CN108159230A - A kind of paste for being used to treat respiratory tract infection - Google Patents

A kind of paste for being used to treat respiratory tract infection Download PDF

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Publication number
CN108159230A
CN108159230A CN201711480462.8A CN201711480462A CN108159230A CN 108159230 A CN108159230 A CN 108159230A CN 201711480462 A CN201711480462 A CN 201711480462A CN 108159230 A CN108159230 A CN 108159230A
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parts
paste
respiratory tract
tract infection
fruit powder
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谢剑兵
杨艳
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Panan Fusheng Food Science And Technology Co Ltd
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Panan Fusheng Food Science And Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention discloses a kind of for treating the paste of respiratory tract infection, it is made of the raw material that following weight matches：10 15 parts of radix pseudostellariae, 10 15 parts of cairo morningglory root or leaf, 10 15 parts of Radix Angelicae Sinensis, 10 15 parts of Poria cocos, 8 12 parts of Rhizoma Atractylodis Macrocephalae, mountain be cut 48 parts, 48 parts of rhizoma atractylodis, 10 15 parts of almond, 12 18 parts of Chinese yam, 7 12 parts of folium panacis japonici cum caule, 37 parts of Schisandra chinensis, 45 parts of loguat leaf, 37 parts of dried orange peel, 25 parts of rock sugar, 12 parts of honey, 35 parts of fruit powder, 0.2 0.4 parts of antistaling agent.It has the beneficial effect that：Compatibility is reasonable between each ingredient of paste of the present invention, mild in medicine property and, good mouthfeel, the infection of the upper respiratory tract, the number of acute bronchitis infection and the average time to break out every time and total severity extent can be reduced, it is notable to the therapeutic effect of respiratory tract infection, immunity of organisms can be enhanced, retentiveness is not good, easy to moisture absorption, long shelf-life.

Description

A kind of paste for being used to treat respiratory tract infection
Technical field
The present invention relates to a kind of paste, more particularly, to a kind of paste for being used to treat respiratory tract infection.
Background technology
Infantile respiratory tract infection repeatedly is a kind of common disease referred to as " Chinese medicinel ", and generally requiring long-time conditioning treatment can Achieve the effect that change pathological constitutional.Its cause of disease is complicated, and clinical characters are the upper lower respiratory tract infection of recurrent exerbation, the course of disease compared with Long, symptom is heavier, touching refractory, due to the physilogical characteristics of children's respiratory system, makes its respiratory inflammation easily to adjacent tissue Diffusion is such as cured not in time, and often further diffusion, invades entire respiratory system or even whole body, easily cause asthma, cardiac muscle The multiple complications such as inflammation, ephritis seriously affect the growth and development of children.Statistics shows that respiratory tract infection accounts for Pediatric Clinic The 80% of infant, wherein 30% is repeated respiratory infections, 0-6 Sui children's Chinese medicinel incidence is 9-13%, and constantly rising In, so actively anti-disease of effecting a permanent cure is of great significance, and increasingly cause the attention of medical worker.Cause infant's respiration at present The viral species of road infection are various, and variability is big, and body immunity again cannot be lasting, therefore doctor trained in Western medicine not yet finds special efficacy in the treatment Pharmaccine, also lack effective therapy, in this case, give full play to traditional Chinese medical science improvement, righting constitution, righting are dispelled Evil advantage, actively intervenes this disease.Therefore, on the problem of rational therapy childrens respiratory tract infection, how use is held Medicine opportunity selects appropriate drug, and how to effectively control symptoms, shorten the infant course of disease, are always that numerous medical personals face Major issue.
Paste is one of five great tradition dosage forms of Chinese medicine, have external application and it is for oral administration it is not, paste is with a long history, different times The preparation method of paste has their own characteristics each, with the development of the society, modern paste refers to that there is abundant land bed skilled clinician to distinguish body Matter combines dialectical, the differentiation of disease formulation in principle, has the correction that gets rid of illness, adjusts and mend the simultaneous paste for applying effect.Paste is as a kind of special Preparation, the advantage for having traditional Chinese herbal decoction incomparable, without decoction, is suitable for the modern of fast pace life, paste has in addition Good mouthfeel, drug effect ease up, stablize, persistently, take the features such as easy to carry, economical and practical, be treatment children's recurrent respiratory tract Dosage form is infected, recently as raising of the people to healthy concern, health care consciousness, the innovation for idea of curing the disease, traditional Chinese medicine is prevented The disease effect of curing the disease increasingly is paid attention to, paste as one of time-honored traditional Chinese medicine dosage form, adjust mend and therapeutic value by More and more people pay attention to, and in the case where current " Chinese medicinel " patient is continuously increased, fully excavates the therapeutic effect of paste, have Great social and economic benefit.But still belong to rare with the research of paste prevention infantile respiratory tract infection repeatedly.
Invention content
The purpose of the present invention is to provide compatibility between a kind of each ingredient is reasonable, mild in medicine property and, good mouthfeel, to respiratory tract The therapeutic effect of infection is notable, can enhance immunity of organisms, and retentiveness is not good, easy to moisture absorption, and long shelf-life breathes for treating The paste of road infection.
The problem of present invention in above-mentioned technology for mentioning, the technical solution taken is：One kind is used to treat respiratory tract sense The paste of dye, it is made of the raw material that following weight matches：10-15 parts of radix pseudostellariae, 10-15 parts of cairo morningglory root or leaf, Radix Angelicae Sinensis 10-15 Part, 10-15 parts of Poria cocos, 8-12 parts of Rhizoma Atractylodis Macrocephalae, 4-8 parts of mountain quarrel, 4-8 parts of rhizoma atractylodis, 10-15 parts of almond, 12-18 parts of Chinese yam, folium panacis japonici cum caule 7-12 parts, 3-7 parts of Schisandra chinensis, 4-5 parts of loguat leaf, 3-7 parts of dried orange peel, 2-5 parts of rock sugar, 1-2 parts of honey, 3-5 parts of fruit powder, antistaling agent 0.2-0.4 parts.Compatibility is reasonable between each ingredient of the paste, can play the effect of mutual gain, mild in medicine property and, good mouthfeel, tool There are strengthening the spleen and replenishing qi, tonifying lung to consolidate the function of table, improve pulmonary system, so as to reduce the infection of the upper respiratory tract, acute bronchitis sense The number of dye and the average time to break out every time and total severity extent also have clear improvement, while have both antiviral, anti-thin Bacterium, cholagogic protect liver and the inflammation that inhibits, improve immunity of organisms and other effects at clearing heat and detoxicating, preventing phlegm from forming and stopping coughing, and respiratory tract infection is controlled Therapeutic effect is notable, can shorten infant infection time, the administration time and dosage of other antibacterials is reduced, so as to provide one The selection of the new clinical treatment infantile respiratory tract infection of kind.
Preferably, the ingredient and its parts by weight of fruit powder are：30-40 parts of pyrus nivalis, 10-20 parts of shaddock, 5-8 parts of cumquat, sieve 5-8 parts of Chinese fruit, 2-4 parts of hawthorn, 0.004-0.006 parts of 20-30 parts of honey, 1-3 parts of beta-cyclodextrin and malic acid.The fruit powder collection is each The nutritive value of kind of fruit and honey is integrated, and play complementary synergy to their own intrinsic medical value, have cough-relieving, Resolving sputum, moistening lung, preventing cold, regulation of physiological functions disorder and other effects, while fragrance pleasant have promoting qi circulation and removing obstruction in the collateral, promote the production of body fluid The effect to help digestion so that the taste good of paste, unique flavor are easy to be received by pediatric patient.
Further preferably, fruit powder preparation method is：It is 1 by solid-liquid ratio:0.6-1.0（g/mL）By formula ratio pyrus nivalis, shaddock, In cumquat, Siraitia grosvenorii, hawthorn plus water, using high-speed tissue mashing machine be crushed to particle uniformly, it is fine and smooth, then add in bee Honey, beta-cyclodextrin and malic acid adjust pH to neutrality, then under conditions of temperature is 30-40 DEG C, pressure is 40-60Mpa into Row homogenization, by the good mixture of homogeneous air mass flow be 600-800L/h, inlet amount 14-17mL/min, into wind-warm syndrome It is spray-dried under conditions of 75-85 DEG C of 180-190 DEG C of degree and leaving air temp to get fruit powder, the addition of malic acid can promote The combination of organic molecule in beta-cyclodextrin molecule and fruit makes the complex compound of its shape stable structure, obtains fruit powder preferable Thermal stability so that fruit powder nutritional ingredient and fragrance matter can be protected not to be destroyed during following process, while can made Fruit powder has preferable rehydration performance, can be uniformly mixed in infusion liquid, improves the palatability for stopping paste.
Preferably, antistaling agent is D- D-sorbites, further preferably, antistaling agent is contains 0.33-0.37%L- sorboses The D- D-sorbites of alcohol, the antistaling agent are combined by the polyhydroxy of itself with the moisture of paste, promote holding of the paste to moisture, The water activity of paste is reduced simultaneously so that paste can keep fresh and its taste, prevent paste from dehydration occurring in storage life And the crystallizations such as sugar are precipitated, moreover it is possible to keep sweet tea, acid, the coordination of bitterness intensity and balance, enhance paste flavor, improve the sense of paste Official's mass, and the reasonable amount of L- D-sorbites can enhance the binding force of hydroxyl and moisture, can extend the storage life of paste, and L- D-sorbite can make in paste preserve during it is not easy to moisture absorption, paste relative density and original flavor can be kept.
A kind of preparation method of paste for treating respiratory tract infection is：Take formula ratio radix pseudostellariae, cairo morningglory root or leaf, Radix Angelicae Sinensis, Poria cocos, Rhizoma Atractylodis Macrocephalae, mountain quarrel, rhizoma atractylodis almond, Chinese yam, folium panacis japonici cum caule, Schisandra chinensis, loguat leaf, dried orange peel are 1 according to solid-liquid ratio:15-20（g/ mL）Thereto plus water, then slow boiling infusion 1-2h adds in rock sugar, honey, fruit powder and antistaling agent to infusion liquid and receives cream to relatively close The sticky paste for 1.32-1.45 is spent, is cooled down to get paste.The preparation method simple possible of the paste, it is at low cost, it is nontoxic Side effect.
A kind of instructions of taking of paste for treating respiratory tract infection is：0-6 Sui daily 4-6g, 6-8 Sui it is daily Take 8-12g, 9-14 Sui daily 15-20g is poured with warm water, stirred evenly and take, 2-3 times daily, 2 months are one The course for the treatment of avoids eating raw turnip, tealeaves, crab, raw food, pungent, fishes and shrimps stimulating food etc. during medication.Above-mentioned paste can be antiviral, anti-after taking Bacterium, cholagogic protect liver and the inflammation that inhibits, improve immunity of organisms etc. at clearing heat and detoxicating, preventing phlegm from forming and stopping coughing, can effectively less respiratory tract sense The number of dye and the average time to break out every time and total severity extent, it is notable to the therapeutic effect of respiratory tract infection, simultaneously The administration time and dosage of other antibacterials can be reduced.
Compared with prior art, the advantage of the invention is that：1）Compatibility is reasonable between each ingredient of paste of the present invention, can play The effect of mutual gain, mild in medicine property and, good mouthfeel has the function of that table is consolidated in strengthening the spleen and replenishing qi, tonifying lung, improves pulmonary system, together When have both antiviral, antibacterium, cholagogic protect liver and inhibit inflammation, clearing heat and detoxicating, preventing phlegm from forming and stopping coughing, improve the work(such as immunity of organisms Effect；2）The paste has preferable thermal stability and rehydration with fruit powder so that can retain the nutritional ingredient of fruit powder in paste And fragrance matter, improve the palatability for stopping paste；3）The paste antistaling agent can promote holding of the paste to moisture, and be not easy to inhale It is wet so that paste can keep fresh and its taste and relative density, improve the aesthetic quality of paste, extend the storage life of paste； 4）The paste take after can the number of effectively less respiratory tract infection and the average time to break out every time and total severity extent, It is notable to the therapeutic effect of respiratory tract infection, while the administration time and dosage of other antibacterials can be reduced.
Specific embodiment
The present invention program is described further below by embodiment：
Embodiment 1：
A kind of paste for being used to treat respiratory tract infection, it is made of the raw material that following weight matches：15 parts of radix pseudostellariae, five pawls 10 parts of dragon, 15 parts of Radix Angelicae Sinensis, 10 parts of Poria cocos, 12 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of mountain quarrel, 8 parts of rhizoma atractylodis, 10 parts of almond, 18 parts of Chinese yam, folium panacis japonici cum caule 7 Part, 7 parts of Schisandra chinensis, 4 parts of loguat leaf, 7 parts of dried orange peel, 2 parts of rock sugar, 2 parts of honey, 3 parts of fruit powder, 0.4 part of antistaling agent.The paste respectively into / compatibility is reasonable, can play the effect of mutual gain, mild in medicine property and, there is good mouthfeel strengthening the spleen and replenishing qi, tonifying lung to consolidate table Function improves pulmonary system, so as to reduce the infection of the upper respiratory tract, the number of acute bronchitis infection and breaking-out every time Average time and total severity extent also have clear improvement, while have both antiviral, antibacterium, cholagogic protect liver and inhibit scorching Disease, clearing heat and detoxicating, preventing phlegm from forming and stopping coughing improve immunity of organisms and other effects, notable to the therapeutic effect of respiratory tract infection, can shorten trouble Youngster's infection time reduces the administration time and dosage of other antibacterials, small so as to provide a kind of new clinical treatment The selection of youngster's respiratory tract infection.
The ingredient and its parts by weight of above-mentioned fruit powder be：30 parts of pyrus nivalis, 20 parts of shaddock, 5 parts of cumquat, 8 parts of Siraitia grosvenorii, hawthorn 2 Part, 0.006 part of 30 parts of honey, 1 part of beta-cyclodextrin and malic acid.The nutritive value of the various fruit of fruit powder collection and honey is one Body, and complementary synergy is played to their own intrinsic medical value, there is cough-relieving, resolving sputum, moistening lung, preventing cold, adjust life Dysfunction and other effects, while fragrance pleasant are managed, there is promoting qi circulation and removing obstruction in the collateral, promoting the production of body fluid helps digestion so that the mouthfeel of paste Preferably, unique flavor is easy to be received by pediatric patient.
Above-mentioned fruit powder preparation method is：It is 1 by solid-liquid ratio:1.0（g/mL）By formula ratio pyrus nivalis, shaddock, cumquat, arhat In fruit, hawthorn plus water, using high-speed tissue mashing machine be crushed to particle uniformly, it is fine and smooth, then add in honey, beta-cyclodextrin And malic acid, pH is adjusted to neutrality, then homogenization is carried out under conditions of temperature is 30 DEG C, pressure is 60Mpa, by homogeneous Good mixture is 600L/h in air mass flow, inlet amount 17mL/min, the item of 85 DEG C of 180 DEG C of inlet air temperature and leaving air temp It is spray-dried under part to get fruit powder, the addition of malic acid can promote beta-cyclodextrin molecule and organic molecule in fruit With reference to making the complex compound of its shape stable structure, fruit powder made to obtain preferable thermal stability so that can during following process Fruit powder nutritional ingredient and fragrance matter is protected not to be destroyed, while can make fruit powder that there is preferable rehydration performance, can endured It is uniformly mixed in boil liquid, improves the palatability for stopping paste.
Above-mentioned antistaling agent is D- D-sorbites, and further preferably, antistaling agent is the D- sorbs containing 0.33%L- D-sorbites Sugar alcohol, the antistaling agent are combined by the polyhydroxy of itself with the moisture of paste, promote holding of the paste to moisture, while reduce cream The water activity of agent so that paste can keep fresh and its taste, prevent paste from the knots such as dehydration and sugar occurring in storage life Partial crystallization goes out, moreover it is possible to and it keeps sweet tea, acid, the coordination of bitterness intensity and balance, enhances paste flavor, the aesthetic quality for improving paste, and The reasonable amount of L- D-sorbites can enhance the binding force of hydroxyl and moisture, can extend the storage life of paste, and L- D-sorbites Can make in paste preserve during it is not easy to moisture absorption, paste relative density and original flavor can be kept.
A kind of preparation method of paste for treating respiratory tract infection is：Take formula ratio radix pseudostellariae, cairo morningglory root or leaf, Radix Angelicae Sinensis, Poria cocos, Rhizoma Atractylodis Macrocephalae, mountain quarrel, rhizoma atractylodis almond, Chinese yam, folium panacis japonici cum caule, Schisandra chinensis, loguat leaf, dried orange peel are 1 according to solid-liquid ratio:20（g/mL） Thereto plus then water, slow boiling infusion 1h are to infusion liquid addition rock sugar, honey, fruit powder and antistaling agent receipts cream to relative density 1.45 sticky paste, cools down to get paste.The preparation method simple possible of the paste, it is at low cost, it has no toxic side effect.
A kind of instructions of taking of paste for treating respiratory tract infection is：0-6 Sui daily 4g, 6-8 Sui often take daily With 8g, 9-14 Sui daily 15g is poured with warm water, is stirred evenly and take, 2 times a day, 2 months as a treatment course, medication periods Between avoid eating raw turnip, tealeaves, crab, raw food, pungent, fishes and shrimps stimulating food etc..Above-mentioned paste can antiviral, antibacterium, cholagogic shield after taking Liver and inhibit inflammation, clearing heat and detoxicating, preventing phlegm from forming and stopping coughing, improve immunity of organisms etc., can effectively less respiratory tract infection number with And the average time to break out every time and total severity extent, it is notable to the therapeutic effect of respiratory tract infection, while other can be reduced The administration time and dosage of antibacterials.
Embodiment 2：
A kind of paste for being used to treat respiratory tract infection, it is made of the raw material that following weight matches：10 parts of radix pseudostellariae, five pawls 15 parts of dragon, 10 parts of Radix Angelicae Sinensis, 15 parts of Poria cocos, 8 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of mountain quarrel, 4 parts of rhizoma atractylodis, 15 parts of almond, 12 parts of Chinese yam, folium panacis japonici cum caule 12 Part, 3 parts of Schisandra chinensis, 5 parts of loguat leaf, 3 parts of dried orange peel, 5 parts of rock sugar, 1 part of honey, 5 parts of fruit powder, 0.2 part of antistaling agent.Above-mentioned antistaling agent For the D- D-sorbites containing 0.37%L- D-sorbites.
The ingredient and its parts by weight of above-mentioned fruit powder be：40 parts of pyrus nivalis, 10 parts of shaddock, 8 parts of cumquat, 5 parts of Siraitia grosvenorii, hawthorn 4 Part, 0.004 part of 20 parts of honey, 3 parts of beta-cyclodextrin and malic acid.Fruit powder preparation method is：It is 1 by solid-liquid ratio:0.6（g/mL）It will In formula ratio pyrus nivalis, shaddock, cumquat, Siraitia grosvenorii, hawthorn plus water, using high-speed tissue mashing machine be crushed to particle uniformly, Then exquisiteness adds in honey, beta-cyclodextrin and malic acid, adjust pH to neutrality, then temperature be 40 DEG C, pressure 40Mpa Under conditions of carry out homogenization, by the good mixture of homogeneous air mass flow be 800L/h, inlet amount 14mL/min, air inlet It is spray-dried under conditions of 75 DEG C of 190 DEG C of temperature and leaving air temp to get fruit powder.
A kind of preparation method of paste for treating respiratory tract infection is：Take formula ratio radix pseudostellariae, cairo morningglory root or leaf, Radix Angelicae Sinensis, Poria cocos, Rhizoma Atractylodis Macrocephalae, mountain quarrel, rhizoma atractylodis almond, Chinese yam, folium panacis japonici cum caule, Schisandra chinensis, loguat leaf, dried orange peel are 1 according to solid-liquid ratio:15（g/mL） Thereto plus then water, slow boiling infusion 2h are to infusion liquid addition rock sugar, honey, fruit powder and antistaling agent receipts cream to relative density 1.32 sticky paste, cools down to get paste.
A kind of instructions of taking of paste for treating respiratory tract infection is：0-6 Sui daily 6g, 6-8 Sui often take daily With 12g, 9-14 Sui daily 20g is poured with warm water, is stirred evenly and take, 3 times a day, 2 months as a treatment course, medication Period avoids eating raw turnip, tealeaves, crab, raw food, pungent, fishes and shrimps stimulating food etc..
Embodiment 3：
A kind of paste for being used to treat respiratory tract infection, it is made of the raw material that following weight matches：12 parts of radix pseudostellariae, five pawls 12 parts of dragon, 12 parts of Radix Angelicae Sinensis, 12 parts of Poria cocos, 10 parts of Rhizoma Atractylodis Macrocephalae, 6 parts of mountain quarrel, 6 parts of rhizoma atractylodis, 12 parts of almond, 15 parts of Chinese yam, folium panacis japonici cum caule 10 Part, 5 parts of Schisandra chinensis, 5 parts of loguat leaf, 5 parts of dried orange peel, 4 parts of rock sugar, 1.5 parts of honey, 4 parts of fruit powder, 0.3 part of antistaling agent.It is above-mentioned fresh-keeping Agent is the D- D-sorbites containing 0.35%L- D-sorbites.
The ingredient and its parts by weight of above-mentioned fruit powder be：35 parts of pyrus nivalis, 15 parts of shaddock, 6 parts of cumquat, 6 parts of Siraitia grosvenorii, hawthorn 3 Part, 0.005 part of 25 parts of honey, 2 parts of beta-cyclodextrin and malic acid.Fruit powder preparation method is：It is 1 by solid-liquid ratio:0.8（g/mL）It will In formula ratio pyrus nivalis, shaddock, cumquat, Siraitia grosvenorii, hawthorn plus water, using high-speed tissue mashing machine be crushed to particle uniformly, Then exquisiteness adds in honey, beta-cyclodextrin and malic acid, adjust pH to neutrality, then temperature be 35 DEG C, pressure 50Mpa Under conditions of carry out homogenization, by the good mixture of homogeneous air mass flow be 700L/h, inlet amount 15mL/min, air inlet It is spray-dried under conditions of 80 DEG C of 185 DEG C of temperature and leaving air temp to get fruit powder.
A kind of preparation method of paste for treating respiratory tract infection is：Take formula ratio radix pseudostellariae, cairo morningglory root or leaf, Radix Angelicae Sinensis, Poria cocos, Rhizoma Atractylodis Macrocephalae, mountain quarrel, rhizoma atractylodis almond, Chinese yam, folium panacis japonici cum caule, Schisandra chinensis, loguat leaf, dried orange peel are 1 according to solid-liquid ratio:18（g/mL） Thereto plus then water, slow boiling infusion 1.5h add in rock sugar, honey, fruit powder and antistaling agent to infusion liquid and receive cream to relative density For 1.4 sticky paste, cool down to get paste.
A kind of instructions of taking of paste for treating respiratory tract infection is：0-6 Sui daily 5g, 6-8 Sui often take daily With 10g, 9-14 Sui daily 18g is poured with warm water, is stirred evenly and take, 3 times a day, 2 months as a treatment course, medication Period avoids eating raw turnip, tealeaves, crab, raw food, pungent, fishes and shrimps stimulating food etc..
Routine operation in the operating procedure of the present invention is well known to those skilled in the art, herein without repeating.
Technical scheme of the present invention is described in detail in embodiment described above, it should be understood that the above is only For specific embodiments of the present invention, it is not intended to restrict the invention, all any modifications made in the spirit of the present invention, Supplement or similar fashion replacement etc., should all be included in the protection scope of the present invention.

Claims (8)

1. a kind of paste for being used to treat respiratory tract infection, it is characterised in that：The raw material that the paste is matched by following weight It is made：10-15 parts of radix pseudostellariae, 10-15 parts of cairo morningglory root or leaf, 10-15 parts of Radix Angelicae Sinensis, 10-15 parts of Poria cocos, 8-12 parts of Rhizoma Atractylodis Macrocephalae, mountain quarrel 4-8 It is part, 4-8 parts of rhizoma atractylodis, 10-15 parts of almond, 12-18 parts of Chinese yam, 7-12 parts of folium panacis japonici cum caule, 3-7 parts of Schisandra chinensis, 4-5 parts of loguat leaf, old 3-7 parts of skin, 2-5 parts of rock sugar, 1-2 parts of honey, 3-5 parts of fruit powder, 0.2-0.4 parts of antistaling agent, the antistaling agent are D- D-sorbites.
2. a kind of paste for being used to treat respiratory tract infection according to claim 1, it is characterised in that：The fruit powder into Divide and its parts by weight are：30-40 parts of pyrus nivalis, 10-20 parts of shaddock, 5-8 parts of cumquat, 5-8 parts of Siraitia grosvenorii, 2-4 parts of hawthorn, honey 0.004-0.006 parts of 20-30 parts, 1-3 parts of beta-cyclodextrin and malic acid.
3. a kind of paste for being used to treat respiratory tract infection according to claim 1 or 2, it is characterised in that：The fruit powder Preparation method is：It is 1 by solid-liquid ratio:0.6-1.0（g/mL）Water will be added in formula ratio pyrus nivalis, shaddock, cumquat, Siraitia grosvenorii, hawthorn, It is broken, honey, beta-cyclodextrin and malic acid are then added in, adjusts pH to neutrality, homogeneous is spray-dried to get fruit powder.
4. a kind of paste for being used to treat respiratory tract infection according to claim 1, it is characterised in that：The antistaling agent is D- D-sorbites containing 0.33-0.37%L- D-sorbites.
5. a kind of paste for being used to treat respiratory tract infection according to claim 1-5, it is characterised in that：The paste Preparation method is：Take formula ratio radix pseudostellariae, cairo morningglory root or leaf, Radix Angelicae Sinensis, Poria cocos, Rhizoma Atractylodis Macrocephalae, mountain quarrel, rhizoma atractylodis almond, Chinese yam, folium panacis japonici cum caule, five Taste, loguat leaf, dried orange peel are 1 according to solid-liquid ratio:15-20（g/mL）Thereto plus water, slow boiling infusion 1-2h, then to infusion Liquid adds in rock sugar, honey, fruit powder and antistaling agent and receives cream, cools down to get paste.
6. a kind of preparation method of paste for being used to treat respiratory tract infection according to claim 5, it is characterised in that：Institute The relative density for stating paste is 1.32-1.45.
7. a kind of paste for being used to treat respiratory tract infection according to claim 1-6, it is characterised in that：The paste Instructions of taking is：0-6 Sui daily 4-6g, 6-8 Sui daily 8-12g, 9-14 Sui daily 15-20g, is rushed with warm water Enter, stir evenly and take, 2-3 times daily, 2 months as a treatment course.
8. a kind of instructions of taking of paste for being used to treat respiratory tract infection according to claim 7, it is characterised in that：Institute Raw turnip, tealeaves, crab, raw food, pungent, fishes and shrimps stimulating food etc. are avoided eating during stating medication.
CN201711480462.8A 2017-12-29 2017-12-29 A kind of paste for being used to treat respiratory tract infection Pending CN108159230A (en)

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CN102380061A (en) * 2011-07-19 2012-03-21 马琳 Chinese medicinal composition for eliminating and dissolving phlegm and relieving cough, as well as preparation method and application thereof
CN102871175A (en) * 2012-10-15 2013-01-16 山东好当家海洋发展股份有限公司 Nutritious drink for moistening lung and arresting cough and method for preparing same
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Application publication date: 20180615