CN1080861A - " Naoxuetong " oral liquor and preparation method thereof - Google Patents
" Naoxuetong " oral liquor and preparation method thereof Download PDFInfo
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- CN1080861A CN1080861A CN 93106418 CN93106418A CN1080861A CN 1080861 A CN1080861 A CN 1080861A CN 93106418 CN93106418 CN 93106418 CN 93106418 A CN93106418 A CN 93106418A CN 1080861 A CN1080861 A CN 1080861A
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Abstract
The invention discloses a kind of Chinese patent medicine " " Naoxuetong " oral liquor " for the treatment of acute cerebrovascular disease, it contains Hirudo, the Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae.
Description
The invention discloses a kind of oral liquid for the treatment of acute cerebrovascular disease and preparation method thereof, medicine of the present invention is that feedstock production becomes Chinese medicine liquor with the Chinese herbal medicine, belongs to field of traditional Chinese.
Acute cerebrovascular disease claims apoplexy again, is common ailment of middle-aged and old, frequently-occurring disease.Its sickness rate and mortality rate are in rising trend in recent years, and between twenty and fifty even more noteworthy people is also not rare.Being the very high disease of a kind of mortality rate, also is to cause one of principal disease that the mankind cause death, disable.Mortality rate is 36.2～46.7%, is one of the world's three big dead diseases.China has millions of people to suffer from cerebrovascular every year, has 840,000 people sick dead because of suffering from this.
The medicament categories that is used for the treatment of acute cerebrovascular disease in the prior art is various, and its prescription and effect have nothing in common with each other.For example CN1058535A number application discloses a kind of cerebral embolism ablation capsule, it is to be raw material with Hirudo, Radix Curcumae, Radix Salviae Miltiorrhizae, Tabanus, Olibanum, Myrrha, Semen Persicae, the Radix Astragali, Rhizoma Chuanxiong, Fructus Crataegi, Eupolyphaga Seu Steleophaga, Flos Carthami, sodium salicylate, make capsule, be used for the treatment of cerebral thrombosis, cerebral hemorrhage.But this pharmaceutical formulation complexity, medication is various, and curative effect is difficult to determine.CN1053007A number application discloses a kind of preparation method of embolism dissolving capsule containing pallas pit viper venin.This medicine is to do with Serpentis, and animal and plant medical materials such as Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Astragali, Pheretima, Radix Puerariae, snake venom are raw material, make capsule through specific processing method.Because this pharmaceutical formulation medication is more, the processing step relative complex, and need to take respectively by principal agent and accessory drugs, its limitation is also arranged in actual applications.Make troubles to treatment.
The present invention, has invented " " Naoxuetong " oral liquor " through clinical experimental study for many years according to the understanding of the traditional Chinese medical science to acute cerebrovascular disease.
Medicine of the present invention selects medicine on the basis of existing technology meticulously, and reasonable compatibility reaches best therapeutic effect by less drug dose as far as possible.And consider that dosage form will be happy to be accepted by patient, be developed into product of the present invention.
Therefore, the present invention seeks to the acute cerebrovascular patient provides a kind of curative effect reliable the medicine that toxic and side effects is little.
The crude drug of medicine of the present invention consists of:
Hirudo 250-350 gram Radix Salviae Miltiorrhizae 80-150 gram
Rhizoma Chuanxiong 80-150 gram Radix Angelicae Sinensis 80-150 gram
Radix Astragali 30-80 gram
The optimum amount ratio of the contained effective components of Chinese medicinal of medicine of the present invention is:
Hirudo 300 gram Radix Salviae Miltiorrhizaes 100 grams
Rhizoma Chuanxiong 100 gram Radix Angelicae Sinensis 100 grams
The Radix Astragali 50 grams
Medicine processing technology of the present invention is:
Water intaking trematodiasis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Astragali chopping after being soaked in water 4 hours, decoct with water.Decoct altogether three times, 2 hours for the first time, for the second time, each 1.5 hours for the third time, each amount of water was for surpassing powder 6cm.Collecting decoction, filtration, concentrate, concentrated solution adds ethanol, makes to contain the alcohol amount and reach 70%, fully stirs, and leaves standstill 24 hours, filters filtrate recycling ethanol.Get ethylparaben again and add dissolve with ethanol, add medicinal liquid, cyclamate, essence and distilled water, stir, filter, be distributed into 10 milliliters every bottle.
Through clinical practice treatment intracerebral hematoma 114 examples, 68 examples of fully recovering, produce effects 23 examples, effective 18 examples, total effective rate 95.6%.Treatment ischemic cerebrovascular 376 is cured 213 examples, produce effects 64 examples, effective 89 examples, total effective rate 97.3%.Clinical observation result shows that this product is evident in efficacy, is the medicine of current optimal treatment acute cerebrovascular disease.Medicine of the present invention is especially better to cerebral infarction at restoration stage, sequela patient's effect, has no side effect.
Embodiment:
Prescription: Hirudo 300 gram Radix Salviae Miltiorrhizaes 100 grams
Rhizoma Chuanxiong 100 gram Radix Angelicae Sinensis 100 grams
The Radix Astragali 50 grams
Get Hirudo, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Astragali chopping of prescription dosage, after being soaked in water 4 hours, decoct with water.Decoct altogether three times, 2 hours for the first time, for the second time, each 1.5 hours for the third time, each amount of water was that liquid level surpasses medicine face 6cm, collecting decoction, filter, be concentrated into 100ml, concentrated solution adds 288 milliliters of ethanol, makes to contain the alcohol amount and reach 70%, fully stir, left standstill 24 hours, and filtered filtrate recycling ethanol, get 0.4g the more stupid Ethyl formate of hydroxyl is added the 30ml dissolve with ethanol, add medicinal liquid, add cyclamate 0.1g again, essence 0.5ml, adding distil water is to 1000ml, stir, filter, be distributed into 10 milliliters every bottle.
Claims (4)
1, a kind of oral liquid for the treatment of acute cerebrovascular disease is characterized in that it is made up of following component:
Hirudo 250-350 gram Radix Salviae Miltiorrhizae 80-150 gram
Rhizoma Chuanxiong 80-150 gram Radix Angelicae Sinensis 80-150 gram
Radix Astragali 30-80 gram
2,, it is characterized in that it can also contain ethylparaben 0.4g according to the oral liquid of claim 1.
3,, it is characterized in that it can also contain cyclamate 0.1g, essence 0.5ml according to the oral liquid of claim 1 or 2.
4, a kind of method for preparing claim 1 oral liquid, the Hirudo, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Astragali chopping that it is characterized in that getting prescription dosage are after being soaked in water 4 hours, decoct with water three times, the 1st time 2 hours, for the second time, for the third time each 1.5 hours, each amount of water is that liquid level exceeds medicine 6cm, collecting decoction, filter, be concentrated into 100ml, concentrated solution adds 288 milliliters of ethanol, makes to contain the alcohol amount and reach 70%, fully stir, left standstill 24 hours, and filtered filtrate recycling ethanol.Get the 0.4g ethylparaben again and add the 30ml dissolve with ethanol, add medicinal liquid, add cyclamate 0.1g again, essence 0.5ml, adding distil water stir to 1000ml, filter, and are distributed into 10 milliliters every bottle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93106418A CN1039879C (en) | 1993-06-04 | 1993-06-04 | "Naoxuetong" oral liquor and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93106418A CN1039879C (en) | 1993-06-04 | 1993-06-04 | "Naoxuetong" oral liquor and its preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1080861A true CN1080861A (en) | 1994-01-19 |
| CN1039879C CN1039879C (en) | 1998-09-23 |
Family
ID=4986219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93106418A Expired - Fee Related CN1039879C (en) | 1993-06-04 | 1993-06-04 | "Naoxuetong" oral liquor and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1039879C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1053828C (en) * | 1995-10-20 | 2000-06-28 | 王泰升 | Oral medicine for treating acute cerebrovascular disease |
| CN1062160C (en) * | 1997-01-13 | 2001-02-21 | 李国华 | Drug for curing cerebral infarction |
| CN1067254C (en) * | 1994-11-21 | 2001-06-20 | 于夫 | Traditional Chinese medicine pill "Guan-mai-dan" for curing coronary heart disease and the like |
| CN104547028A (en) * | 2015-01-16 | 2015-04-29 | 袁金海 | Traditional Chinese medicine composition capable of dredging blood vessels and removing plaques |
| CN111184767A (en) * | 2020-01-19 | 2020-05-22 | 张家口义王堂生物科技有限责任公司 | Traditional Chinese medicine composition for promoting blood circulation and removing blood stasis, Sanqing stasis removing pill and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106729101B (en) * | 2017-01-13 | 2020-09-22 | 黑龙江中医药大学 | Traditional Chinese medicine composition for treating post-circulation ischemic stroke and preparation method thereof |
-
1993
- 1993-06-04 CN CN93106418A patent/CN1039879C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1067254C (en) * | 1994-11-21 | 2001-06-20 | 于夫 | Traditional Chinese medicine pill "Guan-mai-dan" for curing coronary heart disease and the like |
| CN1053828C (en) * | 1995-10-20 | 2000-06-28 | 王泰升 | Oral medicine for treating acute cerebrovascular disease |
| CN1062160C (en) * | 1997-01-13 | 2001-02-21 | 李国华 | Drug for curing cerebral infarction |
| CN104547028A (en) * | 2015-01-16 | 2015-04-29 | 袁金海 | Traditional Chinese medicine composition capable of dredging blood vessels and removing plaques |
| CN111184767A (en) * | 2020-01-19 | 2020-05-22 | 张家口义王堂生物科技有限责任公司 | Traditional Chinese medicine composition for promoting blood circulation and removing blood stasis, Sanqing stasis removing pill and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1039879C (en) | 1998-09-23 |
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Legal Events
| Date | Code | Title | Description |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: PLA 66069 ARMY HOSPITAL Free format text: FORMER NAME OR ADDRESS: NIU ZHUQIN |
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| CP03 | Change of name, title or address |
Address after: No. 66069 Dongfeng 63 hospital, Dongfeng Middle Road, Hebei, Baoding Patentee after: 66069 Army Hospital of PLA Address before: The 51036 Army Hospital of Baoding Hebei Province Patentee before: Niu Zhuqin |
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| ASS | Succession or assignment of patent right |
Owner name: SHANDONG SHENGLI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: PLA 66069 ARMY HOSPITAL Effective date: 20021011 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20021011 Address after: 257055 No. two, 142 North Road, Shandong, Dongying Patentee after: Shandong Shengli Pharmaceutical Co., Ltd. Address before: 66069 army hospital, No. 63 Dongfeng Middle Road, Hebei, Baoding 071051, China Patentee before: 66069 Army Hospital of PLA |
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| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 19980923 Termination date: 20120604 |