CN108094452A - 一种用于手术室的消毒组合物及其制备工艺 - Google Patents

一种用于手术室的消毒组合物及其制备工艺 Download PDF

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CN108094452A
CN108094452A CN201711436350.2A CN201711436350A CN108094452A CN 108094452 A CN108094452 A CN 108094452A CN 201711436350 A CN201711436350 A CN 201711436350A CN 108094452 A CN108094452 A CN 108094452A
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庞庆华
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Abstract

本发明公开一种用于手术室的消毒组合物及其制备工艺，该消毒组合物由以下份的原料加工而成：厚朴3‑5份、金银花0.5‑2份、知母1‑4份、石苇2‑3份、大戟0.5‑1份、桑寄生0.5‑1份、蚤休2‑4份、茜草2‑6份、红藤1‑2份、大青叶5‑7份、黄药子1‑2份、麻黄1.5‑3份、泽泻12‑17份、羌活0.5‑1份以及茵陈1‑6份，在制作消毒组合物时，通过对原料进行粉碎，提高提取效率与提取率，使原料得到充分的利用。本发明所提供的一种用于手术室的消毒组合物及其制备工艺，该消毒组合物生产方式简单，生产原料简单，使用效果明显，本发明无色且没有明显的中药气味，在使用后很快就会散去乙醇气味，使用后不会对手术室环境造成影响。

Description

一种用于手术室的消毒组合物及其制备工艺
技术领域
本发明属于临床医学护理领域，具体的，涉及一种用于手术室的消毒组合物及其制备工艺。
背景技术
日常生活中的消毒剂主要为84液之类的消毒洁净产品，这些产品也得到了广泛的应用，但是这一类产品一般都含有大量的合成化学物质，且具有较为浓重的刺激味道，并不适用于手术室。
手术室是病人做手术的地方，在对手术室进行消毒时需要满足两个条件，即具有良好的消毒效果和没有刺激性气味，如果消毒剂具有难以消除的刺激性气味，一方面会对医生的状态造成影响，一方面也会对病患的状态造成影响，在手术室中，主要的致病致感染菌为金黄色葡萄球菌与白色念珠菌，如果能够有效的处理这两种病菌，并不产生难以清除的刺激性气味，对于手术室的消毒具有十分显著的意义，对此，本发明提供了以下技术方案。
发明内容
本发明的目的在于提供一种用于手术室的消毒组合物及其制备工艺。
本发明的目的可以通过以下技术方案实现：
一种用于手术室的消毒组合物，由以下原料加工制取：
厚朴、金银花、知母、石苇、大戟、桑寄生、蚤休、茜草、红藤、大青叶、黄药子、麻黄、泽泻、羌活以及茵陈。
具体的，由以下份的原料加工制取：厚朴3-5份、金银花0.5-2份、知母1-4份、石苇2-3份、大戟0.5-1份、桑寄生0.5-1份、蚤休2-4份、茜草2-6 份、红藤1-2份、大青叶5-7份、黄药子1-2份、麻黄1.5-3份、泽泻12-17 份、羌活0.5-1份以及茵陈1-6份。
一种用于手术室的消毒组合物的制备工艺，包括如下步骤：
(1)按照份称取厚朴、金银花、知母、石苇、大戟、桑寄生、蚤休、茜草、红藤、大青叶、黄药子、麻黄、泽泻、羌活以及茵陈，洗净后烘干除去清洗时所吸收的水分，利用粉碎机将原料进行粉碎，得到混合粉料；
(2)在上步骤中所得到的混合粉料加入无水乙醇，在79-85℃的条件下回流 2-3h，得到提取液；
(3)步骤(2)中所得到的提取液冷却过滤，除去杂质，进一步浓缩至体积为原无水乙醇添加量的1/3-1/2，在浓缩的提取液中加入活性炭，吸收提取液中的色素以及中药所特有的味道，得到无色且无明显气味的成品消毒组合物。
进一步的，所述步骤(2)中无水乙醇加入量为混合粉料未挤压状态时体积的 3-5倍。
本发明的有益效果：本发明所提供的一种用于手术室的消毒组合物及其制备工艺，该消毒组合物生产方式简单，生产原料简单，使用效果明显，本发明无色且没有明显的中药气味，在使用后很快就会散去乙醇气味，使用后不会对手术室环境造成影响。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其它实施例，都属于本发明保护的范围。
实施例1：
一种用于手术室的消毒组合物，由以下原料加工制取：
厚朴、金银花、知母、石苇、大戟、桑寄生、蚤休、茜草、红藤、大青叶、黄药子、麻黄、泽泻、羌活以及茵陈。
具体的，由以下份的原料加工制取：厚朴3份、金银花0.5份、知母2份、石苇2份、大戟1份、桑寄生1份、蚤休2份、茜草4份、红藤2份、大青叶7 份、黄药子1-2份、麻黄2份、泽泻14份、羌活1份以及茵陈3份。
一种用于手术室的消毒组合物的制备工艺，包括如下步骤：
(1)按照份称取厚朴、金银花、知母、石苇、大戟、桑寄生、蚤休、茜草、红藤、大青叶、黄药子、麻黄、泽泻、羌活以及茵陈，洗净后烘干除去清洗时所吸收的水分，利用粉碎机将原料进行粉碎，得到混合粉料；
(2)在上步骤中所得到的混合粉料加入无水乙醇，在80℃的条件下回流 2.5h，得到提取液；
(3)步骤(2)中所得到的提取液冷却过滤，除去杂质，进一步浓缩至体积为原无水乙醇添加量的1/3，在浓缩的提取液中加入活性炭，吸收提取液中的色素以及中药所特有的味道，得到无色且无明显气味的成品消毒组合物。
进一步的，所述步骤(2)中无水乙醇加入量为混合粉料未挤压状态时体积的 5倍。
实施例2：
一种用于手术室的消毒组合物，由以下原料加工制取：
厚朴、金银花、知母、石苇、大戟、桑寄生、蚤休、茜草、红藤、大青叶、黄药子、麻黄、泽泻、羌活以及茵陈。
具体的，由以下份的原料加工制取：厚朴4份、金银花1.5份、知母3份、石苇2份、大戟1份、桑寄生1份、蚤休3份、茜草6份、红藤2份、大青叶5 份、黄药子1份、麻黄2份、泽泻13份、羌活0.5份以及茵陈2份。
一种用于手术室的消毒组合物的制备工艺，包括如下步骤：
(1)按照份称取厚朴、金银花、知母、石苇、大戟、桑寄生、蚤休、茜草、红藤、大青叶、黄药子、麻黄、泽泻、羌活以及茵陈，洗净后烘干除去清洗时所吸收的水分，利用粉碎机将原料进行粉碎，得到混合粉料；
(2)在上步骤中所得到的混合粉料加入无水乙醇，在79℃的条件下回流3h，得到提取液；
(3)步骤(2)中所得到的提取液冷却过滤，除去杂质，进一步浓缩至体积为原无水乙醇添加量的1/2，在浓缩的提取液中加入活性炭，吸收提取液中的色素以及中药所特有的味道，得到无色且无明显气味的成品消毒组合物。
进一步的，所述步骤(2)中无水乙醇加入量为混合粉料未挤压状态时体积的 3倍。
实验例：抑菌试验
采用本领域中经典的滤纸片法进行试验，其中：
1.1供试菌种
金黄色葡萄球菌(Staphylococcus aureus)ATCC25923以及白色念珠菌 (Candidaalbicans)ATCC12228,均购自上海谷研实业有限公司。
1.2培养基
营养琼脂培养基，购自上海疾控生物科技有限公司。
1.3试验方法
将金黄色葡萄球菌(Staphylococcus aureus)与白色念珠菌(Candida albicans)均匀接种于营养琼脂培养基的平面上，镊取无菌圆形滤纸片，将实施例1中所制取的消毒组合物均匀喷洒在无菌圆形滤纸片的表面，将滤纸片均匀贴在接种的营养琼脂培养基的表面上，将营养琼脂培养基置于培养箱中，在37℃的条件下温育24h，每8h测定一次金黄色葡萄球菌与白色念珠菌的抑菌环直径大小，计算其平均值。
1.4试验结果
金黄色葡萄球菌的抑菌环的平均直径为10.77mm，白色念珠菌的抑菌环的平均直径为9.02mm，因此，本发明所述的消毒组合物具有明显的消毒效果。
以上公开的本发明优选实施例只是用于帮助阐述本发明。优选实施例并没有详尽叙述所有的细节，也不限制该发明仅为所述的具体实施方式。显然，根据本说明书的内容，可作很多的修改和变化。本说明书选取并具体描述这些实施例，是为了更好地解释本发明的原理和实际应用，从而使所属技术领域技术人员能很好地理解和利用本发明。本发明仅受权利要求书及其全部范围和等效物的限制。

Claims (3)

1.一种用于手术室的消毒组合物，其特征在于，由以下份的原料加工制取：厚朴3-5份、金银花0.5-2份、知母1-4份、石苇2-3份、大戟0.5-1份、桑寄生0.5-1份、蚤休2-4份、茜草2-6份、红藤1-2份、大青叶5-7份、黄药子1-2份、麻黄1.5-3份、泽泻12-17份、羌活0.5-1份以及茵陈1-6份。
2.一种用于手术室的消毒组合物的制备工艺，其特征在于，包括如下步骤：
(1)按照份称取厚朴、金银花、知母、石苇、大戟、桑寄生、蚤休、茜草、红藤、大青叶、黄药子、麻黄、泽泻、羌活以及茵陈，洗净后烘干除去清洗时所吸收的水分，利用粉碎机将原料进行粉碎，得到混合粉料；
(2)在上步骤中所得到的混合粉料加入无水乙醇，在79-85℃的条件下回流2-3h，得到提取液；
(3)步骤(2)中所得到的提取液冷却过滤，除去杂质，进一步浓缩至体积为原无水乙醇添加量的1/3-1/2，在浓缩的提取液中加入活性炭，吸收提取液中的色素以及中药所特有的味道，得到无色且无明显气味的成品消毒组合物。
3.根据权利要求2所述的一种用于手术室的消毒组合物的制备工艺，其特征在于，所述步骤(2)中无水乙醇加入量为混合粉料未挤压状态时体积的3-5倍。
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