CN108126232A - Hydrocolloid oil yarn and preparation method thereof - Google Patents
Hydrocolloid oil yarn and preparation method thereof Download PDFInfo
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- CN108126232A CN108126232A CN201711489779.8A CN201711489779A CN108126232A CN 108126232 A CN108126232 A CN 108126232A CN 201711489779 A CN201711489779 A CN 201711489779A CN 108126232 A CN108126232 A CN 108126232A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/34—Oils, fats, waxes or natural resins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
Abstract
The present invention relates to a kind of hydrocolloid oil yarns to include base material and hydrocolloid ingredient；The base material is reticulated polyester fiber；The hydrocolloid ingredient includes the raw material of following parts by weight：5 10 parts of 8 10 parts of thermoplastic elastomer (TPE), 16 30 parts of sodium carboxymethylcellulose, 15 parts of growth factor microballoon, 15 parts of chitosan, 100 200 parts of atoleine, 30 40 parts of vaseline and lanolin.The content of growth factor is 0.01wt% 0.03wt% in the growth factor microballoon.
Description
Technical field
The present invention relates to field of medical materials, more particularly to hydrocolloid oil yarn and preparation method thereof.
Background technology
Human skin can not only make one homoiostasis, while can also prevent the invasion of bacterium, microorganism.Work as skin
When skin injury, under conditions of homeostasis is broken, medical dressing can give human body as a kind of medical material that cures the wound
Certain necessary protection, reduces the extent of injury.Before skin recovery, good medical dressing temporary can play a part
Skin blocks the effect of function, and the healing for wound provides advantageous condition.
Existing dressing speed of wound healing is slow, plays the role of surface of a wound drainage, covering and filling mostly, and healing
Easy adhesion wound in the process, leads to bleeding, causes secondary injury, pain after patient's more change dressings.
Invention content
Based on this, it is necessary in view of the above-mentioned problems, providing a kind of hydrocolloid oil yarn and preparation method thereof.
It is an object of the present invention to provide a kind of hydrocolloid oil yarns.
Specific technical solution is as follows：
A kind of hydrocolloid oil yarn, including base material and hydrocolloid ingredient；
The base material is reticulated polyester fiber；
The hydrocolloid ingredient includes the raw material of following parts by weight：
8-10 parts of thermoplastic elastomer (TPE), sodium carboxymethylcellulose 16-30,1-5 parts of growth factor microballoon, 1-5 parts of chitosan,
5-10 parts of 100-200 parts of atoleine, 30-40 parts of vaseline and lanolin.
The content of growth factor is 0.01wt%-0.02wt% in the growth factor microballoon.
The weight ratio of the growth factor microballoon and chitosan is (1-2) in one of the embodiments,:1.
The weight ratio of the atoleine, vaseline and lanolin is (15-20) in one of the embodiments,：(4-
6)：1.
The growth factor microballoon includes following parts by weight raw material in one of the embodiments,：
0.01-0.02 parts of growth factor, lactic acid/50-100 parts of glycolic acid copolymers, 1-5 parts of seralbumin and poly- second two
400 0.05-0.1 parts of alcohol.
The preparation method of the growth factor microballoon includes the following steps in one of the embodiments,：
The growth factor, seralbumin and polyethylene glycol 400 are added in deionized water, obtains inner aqueous phase W1；In two
Lactic acid/glycolic acid copolymers are added in chloromethanes/acetone mixture, obtain oil phase O；Using polyvinyl alcohol water solution as outer aqueous phase
W2；
Add in the inner aqueous phase W1 in the oil phase O, ultrasound, obtains colostrum W1/O under ice bath；
It is added in outer aqueous phase W2 by the colostrum W1/O, is stirred under ice bath, obtain emulsion W1/O/W2；
The emulsion W1/O/W2, solvent flashing are added in sodium chloride solution, filtering obtains growth factor microballoon.
The growth factor is selected from the one or more of EGF, FGF, TGF, VEGF, PDGF in one of the embodiments,.
The thermoplastic elastomer (TPE) is selected from one kind or several of SBS, SIS, SEPS and SEBS in one of the embodiments,
Kind.
In one of the embodiments, the SEBS be selected from U.S. Kraton G1650, G1651 and G1652 one kind or
It is several.
The grain size of the growth factor microballoon is 1 μm -40 μm in one of the embodiments,；And/or
The particle aperture of the sodium carboxymethylcellulose is 20 μm -150 μm.
It is a further object to provide the preparation methods of above-mentioned hydrocolloid oil yarn.
Specific technical solution is：
A kind of preparation method of hydrocolloid oil yarn, includes the following steps：
Each raw material is weighed by above-mentioned parts by weight；
The thermoplastic elastomer (TPE), atoleine, vaseline and lanolin are softened into 20-40min, temperature 100-200
DEG C, obtain mixture；
In the mixture, the sodium carboxymethylcellulose and chitosan are added in, is mixed, temperature 100-120
DEG C, obtain fusant, vacuum defoamation；
The fusant after vacuum defoamation is coated on the base material, obtains base material net；
The growth factor microballoon is sprayed on the net in base material, obtains hydrocolloid oil yarn.
It the principle of the present invention and has the beneficial effect that：
Base material is reticulated polyester fiber, good permeability, and have certain mechanical strength, the substances such as coating thermoplastic elastomer (TPE)
Afterwards, on the one hand, make the soft easily curling of hydrocolloid oil yarn of the present invention and indeformable, have to being difficult to fixed wound and preferably comply with
Property；On the other hand, thermoplastic elastomer (TPE) forms gel in reticulated polyester fiber surface, and granulation tissue is not easy to grow to fiber mesh
In, and then it is not easy adhesion wound；Thermoplastic elastomer (TPE) has good compatibility with atoleine, vaseline and lanolin, and
Skin-tolerant can be improved；A small amount of sodium carboxymethylcellulose can keep certain humidity in wound surface, which avoids enough
Wound is dried, and CMC-Na causes stickum to become gel the absorption of diffusate so that can be painlessly after oily yarn use
It is removed from wound；Chitosan particle is added to, plays good antibacterial action, is effectively protected the healing of wound；Growth because
Sub- microballoon takes part in the whole process of wound healing and plays very important effect wherein, the addition of growth factor microballoon
The effect of improving hydrocolloid oil yarn wound healing effect.
Compared with existing scheme, the invention has the advantages that：
Above-mentioned hydrocolloid oil yarn, acts on wound surface, creates an existing humidity, and has antibacterial effect and can promote
The healing microenvironment of regeneration and restoration.Since the not viscous wound surface of its use and surrounding skin, more change dressings are painless
It is bitter, without bleeding, extraneous tissue will not be damaged.
Further, the ratio of atoleine, vaseline and lanolin is controlled, improves the imbibition of hydrocolloid oil yarn of the present invention
Amount and penetrability, on the more surface of a wound of sepage, can accelerate the healing of wound；Control the ratio of growth factor microballoon and chitosan
Example builds a more preferably repairing environment for wound, promotes wound healing and regeneration and restoration；
In addition, growth factor is not easy to preserve, growth factor microballoon is prepared as, its bin stability can be improved.
Specific embodiment
The hydrocolloid oil yarn of the present invention is described in further detail below in conjunction with specific embodiment.
SBS is Styrene-Butadiene-Styrene Block Copolymer；
SIS is styrene-isoprene-styrene block copolymer；
SEPS is styrene ethylene-propylene-styrene block copolymer；
SEBS is styrene-ethylene-butylene-styrene block copolymer
EGF (epidermal growth factor) growth factor includes epidermal growth factor；
FGF (fibroblast growth factor) fibroblast growth factor；
PDGF (platelet derived growth factor) platelet derived growth factor；
VEGF (human vascular endothelial growth factor) human vascular endothelial growth factor；
TGF (transforming growth factor) transforming growth factor.
The raw material used of the specific embodiment of the invention derives from commercially available.
Embodiment 1
The present embodiment provides a kind of hydrocolloid oil yarn, concrete scheme is：
A kind of hydrocolloid oil yarn, by base material and hydrocolloid into being grouped as；
The base material is reticulated polyester fiber,
The hydrocolloid ingredient is prepared from the following raw materials in parts by weight：
8 parts of G1651,30 parts of sodium carboxymethylcellulose, 1 part of growth factor microballoon, 1 part of chitosan, 100 parts of atoleine,
5 parts of 30 parts of vaseline and lanolin.
The preparation method of the hydrocolloid oil yarn of the present embodiment includes the following steps：
Each raw material is weighed by above-mentioned parts by weight；
By G1651, atoleine, vaseline and lanolin, soften in a kettle at a temperature of 200 DEG C 30 minutes,
Obtain mixture；
In the mixture, the sodium carboxymethylcellulose and chitosan, of the sodium carboxymethylcellulose are added in
Grain aperture is 75 μm.20min is mixed with the rotating speed of 100r/min, temperature is 100 DEG C, obtains fusant, vacuum defoamation；
The fusant after vacuum defoamation is coated on the reticulated polyester fiber, obtains base material net；
The concrete technology of coating is：The fusant is placed in the constant-temperature glue groove in double roller coating machine, the temperature in glue groove
Degree is maintained at 100 DEG C.Reticulated polyester fiber is uniformly covered with the applicator roll of one layer of fusant by first, and one layer of coating in advance is molten
Melt object；Remove fusant extra in mesh in reticulated polyester fiber using second applicator roll, obtain base material net.Wherein, it is double
The spacing of roller is 2mm, coating speed 4.5m/min.
Growth factor microballoon is quantitatively made an addition to by not yet cooling base material by spray mode online, cooling, overlay film, shearing
And packaging, obtain hydrocolloid oil yarn A.
The growth factor microballoon is prepared using W/O/W double emulsion solvents volatility process.Specific preparation method is as follows：
10 μ g of epidermal growth factor, 100 μ of seralbumin 1mg and polyethylene glycol 400 are added in 100 μ L deionized waters
L (density 1.110g/L) obtains inner aqueous phase W1；Lactic acid/glycolic acid copolymers are added in 4mL dichloromethane/acetone mixture
50mg obtains oil phase O；1.5mg polyvinyl alcohol is dissolved in 100mL water, obtains polyvinyl alcohol water solution, as outer aqueous phase W2；
Add in the inner aqueous phase W1 in the oil phase O, ultrasound, obtains colostrum W1/O under ice bath；
It is added in outer aqueous phase W2 by the colostrum W1/O, is stirred under ice bath, obtain emulsion W1/O/W2；
The emulsion W1/O/W2 is added in the sodium chloride deionized water solution of 400mL10%, volatile residue is stirred at room temperature
Organic solvent collects microballoon by miillpore filter, is washed with deionized, vacuum freeze drying, is placed in 4 DEG C of preservations, must grow
Factor microballoon.
The grain size of the growth factor microballoon is 10 μm.
Embodiment 2
The present embodiment provides a kind of hydrocolloid oil yarn, concrete scheme is：
A kind of hydrocolloid oil yarn, by base material and hydrocolloid into being grouped as；
The base material is reticulated polyester fiber,
The hydrocolloid ingredient is prepared from the following raw materials in parts by weight：
9 parts of G1651,25 parts of sodium carboxymethylcellulose, 3 parts of growth factor microballoon, 3 parts of chitosan, 130 parts of atoleine,
7 parts of 30 parts of vaseline and lanolin.
The preparation method of the hydrocolloid oil yarn of the present embodiment includes the following steps：
Each raw material is weighed by above-mentioned parts by weight；
By G1651, atoleine, vaseline and lanolin, soften in a kettle at a temperature of 200 DEG C 30 minutes,
Obtain mixture；
In the mixture, the sodium carboxymethylcellulose and chitosan, of the sodium carboxymethylcellulose are added in
Grain aperture is 75 μm.20min is mixed with the rotating speed of 100r/min, temperature is 100 DEG C, obtains fusant, vacuum defoamation；
The fusant after vacuum defoamation is coated on the reticulated polyester fiber, obtains base material net；
The concrete technology of coating is：The fusant is placed in the constant-temperature glue groove in double roller coating machine, the temperature in glue groove
Degree is maintained at 100 DEG C.Reticulated polyester fiber is uniformly covered with the applicator roll of one layer of fusant by first, is coated with one layer in advance
Fusant；Remove fusant extra in mesh in reticulated polyester fiber using second applicator roll, obtain base material net.Wherein,
The spacing of double roller is 2mm, coating speed 4.5m/min.
Growth factor microballoon is quantitatively made an addition to by not yet cooling base material by spray mode online, cooling, overlay film, shearing
And packaging, obtain hydrocolloid oil yarn B.
The growth factor microballoon is prepared using W/O/W double emulsion solvents volatility process.Specific preparation method is as follows：
10 μ g of epidermal growth factor, 70 μ L of seralbumin 2mg and polyethylene glycol 400 are added in 100 μ L deionized waters
(density 1.110g/L) obtains inner aqueous phase W1；Lactic acid/glycolic acid copolymers are added in 4mL dichloromethane/acetone mixture
60mg obtains oil phase O；1.5mg polyvinyl alcohol is dissolved in 100mL water, obtains polyvinyl alcohol water solution, as outer aqueous phase W2；
Add in the inner aqueous phase W1 in the oil phase O, ultrasound, obtains colostrum W1/O under ice bath；
It is added in outer aqueous phase W2 by the colostrum W1/O, is stirred under ice bath, obtain emulsion W1/O/W2；
The emulsion W1/O/W2 is added in the sodium chloride deionized water solution of 400mL10%, volatile residue is stirred at room temperature
Organic solvent collects microballoon by miillpore filter, is washed with deionized, vacuum freeze drying, is placed in 4 DEG C of preservations, must grow
Factor microballoon.
The grain size of the growth factor microballoon is 20 μm.
Embodiment 3
The present embodiment provides a kind of hydrocolloid oil yarn, concrete scheme is：
A kind of hydrocolloid oil yarn, by base material and hydrocolloid into being grouped as；
The base material is reticulated polyester fiber,
The hydrocolloid ingredient is prepared from the following raw materials in parts by weight：
10 parts of G1651,20 parts of sodium carboxymethylcellulose, 4 parts of growth factor microballoon, 4 parts of chitosan, atoleine 150
9 parts of part, 35 parts of vaseline and lanolin.
The preparation method of the hydrocolloid oil yarn of the present embodiment includes the following steps：
Each raw material is weighed by above-mentioned parts by weight；
By G1651, atoleine, vaseline and lanolin, soften in a kettle at a temperature of 200 DEG C 30 minutes,
Obtain mixture；
In the mixture, the sodium carboxymethylcellulose and chitosan, of the sodium carboxymethylcellulose are added in
Grain aperture is 75 μm.20min is mixed with the rotating speed of 100r/min, temperature is 100 DEG C, obtains fusant, vacuum defoamation；
The fusant after vacuum defoamation is coated on the reticulated polyester fiber, obtains base material net；
The concrete technology of coating is：The fusant is placed in the constant-temperature glue groove in double roller coating machine, the temperature in glue groove
Degree is maintained at 100 DEG C.Reticulated polyester fiber is uniformly covered with the applicator roll of one layer of fusant by first, is coated with one layer in advance
Fusant；Remove fusant extra in mesh in reticulated polyester fiber using second applicator roll, obtain base material net.Wherein,
The spacing of double roller is 2mm, coating speed 4.5m/min.
Growth factor microballoon is quantitatively made an addition to by not yet cooling base material by spray mode online, cooling, overlay film, shearing
And packaging, obtain hydrocolloid oil yarn C.
The growth factor microballoon is prepared using W/O/W double emulsion solvents volatility process.Specific preparation method is as follows：
20 μ g of epidermal growth factor, 60 μ L of seralbumin 3mg and polyethylene glycol 400 are added in 100 μ L deionized waters
(density 1.110g/L) obtains inner aqueous phase W1；Lactic acid/glycolic acid copolymers are added in 4mL dichloromethane/acetone mixture
80mg obtains oil phase O；1.5mg polyvinyl alcohol is dissolved in 100mL water, obtains polyvinyl alcohol water solution, as outer aqueous phase W2；
Add in the inner aqueous phase W1 in the oil phase O, ultrasound, obtains colostrum W1/O under ice bath；
It is added in outer aqueous phase W2 by the colostrum W1/O, is stirred under ice bath, obtain emulsion W1/O/W2；
The emulsion W1/O/W2 is added in the deionized water sodium chloride solution of 400mL10%, volatile residue is stirred at room temperature
Organic solvent collects microballoon by miillpore filter, is washed with deionized, vacuum freeze drying, is placed in 4 DEG C of preservations, must grow
Factor microballoon.
The grain size of the growth factor microballoon is 30 μm.
Embodiment 4
The present embodiment provides a kind of hydrocolloid oil yarn, concrete scheme is：
A kind of hydrocolloid oil yarn, by base material and hydrocolloid into being grouped as；
The base material is reticulated polyester fiber,
The hydrocolloid ingredient is prepared from the following raw materials in parts by weight：
10 parts of G1651,16 parts of sodium carboxymethylcellulose, 5 parts of growth factor microballoon, 5 parts of chitosan, atoleine 200
10 parts of part, 40 parts of vaseline and lanolin.
The preparation method of the hydrocolloid oil yarn of the present embodiment includes the following steps：
Each raw material is weighed by above-mentioned parts by weight；
By G1651, atoleine, vaseline and lanolin, soften in a kettle at a temperature of 200 DEG C 30 minutes,
Obtain mixture；
In the mixture, the sodium carboxymethylcellulose and chitosan, of the sodium carboxymethylcellulose are added in
Grain aperture is 75 μm.20min is mixed with the rotating speed of 100r/min, temperature is 100 DEG C, obtains fusant, vacuum defoamation；
The fusant after vacuum defoamation is coated on the reticulated polyester fiber, obtains base material net；
The concrete technology of coating is：The fusant is placed in the constant-temperature glue groove in double roller coating machine, the temperature in glue groove
Degree is maintained at 100 DEG C.Reticulated polyester fiber is uniformly covered with the applicator roll of one layer of fusant by first, is coated with one layer in advance
Fusant；Remove fusant extra in mesh in reticulated polyester fiber using second applicator roll, obtain base material net.Wherein,
The spacing of double roller is 2mm, coating speed 4.5m/min.
Growth factor microballoon is quantitatively made an addition to by not yet cooling base material by spray mode online, cooling, overlay film, shearing
And packaging, obtain hydrocolloid oil yarn D.
The growth factor microballoon is prepared using W/O/W double emulsion solvents volatility process.Specific preparation method is as follows：
20 μ g of epidermal growth factor, 50 μ L of seralbumin 5mg and polyethylene glycol 400 are added in 100 μ L deionized waters
(density 1.110g/L) obtains inner aqueous phase W1；Lactic acid/glycolic acid copolymers are added in 4mL dichloromethane/acetone mixture
100mg obtains oil phase O；1.5mg polyvinyl alcohol is dissolved in 100mL water, obtains polyvinyl alcohol water solution, as outer aqueous phase W2；
Add in the inner aqueous phase W1 in the oil phase O, ultrasound, obtains colostrum W1/O under ice bath；
It is added in outer aqueous phase W2 by the colostrum W1/O, is stirred under ice bath, obtain emulsion W1/O/W2；
The emulsion W1/O/W2 is added in the sodium chloride deionized water solution of 400mL10%, volatile residue is stirred at room temperature
Organic solvent collects microballoon by miillpore filter, is washed with deionized, vacuum freeze drying, is placed in 4 DEG C of preservations, must grow
Factor microballoon.
The grain size of the growth factor microballoon is 40 μm.
Comparative example 1
This comparative example provides a kind of hydrocolloid oil yarn, and raw material is substantially the same manner as Example 4, difference lies in：Growth is not added
Factor microballoon.
The preparation method of this comparative example hydrocolloid oil yarn is same as Example 4, obtains hydrocolloid oil yarn E.
Comparative example 2
This comparative example provides a kind of hydrocolloid oil yarn, and raw material is substantially the same manner as Example 4, difference lies in：SEBS is replaced
For rubber.
The preparation method of this comparative example hydrocolloid oil yarn is same as Example 4, obtains hydrocolloid oil yarn F.
Comparative example 3
This comparative example provides a kind of hydrocolloid oil yarn, and raw material is substantially the same manner as Example 4, difference lies in：It is not added with wool
Fat.
The preparation method of this comparative example hydrocolloid oil yarn is same as Example 4, obtains hydrocolloid oil yarn G.
Comparative example 4
This comparative example provides a kind of commercially available petrolatum gauze H.
Performance study
1st, hydrocolloid oil yarn biological property is studied
With reference to GB/T 16886.1-2001 BiologicalEvaluationofMedicalDevice part 1s：Evaluation and experiment, GB/T
The 10th part of 16886.10-2005 BiologicalEvaluationofMedicalDevices：Stimulation and delayed allergy experiment, GB/T
The 5th part of 16886.5-2003 BiologicalEvaluationofMedicalDevices：The relevant criterions such as vitro cytotoxicity test implement the present invention
4 hydrocolloid oil yarn sample of example carried out biology in terms of research.
(1) skin irritation is tested
Sample is taken by 3cm2The addition of/mL ratios meets the extraction medium that 10.3.4 is required in GB/T 16886.12-2005 and exists
Extraction (24 ± 2) h prepares leaching liquor under the conditions of (37 ± 1) DEG C, and test method is by GB/T 16886.10- after being filtered with funnel
Regulation in 2005 Appendix B B.2 carries out.As a result the rabbit skin primary stimulus index (PII) for being hydrocolloid oil yarn is 0, stingless
Swash.
(2) vitro cytotoxicity test
Sample is taken by 3cm2/ mL ratios add in cell culture fluid, and extraction (24 ± 2) h prepares leaching under the conditions of (37 ± 1) DEG C
Extract, test method is carried out by GB/T 16886.5-2003 8.2 regulation after being filtered with funnel.As a result it is hydrocolloid oil yarn
Cell-cytotoxic reaction averagely to score be 0, no cytotoxicity.
(3) delayed allergy is tested
Sample is taken by 3cm2The addition of/mL ratios meets the extraction medium that 10.3.4 is required in GB/T 16886.12-2005 and exists
Extraction (24 ± 2) h prepares leaching liquor under the conditions of (37 ± 1) DEG C, and test method is by GB/T 16886.10- after being filtered with funnel
The regulation of 7 chapters carries out in 2005.As a result the sensitivity response average score for being hydrocolloid oil yarn is 0, no sensitization.
2nd, hydrocolloid oil yarn effectiveness study
Skin ultrastructure is tested：
Animal：White big ear rabbit：Weight 2kg, male.
Animal model makes：Before on-test, 25% urethane is injected from rabbit auricular vein by 1g/kg, make animal into
Enter narcosis.Back unhairing preserved skin disinfection cuts 9 circular incisions along backbone both sides with scalpel, cuts off epidermis undertissue
To fascia, hemostasis, sterile gauze package, sub-cage rearing.
Medication：It performs the operation next day, after cleaning the surface of a wound with nitrofurazone, each 9 surface of a wound of back part of animal is divided into A-I nine
Group.Wherein, I groups are blank control group, without any processing；H groups stick petrolatum gauze；A-D is embodiment group, sticks implementation
Example hydrocolloid oil yarn；E-G is comparative example group, sticks comparative example hydrocolloid oil yarn.Change within three days a dressing.
Evaluation method：Wound area measures：Next day, the 7th day and the 14th day measure wound diameter and calculate respectively after operation
Area.
The surface of a wound measures：Postoperative 7th day, 9 groups of surface of a wound area was reduced, but wherein A-D groups reduce most apparent, E-G
Group area diminution is slower, and the diminution of H, I group area is most slow, and H groups have part granulation tissue progress mesh；Postoperative 14th day surface of a wound face
Product further reduces, and the amplitude and speed of diminution are still most apparent for D groups, the results are shown in Table 1.
1 surface of a wound area measurement (cm of table2,)
In E groups, comparative example 1 does not add in growth factor microballoon, weaker to the repairing effect of the surface of a wound.
In F groups, the compatibility of 2 rubber of comparative example and vaseline is bad.
In G groups, the Wound treatment ability more to sepage of comparative example 3 is bad.
3rd, antibacterial tests：
The freeze-drying strain of two kinds of experimental bacterias of staphylococcus aureus and pseudomonas aeruginosa will be activated, be inoculated in ordinary broth training
On the tablet for supporting base agar, cultivated 24 hours at 37 DEG C of temperature under aerobic conditions, remove supernatant, it is appropriate with nutrient broth
Thalline is diluted, adds in the hydrocolloid oil yarn (embodiment 4) of the present invention, 5,10,20,40 and 80min is incubated at normal temperatures, takes respectively
Go out 50 μ L to be coated with for tablet, culture is inverted for 24 hours at 37 DEG C of temperature, observe bacterium colony growing state；This hair is substituted with sterile water
Bright hydrocolloid oil yarn is as blank control.It the results are shown in Table 2.
2 bacteriostatic activity test result of table
As it can be seen that the embodiment of the present application has preferable antibiotic rate, to accelerating the reparation rate of the surface of a wound.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Embodiment described above only expresses the several embodiments of the present invention, and description is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of hydrocolloid oil yarn, which is characterized in that including base material and hydrocolloid ingredient；
The base material is reticulated polyester fiber；
The hydrocolloid ingredient includes the raw material of following parts by weight：
8-10 parts of thermoplastic elastomer (TPE), 16-30 parts of sodium carboxymethylcellulose, 1-5 parts of growth factor microballoon, 1-5 parts of chitosan, liquid
5-10 parts of 100-200 parts of body paraffin, 30-40 parts of vaseline and lanolin；
The content of growth factor is 0.01wt%-0.03wt% in the growth factor microballoon.
2. hydrocolloid oil yarn according to claim 1, which is characterized in that the weight of the growth factor microballoon and chitosan
Than for (1-2):1.
3. hydrocolloid oil yarn according to claim 1, which is characterized in that the atoleine, vaseline and lanolin
Weight ratio is (15-20)：(4-6)：1.
4. hydrocolloid oil yarn according to claim 1, which is characterized in that the growth factor microballoon is mainly by following weight
The raw material of number is prepared：
0.01-0.02 parts of growth factor, lactic acid/50-100 parts of glycolic acid copolymers, 1-5 parts of seralbumin and polyethylene glycol
400 0.05-0.1 parts and 1-1.5 parts of polyvinyl alcohol.
5. according to claim 1-4 any one of them hydrocolloid oil yarns, which is characterized in that the preparation of the growth factor microballoon
Method includes the following steps：
The growth factor, seralbumin and polyethylene glycol 400 are added in deionized water, obtains inner aqueous phase W1；In dichloromethane
Lactic acid/glycolic acid copolymers are added in alkane/acetone mixture, obtain oil phase O；Using the aqueous solution of polyvinyl alcohol as outer aqueous phase W2；
Add in the inner aqueous phase W1 in the oil phase O, ultrasound, obtains colostrum W1/O under ice bath；
It is added in outer aqueous phase W2 by the colostrum W1/O, is stirred under ice bath, obtain emulsion W1/O/W2；
The emulsion W1/O/W2, solvent flashing are added in sodium chloride solution, filtering obtains growth factor microballoon.
6. according to claim 1-4 any one of them hydrocolloid oil yarns, which is characterized in that the growth factor be selected from EGF,
The one or more of FGF, TGF, VEGF, PDGF.
7. according to claim 1-4 any one of them hydrocolloid oil yarns, which is characterized in that the thermoplastic elastomer (TPE) is selected from
The one or more of SBS, SIS, SEPS and SEBS.
8. hydrocolloid oil yarn according to claim 7, which is characterized in that G1650s of the SEBS selected from U.S. Kraton,
The one or more of G1651 and G1652.
9. according to claim 1-4 any one of them hydrocolloid oil yarns, which is characterized in that the grain size of the growth factor microballoon
It is 1 μm -40 μm；And/or
The particle aperture of the sodium carboxymethylcellulose is 20 μm -150 μm.
10. a kind of preparation method of claim 1-9 any one of them hydrocolloid oil yarn, which is characterized in that including following step
Suddenly：
Each raw material is weighed by the parts by weight of claim 1-9 any one of them hydrocolloid oil yarns；
The thermoplastic elastomer (TPE), atoleine, vaseline and lanolin are softened into 20-40min, temperature is 100-200 DEG C, is obtained
Mixture；
In the mixture, the sodium carboxymethylcellulose and chitosan are added in, is mixed, temperature is 100-120 DEG C, is obtained
Fusant, vacuum defoamation；
The fusant after vacuum defoamation is coated on the base material, obtains base material net；
The growth factor microballoon is sprayed on the net in base material, obtains hydrocolloid oil yarn.
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| CN109731151A (en) * | 2019-01-09 | 2019-05-10 | 西安交通大学医学院第一附属医院 | A kind of negative pressure drainage device and its application method |
| CN110974999A (en) * | 2019-12-18 | 2020-04-10 | 广州润虹医药科技股份有限公司 | Composition for resisting bacteria and promoting wound healing and medical hydrocolloid oily yarn thereof |
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