CN108137596A - 经取代的1,2-二氢-3H-吡咯并[1,2-c]咪唑-3-酮抗菌化合物 - Google Patents

经取代的1,2-二氢-3H-吡咯并[1,2-c]咪唑-3-酮抗菌化合物 Download PDF

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Publication number
CN108137596A
CN108137596A CN201680049395.1A CN201680049395A CN108137596A CN 108137596 A CN108137596 A CN 108137596A CN 201680049395 A CN201680049395 A CN 201680049395A CN 108137596 A CN108137596 A CN 108137596A
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CN
China
Prior art keywords
methyl
bases
butyl
pyrrolo
hydroxy
Prior art date
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Pending
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CN201680049395.1A
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English (en)
Chinese (zh)
Inventor
安妮-凯瑟琳·布卢姆斯坦
盖尔·马蒂厄
罗伊克·雅各布
弗洛伦斯·马塞
阿泽利·米雷
菲利普·潘乔德
克莉丝汀·施密特
吉恩-卢克·施佩克林
吉恩-菲利普·苏瑞韦特
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Aidu West Pharmaceutical Co Ltd
Original Assignee
Aidu West Pharmaceutical Co Ltd
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Filing date
Publication date
Application filed by Aidu West Pharmaceutical Co Ltd filed Critical Aidu West Pharmaceutical Co Ltd
Publication of CN108137596A publication Critical patent/CN108137596A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201680049395.1A 2015-09-03 2016-09-02 经取代的1,2-二氢-3H-吡咯并[1,2-c]咪唑-3-酮抗菌化合物 Pending CN108137596A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2015070144 2015-09-03
EPPCT/EP2015/070144 2015-09-03
PCT/EP2016/070695 WO2017037221A1 (en) 2015-09-03 2016-09-02 Substituted 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one antibacterial compounds

Publications (1)

Publication Number Publication Date
CN108137596A true CN108137596A (zh) 2018-06-08

Family

ID=56852279

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680049395.1A Pending CN108137596A (zh) 2015-09-03 2016-09-02 经取代的1,2-二氢-3H-吡咯并[1,2-c]咪唑-3-酮抗菌化合物

Country Status (17)

Country Link
US (1) US10314823B2 (https=)
EP (1) EP3344630B1 (https=)
JP (1) JP2018526391A (https=)
KR (1) KR20180049017A (https=)
CN (1) CN108137596A (https=)
AR (1) AR105889A1 (https=)
AU (1) AU2016313794B2 (https=)
BR (1) BR112018004343A2 (https=)
CA (1) CA2994996A1 (https=)
CL (1) CL2018000533A1 (https=)
EA (1) EA201890626A1 (https=)
HK (1) HK1256614A1 (https=)
IL (1) IL257757A (https=)
MX (1) MX2018002644A (https=)
PH (1) PH12018500323A1 (https=)
TW (1) TW201714885A (https=)
WO (1) WO2017037221A1 (https=)

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AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
TW201840569A (zh) * 2017-03-01 2018-11-16 瑞士商愛杜西亞製藥有限公司 (2r)-n-羥基-4-(6-((1-(2-羥基乙基)氮雜環丁烷-3-基)丁-1,3-二炔-1-基)-3-氧基-1h-吡咯并[1,2-c]咪唑-2(3h)-基)-2-甲基-2-(甲磺醯基)丁醯胺之結晶形式
WO2018224455A1 (en) 2017-06-07 2018-12-13 Basf Se Substituted cyclopropyl derivatives
WO2019038362A1 (en) 2017-08-24 2019-02-28 Idorsia Pharmaceuticals Ltd ANTIBACTERIAL PYRROLOIMIDAZOLONES
WO2019086452A1 (en) 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Antibacterial heteroaromatic compounds
WO2019121143A1 (en) 2017-12-20 2019-06-27 Basf Se Substituted cyclopropyl derivatives
JP7156199B2 (ja) * 2018-08-09 2022-10-19 信越化学工業株式会社 レジスト材料及びパターン形成方法
WO2020243423A1 (en) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Tead inhibitors and uses thereof
KR20220030222A (ko) 2019-05-31 2022-03-10 이케나 온콜로지, 인코포레이티드 Tead 억제제 및 이의 용도
CA3157279A1 (en) * 2019-11-21 2021-05-27 Paul Richard Sebahar Trpv4 receptor ligands

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WO2011073845A1 (en) * 2009-12-16 2011-06-23 Pfizer Inc. N-linked hydroxamic acid derivatives useful as antibacterial agents
WO2015036964A1 (en) * 2013-09-13 2015-03-19 Actelion Pharmaceuticals Ltd Antibacterial 2h-indazole derivatives
WO2015132228A1 (en) * 2014-03-04 2015-09-11 Actelion Pharmaceuticals Ltd 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents

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UA80500C2 (en) 2003-10-17 2007-09-25 Basf Ag Fungicidal mixture and agent for controlling rice pathogens, containing triazolopyrimidine derivative and metalaxyl-m, method for controlling rice pathogens and sowing material
DE102008044132A1 (de) 2008-11-27 2010-06-02 BSH Bosch und Siemens Hausgeräte GmbH Kältegerät mit zweiseitig anschlagbarer Tür
WO2011045703A2 (en) 2009-10-13 2011-04-21 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
US8853213B2 (en) 2011-01-03 2014-10-07 Hanmi Pharm. Co., Ltd Bicyclic compound for modulating G protein-coupled receptors
MA34963B1 (fr) 2011-03-07 2014-03-01 Pfizer Derives de fluoro-pyridinone utiles en tant qu'agents antibacteriens
WO2012137094A1 (en) 2011-04-08 2012-10-11 Pfizer Inc. Isoxazole derivatives useful as antibacterial agents
CA2830866A1 (en) 2011-04-08 2012-10-11 Pfizer Inc. Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
WO2013170165A1 (en) 2012-05-10 2013-11-14 Achaogen, Inc. Antibacterial agents
BR112015010649A2 (pt) 2012-11-16 2017-07-11 Bristol Myers Squibb Co moduladores de gpr40 à base de pirrolidina
WO2014165075A1 (en) 2013-03-12 2014-10-09 Achaogen, Inc. Antibacterial agents
WO2015066413A1 (en) 2013-11-01 2015-05-07 Novartis Ag Oxazolidinone hydroxamic acid compounds for the treatment of bacterial infections
AU2014368619B2 (en) 2013-12-19 2018-11-22 Idorsia Pharmaceuticals Ltd Antibacterial 1H-indazole and 1H-indole derivatives
ES2687040T3 (es) 2014-05-16 2018-10-23 Idorsia Pharmaceuticals Ltd Derivados antibacterianos de quinazolin–4(3H)–ona
SG11201703992YA (en) 2014-11-19 2017-06-29 Actelion Pharmaceuticals Ltd Antibacterial benzothiazole derivatives
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
EA201890600A1 (ru) 2015-08-28 2018-09-28 Идорсиа Фармасьютиклз Лтд Антибактериальные аннелированные производные пирролидин-2-она
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JP2019501896A (ja) 2015-12-08 2019-01-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 抗菌化合物としての置換ベンザジノン
TW201741308A (zh) 2016-05-17 2017-12-01 愛杜西亞製藥有限公司 6-(丁-1,3-二炔-1-基)苯并[d]噻唑衍生物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011073845A1 (en) * 2009-12-16 2011-06-23 Pfizer Inc. N-linked hydroxamic acid derivatives useful as antibacterial agents
WO2015036964A1 (en) * 2013-09-13 2015-03-19 Actelion Pharmaceuticals Ltd Antibacterial 2h-indazole derivatives
WO2015132228A1 (en) * 2014-03-04 2015-09-11 Actelion Pharmaceuticals Ltd 1,2-dihydro-3h-pyrrolo[1,2-c]imidazol-3-one derivatives and their use as antibacterial agents

Also Published As

Publication number Publication date
KR20180049017A (ko) 2018-05-10
HK1256614A1 (zh) 2019-09-27
BR112018004343A2 (pt) 2018-09-25
AU2016313794B2 (en) 2020-06-04
EA201890626A1 (ru) 2018-09-28
TW201714885A (zh) 2017-05-01
EP3344630A1 (en) 2018-07-11
WO2017037221A1 (en) 2017-03-09
CL2018000533A1 (es) 2018-06-29
JP2018526391A (ja) 2018-09-13
US20180250273A1 (en) 2018-09-06
US10314823B2 (en) 2019-06-11
EP3344630B1 (en) 2020-12-09
CA2994996A1 (en) 2017-03-09
AU2016313794A1 (en) 2018-04-19
PH12018500323A1 (en) 2018-08-13
IL257757A (en) 2018-04-30
MX2018002644A (es) 2018-06-20
AR105889A1 (es) 2017-11-22

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Effective date of abandoning: 20210611