viral eye disease simultaneously, and drug effective percentage is up to more than 90%.The present invention also provides a kind of preparation methods for treating eye surface diseases, have impregnated medicinal material using sodium bicarbonate solution, medicinal material is modified, and accelerate the dissolution of active material in medicinal material.
Description
Technical field
The invention belongs to eye external used medicine technical fields, and in particular to a kind of external application Chinese medicine agent for treating eye surface diseases and
Preparation method.
Background technology
Ocular infectious diseases is ophthalmology outpatient service common disease and frequently-occurring disease, wherein with bacillary and viral conjunctivokeratitis
Disease is the most common, such as staphylococcus aureus membranous conjunctivitis, gonococcal conjunctivitis, adenovirus kerato-conjuntivitis, herpes simplex virus
Property keratitis etc..Bacterial keratitis is the keratitis as caused by sensitive pathogenic bacteria, in the prior art, bacillary conjunctiva cornea
It is scorching to use the antibacterial eye drops of local frequency point sensitivity first once clarifying a diagnosis, secondly inhibition inflammation, needs to carry out when necessary
Operative treatment.Clinically common antibacterial ocular fluid has quinolones, cephalo-type, aminoglycoside, macrolides etc., such drug
Have the characteristics that broad spectrum activity, sensibility are high, tissue penetration is strong.But the antibiotic medicines such as above-mentioned quinolones, which are used for a long time, can make carefully
Bacterium generates drug resistance, and antibiotic is poor to the inhibiting effect of virus.Viral conjunctivokeratitis is by one or more causes
Caused by virus, currently used drug is aciclovir eye drop and Ganciclovir ocular fluid, but both medicines are to pass through
The synthesis of viral DNA is inhibited to reach antivirus action, but prolonged application can cause conjunctival epithelium to damage.
The traditional Chinese medical science is the traditional medical mode in China, because of its Small side effects, can be improved from body whole body, it is simultaneous to reach sample
The effect controlled is still common drug so far.Therefore, if exploitation one kind can treat bacillary and viral conjunctiva cornea simultaneously
The Chinese medicine of inflammation, it is possible to reduce the use of antibiotic and Western medicine avoids the generation of microorganism drug resistance.
Invention content
The object of the present invention is to provide a kind of external application Chinese medicine agent for treating eye surface diseases and preparation method thereof, can control simultaneously
The Chinese medicine of bacillary and viral eye surface diseases is treated, the use of antibiotic will be reduced, avoid the generation of microorganism drug resistance.
A kind of external application Chinese medicine agent for treating eye surface diseases provided by the invention, is made of the raw material of following parts by weight：Radix Angelicae Sinensis 8
~10 parts, 15~20 parts of long-noded pit viper, 10~15 parts of cassia seed, 20~30 parts of Radix Isatidis, 15~20 parts of cordate houttuynia.
Preferably, it in the external application Chinese medicine agent of above-mentioned treatment eye surface diseases, is made of the raw material of following parts by weight：8 parts of Radix Angelicae Sinensis,
15 parts of long-noded pit viper, 15 parts of cassia seed, 20 parts of Radix Isatidis, 20 parts of cordate houttuynia.
The present invention also provides a kind of preparation method of the external application Chinese medicine agent of above-mentioned treatment eye surface diseases, including following step
Suddenly：
S1 weighs each raw material by following weight：8~10 parts of Radix Angelicae Sinensis, 15~20 parts of long-noded pit viper, cassia seed 10~15
Part, 20~30 parts of Radix Isatidis, 15~20 parts of cordate houttuynia；
S2, each raw material that S1 is weighed mix, and are added in into obtained mixture and are equivalent to each 10 times of raw material gross weight
The sodium bicarbonate solution of 0.6g/100ml impregnates 2d, then boils 10~15min, filters out the dregs of a decoction, collects filtrate；
S3 adds in the hydrochloric acid solution of 0.05mol/l to the filtrate of S2, adjusts pH to 7.0, obtain neutral liquid；
S4, after the neutral liquid of S3 is boiled 5~10min, decolorization obtains decoloration liquid；
S5 by the decoloration liquid rotary evaporation of S4 to volume is the sodium bicarbonate solution volume 1/10, obtains medical treatment
The external application Chinese medicine agent of eye surface diseases.
Preferably, in the preparation method of the external application Chinese medicine agent of above-mentioned treatment eye surface diseases, the decolorization uses polarity
Adsorbent and non-polar adsorbent decolourize, and the polar adsorbent is silica gel, the non-polar adsorbent for activated carbon or
Person's diatomite.
Preferably, in the preparation method of the external application Chinese medicine agent of above-mentioned treatment eye surface diseases, in S4, neutral liquid boils 5~
It after 10min, decolourizes followed by non-polar adsorbent column and polar adsorbent column, wherein the diameter of non-polar adsorbent column
It is highly 50cm for 50cm；A diameter of 40cm of polar adsorbent column is highly 60cm.
Compared with prior art, external application Chinese medicine agent for the treatment of eye surface diseases provided by the invention and preparation method thereof, has
Following advantageous effect：
1st, it is promoting blood circulation, analgesic in the main function of the Radix Angelicae Sinensis described in Chinese Pharmacopoeia；The main function of long-noded pit viper is heat-clearing
Removing toxic substances, antibacterial anti-inflammatory；The main function of cassia seed is blood pressure lowering, clears liver and improve vision, and the main function of Radix Isatidis is antiviral, heat-clearing
Removing toxic substances, the main function of cordate houttuynia is clearing heat and detoxicating.The present invention is only used cooperatively with 5 taste medicinal materials, is opened using drug matching principle
A kind of Chinese medicine preparation that can treat bacillary eye disease and viral eye disease simultaneously is sent out, drug effective percentage will subtract up to more than 90%
The use of few antibiotic, avoids the generation of microorganism drug resistance.
2nd, preparation method of the invention has first impregnated medicinal material using sodium bicarbonate solution, and medicinal material is modified, and accelerates medicine
Then the dissolution of active material in material is neutralized to neutrality through hydrochloric acid solution, sodium bicarbonate and hydrochloric acid reaction generation sodium chloride, water and
Carbon dioxide, wherein carbon dioxide are overflowed through follow-up boiling stage, are remained in medicament as sodium ion necessary to body, medication
When be absorbed by organisms.In preparation method, polar adsorbent and non-polar adsorbent are used in conjunction with, it is adsorbable fall polarity pigment and non-
Polarity pigment, while silica gel, activated carbon and diatomite are also used as filtration adjuvant use.
Specific embodiment
The present invention is described in detail With reference to embodiment, it is to be understood that protection scope of the present invention is simultaneously
It is not restricted by specific implementation.The test method of actual conditions is not specified in the following example, usually according to normal condition
Operation, the material source being not specified is commercially available, due to not being related to inventive point, therefore its step is not described in detail.
The present invention provides a kind of external application Chinese medicine agent for treating eye surface diseases, are made of the raw material of following parts by weight：Radix Angelicae Sinensis 8
~10 parts, 15~20 parts of long-noded pit viper, 10~15 parts of cassia seed, 20~30 parts of Radix Isatidis, 15~20 parts of cordate houttuynia.
Based on same inventive concept, the present invention also provides a kind of external application Chinese medicine agent of the treatment eye surface diseases
Preparation method includes the following steps：
S1 weighs each raw material by following weight：8~10 parts of Radix Angelicae Sinensis, 15~20 parts of long-noded pit viper, cassia seed 10~15
Part, 20~30 parts of Radix Isatidis, 15~20 parts of cordate houttuynia；
S2, each raw material that S1 is weighed mix, and are added in into obtained mixture and are equivalent to each 10 times of raw material gross weight
The sodium bicarbonate solution of 0.6g/100ml impregnates 2d, then boils 10~15min, filters out the dregs of a decoction, collects filtrate；
S3 adds in the hydrochloric acid solution of 0.05mol/l to the filtrate of S2, adjusts pH to 7.0, obtain neutral liquid；
S4, after the neutral liquid of S3 is boiled 5~10min, decolorization obtains decoloration liquid；
S5 by the decoloration liquid rotary evaporation of S4 to volume is the sodium bicarbonate solution volume 1/10, obtains medical treatment
The external application Chinese medicine agent of eye surface diseases.
Wherein, the decolorization is decolourized using polar adsorbent and non-polar adsorbent, the polar adsorbent
For silica gel, the non-polar adsorbent is activated carbon or diatomite.After neutral liquid boils 5~10min, followed by non-pole
Property adsorbent column and polar adsorbent column decolourize.
It should be noted that extending the shelf life to reach, 1 ‰ preservative after Chinese medicine is prepared, can be added.
The embodiment of the external application Chinese medicine agent of some present invention treatment eye surface diseases is set forth below.
Embodiment 1
A kind of external application Chinese medicine agent for treating eye surface diseases, is made of the raw material of following parts by weight：8 parts of Radix Angelicae Sinensis, long-noded pit viper 15
Part, 15 parts of cassia seed, 20 parts of Radix Isatidis, 20 parts of cordate houttuynia.
Embodiment 2
A kind of external application Chinese medicine agent for treating eye surface diseases, is made of the raw material of following parts by weight：10 parts of Radix Angelicae Sinensis, long-noded pit viper 20
Part, 10 parts of cassia seed, 30 parts of Radix Isatidis, 15 parts of cordate houttuynia.
Embodiment 3
A kind of external application Chinese medicine agent for treating eye surface diseases, is made of the raw material of following parts by weight：9 parts of Radix Angelicae Sinensis, long-noded pit viper 18
Part, 12 parts of cassia seed, 25 parts of Radix Isatidis, 16 parts of cordate houttuynia.
Embodiment 4
A kind of external application Chinese medicine agent for treating eye surface diseases, is made of the raw material of following parts by weight：8 parts of Radix Angelicae Sinensis, long-noded pit viper 19
Part, 11 parts of cassia seed, 22 parts of Radix Isatidis, 18 parts of cordate houttuynia.
Embodiment 5
A kind of external application Chinese medicine agent for treating eye surface diseases, is made of the raw material of following parts by weight：10 parts of Radix Angelicae Sinensis, long-noded pit viper 15
Part, 14 parts of cassia seed, 28 parts of Radix Isatidis, 16 parts of cordate houttuynia.
The preparation side of the external application Chinese medicine agent of some present invention treatment eye surface diseases is enumerated by taking the formula of embodiment 1 as an example below
Method embodiment.
Embodiment 6
A kind of preparation method of external application Chinese medicine agent for treating eye surface diseases, includes the following steps：
S1 weighs each raw material by following weight：8 parts of Radix Angelicae Sinensis, 15 parts of long-noded pit viper, 15 parts of cassia seed, Radix Isatidis 20
Part, 20 parts of cordate houttuynia；
S2, each raw material that S1 is weighed mix, and are added in into obtained mixture and are equivalent to each 10 times of raw material gross weight
The sodium bicarbonate solution of 0.6g/100ml impregnates 2d, is stirred 3 times during immersion, then with 10min is boiled, filter out the dregs of a decoction, receives
Collect filtrate；
S3 adds in the hydrochloric acid solution of 0.05mol/l to the filtrate of S2, adjusts pH to 7.0, obtain neutral liquid；
S4, after the neutral liquid of S3 is boiled 5min, decolorization while hot obtains decoloration liquid；
Decolorization is decolourized using polar adsorbent and non-polar adsorbent, and the polar adsorbent is silica gel, institute
Non-polar adsorbent is stated as activated carbon；After neutral liquid boils 5min, followed by non-polar adsorbent column and polar adsorbent
Column decolourizes, wherein a diameter of 50cm of non-polar adsorbent column, is highly 50cm, flow velocity 10L/min；Polar adsorbent
A diameter of 40cm of column is highly 60cm, flow velocity 10L/min；
S5 by the decoloration liquid rotary evaporation of S4 to volume is the sodium bicarbonate solution volume 1/10, obtains medical treatment
The external application Chinese medicine agent of eye surface diseases.
Embodiment 7
A kind of preparation method of external application Chinese medicine agent for treating eye surface diseases, includes the following steps：
S1 weighs each raw material by following weight：8 parts of Radix Angelicae Sinensis, 15 parts of long-noded pit viper, 15 parts of cassia seed, Radix Isatidis 20
Part, 20 parts of cordate houttuynia；
S2, each raw material that S1 is weighed mix, and are added in into obtained mixture and are equivalent to each 10 times of raw material gross weight
The sodium bicarbonate solution of 0.6g/100ml impregnates 2d, is stirred 4 times during immersion, then with 15min is boiled, filter out the dregs of a decoction, receives
Collect filtrate；
S3 adds in the hydrochloric acid solution of 0.05mol/l to the filtrate of S2, adjusts pH to 7.0, obtain neutral liquid；
S4, after the neutral liquid of S3 is boiled 10min, decolorization while hot obtains decoloration liquid；
Decolorization is decolourized using polar adsorbent and non-polar adsorbent, and the polar adsorbent is silica gel, institute
Non-polar adsorbent is stated as activated carbon；After neutral liquid boils 10min, followed by non-polar adsorbent column and polar adsorbent
Column decolourizes, wherein a diameter of 50cm of non-polar adsorbent column, is highly 50cm, flow velocity 10L/min；Polar adsorbent
A diameter of 40cm of column is highly 60cm, flow velocity 10L/min；
S5 by the decoloration liquid rotary evaporation of S4 to volume is the sodium bicarbonate solution volume 1/10, obtains medical treatment
The external application Chinese medicine agent of eye surface diseases.
Embodiment 8
A kind of preparation method of external application Chinese medicine agent for treating eye surface diseases, includes the following steps：
S1 weighs each raw material by following weight：8 parts of Radix Angelicae Sinensis, 15 parts of long-noded pit viper, 15 parts of cassia seed, Radix Isatidis 20
Part, 20 parts of cordate houttuynia；
S2, each raw material that S1 is weighed mix, and are added in into obtained mixture and are equivalent to each 10 times of raw material gross weight
The sodium bicarbonate solution of 0.6g/100ml impregnates 2d, is stirred 2 times during immersion, then with 12min is boiled, filter out the dregs of a decoction, receives
Collect filtrate；
S3 adds in the hydrochloric acid solution of 0.05mol/l to the filtrate of S2, adjusts pH to 7.0, obtain neutral liquid；
S4, after the neutral liquid of S3 is boiled 8min, decolorization while hot obtains decoloration liquid；
Decolorization polar adsorbent and non-polar adsorbent decolourize, and the polar adsorbent is silica gel, described non-
Polar adsorbent is diatomite；After neutral liquid boils 8min, the flame filter press filtering for being sequentially arranged with diatomite and silica gel is de-
Color, diatomite and silica gel are both decolorising agent and filter aid.
S5 by the decoloration liquid rotary evaporation of S4 to volume is the sodium bicarbonate solution volume 1/10, obtains medical treatment
The external application Chinese medicine agent of eye surface diseases.
Embodiment 9
A kind of preparation method (formula of embodiment 1) of external application Chinese medicine agent for treating eye surface diseases, includes the following steps：
S (1) weighs each raw material by following weight：8 parts of Radix Angelicae Sinensis, 15 parts of long-noded pit viper, 15 parts of cassia seed, Radix Isatidis
20 parts, 20 parts of cordate houttuynia；
S (2), each raw material that S (1) is weighed mix, and are added in into obtained mixture and are equivalent to each raw material gross weight 10
In water again, 2d is impregnated, is stirred 3 times during immersion, then with 10min is boiled, filtered out the dregs of a decoction, collect filtrate；
S (3), after the neutral liquid of S (2) is boiled 5min, decolorization while hot obtains decoloration liquid；
Decolorization is decolourized using polar adsorbent and non-polar adsorbent, and the polar adsorbent is silica gel, institute
Non-polar adsorbent is stated as activated carbon；After neutral liquid boils 5min, followed by non-polar adsorbent column and polar adsorbent
Column decolourizes, wherein a diameter of 50cm of non-polar adsorbent column, is highly 50cm, flow velocity 10L/min；Polar adsorbent
A diameter of 40cm of column is highly 60cm, flow velocity 10L/min；
S5, by 1/10 of the decoloration liquid rotary evaporation of S4 to volume for water volume described in S (2), obtain medical treatment ocular
The external application Chinese medicine agent of disease.
Below by taking the formula of Examples 1 to 5 as an example, illustrate the effect of external application Chinese medicine agent of the present invention.
First, bacteriostatic experiment
Using staphylococcus aureus, staphylococcus epidermis, diphtheroid as experimental strain, above-mentioned bacterial strains are enough from micro-
Biological deposits center CGMCC.The culture solution of staphylococcus aureus, staphylococcus epidermis, diphtheroid is prepared respectively, is diluted
Cell concentration is to 106Cfu/ml, by the filter paper dick of a diameter of 0.5cm in Chinese medicine (each grouping uses different Chinese medicines)
Middle immersion 10min；Prepare beef extract-peptone tablet, and it is sterile under the conditions of difference is coated on beef extract-peptone tablet respectively
The culture solution of staphylococcus aureus, staphylococcus epidermis, diphtheroid is prepared, is later placed on the filter paper impregnated flat
Plate center, 37 DEG C are cultivated 14h, measure the size of inhibition zone.
Wherein, the Chinese medicine of Examples 1 to 5 group is using the formula of Examples 1 to 5 and the preparation method of embodiment 6,
The Chinese medicine for compareing 1 group compares 2 groups using 35mg/ using the formula of embodiment 1 and the preparation method of embodiment 9
100ml penicillin solutions.The results are shown in Table 1.
The inhibition zone size of the different Chinese medicines of table 1
Table 1 the results show that using Chinese medicine made of the formula of Examples 1 to 5 and the preparation method of embodiment 6 to gold
Staphylococcus aureus, staphylococcus epidermis, the fungistatic effect of diphtheroid are suitable with 35mg/100ml penicillin solution effects,
But 1 group of fungistatic effect of control is poor.The reason is that the preparation method of embodiment 6 has first impregnated medicinal material using sodium bicarbonate solution,
Medicinal material is modified, accelerates the dissolution of active material in medicinal material, is then neutralized to neutrality through hydrochloric acid solution.1 group is compareed to have no
Sodium bicarbonate solution soaking step, therefore fungistatic effect is poor.
2nd, to the influence of rabbit eyes Bulbar conjunctiva microcirculation
Using rabbit eye conjunctiva capilary fluorimetry, rabbit 30 is selected, male and female partition board, weight 1.8-2.5kg, with
Machine is divided into 3 groups, wherein 1 group of gavage Chinese medicine of embodiment, which is to wear into 100 after being weighed with each medicinal material of the formula of embodiment 1
Purpose medicinal powder, gavage amount 1.5g/kg, successive administration 7 days；2 groups of gavage Chinese medicines of embodiment, the Chinese medicine are with the formula of embodiment 2
Each medicinal material weigh after wear into the medicinal powder of 100 mesh, gavage amount 1.5g/kg, successive administration 7 days；The quality physiology such as control group gavage
Brine, successive administration 7 days.1h after last gavage drug, to the fluorescein sodium normal saline solution of family's rabbit ear vein injection 10%
1ml/kg (is equivalent to and has injected fluorescein 100mg/kg), and the time of fluorescence occurs in record rabbit eye conjunctiva, the results show that implementing
There are fluorescence times for 7.58s (average value of 10 rabbit) in 1 group of example, and 2 groups of embodiment fluorescence times occurs for 7.70s (10
The average value of rabbit), there are fluorescence times for 12.79s (average value of 10 rabbit) in control group, the results showed that 1 He of embodiment
2 groups of embodiment substantially speeds up rabbit eyes Bulbar conjunctiva microcirculation blood flow, improves supply of blood flow, there are significant difference (P with control group<
0.05)。
3rd, clinical case
Shen, man, 32 years old, clinical diagnosis was staphylococcus aureus membranous conjunctivitis, with staphylococcic blear-eye etc.
Symptom, using the external application Chinese medicine agent of embodiment 1, usage is 4 times a day, 3 drip every time, and symptom disappears after 1 week, gets well, nothing
Side effect.
Lee, female, 29 years old, clinical diagnosis was gonococcal conjunctivitis, and using the external application Chinese medicine agent of embodiment 1, usage is every
Hour is primary, every time 4 drop, and symptom disappears after 4 days, gets well, without side-effects.
Shangguan, man, 33 years old, clinical diagnosis was adenovirus kerato-conjuntivitis, using the external application Chinese medicine agent of embodiment 1, was used
Method is 4 times a day, 3 drip every time, and symptom disappears after 10 days, gets well, without side-effects.
Xiao, female, 51 years old, clinical diagnosis was herpes simplex keratitis, using the external application Chinese medicine agent of embodiment 1,
Usage is 4 times a day, 3 drip, while (each parts by weight represent 1 gram, for example 8 parts of Radix Angelicae Sinensis is exactly to claim with the formula of embodiment 1 every time
Take 8 grams of Radix Angelicae Sinensis) routinely prescription method decoction, filtering, Chinese medicine liquid is taken, 3 times a day, each 100ml, symptom disappears after 6 days,
It gets well, it is without side-effects.
Above-mentioned clinical case shows that Chinese medicine can be treated effectively made of pharmaceutical formulation provided by the invention and preparation method
Viral or bacillary eye surface diseases.In addition, we choose 100 herpes simplex keratitis patients, reference is above-mentioned
The application method medication of Xiao, curative effect is observed after 1 week, wherein 80 people fully recover, 10 people obtain effectively alleviating (irritated eyes base
Originally completely disappear, fluorescent staining is dotted or dendroid corneal epithelium lesion at polish a little), the effective percentage of Chinese medicine is
90%.
It should be noted that it is said in claims and specification if being related to numberical range in the present invention
It is bright feasible in the numberical range, including endpoint value, although preferred embodiments of the present invention have been described, but in the art
Technical staff once knows basic creative concept, then additional changes and modifications may be made to these embodiments.So institute
Attached claim is intended to be construed to include preferred embodiment and falls into all change and modification of the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
God and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (5)
1. a kind of external application Chinese medicine agent for treating eye surface diseases, which is characterized in that be made of the raw material of following parts by weight：Radix Angelicae Sinensis 8~
10 parts, 15~20 parts of long-noded pit viper, 10~15 parts of cassia seed, 20~30 parts of Radix Isatidis, 15~20 parts of cordate houttuynia.
2. the external application Chinese medicine agent for the treatment of eye surface diseases according to claim 1, which is characterized in that by the original of following parts by weight
Material composition：8 parts of Radix Angelicae Sinensis, 15 parts of long-noded pit viper, 15 parts of cassia seed, 20 parts of Radix Isatidis, 20 parts of cordate houttuynia.
3. it is a kind of it is described in claim 1 treatment eye surface diseases external application Chinese medicine agent preparation method, which is characterized in that including with
Lower step：
S1 weighs each raw material by following weight：8~10 parts of Radix Angelicae Sinensis, 15~20 parts of long-noded pit viper, 10~15 parts of cassia seed,
20~30 parts of Radix Isatidis, 15~20 parts of cordate houttuynia；
S2, each raw material that S1 is weighed mix, and the 0.6g/ for being equivalent to each 10 times of raw material gross weight is added in into obtained mixture
The sodium bicarbonate solution of 100ml impregnates 2d, then boils 10~15min, filters out the dregs of a decoction, collects filtrate；
S3 adds in the hydrochloric acid solution of 0.05mol/l to the filtrate of S2, adjusts pH to 7.0, obtain neutral liquid；
S4, after the neutral liquid of S3 is boiled 5~10min, decolorization obtains decoloration liquid；
S5, by the decoloration liquid rotary evaporation of S4 to volume is the sodium bicarbonate solution volume 1/10, obtain medical treatment ocular
The external application Chinese medicine agent of disease.
4. the preparation method of the external application Chinese medicine agent for the treatment of eye surface diseases according to claim 3, which is characterized in that described de-
Color processing is decolourized using polar adsorbent and non-polar adsorbent, and the polar adsorbent is silica gel, and the nonpolarity is inhaled
Attached dose is activated carbon or diatomite.
5. the preparation method of the external application Chinese medicine agent for the treatment of eye surface diseases according to claim 4, which is characterized in that in S4,
It after neutral liquid boils 5~10min, decolourizes followed by non-polar adsorbent column and polar adsorbent column, wherein non-pole
A diameter of 50cm of property adsorbent column, is highly 50cm；A diameter of 40cm of polar adsorbent column is highly 60cm.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965877A (en) * | 2006-11-06 | 2007-05-23 | 赵因 | Chinese medicinal eye drop for treating bacteria and virus infected conjunctivitis |
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2018
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965877A (en) * | 2006-11-06 | 2007-05-23 | 赵因 | Chinese medicinal eye drop for treating bacteria and virus infected conjunctivitis |
Non-Patent Citations (2)
| Title |
|---|
| 戴丽彬等: "鱼腥草注射液与板蓝根冲剂治疗流行性角结膜炎 ", 《中国民间疗法》 * |
| 朱晓林: "角膜炎中医文献及证治规律研究", 《中国博士学位论文全文数据库 卫生医药科技辑》 * |
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