CN108175736A - Gargle and preparation method thereof - Google Patents
Gargle and preparation method thereof Download PDFInfo
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- CN108175736A CN108175736A CN201810058505.1A CN201810058505A CN108175736A CN 108175736 A CN108175736 A CN 108175736A CN 201810058505 A CN201810058505 A CN 201810058505A CN 108175736 A CN108175736 A CN 108175736A
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- gargle
- green tea
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- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 60
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 53
- 239000000341 volatile oil Substances 0.000 claims abstract description 36
- 244000269722 Thea sinensis Species 0.000 claims abstract description 35
- 235000009569 green tea Nutrition 0.000 claims abstract description 34
- 239000000284 extract Substances 0.000 claims abstract description 31
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 20
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000012907 honey Nutrition 0.000 claims abstract description 20
- 229940041616 menthol Drugs 0.000 claims abstract description 20
- 235000010447 xylitol Nutrition 0.000 claims abstract description 19
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000811 xylitol Substances 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 17
- 229960002675 xylitol Drugs 0.000 claims abstract description 17
- 239000008213 purified water Substances 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 8
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims description 36
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 36
- 241000628997 Flos Species 0.000 claims description 27
- 239000006286 aqueous extract Substances 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 16
- AXPZIVKEZRHGAS-UHFFFAOYSA-N 3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one Chemical compound [O-][N+](=O)C1=CC=CC=C1OCC1OC(=O)C(CC=2C=CC=CC=2)C1 AXPZIVKEZRHGAS-UHFFFAOYSA-N 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 8
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 7
- -1 1 part of 1 Chemical compound 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims description 4
- 235000011613 Pinus brutia Nutrition 0.000 claims description 4
- 241000018646 Pinus brutia Species 0.000 claims description 4
- 239000011269 tar Substances 0.000 claims description 4
- 240000003553 Leptospermum scoparium Species 0.000 claims 5
- 241000366182 Melaleuca alternifolia Species 0.000 abstract description 32
- 230000002949 hemolytic effect Effects 0.000 abstract description 17
- 241000194017 Streptococcus Species 0.000 abstract description 16
- 210000000214 mouth Anatomy 0.000 abstract description 10
- 239000000126 substance Substances 0.000 abstract description 10
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 abstract 2
- 235000019437 butane-1,3-diol Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 10
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 235000019441 ethanol Nutrition 0.000 description 7
- 244000052616 bacterial pathogen Species 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 208000030194 mouth disease Diseases 0.000 description 3
- 210000003800 pharynx Anatomy 0.000 description 3
- 239000003643 water by type Substances 0.000 description 3
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- UFLHIIWVXFIJGU-ARJAWSKDSA-N (Z)-hex-3-en-1-ol Chemical compound CC\C=C/CCO UFLHIIWVXFIJGU-ARJAWSKDSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 241000378467 Melaleuca Species 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 235000008075 Pistacia terebinthus Nutrition 0.000 description 1
- 240000006705 Pistacia terebinthus Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001775 anti-pathogenic effect Effects 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 235000011116 calcium hydroxide Nutrition 0.000 description 1
- 208000020670 canker sore Diseases 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000004130 lipolysis Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Birds (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Insects & Arthropods (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Husbandry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to the technical field of preparation of daily chemicals, and aims to provide a gargle and a preparation method thereof, wherein the gargle is prepared by mixing the following raw materials in parts by weight: 0.008-0.03 part of melaleuca alternifolia essential oil, 1-2 parts of green tea water extract, 0.008-0.02 part of honeysuckle water extract, 0.8-1.2 parts of citric acid, 1.2-1.8 parts of natural honey, 1.4-1.8 parts of xylitol, 0.008-0.02 part of menthol, 1 part of 1, 3-butanediol and 92.13-94.576 parts of purified water. The invention also provides a preparation method of the gargle. The gargle disclosed by the invention is safe in formula and can effectively inhibit hemolytic streptococcus in oral cavity.
Description
Technical field
The present invention relates to chemical product preparing technical field, more particularly to a kind of gargle and preparation method thereof.
Background technology
At present, as air pollution is increasingly serious, due to the presence of all kinds of pollution factors in air, it has been born more and more
Superbacteria, meanwhile, diet kind is numerous and diverse, and health level is irregular, in addition environmental pollution caused by heavy industry, when no without
Carve the chance that intrusion human body is provided to bacterium, virus etc., the oral cavity not still respiratory system of the mankind and digestive system it is important
Composition position and the human organ directly contacted with environment, are inevitably influenced by external environment, such as common pharynx
Portion's disease --- pharyngitis and tonsillitis, mostly hemolytic streptococcus causes, and therefore, the cleaning ambient in oral cavity is kept very must
It will.
Gargle, also referred to as mouthwash, gargle etc., gargle is easy to use, saves the time, and does not need to particularly use
Tool, is very effective oral hygiene appliance.At present on the market, all kinds of gargles of oral environment is maintained to use irritation more
Learn substance, although good sterilization effect, simultaneously also to mucous membrane of mouth generate stimulation, in addition also have part pure natural or
Biological agent, although formula safety, Disinfection Effect is general, especially the Main Pathogenic Bacteria haemolysis to mouth disease or disease of pharynx
Property streptococcus killing effect is weaker.
Invention content
It is an object of the invention to overcome drawbacks described above, a kind of formula safety is provided and can effectively inhibit haemolysis in oral cavity
The streptococcic gargle of property, and the preparation method of the gargle is provided.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention is：
The present invention provides a kind of gargle, is mixed including following raw material：Narrow leaved tea tree essential oil 0.008~
0.03 part, 1~2 part of green tea Aqueous extracts, 0.008~0.02 part of water extract of flos lonicerae, 0.8~1.2 part of citric acid, natural honey
1.2~1.8 parts, 1.4~1.8 parts of xylitol, 0.008~0.02 part of menthol, 1 part of 1,3-BDO and purified water 92.13~
94.576 parts.
The present invention provides a kind of preparation method of gargle, includes the following steps：
Step 1：By the narrow leaved tea tree essential oil of 0.008~0.03 parts by weight and the menthol of 0.008~0.02 parts by weight
It is mixed with the 1,3-BDO of 1 parts by weight, obtains just mixed liquid；
Step 2：The citric acid of 0.8~1.2 parts by weight is added in into the purified water of 92.13~94.576 parts by weight, then
Sequentially added while stirring the xylitols of 1.4~1.8 parts by weight, 1~2 parts by weight it is green tea Aqueous extracts, 0.008~
Water extract of flos lonicerae, step 1 gained of 0.02 parts by weight just mix liquid and the natural honey of 1.2~1.8 parts by weight, obtain target production
Object.
The beneficial effects of the present invention are：The present invention is according to the characteristics of oral environment, mouth disease and disease of pharynx are main
The biochemical character of pathogenic bacteria hemolytic streptococcus, by narrow leaved tea tree essential oil, green tea Aqueous extracts, water extract of flos lonicerae, citric acid,
Natural honey, xylitol and menthol can effectively inhibit containing for hemolytic streptococcus in suitable ratio compatibility to be mixed
Gargarism, according to detection, gargle of the invention reaches more than 99% to the bacteriostasis rate of hemolytic streptococcus, the suppression to Escherichia coli
Bacterium rate is up to more than 91%；The gargle of the present invention, mildly, non-stimulated without irritating chemical substance, adult is suitable with children
With.
Specific embodiment
In order to describe the technical content, the structural feature, the achieved object and the effect of this invention in detail, below in conjunction with embodiment
It is explained in detail.
The design of most critical of the present invention is：The present invention is according to the characteristics of oral environment and mouth disease Main Pathogenic Bacteria is molten
Courageous and upright streptococcic biochemical character, by narrow leaved tea tree essential oil, green tea Aqueous extracts, water extract of flos lonicerae, citric acid, natural bee
Honey, xylitol and menthol are in suitable ratio compatibility, to be mixed and made into formula safety and can effectively inhibit hemolytic streptococcus
Gargle.
The present invention provides a kind of gargle, is mixed including following raw material：Narrow leaved tea tree essential oil 0.008~
0.03 part, 1~2 part of green tea Aqueous extracts, 0.008~0.02 part of water extract of flos lonicerae, 0.8~1.2 part of citric acid, natural honey
1.2~1.8 parts, 1.4~1.8 parts of xylitol, 0.008~0.02 part of menthol, 1 part of 1,3-BDO and purified water 92.13~
94.576 parts.
The pharmacological action of the present invention is as follows：
Citric acid is produced by adding in milk of lime in fruit juice-extracting process with forming the method that calcium citrate precipitates, can temperature
The lipolysis that oral cavity wall is extra, conceals germ will be deposited in ground；Natural honey has effects that anti-inflammatory analgetic, right
Canker sore, bleeding gums swelling have good action, oral cavity sense of discomfort of releiving；Menthol is carried by the leaf and stem of peppermint
It takes, there is refrigerant tasty and refreshing；Xylitol is a kind of natural, health sweetener；Water extract of flos lonicerae contains chlorogenic acid, green tea
Aqueous extracts contain more tea polyphenols, can be by interfering disease with above-mentioned various composition compatibility by water extract of flos lonicerae and green tea Aqueous extracts
The metabolism of bacterium to press down bactericidal, and then enhance to Escherichia coli, staphylococcus, hemolytic streptococcus inhibiting effect, and can tie up
Oral normal flora balance is held, does not generate drug resistance also, meanwhile, it will be in the liquid energy absorption food of gargling after above-mentioned each component compatibility
Peculiar smell, there is deodorization.
As can be seen from the above description, the beneficial effects of the present invention are：The present invention is according to the characteristics of oral environment and the disease of oral cavity
The biochemical character of sick Main Pathogenic Bacteria hemolytic streptococcus, by narrow leaved tea tree essential oil, green tea Aqueous extracts, water extract of flos lonicerae,
Citric acid, natural honey, xylitol and menthol are in suitable ratio compatibility, to be mixed and made into formula safety and can effectively inhibit
The gargle of hemolytic streptococcus, according to detection, gargle of the invention the bacteriostasis rate of hemolytic streptococcus is reached 99% with
On, to the bacteriostasis rates of Escherichia coli up to more than 91%.
Further, the parts by weight of the narrow leaved tea tree essential oil are 0.01 part.
Further, it is mixed by following raw material：0.008~0.03 part of narrow leaved tea tree essential oil, green tea water
1~2 part of extract, 0.008~0.02 part of water extract of flos lonicerae, 0.8~1.2 part of citric acid, 1.2~1.8 parts of natural honey, xylose
92.13~94.576 parts of 1.4~1.8 parts of alcohol, 0.008~0.02 part of menthol, 1 part of 1,3-BDO and purified water.
Further, it is mixed by following raw material：0.01 part of narrow leaved tea tree essential oil, green tea water carry 1.5 parts,
0.01 part of water extract of flos lonicerae, 1 part of citric acid, 1.5 parts of natural honey, 1.6 parts of xylitol, 0.01 part of menthol, 1,3- fourths two
93.37 parts of 1 part of alcohol and purified water.
The present invention provides a kind of preparation method of gargle, includes the following steps：
Step 1：By the narrow leaved tea tree essential oil of 0.008~0.03 parts by weight and the menthol of 0.008~0.02 parts by weight
It is mixed with the 1,3-BDO of 1 parts by weight, obtains just mixed liquid；
Step 2：The citric acid of 0.8~1.2 parts by weight is added in into the purified water of 92.13~94.576 parts by weight, then
Sequentially added while stirring the xylitols of 1.4~1.8 parts by weight, 1~2 parts by weight it is green tea Aqueous extracts, 0.008~
Water extract of flos lonicerae, step 1 gained of 0.02 parts by weight just mix liquid and the natural honey of 1.2~1.8 parts by weight, obtain target production
Object.
As can be seen from the above description, the beneficial effects of the present invention are：The present invention is according to the characteristics of oral environment and the disease of oral cavity
The biochemical character of sick Main Pathogenic Bacteria hemolytic streptococcus, by narrow leaved tea tree essential oil, green tea Aqueous extracts, water extract of flos lonicerae,
Citric acid, natural honey, xylitol and menthol can effectively inhibit hemolytic hammer in suitable ratio compatibility to be mixed
The gargle of bacterium, according to detection, gargle of the invention reaches more than 99% to the bacteriostasis rate of hemolytic streptococcus, to large intestine bar
The bacteriostasis rate of bacterium is up to more than 91%；The gargle of the present invention, mildly, non-stimulated without irritating chemical substance, adult and youngster
Tong Jun is applicable in.
Further, the temperature of the purified water is 15~30 DEG C.
Seen from the above description, the temperature for controlling purified water is 15~30 DEG C, as cold to match, and avoids each raw material of high temperature
In effective component so that the antipathogenic composition in gargle is not destroyed.
Further, the active constituent 4- pine tars alcohol content of the narrow leaved tea tree essential oil be more than 47.00wt%, 1,8-
The content of cineole is less than 2.42%.
Seen from the above description, the active constituent 4- pine tars alcohol content of above-mentioned narrow leaved tea tree essential oil is high, restraining and sterilizing bacteria effect
Fruit more preferably, while meets the daily use chemicals standard of tea tree ethereal oil.
Further, the narrow leaved tea tree essential oil is to pass through supercritical CO2Abstraction technique is prepared.
Seen from the above description, using critical CO2The narrow leaved tea tree essential oil that abstraction technique is prepared, can effectively avoid
The residual of organic solvent in narrow leaved tea tree essential oil, the impurity content of obtained narrow leaved tea tree essential oil is low, so that containing gargling
Liquid uses safer.
Further, the preparation of the green tea Aqueous extracts includes the water progress that 15~19 times of green tea weight is added in into green tea
Until the index of refraction of extracting solution is 1.34~1.36, filter and remove residue obtains green tea Aqueous extracts for extraction.
Further, the preparation of water extract of flos lonicerae is further included, the preparation of the water extract of flos lonicerae is included to honeysuckle
The middle water for adding in 6~8 times of honeysuckle weight carries out extraction until the index of refraction of extracting solution is 1.38~1.40, and filter and remove residue obtains
Water extract of flos lonicerae.
Embodiment 1
A kind of preparation method of gargle, includes the following steps：
(1) early-stage preparations：
The preparation of narrow leaved tea tree essential oil：Narrow leaved tea tree cauline leaf is placed in 70% ethyl alcohol and is infiltrated overnight, mutual leaf white thousand
The mass ratio of layer cauline leaf and ethyl alcohol is 1: 3, and microwave radiation, the microwave spoke are carried out to the narrow leaved tea tree cauline leaf after infiltrating overnight
Radio frequency rate is set as 2500MHz, and power is set as 5000W, and radiated time is set as 180s；To the narrow leaved tea tree sample after microwave treatment
Using supercritical CO2Extraction, fluid extraction temperature are set as 35 DEG C, CO2Fluid flow is 750L/h, extraction time 4h, is obtained mutually
Leaf Melaleuca oil crude extract；To supercritical CO2The narrow leaved tea tree essential oil being obtained by extraction carries out level-one distillation, and temperature is set as
75 DEG C, pressure is set as 6700Pa, detaches the alkane light component impurity that fragrance is influenced in narrow leaved tea tree essential oil, while ensure to lose
Less 4- terpinols；Secondary distillation is carried out to the residue of level-one distillation, temperature is set as 110 DEG C, and pressure is set as 10Pa, so as to
Detaching influences the heavy constituent substance of color and luster in narrow leaved tea tree essential oil, while ensures the yield of narrow leaved tea tree essential oil final product；
The content of 4- terebinths and the content of 1,8- cineole in narrow leaved tea tree essential oil final product are detected using GC/MS, is lived
Property ingredient 4- pine tars alcohol contents be 47.52wt%, the content of 1,8- cineole is 2.41%；
The preparation of green tea Aqueous extracts：It adds in the water of 17 times of green tea weight to extract to the index of refraction of extracting solution into green tea and is
1.35, filter and remove residue obtains green tea Aqueous extracts；
The preparation of water extract of flos lonicerae：It adds in the water of 8 times of honeysuckle weight and is extracted to the folding of extracting solution into honeysuckle
Light rate is 1.39, and filter and remove residue obtains water extract of flos lonicerae；
(2) it will mix, obtain in the narrow leaved tea tree essential oil of 0.008g and the menthol of 0.008g and the 1,3-BDO of 1g
Just mixed liquid；
(3) to citric acid of the temperature of 92.13g to add in 0.8g in 25 DEG C of purified waters, then successively while stirring
Xylitol, the green tea Aqueous extracts of 1g, the water extract of flos lonicerae of 0.008g, step 1 gained for adding in 1.4g just mix liquid and 1.2g
Natural honey, obtain target product.
Embodiment 2
The embodiment other with embodiment 1, the difference lies in：
It will mix, obtain just mixed in the narrow leaved tea tree essential oil of 0.03g and the menthol of 0.02g and the 1,3-BDO of 1g
Liquid；
It is that the citric acid of 1.2g is added in 25 DEG C of purified waters to the temperature of 94.576g, then successivelys while stirring and add
Xylitol, the green tea Aqueous extracts of 2g, the water extract of flos lonicerae of 0.02g, step 1 gained for entering 1.8g just mix liquid and the day of 1.8g
Right honey, obtains target product.
Embodiment 3
The embodiment other with embodiment 1, the difference lies in：
It will mix, obtain just mixed in the narrow leaved tea tree essential oil of 0.01g and the menthol of 0.01g and the 1,3-BDO of 1g
Liquid；
It is that the citric acid of 0.8~1.2g is added in 25 DEG C of purified waters to the temperature of 93.37g, then accordings to while stirring
It is secondary add in the xylitol of 1.6g, the green tea Aqueous extracts of 1.5g, the water extract of flos lonicerae of 0.01g, obtained by step 1 just mixed liquid and
The natural honey of 1.5g, obtains target product.
Embodiment 4
Antibacterial bacteriostatic effect test is carried out to 1~embodiment of embodiment 3,
Evaluation method is：The 7.3 antibacterial type daily use chemicals of evaluation method of QB/T 2738-2012 daily chemical products antibacterial bacteriostatic effects
The fungistatic effect method of inspection (suspension quantitative method) of product；
Testing strain is：Escherichia coli 8099, hemolytic streptococcus 32210；
Test result such as table 1：
1 test result of table
Conclusion such as table 2
2 conclusion of table
In conclusion gargle provided by the invention and preparation method thereof, the present invention is according to the characteristics of oral environment and mouth
The biochemical character of chamber disease Main Pathogenic Bacteria hemolytic streptococcus, narrow leaved tea tree essential oil, green tea Aqueous extracts, honeysuckle flower water are carried
Liquid, citric acid, natural honey, xylitol and menthol can effectively inhibit hemolytic in suitable ratio compatibility to be mixed
Streptococcic gargle, according to detection, gargle of the invention reaches more than 99% to the bacteriostasis rate of hemolytic streptococcus, to big
The bacteriostasis rate of enterobacteria is up to more than 91%；The gargle of the present invention, mildly, non-stimulated without irritating chemical substance, adult
It is applicable in children；The preparation method of the present invention, step is simple, is suitble to industrialized production.
The foregoing is merely the embodiment of the present invention, are not intended to limit the scope of the invention, every to utilize this hair
The equivalent structure or equivalent flow shift that bright description is made directly or indirectly is used in other relevant technology necks
Domain is included within the scope of the present invention.
Claims (10)
1. a kind of gargle, which is characterized in that mixed including following raw material：Narrow leaved tea tree essential oil 0.008~
0.03 part, 1~2 part of green tea Aqueous extracts, 0.008~0.02 part of water extract of flos lonicerae, 0.8~1.2 part of citric acid, natural honey
1.2~1.8 parts, 1.4~1.8 parts of xylitol, 0.008~0.02 part of menthol, 1 part of 1,3-BDO and purified water 92.13~
94.576 parts.
2. gargle according to claim 1, which is characterized in that the parts by weight of the narrow leaved tea tree essential oil are 0.01
Part.
3. gargle according to claim 1, which is characterized in that mixed by following raw material：Mutual leaf white thousand
0.008~0.03 part of essential oil of layer, 1~2 part of green tea Aqueous extracts, 0.008~0.02 part of water extract of flos lonicerae, citric acid 0.8~1.2
Part, 1.2~1.8 parts of natural honey, 1.4~1.8 parts of xylitol, 0.008~0.02 part of menthol, 1 part of 1,3-BDO and pure
Change 92.13~94.576 parts of water.
4. gargle according to claim 1, which is characterized in that mixed by following raw material：Mutual leaf white thousand
Layer 0.01 part of essential oil, green tea water carry 1.5 parts, 0.01 part of water extract of flos lonicerae, 1 part of citric acid, 1.5 parts of natural honey, xylitol
93.37 parts of 1.6 parts, 0.01 part of menthol, 1 part of 1,3-BDO and purified water.
5. a kind of preparation method of gargle, which is characterized in that include the following steps：
Step 1：By the narrow leaved tea tree essential oil of 0.008~0.03 parts by weight and the menthol and 1 weight of 0.008~0.02 parts by weight
It measures and is mixed in the 1,3-BDO of part, obtain just mixed liquid；
Step 2：The citric acid of 0.8~1.2 parts by weight is added in into the purified water of 92.13~94.576 parts by weight, then on one side
Stirring sequentially adds the xylitol of 1.4~1.8 parts by weight, green tea Aqueous extracts, 0.008~0.02 weight of 1~2 parts by weight on one side
The first mixed liquid of water extract of flos lonicerae, step 1 gained of part and the natural honey of 1.2~1.8 parts by weight are measured, obtains target product.
6. the preparation method of gargle according to claim 5, which is characterized in that the temperature of the purified water is 15~30
℃。
7. the preparation method of gargle according to claim 5, which is characterized in that the narrow leaved tea tree essential oil activity into
It is more than 47.00wt% to divide 4- pine tars alcohol content, and the content of 1,8- cineole is less than 2.42%.
8. the preparation method of gargle according to claim 5, which is characterized in that the narrow leaved tea tree essential oil is by super
Critical CO2Abstraction technique is prepared.
9. the preparation method of gargle according to claim 5, which is characterized in that further include the preparation of green tea Aqueous extracts, institute
The preparation for stating green tea Aqueous extracts carries out extraction until the folding of extracting solution including adding in the water of 15~19 times of green tea weight into green tea
Light rate is 1.34~1.36, and filter and remove residue obtains green tea Aqueous extracts.
10. the preparation method of gargle according to claim 5, which is characterized in that the preparation of water extract of flos lonicerae is further included,
The water that the preparation of the water extract of flos lonicerae includes adding in 6~8 times of honeysuckle weight into honeysuckle extract until extraction
The index of refraction of liquid is 1.38~1.40, and filter and remove residue obtains water extract of flos lonicerae.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004182649A (en) * | 2002-12-03 | 2004-07-02 | Fancl Corp | Composition for oral cavity |
| CN101991521A (en) * | 2010-11-03 | 2011-03-30 | 中国热带农业科学院农产品加工研究所 | Tea tree oil mouth wash and preparation method thereof |
| CN104414886A (en) * | 2013-08-21 | 2015-03-18 | 左华炜 | Mouthwash |
| CN107349171A (en) * | 2017-07-27 | 2017-11-17 | 安徽省银锂子生物科技发展有限公司 | A kind of effectively antibacterial, sterilization and the mouthwash for accelerating canker sore healing |
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| CN106010792A (en) * | 2016-06-27 | 2016-10-12 | 福建澳树佳生物科技有限公司 | Method for extracting melaleuca alternifolia and tea tree essence oil |
| CN106619284A (en) * | 2016-12-08 | 2017-05-10 | 西安中天生物医药有限公司 | Traditional Chinese medicine mouthwash for inhibiting bacteria in oral cavity and refreshing breath and preparation method thereof |
| CN107375171A (en) * | 2017-07-27 | 2017-11-24 | 陆方 | A kind of mouthwash |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004182649A (en) * | 2002-12-03 | 2004-07-02 | Fancl Corp | Composition for oral cavity |
| CN101991521A (en) * | 2010-11-03 | 2011-03-30 | 中国热带农业科学院农产品加工研究所 | Tea tree oil mouth wash and preparation method thereof |
| CN104414886A (en) * | 2013-08-21 | 2015-03-18 | 左华炜 | Mouthwash |
| CN107349171A (en) * | 2017-07-27 | 2017-11-17 | 安徽省银锂子生物科技发展有限公司 | A kind of effectively antibacterial, sterilization and the mouthwash for accelerating canker sore healing |
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