CN108095886A - A kind of contact lenses for being used to treat glaucoma - Google Patents
A kind of contact lenses for being used to treat glaucoma Download PDFInfo
- Publication number
- CN108095886A CN108095886A CN201711291361.6A CN201711291361A CN108095886A CN 108095886 A CN108095886 A CN 108095886A CN 201711291361 A CN201711291361 A CN 201711291361A CN 108095886 A CN108095886 A CN 108095886A
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- China
- Prior art keywords
- glaucoma
- layer
- contact lenses
- contact lens
- hollow cavity
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
Abstract
The invention discloses a kind of for treating the contact lenses of glaucoma, its entirety is rendered as the contact lens (1) of spherical crown shape, mainly it is prepared by soft layer (8) and hard layer (7) two parts by plane bonding technique with hot press forming technology, wherein soft layer (8) is located at the internal layer of the contact lens (1), and hard layer (7) is then located at the outer layer of the contact lens (1)；Microfluidic channel (3) and hollow cavity (4) are also formed in the inside of contact lens (1)；Wherein, hollow cavity (4) is used to store liquid medicine (5)；Microfluidic channel (3) is used to convey liquid medicine (5).The present invention is improved by the material to contact lenses and eyeglass internal structure and corresponding technique, using contact lenses as drug delivery system, administration is triggered with the abnormal intraocular pressure of glaucoma patient, it can be administered continuously according to liquid microcavity in intraocular pressure rise extruding soft layer, bioavilability is high.
Description
Technical field
The invention belongs to the field of medical instrument technology, more particularly, to a kind of for treating the contact lenses of glaucoma,
The contact lenses are to design a set of contact lenses for glaucoma, which can be administered according to the activity of glasses
Glaucoma is treated, and ensures that the contact lenses can be administered continuously to glasses, to ensure therapeutic effect.
Background technology
Glaucoma refers to a kind of intraocular pressure intermittently or continually raised eye disease, and lasting intraocular hypertension can give eyeball each several part
Tissue and visual function bring damage, and intraocular pressure, which increases, can cause optic disk (once to claim to regard nipple) recess, defect of visual field, may finally cause
The reason for Severe ophthalmopathy of blindness, glaucoma intraocular pressure increases is that the dynamic equilibrium of aqueous humor circulation receives destruction, and glaucoma is three
One of big blinding disease, should find early, and related effective therapy is taken to be treated.
For glaucoma, traditional therapy such as instil due to its extremely low bioavilability thus therapeutic effect compared with
Difference, and this mode of intraocular injection is used, and containing great risk, greatly side effect may be caused.
The content of the invention
For the disadvantages described above or Improvement requirement of the prior art, it is an object of the invention to provide one kind for treating green light
The contact lenses of eye, wherein passing through the material to contact lenses and eyeglass internal structure (especially micro- fluid passage, hollow cavity
Overall structure and each micro- fluid passage, the concrete shape of hollow cavity and liquid outlet, dimensional parameters of body and liquid outlet etc.)
Design and corresponding technique are improved, and using contact lenses as drug delivery system, are triggered with the abnormal intraocular pressure of glaucoma patient
Administration compared with traditional therapeutic modality using eye drops, is ensureing the contact lenses on the premise of not affecting vision, energy
It is enough to be administered continuously according to liquid microcavity in intraocular pressure rise extruding soft layer, overcome traditional methods of administration that can not ensure and continue
Property therapeutic effect and the defects of poor bioavailability, there is higher bioavilability and lower Operative risk.
To achieve the above object, it is proposed, according to the invention, provide a kind of contact lenses for being used to treat glaucoma, feature exists
In the contact lenses are integrally rendered as the contact lens (1) of spherical crown shape, which is used for when wearing with suffering from
The eyeball shape of person is matchingly bonded；
The contact lens (1) mainly passes through plane bonding technique and heat by soft layer (8) and hard layer (7) two parts
Molded technique is prepared, wherein the soft layer (8) is located at the internal layer of the contact lens (1), for direct and patient
Cornea fit, the hard layer (7) then be located at the contact lens (1) outer layer；
Microfluidic channel (3) and hollow cavity (4) are also formed in the inside of the contact lens (1)；Wherein, it is described
Hollow cavity (4) is used to store liquid medicine (5)；The microfluidic channel (3) is used to convey the liquid medicine (5), one
End is connected with the hollow cavity (4), and the other end is communicated with liquid outlet (2), for being connected with the contact lens (1) external world
It is logical.
As present invention further optimization, the hollow cavity (4) is segment, and the segment is in the Corneal Contact
The circular edge of mirror (1) in the plane be projected as sector, the fan-shaped internal diameter be not less than 2.5mm, outer diameter be 5~6mm, institute
The thickness for stating segment is 100-150um；Preferably, the hollow cavity (4) is multiple that this multiple hollow cavity (4) is fan-shaped
The inner edge of projection and outer rim are distributed along the even circumferential of the circle concentric with the circular edge of the contact lens (1)；In described
Cavity body (4) is preferably 4,6 or 8.
As present invention further optimization, each hollow cavity (4) only with a microfluidic channel (3)
It is connected.
As present invention further optimization, the height of any one microfluidic channel (3) is 20-50um, width
For 50-100um, length 1-3mm.
As present invention further optimization, a diameter of 0.2-0.5mm of the liquid outlet (2)；The liquid outlet (2) is located at
In the soft layer (8) or the hard layer (7) or positioned at the soft layer (8) and the hard layer (7) double-layer structure
Edge.
As present invention further optimization, the liquid medicine (5) be for treating the drug of glaucoma, be preferably β-
Receptor blocker, myotic, prostaglandin derivating agent.
As present invention further optimization, the soft layer (8) and the hard layer (7) by chemical coupling surface at
The mode of reason realizes bonding.
As present invention further optimization, the soft layer (8) uses dimethyl silicone polymer (PDMS) material, thickness
For 250um-350um；The thickness of the hard layer (7) is 100um-250um, which uses gas permeability hard material,
Preferably PMMA, Parylene, PC or PET material.
As present invention further optimization, the dimensions of the contact lens (1) be set to diameter 13mm~
18mm, integral thickness 350-600um.
By the above technical scheme conceived by the present invention, compared with prior art, due to using contact lenses as drug
Delivery system sets micro- fluid passage, hollow cavity (for example, contact lens bag inside the contact lens of contact lenses
Soft layer and hard layer have been included, has inside been designed with hollow microneedle cavity and microfluidic channels；That is, in soft layer and hard layer
Hollow cavity and fluid passageway be set, hollow cavity and microfluidic channel be by the small micropore in soft layer and hard layer/
Chamber collectively constitutes), it, can be according to the abnormal intraocular pressure of patient using the overall co-ordination of micro- fluid passage, hollow cavity and liquid outlet
It is treated to be administered, when glaucoma patient is worn in the present invention for treating the contact lenses of glaucoma, when glaucoma causes
When intraocular pressure raises, eyes of patients cornea will expand, and squeeze soft layer so that microcavity is squeezed the outside extrusion liquid of meeting in soft layer
Body reaches eyeball so as to fulfill treatment, which is added dropwise medication compared to tradition has real-time, continues
The advantages that property.
Contact lenses delivery system in the present invention, the contact lenses are interior containing liquid microcavity and microfluidic channel, work as eye
During pressure rise, the increase of cornea radius of curvature, keratectasia deformation, can pressurize soft layer, and microcavity can also be extruded and make thereon
The therapeutic fluid obtained in microcavity enters microfluidic channel, is flowed out through microfluidic channel liquid outlet by ocular absorption, reaches eye
For ball to reach therapeutic effect, so raising the automatic method for implementing administration by intraocular pressure can ensure that the continuation of drug supplies,
To reach higher bioavilability, reaction type administration；Pharmaceutical liquid concentration stored by hollow cavity can be according to conditions of patients
Serious conditions adjust.The present invention preferably has the microfluidic channel and hollow cavity of given shape and size by setting,
Such as height, width and length by controlling microfluidic channel etc., the pharmaceutical liquid liquid outlet quantity in the unit interval is can control, and
And due to hard layer outside, the pressure disturbance of eyes normal activity (such as blink, rotate eyeball) can be avoided, is realized only by green light
The administration of the abnormal intraocular pressure triggering of eye, realizes automatic feedback administration formula glaucoma treatment.
The present invention provides the continued administration type contact lenses based on micro-fluidic technologies, and the contact lenses are according to eyeball structure
It is manufactured, is divided into soft layer and hard layer (soft layer inside, contacted directly with eyeball surface, hard layer is on the outside),
Containing liquid microcavity in soft layer, by squeezing micro- intracavity liquid can be made to be flowed out by coupled pipeline；In soft layer
The pharmaceutical liquid for the treatment of glaucoma is stored in microcavity, microcavity is directly connected with microchannel, there are multiple liquid in entire soft layer
Microcavity regular distribution, when intraocular pressure raises, will squeeze the liquid microcavity in soft layer make liquid by microchannel flow out and then
Reach ocular surface to be treated, and be preferably provided with multiple microchannels and microcavity is uniformly distributed, it is ensured that drug therapy
Covering is uniform.
Of the invention innovative is applied to micro-fluidic technologies in dosing eyes, after in the prior art with reference to traditional type
It is added dropwise after being administered or receiving the research that the form of drug carries out contact lenses administration device with reference to contact lens material,
A kind of new way of dosing eyes is given, existing mode of the prior art is overcome and the constraint of contact lens material is subject to limit
The defects of making, can not being further improved.The present invention combines wearable micro-fluidic technologies, is incorporated into ophthalmology concrete application research,
That designs is used to treat the contact lenses combination practical application request of xerophthalmia, is administered with contact lenses.And this
Invention in R＆D process it has also been found that at present eye be added dropwise be administered by way of to eyedrops when, only absorbed on a small quantity,
Most regions flow into nasal cavity and lost, so ocular absorption amount is few, and this discovery using micro-fluidic technologies also to provide
Condition, it is not too many to hold dose due to micro-fluidic technologies, while the outlet of micro-fluidic technologies microchannel can design difference, this just makes
Obtaining us can design medicine outlet in the position that be more easy to absorb, and avoid drug wastage.Therefore, the present invention is by stealthy eye
The overall structure of mirror, especially soft layer and matched each detailed structure using the overall co-ordination of each modular construction, utilize
The actions such as blink can squeeze out drug, be administered in real time, have apparent superiority.
In conclusion the mode using contact lenses drug treatment glaucoma employed in the present invention, has tradition drop
The advantages of note and injection therapeutic modality hardly match, which employs the designs of miniature cavities and microfluidic channels, realize
Therapeutic process that is real-time to glaucoma patient, being administered continuously, has bioavailability high, and good penetrability, drug residence time is long,
The features such as easy to use efficient, specifies a direction for treatment glaucoma from now on.
Description of the drawings
Figure 1A, Figure 1B are a kind of miniature cavities of contact lenses for being used to treat fungal keratitis of the present invention and miniature stream
The overlooking the structure diagram of body passage.
Fig. 2 is a kind of schematic cross-sectional view for the contact lenses for being used to treat glaucoma of the present invention.
The meaning of each reference numeral is as follows in figure：1 is contact lens, and 2 for the medicine outlet of microfluidic channels (be liquid
Mouthful), 3 be microfluidic channels, and 4 be hollow microneedle cavity, and 5 be ocular drug (i.e. liquid medicine), and 6 be eyelid, and 7 be hard
Layer, 8 be soft layer, and 9 be cornea.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to the accompanying drawings and embodiments, it is right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.As long as in addition, technical characteristic involved in the various embodiments of the present invention described below
Conflict is not formed each other to can be combined with each other.
For treating the contact lenses of glaucoma in the present invention, real-time can be carried out to glaucoma and continuation is controlled
It treats, entirety is rendered as the contact lens of curved surface, and contact lens is internally provided with soft layer and hard layer, and hard layer is located at
Outside, soft layer, which is located inside, directly to be contacted with eye cornea, and soft layer is bonded with hard layer, and Inner Constitution has the liquid micro-
Chamber wherein including the drug for the treatment of glaucoma, is connected, microchannel is connected with liquid outlet with microchannel.When patient suffers from custom clearance
When eye causes intraocular pressure rise, eye cornea expansion squeezes soft layer so that microcavity, which is squeezed, in soft layer can outwards squeeze out liquid
Eyeball is reached to be treated.
Embodiment 1
As shown in Figure 1A, Figure 1B and Fig. 2, the present invention is a kind of for treating the contact lenses of glaucoma, is integrally rendered as song
The contact lens in face, the contact lens include soft layer, hard layer, hollow microneedle cavity, microfluidic channels etc.
(hollow microneedle cavity and microfluidic channels are arranged in soft layer structure；Hard layer possesses certain intensity, such as 0.1-
The difference of both the Young's modulus of 10GPa ranks, soft layer and hard layer be that material therefor it is soft or hard on, hard layer is hard
In soft layer, correspondingly, soft layer is also softer than hard layer, the soft or hard of material can be according to the degree of material surface local plastic deformation
Compare, the material that Young's modulus is 0.1-10MPa for example may be employed in soft layer).Wherein：
Contact lens integrally in spherical crown shape, fits for the eyeball shape with glaucoma patient.The contact lens
It is superimposed and formed by process with soft layer two parts by hard layer, wherein soft layer is located at the internal layer of contact lens, with
Eyeball surface contacts directly, and hard layer is located at the outer layer of contact lens.The dimensions of contact lens is set to diameter
13mm~18mm；Integral thickness is no more than 600 μm.
Soft layer uses dimethyl silicone polymer (PDMS) material, has nontoxic transparent, good chemical inertness, high saturating
The advantages that oxygen, and its surface can make it have biocompatibility by ion modification, be suitable for cornea wearing.Soft thickness
It spends for 250um-350um.Gas permeability hard material (Ortho-K material) or PMMA, Parylene, PC or PET material,
Translucidus are good, and surface gloss is high, is unlikely to deform.The thickness of hard layer is 100um-250um.
The shape for the closed hollow microneedle cavity (4) that soft layer is bonded together to form with hard layer is segment, the segment
Path is not less than 2.5mm, and major diameter is 5~6mm (such as 5.6mm), thickness 100-150um, in the contact lens (1) inside
It is distributed, can be distributed for four, 6,8 etc. around center annular uniform array.
Any one microfluidic channels height 20-50um, width 50-100um, the length of 1-3mm, minisize fluid lead to
Road (3) is connected with hollow microneedle cavity (4).One hollow microneedle cavity (4) is preferably connected with a microfluidic channels (3)
It is logical.
Microfluidic channels (3) end is connected with liquid outlet (2), which can be located in soft layer (8), hard layer
(7) in or two layers of edge, liquid outlet diameter 0.2-0.5mm.
Liquid medicine (5) should be treatment glaucoma related drugs for example beta-blocker, myotic, prostaglandin spread out
Raw agent etc..
In the present invention, glaucoma patient due to eye pressure raise, keratectasia, radius of curvature increase, angle can be squeezed
The soft layer of film contact lense is squeezed soft layer and Light deformation occurs, and the in vivo liquid drug of hollow microneedle chamber can be squeezed
It is pressed onto in microfluidic channels, and then is exited by minitype channel liquid outlet in the cornea of patient.
By conceiving above, above-mentioned designed contact lens can not disturb the normal life of patient, be not take up
In the case of patient's study and work time, reach real-time, lasting therapeutic effect, improve bioavilability, can alleviate in time
The state of an illness of patient, thus the crowd especially suitable for suffering from relevant disease in current fast pace society uses.
The shape of hollow microneedle cavity can be segment, and the internal diameter of the segment is more than 2.5mm, outer diameter 5-6mm, thick
It spends for 100-150um, using fan-shaped physical efficiency preferably using the space of entire circular contact lenses, increases medicament storage amount, be
Eye visual function is not influenced, and internal diameter design is more than 2.5mm, and outer diameter design 5-6mm is less than contact lenses diameter.It is in addition, multiple
Microcavity uses annular array formal distribution, can more efficient distribution liquid outlet so that administration is uniform, and drug absorption is faster.
Material within Young's modulus 0.1-10MPa may be employed in the soft layer of the present invention, is preferably PDMS material；Hard layer
Young's modulus 0.1-10GPa materials may be employed, be preferably PMMA materials.
Liquid outlet 2 in the present invention has to contact with ambient atmosphere (for example, the cornea of patient cannot be completed to cover
Cover the liquid outlet), otherwise liquid outlet will be unable to output pharmaceutical liquid.Hard layer is to carry out work with soft layer two parts in the present invention
Skill is superimposed.The chemical coupling surface treatment mode of the optional use of the present invention can refer to related art, as APTES silane is even
Connection bonding (can refer to such as Vlachopoulou M E, Tserepi A, Pavli P, et al.A low temperature
surfacemodification assisted method for bonding plastic substrates[J].Journal
of Micromechanics&Microengineering,2009,19(1):15007-15006.)；Hot-forming technique
The prior art (such as can refer to Baidupedia " thermoplastic shaping technique " etc.) may be employed.
As it will be easily appreciated by one skilled in the art that the foregoing is merely illustrative of the preferred embodiments of the present invention, not to
The limitation present invention, all any modification, equivalent and improvement made within the spirit and principles of the invention etc., should all include
Within protection scope of the present invention.
Claims (9)
1. a kind of contact lenses for being used to treat glaucoma, which is characterized in that the contact lenses are integrally rendered as the angle of spherical crown shape
Film contact lense (1), the contact lens (1) are used to matchingly be bonded with the eyeball shape of patient when wearing；
The contact lens (1) mainly by soft layer (8) and hard layer (7) two parts by plane bonding technique with being hot pressed into
Type technique is prepared, wherein the soft layer (8) is located at the internal layer of the contact lens (1), for the eye directly with patient
Cornea fits, and the hard layer (7) is then located at the outer layer of the contact lens (1)；
Microfluidic channel (3) and hollow cavity (4) are also formed in the inside of the contact lens (1)；Wherein, it is described hollow
Cavity (4) is used to store liquid medicine (5)；The microfluidic channel (3) for conveying the liquid medicine (5), its one end with
The hollow cavity (4) is connected, and the other end is communicated with liquid outlet (2), for being connected with contact lens (1) external world.
2. it is used to treat the contact lenses of glaucoma as described in claim 1, which is characterized in that the hollow cavity (4) is fan
Body, the segment the contact lens (1) circular edge in the plane be projected as sector, the fan-shaped internal diameter
Not less than 2.5mm, outer diameter is 5~6mm, and the thickness of the segment is 100-150um；Preferably, the hollow cavity (4) is
Multiple, the inner edge of the fan-shaped projection of this multiple hollow cavity (4) and outer rim are along concentric with the circular edge of the contact lens (1)
Circle even circumferential distribution；The hollow cavity (4) is preferably 4,6 or 8.
3. it is used to treat the contact lenses of glaucoma as described in claim 1, which is characterized in that each hollow cavity (4)
Only it is connected with a microfluidic channel (3).
4. it is used to treat the contact lenses of glaucoma as described in claim 1, which is characterized in that any one microfluid leads to
The height in road (3) is 20-50um, width 50-100um, length 1-3mm.
5. it is used to treat the contact lenses of glaucoma as described in claim 1, which is characterized in that the diameter of the liquid outlet (2)
For 0.2-0.5mm；The liquid outlet (2) is located in the soft layer (8) or the hard layer (7) or positioned at the soft layer
(8) with the edge of the hard layer (7) double-layer structure.
6. it is used to treat the contact lenses of glaucoma as described in claim 1, which is characterized in that the liquid medicine (5) is to use
It is preferably beta-blocker, myotic, prostaglandin derivating agent in the drug for the treatment of glaucoma.
7. as described in claim 1 for treating the contact lenses of glaucoma, which is characterized in that the soft layer (8) and described
Hard layer (7) realizes bonding by way of chemical coupling surface treatment.
8. it is used to treat the contact lenses of glaucoma as described in claim 1, which is characterized in that the soft layer (8) is using poly-
Dimethyl siloxane (PDMS) material, thickness 250um-350um；The thickness of the hard layer (7) is 100um-250um, should
Hard layer (7) uses gas permeability hard material, is preferably PMMA, Parylene, PC or PET material.
9. it is used to treat the contact lenses of glaucoma as described in claim 1, which is characterized in that the contact lens (1)
Dimensions is set to diameter 13mm~18mm, integral thickness 350-600um.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711291361.6A CN108095886B (en) | 2017-12-08 | 2017-12-08 | It is a kind of for treating the contact lenses of glaucoma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711291361.6A CN108095886B (en) | 2017-12-08 | 2017-12-08 | It is a kind of for treating the contact lenses of glaucoma |
Publications (2)
| Publication Number | Publication Date |
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| CN108095886A true CN108095886A (en) | 2018-06-01 |
| CN108095886B CN108095886B (en) | 2019-10-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711291361.6A Expired - Fee Related CN108095886B (en) | 2017-12-08 | 2017-12-08 | It is a kind of for treating the contact lenses of glaucoma |
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| CN108969185A (en) * | 2018-07-06 | 2018-12-11 | 佛山市瑞生海特生物科技有限公司 | Bandage is sterilized by the eyeball that eyelid squeezes sustained release dosage |
| CN110292354A (en) * | 2019-07-12 | 2019-10-01 | 华中科技大学 | Based on the contact lenses vision intraocular pressure sensor of strain sensing mechanism and its preparation |
| CN110367927A (en) * | 2019-08-01 | 2019-10-25 | 中山大学 | Glaucoma intraocular pressure continuous detecting system and its detection method |
| CN110407161A (en) * | 2019-07-12 | 2019-11-05 | 华中科技大学 | A kind of soft curved surface micro-fluidic device manufacturing method based on conformal bonding technology |
| WO2020076349A1 (en) * | 2018-10-10 | 2020-04-16 | Long Que | Contact lens including nanopores |
| US20200201078A1 (en) * | 2018-12-21 | 2020-06-25 | Verily Life Sciences Llc | Fluid-containing contact lens with soft posterior element |
| CN112190229A (en) * | 2020-10-27 | 2021-01-08 | 华中科技大学同济医学院附属同济医院 | Intraocular pressure monitoring device for external rigid-internal soft double-layer corneal contact lens |
| CN112450877A (en) * | 2020-10-27 | 2021-03-09 | 华中科技大学同济医学院附属同济医院 | Intelligent contact lens with full-cornea fiber grating sensors arranged in series |
| GB2588464A (en) * | 2019-10-25 | 2021-04-28 | Coopervision Int Ltd | Multilayer contact lens |
| CN113721374A (en) * | 2021-09-08 | 2021-11-30 | 无锡市第二人民医院 | Contact lenses for direct ocular drug delivery |
| CN114245877A (en) * | 2019-07-24 | 2022-03-25 | 大元制药株式会社 | Contact lens and mold for preparing same |
| GB2604046A (en) * | 2019-10-25 | 2022-08-24 | Coopervision Int Ltd | Multilayer contact lens |
| GB2604243A (en) * | 2019-10-25 | 2022-08-31 | Coopervision Int Ltd | Multilayer contact lens |
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Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108969185B (en) * | 2018-07-06 | 2020-09-29 | 青岛市市立医院 | Eyeball disinfection bandage capable of slowly releasing reagent by extruding eyelid |
| CN108969185A (en) * | 2018-07-06 | 2018-12-11 | 佛山市瑞生海特生物科技有限公司 | Bandage is sterilized by the eyeball that eyelid squeezes sustained release dosage |
| WO2020076349A1 (en) * | 2018-10-10 | 2020-04-16 | Long Que | Contact lens including nanopores |
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| US20200201078A1 (en) * | 2018-12-21 | 2020-06-25 | Verily Life Sciences Llc | Fluid-containing contact lens with soft posterior element |
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| CN110407161B (en) * | 2019-07-12 | 2022-02-15 | 华中科技大学 | Manufacturing method of soft curved surface microfluidic device based on conformal bonding process |
| CN110292354A (en) * | 2019-07-12 | 2019-10-01 | 华中科技大学 | Based on the contact lenses vision intraocular pressure sensor of strain sensing mechanism and its preparation |
| CN110407161A (en) * | 2019-07-12 | 2019-11-05 | 华中科技大学 | A kind of soft curved surface micro-fluidic device manufacturing method based on conformal bonding technology |
| CN114245877A (en) * | 2019-07-24 | 2022-03-25 | 大元制药株式会社 | Contact lens and mold for preparing same |
| CN110367927A (en) * | 2019-08-01 | 2019-10-25 | 中山大学 | Glaucoma intraocular pressure continuous detecting system and its detection method |
| GB2604243A (en) * | 2019-10-25 | 2022-08-31 | Coopervision Int Ltd | Multilayer contact lens |
| GB2588464B (en) * | 2019-10-25 | 2022-04-20 | Coopervision Int Ltd | Multilayer contact lens |
| GB2604046A (en) * | 2019-10-25 | 2022-08-24 | Coopervision Int Ltd | Multilayer contact lens |
| GB2588464A (en) * | 2019-10-25 | 2021-04-28 | Coopervision Int Ltd | Multilayer contact lens |
| US11609440B2 (en) | 2019-10-25 | 2023-03-21 | Coopervision International Limited | Multilayer contact lens |
| GB2604243B (en) * | 2019-10-25 | 2023-09-06 | Coopervision Int Ltd | Multilayer contact lens |
| GB2604046B (en) * | 2019-10-25 | 2023-09-06 | Coopervision Int Ltd | Multilayer contact lens |
| CN112450877A (en) * | 2020-10-27 | 2021-03-09 | 华中科技大学同济医学院附属同济医院 | Intelligent contact lens with full-cornea fiber grating sensors arranged in series |
| CN112190229A (en) * | 2020-10-27 | 2021-01-08 | 华中科技大学同济医学院附属同济医院 | Intraocular pressure monitoring device for external rigid-internal soft double-layer corneal contact lens |
| CN113721374A (en) * | 2021-09-08 | 2021-11-30 | 无锡市第二人民医院 | Contact lenses for direct ocular drug delivery |
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| CN108095886B (en) | 2019-10-25 |
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