CN108095886B - It is a kind of for treating the contact lenses of glaucoma - Google Patents
It is a kind of for treating the contact lenses of glaucoma Download PDFInfo
- Publication number
- CN108095886B CN108095886B CN201711291361.6A CN201711291361A CN108095886B CN 108095886 B CN108095886 B CN 108095886B CN 201711291361 A CN201711291361 A CN 201711291361A CN 108095886 B CN108095886 B CN 108095886B
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- China
- Prior art keywords
- layer
- glaucoma
- contact lenses
- contact lens
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
Abstract
The invention discloses a kind of for treating the contact lenses of glaucoma, its entirety is rendered as the contact lens (1) of spherical crown shape, mainly it is prepared by plane bonding technique with hot press forming technology by soft layer (8) and hard layer (7) two parts, wherein soft layer (8) is located at the internal layer of the contact lens (1), and hard layer (7) is then located at the outer layer of the contact lens (1)；Microfluidic channel (3) and hollow cavity (4) are also formed in the inside of contact lens (1)；Wherein, hollow cavity (4) is for storing liquid medicine (5)；Microfluidic channel (3) is for conveying liquid medicine (5).The present invention is improved by material and eyeglass internal structure to contact lenses and corresponding technique, using contact lenses as drug delivery system, administration is triggered with the abnormal intraocular pressure of glaucoma patient, it can be administered continuously according to liquid microcavity in intraocular pressure raising extruding soft layer, bioavilability is high.
Description
Technical field
The invention belongs to the field of medical instrument technology, more particularly, to a kind of for treating the contact lenses of glaucoma,
The contact lenses are to design a set of contact lenses for glaucoma, which can be administered according to the activity of glasses
Glaucoma is treated, and guarantees that the contact lenses can be administered continuously to glasses, to guarantee therapeutic effect.
Background technique
Glaucoma refers to a kind of intraocular pressure intermittently or continually raised eye disease, and lasting intraocular hypertension can give eyeball each section
Tissue and visual function bring damage, and intraocular pressure, which increases, can cause optic disk (once claiming view nipple) recess, defect of visual field, may finally cause
The reason of Severe ophthalmopathy of blindness, glaucoma intraocular pressure increases is that the dynamic equilibrium of aqueous humor circulation receives destruction, and glaucoma is three
One of big blinding disease, should find early, and related effective treatment method is taken to be treated.
For glaucoma, traditional treatment method such as instil due to its extremely low bioavilability thus therapeutic effect compared with
Difference, and this mode of intraocular injection is used, and contain great risk, it may cause greatly side effect.
Summary of the invention
Aiming at the above defects or improvement requirements of the prior art, the purpose of the present invention is to provide one kind for treating green light
The contact lenses of eye, wherein passing through material and eyeglass internal structure (especially micro- fluid passage, hollow cavity to contact lenses
The overall structure and concrete shape, the dimensional parameters of each micro- fluid passage, hollow cavity and liquid outlet etc. of body and liquid outlet)
Design and corresponding technique improve, and using contact lenses as drug delivery system, are triggered with the abnormal intraocular pressure of glaucoma patient
Administration, compared with traditional therapeutic modality using eye drops, guarantee the contact lenses under the premise of not affecting vision, energy
It is enough to be administered continuously according to liquid microcavity in intraocular pressure raising extruding soft layer, overcome traditional methods of administration that can not ensure and continues
Property therapeutic effect and the defects of poor bioavailability, there is higher bioavilability and lower Operative risk.
To achieve the above object, it is proposed, according to the invention, provide a kind of for treating the contact lenses of glaucoma, feature exists
In the contact lenses are integrally rendered as the contact lens (1) of spherical crown shape, which is used for when wearing and suffers from
The eyeball shape of person is matchingly bonded；
The contact lens (1) mainly passes through plane bonding technique and heat by soft layer (8) and hard layer (7) two parts
Molded technique is prepared, wherein the soft layer (8) is located at the internal layer of the contact lens (1), for directly and patient
Cornea fit, the hard layer (7) then be located at the contact lens (1) outer layer；
Microfluidic channel (3) and hollow cavity (4) are also formed in the inside of the contact lens (1)；Wherein, described
Hollow cavity (4) is for storing liquid medicine (5)；The microfluidic channel (3) is for conveying the liquid medicine (5), one
End is connected with the hollow cavity (4), and the other end is communicated with liquid outlet (2), for being connected with the contact lens (1) external world
It is logical.
As present invention further optimization, the hollow cavity (4) is segment, and the segment is in the Corneal Contact
The circular edge of mirror (1) in the plane be projected as sector, the internal diameter of the sector is not less than 2.5mm, and outer diameter is 5~6mm, institute
State segment with a thickness of 100-150um；Preferably, the hollow cavity (4) is multiple, this multiple hollow cavity (4) is fan-shaped
The inner edge of projection and outer rim are distributed along the even circumferential of the circle concentric with the circular edge of the contact lens (1)；In described
Cavity body (4) is preferably 4,6 or 8.
As present invention further optimization, each hollow cavity (4) only with a microfluidic channel (3)
It is connected.
As present invention further optimization, the height of any one microfluidic channel (3) is 20-50um, width
For 50-100um, length 1-3mm.
As present invention further optimization, the diameter of the liquid outlet (2) is 0.2-0.5mm；The liquid outlet (2) is located at
In the soft layer (8) or the hard layer (7), or it is located at the soft layer (8) and the hard layer (7) double-layer structure
Edge.
As present invention further optimization, the liquid medicine (5) is the drug for treating glaucoma, preferably β-
Receptor blocker, myotic, prostaglandin derivating agent.
As present invention further optimization, the soft layer (8) and the hard layer (7) pass through at chemical coupling surface
The mode of reason realizes bonding.
As present invention further optimization, the soft layer (8) uses dimethyl silicone polymer (PDMS) material, thickness
For 250um-350um；The hard layer (7) with a thickness of 100um-250um, which uses gas permeability hard material,
Preferably PMMA, Parylene, PC or PET material.
As present invention further optimization, the dimensions of the contact lens (1) be set to diameter 13mm~
18mm, integral thickness 350-600um.
Contemplated above technical scheme through the invention, compared with prior art, due to using contact lenses as drug
Micro- fluid passage, hollow cavity is arranged (for example, contact lens packet in delivery system inside the contact lens of contact lenses
Soft layer and hard layer are included, interior design has hollow microneedle cavity and microfluidic channels；That is, in soft layer and hard layer
Hollow cavity and fluid channel be set, hollow cavity and microfluidic channel be by the small micropore in soft layer and hard layer/
Chamber collectively constitutes), it, can be according to the abnormal intraocular pressure of patient using the overall co-ordination of micro- fluid passage, hollow cavity and liquid outlet
It is treated to be administered, when glaucoma patient is worn in the present invention for treating the contact lenses of glaucoma, when glaucoma causes
When intraocular pressure increases, eyes of patients cornea will expand, and squeeze soft layer, so that microcavity is squeezed the outside extrusion liquid of meeting in soft layer
Body reaches eyeball to realize treatment, which, which is added dropwise medication compared to tradition, has real-time, continues
The advantages that property.
Contact lenses drug delivery system in the present invention, the contact lenses are interior to contain liquid microcavity and microfluidic channel, works as eye
When pressure increases, cornea radius of curvature increases, and keratectasia deformation, can pressurize soft layer, and microcavity can also be extruded and make thereon
The therapeutic fluid obtained in microcavity enters microfluidic channel, through the outflow of microfluidic channel liquid outlet by ocular absorption, reaches eye
Ball can guarantee that the duration of drug supplies by the method that intraocular pressure increases automatic implementation administration in this way to reach therapeutic effect,
To reach higher bioavilability, reaction type administration；Pharmaceutical liquid concentration stored by hollow cavity can be according to conditions of patients
Serious conditions adjustment.The present invention preferably passes through the microfluidic channel and hollow cavity that setting has specific shape and size,
Such as height, width and length etc. by controlling microfluidic channel, it can control the pharmaceutical liquid liquid outlet quantity in the unit time, and
And outside due to hard layer, the pressure disturbance that can avoid eyes normal activity (such as blink, rotate eyeball), is realized only by green light
The administration of the abnormal intraocular pressure triggering of eye, realizes that formula glaucoma treatment is administered in automatic feedback.
The present invention provides the continued administration type contact lenses based on micro-fluidic technologies, and the contact lenses are according to eyeball structure
It is manufactured, is divided into soft layer and hard layer (soft layer is directly contacted in inside, with eyeball surface, and hard layer is on the outside),
Contain liquid microcavity in soft layer, micro- intracavity liquid can be made to flow out by coupled pipeline by squeezing；In soft layer
The pharmaceutical liquid for the treatment of glaucoma is stored in microcavity, microcavity is directly connected with microchannel, there are multiple liquid in entire soft layer
Microcavity regular distribution, when intraocular pressure increases, will squeeze the liquid microcavity in soft layer flows out liquid by microchannel
Reach ocular surface to be treated, and be preferably provided with multiple microchannels and microcavity is uniformly distributed, it is ensured that drug therapy
Covering is uniform.
Of the invention innovative is applied to micro-fluidic technologies in ophthalmic administration, after in the prior art in conjunction with traditional type
It is added dropwise to be administered or the form of drug is received to carry out contact lenses in conjunction with contact lens material and be administered after the research of device,
A kind of new way of ophthalmic administration is given, the constraint for overcoming existing mode in the prior art by contact lens material limits
System, can not further improved defect.The present invention combines wearable micro-fluidic technologies, is incorporated into ophthalmology concrete application research,
That designs is used to treat the contact lenses combination practical application request of xerophthalmia, is administered with contact lenses.And this
Invention in R&D process it has also been found that at present eye be added dropwise administration by way of to eyedrops when, be only absorbed on a small quantity,
Most regions flow into nasal cavity and lost, so ocular absorption amount is few, and this discovery using micro-fluidic technologies also to provide
Condition, it is not too many for holding dose due to micro-fluidic technologies, while the outlet of micro-fluidic technologies microchannel can design difference, this just makes
Obtaining us can design medicine outlet in the position for being easier to absorb, and avoid drug wastage.Therefore, the present invention passes through to stealthy eye
The overall structure of mirror, especially soft layer and matched each detailed structure are utilized using the overall co-ordination of each modular construction
The movements such as blink can squeeze out drug, be administered in real time, have apparent superiority.
In conclusion it is employed in the present invention in the way of contact lenses drug treatment glaucoma, there is tradition drop
The advantages of note and injection therapeutic modality hardly match, which employs the designs of miniature cavities and microfluidic channels, realize
Therapeutic process that is real-time to glaucoma patient, being administered continuously, has bioavailability high, and good penetrability, drug residence time is long,
The features such as easy to use efficient, specifies a direction for treatment glaucoma from now on.
Detailed description of the invention
Figure 1A, Figure 1B are a kind of miniature cavities and miniature stream for treating the contact lenses of fungal keratitis of the present invention
The overlooking structure diagram in body channel.
Fig. 2 is that the present invention is a kind of for treating the schematic cross-sectional view of the contact lenses of glaucoma.
The meaning of each appended drawing reference is as follows in figure: 1 is contact lens, and 2 (go out liquid for the medicine outlet of microfluidic channels
Mouthful), 3 be microfluidic channels, and 4 be hollow microneedle cavity, and 5 be ocular drug (i.e. liquid medicine), and 6 be eyelid, and 7 be hard
Layer, 8 be soft layer, and 9 be cornea.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.As long as in addition, technical characteristic involved in the various embodiments of the present invention described below
Not constituting a conflict with each other can be combined with each other.
For treating the contact lenses of glaucoma in the present invention, real-time can be carried out to glaucoma and duration is controlled
It treats, entirety is rendered as the contact lens of curved surface, and contact lens is internally provided with soft layer and hard layer, and hard layer is located at
Outside, soft layer, which is located inside, directly to be contacted with eye cornea, and soft layer is bonded with hard layer, and Inner Constitution has liquid micro-
Chamber, wherein the drug comprising treatment glaucoma, is connected, microchannel is connected with liquid outlet with microchannel.When patient suffers from custom clearance
When eye causes intraocular pressure to increase, eye cornea expansion squeezes soft layer, so that microcavity is squeezed and can squeeze out liquid outward in soft layer
Eyeball is reached to be treated.
Embodiment 1
As shown in Figure 1A, Figure 1B and Fig. 2, the present invention is a kind of for treating the contact lenses of glaucoma, is integrally rendered as song
The contact lens in face, the contact lens include soft layer, hard layer, hollow microneedle cavity, microfluidic channels etc.
(hollow microneedle cavity and microfluidic channels are set in soft layer structure；Hard layer has certain intensity, such as 0.1-
The difference of both the Young's modulus of 10GPa rank, soft layer and hard layer be that material therefor it is soft or hard on, hard layer is hard
In soft layer, correspondingly, soft layer is also softer than hard layer, the soft or hard of material can be according to the degree of material surface local plastic deformation
Compare, soft layer for example can use Young's modulus for the material of 0.1-10MPa).Wherein:
Contact lens is integrally in spherical crown shape, is fitted for the eyeball shape with glaucoma patient.The contact lens
It is superimposed and is constituted by process with soft layer two parts by hard layer, wherein soft layer is located at the internal layer of contact lens, with
Eyeball surface directly contacts, and hard layer is located at the outer layer of contact lens.The dimensions of contact lens is set to diameter
13mm~18mm；Integral thickness is no more than 600 μm.
Soft layer uses dimethyl silicone polymer (PDMS) material, with nontoxic transparent, good chemical inertness, high saturating
The advantages that oxygen, and its surface can make it have biocompatibility by ion modification, be suitable for cornea wearing.Soft thickness
Degree is 250um-350um.Gas permeability hard material (Ortho-K material), can also be PMMA, Parylene, PC or PET material,
Translucidus is good, and surface gloss is high, is unlikely to deform.Hard layer with a thickness of 100um-250um.
The shape for the closed hollow microneedle cavity (4) that soft layer and hard layer bond together to form is segment, the segment
Path is not less than 2.5mm, and major diameter is 5~6mm (such as 5.6mm), internal in the contact lens (1) with a thickness of 100-150um
It is distributed around center annular uniform array, can be four distributions, 6,8 etc..
Any one microfluidic channels height 20-50um, width 50-100um, the length is 1-3mm, minisize fluid is logical
Road (3) is connected with hollow microneedle cavity (4).One hollow microneedle cavity (4) is preferably connected with a microfluidic channels (3)
It is logical.
Microfluidic channels (3) end is connected with liquid outlet (2), which can be in soft layer (8), hard layer
(7) in or two layers of edge, liquid outlet diameter 0.2-0.5mm.
Liquid medicine (5) should be treatment glaucoma related drugs for example beta-blocker, myotic, prostaglandin spread out
Raw agent etc..
In the present invention, glaucoma patient due to eye pressure increase, keratectasia, radius of curvature increase, angle can be squeezed
The soft layer of film contact lense is squeezed soft layer and Light deformation occurs, and the intracorporal liquid drug of hollow microneedle chamber can be squeezed
It is pressed onto microfluidic channels, and then is exited into the cornea of patient by minitype channel liquid outlet.
By conceiving above, above-mentioned designed contact lens can not interfere the normal life of patient, be not take up
In the case where patient's study and work time, reach real-time, lasting therapeutic effect, improves bioavilability, can alleviate in time
The state of an illness of patient, thus especially suitable for crowd's use in current fast pace society with related disease.
The shape of hollow microneedle cavity can be segment, and the internal diameter of the segment is greater than 2.5mm, outer diameter 5-6mm, thick
Degree is 100-150um, and the space of entire round contact lenses is preferably utilized using fan-shaped physical efficiency, increases medicament storage amount, is
Eye visual function is not influenced, and internal diameter design is greater than 2.5mm, and outer diameter designs 5-6mm and is less than contact lenses diameter.In addition, multiple
Microcavity use annular array formal distribution, can more efficient distribution liquid outlet so that administration uniformly, drug absorption is faster.
Soft layer of the invention can be using material, preferably PDMS material within Young's modulus 0.1-10MPa；Hard layer
Young's modulus 0.1-10GPa material, preferably PMMA material can be used.
Liquid outlet 2 in the present invention has to contact with ambient atmosphere (for example, the cornea of patient cannot be completed to cover
Cover the liquid outlet), otherwise liquid outlet will be unable to output pharmaceutical liquid.Hard layer and soft layer two parts are to carry out work in the present invention
Skill superposition.The chemical coupling surface treatment mode of the optional use of the present invention can refer to related art, as APTES silane is even
Connection bonding (can refer to such as Vlachopoulou M E, Tserepi A, Pavli P, et al.A low temperature
surfacemodification assisted method for bonding plastic substrates[J].Journal
of Micromechanics&Microengineering,2009,19(1):15007-15006.)；Hot-forming technique
It can be using the prior art (such as can refer to Baidupedia " thermoplastic shaping technique " etc.).
As it will be easily appreciated by one skilled in the art that the foregoing is merely illustrative of the preferred embodiments of the present invention, not to
The limitation present invention, any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should all include
Within protection scope of the present invention.
Claims (8)
1. a kind of for treating the contact lenses of glaucoma, which is characterized in that the contact lenses are integrally rendered as the angle of spherical crown shape
Film contact lense (1), the contact lens (1) are used to matchingly be bonded when wearing with the eyeball shape of patient；
The contact lens (1) is mainly passed through plane bonding technique and is hot pressed by soft layer (8) and hard layer (7) two parts
Type technique is prepared, wherein the soft layer (8) is located at the internal layer of the contact lens (1), for directly with the eye of patient
Cornea fits, and the hard layer (7) is then located at the outer layer of the contact lens (1)；Wherein, the Young of the hard layer (7)
Modulus meets 0.1-10GPa, and the Young's modulus of the soft layer (8) meets 0.1-10MPa；
Microfluidic channel (3) and hollow cavity (4) are also formed in the inside of the contact lens (1)；Wherein, described hollow
Cavity (4) is for storing liquid medicine (5)；The microfluidic channel (3) for conveying the liquid medicine (5), one end with
The hollow cavity (4) is connected, and the other end is communicated with liquid outlet (2), for being connected with contact lens (1) external world；
The hollow cavity (4) is segment, the segment the contact lens (1) circular edge in the plane
Be projected as sector, the internal diameter of the sector is not less than 2.5mm, and outer diameter is 5~6mm, the segment with a thickness of 100-150um；
Each hollow cavity (4) is only connected with a microfluidic channel (3)；Any one microfluid is logical
The height in road (3) is 20-50um, width 50-100um, length 1-3mm；
The diameter of the liquid outlet (2) is 0.2-0.5mm；The liquid outlet (2) is located at the soft layer (8) or the hard layer
(7) in, or it is located at the edge of the soft layer (8) and the hard layer (7) double-layer structure；And the liquid outlet (2) exists
Contact lenses still are able to be kept in contact with ambient atmosphere when being worn.
2. as described in claim 1 for treating the contact lenses of glaucoma, which is characterized in that the hollow cavity (4) is more
A, the inner edge of the fan-shaped projection of this multiple hollow cavity (4) and outer rim are along concentric with the circular edge of the contact lens (1)
Round even circumferential distribution；The hollow cavity (4) is 4,6 or 8.
3. as described in claim 1 for treating the contact lenses of glaucoma, which is characterized in that the liquid medicine (5) is to use
In the drug for the treatment of glaucoma.
4. as claimed in claim 3 for treating the contact lenses of glaucoma, which is characterized in that described for treating glaucoma
Drug is beta-blocker, myotic or prostaglandin derivating agent.
5. as described in claim 1 for treating the contact lenses of glaucoma, which is characterized in that the soft layer (8) and described
Hard layer (7) realizes bonding in such a way that chemical coupling is surface-treated.
6. as described in claim 1 for treating the contact lenses of glaucoma, which is characterized in that the soft layer (8) is using poly-
Dimethyl siloxane (PDMS) material, with a thickness of 250um-350um；The hard layer (7) with a thickness of 100um-250um, should
Hard layer (7) uses gas permeability hard material.
7. as claimed in claim 6 for treating the contact lenses of glaucoma, which is characterized in that the gas permeability hard material is
PMMA, Parylene, PC or PET material.
8. as described in claim 1 for treating the contact lenses of glaucoma, which is characterized in that the contact lens (1)
Dimensions is set to diameter 13mm~18mm, integral thickness 350-600um.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711291361.6A CN108095886B (en) | 2017-12-08 | 2017-12-08 | It is a kind of for treating the contact lenses of glaucoma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711291361.6A CN108095886B (en) | 2017-12-08 | 2017-12-08 | It is a kind of for treating the contact lenses of glaucoma |
Publications (2)
| Publication Number | Publication Date |
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| CN108095886A CN108095886A (en) | 2018-06-01 |
| CN108095886B true CN108095886B (en) | 2019-10-25 |
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ID=62209320
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| Application Number | Title | Priority Date | Filing Date |
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| CN201711291361.6A Expired - Fee Related CN108095886B (en) | 2017-12-08 | 2017-12-08 | It is a kind of for treating the contact lenses of glaucoma |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108969185B (en) * | 2018-07-06 | 2020-09-29 | 青岛市市立医院 | Eyeball disinfection bandage capable of slowly releasing reagent by extruding eyelid |
| US11947195B2 (en) | 2018-10-10 | 2024-04-02 | Iowa State University Research Foundation, Inc. | Contact lens including nanopores |
| US11703697B2 (en) * | 2018-12-21 | 2023-07-18 | Verily Life Sciences Llc | Fluid-containing contact lens with soft posterior element |
| CN110407161B (en) * | 2019-07-12 | 2022-02-15 | 华中科技大学 | Manufacturing method of soft curved surface microfluidic device based on conformal bonding process |
| CN110292354A (en) * | 2019-07-12 | 2019-10-01 | 华中科技大学 | Based on the contact lenses vision intraocular pressure sensor of strain sensing mechanism and its preparation |
| EP4006625A4 (en) * | 2019-07-24 | 2023-09-06 | Dae Won Pharmaceutical Co., Ltd. | Contact lens and mold for manufacturing same |
| CN110367927B (en) * | 2019-08-01 | 2022-04-08 | 中山大学 | Glaucoma intraocular pressure continuous detection system and detection method thereof |
| GB2604243B (en) * | 2019-10-25 | 2023-09-06 | Coopervision Int Ltd | Multilayer contact lens |
| GB2588464B (en) | 2019-10-25 | 2022-04-20 | Coopervision Int Ltd | Multilayer contact lens |
| GB2604046B (en) * | 2019-10-25 | 2023-09-06 | Coopervision Int Ltd | Multilayer contact lens |
| CN112190229A (en) * | 2020-10-27 | 2021-01-08 | 华中科技大学同济医学院附属同济医院 | Intraocular pressure monitoring device for external rigid-internal soft double-layer corneal contact lens |
| CN112450877A (en) * | 2020-10-27 | 2021-03-09 | 华中科技大学同济医学院附属同济医院 | Intelligent contact lens with full-cornea fiber grating sensors arranged in series |
| CN113721374A (en) * | 2021-09-08 | 2021-11-30 | 无锡市第二人民医院 | Contact lenses for direct ocular drug delivery |
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| CN206515567U (en) * | 2017-03-06 | 2017-09-22 | 重庆医药高等专科学校 | One kind carries property of medicine contact lens |
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| US20080317819A1 (en) * | 2007-06-21 | 2008-12-25 | Orilla Werhner C | Iop lowering drug combination or non-combination loaded contact lens with zonal drug delivery areas |
| US10031348B2 (en) * | 2014-10-15 | 2018-07-24 | California Institute Of Technology | Contact lens with metered liquid system |
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|---|---|---|---|---|
| CN103300967A (en) * | 2012-03-13 | 2013-09-18 | 庄臣及庄臣视力保护公司 | Dynamic fluid zones in contact lenses |
| CN206515567U (en) * | 2017-03-06 | 2017-09-22 | 重庆医药高等专科学校 | One kind carries property of medicine contact lens |
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| CN108095886A (en) | 2018-06-01 |
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Granted publication date: 20191025 Termination date: 20201208 |