CN108096507A - 一种治疗脑肿瘤及脑囊肿的中药组合物及制备方法 - Google Patents
一种治疗脑肿瘤及脑囊肿的中药组合物及制备方法 Download PDFInfo
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Abstract
本发明属于中药技术领域,提出以种治疗脑肿瘤及脑囊肿的中药组合物及制备方法。提出的一种治疗脑肿瘤及脑囊肿的中药组合物的原料组成及重量份为:干蟾皮3‑15份、山蛩3‑9份、蛴螬3‑9份、五朵云10‑15份、冰片20‑30份、川芎20‑30份、野桃枝15‑20份、人参15‑20份、天麻20‑30份、三七10‑15份、丹参15‑20份、大黄10‑20份、乳香8‑16份、三棱15‑20份、赤药9‑18份、牡丹皮10‑20份、半枝莲10‑20份、白芨8‑20份、甘草20‑30份。本发明中医中药治疗脑肿瘤、脑囊肿,无疑显著降低重疾对患者生理、生活、经济、精神等因素的影响,更进一步补充治疗脑肿瘤、囊肿的特效治疗手段,使患者整体生存、生命质量明显提高。
Description
技术领域
本发明属于中药技术领域,具体涉及一种治疗脑肿瘤及脑囊肿的中药组合物及制备方法。
背景技术
脑肿瘤(brain tumor)又称颅内肿瘤,是生在颅内的肿瘤,包括脑实质发生的原发性脑瘤和由身体其他部位转移颅内肿瘤既各种脑肿瘤,对神经系统有很大的危害;一般分为原发性和继发性两大类;原发性颅内肿瘤占中枢神经系统原发肿瘤的80-90%,椎管内肿瘤占10-20%,原发肿瘤来源于脑、脑膜、脑神经、血管、胚胎残余、垂体等。继发者有转移和侵入瘤;临床上主要表现为颅内增高症状、局限性症状、脑瘤定位部位与相关管理区的症状、精神症状、生命体征的症状等;虽神经外科治疗手段包括定位手段已经成熟,但治疗风险依旧持高不下,患者耐受低且复发率高,患者生存质量差,死亡率高。
脑囊肿(brain cyst)一般指蛛网膜囊肿,囊壁多为珠网膜、神经胶质和软脑膜。囊内为脑脊液样囊液,囊肿位于脑表面,不累及脑实质,体积大小与疾病严重程度成正比且患者多为儿童、老年(>65岁)。此疾多行神经外科开颅切除术,缺乏内服消除的中药,治疗风险大且易留下后遗症,对患者后期生存、生活造成一定影响。
祖国医学-传统中医认为脑肿瘤、脑囊肿为髓海病变。与脏腑清阳之气相关,主要与风、火、痰、湿、血瘀、气滞、互为作用,加之机体气滞血瘀,血行不畅,功能紊乱,痰湿淤滞,髓海受损,痰瘀凝聚,闭阻脉络,淤久化热,热灼津液,引动肝风,伤阴损阳所致。中医在治疗脑囊肿、脑肿瘤长处日显长处,对脑肿瘤外科手术后/放疗后的患者及其无法手术的患者均行中医治疗已取得明显疗效,甚至消除肿瘤。其中加减药方通过规范的治疗对颅内囊肿均有明显的消除作用。
发明内容
针对背景技术所存的问题,本发明的目的是提出不手术、不放疗、不化疗,也可取得明显治疗结果的一种治疗脑肿瘤及脑囊肿的中药组合物及制备方法。
本发明为完成上述目的采用如下技术方案:
一种治疗脑肿瘤及脑囊肿的中药组合物,所述中药组合物的原料组成及重量份为:干蟾皮3-15份、山蛩3-9份、蛴螬3-9份、五朵云10-15份、冰片20-30份、川芎20-30份、野桃枝15-20份、人参15-20份、天麻20-30份、三七10-15份、丹参15-20份、大黄10-20份、乳香8-16份、三棱15-20份、赤药9-18份、牡丹皮10-20份、半枝莲10-20份、白芨8-20份、甘草20-30份。
所述中药组合物的原料组成及重量份为:干蟾皮5-13份、山蛩5-7份、 蛴螬5-8份、五朵云12-13份、 冰片24-28份、川芎24-28份、野桃枝17-19份、人参17-19份、天麻24-28份、三七12-14份、丹参17-19份、大黄12-18份、乳香10-14份、三棱16-18份、赤药12-16份、牡丹皮14-18份、半枝莲14-18份、白芨14-18份、甘草24-28份。
所述中药组合物的原料组成及重量份为:干蟾皮10份 、山蛩8份、蛴螬8份、 五朵云13份、冰片25份 、 川芎25份、野桃枝18份、人参18份、天麻25份 、三七13份 、 丹参18份、大黄18份、乳香14份 、 三棱18份 、赤药15份 、 牡丹皮15份、 半枝莲15份、白芨15份、甘草25份。
所述的冰片选用合成龙脑,其特征为无色半透明或白色半透明松脆状晶体,具有挥发性,点燃发生浓烟,并有带光火焰;合成龙脑中龙脑不得少于55.0%、樟脑不得少于0.5%。
一种治疗脑肿瘤及脑囊肿的中药组合物的制备方法,所述的制备方法包括有内服大丸剂的制备和鼻腔给药浓缩剂的制备,其具体步骤如下:
(一)内服大丸剂的制备:
1)选干蟾皮3-15份酒制后包裹黄泥,放入火灰煨存,后研细备用;山蛩3-9份沙烫法,研细备用;蛴螬3-9份焙干研细备用;冰片20-30份研细备用;将五朵云10-15份、川芎20-30份、野桃枝15-20份、人参15-20份、天麻20-30份、三七10-15份、丹参15-20份、大黄10-20份、乳香8-16份、三棱15-20份、赤药9-18份、牡丹皮10-20份、半枝莲10-20份、白芨8-20份、甘草20-30份自然干燥或烘干以200目研细,诸药混用,后研磨为面粉样细粉;
2)步骤1)所得到的细粉以2-3cm厚度平铺于室温28℃,相对湿度68的室内,用黄酒均匀撒湿,药材浸润不沾手为宜,然后把将药材放入大丸机中,制出26mm大丸剂。
(二)鼻腔给药浓缩剂的制备:
1)选干蟾皮3-15份直接包裹黄泥,放入火灰煨存,后研细备用;选山蛩3-9份自然干燥,后研细备用;选蛴螬3-9份自然干燥,研细备用;后将三者粉末搅均,置入75%乙醇提取2-3次,提取时间为8小时,过滤浓缩后得到提取物备用;选冰片20-30份研粉置入乳钵中,少量多次加入95%乙醇,研磨直至全部溶解得到冰片溶解液,密封备用;
2)选五朵云10-15份、川芎20-30份、野桃枝15-20份、人参15-20份、天麻20-30份、三七10-15份、丹参15-20份、大黄10-20份、乳香8-16份、三棱15-20份、赤药9-18份、牡丹皮10-20份、半枝莲10-20份、甘草20-30份植入蒸锅蒸15分钟,后取出放入煎锅加水埋没药材3cm水量文火煎出100ml药液;再次取出药材加入埋没药材3cm水量,文火煎出50ml药液;两次煎取时间为3h,后得煎取液,在剪取液中加入步骤1)的提取物和冰片溶解液,均匀混合后静止直至乙醇自然挥发,混合液后密度为1.4,PH值以5.0左右,密封制成鼻腔给药浓缩剂。
方中君药干蟾皮、山蛰、蛴螬、川芎、天麻。干蟾皮性辛、温、有毒,抗毒解毒,清热利水,止痛醒脑,其下调癌细胞周期相关蛋白的表达,诱导人体肝癌细胞HepC2细胞组织于G2/M期,提高免疫功能,诱导癌细胞凋亡,抑制转移癌生长。山蛩味辛、温、有毒,破结解聚,解毒肿,明显引起癌细胞核裂解细胞崩解,明显抑制癌细胞有丝分裂,增强NK细胞活性和提高T淋巴细胞活性。蛴螬味咸、微温、有毒,明显改变肿瘤血流,使肿瘤血管明显收缩,减少甚至封闭肿瘤血供存环境使其营养匮乏,瘤体萎缩不再生长。川芎味辛性阳,上行头目,血中气药,气善走窜,无阴粘滞之态,虽入血份,除去一切风,调一切气,行气破结,散头脑之结,通头络之气。天麻性味甘平,辛、温平息肝风、行气散结,止痉止痛,具有镇静、抗炎、镇痛、抗惊厥、增强T细胞免疫功能提高免疫能力,抗衰老改善脑细胞功能。
方中臣药人参、三七、丹参、白芨、三棱、牡丹皮。人参味甘、微苦、性温平。大补、固脱、生津、安神、益智,调经养络、大补受损机体。人参具有多靶点机制,调动机体内因,动员神经保护机制,加强自身免疫,其Rb1、Rb2抑制肿瘤血管新生抗肿瘤。三七性甘、微苦、温,散瘀止血、消肿止痛,活血补血,消结散结。丹参味苦、微寒,活血祛瘀、痛经止痛、清心除烦、凉血消痈,保护心血管内皮细胞、神经保护作用保护脑内细胞、保护脑组织,减轻缺血引起脑水肿,其呋喃环、琨类抑制肿瘤细胞DNA合成,使其启动凋亡系统,杀死肿瘤细胞。白芨味苦、甘、涩,收敛止血、消肿生肌、利水行水,明显抑制肿瘤血管内皮生长因子与其受体结合。三棱味苦、平、破血行气、消肿止痛、活血化瘀。牡丹皮味苦、辛、清热凉血、活血化瘀、退虚退热,明显改善因肿瘤引起机体高热。
方中佐药野桃枝、五朵云、乳香、大黄、半枝莲。野桃枝归心、肝经,具有活血通络、解毒杀虫之功,能明显减轻山蛩对肝脏毒副作用,加快排泄。五朵云味微苦、利水排尿、解毒杀虫、能解干蟾皮在体内堆积之毒。乳香味辛、温,活血行气止痛,消肿生肌,缓解山蛩、蛴螬对心脏毒副作用,减轻胃肠负担。大黄性寒、味苦,利湿退黄、泄热通便、解毒消痈,利于内服丸剂吸收与排泄,减轻肿瘤患者肠道功能,配合君药,明显改善患者食欲从根本上增强患者体制,改善患者生活。半枝莲性凉、味辛、微苦,清热解毒、活血祛瘀、利尿消肿,其加快体液循环,增强肾小球滤过,护肝保肝,加快药物代谢排除,减少药物体内堆积。
方中使药冰片、甘草、赤药。冰片味辛、苦、微寒,清香萱散,开窍醒脑,非病理性开放血脑屏障,引众药上行穿透血脑屏障,直达脑肿瘤。赤药通经、通络。甘草清热解毒有和有缓。
方中君、臣、佐、使各司起用,相互作用,充分发挥冰片开窍之功,使干蟾皮、山蛩、蛴螬、川芎、天麻的独特作用彰显淋淋。又符合中药典用标准,以毒解毒,阴阳相合,扶正祛邪,平息肝风、行气破结、破血行血、活血祛瘀、止痛治痛、利水利尿、消肿去阙、散结生肌、抗毒解毒、明显抑制肿瘤细胞血管增生、收缩肿瘤血管、截断血供,明显抑制癌细胞转录复制,抑制癌细胞DNA合成,启动凋亡因子使癌细胞崩解。平肝风、去热邪、消痰浊、撤湿邪彻底清髓海之病邪。
本发明提出的一种治疗脑肿瘤及脑囊肿的中药组合物及制备方法,采用上述技术方案所制得的内服大丸剂和鼻腔给药浓缩剂;通过鼻腔给药的,药物借助鼻黏膜及神经根绕过血脑屏障,绕过肝脏首关消除,直接到达瘤体;而方中使药冰片非病理性开放血脑屏障,增加药物在颅内浓度,起到立竿见影效果。而服用干燥丸剂、鼻腔给药系统大大减少了对重病患者消化系统的刺激,减轻了肝肾负担,患者食欲增加从根本上提高机能。方中君臣佐使科学各司其职,方中冰片开放血脑屏障,干蟾皮、山蛩虫、蛴螬的加入,以毒解毒,以大热解大毒,抑制肿瘤转录生长、抑制转移,切断血供瘤体萎缩消失。增加机体免疫能力,抑制癌蛋白表达,减少复发。
需要说明的是:脑在解刨结构的特殊性及在生理上的重要性限制药物进入脑内,而血脑屏障(BBB)的存在使常规给药后脑内的药物浓度甚低;而通过鼻腔给药系统(NDDS)是指在鼻腔内使用,经鼻黏膜吸收进入中枢神经系统(CNS)并维持一定的浓度达到治疗中枢神经系统疾病的给药途径;祖国医学在《皇帝内经》载有“以草刺鼻,嚏而已”;《肘后备急方》记载“皂角、葱白、韭汁、雄黄等药物或塞或吹或滴鼻内治疗急症的方法;《本草纲目》曾用巴豆油纸沾,燃烟熏鼻治疗中风痰厥、气急、中毒等;现代研究人体鼻腔表面积为150平方厘米,溶剂约为15ML,鼻腔可分为鼻前庭、嗅觉区、呼吸区,其中呼吸区的粘膜下分布丰富毛细血管,是药物鼻腔吸收的主要途径之一,此途径可有效避免经肝首关消除;其次,嗅神经上皮是CNS与外界直接接触的唯一组织,鼻腔给药后药物分子滞留于嗅神经部位粘膜易被吸收进入脑脊液;
冰片在祖国医学属于醒脑开窍药,《寿域神方》治头脑疼痛,冰片一钱、川芎五分,燃之吸入痰出则愈;《本草纲目》“疗喉痹、脑通,通诸窍,散郁火”,具有“芳香走窜、开窍醒脑、醒脑护脑、引药上行”的特点;加之现代研究发现冰片对血脑屏障具有开放速度快、且非病理性开放且可逆性、冰片促进血脑屏障开放不会引起脑的病理损害的特点,在体内以原形从粪、尿排出,使整体疗效更加确切、见效更快、肿瘤病人更易耐受。
本发明中医中药治疗脑肿瘤、脑囊肿,无疑显著降低重疾对患者生理、生活、经济、精神等因素的影响,更进一步补充治疗脑肿瘤、囊肿的特效治疗手段,使患者整体生存、生命质量明显提高。
具体实施方式
结合具体实施方式对本发明进行清楚、完整的描述,显然描述的案例仅是本发明实施案例的一部分而非全部实施例。
实施例1:一种治疗脑肿瘤及脑囊肿的中药组合物的制备方法,具体步骤如下:
制脑肿瘤、脑囊肿内服大丸剂:
选干蟾皮3份酒制后包裹黄泥,放入火灰煨存,研细备用;山蛩3份沙烫法,研细备用;蛴螬3份焙干研细备用;冰片20份研细备用;将五朵云10份、川芎20份、野桃枝15份、人参15份、天麻20份、三七10份、丹参15份、大黄10份、乳香8份、三棱15份、赤药9份、牡丹皮10份、半枝莲10份、白芨8份、甘草20份自然干燥或烘干以200目研细,诸药混用,后在进一步研磨直到研磨为面粉样细粉;
将面样药粉以2-3cm厚度平铺于室温28℃,相对湿度68的室内,用黄酒(以衡水老白干67℃为例说明)均匀撒湿,以每1平方药粉,厚度2cm,为例,药材浸润为不沾手为宜,后把一平方药材放入HK-93B(大丸机)中,制出26mm(12g)大丸。
制脑肿瘤、脑囊肿外用鼻腔给药浓缩剂:
选干蟾皮15份直接包裹黄泥,放入火灰煨存,后研细备用;选山蛩9份自然干燥,后研细备用;选蛴螬9份自然干燥,研细备用;后将三者粉末搅均,置入75%乙醇提取2-3次,提取时间为8小时,提取液过滤浓缩后备用;选冰片30份研粉置入乳钵中,少量多次加入95%乙醇,研磨直至全部溶解,密封备用。
选五朵云15份、川芎30份、野桃枝20份、天麻30份、人参20份、三七15份、赤药18份、丹参20份、大黄20份、乳香16份、三棱20份、牡丹皮20份、半枝莲20份、甘草30份植入蒸锅蒸15分钟,后取出放入煎锅加水埋没药材3cm水量文火煎出100ml药液;再次取出药材加入埋没药材3cm水量,文火煎出50ml药液。两次煎取时间为3h,后得煎取液,常温下冷却至50℃;此时加入步骤一提取物包括溶解于95%的冰片溶解液,均匀混合后静止直至乙醇自然挥发,混合液后密度为1.4,PH值以5.0左右,密封制成滴鼻液。
实施例2:
步骤一:制脑肿瘤、脑囊肿内服大丸剂
选干蟾皮8份酒制后包裹黄泥,放入火灰煨存,研细备用;山蛩8份沙烫法,研细备用;蛴螬8份焙干研细备用;冰片25研细备用;将五朵云13份、川芎25份、野桃枝18份、人参18份、天麻25份、三七13份、丹参18份、大黄18份、乳香14份、三棱18份、赤药15份、牡丹皮15份、半枝莲15份、白芨15份、甘草25份自然干燥或烘干以200目研细,诸药混用,后研磨为面粉样细粉。
诸药混合后以2-3cm厚度平铺于室温28℃,相对湿度68的室内,用黄酒(以衡水老白干67℃为例说明)均匀撒湿,以每1平方药粉,厚度2cm,为例,药材浸润不沾手为宜,后把一平方药材放入HK-93B(大丸机)中,制出26mm(12g)大丸。
步骤二:制脑肿瘤、脑囊肿外用鼻腔给药浓缩剂:
选干蟾皮3份直接包裹黄泥,放入火灰煨存,后研细备用;选山蛩3份自然干燥,后研细备用;选蛴螬3份自然干燥,研细备用;后将三者粉末搅均,置入75%乙醇提取2-3次,提取时间为8小时,过滤浓缩后备用;选冰片20份研粉置入乳钵中,少量多次加入95%乙醇,研磨直至全部溶解,密封备用。
选五朵云10份、川芎20份、野桃枝15份、天麻20份、人参15份、三七10份、赤药9份、丹参15份、大黄10份、乳香8份、三棱15份、牡丹皮10份、半枝莲10份、甘草20份、植入蒸锅蒸15分钟,后取出放入煎锅加水埋没药材3cm水量文火煎出100ml药液;再次取出药材加入埋没药材3cm水量,文火煎出50ml药液。两次煎取时间为3h,后得煎取液,常温下冷却至50℃;此时加入步骤一提取物包括溶解于95%的冰片溶解液,均匀混合后静止直至乙醇自然挥发,混合液后密度为1.4,PH值以5.0左右,密封制成滴鼻液。
实施例3:步骤一:制脑肿瘤、脑囊肿内服大丸剂
选干蟾皮15份酒制后包裹黄泥,放入火灰煨存,研细备用;山蛩9份沙烫法,研细备用;蛴螬9份焙干研细备用;冰片30份研细备用;将五朵云15份、川芎30份、野桃枝20份、人参20份、天麻30份、三七15份、丹参20份、大黄20份、乳香16份、三棱20份、赤药18份、牡丹皮20份、半枝莲20份、白芨20份、甘草30份自然干燥或烘干以200目研细,诸药混用,后研磨为面粉样细粉。
诸药混合后以2-3cm厚度平铺于室温28℃,相对湿度68的室内,用黄酒(以衡水老白干67℃为例说明)均匀撒湿,以每1平方药粉,厚度2cm,为例,药材浸润不沾手为宜,后把一平方药材放入HK-93B(大丸机)中,制出26mm(12g)大丸。
步骤二:制脑肿瘤、脑囊肿外用鼻腔给药浓缩剂:
选干蟾皮10份直接包裹黄泥,放入火灰煨存,后研细备用;选山蛩8份自然干燥,后研细备用;选蛴螬8份自然干燥,研细备用;后将三者粉末搅均,置入75%乙醇提取2-3次,提取时间为8小时,过滤浓缩后备用;选冰片30份研粉置入乳钵中,少量多次加入95%乙醇,研磨直至全部溶解,密封备用。
选五朵云13份、川芎25份、野桃枝18份、天麻25份、人参18份、丹参18份、三七13份、大黄18份、赤药15份、乳香14份、三棱18份、牡丹皮15份、半枝莲15份、甘草25份植入蒸锅蒸15分钟,后取出放入煎锅加水埋没药材3cm水量文火煎出100ml药液;再次取出药材加入埋没药材3cm水量,文火煎出50ml药液。两次煎取时间为3h,后得煎取液,常温下冷却至50℃;此时加入步骤一提取物包括溶解于95%的冰片溶解液,均匀很合后静止直至乙醇自然挥发,混合液后密度为1.4,PH值以5.0左右,密封制成滴鼻液。
此时治疗脑肿瘤、脑囊肿内服丸剂和外用滴鼻液已完成。
典型病例:
王某,男,63岁,河南周口人;2007年9月13号初诊,头痛剧烈、呕吐、眼球突出,视物模糊,高血压;头MRI诊断为:左额颞新生物。给本发明内服丸剂配合鼻腔外用药,服用一周明显显效,遂继续服用五个月后,诉症状消失,随后自行检查MRI诊断无异常。
汴某,男,33岁,河南汝州人,2011年10月8日,在上班途中无明显诱因出现意识丧失、口唇发绀、全身抽搐,5分钟后自行缓解,随去检查确诊:幕上脑胶质瘤。WHOI3~4级,行外科手术切除放疗治疗,后复发,患者拒绝外科手术治疗,单采取化疗保守治疗。随后收入我处后停止化疗,行本发明中医内服丸剂配合外用鼻腔给药,治疗一月后患者体重上升,精神状态良好,无复发相关病症,随后治疗五个月,患者拍片复查已无病灶。嘱咐巩固治疗一年,随访至今无复发。
李某某,女,78岁。山东人。2003年8月29日。向我处求助,主诉头疼、头晕、眼胀、肢体乏力对称,心情抑郁。其阴雨天明显,高血压、高血脂病史,既往体检有米粒样囊肿,现体检囊肿以发展为花生大小压迫脑组织。随后行本发明中医内服丸剂外用鼻腔给药,治疗6月以无明显体征,随后自行检查已经无囊肿。
Claims (5)
1.一种治疗脑肿瘤及脑囊肿的中药组合物,其特征在于:所述中药组合物的原料组成及重量份为:干蟾皮3-15份、山蛩3-9份、蛴螬3-9份、五朵云10-15份、冰片20-30份、川芎20-30份、野桃枝15-20份、人参15-20份、天麻20-30份、三七10-15份、丹参15-20份、大黄10-20份、乳香8-16份、三棱15-20份、赤药9-18份、牡丹皮10-20份、半枝莲10-20份、白芨8-20份、甘草20-30份。
2.根据权利要求1所述的一种治疗脑肿瘤及脑囊肿的中药组合物,其特征在于:所述中药组合物的原料组成及重量份为:干蟾皮5-13份、山蛩5-7份、 蛴螬5-8份、五朵云12-13份、冰片24-28份、川芎24-28份、野桃枝17-19份、人参17-19份、天麻24-28份、三七12-14份、丹参17-19份、大黄12-18份、乳香10-14份、三棱16-18份、赤药12-16份、牡丹皮14-18份、半枝莲14-18份、白芨14-18份、甘草24-28份。
3.根据权利要求1所述的一种治疗脑肿瘤及脑囊肿的中药组合物,其特征在于:所述中药组合物的原料组成及重量份为:干蟾皮10份 、山蛩8份、蛴螬8份、 五朵云13份、冰片25份、 川芎25份、野桃枝18份、人参18份、天麻25份 、三七13份 、 丹参18份、大黄18份、乳香14份 、 三棱18份 、赤药15份 、 牡丹皮15份、 半枝莲15份、白芨15份、甘草25份。
4.根据权利要求1所述的一种治疗脑肿瘤及脑囊肿的中药组合物,其特征在于:所述的冰片选用合成龙脑,其特征为无色半透明或白色半透明松脆状晶体,具有挥发性,点燃发生浓烟,并有带光火焰;合成龙脑中龙脑不得少于55.0%、樟脑不得少于0.5%。
5.制备权利要求1一种治疗脑肿瘤及脑囊肿的中药组合物的制备方法,所述的制备方法包括有内服大丸剂的制备和鼻腔给药浓缩剂的制备,其具体步骤如下:a)内服大丸剂的制备:1)选干蟾皮3-15份酒制后包裹黄泥,放入火灰煨存,后研细备用;山蛩3-9份沙烫法,研细备用;蛴螬3-9份焙干研细备用;冰片20-30份研细备用;将五朵云10-15份、川芎20-30份、野桃枝15-20份、人参15-20份、天麻20-30份、三七10-15份、丹参15-20份、大黄10-20份、乳香8-16份、三棱15-20份、赤药9-18份、牡丹皮10-20份、半枝莲10-20份、白芨8-20份、甘草20-30份自然干燥或烘干以200目研细,诸药混用,后研磨为面粉样细粉;2)步骤1所得到的细粉以2-3cm厚度平铺于室温28℃,相对湿度68的室内,用黄酒均匀撒湿,药材浸润不沾手为宜,然后把将药材放入大丸机中,制出26mm大丸剂;b)鼻腔给药浓缩剂的制备:1)选干蟾皮3-15份直接包裹黄泥,放入火灰煨存,后研细备用;选山蛩3-9份自然干燥,后研细备用;选蛴螬3-9份自然干燥,研细备用;后将三者粉末搅均,置入75%乙醇提取2-3次,提取时间为8小时,过滤浓缩后得到提取物备用;选冰片20-30份研粉置入乳钵中,少量多次加入95%乙醇,研磨直至全部溶解得到冰片溶解液,密封备用;2)选五朵云10-15份、川芎20-30份、野桃枝15-20份、人参15-20份、天麻20-30份、三七10-15份、丹参15-20份、大黄10-20份、乳香8-16份、三棱15-20份、赤药9-18份、牡丹皮10-20份、半枝莲10-20份、甘草20-30份植入蒸锅蒸15分钟,后取出放入煎锅加水埋没药材3cm水量文火煎出100ml药液;再次取出药材加入埋没药材3cm水量,文火煎出50ml药液;两次煎取时间为3h,后得煎取液,在剪取液中加入步骤1)的提取物和冰片溶解液,均匀混合后静止直至乙醇自然挥发,混合液后密度为1.4,PH值以5.0左右,密封制成鼻腔给药浓缩剂。
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