CN108096073B - Production process and application of traditional Chinese medicine oil prepared from Umbelliferae medicinal materials of Umbelliferae - Google Patents
Production process and application of traditional Chinese medicine oil prepared from Umbelliferae medicinal materials of Umbelliferae Download PDFInfo
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention relates to a production process for preparing traditional Chinese medicine oil by using Umbelliferae medicinal materials of Umbelliferae, which comprises the following steps: selecting raw materials of Umbelliferae plant medicinal materials of Umbelliferae, cleaning the medicinal materials, drying, crushing the plant raw materials into powder by using a crusher, and sieving the powder by using a 30-40-mesh sieve for later use; soaking before extraction, putting the powdery raw materials into a container, adding an extracting agent for soaking, wherein the ratio of the materials to the liquid is 1: 1-50; filling and sealing; fourthly, ultrahigh-pressure wall breaking treatment, namely putting the extraction container filled with the plant raw materials into an ultrahigh-pressure pressurizing cabin, starting equipment, treating the plant raw materials at the pressure of 50-800MPa for 1-60min, and performing cyclic treatment for 2-3 times; carrying out heat preservation treatment; sixthly, filtering. After the treatment by the treatment process, the theoretical leaching rate can reach 85.9 +/-1.6 percent, which is equivalent to about 3 weeks of common soaking, and the production period is greatly shortened.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a method for quickly and efficiently preparing traditional Chinese medicine oil and application of the method in the field of cosmetics.
Background
The active ingredients in the traditional Chinese medicinal materials can be divided into water-soluble active ingredients and fat-soluble active ingredients according to different solubilities of the traditional Chinese medicinal materials, and the active ingredients generally have important physiological and pharmacological effects and can help a human body to prevent and treat various diseases.
The rhizome of Umbelliferae plant of Umbelliferae can be used as medicine, and common medicinal materials such as radix Angelicae sinensis, radix Angelicae Dahuricae, and radix Angelicae Pubescentis; rhizoma Ligustici Chuanxiong and rhizoma Ligustici of Ligusticum genus. The liposoluble components in the Chinese medicinal materials have important physiological activity, such as ligustilide contained in radix Angelicae sinensis and rhizoma Ligustici Chuanxiong, and have effects of relieving asthma, tranquilizing, improving microcirculation, relaxing smooth muscle, inhibiting bacteria, and improving organism immunoregulation function. Meanwhile, the Umbelliferae plants also contain other active ingredients, such as aromatic acid substances, which also have important physiological activity.
Common methods for extracting the fat-soluble components of the traditional Chinese medicinal materials comprise a common soaking method, a steam distillation method, a chemical solvent extraction method, a supercritical carbon dioxide extraction method and the like. Steam distillation is an extraction method in which a plant material containing volatile components is co-distilled with water to distill off the volatile components along with the steam, and the volatile components are separated by condensation. Due to the over-high temperature during steam distillation, the heat-sensitive active ingredients in the medicinal materials may be decomposed, oxidized and the like, so that the content of the active ingredients is lost.
Supercritical CO2Although the extraction method can avoid the problems of decomposition, oxidation and the like of heat-sensitive substances when extracting the active ingredients of the traditional Chinese medicinal materials, the fluid is greatly lost after passing through a longer circulation line and a separation kettle in the extraction process, so the oil yield is not very high. Meanwhile, the method has high technical requirements and large equipment cost and investment. Especially, the requirement on the air tightness of the equipment is high, disastrous explosion accidents are easily caused, potential safety hazards exist, the utilization rate of the equipment on energy is low, and the energy consumption is high.
The traditional Chinese medicine oil is prepared by using a common soaking method, the production period is long, the time of several months is usually needed, and the production efficiency is low. Meanwhile, the longer production period is easy to cause the extraction medium to be oxidized and deteriorated, the rancidity is generated, and the product quality is influenced.
The research of the ultra-high pressure technology started in 1914, and the technology is mainly applied to the food industry at home and abroad, aiming at preventing the microbial pollution of food and prolonging the storage time of the food. Ultra-high-pressure extraction (UHPE), also called ultra-high cold isostatic pressure extraction, is that a hydrostatic pressure of 100 and 1000MPa is applied to a mixed solution of an extraction solvent and an extracted substance at normal temperature, and is kept for a period of time under a preset pressure, so that the pressure inside and outside a plant cell is quickly relieved after the pressure inside and outside the plant cell is balanced, and the effective components inside the cell can pass through the cell membrane and are transferred to an extraction medium outside the cell due to the sudden increase of the osmotic pressure inside and outside the cell and the structural change of the cell membrane, thereby achieving the purpose of extracting the effective components in the plant.
Compared with other traditional Chinese medicine oil preparation methods, the traditional Chinese medicine oil prepared by the ultrahigh pressure method has the following characteristics: 1. the extraction efficiency is high. Because of the higher pressure, the solvent can permeate into the cells in a very short time, so that the effective components quickly reach the dissolving balance. 2. Retaining the active components of the extract. Although the pressure is increased, the substance emits heat to the outside, and the high-pressure container and the external environment have good heat exchange, so that the whole extraction process can be basically carried out at room temperature, active substances in the medicinal materials can be retained to the maximum extent, and the problems of active ingredient denaturation, loss, pharmacological activity reduction and the like caused by heat are avoided. 3. Low energy consumption, safetyThe comprehensiveness is high. The deformation of fluid is less in the ultrahigh pressure extraction process, the energy consumption is less when the fluid is compressed, and no energy is consumed and transmitted in the pressure maintaining and releasing processes. The fluid has smaller compression ratio, and cannot generate increased volume change in the operation process, so that the risk of the device caused by the sealing property of the device is greatly reduced. Therefore, the safety of the ultrahigh pressure extraction equipment is far higher than that of the supercritical CO2And (4) extraction equipment.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a production process and application of traditional Chinese medicine oil prepared from umbelliferae medicinal materials in Umbelliferae, wherein the production process has short extraction time, low energy consumption and high extraction rate of effective components.
The technical scheme for realizing the purpose of the invention is as follows:
a production process for preparing Chinese medicinal oil from Umbelliferae medicinal materials of Umbelliferae comprises the following steps:
pretreatment of raw materials
Selecting raw materials of Umbelliferae plant of Umbelliferae, cleaning, oven drying, pulverizing into powder with a pulverizer, and sieving with 30-40 mesh sieve;
soaking before extraction
Putting the powdery raw materials into a container, adding an extracting agent for soaking, fully stirring, and soaking for 1-48h to fully soak the raw materials; the ratio of the material to the liquid is 1: 1-50;
the extractant is caprylic capric triglyceride: lauryl lactate ═ 1: 0.1 to 5;
filling and sealing the product
Filling the fully soaked raw materials into an extraction container, discharging air in the extraction container, and sealing;
four superhigh pressure broken wall is handled
Placing the extraction container containing plant material into an ultrahigh pressure pressurizing chamber, starting the equipment, treating at 50-800MPa for 1-60min, and circularly treating for 2-3 times;
heat preservation treatment
After ultrahigh pressure treatment, placing the extraction container in a constant temperature environment of 30-80 ℃, preserving heat for 24-72h, and simultaneously carrying out ultrasonic treatment every 4-6 h, wherein the treatment time is 10min each time and the power is 300 w;
sixthly, filtering the processed feed liquid to obtain traditional Chinese medicine oil.
Moreover, the feed-liquid ratio is 1: 1-4.
And the pressure maintaining time of the ultrahigh pressure wall breaking treatment is 15-30 min.
Moreover, the heat preservation treatment temperature is 40-50 ℃.
The invention has the advantages and positive effects that:
1. the production period is shortened. The angelica oil (material-liquid ratio is 1:1) which is normally soaked for 6 weeks is taken as the theoretical leaching rate of 100 percent, and after materials with the same material-liquid ratio are treated by the treatment process, the theoretical leaching rate can reach 85.9 +/-1.6 percent, which is equivalent to the normal soaking for about 3 weeks, thereby greatly shortening the production period.
Content and extraction rate of ligustilide in angelica oil prepared by common soaking method
2. The invention has various advantages by adopting the ultrahigh pressure extraction technology, including short extraction time, low energy consumption, high extraction rate of effective components, capability of avoiding inactivation and loss of the effective components caused by heat effect, and the like. Simple operation and is suitable for industrial production.
3. The invention adopts the extracted finished product, and the detection shows that the loss of active ingredients is less, and the product quality is stable and controllable.
Detailed Description
The process of the invention is described below by means of specific embodiments. Unless otherwise specified, the technical means used in the present invention are well known to those skilled in the art. In addition, the embodiments should be considered illustrative, and not restrictive, of the scope of the invention, which is defined solely by the claims. It will be apparent to those skilled in the art that various changes or modifications in the components and amounts of the materials used in these embodiments can be made without departing from the spirit and scope of the invention.
The invention provides a production process for preparing traditional Chinese medicine oil by using Umbelliferae medicinal materials of Umbelliferae, which specifically comprises the following steps:
1. pretreatment of raw materials
Selecting raw materials of Umbelliferae plants of Umbelliferae, and pretreating. Cleaning the medicinal materials, oven drying, pulverizing into powder with a pulverizer, and sieving with 40 mesh sieve.
2. Soaking before extraction
Putting powdery raw materials into a container, adding an extracting agent (the extracting agent is various oils and fats permitted in the cosmetic used raw material list, such as caprylic/capric triglyceride and lauryl lactate, and the extracting agent is caprylic/capric triglyceride and lauryl lactate in a ratio of 1: 0.1-5), soaking at a ratio of 1:1-1:50, preferably 1:1-1:10, more preferably 1:1-1:4, stirring thoroughly, soaking for 1-48h (preferably 6-8h), and making the raw materials thoroughly soaked.
3. Filling and sealing
Placing the soaked materials into an extraction container, discharging air, and sealing.
4. Ultrahigh pressure wall breaking treatment
Placing the container containing plant material into an ultrahigh pressure pressurizing chamber, starting the equipment, treating at 50-800MPa for 1-60min, preferably 15-30min, and circulating for 2-3 times.
5. Heat preservation treatment
After the ultrahigh pressure treatment, the extraction container is placed in a constant temperature environment (30-80 deg.C), preferably 40-50 deg.C, above room temperature to avoid the damage of excessive temperature to the leached effective components and avoid the oxidation of the extractant, and the temperature is maintained for 24-72 h. Meanwhile, ultrasonic treatment is carried out every 4-6 hours (each treatment time is 10min, and the power is 300 w). The lipid-soluble components in the medicinal materials are further leached out by the wall breaking effect of the ultrahigh pressure on the medicinal material cells and an ultrasonic auxiliary method. The content of effective components of the medicinal oil obtained by the treatment can reach the effect of common soaking for 3-4 weeks. Shortens the production period of medicinal oil.
6. Filtration
Filtering the treated liquid to obtain the traditional Chinese medicine oil.
7. Measurement of ligustilide content
1. Measurement of ligustilide standard curve
Taking 100 mu L ligustilide standard sample, and diluting chloroform to 100mL as stock solution for later use. For measurement of the standard curve, 50, 100, 150, 200, 250, and 300. mu.L of the solution was transferred from the stock solution, and the volume was adjusted to 10mL using chloroform, and the absorbance was measured at a wavelength of 318nm to prepare a standard curve.
2. Determination of ligustilide content in sample
The sample is weighed to 50mg, the volume is adjusted to 10mL by using chloroform, and an extraction medium is used as a blank control sample. The absorbance of the sample was measured at 318nm and 3 times of the measurement were carried out in parallel. And calculating the content of ligustilide in the sample.
8. Determination of content of phenolic acid substances
Accurately weighing 20g of sample, placing the sample in a conical flask with a plug, adding 50mL of n-hexane, fully shaking for 3min, adding 20mL of 60% methanol, fully shaking for 5min, standing the sample in a 125mL separating funnel for 20min, separating the liquid, adding 20mL of 60% methanol into the upper layer liquid, re-extracting for 1 time, combining the two lower layer filtrates, concentrating the combined lower layer filtrate in a rotary evaporator, adding methanol to the mixture to obtain a test solution, and thus obtaining the test solution. The test solution was passed through a 0.45 μm microporous filter and analyzed by HPLC. Shimadzu LC-20AT, column: c18Reversed phase column, 4.6 x 250mm, 5.0 μm, diode array DAD detector.
Chromatographic conditions are as follows: mobile phase: acetonitrile-0.085% phosphoric acid solution (17:83), column temperature 35 ℃, wavelength 316 nm.
The following is an implementation mode for preparing the traditional Chinese medicine oil according to different proportions of extracting solutions and different extraction conditions, and also comprises content detection of ligustilide and phenolic acid substances (ferulic acid), and the specific content is as follows:
example 1:
preparing angelica oil: caprylic acid/capric acid triglyceride is used as an extracting agent, the material ratio is 1:1, the ultrahigh pressure condition is 400MPa, the pressure maintaining time is 20min, the heat preservation treatment is carried out for 48h at 40 ℃, ultrasonic treatment is carried out once every 6h in the period, each treatment is carried out for 10min, and the product is obtained by filtration, wherein the content of ligustilide is 8.85mg/g, and the content of ferulic acid is 0.12 mu g/g.
Example 2:
preparing angelica oil: lauryl lactate is used as an extracting agent, the material ratio is 1:1, the ultrahigh pressure condition is 400MPa, the pressure maintaining time is 20min, the heat preservation treatment is carried out for 48h at 40 ℃, ultrasonic treatment is carried out once every 6h in the period, each time is 10min, and the product GB2 is obtained by filtration, wherein the content of ligustilide is 8.90mg/g, and the content of ferulic acid is 30.1 mu g/g.
Component analysis shows that when the lauryl lactate is used as an extractant, the product contains aromatic acids (ferulic acid, caffeic acid and the like) with the total content of 1-500 mu g/g, and the content of the aromatic acids is obviously improved compared with that when caprylic/capric triglyceride is used as the extractant (the content of the aromatic acids is less than 1 mu g/g), which indicates that the extraction medium is more effective for extracting the aromatic acids than caprylic/capric triglyceride. Lauryl lactate, as a derivative of lactic acid, produces lactic acid during use through the action of enzymes in the skin. When the lauryl lactate is used for preparing the resident beauty skin care product, the concentration of the resident beauty skin care product is not too high, otherwise, excessive lactic acid is generated possibly, certain irritation is generated to the skin, and the skin allergy risk is improved. The caprylic/capric triglyceride is widely applied to the industries of food, medicine, cosmetics and the like and has been proved to have no irritation to human bodies. The mixed system of caprylic/capric triglyceride and lauryl lactate is used as an extracting agent, so that the content of aromatic acid substances in the product can be increased, the product is endowed with the effects of oxidation resistance, aging resistance and the like, meanwhile, the leaching efficiency of fat-soluble components can be ensured, the irritation of the product to the skin in the use process is reduced, and the skin allergy risk is avoided.
Example 3:
preparing angelica oil: using caprylic/capric triglyceride and lauryl lactate mixed oil (1:1) as an extracting agent, with a material ratio of 1:1, under the condition of 200MPa of ultrahigh pressure and a pressure maintaining time of 20min, and filtering to obtain the product, wherein the content of ligustilide is 5.58mg/g, and the content of ferulic acid is 12.6 mu g/g.
Example 4:
preparing angelica oil: using caprylic acid/capric acid triglyceride and lauryl lactate mixed oil (1:1) as an extracting agent, with a material ratio of 1:1, under the condition of ultrahigh pressure of 300MPa, maintaining the pressure for 20min, and filtering to obtain the product, wherein the content of ligustilide is 5.80mg/g, and the content of ferulic acid is 13.1 μ g/g.
Example 5:
preparing angelica oil: using caprylic acid/capric acid triglyceride and lauryl lactate mixed oil (1:1) as an extracting agent, with a material ratio of 1:1, under the condition of ultrahigh pressure of 400MPa, keeping the pressure for 20min, and filtering to obtain the product, wherein the content of ligustilide is 5.92mg/g, and the content of ferulic acid is 13.2 mug/g.
Example 6:
preparing angelica oil: using caprylic/capric triglyceride and lauryl lactate mixed oil (1:1) as an extracting agent, with a material ratio of 1:1, under the condition of ultrahigh pressure of 400MPa, keeping the pressure for 15min, and filtering to obtain the product, wherein the content of ligustilide is 5.85mg/g, and the content of ferulic acid is 13.1 μ g/g.
Example 7:
preparing angelica oil: using caprylic acid/capric acid triglyceride and lauryl lactate mixed oil (1:1) as an extracting agent, with a material ratio of 1:1, under the condition of ultrahigh pressure of 400MPa, keeping the pressure for 25min, and filtering to obtain the product, wherein the content of ligustilide is 5.88mg/g, and the content of ferulic acid is 13.2 mug/g.
The experimental result shows that the extraction pressure and the pressure maintaining time have great influence on the content of ligustilide in the angelica oil. Taking ligustilide content in samples prepared by different extraction processes as evaluation index, examining extraction pressure and extraction time, and determining extraction pressure of 400MPa and extraction time of 20 min.
Example 8:
preparing angelica oil: caprylic acid/capric acid triglyceride and lauryl alcohol lactate mixed grease (1:4) are used as an extracting agent, the material ratio is 1:1, the ultrahigh pressure condition is 400MPa, the pressure maintaining time is 20min, the heat preservation treatment is carried out for 48h at 40 ℃, the ultrasonic treatment is carried out once every 6h during the period, the product is obtained by filtering each treatment for 10min, the ligustilide content is 8.86mg/g, and the ferulic acid content is 22.9 mug/g.
Example 9:
preparing angelica oil: the preparation method comprises the steps of using caprylic/capric triglyceride and lauryl lactate mixed grease (1:1) as an extracting agent, performing material ratio of 1:1, performing heat preservation treatment at 40 ℃ for 48h under the condition of ultrahigh pressure of 400MPa, keeping pressure for 20min, performing ultrasonic treatment once every 6h for 10min, and filtering to obtain the product, wherein the content of ligustilide is 8.83mg/g, and the content of ferulic acid is 15.0 mu g/g.
Example 10:
preparation of ligusticum oil: using caprylic/capric triglyceride as extractant, with a material ratio of 1:1, under ultrahigh pressure condition of 400MPa, holding pressure for 20min, standing at 40 deg.C for 48h, performing ultrasonic treatment every 6h for 10min, and filtering to obtain product with ligustilide content of 9.8mg/g and ferulic acid content of 0.12 μ g/g
Example 11:
preparation of ligusticum oil: lauryl lactate is used as an extracting agent, the material ratio is 1:1, the ultrahigh pressure condition is 400MPa, the pressure maintaining time is 20min, the mixture is placed at 40 ℃ for 48h, ultrasonic treatment is carried out once every 6h in the period, each time is 10min, and the product is obtained by filtration, wherein the content of ligustilide is 9.85mg/g, and the content of ferulic acid is 33.1 mu g/g.
Example 12:
preparation of ligusticum oil: caprylic/capric triglyceride and lauryl lactate mixed oil (1:1) are used as an extracting agent, the material ratio is 1:1, the ultrahigh pressure condition is 400MPa, the pressure maintaining time is 20min, the mixture is placed at 40 ℃ for 48h, ultrasonic treatment is carried out once every 6h during the period, the nursing time is 10min each time, and the product is obtained by filtration, wherein the content of ligustilide is 9.78mg/g, and the content of ferulic acid is 15.6 mu g/g.
Example 13:
preparation of ligusticum oil: the preparation method comprises the steps of using caprylic/capric triglyceride and lauryl lactate mixed oil (1:2) as an extracting agent, keeping the material ratio at 1:1 under the condition of ultrahigh pressure of 400MPa for 20min, standing at 40 ℃ for 48h, carrying out ultrasonic treatment once every 6h for 10min each time, and filtering to obtain the product, wherein the content of ligustilide is 9.81mg/g, and the content of ferulic acid is 18.2 mu g/g.
Example 14:
preparation of ligusticum oil: the preparation method comprises the steps of using caprylic/capric triglyceride and lauryl lactate mixed oil (1:3) as an extracting agent, keeping the material ratio at 1:1 under the condition of ultrahigh pressure of 400MPa for 20min, standing at 40 ℃ for 48h, carrying out ultrasonic treatment once every 6h for 10min each time, and filtering to obtain the product, wherein the content of ligustilide is 9.86mg/g, and the content of ferulic acid is 22.4 mu g/g.
Example 15:
preparation of ligusticum wallichii oil: caprylic acid/capric acid triglyceride is used as an extracting agent, the material ratio is 1:1, the ultrahigh pressure condition is 400MPa, the pressure maintaining time is 20min, the mixture is placed at 40 ℃ for 48h, ultrasonic treatment is carried out once every 6h in the period, each treatment time is 10min, and the product is obtained by filtration, wherein the content of ligustilide is 8.23mg/g, and the content of ferulic acid is 0.4 mu g/g.
Example 16:
preparation of ligusticum wallichii oil: lauryl lactate is used as an extracting agent, the material ratio is 1:1, the ultrahigh pressure condition is 400MPa, the pressure maintaining time is 20min, the mixture is placed at 40 ℃ for 48h, ultrasonic treatment is carried out once every 6h in the period, each treatment time is 10min, and the product is obtained by filtration, wherein the content of ligustilide is 8.19mg/g, and the content of ferulic acid is 42.9 mu g/g.
Example 17:
preparation of ligusticum wallichii oil: the preparation method comprises the steps of using caprylic/capric triglyceride and lauryl lactate mixed oil (1:1) as an extracting agent, keeping the material ratio at 1:1 under the condition of ultrahigh pressure of 400MPa for 20min, standing at 40 ℃ for 48h, carrying out ultrasonic treatment once every 6h for 10min each time, and filtering to obtain the product, wherein the content of ligustilide is 8.20mg/g, and the content of ferulic acid is 20.2 mu g/g.
Example 18:
preparation of ligusticum wallichii oil: caprylic acid/capric acid triglyceride and lauryl alcohol lactate mixed grease (1:0.5) are used as an extracting agent, the material ratio is 1:1, the ultrahigh pressure condition is 400MPa, the pressure maintaining time is 20min, the mixture is placed at 40 ℃ for 48h, ultrasonic treatment is carried out once every 6h in the period, each ultrasonic treatment is carried out for 10min, and the product is obtained by filtration, wherein the content of ligustilide is 8.20mg/g, and the content of ferulic acid is 11.2 mu g/g.
Example 19:
preparation of ligusticum wallichii oil: the caprylic/capric triglyceride and lauryl lactate mixed grease (1:4) are used as an extracting agent, the material ratio is 1:1, the ultrahigh pressure condition is 400MPa, the pressure maintaining time is 20min, the mixture is placed at 40 ℃ for 48h, ultrasonic treatment is carried out once every 6h during the period, each time is 10min, and the product is obtained by filtration, wherein the content of ligustilide is 8.25mg/g, and the content of ferulic acid is 30.4 mu g/g.
The wall breaking effect of the ultrahigh pressure on plant cells enables active ingredients in the medicinal materials to be more easily brought out by an extracting agent, and the extraction efficiency of the ligustilide can be greatly improved in a short time by auxiliary methods such as heat preservation, ultrasound and the like.
According to the invention, caprylic/capric triglyceride and lauryl lactate mixed grease are used as extraction media, so that the problem of solvent residue possibly caused by using a traditional organic solvent to extract the substances is avoided, the safety of the product applied to the daily chemical industry is improved, and the leaching efficiency of effective components in plants can be ensured.
Claims (1)
1. A method for preparing traditional Chinese medicine oil by using Umbelliferae medicinal materials of Umbelliferae is characterized by comprising the following steps: the method comprises the following steps of crushing the plant medicinal material raw materials, soaking the crushed raw materials by an extracting agent, and adopting an ultrahigh pressure wall breaking technology to strengthen the extraction process:
pretreatment of raw materials
Selecting raw materials of Umbelliferae plant of Umbelliferae, cleaning, oven drying, pulverizing into powder with a pulverizer, and sieving with 30-40 mesh sieve;
soaking before extraction
Putting the powdery raw materials into a container, adding an extracting agent for soaking, fully stirring, and soaking for 1-48h to fully soak the raw materials; the ratio of material to liquid is 1: 1;
the extracting agent is 1: 1-3 caprylic/capric triglyceride: lauryl alcohol lactate;
filling and sealing the product
Filling the fully soaked raw materials into an extraction container, discharging air in the extraction container, and sealing;
four superhigh pressure broken wall is handled
Placing the extraction container containing plant material into an ultrahigh pressure pressurizing chamber, starting the equipment, treating at 50-800MPa for 15-30min, and circularly treating for 2-3 times;
heat preservation treatment
After ultrahigh pressure treatment, placing the extraction container in a constant temperature environment of 40-50 ℃, preserving heat for 24-72h, and simultaneously carrying out ultrasonic treatment every 4-6 h, wherein the treatment time is 10min each time and the power is 300 w;
sixthly, filtering the processed feed liquid to obtain traditional Chinese medicine oil;
the Umbelliferae medicinal material of Umbelliferae is rhizoma Ligustici.
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| CN110200855A (en) * | 2019-05-31 | 2019-09-06 | 北京昱美源科贸有限公司 | The production technology of Chinese medicine medicine oil is prepared with antioxidation medicinal material |
| CN110123676A (en) * | 2019-05-31 | 2019-08-16 | 北京昱美源科贸有限公司 | It is a kind of to utilize the production technology that there is anti-inflammatory effect medicinal material of releiving to prepare Chinese medicine medicine oil |
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