CN108066563A - A kind of Reishi sporule powder particles and preparation method thereof - Google Patents

A kind of Reishi sporule powder particles and preparation method thereof Download PDF

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Publication number
CN108066563A
CN108066563A CN201711468048.5A CN201711468048A CN108066563A CN 108066563 A CN108066563 A CN 108066563A CN 201711468048 A CN201711468048 A CN 201711468048A CN 108066563 A CN108066563 A CN 108066563A
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China
Prior art keywords
parts
reishi sporule
powder particles
powder
lucidum spore
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Pending
Application number
CN201711468048.5A
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Chinese (zh)
Inventor
曹剑
施鼎铭
施深海
陈强
陈方潭
厉云彪
陆娟
刘兴约
施海燕
卢晓智
陈君丽
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Zhejiang Dacheng Pharmaceutical Co Ltd
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Zhejiang Dacheng Pharmaceutical Co Ltd
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Priority to CN201711468048.5A priority Critical patent/CN108066563A/en
Publication of CN108066563A publication Critical patent/CN108066563A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487Psoralea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of Reishi sporule powder particles and preparation method thereof, which is made of following weight composition:7 11 parts of 33 76 parts of Reishi sporule, 12 31 parts of Radix Salviae Miltiorrhizae, 47 parts of Cortex Eucommiae, 25 parts of psoralea corylifolia, 19 parts of Chinese yam, 6 12 parts of matrimony vine and pueraria lobata.Comprehensive broken wall treatment is carried out to lucidum spore powder during lucidum spore powder particle preparation of the present invention, drug effect absorptivity can be improved to the greatest extent;The pharmacological property of plurality of Chinese is mixed among lucidum spore powder simultaneously, substantially increases the drug effect of product.

Description

A kind of Reishi sporule powder particles and preparation method thereof
Technical field
The present invention relates to a kind of Reishi sporule powder particles and preparation method thereof.
Background technology
Reishi sporule is the seed that ganoderma lucidum generates release in development later stage, is the elite of ganoderma lucidum.Lucidum spore powder is in nature Under the conditions of very difficult collection
The conidia powder human body of outer wall, not broken wall that the extremely difficult chitin digested by human body hydrochloric acid in gastric juice of one layer of ganoderma lucidum spore oil is formed It can not digest and assimilate.From earliest ganoderma lucidum cap cut into slices it is to boil water drink directly with conidia powder brew, can all cause a large amount of drug effects Waste, therefore produce a kind of ganoderma spove powder health product can bigger raising drug effect utilization rate.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of easy to make and convenient to eat, can efficiently utilize spirit comprehensively The Reishi sporule powder particles of Ganoderma lucidum spore powder drug effect.
To solve the above problems, the present invention is achieved through the following technical solutions:A kind of Reishi sporule powder particles, should Reishi sporule powder particles are made of following weight composition:33-76 parts of Reishi sporule, 12-31 parts of Radix Salviae Miltiorrhizae, Cortex Eucommiae 4-7 7-11 parts of part, 2-5 parts of psoralea corylifolia, 1-9 parts of Chinese yam, 6-12 parts of matrimony vine and pueraria lobata.
Another technical problem to be solved by this invention is to provide a kind of preparation method of Reishi sporule powder particles,
The present invention is achieved through the following technical solutions:The preparation process of the Reishi sporule powder particles is as follows:
1) 33-76 parts of Reishi sporule is extracted by weight ratio to clean, dry, be positioned in crusher and shear broken wall, grind After worn-off wall lucidum spore powder is filtered by 1000 mesh screens;
2) 12-31 parts of Radix Salviae Miltiorrhizae, 4-7 parts of Cortex Eucommiae, 2-5 parts of psoralea corylifolia, 1-9 parts of Chinese yam, matrimony vine 6- are extracted by weight ratio 12 parts and 7-11 parts of cleanings of pueraria lobata, dry rear mixed grinding into powder;
3) extraction step 1 and the mixed-powder of step 2 are stirred, and uniformly carry out screening and filtering after mixing;
4) sieve of extraction step 3 takes object, and particle is made using conventional method.
The advantageous effect of Reishi sporule powder particles of the present invention is:To lucidum spore powder during the lucidum spore powder particle preparation Comprehensive broken wall treatment is carried out, drug effect absorptivity can be improved to the greatest extent;The pharmacological property of plurality of Chinese is mixed into ganoderma lucidum spore simultaneously Among sub- powder, the drug effect of product is substantially increased.
Specific embodiment
Following embodiment is not limited to the scope of the present invention for illustrating the present invention.
Embodiment 1
A kind of Reishi sporule powder particles of the present invention, which is by following weight composition group Into:7 parts of 33 parts of Reishi sporule, 12 parts of Radix Salviae Miltiorrhizae, 4 parts of Cortex Eucommiae, 2 parts of psoralea corylifolia, 1 part of Chinese yam, 6 parts of matrimony vine and pueraria lobata.
The preparation process of the Reishi sporule powder particles is as follows:
1) 33 parts of Reishi sporule is extracted by weight ratio to clean, dry, be positioned in crusher and shear broken wall, grinding is broken After wall lucidum spore powder is filtered by 1000 mesh screens;
2) 7 parts of 12 parts of Radix Salviae Miltiorrhizae, 4 parts of Cortex Eucommiae, 2 parts of psoralea corylifolia, 1 part of Chinese yam, 6 parts of matrimony vine and pueraria lobata are extracted by weight ratio Cleaning, dries rear mixed grinding into powder;
3) extraction step 1 and the mixed-powder of step 2 are stirred, and uniformly carry out screening and filtering after mixing;
4) sieve of extraction step 3 takes object, and particle is made using conventional method.
Embodiment 2
Its difference from Example 1 is that the Reishi sporule powder particles are made of following weight composition:Spirit 11 parts of 76 parts of Ganoderma lucidum spore, 31 parts of Radix Salviae Miltiorrhizae, 7 parts of Cortex Eucommiae, 5 parts of psoralea corylifolia, 9 parts of Chinese yam, 12 parts of matrimony vine and pueraria lobata.
Embodiment 3
Its difference from Example 1 is that the Reishi sporule powder particles are made of following weight composition:Spirit 9 parts of 55 parts of Ganoderma lucidum spore, 21 parts of Radix Salviae Miltiorrhizae, 5 parts of Cortex Eucommiae, 3 parts of psoralea corylifolia, 5 parts of Chinese yam, 9 parts of matrimony vine and pueraria lobata.
Embodiment 4
Its difference from Example 1 is that the Reishi sporule powder particles are made of following weight composition:Spirit 8 parts of 37 parts of Ganoderma lucidum spore, 14 parts of Radix Salviae Miltiorrhizae, 4.6 parts of Cortex Eucommiae, 2.5 parts of psoralea corylifolia, 2 parts of Chinese yam, 7 parts of matrimony vine and pueraria lobata.
Embodiment 5
Its difference from Example 1 is that the Reishi sporule powder particles are made of following weight composition:Spirit 10 parts of 71 parts of Ganoderma lucidum spore, 28 parts of Radix Salviae Miltiorrhizae, 6 parts of Cortex Eucommiae, 4 parts of psoralea corylifolia, 8 parts of Chinese yam, 11 parts of matrimony vine and pueraria lobata.
Embodiment 6
Its difference from Example 1 is that the Reishi sporule powder particles are made of following weight composition:Spirit 7.5 parts of 43 parts of Ganoderma lucidum spore, 25 parts of Radix Salviae Miltiorrhizae, 5 parts of Cortex Eucommiae, 3.3 parts of psoralea corylifolia, 4.7 parts of Chinese yam, 8.8 parts of matrimony vine and pueraria lobata.
Embodiment 7
Its difference from Example 1 is that the Reishi sporule powder particles are made of following weight composition:Spirit 11 parts of 62 parts of Ganoderma lucidum spore, 16 parts of Radix Salviae Miltiorrhizae, 4.8 parts of Cortex Eucommiae, 4.2 parts of psoralea corylifolia, 6 parts of Chinese yam, 6 parts of matrimony vine and pueraria lobata.
Embodiment 8
Its difference from Example 1 is that the Reishi sporule powder particles are made of following weight composition:Iron 8 parts of 55 parts of Reishi sporule, 20 parts of Radix Salviae Miltiorrhizae, 5.5 parts of Cortex Eucommiae, 5 parts of psoralea corylifolia, 5 parts of Chinese yam, 10 parts of matrimony vine and pueraria lobata.
The present invention is not limited to above-mentioned preferred forms, anyone the present invention enlightenment under draw other it is any with Product as the present invention is same or similar, is within the scope of the present invention.

Claims (2)

1. a kind of Reishi sporule powder particles, it is characterised in that:The Reishi sporule powder particles are by following weight composition group Into:33-76 parts of Reishi sporule, 12-31 parts of Radix Salviae Miltiorrhizae, 4-7 parts of Cortex Eucommiae, 2-5 parts of psoralea corylifolia, 1-9 parts of Chinese yam, 6-12 parts of matrimony vine and Pueraria lobota 7-11 parts of root.
2. a kind of preparation method for preparing Reishi sporule powder particles described in claim 1, it is characterised in that:This method include with Lower step:
1) 33-76 parts of Reishi sporule is extracted by weight ratio to clean, dry, be positioned in crusher and shear broken wall, grinding is broken After wall lucidum spore powder is filtered by 1000 mesh screens;
2) 12-31 parts of Radix Salviae Miltiorrhizae, 4-7 parts of Cortex Eucommiae, 2-5 parts of psoralea corylifolia, 1-9 parts of Chinese yam, 6-12 parts of matrimony vine are extracted by weight ratio With 7-11 parts of cleanings of pueraria lobata, rear mixed grinding is dried into powder;
3) extraction step 1 and the mixed-powder of step 2 are stirred, and uniformly carry out screening and filtering after mixing;
4) sieve of extraction step 3 takes object, and particle is made using conventional method.
CN201711468048.5A 2017-12-29 2017-12-29 A kind of Reishi sporule powder particles and preparation method thereof Pending CN108066563A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109329897A (en) * 2018-10-19 2019-02-15 中南大学 A kind of adjuvant treatment food compositions and preparation method thereof for cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101856430A (en) * 2009-04-08 2010-10-13 周艳 Green tonic lucid ganoderma (three immortals) cream for preventing sub-health and preparation method thereof
CN103190605A (en) * 2013-04-24 2013-07-10 东北大学 Method for preparing ganodorma wall-broken spore powder
CN104524188A (en) * 2014-12-25 2015-04-22 平阴县中医医院 Medicament for treating vascular dementia and preparation method of medicament
CN106265774A (en) * 2016-10-19 2017-01-04 南京希元生物医药科技有限公司 A kind of preparation technology of Ganoderma spore powder particles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101856430A (en) * 2009-04-08 2010-10-13 周艳 Green tonic lucid ganoderma (three immortals) cream for preventing sub-health and preparation method thereof
CN103190605A (en) * 2013-04-24 2013-07-10 东北大学 Method for preparing ganodorma wall-broken spore powder
CN104524188A (en) * 2014-12-25 2015-04-22 平阴县中医医院 Medicament for treating vascular dementia and preparation method of medicament
CN106265774A (en) * 2016-10-19 2017-01-04 南京希元生物医药科技有限公司 A kind of preparation technology of Ganoderma spore powder particles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109329897A (en) * 2018-10-19 2019-02-15 中南大学 A kind of adjuvant treatment food compositions and preparation method thereof for cancer

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Application publication date: 20180525