CN1686307A - Composition for preventing and treating poultry bacterial disease - Google Patents

Abstract

A composite medicine for preventing and treating the bacterial dseases of domestic fowls is prepared from rifampin, scutellaria root, liquorice root, VC, VD and VE. Its preparing process is also disclosed.

Description

Composition for preventing and treating poultry bacterial disease

(1) invention field:

The invention belongs to animal medicinal composition.

(2) technical background:

Bacillus pasteurii disease, salmonellosis, colibacillosis and staphylococcosis are the bacterial diseasees to poultry farming production hazardness maximum.Simultaneously, the generation of Resistant strain and drug residue have become a veterinary applications and the very thorny difficult problem of livestock and poultry breeding industry, have restricted clinical application kind and drug use effect.

Pasteurella multocida mainly causes fowl cholera.Various poultry comprise all susceptibles such as chicken, duck, goose and turkey.It is popular that the duck group often is, a monthly age sickness rate height.Chicken often be distribute, the laying hen sensitivity.Sick fowl and bacillicarrier are the sources of infection, and the apparatus of pollution, drinking-water, feedstuff and insecticide etc. can be propagated this disease.Through respiratory tract and alimentary infection.Stress promotes the generation of primary disease.Primary disease is popular the most extensive in chickling, and pilosity is born in the chickling that hatches soon.Grow up and plant the infection of chicken, often be confined to ovary, ovum and fallopian tube etc. and locate.

Salmonellosis, the Excreta of the sick chicken and the chicken that carries disease germs is the important source of infection, infects through digestive tract and respiratory tract, also can reach the next generation through egg by the hen that carries disease germs.Contain pathogenic bacteria in testis of ill cock and the seminal fluid, can infect by breeding; The couveuse that sick chicken manure just pollutes often is important Vector of infection.In addition, the indoor temperature of brooding is too high or too low, and hen house is crowded, the place humidity, and the environment filth, feedstuff and nutrient deficiency etc. all are predisposing factorss.

Escherichia coli can or infect ovary because of the fecal pollution eggshell, fallopian tube is invaded in the egg, and the young fowl that the egg that carries disease germs is hatched is inapparent infection, some stress effect under apparent infection takes place, and infect healthy young fowl in the horizontal transmission mode.Digestive tract, respiratory tract are common infection doors, and copulation also can cause infection, and unhygienic, supercool, the overheated or temperature difference of environment is big etc. can both promote the generation of primary disease.The easy infection of broiler, laying hen has certain resistance.

Staphylococcus aureus is very wide in distributed in nature, and all birdss all can infect, especially chicken and turkey.With the susceptible of broiler, the chicken of various ages in days all can infect in the chicken, but morbidity is maximum with the chicken of 20 ~ 40 ages in days, and the chicken morbidity of growing up is less.Wound is the main route of infection, but also can be by digestive tract and respiratory infectious, and the chickling infection of navel cord also is common approach.

For a long time, because the blindness of common antibiotics is used repeatedly in a large number clinically, cause the pathogen of above-mentioned bacillary principal disease Resistant strain all to occur, thereby cause among chicken group or the duck group bacterial disease constantly to take place and popular, medicine control effect is very unobvious, not only causes the waste of medicine, and because the delay of the course of disease, cause epidemic situation constantly to increase the weight of, cause irremediable loss.Calendar year 2001 " development of the compound new drug of rifampicin " is classified as the tackling of key scientific and technical problems major project by Shandong Province education department, through repetition test research, on the basis of development for many years, has carried out improvement and perfect again.We adopt the method for the combination of Chinese and Western medicine, have developed that a kind of poultry The main pathogenic fungi is extremely sensitive, wide spectrum, efficient, low residual, and are difficult for producing the novel active drug of Resistant strain.

(3) summary of the invention:

The practice of poultry farming production and veterinary clinic shows, is badly in need of at present that a kind of poultry The main pathogenic fungi is extremely sensitive, wide spectrum, efficient, low residual, and is difficult for producing the novel active drug of Resistant strain.The present invention carries out scientific composition according to Chinese and western medicine theory and laboratory and clinical treatment test effect, develop a kind of effective medicine at poultry encountered pathogenic bacteria and Resistant strain thereof, prevent and treat this disease fast and effectively, wide spectrum is low residual, reduce raiser's loss, ensure the poultry prod safe and sanitary, promote the stable development and the human health of poultry farming.

The present invention relates to two kinds of Chinese medicines such as a kind of Western medicine of rifampicin and Radix Scutellariae, Radix Glycyrrhizae etc., and vitamin C, D, E, said medicine and synergist mix after processing and preparing.Each composition proportion by weight is as follows:

Rifampicin 10 grams, the alcohol extract of Radix Scutellariae, each 5 gram of Radix Glycyrrhizae, each 500 milligrams of vitamin C, D, E.

Rifampicin is to be exclusively used in the treatment tuberculosis originally, is applied to other treatment of diseases in recent years gradually, but because this medicine very easily produces Resistant strain, so clinical use is very limited.This animal medicinal composition inventor is when the effective medicine of the pseudo-tuberculosis of research sheep in 1994, by improvement to this defective of rifampicin medicine, successfully solve it and easily produced the problem of Resistant strain, be developed into have has a broad antifungal spectrum, targeting and penetrance is strong, curative effect is high, the bacteriology cures soon, can promote inflammatory products to absorb and characteristics newtype drugs such as inflammation reparation, captured the international difficult problem that the pseudo-tuberculosis of sheep can not thoroughly be cured, bacteriology's cure rate reaches 100%.Calendar year 2001 " development of the compound new drug of rifampicin " is classified as the tackling of key scientific and technical problems major project by Shandong Province education department, through repetition test research, on the basis of development for many years, has carried out improvement and perfect again.Bore in 2002 since the great special project of country's " research of dairy industry key technology ", prove by the internal and external test that is used for the mammitis of cow The main pathogenic fungi, this medicine also has powerful killing action to mastitis The main pathogenic fungi and Resistant strain thereof, can fast, thoroughly kill in the various inflammation focuses that comprise galactapostema and intracellular pathogen.In addition, bacterial diseasees such as milk cattle metritis, cow hoof inflammation, pneumonia also had significant curative effect.Bacteriology's cure rate to bacillary mastitiss such as streptococcus, staphylococcus, escherichia coli, suppurative corynebacterium, bacillus pyocyaneus is 100%.National inventing patent has been declared and obtained to the research achievement.

In the recent period, we are in the process of implementing country's " food safety " major scientific and technological project, main cause a disease and suckle medicine bacterial strain and drug residue etc. at poultry have carried out great deal of experimental, former prescription is improved, succeeded in developing the new prescription of Chinese medicine and western medicine in conjunction with the main pathogenic bacterium of control poultry.

Result of the test shows that the about 30-60% of principal agent rifampicin discharges through bile, and 10-20% discharges through urine, and all the other are discharged from feces.Inflammatory lesions had very strong targeting and characteristic of concentration in addition.Stop medicine after 3 days, drug residue free in the meat.

(4) description of drawings:

Fig. 1: the poultry bacterial infections is prevented and treated compositions processing process figure

1 is Radix Scutellariae among Fig. 1, and 2 is Radix Glycyrrhizae; 3 is Radix Scutellariae, glycyrol extract; 4 is rifampicin; 5 is mixture; 6,7,8 is vitamin C, D, E; 9 is packed products.

(5) best mode for carrying out the invention:

The processing process of this animal medicinal composition

Radix Scutellariae, Radix Glycyrrhizae weigh → shred → the sub-boiling water immersion → filtration of soak with ethanol → sediment → disengaging → centrifugal → supernatant+excipient → vacuum freeze-drying thing+rifampicin powder → vitamin → be mixed → packing → quality inspection → warehouse-in.

Prepare by following each composition weight ratio:

Radix Scutellariae (1), each 5 gram of Radix Glycyrrhizae (2), chopping adds 150 milliliters of 70% ethanol, stirs 8 hours, and sediment adds and breaks away from 150 milliliters of sub-boiling water, stirs 12 hours; Get alcohol, the filtration of water soak, the centrifugal impurity of removing, supernatant add excipient final vacuum lyophilizing (3), add rifampicin powder 10 grams (4), fully mix homogeneously (5) adds respectively 500 milligrams in vitamin C, D, E powder (6,7,8) again, be mixed, packing promptly gets (9).

The using method of this animal medicinal composition: drinking-water: convert water for every and drink for 10 kilograms, logotype 3-5 days; Spice: every adds 5 kilograms in feedstuff, stirs logotype 3-5 days.

Claims (1)

1, a kind of poultry bacterial disease or colibacillosis, salmonellosis and Bacillus pasteurii disease are prevented and treated compositions, it is characterized in that being: rifampicin 10 grams by the various components in proportions of drug weight, the alcohol extract of Radix Scutellariae, each 5 gram of Radix Glycyrrhizae, each 500 milligrams of vitamin C, D, E.

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