CN108137575A - 熊去氧胆酸与小檗碱或左旋肉碱的共轭化合物和其组合物及其方法 - Google Patents

熊去氧胆酸与小檗碱或左旋肉碱的共轭化合物和其组合物及其方法 Download PDF

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CN108137575A
CN108137575A CN201680032575.9A CN201680032575A CN108137575A CN 108137575 A CN108137575 A CN 108137575A CN 201680032575 A CN201680032575 A CN 201680032575A CN 108137575 A CN108137575 A CN 108137575A
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acid
derivative
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group derived
pharmaceutical composition
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刘利平
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Shenzhen Jun Shengtai Bioisystech Co Ltd
Shenzhen Hightide Biopharmaceutical Ltd
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Shenzhen Jun Shengtai Bioisystech Co Ltd
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
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CN201680032575.9A 2015-04-06 2016-04-05 熊去氧胆酸与小檗碱或左旋肉碱的共轭化合物和其组合物及其方法 Pending CN108137575A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562143734P 2015-04-06 2015-04-06
US62/143734 2015-04-06
PCT/CN2016/078414 WO2016161921A1 (en) 2015-04-06 2016-04-05 Conjugate compounds of ursodeoxycholic, berberine or l-carnitine, and compositions and methods thereof

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CN108137575A true CN108137575A (zh) 2018-06-08

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US (2) US20180050048A1 (enExample)
EP (1) EP3280712A4 (enExample)
JP (1) JP2018517666A (enExample)
CN (1) CN108137575A (enExample)
AU (1) AU2016245590A1 (enExample)
CA (1) CA2981754A1 (enExample)
IL (1) IL254831A0 (enExample)
SG (1) SG11201708030XA (enExample)
WO (1) WO2016161921A1 (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113045689A (zh) * 2021-03-24 2021-06-29 齐鲁工业大学 一种小檗碱-环糊精缀合物
CN114195851A (zh) * 2020-09-18 2022-03-18 成都贝诺科成生物科技有限公司 一种用于防治肝病的化合物及其药用组合物
CN114716498A (zh) * 2022-01-20 2022-07-08 成都贝诺科成生物科技有限公司 一种高稳定性的失碳熊去氧胆酸小檗碱盐晶型及其制备方法
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