CN108079131A - Deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed and preparation method thereof - Google Patents
Deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The present invention discloses a kind of deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed and preparation method thereof, the essential oil containing camellia seed deep layer maintenance anti-inflammatory anti-itch kibe ointment, in units of parts by weight, including following raw material：40~60 parts of camellia seed essential oil, 20~30 parts of Japan cypress extract, 8~10 parts of tribulus terrestris, 15~25 parts of willow leaf, 25~35 parts of Herba speranskiae tuberculatae extract, 10~15 parts of saururus chinensis, the invention also discloses the preparation methods of the deep layer of essential oil containing the camellia seed maintenance anti-inflammatory anti-itch kibe ointment, through decoction, concentration, mixing, stirring and etc. be made.The deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed of the present invention can effectively facilitate internal layer cytothesis, nourish sebaceous cell, accelerate to repair and shine pernio wound, anti-inflammatory cutin-softening, incrustation is eliminated, each raw material collective effect plays the role of deep layer maintenance anti-inflammatory anti-itch, analgesic, and cell permeability is preferable, can rapid osmotic take effect, rapid recovery patient suffering.
Description
Technical field
The invention belongs to health care technology fields, and in particular to a kind of deep layer maintenance of essential oil containing camellia seed anti-inflammatory anti-itch freezes
Sore cream and preparation method thereof.
Background technology
Pernio belongs to the abnormal response that cold occurs for body, and modern medicine thinks that pernio is because the skin of patient resists cold
Property it is poor, in addition cold invasion and attack, make the skin vasoconstriction of tip or spasm occurs, cause local blood circulation obstacle so that
Oxygen and subalimentation and the tissue damage occurred.Traditional Chinese medicine thinks that the occurrence of this disease is due to patient's YANG QI deficiency, diseases caused by external factors cold-dampness
Heresy, make QI-blood circulation not smooth, stagnation of blood stasis and fall ill, be easily happened at the immunity of organism decorum such as children, women and the elderly
More fragile, the poor crowd of resisting cold property, and happening part belongs to the tip and naked position of limbs, as hand, foot, nose, in one's ear,
Ear-lobe and Face and cheek, cold season pernio once occur, not only pain but also itch, can also fester when serious, it is agonizing.
Drug currently used for treating pernio has very much, but often treatment time is long, slowly effect, and also pernio forms a scab,
Curative effect is not fully up to expectations.
The content of the invention
The object of the present invention is to provide a kind of deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed and preparation method thereof,
Can deep layer repair Inflammatory Lesions, anti-inflammatory anti-itch, while can also eliminate incrustation is quick, cure rate height.
Purpose to realize the present invention, using following technical scheme：
The deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed, in units of parts by weight, including following raw material：Camellia seed
40~60 parts of essential oil, 20~30 parts of Japan cypress extract, 15~25 parts of willow leaf, 25~35 parts of Herba speranskiae tuberculatae extract, tribulus terrestris 8~10
Part, 10~15 parts of saururus chinensis.
The present invention also provides a kind of preparation method of the deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment, including following
Step：
T1:Tribulus terrestris, saururus chinensis are weighed, tribulus terrestris is added in and 5 times of deionized waters of saururus chinensis gross weight decocts, concentrate, system
Soft extracts is obtained, it is spare；
T2:Japan cypress extract, Herba speranskiae tuberculatae extract is taken to be mixed evenly, adds in camellia seed essential oil, concentration is made 60
DEG C relative density be 1.20%~1.25% clear cream, spare, wherein Japan cypress extract:Herba speranskiae tuberculatae extract:Camellia seed essence
Oily mixed proportion is 1:1:2；
T3:Willow leaf is taken to smash to pieces, adds in alcohol solvent reflux condensation mode, is crystallized, it is dry, white coarse powder is made, it is spare；
T4:Clear cream made from step T2 is taken, white coarse powder, stirring made from step T3 are added according to the 10% of clear cream weight
Uniformly, the relative density being made at 60 DEG C is 1.28~1.32% thick paste；
T5:Take soft extracts made from step T1 with thick paste made from step T4 by 1~1.5:3~4 ratios mix, and stirring is equal
It is even to get the deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed.
Preferably, the weight part ratio of tribulus terrestris and saururus chinensis is 1 in step T1:1.5.
The advantageous effect that the present invention obtains
The deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed of the present invention adds in Japan cypress extract, lopseed extraction
Object, saururus chinensis, have effects that promoting blood circulation, swelling and pain relieving, anti-inflammatory anti-itch, and camellia seed essential oil can effectively facilitate inner-layer thin with tribulus terrestris
Born of the same parents regenerate, nourish sebaceous cell, accelerate repair shine pernio wound, willow leaf alcohol reflux extract can anti-inflammatory cutin-softening, disappear
Except incrustation, each raw material collective effect plays the role of deep layer maintenance anti-inflammatory anti-itch, and cell permeability is preferable, being capable of rapid osmotic
It takes effect, rapid recovery patient suffering.
Specific embodiment
Preferably to explain that the deep layer maintenance anti-inflammatory anti-itch of essential oil containing camellia seed kibe ointment of the invention obtains notable beneficial to effect
Fruit is further illustrated using detailed description below：
One, essential oils containing camellia seed deep layer maintenance anti-inflammatory anti-itch kibe ointment and preparation method thereof
Embodiment 1
The deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed, in units of parts by weight, including following raw material：Camellia seed
40 parts of essential oil, 20 parts of Japan cypress extract, 15 parts of willow leaf, 25 parts of Herba speranskiae tuberculatae extract, 8 parts of tribulus terrestris, 10 parts of saururus chinensis.
The preparation method of the deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed, comprises the following steps：
T1:Tribulus terrestris, saururus chinensis are weighed by weight, add in tribulus terrestris and 5 times of amount deionization decoctings of saururus chinensis gross weight
It boils, concentrates, soft extracts is made, it is spare；
T2:Japan cypress extract, Herba speranskiae tuberculatae extract is taken to be mixed evenly, adds in camellia seed essential oil, concentration is made 60
DEG C relative density be 1.20% clear cream, spare, wherein Japan cypress extract:Herba speranskiae tuberculatae extract:Camellia seed essential oil mixing ratio
Example is 1:1:2；
T3:Willow leaf is taken to smash to pieces, adds in alcohol solvent reflux condensation mode, is crystallized, it is dry, white coarse powder is made, it is spare；
T4:Clear cream made from step T2 is taken, white coarse powder, stirring made from step T3 are added according to the 10% of clear cream weight
Uniformly, the relative density being made at 60 DEG C is 1.28 thick paste；
T5:Take soft extracts made from step T1 with thick paste made from step T4 by 1:3 ratios mix, stir evenly to get containing
Camellia seed essential oil deep layer maintenance anti-inflammatory anti-itch kibe ointment.
Embodiment 2
The deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed, in units of parts by weight, including following raw material：Camellia seed
50 parts of essential oil, 25 parts of Japan cypress extract, 20 parts of willow leaf, 30 parts of Herba speranskiae tuberculatae extract, 10 parts of tribulus terrestris, 15 parts of saururus chinensis.
The preparation method of the deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed, comprises the following steps：
T1:Tribulus terrestris, saururus chinensis are weighed, tribulus terrestris is added in and 5 times of deionized waters of saururus chinensis gross weight decocts, concentrate, system
Soft extracts is obtained, it is spare；
T2:Japan cypress extract, Herba speranskiae tuberculatae extract is taken to be mixed evenly, adds in camellia seed essential oil, concentration is made 60
DEG C relative density be 1.25% clear cream, spare, wherein Japan cypress extract:Herba speranskiae tuberculatae extract:Camellia seed essential oil mixing ratio
Example is 1:1:2；
T3:Willow leaf is taken to smash to pieces, adds in alcohol solvent reflux condensation mode, is crystallized, it is dry, white coarse powder is made, it is spare；
T4:Clear cream made from step T2 is taken, white coarse powder, stirring made from step T3 are added according to the 10% of clear cream weight
Uniformly, the relative density being made at 60 DEG C is 1.32% thick paste；
T5:Take soft extracts made from step T1 with thick paste made from step T4 by 1:3 ratios mix, stir evenly to get containing
Camellia seed essential oil deep layer maintenance anti-inflammatory anti-itch kibe ointment.
Embodiment 3
The deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed, in units of parts by weight, including following raw material：Camellia seed
60 parts of essential oil, 30 parts of Japan cypress extract, 25 parts of willow leaf, 35 parts of Herba speranskiae tuberculatae extract, 10 parts of tribulus terrestris, 12 parts of saururus chinensis.
The present invention also provides a kind of preparation method of the deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment, including following
Step：
T1 is by weight:Tribulus terrestris, saururus chinensis are weighed, tribulus terrestris is added in and 5 times of deionized waters of saururus chinensis gross weight decocts,
Soft extracts is made in concentration, spare；
T2:Japan cypress extract, Herba speranskiae tuberculatae extract is taken to be mixed evenly, adds in camellia seed essential oil, concentration is made 60
DEG C relative density be 1.23% clear cream, spare, wherein Japan cypress extract:Herba speranskiae tuberculatae extract:Camellia seed essential oil mixing ratio
Example is 1:1:2；
T3:Willow leaf is taken to smash to pieces, adds in alcohol solvent reflux condensation mode, is crystallized, it is dry, white coarse powder is made, it is spare；
T4:Clear cream made from step T2 is taken, white coarse powder, stirring made from step T3 are added according to the 10% of clear cream weight
Uniformly, the relative density being made at 60 DEG C is 1.30% thick paste；
T5:Take soft extracts made from step T1 with thick paste made from step T4 by 1.5:4 ratios mix, stir evenly to get
The deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed.
Embodiment 4
The deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed, in units of parts by weight, including following raw material：Camellia seed
45 parts of essential oil, 27 parts of Japan cypress extract, 18 parts of willow leaf, 32 parts of Herba speranskiae tuberculatae extract, 9 parts of tribulus terrestris, 10 parts of saururus chinensis.
The preparation method of the deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed, comprises the following steps：
T1:Tribulus terrestris, saururus chinensis are weighed by weight, add in tribulus terrestris and 5 times of deionized waters of saururus chinensis gross weight decoct,
Soft extracts is made in concentration, spare；
T2:Japan cypress extract, Herba speranskiae tuberculatae extract is taken to be mixed evenly, adds in camellia seed essential oil, concentration is made 60
DEG C relative density be 1.25% clear cream, spare, wherein Japan cypress extract:Herba speranskiae tuberculatae extract:Camellia seed essential oil mixing ratio
Example is 1:1:2；
T3:Willow leaf is taken to smash to pieces, adds in alcohol solvent reflux condensation mode, is crystallized, it is dry, white coarse powder is made, it is spare；
T4:Clear cream made from step T2 is taken, white coarse powder, stirring made from step T3 are added according to the 10% of clear cream weight
Uniformly, the relative density being made at 60 DEG C is 1.32% thick paste；
T5:Take soft extracts made from step T1 with thick paste made from step T4 by 1.2:3.5 ratios mix, and stir evenly, i.e.,
Camellia seed essential oil deep layer maintenance anti-inflammatory anti-itch kibe ointment must be contained.
Comparative example 1
Deep layer maintenance anti-inflammatory anti-itch kibe ointment, including following raw material：22 parts of Japan cypress extract, 18 parts of willow leaf, tribulus terrestris 20
Part, 12 parts of saururus chinensis, 25 parts of Herba speranskiae tuberculatae extract.Preparation process uses the embodiment of the present invention 2.
Comparative example 2
Deep layer maintenance anti-inflammatory anti-itch kibe ointment, including following raw material：45 parts of camellia seed essential oil, 22 parts of Japan cypress extract, thorn
20 parts of puncture vine, 12 parts of saururus chinensis, 35 parts of Herba speranskiae tuberculatae extract.Preparation process is using the present invention
Embodiment 2.
Comparative example 3
The deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed, including following raw material：45 parts of camellia seed essential oil, Japan cypress carry
Take 22 parts of object, 18 parts of willow leaf, 12 parts of saururus chinensis, 30 parts of Herba speranskiae tuberculatae extract.Preparation process uses the embodiment of the present invention 2.
Embodiment 4
Deep layer maintenance anti-inflammatory anti-itch kibe ointment, including following raw material：22 parts of Japan cypress extract, 12 parts of saururus chinensis, lopseed
30 parts of extract.Preparation process uses the embodiment of the present invention 2.
Two, essential oils containing camellia seed deep layer maintenance anti-inflammatory anti-itch kibe ointment application effects are tested
Cardinal symptom includes principle：Affected part redness is itched pain, blister, patch, and is divided into I degree of pernio, II degree of pernio, III degree of jelly
Sore.Wherein I degree of pernio is：Affected part redness is itched bitterly, but without patch, blister；II degree of pernio：Affected part redness is itched bitterly, there is patch, water
Blister but non-ulceration；III degree of pernio：Affected part is itched pain, ulcer, erosion.
Subjects：36 pernio volunteers are invited, test group, control group are set respectively, wherein test group uses this hair
The deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed made from bright embodiment 1-4, control group 1-4 use comparative example 1-4 systems
Anti-inflammatory anti-itch kibe ointment, the control group 5 obtained uses a kind of patent of invention " kibe ointment " (patent No.：ZL103721233A), by
Following components forms：Cassia twig 15-25g, Chinese cassia tree 10-20g, Radix Salviae Miltiorrhizae 5-15g, safflower 5-15g, asarum 5-10g, rhubarb 5-15g,
Root of Dahurain angelica 15-25g, profound Hu 15-25g, sesame oil 200g, application method：Continuous apply is used within first 3 days, then uses every other day, observes 3 respectively
My god, 5 days, 7 days affected part symptoms repair situation.
Result of the test is as follows：
1. compared using the damage of preceding each group experimenter pernio：
1 deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment of subordinate list is compared using the damage of preceding pernio
1 data of table can obtain, using preceding each group pernio damage difference unobvious, without statistical significance.
2. compared using rear each group pernio recovery effects, the results detailed in Table 2：
2 deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment of subordinate list is compared using rear pernio recovery situation
From the data in table 2, it can be seen that using preceding each group pernio damage difference unobvious, but each group uses anti-inflammatory anti-itch pernio
There are significant difference, wherein test group 1-4 that the deep layer maintenance anti-inflammatory of essential oil containing camellia seed is made using the embodiment of the present invention for cream process
After antipruritic kibe ointment, 80% is up to using total effective rate after 7 days, compared with the control group, pernio affected part recovery situation is apparent
Better than control group, total effective rate is only 40% wherein in control group 1, employs anti-inflammatory anti-itch kibe ointment made from comparative example 1,
It is only 28.57% that control group 2, which recovers total effective rate to be only, employs anti-inflammatory anti-itch kibe ointment made from comparative example 2, control group 3
It is only 35.71% to recover total effective rate to be only, and employs anti-inflammatory anti-itch kibe ointment made from comparative example 3, control group 4 recovers always to have
It is only 18.75% that efficiency, which is only, employs anti-inflammatory anti-itch kibe ointment made from comparative example 4, and control group 5 recovers total effective rate and is only
Only 33.33%, employ a kind of patent of invention " kibe ointment " (patent No.：ZL103721233A) product.
The 3 deep layer maintenance anti-inflammatory anti-itch of essential oil containing camellia seed kibe ointment of subordinate list recovers comparison situation
As subordinate list 3 as it can be seen that the deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment made from using the embodiment of the present invention
Test group it is with obvious effects more more stable than control group in the maintenance damaged for different degrees of pernio, and take effect faster, especially
Test group 1, experiment 3 days I degree of pernio patients, 5 recoveries 3, full recovery in 7 days, II degree of pernio patient 7, recovery 4 in 3 days,
III degree of pernio patient 3 recovers 2 in 3 days, and total effective rate reaches 80%.
The raw material of the deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed of the present invention is carried using camellia seed essential oil, Japan cypress
Take object, willow leaf, Herba speranskiae tuberculatae extract, tribulus terrestris, saururus chinensis；
The anti-inflammatory anti-itch kibe ointment raw material that control group 1 uses lacks camellia seed essential oil, uses I degree of pernio patient 5 after 3 days
Only recover 1, only recover within 7 days 2, II degree of pernio patient 7, recovery 1, III degree of pernio patient 3 only recover 2 in 3 days within 3 days
Example, and patient is recurred after being spaced 1 day, total effective rate 40%, slowly effect and unstable, easily recurrence；
The anti-inflammatory anti-itch kibe ointment raw material that control group 2 uses lacks willow leaf, recovers 1 using I degree of pernio patient 8 after 3 days
Example, only recovers 3 for 7 days, and II degree of pernio patient 7 recovers 0, III degree of pernio patient, 1 recovery 0 in 3 days, total effective rate for 3 days
28.57%, slowly effect；
The anti-inflammatory anti-itch kibe ointment raw material that control group 3 uses lacks tribulus terrestris, uses I degree of pernio patient, 6 recoveries after 3 days
0, only recover within 7 days 3, II degree of pernio patient 7 recovers 0, III degree of pernio patient, 1 recovery 0 in 3 days for 3 days, total effective
Rate 35.71%, slowly effect；
The anti-inflammatory anti-itch kibe ointment raw material that control group 4 uses lacks tribulus terrestris, willow leaf, camellia seed essential oil, uses after 3 days I
Spend 6 recoveries 0 of pernio patient, recovery 0 in 7 days, II degree of pernio patient 6,0, III degree of recovery in 3 days pernio patient 33 days
Recover 2, total effective rate is only 18.75%, and significant effect reduces, slowly effect.
Control group 5 uses a kind of patent of invention " kibe ointment " (patent No.：ZL103721233A), by following components group
Into：Cassia twig 15-25g, Chinese cassia tree 10-20g, Radix Salviae Miltiorrhizae 5-15g, safflower 5-15g, asarum 5-10g, rhubarb 5-15g, root of Dahurain angelica 15-
25g, profound Hu 15-25g, sesame oil 200g recover 0 using I degree of pernio patient 5 after 3 days, recover within 7 days 2, II degree of pernio is suffered from
Person 8, recovers 0, III degree of pernio patient, 2 recoveries 1 in 3 days for 3 days, and total effective rate 33.33% is substantially less than containing for the present invention
Camellia seed essential oil deep layer maintenance anti-inflammatory anti-itch kibe ointment.
It can be seen that the deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed of the present invention is extensive to the pernio damaged in various degree
Multiple quick, total effective rate is high, curative effect stability and no relapse.
The above content is combine specific/preferred embodiment further description made for the present invention, it is impossible to
Assert that the specific implementation of the present invention is confined to these explanations.Come for general technical staff of the technical field of the invention
It says, without departing from the inventive concept of the premise, some replacements or modification can also be made to the embodiment that these have been described,
And these are substituted or variant should all be considered as belonging to protection scope of the present invention.
Claims (9)
1. the deep layer maintenance anti-inflammatory anti-itch kibe ointment of essential oil containing camellia seed, which is characterized in that in units of parts by weight, including following original
Material：40~60 parts of camellia seed essential oil, 20~30 parts of Japan cypress extract, 15~25 parts of willow leaf, 25~35 parts of Herba speranskiae tuberculatae extract, thorn
8~10 parts of puncture vine, 10~15 parts of saururus chinensis.
2. a kind of preparation method of the deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment according to claim 1,
It is characterized in that, comprises the following steps：
T1:Tribulus terrestris, saururus chinensis are taken, deionized water mixing is added in and decocts, soft extracts is made in concentration, spare；
T2:Japan cypress extract, Herba speranskiae tuberculatae extract is taken to be mixed evenly, adds in camellia seed essential oil, clear cream is made in concentration, standby
With；
T3:Willow leaf is taken to smash to pieces, adds in alcohol solvent reflux condensation mode, is crystallized, it is dry, white coarse powder is made, it is spare；
T4:Clear cream made from step T2 is taken, white coarse powder made from step T3 is added in, stirs evenly, thick paste is made；
T5:Soft extracts made from step T1 is taken to be mixed with thick paste made from step T4, stir evenly to get.
3. the preparation method of the deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment according to claim 2, feature
It is, the addition of deionized water described in step T1 is tribulus terrestris and 5 times of amounts of saururus chinensis gross weight.
4. the preparation method of the deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment according to claim 2, feature
It is, tribulus terrestris described in step T1:The weight ratio of saururus chinensis is 1:1.5.
5. the preparation method of the deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment according to claim 2, feature
It is, Japan cypress extract in step T2:Herba speranskiae tuberculatae extract:Camellia seed essential oil mixed proportion is 1:1:2.
6. the preparation method of the deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment according to claim 2, feature
It is, clear cream obtained is 1.20%~1.25% in 60 DEG C of relative density in step T2.
7. the preparation method of the deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment according to claim 2, feature
It is, white coarse powder addition is the 10% of clear cream weight described in step T4.
8. the preparation method of the deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment according to claim 2, feature
It is, the thick paste described in step T4 is 1.28~1.32% in 60 DEG C of relative density.
9. the preparation method of the deep layer of essential oil containing camellia seed maintenance anti-inflammatory anti-itch kibe ointment according to claim 2, feature
It is, soft extracts described in step T5 is 1~1.5 with thick paste mixed proportion:3~4.
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| CN104547180A (en) * | 2014-12-29 | 2015-04-29 | 西宁意格知识产权咨询服务有限公司 | Cream for treating chilblain and preparation method for cream |
| CN106334176A (en) * | 2016-10-21 | 2017-01-18 | 皖南医学院 | Chilblain cream capable of relieving swelling, pain and itching and preparation method thereof |
| CN107519317A (en) * | 2017-08-29 | 2017-12-29 | 宁波保税区攀峒信息科技有限公司 | A kind of Chinese herbal and crude drugs preparations for alleviating skin symptom |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547180A (en) * | 2014-12-29 | 2015-04-29 | 西宁意格知识产权咨询服务有限公司 | Cream for treating chilblain and preparation method for cream |
| CN106334176A (en) * | 2016-10-21 | 2017-01-18 | 皖南医学院 | Chilblain cream capable of relieving swelling, pain and itching and preparation method thereof |
| CN107519317A (en) * | 2017-08-29 | 2017-12-29 | 宁波保税区攀峒信息科技有限公司 | A kind of Chinese herbal and crude drugs preparations for alleviating skin symptom |
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Application publication date: 20180529 |