CN108126109A - Wound burn bacteriostatic and its processing method - Google Patents

Wound burn bacteriostatic and its processing method Download PDF

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CN108126109A
CN108126109A CN201711496989.XA CN201711496989A CN108126109A CN 108126109 A CN108126109 A CN 108126109A CN 201711496989 A CN201711496989 A CN 201711496989A CN 108126109 A CN108126109 A CN 108126109A
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acid
wound
tube
bacteriostatic
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陈可礼
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Guangdong Euler Pharmaceutical Co Ltd
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Guangdong Euler Pharmaceutical Co Ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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Abstract

The invention discloses a kind of wound burn bacteriostatics, include the component of following parts by weight：50~300 parts of tea-seed oil, 10~20 parts of Radix Angelicae Sinensis, 15~30 parts of beeswax, 1~2 part of red lead, 5~10 parts of blood tone tablet, 5~10 parts of the bletilla striata, 0.5~1 part of organic acid rare-earth salts, 2~5 parts of modified carbon nano-tube, 0.2~0.5 part of nano oxidized silver powder.The invention also discloses the processing methods of this coating, (a) Radix Angelicae Sinensis, red lead, blood tone tablet, the bletilla striata, organic acid rare-earth salts, modified carbon nano-tube, nano oxidized silver powder are added in organic solvent, 0.5 3h is stirred with the rate of 200 2000rpm in the ball mill at room temperature, forms mixed-powder；(b) mixed-powder that step (a) is formed is added to beeswax in tea-seed oil and be sufficiently mixed, ultrasonic disperse 2~3 hours, and with the rate stirring of 100 300rpm until being uniformly mixing to obtain final wound burn bacteriostatic.The wound burn bacteriostatic of the present invention it is active it is high, curative effect is fast, wound without scar, usage amount is few, cheap the advantages of.

Description

Wound burn bacteriostatic and its processing method
Technical field
The present invention relates to Chinese patent drug, more particularly, to a kind of activity is high, curative effect is fast, wound without scar, usage amount is few, price Cheap wound burn bacteriostatic and its processing method.
Background technology
Depth wound and burn are mostly happened at the skin surface and deep tissues of human body, and wound and burn easily cause thin Bacterium infection, body fluid extravasation, leaves scar, is difficult to heal severe pain, can threat to life when serious.Treatment wound burn at present Types of drugs is more, mainly there is 2 classes：The first kind is chemical synthesis drug, such as flamazine etc., these drugs pair Treatment burn and scald has certain curative effect, but there are problems and deficiency：First, elimination Beancurd sheet and bad tissue are slow, trauma surface infestation machine Rate increases；Second is that incrustation is slow, the loss that moisturizes and infection；Third, patient is to cause pain in medication；Fourth, medical expense height. Second class is Chinese medicine preparation drug, such as jingwanhong soft plaster etc., this kind of drug, which burns to treatment wound, certain curative effect, but there is also Some problem and shortage：First, the raw material of drug, simply by simply being pulverized and mixed to obtain, cause seldom by pretreatment Drug molecule is difficult to Transdermal absorption, and bioavilability causes patient to restore slow than relatively low；Second is that times for spraying is relatively more, and Dosage is big；Third, price is more expensive, general patient is caused to be difficult to bear.
Invention content
To solve the above problems, the purpose of the present invention is to provide a kind of activity is high, curative effect is fast, wound is without scar, use Amount less, cheap wound burn bacteriostatic and its processing method.
The present invention realized by following technical measures, and a kind of wound is burnt bacteriostatic, includes the group of following parts by weight Part：50~300 parts of tea-seed oil, 10~20 parts of Radix Angelicae Sinensis, 15~30 parts of beeswax, 1~2 part of red lead, 5~10 parts of blood tone tablet, the bletilla striata 5~10 Part, 0.5~1 part of organic acid rare-earth salts, 2~5 parts of modified carbon nano-tube, 0.2~0.5 part of nano oxidized silver powder.
As a kind of preferred embodiment, 150~200 parts of tea-seed oil, 15~18 parts of Radix Angelicae Sinensis, 20~22 parts of beeswax, 1 part of red lead, 7~8 parts of blood tone tablet, 7~8 parts of the bletilla striata, 0.6 part of organic acid rare-earth salts, 3~4 parts of modified carbon nano-tube, nano oxidized silver powder 0.3 Part.
As a kind of preferred embodiment, the organic acid rare-earth salts is cesium formate, cerous acetate, butyric acid cerium, valeric acid cerium, different pungent It is one or more in sour cerium, maleic acid cerium, fumaric acid cerium, benzene sulfonic acid cerium and cerous tarate.
As a kind of preferred embodiment, the organic acid rare-earth salts is by formic acid, acetic acid, butyric acid, valeric acid, isooctyl acid, Malaysia Acid, fumaric acid, benzene sulfonic acid or tartaric acid sodium salt react and be made with cerous nitrate.
As a kind of preferred embodiment, the antibacterial medicines are gelling agent, which further includes the system of following weight parts Standby raw material：2~20 parts of carbomer, 200~450 parts of moisturizer；Wherein, the moisturizer is the mixture of glycerine and lanolin, The weight ratio of the glycerine and lanolin is 1.0~2.5：1.0~2.0.
As a kind of preferred embodiment, the processing method of the modified carbon nano-tube includes the following steps：
(1) by single-walled carbon nanotube powder in dense H2SO4With dense HNO3Nitration mixture in 60 DEG C acidification 1-4h, centrifuged after reaction It cleans to neutrality；
(2) single-walled carbon nanotube, the thionyl chloride ultrasonic disperse 2~3 in enough absolute ethyl alcohols that acidification was cleaned are small When, it is then stirred to react at a temperature of 70 DEG C~100 DEG C 20~30 hours, vacuum distillation removes thionyl chloride, filters to obtain solid Object is washed with distilled water, and vacuum drying obtains acyl chlorides carbon nano tube；
(3) by acyl chlorides carbon nano tube, sodium sulfanilate in enough absolute ethyl alcohols 10~20 points of ultrasonic disperse Clock is stirred to react 18~36 hours at 60 DEG C~80 DEG C, after reaction solution is cooled to room temperature, filters to obtain solid content distillation Water washing, vacuum drying, obtains modified carbon nano-tube.
50~300 parts of tea-seed oil, 10~20 parts of Radix Angelicae Sinensis, 15~30 parts of beeswax, 1~2 part of red lead, 5~10 parts of blood tone tablet, the bletilla striata 5~10 parts, 0.5~1 part of organic acid rare-earth salts, 2~5 parts of modified carbon nano-tube, 0.2~0.5 part of nano oxidized silver powder
The invention also discloses a kind of processing methods of wound burn bacteriostatic, are prepared by following steps：
(a) by 10~20 parts of the Radix Angelicae Sinensis of parts by weight, 1~2 part of red lead, 5~10 parts of blood tone tablet, 5~10 parts of the bletilla striata, organic acid It is 20 that 0.5~1 part of root rare-earth salts, 2~5 parts of modified carbon nano-tube, 0.2~0.5 part of nano oxidized silver powder, which are added to parts by weight, In~80 parts of organic solvent, 0.5-3h is stirred with the rate of 200-2000rpm in the ball mill at room temperature, forms mixed powder End；
(b) mixed-powder that step (a) is formed is added to 15~30 parts of beeswax in 50~300 parts of tea-seed oil and filled Divide mixing, ultrasonic disperse 2~3 hours, and burnt with the rate stirring of 100-300rpm until being uniformly mixing to obtain final wound Hinder bacteriostatic.
As a kind of preferred embodiment, the processing method of the modified carbon nano-tube includes the following steps：
(1) by single-walled carbon nanotube powder in dense H2SO4With dense HNO3Nitration mixture in 60 DEG C acidification 1-4h, centrifuged after reaction It cleans to neutrality；
(2) single-walled carbon nanotube, the thionyl chloride ultrasonic disperse 2~3 in enough absolute ethyl alcohols that acidification was cleaned are small When, it is then stirred to react at a temperature of 70 DEG C~100 DEG C 20~30 hours, vacuum distillation removes thionyl chloride, filters to obtain solid Object is washed with distilled water, and vacuum drying obtains acyl chlorides carbon nano tube；
(3) by acyl chlorides carbon nano tube, sodium sulfanilate in enough absolute ethyl alcohols 10~20 points of ultrasonic disperse Clock is stirred to react 18~36 hours at 60 DEG C~80 DEG C, after reaction solution is cooled to room temperature, filters to obtain solid content distillation Water washing, vacuum drying, obtains modified carbon nano-tube.
As a kind of preferred embodiment, the organic solvent for be 2~10 containing carbon number lower alkyl alcohol.
The present invention is dilute due to increasing organic acid in tea-seed oil, Radix Angelicae Sinensis, beeswax, red lead, blood tone tablet and the formula of the bletilla striata Earth salt, modified carbon nano-tube and nano oxidized silver powder, and the technique for passing through ball milling and ultrasonic disperse so that this formula can created Hinder the growth for inhibiting microorganism in burn treating, diminish inflammation, reduce the deposition of melanin.The present invention has the effect of antibacterial anti-inflammatory Fruit can efficiently control and prevent to infect；And can rationally solve the problems, such as the body fluid exudation of wound burn, greatly shorten treatment Time, due to controlling body fluid exudation, after surface of a wound incrustation comes off, neoplastic skin is smooth, it is flexible, without scar.
Specific embodiment
The present invention is described in further detail with reference to embodiment.
A kind of wound burn bacteriostatic includes the component of following parts by weight：50~300 parts of tea-seed oil, Radix Angelicae Sinensis 10~20 Part, 5~10 parts of the bletilla striata, 0.5~1 part of organic acid rare-earth salts, changes 15~30 parts of beeswax, 1~2 part of red lead, 5~10 parts of blood tone tablet 2~5 parts of carbon nanotube of property, 0.2~0.5 part of nano oxidized silver powder.
It through the following steps that prepare：
(a) by 10~20 parts of the Radix Angelicae Sinensis of parts by weight, 1~2 part of red lead, 5~10 parts of blood tone tablet, 5~10 parts of the bletilla striata, organic acid It is 20 that 0.5~1 part of root rare-earth salts, 2~5 parts of modified carbon nano-tube, 0.2~0.5 part of nano oxidized silver powder, which are added to parts by weight, In~80 parts of organic solvent, 0.5-3h is stirred with the rate of 200-2000rpm in the ball mill at room temperature, forms mixed powder End；
(b) mixed-powder that step (a) is formed is added to 15~30 parts of beeswax in 50~300 parts of tea-seed oil and filled Divide mixing, ultrasonic disperse 2~3 hours, and burnt with the rate stirring of 100-300rpm until being uniformly mixing to obtain final wound Hinder bacteriostatic.
This wound burns bacteriostatic due to being increased in tea-seed oil, Radix Angelicae Sinensis, beeswax, red lead, blood tone tablet and the formula of the bletilla striata Organic acid rare-earth salts, modified carbon nano-tube and nano oxidized silver powder, and the technique for passing through ball milling and ultrasonic disperse so that originally match Side can inhibit the growth of microorganism in wound burn treating, diminish inflammation, reduce the deposition of melanin.The burn suppression of this wound Bacterium medicine has the effect of antibacterial anti-inflammatory, can efficiently control and prevent to infect；And it can rationally solve the body fluid exudation of wound burn Problem greatly shortens treatment time, and due to controlling body fluid exudation, after surface of a wound incrustation comes off, neoplastic skin is smooth, has bullet Property, without scar.
In the wound burn bacteriostatic of an embodiment, organic acid is specifically also possible that on the basis of technical solution in front Root rare-earth salts is cesium formate, cerous acetate, butyric acid cerium, valeric acid cerium, isooctyl acid cerium, maleic acid cerium, fumaric acid cerium, benzene sulfonic acid cerium and wine It is one or more in stone acid cerium.
In the wound burn bacteriostatic of an embodiment, organic acid is specifically also possible that on the basis of technical solution in front Root rare-earth salts by formic acid, acetic acid, butyric acid, valeric acid, isooctyl acid, maleic acid, fumaric acid, benzene sulfonic acid or tartaric acid sodium salt and nitric acid Cerium reaction is made.
In the wound burn bacteriostatic of an embodiment, carbon modified is specifically also possible that on the basis of technical solution in front The processing method of nanotube, includes the following steps：
(1) by single-walled carbon nanotube powder in dense H2SO4With dense HNO3Nitration mixture in 60 DEG C acidification 1-4h, centrifuged after reaction It cleans to neutrality；
(2) single-walled carbon nanotube, the thionyl chloride ultrasonic disperse 2~3 in enough absolute ethyl alcohols that acidification was cleaned are small When, it is then stirred to react at a temperature of 70 DEG C~100 DEG C 20~30 hours, vacuum distillation removes thionyl chloride, filters to obtain solid Object is washed with distilled water, and vacuum drying obtains acyl chlorides carbon nano tube；
(3) by acyl chlorides carbon nano tube, sodium sulfanilate in enough absolute ethyl alcohols 10~20 points of ultrasonic disperse Clock is stirred to react 18~36 hours at 60 DEG C~80 DEG C, after reaction solution is cooled to room temperature, filters to obtain solid content distillation Water washing, vacuum drying, obtains modified carbon nano-tube.Inventor has found that the carbon modified prepared by this method is received in an experiment More other carbon nanotubes have the effect for preferably absorbing body fluid, and can improve the activity of various Chinese medicines to mitron in practical applications Effect.
In the wound burn bacteriostatic of an embodiment, specifically it is also possible that on the basis of technical solution in front organic molten The lower alkyl alcohol that it is 2~10 containing carbon number that agent, which is,.
Embodiment 1
A kind of antibacterial ointment of wound burn includes the component of following parts by weight：200 parts of tea-seed oil, 15 parts of Radix Angelicae Sinensis, beeswax 20 parts, 1 part of red lead, 7 parts of blood tone tablet, 7 parts of the bletilla striata, 0.6 part of organic acid rare-earth salts, 3 parts of modified carbon nano-tube, nano oxidized silver powder 0.3 part, 10 parts of carbomer, 300 parts of moisturizer；Wherein, mixture of the moisturizer for glycerine and lanolin, the glycerine with The weight ratio of lanolin is 1.0~2.5：1.0~2.0.
It through the following steps that prepare：
(a) by 15 parts of the Radix Angelicae Sinensis of parts by weight, 1 part of red lead, 7 parts of blood tone tablet, 7 parts of the bletilla striata, 0.6 part of organic acid rare-earth salts, 3 parts of modified carbon nano-tube, 0.3 part of nano oxidized silver powder are added in the organic solvent that parts by weight are 60 parts, at room temperature in ball 2.5h is stirred with the rate of 1000rpm in grinding machine, forms mixed-powder；
(b) mixed-powder that step (a) is formed is added to 20 parts of beeswax in 200 parts of tea-seed oil and is sufficiently mixed, Ultrasonic disperse 2~3 hours, and with the rate stirring of 100-300rpm up to adding 10 parts of carbomer, moisturizing after stirring evenly 300 parts of agent；The final antibacterial ointment of wound burn is obtained after packing.
Embodiment 2
A kind of antibacterial ointment of wound burn includes the component of following parts by weight：150 parts of tea-seed oil, 18 parts of Radix Angelicae Sinensis, beeswax 22 parts, 1.5 parts of red lead, 8 parts of blood tone tablet, 8 parts of the bletilla striata, 0.8 part of organic acid rare-earth salts, 4 parts of modified carbon nano-tube, nano phase ag_2 o 0.4 part of powder, 5 parts of carbomer, 200 parts of moisturizer；Wherein, mixture of the moisturizer for glycerine and lanolin, the glycerine Weight ratio with lanolin is 1.0~2.5：1.0~2.0；The preparation method is the same as that of Example 1.
Embodiment 3
A kind of antibacterial ointment of wound burn includes the component of following parts by weight：300 parts of tea-seed oil, 20 parts of Radix Angelicae Sinensis, beeswax 30 parts, 2 parts of red lead, 10 parts of blood tone tablet, 10 parts of the bletilla striata, 1 part of organic acid rare-earth salts, 5 parts of modified carbon nano-tube, nano oxidized silver powder 0.5 part, 20 parts of carbomer, 450 parts of moisturizer；Wherein, mixture of the moisturizer for glycerine and lanolin, the glycerine with The weight ratio of lanolin is 1.0~2.5：1.0~2.0；The preparation method is the same as that of Example 1.
Above-mentioned wound burns antibacterial ointment available for treating outside the various skins such as burn and scald, frostbite, insect-animal injury, traumatic injury Wound, suitable for man, female, old, children.
Application method：It after treatment of wounds is clean, is directly applied on wound, daily 1~2 time.
Taboo：During treatment, avoid and take ginger, white wine and shrimp.
Case 1：Mr. Wang, 5 years old, by charcoal fire wound, burn site played bleeding blister, and skin infection is suppurated, and treatment of wounds is clean Afterwards, above-mentioned traumatic is applied to wound, smeared 1~2 time daily, fully recovered after a week, the surface of a wound forms a scab and comes off after two weeks Afterwards, neoplastic skin it is smooth, it is flexible, without scar.
Case 2：Tan, man 22 years old, occur traffic accident and cause serious scratch, right anklebone on the way to office by motorcycle The dotted wound bleedings of 3cm are seen on folding, and complete dislocation, head, and right leg outer side is shown in 10 × 7cm wounds, and wound infection is suppurated, by wound After processing is clean, above-mentioned traumatic is applied to wound, is fully recovered after smearing 1~2 time, 10 days daily, surface of a wound knot after one month After scab comes off, neoplastic skin is smooth, it is flexible, without scar.
Case 3：Zhang, female, 53 years old, by fire wound wrist when cooking, by treatment of wounds it is clean after, above-mentioned traumatic is applied Be put on wound, fully recover after smearing 1~2 time, 8 days daily, after surface of a wound incrustation comes off after 15 days, neoplastic skin is smooth, it is flexible, Without scar.
It is that invention wound burn bacteriostatic and its processing method are expounded above, is used to help understand this hair It is bright, but embodiments of the present invention and be not restricted to the described embodiments, it is any without departing from the change made under the principle of the invention, Modification is substituted, combination, is simplified, and be should be equivalent substitute mode, is included in the interior of protection scope of the present invention.

Claims (9)

  1. The bacteriostatic 1. a kind of wound is burnt, it is characterised in that include the component of following parts by weight：50~300 parts of tea-seed oil, when Return 10~20 parts, 15~30 parts of beeswax, 1~2 part of red lead, 5~10 parts of blood tone tablet, 5~10 parts of the bletilla striata, organic acid rare-earth salts 0.5 ~1 part, 2~5 parts of modified carbon nano-tube, 0.2~0.5 part of nano oxidized silver powder.
  2. The bacteriostatic 2. wound according to claim 1 is burnt, it is characterised in that：150~200 parts of tea-seed oil, Radix Angelicae Sinensis 15~ 18 parts, 20~22 parts of beeswax, 1 part of red lead, 7~8 parts of blood tone tablet, 7~8 parts of the bletilla striata, 0.6 part of organic acid rare-earth salts, carbon modified receive 3~4 parts of mitron, 0.3 part of nano oxidized silver powder.
  3. The bacteriostatic 3. wound according to claim 1 is burnt, it is characterised in that：The organic acid rare-earth salts is formic acid One kind in cerium, cerous acetate, butyric acid cerium, valeric acid cerium, isooctyl acid cerium, maleic acid cerium, fumaric acid cerium, benzene sulfonic acid cerium and cerous tarate It is or a variety of.
  4. The bacteriostatic 4. wound according to claim 3 is burnt, it is characterised in that：The organic acid rare-earth salts by formic acid, Acetic acid, butyric acid, valeric acid, isooctyl acid, maleic acid, fumaric acid, benzene sulfonic acid or tartaric acid sodium salt react and be made with cerous nitrate.
  5. The bacteriostatic 5. wound according to claim 1 is burnt, it is characterised in that：The antibacterial medicines be gelling agent, the suppression What bacterium drug further included following weight parts prepares raw material：2~20 parts of carbomer, 200~450 parts of moisturizer；Wherein, the moisturizing The weight ratio of mixture of the agent for glycerine and lanolin, the glycerine and lanolin is 1.0~2.5：1.0~2.0.
  6. The bacteriostatic 6. wound according to claim 1 is burnt, it is characterised in that：The processing side of the modified carbon nano-tube Method includes the following steps：
    (1) by single-walled carbon nanotube powder in dense H2SO4With dense HNO3Nitration mixture in 60 DEG C acidification 1-4h, eccentric cleaning after reaction To neutrality；
    (2) single-walled carbon nanotube cleaned, thionyl chloride ultrasonic disperse 2~3 hours in enough absolute ethyl alcohols are acidified, so It is stirred to react at a temperature of 70 DEG C~100 DEG C 20~30 hours afterwards, vacuum distillation removes thionyl chloride, filters to obtain solid content steaming Distilled water is washed, and vacuum drying obtains acyl chlorides carbon nano tube；
    (3) by acyl chlorides carbon nano tube, sodium sulfanilate in enough absolute ethyl alcohols ultrasonic disperse 10~20 minutes, in 18~36 hours are stirred to react at 60 DEG C~80 DEG C, after reaction solution is cooled to room temperature, filter to obtain solid content distillation washing It washs, is dried in vacuo, obtains modified carbon nano-tube.
  7. 7. a kind of processing method of wound burn bacteriostatic, it is characterised in that prepared by following steps：
    (a) it is 10~20 parts of the Radix Angelicae Sinensis of parts by weight, 1~2 part of red lead, 5~10 parts of blood tone tablet, 5~10 parts of the bletilla striata, organic acid is dilute It is 20~80 that 0.5~1 part of earth salt, 2~5 parts of modified carbon nano-tube, 0.2~0.5 part of nano oxidized silver powder, which are added to parts by weight, In the organic solvent of part, 0.5-3h is stirred with the rate of 200-2000rpm in the ball mill at room temperature, forms mixed-powder；
    (b) mixed-powder and 15~30 parts of beeswax formed step (a) is added in 50~300 parts of tea-seed oil fully mixed It closes, ultrasonic disperse 2~3 hours, and with the rate stirring of 100-300rpm until being uniformly mixing to obtain final wound burn suppression Bacterium medicine.
  8. 8. processing method according to claim 7, it is characterised in that：The processing method of the modified carbon nano-tube, including Following steps：
    (1) by single-walled carbon nanotube powder in dense H2SO4With dense HNO3Nitration mixture in 60 DEG C acidification 1-4h, eccentric cleaning after reaction To neutrality；
    (2) single-walled carbon nanotube cleaned, thionyl chloride ultrasonic disperse 2~3 hours in enough absolute ethyl alcohols are acidified, so It is stirred to react at a temperature of 70 DEG C~100 DEG C 20~30 hours afterwards, vacuum distillation removes thionyl chloride, filters to obtain solid content steaming Distilled water is washed, and vacuum drying obtains acyl chlorides carbon nano tube；
    (3) by acyl chlorides carbon nano tube, sodium sulfanilate in enough absolute ethyl alcohols ultrasonic disperse 10~20 minutes, in 18~36 hours are stirred to react at 60 DEG C~80 DEG C, after reaction solution is cooled to room temperature, filter to obtain solid content distillation washing It washs, is dried in vacuo, obtains modified carbon nano-tube.
  9. 9. processing method according to claim 7, it is characterised in that：The organic solvent be containing carbon number be 2~10 it is low Grade alkylol.
CN201711496989.XA 2017-12-31 2017-12-31 Wound burn bacteriostatic and its processing method Pending CN108126109A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111493069A (en) * 2020-04-21 2020-08-07 桂方晋 Solid chlorine dioxide sustained release agent and preparation method thereof
CN112386663A (en) * 2020-12-08 2021-02-23 安徽草珊瑚生物科技有限公司 Preparation method of antibacterial lotion with long-acting antibacterial effect

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
崔建华: "《基础化学》", 31 August 2014 *
肖永庆: "《中华医学百科全书•中药炮制学》", 30 November 2016 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111493069A (en) * 2020-04-21 2020-08-07 桂方晋 Solid chlorine dioxide sustained release agent and preparation method thereof
CN112386663A (en) * 2020-12-08 2021-02-23 安徽草珊瑚生物科技有限公司 Preparation method of antibacterial lotion with long-acting antibacterial effect
CN112386663B (en) * 2020-12-08 2021-12-21 安徽草珊瑚生物科技有限公司 Preparation method of antibacterial lotion with long-acting antibacterial effect

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