CN108066821A - 一种用于腹壁缺损修复的复合生物补片 - Google Patents
一种用于腹壁缺损修复的复合生物补片 Download PDFInfo
- Publication number
- CN108066821A CN108066821A CN201611038269.4A CN201611038269A CN108066821A CN 108066821 A CN108066821 A CN 108066821A CN 201611038269 A CN201611038269 A CN 201611038269A CN 108066821 A CN108066821 A CN 108066821A
- Authority
- CN
- China
- Prior art keywords
- sticking patch
- abdominal
- compound bio
- bletilla striata
- wall defect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 27
- 208000021970 Abdominal wall defect Diseases 0.000 title claims abstract description 22
- 241001313857 Bletilla striata Species 0.000 claims abstract description 35
- 239000000835 fiber Substances 0.000 claims abstract description 23
- 238000010041 electrostatic spinning Methods 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims description 16
- 210000003516 pericardium Anatomy 0.000 claims description 5
- 239000011159 matrix material Substances 0.000 claims description 4
- 210000001691 amnion Anatomy 0.000 claims description 3
- 210000004347 intestinal mucosa Anatomy 0.000 claims description 3
- 241000283690 Bos taurus Species 0.000 claims description 2
- 241000446313 Lamella Species 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 abstract description 3
- 230000002924 anti-infective effect Effects 0.000 abstract description 2
- 239000012620 biological material Substances 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 abstract description 2
- 230000037314 wound repair Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 10
- 239000003814 drug Substances 0.000 description 4
- 230000008439 repair process Effects 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 206010019909 Hernia Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001523 electrospinning Methods 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000002407 reforming Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 241001313855 Bletilla Species 0.000 description 1
- 241000283725 Bos Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 208000032420 Latent Infection Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000037771 disease arising from reactivation of latent virus Diseases 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000008263 repair mechanism Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000000250 revascularization Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3637—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the origin of the biological material other than human or animal, e.g. plant extracts, algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Materials For Medical Uses (AREA)
Abstract
本发明属于医用生物材料技术领域，公开了一种用于腹壁缺损修复的复合生物补片，该种复合生物补片包含生物补片层以及覆膜于该生物补片层一侧表面的白芨纤维网层；且该白芨纤维网层为静电纺丝纳米级白芨纤维网。本发明通过将纳米白芨纤维网层与传统生物补片覆膜结合，使得到的复合生物补片的抗感染能力、创面修复能力得到有效提高；同时，该复合生物补片植入机体后的力学强度变化始终高于所需的力学强度，可加速组织重建，有助于解决生物补片现存技术瓶颈，有效改善腹壁缺损修复的治疗效果。
Description
技术领域
本发明涉及一种医用生物材料，尤其是一种医用生物补片。
背景技术
生物补片的研发和应用是当前疝和腹壁外科研究的一个重要方向。生物补片是指取自同种、异种的组织，经脱细胞处理去除组织中含有的各种细胞而完整保留细胞外基质的三维框架结构并能用于修复人体软组织的材料。其根据组织来源可分为同种异体材料如真皮脱细胞基质、羊膜、硬脑膜等，异种异体材料如猪小肠黏膜下层、牛马的心包、牛腹膜等。
生物补片植入后，随着宿主组织的长入.生物补片逐步降解，最终生物补片完全被宿主组织代替。因此，生物补片修复机制是“内源性组织再生”，其诱导干细胞进入生物补片，分泌细胞外基质替代降解的植入物。生物补片具有一定的耐受感染能力，这得益于其能实现早期局部快速再血管化、吞噬细胞早期进入，使细菌生物膜难以形成，故生物补片可用于伴有污染或潜在感染的创面。
但目前的生物补片尚存在一些亟待解决的难题。生物补片植入机体后补片本身降解的同时又有组织重建，如果这两者的合成力学曲线在植入体内的力学强度变化始终高于植入体的力学强度，那么该补片修补能达到预期目的；反之，修补就会失败。究其原因，无外乎以下两个原因：1、生物补片降解过快，而组织重建相对缓慢，导致这两者的合成力学曲线在某个阶段低于腹壁力学强度。2、生物补片降解虽慢，而组织重建相对不足，最终仍导致修补失败。
发明内容
本发明的目的在于提供一种适用于疝和腹壁外科修复的复合生物补片，有效改善临床腹壁缺损修复的治疗效果。
为解决上述技术问题，本发明提供了一种用于腹壁缺损修复的复合生物补片，该复合生物补片包含生物补片层以及覆膜于生物补片层一侧表面的白芨纤维网层。我国传统中药白芨在临床上对促进伤口愈合疗效独特，能加速组织重建。近年来，通过现代医学研究进一步确切证实，白芨的有效成分具有提高创面组织中巨噬细胞、促进血管内皮细胞粘附生长的功能，可显著提高细胞的增殖能力，同时还有抑菌止血的功能。本发明通过将白芨纤维网层与传统生物补片覆膜结合，使得到的复合生物补片在植入体内后的抗感染能力、创面修复能力得到有效提高。此外，本发明所提供的复合生物补片植入机体后的力学强度变化始终高于所需的力学强度，可加速组织重建，有助于解决生物补片现存瓶颈，进一步改善腹壁缺损修复的治疗效果。
优选地，本发明所提供的用于腹壁缺损修复的复合生物补片中，覆膜于传统生物补片表面的白芨纤维网层为纳米级白芨纤维网；进一步地，纳米级白芨纤维网的纤维直径为100～500纳米，该纳米级白芨纤维网的厚度为0.2～1毫米。纳米级的白芨纤维网层由于材料的微小直径使其具有较大的比表面积，在药物缓释应用中有极大地优势，有利于更好地发挥白芨纤维层对传统生物补片在修复效果上的改善作用。
优选地，本发明所提供的用于腹壁缺损修复的复合生物补片中，纳米级白芨纤维网为静电纺丝纳米级白芨纤维网。静电纺丝，也称电纺丝，是一种利用聚合物溶液或熔体在强电场作用下形成喷射流进行纺丝加工的工艺。制得的纤维直径可以达到纳米量级。还可在其中引入无机粒子、活性成分、药物等来改善材料的性能，通过结构、成分的控制，达到促进引导组织再生功能的作用，电纺技术制作的功能化纳米电纺丝材料，在组织工程、创伤敷料、酶的固定化和药物(基因)载体等生物医学方面得到了广泛的应用。本发明所提供的复合生物补片，采用以静电纺丝技术制备的纳米级白芨纤维网与传统生物补片覆膜结合，进一步优化了复合生物补片的医用性能。
进一步地，本发明所提供的用于腹壁缺损修复的复合生物补片中，生物补片层为市场购买的常规生物补片。具体可以是同种异体材料型补片或异种异体材料型补片。其中，同种异体材料型补片可以为真皮脱细胞基质来源补片、羊膜来源补片或硬脑膜来源补片等；异种异体材料型补片为猪小肠黏膜下层来源补片、牛心包来源补片、马心包来源补片或牛腹膜来源补片等。例如可以是购买自库克(Cook)、清源伟业、冠昊等公司的生物补片。
附图说明
图1是本发明第一实施方式的用于腹壁缺损修复的复合生物补片的结构示意图。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面将结合附图对本发明的各实施方式进行详细的阐述。然而，本领域的普通技术人员可以理解，在本发明各实施方式中，为了使读者更好地理解本申请而提出了许多技术细节。但是，即使没有这些技术细节和基于以下各实施方式的种种变化和修改，也可以实现本申请各权利要求所要求保护的技术方案。
本发明的第一实施方式所涉及的用于腹壁缺损修复的复合生物补片包含生物补片层1以及覆膜于生物补片层1一侧表面的白芨纤维网层2。
上述的白芨纤维网层2的厚度为0.2毫米，纳米级白芨纤维的纤维直径为100纳米，且该纳米级白芨纤维网采用静电纺丝制备而得。上述的生物补片层1购自库克(Cook)公司，商品名为百得塞，为猪小肠粘膜下层脱细胞基质生物补片。
本发明的第二实施方式所涉及的用于腹壁缺损修复的复合生物补片也包含生物补片层以及覆膜于生物补片层一侧表面的纳米级白芨纤维网层。
本实施方式中的纳米级白芨纤维网层的厚度为1毫米，纳米级白芨纤维的纤维直径为300纳米，且该纳米级白芨纤维网采用静电纺丝制备而得。本实施方式中的生物补片层购自清源伟业公司。
本发明的第三实施方式所涉及的用于腹壁缺损修复的复合生物补片也包含生物补片层以及覆膜于生物补片层一侧表面的纳米级白芨纤维网层。
本实施方式中的纳米级白芨纤维网层的厚度为0.6毫米，纳米级白芨纤维的纤维直径为500纳米，且该纳米级白芨纤维网采用静电纺丝制备而得。本实施方式中的生物补片层购自冠昊公司。
本领域的普通技术人员可以理解，上述各实施方式是实现本发明的具体实施例，而在实际应用中，可以在形式上和细节上对其作各种改变，而不偏离本发明的精神和范围。
Claims (8)
1.一种用于腹壁缺损修复的复合生物补片，其特征在于，包含生物补片层(1)以及覆膜于所述生物补片层(1)一侧表面的白芨纤维网层(2)。
2.根据权利要求1所述的用于腹壁缺损修复的复合生物补片，其特征在于，所述白芨纤维网层(2)为纳米级白芨纤维网。
3.根据权利要求2所述的用于腹壁缺损修复的复合生物补片，其特征在于，所述纳米级白芨纤维网的纤维直径为100～500纳米。
4.根据权利要求2所述的用于腹壁缺损修复的复合生物补片，其特征在于，所述纳米级白芨纤维网的厚度为0.2～1毫米。
5.根据权利要求2所述的用于腹壁缺损修复的复合生物补片，其特征在于，所述纳米级白芨纤维网为静电纺丝纳米级白芨纤维网。
6.根据权利要求1所述的用于腹壁缺损修复的复合生物补片，其特征在于，所述生物补片层(1)为同种异体材料型补片或异种异体材料型补片。
7.根据权利要求6所述的用于腹壁缺损修复的复合生物补片，其特征在于，所述同种异体材料型补片为真皮脱细胞基质来源补片、羊膜来源补片或硬脑膜来源补片。
8.根据权利要求6所述的用于腹壁缺损修复的复合生物补片，其特征在于，所述异种异体材料型补片为猪小肠黏膜下层来源补片、牛心包来源补片、马心包来源补片或牛腹膜来源补片。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611038269.4A CN108066821A (zh) | 2016-11-10 | 2016-11-10 | 一种用于腹壁缺损修复的复合生物补片 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611038269.4A CN108066821A (zh) | 2016-11-10 | 2016-11-10 | 一种用于腹壁缺损修复的复合生物补片 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108066821A true CN108066821A (zh) | 2018-05-25 |
Family
ID=62161317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611038269.4A Pending CN108066821A (zh) | 2016-11-10 | 2016-11-10 | 一种用于腹壁缺损修复的复合生物补片 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108066821A (zh) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904866A (zh) * | 2018-07-27 | 2018-11-30 | 武汉纺织大学 | 一种双层白芨敷料 |
| CN109224132A (zh) * | 2018-09-17 | 2019-01-18 | 上海大学 | 多层复合腹壁修复补片支架及其制备方法 |
| CN109276759A (zh) * | 2018-11-27 | 2019-01-29 | 北京航空航天大学 | 一种仿生抗菌腹壁修复材料 |
| CN111407924A (zh) * | 2020-04-17 | 2020-07-14 | 南京鼓楼医院 | 一种具有各向异性表面的复合补片及其制备方法和应用 |
| CN111450320A (zh) * | 2020-03-24 | 2020-07-28 | 江西省科星生物工程有限公司 | 生物组织腹壁缺损修复材料 |
| CN114984323A (zh) * | 2022-06-15 | 2022-09-02 | 上海交通大学医学院附属第九人民医院 | 一种腹壁缺损修复材料及制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6319264B1 (en) * | 1998-04-03 | 2001-11-20 | Bionx Implants Oy | Hernia mesh |
| CN102284012A (zh) * | 2011-08-09 | 2011-12-21 | 临沂大学 | 一种含有姜黄素与白芨胶的凝胶贴剂及其制备方法 |
| CN102698319A (zh) * | 2012-03-02 | 2012-10-03 | 首都医科大学附属北京朝阳医院 | 一种抗肿瘤生物补片 |
| CN102698318A (zh) * | 2012-03-02 | 2012-10-03 | 首都医科大学附属北京朝阳医院 | 一种生物材料复合补片 |
-
2016
- 2016-11-10 CN CN201611038269.4A patent/CN108066821A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6319264B1 (en) * | 1998-04-03 | 2001-11-20 | Bionx Implants Oy | Hernia mesh |
| CN102284012A (zh) * | 2011-08-09 | 2011-12-21 | 临沂大学 | 一种含有姜黄素与白芨胶的凝胶贴剂及其制备方法 |
| CN102698319A (zh) * | 2012-03-02 | 2012-10-03 | 首都医科大学附属北京朝阳医院 | 一种抗肿瘤生物补片 |
| CN102698318A (zh) * | 2012-03-02 | 2012-10-03 | 首都医科大学附属北京朝阳医院 | 一种生物材料复合补片 |
Non-Patent Citations (2)
| Title |
|---|
| 崔志香: "《生物可降解组织工程支架成型及其结构性能》", 31 January 2015, 国防工业出版社 * |
| 王雷等: "白及多糖胶抑菌效果与在嵌顿疝手术中作用的探讨", 《内蒙古中医药》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904866A (zh) * | 2018-07-27 | 2018-11-30 | 武汉纺织大学 | 一种双层白芨敷料 |
| CN108904866B (zh) * | 2018-07-27 | 2021-05-28 | 武汉纺织大学 | 一种双层白芨敷料 |
| CN109224132A (zh) * | 2018-09-17 | 2019-01-18 | 上海大学 | 多层复合腹壁修复补片支架及其制备方法 |
| CN109276759A (zh) * | 2018-11-27 | 2019-01-29 | 北京航空航天大学 | 一种仿生抗菌腹壁修复材料 |
| CN111450320A (zh) * | 2020-03-24 | 2020-07-28 | 江西省科星生物工程有限公司 | 生物组织腹壁缺损修复材料 |
| CN111407924A (zh) * | 2020-04-17 | 2020-07-14 | 南京鼓楼医院 | 一种具有各向异性表面的复合补片及其制备方法和应用 |
| CN114984323A (zh) * | 2022-06-15 | 2022-09-02 | 上海交通大学医学院附属第九人民医院 | 一种腹壁缺损修复材料及制备方法 |
| CN114984323B (zh) * | 2022-06-15 | 2023-09-12 | 上海交通大学医学院附属第九人民医院 | 一种腹壁缺损修复材料及制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108066821A (zh) | 一种用于腹壁缺损修复的复合生物补片 | |
| Li et al. | Advanced electrospun hydrogel fibers for wound healing | |
| Han et al. | Tissue engineering and regenerative medicine: achievements, future, and sustainability in Asia | |
| Zare et al. | Graphene oxide: opportunities and challenges in biomedicine | |
| Dias et al. | Advances in electrospun skin substitutes | |
| Wu et al. | Fabrication of aligned nanofiber polymer yarn networks for anisotropic soft tissue scaffolds | |
| Bucciarelli et al. | Use of Bombyx mori silk fibroin in tissue engineering: From cocoons to medical devices, challenges, and future perspectives | |
| Brennan et al. | Antibacterial activity within degradation products of biological scaffolds composed of extracellular matrix | |
| Sridhar et al. | Electrospun inorganic and polymer composite nanofibers for biomedical applications | |
| CN103764071B (zh) | 鼓室修补器械 | |
| Hong et al. | Three-dimensional scaffold of electrosprayed fibers with large pore size for tissue regeneration | |
| CN108601644A (zh) | 用于组织修复的纤维-水凝胶复合材料外科网片 | |
| Cassidy | Nanotechnology in the regeneration of complex tissues | |
| CN106132447A (zh) | 生物医学装置 | |
| CN107106695A (zh) | 用于增强骨和软组织的愈合和再生的组合物和方法 | |
| Dill et al. | Biological dermal templates with native collagen scaffolds provide guiding ridges for invading cells and may promote structured dermal wound healing | |
| Du et al. | Nanomaterials for wound healing: scope and advances | |
| CN104815355B (zh) | 表面具有纳米纤维多孔结构的羟基磷灰石/聚酰胺复合生物材料及其制备方法 | |
| Safi et al. | Preparing polycaprolactone scaffolds using electrospinning technique for construction of artificial periodontal ligament tissue | |
| Wang et al. | Engineered Sandwich‐Structured Composite Wound Dressings with Unidirectional Drainage and Anti‐Adhesion Supporting Accelerated Wound Healing | |
| Sun et al. | Clinical application of a 3D-printed scaffold in chronic wound treatment: a case series | |
| Alarçin et al. | Recreating composition, structure, functionalities of tissues at nanoscale for regenerative medicine | |
| Deepika et al. | Applications of nanoscaffolds in tissue engineering | |
| Leonhäuser et al. | Two differentially structured collagen scaffolds for potential urinary bladder augmentation: proof of concept study in a Göttingen minipig model | |
| KR20200010344A (ko) | 실 및 그 제조 방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Huang Jianping Inventor after: Xie Xiaofeng Inventor before: Huang Jianping |
|
| CB03 | Change of inventor or designer information | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180525 |
|
| RJ01 | Rejection of invention patent application after publication |