CN110367927A - Glaucoma intraocular pressure continuous detecting system and its detection method - Google Patents
Glaucoma intraocular pressure continuous detecting system and its detection method Download PDFInfo
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- CN110367927A CN110367927A CN201910707368.4A CN201910707368A CN110367927A CN 110367927 A CN110367927 A CN 110367927A CN 201910707368 A CN201910707368 A CN 201910707368A CN 110367927 A CN110367927 A CN 110367927A
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- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
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Abstract
The invention belongs to the detections of ophthalmology disease and treatment technology field, specific open glaucoma intraocular pressure continuously detects and drug delivery system, including contact lens, detection of eyeball tension circuit, drug delivery circuit are integrated in contact lens, detection of eyeball tension circuit is for detecting intraocular pressure information and being wirelessly transferred to the single-chip microcontroller outside contact lens, single-chip microcontroller judges intraocular pressure height according to the information received, when intraocular pressure is higher than normal range (NR), single-chip microcontroller is that drug delivery circuit carries out wireless power, and carries out delivery drug after passing through drug delivery circuit rectifies.The detection system can detect to long-time continuity the fluctuation of intraocular pressure and the abnormal of intraocular pressure increases, and controlled drug delivery can be carried out by the way of ion swimming in time when intraocular pressure exceeds normal range (NR), guarantee intraocular pressure real-time detection and timely, efficient, controllable drug therapy.Additionally have many advantages, such as that portable, smaller to Ocular irritation, diagnosing and treating glaucoma is not high by place and time restriction, utilization ratio of drug.
Description
Technical field
The invention belongs to the detection system technical field of ophthalmology disease, in particular to a kind of glaucoma intraocular pressure continuously detect and
Treatment system and its detection method.
Background technique
Glaucoma refers to the intraocular pressure intermittently or continually common difficult eye disease of raised one kind, and this lasting intraocular hypertension can be with
Eyeball each section tissue damaged, optic atrophy is caused even to blind so as to cause visual field constriction, hypopsia.More allow people's worry
Be glaucoma be to occupy the first irreversibility diseases causing blindness in the world at present, influence more serious than cataract.In addition, green
The intraocular pressure of light eye patient can be increased sharply in a short time, make the patient feels to headache, ophthalmodynia, if not in time will
Intraocular pressure is controlled to normal level, can cause corneal edema, blinding in a short time.Even more noteworthy glaucoma is any
The crowd of age bracket can fall ill, from the baby being just born until the old man in the year of advanced in years may suffer from this disease.Furthermore in people
In the life of class, 90% external information is to need just to be obtained by the eyes of the mankind.Visual field constriction caused by glaucoma,
Hypopsia, which is even blinded, can be greatly reduced the quality of life of patient.
Glaucoma is often extremely caused by intraocular aqueous humor circulation, and aqueous humor results from the ciliary body of eyes back room, passes through
Pupil flows into anterior chamber, is mainly used for the shape of ocular tissue moistened, maintain eyeball and the visual performance of eyes.It is arranged from eye
There are mainly three types of channels out；The first: about 80~90% aqueous humor is discharged through the trabecular network channel of anterior chamber angle, and second: about
10~20% aqueous humor is discharged through uveal scleral channel, the third: about 5% aqueous humor is absorbed through iris surface crypts, remaining
Minimal amount of aqueous humor is discharged through vitreum and retina.The generation of aqueous humor is provided with discharge dynamic equilibrium achieved for eyeball
Intraocular pressure.Suitable intraocular pressure can maintain the shape of eyeball and the visual performance of eyes.However aqueous humor generates excessive or stream
It is obstructed out and will lead to the raising of intraocular pressure, the clinical characters of glaucoma are mainly that the abnormal of intraocular pressure increases.If glaucoma patient
Without properly treatment or malpractice, easily cause irreversible visual field constriction, visual function decline and ocular tissue damage and into
Caused by optic atrophy and blindness.
The treatment of glaucoma at this stage mainly determines blueness by optic disc morphology variation or frequent detection intraocular pressure value
The state of an illness of light eye, miosis class or optic nerve protection class drug, which is added dropwise, in eye when intraocular pressure is more than normal range (NR) reduces intraocular pressure or guarantor
Optic nerve is protected, modus operandi excision trabecular network or part iris is taken to ensure the unimpeded of aqueous humor flow pass when necessary.
Because glaucoma is with higher irreversible blinding, and the intraocular pressure raising to happen suddenly can cause to suffer from short time
Person's blindness, so find glaucoma conditions as soon as possible and accurately judge the state of an illness, and effectively and in time drug delivery with reality
Existing Morbidity control is the reasonable approach for preventing and treating glaucoma.And the discovery as early as possible of glaucoma conditions and the accurate state of an illness are sentenced
It is disconnected, need timely to track and record glaucoma conditions generation, development, the blindings such as the daily intraocular pressure raising of patient and fluctuation most
Risk factor.
Currently, clinically being collapsed frequently with Goldmann applanation tonometer, Schiotz for the diagnosis of glaucoma
The instruments such as tonometer and non-contact tonometer, and tonometry is provided under the operation of specialist for glaucoma patient.
The principle of Goldmann applanation tonometer is using enough strength by cornea applanation, can be according to needed for flattening fixed area
The size of power, or the measurement of intraocular pressure is realized according to the size that constant pressure is flattened is applied.Schiotz collapses intraocular pressure
The working principle of meter is that cornea is extruded recess to realize the measurement of intraocular pressure with the weight of tonometer counterweight.Non-contact tonometer
And a kind of planishing type tonometer is being flattened into its working principle is that providing pressure using air pulse for cornea according to cornea
Time required for fixed-area realizes the measurement of intraocular pressure.But these planishing types, pressure-sinking type and non-contact tonometer are equal
It cannot achieve the continuity tonometry in longer period of time.
In recent years, academia and industrial circle propose some based on MEMS, micro-fluidic, photonic crystal and flexible electronic skill
The detection of eyeball tension device of art, these detection of eyeball tension devices this physical signal of intraocular pressure can be changed into electrically or optically signal from
And realize successional detection of eyeball tension, with solve at present clinically through frequently with planishing type, pressure-sinking type and noncontact type tonometer
Meter can not continuously measure the predicament of intraocular pressure.
Clinically mainly use the drugs such as timolol, pilocarpine with the shape of eye drops the treatment of glaucoma at this stage
Formula is added dropwise in eyes of patients to realize the treatment to glaucoma.However this traditional ocular drug release manner is asked there are many
Topic:
First, the drug being added dropwise in eye is easy to quickly be diluted or removed by tear；
Second, correlative study shows that 50%~100% drug can enter alimentary canal and blood circulation system through nasolacrimal duct
System, thus eye drops formula drug practical efficiency it is extremely low and of short duration in the remaining time of eye；
Third is added dropwise eye drops and needs certain skill, is unsuitable for the elderly and the disabled, furthermore certain treatment glaucomas
Drug (such as timolol) can also cause arrhythmia cordis and bronchial spasm tight after nasolacrimal duct enters human recycle system
Weight consequence.
Other than eye drops formula drug delivery mode, academia proposes one kind using contact lens as carrier in recent years
Ocular drug release manner, contact lens is impregnated by drug solution or is polymerize using the raw material of contact lens with drug
Etc. modes, drug is loaded on contact lens.When glaucoma patient wears such contact lens for carrying drug, due to
That there are drug concentrations is poor for contact lens and ocular tissue, and drug molecule is able in a dispersive manner in eye slow release, warp
It crosses cornea or conjunctiva and is entered eye anterior chamber position.The drugs such as timolol, pilocarpine can be improved in this drug delivery mode
In the remaining time of eye, the slow release of drug is realized.
Summary of the invention
The purpose of the present invention is overcome the deficiencies in the prior art, specifically disclose a kind of glaucoma intraocular pressure continuous detecting system,
The detection system can detect to long-time continuity the fluctuation of intraocular pressure and the abnormal of intraocular pressure increases, and exceed normal model in intraocular pressure
Carry out controlled drug delivery by the way of ion swimming in time when enclosing, guarantee intraocular pressure real-time detection and in time, efficiently, it is controllable
Drug therapy.Furthermore the detection system also have portable, smaller to Ocular irritation, diagnosing and treating glaucoma not by place and
The features such as time restriction, high utilization ratio of drug.
In order to reach above-mentioned technical purpose, the present invention is realized by following technical scheme:
Glaucoma intraocular pressure continuous detecting system of the present invention, including contact lens integrate in the contact lens
There is detection of eyeball tension circuit, include the drug delivery circuit for treating glaucoma medicine, the detection of eyeball tension circuit, drug are thrown
Circuit is passed wirelessly to connect with the single-chip microcontroller outside contact lens；
The detection of eyeball tension circuit is for detecting intraocular pressure information and being wirelessly transferred to list after carrying out signal conversion
Piece machine, single-chip microcontroller judge the height of intraocular pressure according to the information received, and when intraocular pressure is higher than normal range (NR), single-chip microcontroller is drug throwing
It passs circuit and carries out wireless power, and promoted in the form of constant potential or electric current after drug delivery circuit rectifies for electric energy
Electrically charged glaucoma (timolol, pilocarpine) enters eyes anterior chamber position by corneal osmosis, causes small
Weir cellular contraction promotes discharge of the aqueous humor from eyes anterior chamber, realizes therapeutic effect.
As the further improvement of above-mentioned technology, the detection of eyeball tension circuit can be changed by inductance coil L1 and pole plate spacing
Capacitor C1 connects to form LC resonance circuit, and the detection of eyeball tension circuit is wirelessly connected by detection of eyeball tension antenna with chip microcontroller
It connects.
As the further improvement of above-mentioned technology, the drug delivery circuit include inductance coil L2, diode D2 and
Definite value capacitor C2, the inductance coil L2 is coupled with drug delivery antenna realizes wireless power transmission, sets on the drug delivery circuit
There are positive electrode and negative electrode, coating includes the water-setting for treating glaucoma medicine on the positive electrode of drug delivery circuit
Glue.
As the further improvement of above-mentioned technology, the capacitance pressure transducer, detects that intraocular pressure is higher than minimum intraocular pressure
When threshold value, single-chip microcontroller controls drug delivery antenna and applies the alternating electric field of specific frequency with the drug delivery electricity in contact lens
Road coupling carries out wireless power for drug delivery circuit, which is 21mmHg.
In the present invention, the contact lens is flexible contact mirror, and material is dimethyl silicone polymer (PDMS), gathers
2-hydroxyethyl methacry-late (pHEMA), silicone-hydrogel (SiH), polyethylene terephthalate (PET), Parylene or poly-
Urethane (TPU), configuration design can be combined with dioptric technology.
In the present invention, the eye medicinal is pilocarpine drug or timolol drug.
In addition, the invention also discloses the detection method of the glaucoma intraocular pressure continuous detecting system, specific steps
It is:
Capacitance pressure transducer, by detecting intraocular pressure detects intraocular pressure and the variation and fluctuation of lasting monitoring intraocular pressure；
The fluctuation of intraocular pressure is so that the capacitor plate spacing of capacitance pressure transducer, changes, so as to cause capacitance change
Change, and then cause the variation of resonant frequency of detection of eyeball tension circuit, this mechanical signal is changed into electrical signal by intraocular pressure；
When resonant frequency of the ac frequency of the detection of eyeball tension antenna close to detection of eyeball tension circuit, it may occur that altogether
Vibration, is wirelessly transferred to single-chip microcontroller for the resonant frequency of detection of eyeball tension circuit；
By scanning the resonant frequency of intraocular pressure sensor, to obtain varieties of intraocular pressure information；Single-chip microcontroller is according to the letter of acquisition
Breath judges the height of intraocular pressure, and when intraocular pressure is higher than lowest threshold, single-chip microcontroller controls the friendship that drug delivery antenna applies certain frequency
Changed electric field carries out wireless power with the drug delivery circuit coupling in contact lens for drug delivery circuit；
The received electric energy of drug delivery circuit by diode D2 rectify after for electric energy with the shape of constant potential or electric current
Formula driving pilocarpine drug molecule enters eye anterior chamber position through cornea and tm cells is caused to be shunk, and aqueous humor is able to smooth
Outflow causes intraocular pressure to reduce, and realizes drug delivery to treat glaucoma.
In above-mentioned steps (4), the lowest threshold of intraocular pressure is 21mmHg.
In above-mentioned steps (4), single-chip microcontroller control drug delivery antenna apply alternating electric field certain frequency be 10MHz~
15MHz。
The contact lens is flexible contact mirror, and configuration design can be combined with dioptric technology.
Compared with prior art, the beneficial effects of the present invention are:
1, the eye that glaucoma intraocular pressure continuous detecting system of the present invention is flexible contact lens and its inside includes
Press detection circuit and drug delivery circuit.The detection of eyeball tension circuit can be used for the intraocular pressure liter tracked in time and record patient is daily
The generation of the glaucoma conditions such as high and fluctuation develops, the most risk factor of blinding, provides sufficient data for doctor to find early
Make with treatment glaucoma or to glaucoma progression of the disease the foundation of Accurate Diagnosis；Drug delivery circuit is higher than normally when intraocular pressure
Drug delivery circuit implements the controllable delivery of drug in a manner of ion swimming when range, timely reduces intraocular pressure, it is ensured that patient's eye
Pressure is restored to normal range (NR).Therefore, the invention, which can effectively assist a physician, finds the generation of glaucoma disease early, understands disease
The development of feelings simultaneously makes accurate condition-inference, and the detection because of glaucoma, diagnosis is avoided to be limited by when and where to wrong
Best occasion for the treatment is lost, and realizes timely, efficient, accurate drug delivery simultaneously, improves the prevention and control and treatment ability of medicine of glaucoma.
2, the configuration design of glaucoma detection of eyeball tension system of the present invention, the flexible intelligent contact lens can
It to combine with dioptric technology, go back glaucoma detection of eyeball tension system can not only with the platform of diagnosis of glaucoma and treatment simultaneously
Can have the function of vision correction.
3, glaucoma detection of eyeball tension system of the present invention, with portable, smaller to Ocular irritation, diagnosing and treating is green
Light eye not by place and time restriction, utilization ratio of drug is high the features such as.
Detailed description of the invention
The present invention is described in detail in the following with reference to the drawings and specific embodiments:
Fig. 1 is glaucoma intraocular pressure continuous detecting system structural schematic diagram of the present invention (removal eye medicinal)；
Fig. 2 is glaucoma intraocular pressure continuous detecting system structural schematic diagram (having eye medicinal) of the present invention；
Fig. 3 is single-chip microcontroller and detection of eyeball tension antenna, drug delivery antenna side structure schematic diagram in the present invention；
Fig. 4 is detection of eyeball tension antenna in the present invention, drug delivery antenna face structural schematic diagram；
Fig. 5 is the circuit theory schematic diagram of glaucoma intraocular pressure continuous detecting system of the present invention；
Fig. 6 is the detection method schematic diagram of glaucoma intraocular pressure continuous detecting system of the present invention；
Fig. 7 is the relation schematic diagram of intraocular pressure fluctuation information and frequency of oscillation.
Specific embodiment
As shown in Figures 1 to 6, glaucoma intraocular pressure continuous detecting system of the present invention, including contact lens 10, it is described
It is integrated with detection of eyeball tension circuit 20 in contact lens 10, includes the delivery electricity for treating the hydrogel 60 of glaucoma medicine
Road 30, the detection of eyeball tension circuit 20, drug delivery circuit 30 are wirelessly connect with single-chip microcontroller 40.
The detection of eyeball tension circuit 20 is for detecting intraocular pressure information and wirelessly transmitting through detection of eyeball tension antenna 50
To single-chip microcontroller 40, single-chip microcontroller 40 judges the height of intraocular pressure according to the information received.When intraocular pressure is higher than 21mmHg, single-chip microcontroller 40
It is that drug delivery circuit 30 carries out wireless power, and is supplied after being rectified by drug delivery circuit 30 by drug delivery antenna 31
Electric energy promotes electrically charged glaucoma (timolol, pilocarpine) by angle in the form of constant potential or electric current
Film penetrates into eyes anterior chamber.
The detection of eyeball tension circuit 20 is connected by inductance coil L1 with the capacitance pressure transducer, C1 that pole plate spacing can be changed
LC resonance circuit is formed, the detection of eyeball tension circuit 20 is wirelessly connect by detection of eyeball tension antenna 50 with single-chip microcontroller 40,
Intraocular pressure information convenient for will test is transmitted to single-chip microcontroller.
The drug delivery circuit 30 includes inductance coil L2, diode D2, definite value capacitor C2 and drug delivery positive electrode
311 and drug delivery negative electrode 312.The inductance coil L2 is coupled with drug delivery antenna 31 realizes wireless power transmission, described
Drug delivery circuit 30 is equipped with positive electrode 311 and negative electrode 312, and packet is coated on the positive electrode 311 of drug delivery circuit 30
Contain the pharmaceutical hydrogel 60 for treating glaucoma medicine.
In the present invention, the raising of glaucoma patient intraocular pressure can cause capacitance pressure transducer, C1Pole plate spacing become
It is small, lead to capacitance pressure transducer, C1Capacitance increase, and then cause being total to for the i.e. detection of eyeball tension circuit 20 of LC resonance circuit
Vibration frequency reduces.As shown in figure 5, the variation of resonant frequency of detection of eyeball tension circuit is wirelessly transmitted through detection of eyeball tension antenna 50
To single-chip microcontroller 40.Single-chip microcontroller 40 makes comparisons the intraocular pressure data measured with 21mmHg, if intraocular pressure is higher than 21mmHg, (mankind are normal
Intraocular pressure range is 5mmHg~20mmHg), single-chip microcontroller 40 is medicine by the alternating electric field that drug delivery antenna 31 applies specific frequency
Object delivers circuit 30 and carries out wireless power, the inductance coil L in drug delivery circuit 302The electric energy that induction generates passes through diode
D2 rectification, definite value capacitor C2Promote electrically charged glaucoma (thiophene after filtering in the form of constant potential or electric current
Luo Er, pilocarpine) enter eyes anterior chamber by corneal osmosis.
The contact lens 10 is flexible contact mirror, and material is dimethyl silicone polymer (PDMS), polymethyl
Acid -2- hydroxyl ethyl ester (pHEMA), silicone-hydrogel (SiH), polyethylene terephthalate (PET), Parylene or polyurethane
(TPU), configuration design can be combined with dioptric technology.
The invention also discloses the detection methods of the glaucoma intraocular pressure continuous detecting system, comprise the concrete steps that (such as
Shown in Fig. 6):
S1: the capacitance pressure transducer, C1 by detecting intraocular pressure detects intraocular pressure and the variation of lasting monitoring intraocular pressure, leads to
The variation of intraocular pressure is crossed so that the capacitor plate spacing of capacitance pressure transducer, C1 changes, so as to cause capacitance variation,
And then cause the LC resonance circuit i.e. variation of resonant frequency of detection of eyeball tension circuit, one mechanical signal of intraocular pressure is changed into electricity letter
Number；
S2: it when resonant frequency of the ac frequency of the detection of eyeball tension antenna close to detection of eyeball tension circuit 20, can send out
Raw resonance,
S3: the resonant frequency of detection of eyeball tension circuit 20 is wirelessly transferred to single-chip microcontroller through detection of eyeball tension antenna 50
40；
S4/S5: by scanning the resonant frequency of intraocular pressure sensor, so that varieties of intraocular pressure information is obtained, when intraocular pressure is higher than most
When Low threshold 21mmHg, single-chip microcontroller 40 controls drug delivery antenna 31 and applies certain frequency: the alternating electric field of 10MHz~15MHz
Wireless power is carried out for the drug delivery circuit 30 in contact lens 10；
S6: the inductance coil L in drug delivery circuit 302The electric energy that induction generates passes through diode D2 rectification, definite value electricity
Promote electrically charged glaucoma (timolol, pilocarpine) in the form of constant potential or electric current after holding C2 filtering
Enter eyes anterior chamber by corneal osmosis, i.e. electric field driven drug enters eyes anterior chamber, realizes drug delivery to treat glaucoma.
It is 10MHz~15MHz that single-chip microcontroller 40, which controls drug delivery antenna 31 to apply the certain frequency of alternating electric field, certain frequency
The alternating current of rate makes drug delivery antenna generate alternating electromagnetic field to make the inductance coil L2 in drug delivery circuit 30 generate
Induced electromotive force, the inductance coil L2 in drug delivery circuit 30, which generates induced electromotive force, becomes direct current after diode D2 rectification
Electric forming electric field.The drugs such as the pilocarpine in PVA hydrogel are detached from PVA hydrogel under the driving of electric field, and penetrate cornea
Into the trabecular network of eye anterior chamber, aqueous humor is promoted to reserve channel smooth to reduce intraocular pressure.
As aqueous humor is gradually flowed out from eye anterior chamber, intraocular pressure is gradually decreased.Capacitive pressure in detection of eyeball tension circuit 20
Under the action of the pressure gradually weakened, capacitor two-plate is gradually restored by compressive state to normal shape the capacitor of sensor C1
The two poles of the earth plate spacing of state, capacitor is gradually increased, and is gradually reduced capacitance, and the frequency of oscillation of detection of eyeball tension circuit 20 is caused to be restored
To normal condition.Restore to normal condition frequency of oscillation through detection of eyeball tension antenna transmission to single-chip microcontroller 40；When intraocular pressure is restored to
When normal range (NR), single-chip microcontroller no longer provides excitation for drug delivery antenna, and drug delivery circuit 30 is no longer in PVA hydrogel
Pilocarpine drug provides electric field, and the girder network recovery of eyes anterior chamber is so recycled to normal condition.
It is all that the present invention is not departed to various changes or modifications of the invention the invention is not limited to above embodiment
Spirit and scope, if these modification and variations belong within the scope of claim and equivalent technologies of the invention, then this hair
It is bright to also imply that comprising these modification and variations.
Claims (9)
1. glaucoma intraocular pressure continuous detecting system, it is characterised in that: including contact lens, be integrated in the contact lens
Detection of eyeball tension circuit includes drug delivery circuit for treating glaucoma medicine, the detection of eyeball tension circuit, drug delivery
Circuit is wirelessly connect with the single-chip microcontroller outside contact lens, and the detection of eyeball tension circuit is for detecting intraocular pressure letter
It ceases and is wirelessly transferred to single-chip microcontroller after carrying out signal conversion, single-chip microcontroller judges the height of intraocular pressure according to the information received
Low, when intraocular pressure is higher than normal range (NR), single-chip microcontroller is that drug delivery circuit carries out wireless power, and it is whole to pass through drug delivery circuit
After stream carried out in the form of constant potential or electric current for electric energy before driving pilocarpine drug molecule enters eye through cornea
Drug delivery is realized at room position.
2. glaucoma intraocular pressure continuous detecting system according to claim 1, it is characterised in that: the detection of eyeball tension circuit by
Inductance coil L1 connects to form LC resonance circuit with the capacitor C1 that pole plate spacing can be changed, and the detection of eyeball tension circuit is examined by intraocular pressure
Observation line is connect with single-chip microcontroller, and the wireless transmission for realizing intraocular pressure signal is coupled with detection of eyeball tension antenna.
3. glaucoma intraocular pressure continuous detecting system according to claim 2, it is characterised in that: the drug delivery circuit packet
Inductance coil L2, diode D2 and definite value capacitor C2 are included, it is wireless defeated that the inductance coil L2 couples realization with drug delivery antenna
Electricity, the drug delivery circuit are equipped with positive electrode and negative electrode, and coating is comprising useful on the positive electrode of drug delivery circuit
In the hydrogel for the treatment of glaucoma medicine.
4. glaucoma intraocular pressure continuous detecting system according to claim 3, it is characterised in that: the detection of eyeball tension circuit energy
Enough continuous intraocular pressure signals that detects intraocular pressure and will test wirelessly pass through detection of eyeball tension antenna transmission to single-chip microcontroller, list
Piece machine carries out the judgement of intraocular pressure height according to the intraocular pressure information of acquisition, when the intraocular pressure value detected is higher than minimum intraocular pressure threshold value,
The alternating electric field that single-chip microcontroller controls drug delivery antenna application specific frequency is coupled with the drug delivery circuit in contact lens,
Wireless power is carried out, which is 21mmHg.
5. glaucoma intraocular pressure continuous detecting system according to claim 1, it is characterised in that: the contact lens is soft
Property contact lense, material be dimethyl silicone polymer (PDMS), polymethylacrylic acid -2- hydroxyl ethyl ester (pHEMA), silicone-hydrogel
(SiH), polyethylene terephthalate (PET), Parylene or polyurethane (TPU), configuration design can be with dioptric technologies
It combines.
6. glaucoma intraocular pressure continuous detecting system according to claim 1, it is characterised in that: the eye medicinal is a Shandong
Card product drug or timolol.
7. the detection method of glaucoma intraocular pressure continuous detecting system according to any one of claims 1 to 6, specific steps
It is:
(1) intraocular pressure is detected and the variation of lasting monitoring intraocular pressure by the capacitance pressure transducer, of detection intraocular pressure；
(2) by the variation of intraocular pressure so that the capacitor plate spacing of capacitance pressure transducer, changes, so as to cause capacitor
Value variation, and then cause the variation of resonant frequency of detection of eyeball tension circuit, this mechanical signal of intraocular pressure is changed into electrical signal；
(3) when resonant frequency of the ac frequency of the detection of eyeball tension antenna close to detection of eyeball tension circuit, it may occur that resonance,
To which the resonant frequency of detection of eyeball tension circuit is wirelessly passed through detection of eyeball tension antenna transmission to single-chip microcontroller；
(4) by the resonant frequency of scanning intraocular pressure sensor, to obtain varieties of intraocular pressure information；Single-chip microcontroller believes the intraocular pressure of acquisition
Breath is judged that, when intraocular pressure is higher than lowest threshold, single-chip microcontroller controls the alternating electric field that drug delivery antenna applies certain frequency
It is that the drug delivery circuit in contact lens carries out wireless power with the drug delivery circuit coupling in contact lens；
(5) with constant potential or electric current after the electric energy that the inductance coil L2 in drug delivery circuit is obtained is rectified by diode D2
Form driving hydrogel in pilocarpine drug molecule enter eye anterior chamber position through cornea, realize drug delivery to control
Treat glaucoma.
8. the detection method of glaucoma intraocular pressure continuous detecting system according to claim 7, it is characterised in that: above-mentioned steps
(4) in, the threshold value of intraocular pressure is 21mmHg, and when intraocular pressure is higher than 21mmHg, single-chip microcontroller controls drug delivery antenna and applies certain frequency
Alternating electric field be drug delivery circuit carry out wireless power.
9. the detection method of glaucoma intraocular pressure continuous detecting system according to claim 6, it is characterised in that: above-mentioned steps
(4) in, it is 10MHz~15MHz that single-chip microcontroller, which controls drug delivery antenna to apply the certain frequency of alternating electric field,.
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| CN115381393A (en) * | 2022-09-01 | 2022-11-25 | 北京航空航天大学 | Intraocular pressure measuring method and device based on equal thickness interference |
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