CN108079088A - A kind of oral liquid for preventing domestic animal laryngitis - Google Patents
A kind of oral liquid for preventing domestic animal laryngitis Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a kind of oral liquids for preventing domestic animal laryngitis, are related to animal health-care product technical field, are made of following component：Ammonification Chinese Drug Gualouzi, oligoisomaltose, zinc gluconate, peppermint, motherwort, semen armeniacae amarae, summer be withered, humulus grass treatment fluid, water；Compared with prior art, the present invention prepare prevention domestic animal laryngitis oral liquid, can not only effectively preventing domestic animal laryngitis, meanwhile, it is capable to prevent domestic animal, poultry infection bird flu.
Description
Technical field
The invention belongs to animal health-care product technical fields, and in particular to a kind of oral liquid for preventing domestic animal laryngitis.
Background technology
Laryngitis is the inflammation of larynx mucous membrane, causes a kind of upper respiratory disease that acutely cough and larynx sensitivity are characterized.
Various animals may occur.Laryngitis takes place mostly in the infection of the upper respiratory tract caused by flu of catching cold, sucking dust, smog or thorn
Swashing the stimulations such as property gas and foreign matter can fall ill.Be mainly shown as violent cough, disease just to be dry and the cough of pain, sound are very brief
It is powerful, then become wet and long cough, the hoarseness when course of disease is longer later.Present clinical is mostly used powder treatment, market medication
Single, dosage form is simple, is not easy to take, and urgently field energy release in city's can more preferably promote the oral liquid formulation of drug absorption to raiser.
The content of the invention
The purpose of the present invention is being directed to the problem of existing, a kind of oral liquid for preventing domestic animal laryngitis is provided.
The present invention is achieved by the following technical solutions：
A kind of oral liquid for preventing domestic animal laryngitis, is made by weight of following component：It is ammonification Chinese Drug Gualouzi 15-20, oligomeric different
Maltose 0.3-0.5, zinc gluconate 0.1-0.4, peppermint 10-12, motherwort 6-8, semen armeniacae amarae 2-4, summer withered 3-6, at humulus grass
Manage liquid 30-50, water 150-200；
The humulus grass handles liquid and preparation method thereof：It by humulus grass drying, crushes, obtains 100 mesh powder, ethyl alcohol and humulus grass powder are pressed
5:1 mass ratio mixing, when refluxing extraction 3 is small, filtering obtains extracting solution, heating recovery ethyl alcohol, and extracting solution is concentrated to dryness, obtains
Solid content；Obtained solid content and salt, sodium glutamate, water are pressed 1：0.8：0.2：50 weight ratio mixing, is heated to 80
DEG C, 40min is stirred with the rate of 1500r/min, cooled to room temperature is to get humulus grass treatment fluid.
Further, the ammonification Chinese Drug Gualouzi preparation method is：Chinese Drug Gualouzi is smashed it through into 120 mesh sieves, then sprinkling is mixed
Conjunction microbial inoculum, which is placed in vacuum tank, carries out cold fermentation, then adds in ammonification microbial inoculum and carries out ammoniated treatment, and vacuum pressure tank is 8kPa,
Temperature is 40 DEG C, time 35min；The ammonification microbial inoculum is by hay bacillus：Rhizopus oryzae presses 3:1 mass ratio mixes；Described
Cold fermentation, 10 DEG C of fermentation temperature, when fermentation time 3 is small；The mix bacterium agent presses 5 for aspergillus oryzae and saccharomycete:2 mass
Ratio is mixed.
Further, the oral liquor of the prevention domestic animal laryngitis is：
（1）By weight by ammonification Chinese Drug Gualouzi, peppermint, motherwort, semen armeniacae amarae, summer withered uniform mixing, 100 parts by weight are then added
Water, be heated to seething with excitement, keep the temperature 15min, then adjust the temperature to 60 DEG C, when heat preservation 2 is small, it is residual to be then filtered removal solid
Slag obtains filtrate；
（2）Oligoisomaltose and zinc gluconate are dissolved in remaining water, mixed liquor is made, is kept the temperature at 10 DEG C；
（3）First by step（1）In filtrate mixed with humulus grass treatment fluid, be heated to 40 DEG C, with 150r/min rotating speeds stir
Then 20min adjusts the temperature to 10 DEG C, keep the temperature 15min, then add step（2）The mixed liquor of middle preparation, after stirring evenly, warp
Cross ultrasonication 5min, then proceed to heat preservation 1 it is small when, then clear-cutting forestland to room temperature to get.
Further, the step（3）Middle ultrasonic power is 800W, frequency 65kHz.
The oral liquid of present invention prevention domestic animal laryngitis is pressed 0.01:100 ratio uniform is scattered in drinking-water, allows domestic animal certainly
By drinking；0.025 is pressed when domestic animal falls ill:100 ratio uniform is scattered in drinking-water, and domestic animal is allowed freely to drink.
The present invention has the following advantages compared with prior art：Compared with prior art, the prevention domestic animal larynx that prepared by the present invention
Scorching oral liquid, can not only effectively preventing domestic animal laryngitis, meanwhile, it is capable to prevent domestic animal, poultry infection bird flu.It is beneficial female
Grass, semen armeniacae amarae, summer withered collaboration compatibility effect, can reach clearing heat and detoxicating, wind-heat dissipating, dispersing swelling and dissipating binds, removing toxic substances, preventing phlegm from forming and stopping coughing,
Clearing away damp-heat, removing pattogenic heat from the blood and toxic material from the body, the sharp larynx of detumescence, damp and hot malicious spot, hepatic cholagogic, the endotoxic effect of cleaning, by using ammonification Snakegourd Fruit
The synergistic effect of son and humulus grass treatment fluid, can be antiviral, antibacterium, heat-clearing and toxin-vanquishing, removing heat from the liver, antibiotic and sterilizing, improves disease-resistant
Ability prevents Virus entry host cell, inhibits the synthesis of its DNA and RNA, inhibits viral growth breeding and plays antiviral
Effect, and with removing toxic substances, improve immunity of organisms the effect of, add a certain amount of peppermint can further improve resisting stress,
It improves immunity of organisms, disease resistance, promote blood circulation, and mouthfeel can be improved, there is quick, curative effect really, without medicine
The characteristics of residual, without any side effects.It can accomplish to treat both principal and secondary aspect of disease, fundamentally adjust body's immunity and metabolism, treat
It imitates, drug resistance will not be generated, be conducive to ensure therapeutic effect.And drug residue free, it has no toxic side effect, can also ensure that human body is good for
Health.
Specific embodiment
Embodiment 1
A kind of oral liquid for preventing domestic animal laryngitis, is made by weight of following component：Ammonification Chinese Drug Gualouzi 15, oligomeric different malt
Sugar 0.3, zinc gluconate 0.1, peppermint 10, motherwort 6, semen armeniacae amarae 2, summer be withered 3, humulus grass treatment fluid 30, water 150；
The humulus grass handles liquid and preparation method thereof：It by humulus grass drying, crushes, obtains 100 mesh powder, ethyl alcohol and humulus grass powder are pressed
5:1 mass ratio mixing, when refluxing extraction 3 is small, filtering obtains extracting solution, heating recovery ethyl alcohol, and extracting solution is concentrated to dryness, obtains
Solid content；Obtained solid content and salt, sodium glutamate, water are pressed 1：0.8：0.2：50 weight ratio mixing, is heated to 80
DEG C, 40min is stirred with the rate of 1500r/min, cooled to room temperature is to get humulus grass treatment fluid.
Further, the ammonification Chinese Drug Gualouzi preparation method is：Chinese Drug Gualouzi is smashed it through into 120 mesh sieves, then sprinkling is mixed
Conjunction microbial inoculum, which is placed in vacuum tank, carries out cold fermentation, then adds in ammonification microbial inoculum and carries out ammoniated treatment, and vacuum pressure tank is 8kPa,
Temperature is 40 DEG C, time 35min；The ammonification microbial inoculum is by hay bacillus：Rhizopus oryzae presses 3:1 mass ratio mixes；Described
Cold fermentation, 10 DEG C of fermentation temperature, when fermentation time 3 is small；The mix bacterium agent presses 5 for aspergillus oryzae and saccharomycete:2 mass
Ratio is mixed.
Further, the oral liquor of the prevention domestic animal laryngitis is：
（1）By weight by ammonification Chinese Drug Gualouzi, peppermint, motherwort, semen armeniacae amarae, summer withered uniform mixing, 100 parts by weight are then added
Water, be heated to seething with excitement, keep the temperature 15min, then adjust the temperature to 60 DEG C, when heat preservation 2 is small, it is residual to be then filtered removal solid
Slag obtains filtrate；
（2）Oligoisomaltose and zinc gluconate are dissolved in remaining water, mixed liquor is made, is kept the temperature at 10 DEG C；
（3）First by step（1）In filtrate mixed with humulus grass treatment fluid, be heated to 40 DEG C, with 150r/min rotating speeds stir
Then 20min adjusts the temperature to 10 DEG C, keep the temperature 15min, then add step（2）The mixed liquor of middle preparation, after stirring evenly, warp
Cross ultrasonication 5min, then proceed to heat preservation 1 it is small when, then clear-cutting forestland to room temperature to get.
Further, the step（3）Middle ultrasonic power is 800W, frequency 65kHz.
Embodiment 2
A kind of oral liquid for preventing domestic animal laryngitis, is made by weight of following component：Ammonification Chinese Drug Gualouzi 20, oligomeric different malt
Sugar 0.5, zinc gluconate 0.4, peppermint 12, motherwort 8, semen armeniacae amarae 4, summer be withered 6, humulus grass treatment fluid 50, water 200；
The humulus grass handles liquid and preparation method thereof：It by humulus grass drying, crushes, obtains 100 mesh powder, ethyl alcohol and humulus grass powder are pressed
5:1 mass ratio mixing, when refluxing extraction 3 is small, filtering obtains extracting solution, heating recovery ethyl alcohol, and extracting solution is concentrated to dryness, obtains
Solid content；Obtained solid content and salt, sodium glutamate, water are pressed 1：0.8：0.2：50 weight ratio mixing, is heated to 80
DEG C, 40min is stirred with the rate of 1500r/min, cooled to room temperature is to get humulus grass treatment fluid.
Further, the ammonification Chinese Drug Gualouzi preparation method is：Chinese Drug Gualouzi is smashed it through into 120 mesh sieves, then sprinkling is mixed
Conjunction microbial inoculum, which is placed in vacuum tank, carries out cold fermentation, then adds in ammonification microbial inoculum and carries out ammoniated treatment, and vacuum pressure tank is 8kPa,
Temperature is 40 DEG C, time 35min；The ammonification microbial inoculum is by hay bacillus：Rhizopus oryzae presses 3:1 mass ratio mixes；Described
Cold fermentation, 10 DEG C of fermentation temperature, when fermentation time 3 is small；The mix bacterium agent presses 5 for aspergillus oryzae and saccharomycete:2 mass
Ratio is mixed.
Further, the oral liquor of the prevention domestic animal laryngitis is：
（1）By weight by ammonification Chinese Drug Gualouzi, peppermint, motherwort, semen armeniacae amarae, summer withered uniform mixing, 100 parts by weight are then added
Water, be heated to seething with excitement, keep the temperature 15min, then adjust the temperature to 60 DEG C, when heat preservation 2 is small, it is residual to be then filtered removal solid
Slag obtains filtrate；
（2）Oligoisomaltose and zinc gluconate are dissolved in remaining water, mixed liquor is made, is kept the temperature at 10 DEG C；
（3）First by step（1）In filtrate mixed with humulus grass treatment fluid, be heated to 40 DEG C, with 150r/min rotating speeds stir
Then 20min adjusts the temperature to 10 DEG C, keep the temperature 15min, then add step（2）The mixed liquor of middle preparation, after stirring evenly, warp
Cross ultrasonication 5min, then proceed to heat preservation 1 it is small when, then clear-cutting forestland to room temperature to get.
Further, the step（3）Middle ultrasonic power is 800W, frequency 65kHz.
Embodiment 3
A kind of oral liquid for preventing domestic animal laryngitis, is made by weight of following component：Ammonification Chinese Drug Gualouzi 18, oligomeric different malt
Sugar 0.4, zinc gluconate 0.2, peppermint 11, motherwort 7, semen armeniacae amarae 3, summer be withered 5, humulus grass treatment fluid 40, water 180；
The humulus grass handles liquid and preparation method thereof：It by humulus grass drying, crushes, obtains 100 mesh powder, ethyl alcohol and humulus grass powder are pressed
5:1 mass ratio mixing, when refluxing extraction 3 is small, filtering obtains extracting solution, heating recovery ethyl alcohol, and extracting solution is concentrated to dryness, obtains
Solid content；Obtained solid content and salt, sodium glutamate, water are pressed 1：0.8：0.2：50 weight ratio mixing, is heated to 80
DEG C, 40min is stirred with the rate of 1500r/min, cooled to room temperature is to get humulus grass treatment fluid.
Further, the ammonification Chinese Drug Gualouzi preparation method is：Chinese Drug Gualouzi is smashed it through into 120 mesh sieves, then sprinkling is mixed
Conjunction microbial inoculum, which is placed in vacuum tank, carries out cold fermentation, then adds in ammonification microbial inoculum and carries out ammoniated treatment, and vacuum pressure tank is 8kPa,
Temperature is 40 DEG C, time 35min；The ammonification microbial inoculum is by hay bacillus：Rhizopus oryzae presses 3:1 mass ratio mixes；Described
Cold fermentation, 10 DEG C of fermentation temperature, when fermentation time 3 is small；The mix bacterium agent presses 5 for aspergillus oryzae and saccharomycete:2 mass
Ratio is mixed.
Further, the oral liquor of the prevention domestic animal laryngitis is：
（1）By weight by ammonification Chinese Drug Gualouzi, peppermint, motherwort, semen armeniacae amarae, summer withered uniform mixing, 100 parts by weight are then added
Water, be heated to seething with excitement, keep the temperature 15min, then adjust the temperature to 60 DEG C, when heat preservation 2 is small, it is residual to be then filtered removal solid
Slag obtains filtrate；
（2）Oligoisomaltose and zinc gluconate are dissolved in remaining water, mixed liquor is made, is kept the temperature at 10 DEG C；
（3）First by step（1）In filtrate mixed with humulus grass treatment fluid, be heated to 40 DEG C, with 150r/min rotating speeds stir
Then 20min adjusts the temperature to 10 DEG C, keep the temperature 15min, then add step（2）The mixed liquor of middle preparation, after stirring evenly, warp
Cross ultrasonication 5min, then proceed to heat preservation 1 it is small when, then clear-cutting forestland to room temperature to get.
Further, the step（3）Middle ultrasonic power is 800W, frequency 65kHz.
Comparative example 1：It is differed only in embodiment 1 and ammonification Chinese Drug Gualouzi is replaced with into common untreated 120 mesh Chinese Drug Gualouzi
Powder.
Comparative example 2：It is differed only in embodiment 1 and does not add humulus grass treatment fluid.
Experiment：
Take family chicken 700, about 1 kilogram of weight is divided into 7 groups at random, every group 100, wherein 6 groups added respectively in drinking-water it is real
Apply the oral liquid that example is prepared with comparative example（0.01:100 mass ratioes mix）, feed identical feed, and feed feeding daily
It measures identical, one group of blank control group is set, quotes normal water, after raising ten days, equally attacked with bird flu, observe each composition
Motility rate and cure rate.Continue to raise the family chicken survived ten days, add what embodiment was prepared with comparative example in drinking-water respectively
Oral liquid（0.025:100 mass ratioes mix）, observe the cure rate of each group；It the results are shown in Table 1：
Table 1
As can be seen from Table 1, the oral liquid that prepared by the present invention has bird flu apparent preventive and therapeutic action.
100 oxen morbidity of self-employed pig raiser's raising is tested, clinical symptoms：Cough is violent, and sound is very brief, sound
It is hoarse, it feels depressed.It is diagnosed as domestic animal laryngitis.By 0.025:100 ratio uniform is scattered in drinking-water, and pig is allowed freely to drink, and 3
After it, the state of an illness is controlled, and spiritual dietary amount recovers.
Claims (4)
1. a kind of oral liquid for preventing domestic animal laryngitis, which is characterized in that be made by weight of following component：Ammonification Chinese Drug Gualouzi
15-20, oligoisomaltose 0.3-0.5, zinc gluconate 0.1-0.4, peppermint 10-12, motherwort 6-8, semen armeniacae amarae 2-4, summer
Withered 3-6, humulus grass treatment fluid 30-50, water 150-200；
The humulus grass handles liquid and preparation method thereof：It by humulus grass drying, crushes, obtains 100 mesh powder, ethyl alcohol and humulus grass powder are pressed
5:1 mass ratio mixing, when refluxing extraction 3 is small, filtering obtains extracting solution, heating recovery ethyl alcohol, and extracting solution is concentrated to dryness, obtains
Solid content；Obtained solid content and salt, sodium glutamate, water are pressed 1：0.8：0.2：50 weight ratio mixing, is heated to 80
DEG C, 40min is stirred with the rate of 1500r/min, cooled to room temperature is to get humulus grass treatment fluid.
2. a kind of oral liquid for preventing domestic animal laryngitis as described in claim 1, which is characterized in that prepared by the ammonification Chinese Drug Gualouzi
Method is：Chinese Drug Gualouzi is smashed it through into 120 mesh sieves, then sprinkling mix bacterium agent, which is placed in vacuum tank, carries out cold fermentation, then
It adds in ammonification microbial inoculum and carries out ammoniated treatment, vacuum pressure tank is 8kPa, and temperature is 40 DEG C, time 35min；The ammonification microbial inoculum by
Hay bacillus：Rhizopus oryzae presses 3:1 mass ratio mixes；The cold fermentation, 10 DEG C of fermentation temperature, when fermentation time 3 is small；
The mix bacterium agent presses 5 for aspergillus oryzae and saccharomycete:2 mass ratios are mixed.
3. a kind of oral liquid for preventing domestic animal laryngitis as described in claim 1, which is characterized in that the prevention domestic animal laryngitis
Oral liquor is：
（1）By weight by ammonification Chinese Drug Gualouzi, peppermint, motherwort, semen armeniacae amarae, summer withered uniform mixing, 100 parts by weight are then added
Water, be heated to seething with excitement, keep the temperature 15min, then adjust the temperature to 60 DEG C, when heat preservation 2 is small, it is residual to be then filtered removal solid
Slag obtains filtrate；
（2）Oligoisomaltose and zinc gluconate are dissolved in remaining water, mixed liquor is made, is kept the temperature at 10 DEG C；
（3）First by step（1）In filtrate mixed with humulus grass treatment fluid, be heated to 40 DEG C, with 150r/min rotating speeds stir
Then 20min adjusts the temperature to 10 DEG C, keep the temperature 15min, then add step（2）The mixed liquor of middle preparation, after stirring evenly, warp
Cross ultrasonication 5min, then proceed to heat preservation 1 it is small when, then clear-cutting forestland to room temperature to get.
A kind of 4. oral liquid for preventing domestic animal laryngitis as claimed in claim 3, which is characterized in that the step（3）Middle ultrasound
Wave power is 800W, frequency 65kHz.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108949026A (en) * | 2018-06-19 | 2018-12-07 | 明光市天淼新能源科技有限公司 | A kind of Wear-resisting compound board |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108949026A (en) * | 2018-06-19 | 2018-12-07 | 明光市天淼新能源科技有限公司 | A kind of Wear-resisting compound board |
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