CN108126232B - Hydrocolloid oil yarn and preparation method thereof - Google Patents

Hydrocolloid oil yarn and preparation method thereof Download PDF

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Publication number
CN108126232B
CN108126232B CN201711489779.8A CN201711489779A CN108126232B CN 108126232 B CN108126232 B CN 108126232B CN 201711489779 A CN201711489779 A CN 201711489779A CN 108126232 B CN108126232 B CN 108126232B
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parts
growth factor
hydrocolloid
oil yarn
microballoon
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CN108126232A (en
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黄海艳
赵澎
车七石
刘少辉
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Guangzhou Rainhome Pharm and Tech Co Ltd
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Guangzhou Rainhome Pharm and Tech Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/34—Oils, fats, waxes or natural resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors

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Abstract

It include substrate and hydrocolloid ingredient the present invention relates to a kind of hydrocolloid oil yarn；The substrate is reticulated polyester fiber；The hydrocolloid ingredient includes the raw material of following parts by weight: 8-10 parts of thermoplastic elastomer (TPE), 16-30 parts of sodium carboxymethylcellulose, 1-5 parts of growth factor microballoon, 1-5 parts of chitosan, 100-200 parts of atoleine, 30-40 parts of vaseline and 5-10 parts of lanolin.The content of growth factor is 0.01wt%-0.03wt% in the growth factor microballoon.

Description

Hydrocolloid oil yarn and preparation method thereof
Technical field
The present invention relates to field of medical materials, more particularly to hydrocolloid oil yarn and preparation method thereof.
Background technique
Human skin can not only make one homoiostasis, while can also prevent the invasion of bacterium, microorganism.Work as skin When skin injury, under conditions of homeostasis is broken, medical dressing can give human body as a kind of medical material that cures the wound Certain necessary protection, reduces the extent of injury.Before skin recovery, good medical dressing temporary can play a part Skin blocks the effect of function, provides advantageous condition for the healing of wound.
Existing dressing speed of wound healing is slow, plays the role of surface of a wound drainage, covering and filling mostly, and healing Easy adhesion wound in the process, leads to bleeding, causes secondary injury, pain after patient's more change dressings.
Summary of the invention
Based on this, it is necessary in view of the above-mentioned problems, providing a kind of hydrocolloid oil yarn and preparation method thereof.
It is an object of the present invention to provide a kind of hydrocolloid oil yarns.
Specific technical solution is as follows:
A kind of hydrocolloid oil yarn, including substrate and hydrocolloid ingredient；
The substrate is reticulated polyester fiber；
The hydrocolloid ingredient includes the raw material of following parts by weight:
8-10 parts of thermoplastic elastomer (TPE), sodium carboxymethylcellulose 16-30,1-5 parts of growth factor microballoon, 1-5 parts of chitosan, 100-200 parts of atoleine, 30-40 parts of vaseline and 5-10 parts of lanolin.
The content of growth factor is 0.01wt%-0.02wt% in the growth factor microballoon.
The weight ratio of the growth factor microballoon and chitosan is (1-2) in one of the embodiments: 1.
The weight ratio of the atoleine, vaseline and lanolin is (15-20): (4- in one of the embodiments, 6): 1.
The growth factor microballoon includes following parts by weight raw material in one of the embodiments:
0.01-0.02 parts of growth factor, lactic acid/50-100 parts of glycolic acid copolymers, 1-5 parts of seralbumin and poly- second two 400 0.05-0.1 parts of alcohol.
The preparation method of the growth factor microballoon includes the following steps: in one of the embodiments,
The growth factor, seralbumin and polyethylene glycol 400 are added in deionized water, obtains inner aqueous phase W1；In two Lactic acid/glycolic acid copolymers are added in chloromethanes/acetone mixture, obtain oily phase O；Using polyvinyl alcohol water solution as outer aqueous phase W2；
The inner aqueous phase W1 is added in the oily phase O, ultrasound under ice bath obtains colostrum W1/O；
It is added in outer aqueous phase W2 by the colostrum W1/O, is stirred under ice bath, obtain emulsion W1/O/W2；
The emulsion W1/O/W2, solvent flashing are added in sodium chloride solution, filtering obtains growth factor microballoon.
The growth factor is selected from the one or more of EGF, FGF, TGF, VEGF, PDGF in one of the embodiments,.
The thermoplastic elastomer (TPE) is selected from one kind or several of SBS, SIS, SEPS and SEBS in one of the embodiments, Kind.
In one of the embodiments, the SEBS be selected from U.S. Kraton G1650, G1651 and G1652 one kind or It is several.
The partial size of the growth factor microballoon is 1 μm -40 μm in one of the embodiments,；And/or
The particle aperture of the sodium carboxymethylcellulose is 20 μm -150 μm.
It is a further object to provide the preparation methods of above-mentioned hydrocolloid oil yarn.
The specific technical proposal is:
A kind of preparation method of hydrocolloid oil yarn, comprising the following steps:
Each raw material is weighed by above-mentioned parts by weight；
The thermoplastic elastomer (TPE), atoleine, vaseline and lanolin are softened into 20-40min, temperature 100-200 DEG C, obtain mixture；
In the mixture, the sodium carboxymethylcellulose and chitosan is added, is mixed, temperature 100-120 DEG C, obtain fusant, vacuum defoamation；
The fusant after coating vacuum defoamation on the substrate, obtains substrate net；
The growth factor microballoon is sprayed on the net in substrate, obtains hydrocolloid oil yarn.
It the principle of the present invention and has the beneficial effect that:
Substrate is reticulated polyester fiber, good permeability, and have certain mechanical strength, the substances such as coating thermoplastic elastomer (TPE) Afterwards, on the one hand, make the soft easily curling of hydrocolloid oil yarn of the present invention and indeformable, to being difficult to fixed wound and have preferably comply with Property；On the other hand, thermoplastic elastomer (TPE) forms gel in reticulated polyester fiber surface, and granulation tissue is not easy to grow to fiber mesh In, and then it is not easy adhesion wound；Thermoplastic elastomer (TPE) and atoleine, vaseline and lanolin have good compatibility, and Skin-tolerant can be improved；A small amount of sodium carboxymethylcellulose can keep certain humidity in wound surface, which avoids enough Wound is dry, and CMC-Na is to the absorption of diffusate so that stickum becomes gel, so that can be painlessly after oily yarn use It is removed from wound；It is added to chitosan particle, plays good antibacterial action, is effectively protected the healing of wound；Growth because Sub- microballoon takes part in the whole process of wound healing and is wherein playing very important effect, the addition of growth factor microballoon The effect of improving hydrocolloid oil yarn wound healing effect.
Compared with existing scheme, the invention has the following advantages:
Above-mentioned hydrocolloid oil yarn, acts on wound surface, creates an existing humidity, and have antibacterial effect is simultaneous can promote The healing microenvironment of regeneration and restoration.Since the not viscous wound surface of its use and surrounding skin, more change dressings are painless It is bitter, without bleeding, extraneous tissue will not be damaged.
Further, the ratio of atoleine, vaseline and lanolin is controlled, the imbibition of hydrocolloid oil yarn of the present invention is improved Amount and penetrability can accelerate the healing of wound on the more surface of a wound of sepage；Control the ratio of growth factor microballoon and chitosan Example builds a more preferably repairing environment for wound, promotes wound healing and regeneration and restoration；
In addition, growth factor is not easy to save, it is prepared as growth factor microballoon, its storage stability can be improved.
Specific embodiment
Hydrocolloid oil yarn of the invention is described in further detail below in conjunction with specific embodiment.
SBS is Styrene-Butadiene-Styrene Block Copolymer；
SIS is styrene-isoprene-styrene block copolymer；
SEPS is styrene ethylene-propylene-styrene block copolymer；
SEBS is styrene-ethylene-butylene-styrene block copolymer
EGF (epidermal growth factor) growth factor includes epidermal growth factor；
FGF (fibroblast growth factor) fibroblast growth factor；
PDGF (platelet derived growth factor) platelet derived growth factor；
VEGF (human vascular endothelial growth factor) human vascular endothelial growth factor；
TGF (transforming growth factor) transforming growth factor.
The raw material used of the specific embodiment of the invention derives from commercially available.
Embodiment 1
The present embodiment provides a kind of hydrocolloid oil yarns, the specific scheme is that
A kind of hydrocolloid oil yarn, by substrate and hydrocolloid at being grouped as；
The substrate is reticulated polyester fiber,
The hydrocolloid ingredient is prepared from the following raw materials in parts by weight:
8 parts of G1651,30 parts of sodium carboxymethylcellulose, 1 part of growth factor microballoon, 1 part of chitosan, 100 parts of atoleine, 30 parts and 5 parts of lanolin of vaseline.
The preparation method of the hydrocolloid oil yarn of the present embodiment the following steps are included:
Each raw material is weighed by above-mentioned parts by weight；
By G1651, atoleine, vaseline and lanolin, 200 DEG C at a temperature of soften in a kettle 30 minutes, Obtain mixture；
In the mixture, the sodium carboxymethylcellulose and chitosan, of the sodium carboxymethylcellulose is added Grain aperture is 75 μm.20min is mixed with the revolving speed of 100r/min, temperature is 100 DEG C, obtains fusant, vacuum defoamation；
The fusant after coating vacuum defoamation on the reticulated polyester fiber, obtains substrate net；
Coating specifically comprises the processes of: the fusant is placed in the constant-temperature glue groove in double roller coating machine, the temperature in glue groove Degree is maintained at 100 DEG C.Reticulated polyester fiber is uniformly covered with the applicator roll of one layer of fusant by first, and one layer of coating in advance is molten Melt object；Remove fusant extra in mesh in reticulated polyester fiber using second applicator roll, obtains substrate net.Wherein, double The spacing of roller is 2mm, coating speed 4.5m/min.
Growth factor microballoon quantitatively made an addition into not yet cooling substrate by spray mode online, cooling, overlay film, shearing And packaging, obtain hydrocolloid oil yarn A.
The growth factor microballoon is prepared using W/O/W double emulsion solvent volatility process.It is specific the preparation method is as follows:
10 μ g of epidermal growth factor, 100 μ of seralbumin 1mg and polyethylene glycol 400 are added in 100 μ L deionized waters L (density 1.110g/L) obtains inner aqueous phase W1；Lactic acid/glycolic acid copolymers are added in 4mL methylene chloride/acetone mixture 50mg obtains oily phase O；1.5mg polyvinyl alcohol is dissolved in 100mL water, polyvinyl alcohol water solution is obtained, as outer aqueous phase W2；
The inner aqueous phase W1 is added in the oily phase O, ultrasound under ice bath obtains colostrum W1/O；
It is added in outer aqueous phase W2 by the colostrum W1/O, is stirred under ice bath, obtain emulsion W1/O/W2；
The emulsion W1/O/W2 is added in the sodium chloride deionized water solution of 400mL10%, volatile residue is stirred at room temperature Organic solvent collects microballoon by miillpore filter, is washed with deionized, vacuum freeze drying, is placed in 4 DEG C of preservations, must grow Factor microballoon.
The partial size of the growth factor microballoon is 10 μm.
Embodiment 2
The present embodiment provides a kind of hydrocolloid oil yarns, the specific scheme is that
A kind of hydrocolloid oil yarn, by substrate and hydrocolloid at being grouped as；
The substrate is reticulated polyester fiber,
The hydrocolloid ingredient is prepared from the following raw materials in parts by weight:
9 parts of G1651,25 parts of sodium carboxymethylcellulose, 3 parts of growth factor microballoon, 3 parts of chitosan, 130 parts of atoleine, 30 parts and 7 parts of lanolin of vaseline.
The preparation method of the hydrocolloid oil yarn of the present embodiment the following steps are included:
Each raw material is weighed by above-mentioned parts by weight；
By G1651, atoleine, vaseline and lanolin, 200 DEG C at a temperature of soften in a kettle 30 minutes, Obtain mixture；
In the mixture, the sodium carboxymethylcellulose and chitosan, of the sodium carboxymethylcellulose is added Grain aperture is 75 μm.20min is mixed with the revolving speed of 100r/min, temperature is 100 DEG C, obtains fusant, vacuum defoamation；
The fusant after coating vacuum defoamation on the reticulated polyester fiber, obtains substrate net；
Coating specifically comprises the processes of: the fusant is placed in the constant-temperature glue groove in double roller coating machine, the temperature in glue groove Degree is maintained at 100 DEG C.Reticulated polyester fiber is uniformly covered with the applicator roll of one layer of fusant by first, is coated with one layer in advance Fusant；Remove fusant extra in mesh in reticulated polyester fiber using second applicator roll, obtains substrate net.Wherein, The spacing of double roller is 2mm, coating speed 4.5m/min.
Growth factor microballoon quantitatively made an addition into not yet cooling substrate by spray mode online, cooling, overlay film, shearing And packaging, obtain hydrocolloid oil yarn B.
The growth factor microballoon is prepared using W/O/W double emulsion solvent volatility process.It is specific the preparation method is as follows:
10 μ g of epidermal growth factor, 70 μ L of seralbumin 2mg and polyethylene glycol 400 are added in 100 μ L deionized waters (density 1.110g/L) obtains inner aqueous phase W1；Lactic acid/glycolic acid copolymers are added in 4mL methylene chloride/acetone mixture 60mg obtains oily phase O；1.5mg polyvinyl alcohol is dissolved in 100mL water, polyvinyl alcohol water solution is obtained, as outer aqueous phase W2；
The inner aqueous phase W1 is added in the oily phase O, ultrasound under ice bath obtains colostrum W1/O；
It is added in outer aqueous phase W2 by the colostrum W1/O, is stirred under ice bath, obtain emulsion W1/O/W2；
The emulsion W1/O/W2 is added in the sodium chloride deionized water solution of 400mL10%, volatile residue is stirred at room temperature Organic solvent collects microballoon by miillpore filter, is washed with deionized, vacuum freeze drying, is placed in 4 DEG C of preservations, must grow Factor microballoon.
The partial size of the growth factor microballoon is 20 μm.
Embodiment 3
The present embodiment provides a kind of hydrocolloid oil yarns, the specific scheme is that
A kind of hydrocolloid oil yarn, by substrate and hydrocolloid at being grouped as；
The substrate is reticulated polyester fiber,
The hydrocolloid ingredient is prepared from the following raw materials in parts by weight:
10 parts of G1651,20 parts of sodium carboxymethylcellulose, 4 parts of growth factor microballoon, 4 parts of chitosan, atoleine 150 Part, 35 parts of vaseline and 9 parts of lanolin.
The preparation method of the hydrocolloid oil yarn of the present embodiment the following steps are included:
Each raw material is weighed by above-mentioned parts by weight；
By G1651, atoleine, vaseline and lanolin, 200 DEG C at a temperature of soften in a kettle 30 minutes, Obtain mixture；
In the mixture, the sodium carboxymethylcellulose and chitosan, of the sodium carboxymethylcellulose is added Grain aperture is 75 μm.20min is mixed with the revolving speed of 100r/min, temperature is 100 DEG C, obtains fusant, vacuum defoamation；
The fusant after coating vacuum defoamation on the reticulated polyester fiber, obtains substrate net；
Coating specifically comprises the processes of: the fusant is placed in the constant-temperature glue groove in double roller coating machine, the temperature in glue groove Degree is maintained at 100 DEG C.Reticulated polyester fiber is uniformly covered with the applicator roll of one layer of fusant by first, is coated with one layer in advance Fusant；Remove fusant extra in mesh in reticulated polyester fiber using second applicator roll, obtains substrate net.Wherein, The spacing of double roller is 2mm, coating speed 4.5m/min.
Growth factor microballoon quantitatively made an addition into not yet cooling substrate by spray mode online, cooling, overlay film, shearing And packaging, obtain hydrocolloid oil yarn C.
The growth factor microballoon is prepared using W/O/W double emulsion solvent volatility process.It is specific the preparation method is as follows:
20 μ g of epidermal growth factor, 60 μ L of seralbumin 3mg and polyethylene glycol 400 are added in 100 μ L deionized waters (density 1.110g/L) obtains inner aqueous phase W1；Lactic acid/glycolic acid copolymers are added in 4mL methylene chloride/acetone mixture 80mg obtains oily phase O；1.5mg polyvinyl alcohol is dissolved in 100mL water, polyvinyl alcohol water solution is obtained, as outer aqueous phase W2；
The inner aqueous phase W1 is added in the oily phase O, ultrasound under ice bath obtains colostrum W1/O；
It is added in outer aqueous phase W2 by the colostrum W1/O, is stirred under ice bath, obtain emulsion W1/O/W2；
The emulsion W1/O/W2 is added in the deionized water sodium chloride solution of 400mL10%, volatile residue is stirred at room temperature Organic solvent collects microballoon by miillpore filter, is washed with deionized, vacuum freeze drying, is placed in 4 DEG C of preservations, must grow Factor microballoon.
The partial size of the growth factor microballoon is 30 μm.
Embodiment 4
The present embodiment provides a kind of hydrocolloid oil yarns, the specific scheme is that
A kind of hydrocolloid oil yarn, by substrate and hydrocolloid at being grouped as；
The substrate is reticulated polyester fiber,
The hydrocolloid ingredient is prepared from the following raw materials in parts by weight:
10 parts of G1651,16 parts of sodium carboxymethylcellulose, 5 parts of growth factor microballoon, 5 parts of chitosan, atoleine 200 Part, 40 parts of vaseline and 10 parts of lanolin.
The preparation method of the hydrocolloid oil yarn of the present embodiment the following steps are included:
Each raw material is weighed by above-mentioned parts by weight；
By G1651, atoleine, vaseline and lanolin, 200 DEG C at a temperature of soften in a kettle 30 minutes, Obtain mixture；
In the mixture, the sodium carboxymethylcellulose and chitosan, of the sodium carboxymethylcellulose is added Grain aperture is 75 μm.20min is mixed with the revolving speed of 100r/min, temperature is 100 DEG C, obtains fusant, vacuum defoamation；
The fusant after coating vacuum defoamation on the reticulated polyester fiber, obtains substrate net；
Coating specifically comprises the processes of: the fusant is placed in the constant-temperature glue groove in double roller coating machine, the temperature in glue groove Degree is maintained at 100 DEG C.Reticulated polyester fiber is uniformly covered with the applicator roll of one layer of fusant by first, is coated with one layer in advance Fusant；Remove fusant extra in mesh in reticulated polyester fiber using second applicator roll, obtains substrate net.Wherein, The spacing of double roller is 2mm, coating speed 4.5m/min.
Growth factor microballoon quantitatively made an addition into not yet cooling substrate by spray mode online, cooling, overlay film, shearing And packaging, obtain hydrocolloid oil yarn D.
The growth factor microballoon is prepared using W/O/W double emulsion solvent volatility process.It is specific the preparation method is as follows:
20 μ g of epidermal growth factor, 50 μ L of seralbumin 5mg and polyethylene glycol 400 are added in 100 μ L deionized waters (density 1.110g/L) obtains inner aqueous phase W1；Lactic acid/glycolic acid copolymers are added in 4mL methylene chloride/acetone mixture 100mg obtains oily phase O；1.5mg polyvinyl alcohol is dissolved in 100mL water, polyvinyl alcohol water solution is obtained, as outer aqueous phase W2；
The inner aqueous phase W1 is added in the oily phase O, ultrasound under ice bath obtains colostrum W1/O；
It is added in outer aqueous phase W2 by the colostrum W1/O, is stirred under ice bath, obtain emulsion W1/O/W2；
The emulsion W1/O/W2 is added in the sodium chloride deionized water solution of 400mL10%, volatile residue is stirred at room temperature Organic solvent collects microballoon by miillpore filter, is washed with deionized, vacuum freeze drying, is placed in 4 DEG C of preservations, must grow Factor microballoon.
The partial size of the growth factor microballoon is 40 μm.
Comparative example 1
This comparative example provides a kind of hydrocolloid oil yarn, and raw material is substantially the same manner as Example 4, and difference is: not adding growth Factor microballoon.
The preparation method of this comparative example hydrocolloid oil yarn is same as Example 4, obtains hydrocolloid oil yarn E.
Comparative example 2
This comparative example provides a kind of hydrocolloid oil yarn, and raw material is substantially the same manner as Example 4, and difference is: SEBS is replaced For rubber.
The preparation method of this comparative example hydrocolloid oil yarn is same as Example 4, obtains hydrocolloid oil yarn F.
Comparative example 3
This comparative example provides a kind of hydrocolloid oil yarn, and raw material is substantially the same manner as Example 4, and difference is: being not added with wool Rouge.
The preparation method of this comparative example hydrocolloid oil yarn is same as Example 4, obtains hydrocolloid oil yarn G.
Comparative example 4
This comparative example provides a kind of commercially available petrolatum gauze H.
Performance study
1, hydrocolloid oil yarn biological property is studied
Referring to GB/T 16886.1-2001 BiologicalEvaluationofMedicalDevice part 1: evaluation and test, GB/T 16886.10-2005 the 10th part of BiologicalEvaluationofMedicalDevice: stimulation and delayed allergy test, GB/T The 5th part of 16886.5-2003 BiologicalEvaluationofMedicalDevice: the relevant criterions such as vitro cytotoxicity test implement the present invention 4 hydrocolloid oil yarn sample of example carried out biology in terms of research.
(1) skin irritation is tested
Take sample by 3cm2The addition of/mL ratio meets the extraction medium that 10.3.4 is required in GB/T 16886.12-2005 and exists Extraction (24 ± 2) h prepares leaching liquor under the conditions of (37 ± 1) DEG C, and test method is by GB/T 16886.10- after being filtered with funnel Regulation in 2005 Appendix B B.2 carries out.As a result the rabbit skin primary stimulus index (PII) for being hydrocolloid oil yarn is 0, stingless Swash.
(2) vitro cytotoxicity test
Take sample by 3cm2Cell culture fluid is added in/mL ratio, and (24 ± 2) h preparation leaching is extracted under the conditions of (37 ± 1) DEG C Extract, test method is carried out by GB/T 16886.5-2003 8.2 regulation after being filtered with funnel.It as a result is hydrocolloid oil yarn Cell-cytotoxic reaction averagely score as 0, no cytotoxicity.
(3) delayed allergy is tested
Take sample by 3cm2The addition of/mL ratio meets the extraction medium that 10.3.4 is required in GB/T 16886.12-2005 and exists Extraction (24 ± 2) h prepares leaching liquor under the conditions of (37 ± 1) DEG C, and test method is by GB/T 16886.10- after being filtered with funnel The regulation of 7 chapters carries out in 2005.As a result the sensitivity response average score for being hydrocolloid oil yarn is 0, no sensitization.
2, hydrocolloid oil yarn effectiveness study
Skin ultrastructure test:
Animal: white big ear rabbit: weight 2kg, male.
Animal model production: before on-test, inject 25% urethane from rabbit auricular vein by 1g/kg, make animal into Enter narcosis.Unhairing preserved skin disinfection in back cuts 9 circular incisions along backbone two sides with scalpel, cuts off epidermis undertissue To fascia, hemostasis, sterile gauze package, sub-cage rearing.
Medication: 9 surface of a wound of each back part of animal are divided into A-I nine after cleaning the surface of a wound with nitrofurazone by operation next day Group.Wherein, I group is blank control group, without any processing；H group sticks petrolatum gauze；A-D is embodiment group, sticks implementation Example hydrocolloid oil yarn；E-G is comparative example group, sticks comparative example hydrocolloid oil yarn.Change within three days a dressing.
Evaluation method: wound area measurement: next day, the 7th day and the 14th day measure wound diameter respectively and calculate after operation Area.
Surface of a wound measurement: postoperative 7th day, 9 groups of surface of a wound area was reduced, but wherein A-D group reduces most obvious, E-G Group area diminution is slower, and the diminution of H, I group area is most slow, and H group has part granulation tissue progress mesh；Postoperative 14th day surface of a wound face Product further reduces, and the amplitude and speed of diminution are still that D group is most obvious, the results are shown in Table 1.
1 surface of a wound area measurement (cm of table2,)
In E group, growth factor microballoon is not added for comparative example 1, weaker to the repairing effect of the surface of a wound.
In F group, the compatibility of 2 rubber of comparative example and vaseline is bad.
In G group, the Wound treatment ability more to sepage of comparative example 3 is bad.
3, antibacterial tests:
The freeze-drying strain of two kinds of experimental bacterias of staphylococcus aureus and pseudomonas aeruginosa will be activated, is inoculated in ordinary broth training On the plate for supporting base agar, is cultivated 24 hours at 37 DEG C of temperature under aerobic conditions, remove supernatant, it is appropriate with nutrient broth Thallus is diluted, hydrocolloid oil yarn (embodiment 4) of the invention is added, 5,10,20,40 and 80min is incubated at normal temperature, takes respectively 50 μ L are coated with for plate out, are inverted culture for 24 hours at 37 DEG C of temperature, observe bacterium colony growing state；This hair is substituted with sterile water Bright hydrocolloid oil yarn is as blank control.It the results are shown in Table 2.
2 bacteriostatic activity test result of table
As it can be seen that the embodiment of the present application has preferable antibiotic rate, to the reparation rate for accelerating the surface of a wound.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention Protect range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.

Claims (10)

1. a kind of hydrocolloid oil yarn, which is characterized in that including substrate and hydrocolloid ingredient；
The substrate is reticulated polyester fiber；
The hydrocolloid ingredient includes the raw material of following parts by weight:
8-10 parts of thermoplastic elastomer (TPE), 16-30 parts of sodium carboxymethylcellulose, 1-5 parts of growth factor microballoon, 1-5 parts of chitosan, liquid 100-200 parts of body paraffin, 30-40 parts of vaseline and 5-10 parts of lanolin；
The content of growth factor is 0.01wt%-0.03wt% in the growth factor microballoon；
The thermoplastic elastomer (TPE) is SEBS.
2. hydrocolloid oil yarn according to claim 1, which is characterized in that the weight of the growth factor microballoon and chitosan Than for (1-2): 1.
3. hydrocolloid oil yarn according to claim 1, which is characterized in that the atoleine, vaseline and lanolin Weight ratio is (15-20): (4-6): 1.
4. hydrocolloid oil yarn according to claim 1, which is characterized in that the growth factor microballoon is mainly by following weight The raw material of number is prepared:
0.01-0.02 parts of growth factor, lactic acid/50-100 parts of glycolic acid copolymers, 1-5 parts of seralbumin and polyethylene glycol 400 0.05-0.1 parts and polyvinyl alcohol 1-1.5 parts.
5. hydrocolloid oil yarn according to claim 1-4, which is characterized in that the preparation of the growth factor microballoon Method includes the following steps:
The growth factor, seralbumin and polyethylene glycol 400 are added in deionized water, obtains inner aqueous phase W1；In dichloromethane Lactic acid/glycolic acid copolymers are added in alkane/acetone mixture, obtain oily phase O；Using the aqueous solution of polyvinyl alcohol as outer aqueous phase W2；
The inner aqueous phase W1 is added in the oily phase O, ultrasound under ice bath obtains colostrum W1/O；
It is added in outer aqueous phase W2 by the colostrum W1/O, is stirred under ice bath, obtain emulsion W1/O/W2；
The emulsion W1/O/W2, solvent flashing are added in sodium chloride solution, filtering obtains growth factor microballoon.
6. hydrocolloid oil yarn according to claim 1-4, which is characterized in that the growth factor be selected from EGF, The one or more of FGF, TGF, VEGF, PDGF.
7. hydrocolloid oil yarn according to claim 1, which is characterized in that the SEBS be selected from U.S. Kraton G1650, The one or more of G1651 and G1652.
8. hydrocolloid oil yarn according to claim 1-4, which is characterized in that the partial size of the growth factor microballoon It is 1 μm -40 μm.
9. hydrocolloid oil yarn according to claim 1-4, which is characterized in that of the sodium carboxymethylcellulose Grain aperture is 20 μm -150 μm.
10. a kind of preparation method of the described in any item hydrocolloid oil yarns of claim 1-9, which is characterized in that including following step It is rapid:
Each raw material is weighed by the parts by weight of the described in any item hydrocolloid oil yarns of claim 1-9；
The thermoplastic elastomer (TPE), atoleine, vaseline and lanolin are softened into 20-40min, temperature is 100-200 DEG C, is obtained Mixture；
In the mixture, the sodium carboxymethylcellulose and chitosan is added, is mixed, temperature is 100-120 DEG C, is obtained Fusant, vacuum defoamation；
The fusant after coating vacuum defoamation on the substrate, obtains substrate net；
The growth factor microballoon is sprayed on the net in substrate, obtains hydrocolloid oil yarn.
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