CN108157663A - Poultry feed additive and corresponding feed for salmonella - Google Patents
Poultry feed additive and corresponding feed for salmonella Download PDFInfo
- Publication number
- CN108157663A CN108157663A CN201810045756.6A CN201810045756A CN108157663A CN 108157663 A CN108157663 A CN 108157663A CN 201810045756 A CN201810045756 A CN 201810045756A CN 108157663 A CN108157663 A CN 108157663A
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- salmonella
- poultry
- feed additive
- feed
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
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- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
The present invention relates to a kind of poultry feed additive for salmonella, wherein the additive includes Thymol, carvacrol, cinnamic acid, lactic acid, butyric acid, tristerin, silica.The poultry feed additive for salmonella in the invention and its corresponding feed are employed, blocks salmonella vertical transmission/horizontal transmission；It improves breeder rate of fertilization, hatching of breeding eggs rate, reduce seedling chicken death rate, reduce salmonella quantity in poultry product (poultry, birds, beasts and eggs).Synergy, it is multiple antibacterial；Promoting immunity, reconditioning are multiple, and prevention is laid equal stress on；Sustained release technique, all-digestive tract are effective.
Description
Technical field
Technical field more particularly to feed addictive, in particular to one kind the present invention relates to feed are directed to salmonella
Poultry feed additive and corresponding feed.
Background technology
Fowl salmonellosis refers to the acute or chronic of as caused by any one or more members in Salmonella birds
Disease mainly includes white diarrhea and avian typhoid etc..
Salmonella positive breeder flock laying rate lower than negative breeder flock 9.0~34.6%, fertility rate of hatching egg low 4~9%,
Low 10% or so (Zhang Dexian 2013) of chickling-surviving rate.Once breeder infects, it is young that salmonella can propagate infection by horizontal/vertical
Chicken, the incidence 20~40% of the white scour of chicken, the death rate is up to 50% (Hou Lili 2011).Zhang Zhi's text etc. (2011) report infection is husky
Door Salmonella hen produces hatching egg 75% and carries disease germs, and the harm of salmonella can amplification be (a set of for generations in vain step by step in poultry industrial chain
Plumage Breeder hens averagely provide 42 sets of parental broiler-type chickens, and a set of parent Dai Bai plumages Breeder hens averagely provide 104 commercial broilers).
Poultry product (meat, egg) is the important medium (meat 29%, egg 20%, FDA, 2014) of human infection salmonella.It is husky
Door Salmonella can pollute egg by ovary, fallopian tubal；The salmonella being colonized in enteron aisle pollutes chicken when trunk is processed.It is dirty
The poultry product (meat, egg) of dye causes human infection salmonella into food chain.Occur fever, diarrhea, vomiting and abdomen after infection
Symptoms, the severe patients such as pain can cause death.Laying hen salmonella positive rate (Wang Hongning, 2012) between 0~33%, freely
The positive rate of salmonella reaches 76.7% (Han Lei 2010), slaughterhouse and supermarket's broiler chicken product Salmonella in the freshly-slaughtered poultry yolk of market
Bacterium positive rate is respectively 45.1%, 47.6% (Liu Jie 2012).Food poisoning caused by counting salmonella according to FDA occupies food-borne
Disease is the first, and the U.S. in 2013 goes to a doctor for 1027561 person-times caused by salmonella infection, and 19336 person-times are hospitalized, and 378 people are dead,
Economic loss is up to 3,700,000 dollars (FDA, 2014).European Food Safety Authority represents that there are 90000 salmonellas in European Union every year
Disease, economic loss are up to 3,000,000,000 Euros (ESFA, 2014).Drug resistance is caused simultaneously using antibiotic prevention salmonella in production
The problem of with antibiotic residue.
Mostly by purifying, feeding antibiotic or prevent salmonella by immune means in production.Purification is prevention man
A kind of salmonella-polluted effective means of fowl (poultry product), but purification has the following problems.Purify 100,000 sets of livestock on hand of high cost
The economic loss of Parent stock farm is up to million yuan (Wang Hong peaceful etc., 2012).Salmonella " secondary pollution " problem.It is anti-
Raw element prevention, most hatcheries injection of antibiotics control white scour of chicken outburst when seedling chicken goes out shell, reduces the chick stage death rate,
But antibiotic can not thoroughly remove salmonella from body, can only slow down its propagation or toxin expelling, once antibiotic is deactivated, it is husky
Door Salmonella " can be broken out ", while abuse of antibiotics causes salmonella generally existing drug resistance in chicken house during poultry production again
Property.Immune salmonella vaccine includes two kinds of inactivated vaccine and Attenuate vaccine, Attenuate vaccine protective efficacy limitation, it is impossible to generate cross protection
Effect (just for of the same race or same serotype salmonella)；The immune effect of Attenuate vaccine is good compared with inactivated vaccine, but uses weak poison
It will be unable to purify chicken group by serology after seedling.In addition factors, the salmonellas such as cost (artificial, vaccine) is immunized to be immunized
Acceptance is not high.
Therefore, there are problems for salmonella prevention in the prior art：1) conventional method purification is of high cost and there are secondary dirts
The problem of dye；The problem of antibiotic prevention causes bacterial drug resistance and antibiotic residue；2) for the theory of Salmonella problem
Study more, but there is presently no molding product, there is an urgent need for green, the products of efficient noresidue in poultry production.
Invention content
The shortcomings that the purpose of the present invention is overcoming the above-mentioned prior art, provides a kind of needle of green, efficient noresidue
To the poultry feed additive of salmonella.
To achieve these goals, the poultry feed additive for salmonella of the invention is as follows：
The present invention provides a kind of poultry feed additive for salmonella, the additive includes thyme
Phenol, carvacrol, cinnamic acid, lactic acid, butyric acid, tristerin, silica.
Preferably, the additive includes the component of following mass ratio：
Preferably, the preparation process of the feed addictive includes step：
Tristerin is added in dissolving tank and is melted；
Thymol, carvacrol, cinnamic acid, lactic acid, butyric acid are weighed, and is uniformly mixed in mixer, it is mixed to form first
Close object；
First mixture is put into dissolving tank and is uniformly mixed with the tristerin melted, forms the second mixing
Object；
The second mixture is transferred in pressurized tank rapidly；
Pressure is adjusted, is adsorbed the essential oil atomisation in the second mixture and by silica, is mixed, cools down to get described
The poultry feed additive for salmonella.
Preferably, white microparticle preparation is made in the additive.
Preferably, the feed addictive is with slow releasing function and acts on entire gastral feed addictive.
The present invention also provides a kind of feed, the feed adds including the poultry feed for salmonella
Add agent.
The poultry feed additive for salmonella in the invention and its corresponding feed are employed, blocks sramana
Salmonella vertical transmission/horizontal transmission；It improves breeder rate of fertilization, hatching of breeding eggs rate, reduce seedling chicken death rate, reduce poultry product (fowl
Meat, birds, beasts and eggs) in salmonella quantity.Synergy, it is multiple antibacterial；Promoting immunity, reconditioning are multiple, and prevention is laid equal stress on；Sustained release technique, totally disappeared
It is effective to change road.
Description of the drawings
Fig. 1 is sustained release effect of the poultry feed additive for salmonella in simulation poultry gastric environment of the present invention
Fruit.
Fig. 2 is sustained release effect of the poultry feed additive for salmonella in simulation poultry intestinal tract environment of the present invention
Fruit.
Fig. 3 is the storage stability of the poultry feed additive for salmonella of the present invention.
Fig. 4 is the husky to S. pullonum, enteritis of the poultry feed additive for salmonella of the present invention
Door Salmonella and the minimal inhibitory concentration of salmonella typhimurium.
Fig. 5 is the husky to S. pullonum, enteritis of the poultry feed additive for salmonella of the present invention
Door Salmonella and salmonella typhimurium antibacterial circle diameter.
Specific embodiment
In order to more clearly describe the technology contents of the present invention, carried out with reference to specific embodiment further
Description.
The present invention provides a kind of poultry feed additive for salmonella, the additive includes thyme
Phenol, carvacrol, cinnamic acid, lactic acid, butyric acid, tristerin, silica.
Wherein, the additive includes the component of following mass ratio：
The preparation process of the feed addictive includes step：
Tristerin is added in dissolving tank and is melted；
Thymol, carvacrol, cinnamic acid, lactic acid, butyric acid are weighed, and is uniformly mixed in mixer, it is mixed to form first
Close object；
First mixture is put into dissolving tank and is uniformly mixed with the tristerin melted, forms the second mixing
Object；
The second mixture is transferred in pressurized tank rapidly；
Pressure is adjusted, is adsorbed the essential oil atomisation in the second mixture and by silica, is mixed, cools down to get described
The poultry feed additive for salmonella.
Wherein, white microparticle preparation is made in the additive.The feed addictive be with slow releasing function and
Act on entire gastral feed addictive.
The present invention also provides a kind of feed, the feed adds including the poultry feed for salmonella
Add agent.
The product of the present invention is further described by the following examples.
Embodiment 1：
The feed addictive of the present invention is prepared using the component of following mass ratio：
Carvacrol 18%, Thymol 8%, cinnamic acid 15%, lactic acid 10%, butyric acid 5%, tristerin 14%,
Silica 30%.
Tristerin is added in dissolving tank and is melted；It is according to formula weighing liquid charging stock and equal in dispensing ladle mixing
It is even；It will be uniformly mixed in premixing essential oil input dissolving tank with having melted tristerin；Mixture is transferred to pressure rapidly
In power tank；Pressure is adjusted, essential oil atomisation by silica is adsorbed, mixes, cool down to get the specific implementation of product of the present invention
Example.
Embodiment 2：
Release conditions of the product in poultry digestive tract environment is simulated in above-described embodiment 1：
As shown in Fig. 1~2, the product after the process is in simulation poultry alimentary canal different parts environment digestive juice
In show preferable slow release effect.
Release rate in gastric environment is simulated is about 20%, the release efficiency about 80% in intestinal environment is simulated, can
Achieve the effect that sustained release.
Embodiment 3：
Storage (heat) stability during 50 DEG C of storages of 1 product of above-described embodiment：
As shown in figure 3,50 DEG C of product of the present invention is stored 4 months, loss of effective components illustrates product of the present invention less than 5%
Storage (heat) has good stability.
Embodiment 4：
The using effect assessment of 1 product of above-described embodiment：
1) to the extracorporeal bacteria inhibitor test of salmonella
Fig. 4 and Fig. 5, which is divided into, shows product of the present invention to S. pullonum, Bacterium enteritidis and mouse typhus sramana
The minimal inhibitory concentration and antibacterial circle diameter of Salmonella.From Fig. 4 it can be seen that product of the present invention is antibacterial to the minimum of three plants of salmonellas
For concentration between 0.25~0.35, fungistatic effect is preferable；As can be seen from Figure 5 test in three plants of salmonellas to product of the present invention with
Colistin sulfate (antibiotic) is more sensitive, and the fungistatic effect of product of the present invention is better than colistin sulfate.
2) animal experiment one：
Influence of 1 product of above-described embodiment to broiler chicken salmonella infection
Experimental design：
Experiment is public young using 320 1d AA+ broiler chicken, and 3 processing groups are assigned at random according to the weight principle of indifference, respectively
For control group (attacking poison, Basic drawing), antibiotic group (attacking poison, Basic drawing+200g/t Enrofloxacins), it is net group husky vertical (attack poison,
Basic drawing+800g/t sand is stood only), every group of 4 repetitions each repeat 10 chickens.Poison every chicken of group is attacked during 14d and gavages 0.2mL5
× 107cfu/mL Bacterium enteritidis.Attack 2 after poison, 7,14d, i.e. 16,21 and 28d of chicken when, each processing dissects 8 respectively
Chicken (2/repeat) takes liver, spleen, cecal content to carry out salmonella counting, test period 28d, before being divided into (1~
14d), two stages of later stage (15~18d) count production performance (the average feeding of each stage and full period as unit of repetition
Amount, average daily gain, feedstuff-meat ratio, death and culling rate)
Result of the test：
Influences of the A to production performance
The result shows that 1~14d, each feed intake that handles is without significant difference (P ＞ 0.05), compared with the control group, antibiotic group
Average daily gain with product group of the present invention significantly improves (P ＜ 0.05), and feedstuff-meat ratio significantly reduces (P ＜ 0.05), present invention production
The product group death rate is less than antibiotic group and control group；15~28d, each feed intake that handles is without significant difference (P ＞ 0.05), with compareing
Group is compared, and the average daily gain of antibiotic group and product group of the present invention significantly improves (P ＜ 0.05), feedstuff-meat ratio significantly (P ＜
0.05), the product group death rate of the present invention is less than antibiotic group and control group；1~28d respectively handles feed intake, feedstuff-meat ratio without notable
Difference (P ＞ 0.05), compared with the control group, the average daily gain of product group and antibiotic group of the present invention significantly improves (P ＜
0.05), the product group death rate of the present invention is less than antibiotic group and control group.
Influences of the B to salmonella quantity
Salmonella 2d is infected, compared with the control group, antibiotic group and product group of the present invention can reduce sand in liver
The quantity (P ＜ 0.05) of door Salmonella, and on the quantity of salmonella in spleen and cecal content without influence (P ＞ 0.05).Sense
Salmonella 7d is contaminated, antibiotic group and product group of the present invention can reduce number of the salmonella in spleen and cecal content
It measures (P ＜ 0.05), and on the quantity of salmonella in liver without influence (P ＞ 0.05).14d after infection salmonella, antibiosis
Plain group and product group of the present invention can reduce quantity (P ＜ 0.05) of the salmonella in cecal content, but to liver and spleen
The quantity of dirty middle salmonella is without influence (P ＞ 0.05).
3) animal experiment two：
Influence of 1 product of above-described embodiment to breeder production performance
Experimental design
Experiment is divided into three phases：First stage investigates 500g/t products of the present invention in diet and green foot fiber crops Breeder hens is produced
The influence of performance.Second stage investigates in diet chicken group's rate of fertilization and hatching rate after addition 500g/t product 30d of the present invention
Situation.Three phases are investigated in diet hatches 7 age in days survival rates before chick after addition 500g/t product 30d of the present invention.
Certain chicken house of test site Xinzheng of Henan.First stage experiment uses 26wk blueness foot fiber crops Breeder hens 5500 altogether,
Control group 2800；Test group is 2700；Control group fed Basic drawing (kind chicken house autogamy material)；It raises on test group feeding basis
Grain+500g/t products of the present invention；Testing full period free choice feeding, (feed intake 140g or so, is estimated by rule of thumb, is not united accurately
Meter).
Experiment second stage takes 264 pieces of (the processing groups 131 of qualified kind of Adult cockerel for feeding 30 days latter two groups of product of the present invention
Piece, 131 pieces of product group of the present invention), be put in 264 types (honest hatch machine factory) hatch machine, two processing hatching eggs separated during 19d
The rate of fertilization of two processing groups, hatching rate are investigated in hatching.
It tests the chick that three phases hatch each group to raise respectively in corresponding breeding cage, drink is freely eaten
Water, diet purchase reduce by 0.5 DEG C daily later in Henan commodity material factory, first day 33 DEG C of temperature.Daily observation chick state
And record death toll.
Result of the test
Influence of the A products of the present invention to breeder production performance
Production performance
Product of the present invention is added in diet as can be seen from the table can improve Yellow-feather broiler breeder laying rate, reduce dead
Rate.
Hatching criteria
Product of the present invention is added in diet as can be seen from the table can improve Yellow-feather broiler breeder rate of fertilization, hatching rate.
Influence of the B products of the present invention to the chick 7d death rates
Added in diet as can be seen from the table product of the present invention can Yellow-feather broiler breeder seedling chicken quality, in reduction seedling chicken 7d
The death rate.
The poultry feed additive for salmonella in the present invention and its corresponding feed are employed, is planted in product
Object extract has the antibacterial double effects with improving immunity；Butyric acid has preferable bacteriostasis, while butyric acid is on intestines
The good energy source of chrotoplast has the function of to repair intestinal mucosa；Lactic acid dissociation constant is relatively low, can be dissociated in small enteral
Certain H+ provides relatively low PH environment, inhibits harmful bacteria proliferation, while can increase the substances such as plant extracts to sand
The function and effect of door Salmonella；With slow release effect can be multilevel, comprehensive inhibit poultry alimentary canal in salmonella increasing
It grows.
The poultry feed additive for salmonella in the invention and its corresponding feed are employed, blocks sramana
Salmonella vertical transmission/horizontal transmission；It improves breeder rate of fertilization, hatching of breeding eggs rate, reduce seedling chicken death rate, reduce poultry product (fowl
Meat, birds, beasts and eggs) in salmonella quantity.Synergy, it is multiple antibacterial；Promoting immunity, reconditioning are multiple, and prevention is laid equal stress on；Sustained release technique, totally disappeared
It is effective to change road.
In this description, the present invention is described with reference to its specific embodiment.But it is clear that it can still make
Various modifications and alterations are without departing from the spirit and scope of the invention.Therefore, the description and the appended drawings should be considered as illustrative
And not restrictive.
Claims (6)
1. a kind of poultry feed additive for salmonella, which is characterized in that the additive include Thymol,
Carvacrol, cinnamic acid, lactic acid, butyric acid, tristerin, silica.
2. the poultry feed additive according to claim 1 for salmonella, which is characterized in that the addition
Agent includes the component of following mass ratio：
3. the poultry feed additive according to claim 1 or 2 for salmonella, which is characterized in that described
The preparation process of feed addictive includes step：
Tristerin is added in dissolving tank and is melted；
Thymol, carvacrol, cinnamic acid, lactic acid, butyric acid are weighed, and is uniformly mixed in mixer, forms the first mixture；
First mixture is put into dissolving tank and is uniformly mixed with the tristerin melted, forms the second mixture；
The second mixture is transferred in pressurized tank rapidly；
Pressure is adjusted, is adsorbed the essential oil atomisation in the second mixture and by silica, is mixed, cools down to get the needle
To the poultry feed additive of salmonella.
4. the poultry feed additive according to claim 1 or 2 for salmonella, which is characterized in that described
White microparticle preparation is made in additive.
5. the poultry feed additive according to claim 1 or 2 for salmonella, which is characterized in that described
Feed addictive is with slow releasing function and acts on entire gastral feed addictive.
6. a kind of feed, which is characterized in that the feed includes any one of Claims 1-4 for Salmonella
The poultry feed additive of bacterium.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810045756.6A CN108157663A (en) | 2018-01-17 | 2018-01-17 | Poultry feed additive and corresponding feed for salmonella |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810045756.6A CN108157663A (en) | 2018-01-17 | 2018-01-17 | Poultry feed additive and corresponding feed for salmonella |
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| CN108157663A true CN108157663A (en) | 2018-06-15 |
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| CN201810045756.6A Pending CN108157663A (en) | 2018-01-17 | 2018-01-17 | Poultry feed additive and corresponding feed for salmonella |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109601750A (en) * | 2018-11-29 | 2019-04-12 | 上海美农生物科技股份有限公司 | The green feed additive and preparation method thereof for preventing fowl necrotic enteritis |
| CN112931720A (en) * | 2021-03-04 | 2021-06-11 | 安佑生物科技集团股份有限公司 | Feed additive for improving salpingitis of laying fowls, preparation method and application thereof |
| CN114680233A (en) * | 2020-12-29 | 2022-07-01 | 浏阳乐佰有机营养有限公司 | Application of cinnamaldehyde in preparing feed, feed additive, veterinary drug or water-drinking preparation for preventing or treating poultry adenoid myogastritis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109601750A (en) * | 2018-11-29 | 2019-04-12 | 上海美农生物科技股份有限公司 | The green feed additive and preparation method thereof for preventing fowl necrotic enteritis |
| CN114680233A (en) * | 2020-12-29 | 2022-07-01 | 浏阳乐佰有机营养有限公司 | Application of cinnamaldehyde in preparing feed, feed additive, veterinary drug or water-drinking preparation for preventing or treating poultry adenoid myogastritis |
| CN112931720A (en) * | 2021-03-04 | 2021-06-11 | 安佑生物科技集团股份有限公司 | Feed additive for improving salpingitis of laying fowls, preparation method and application thereof |
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